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O15444

- CCL25_HUMAN

UniProt

O15444 - CCL25_HUMAN

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Protein

C-C motif chemokine 25

Gene

CCL25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

GO - Molecular functioni

  1. CCR10 chemokine receptor binding Source: BHF-UCL
  2. chemokine activity Source: UniProtKB
  3. chemokine receptor binding Source: UniProtKB
  4. hormone activity Source: ProtInc

GO - Biological processi

  1. cell chemotaxis Source: UniProtKB
  2. cell surface receptor signaling pathway Source: ProtInc
  3. chemotaxis Source: ProtInc
  4. G-protein coupled receptor signaling pathway Source: UniProtKB
  5. immune response Source: ProtInc
  6. inflammatory response Source: UniProtKB-KW
  7. leukocyte migration Source: Ensembl
  8. negative regulation of leukocyte tethering or rolling Source: UniProtKB
  9. positive regulation of cell-matrix adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 25
Alternative name(s):
Chemokine TECK
Small-inducible cytokine A25
Thymus-expressed chemokine
Gene namesi
Name:CCL25
Synonyms:SCYA25, TECK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:10624. CCL25.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35556.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 150127C-C motif chemokine 25PRO_0000005235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 58By similarity
Disulfide bondi31 ↔ 75By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO15444.
PRIDEiO15444.

PTM databases

PhosphoSiteiO15444.

Expressioni

Tissue specificityi

Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.

Gene expression databases

BgeeiO15444.
CleanExiHS_CCL25.
ExpressionAtlasiO15444. baseline.
GenevestigatoriO15444.

Organism-specific databases

HPAiHPA055883.

Interactioni

Protein-protein interaction databases

BioGridi112273. 1 interaction.
DIPiDIP-5883N.
IntActiO15444. 1 interaction.
MINTiMINT-106224.
STRINGi9606.ENSP00000375086.

Structurei

3D structure databases

ProteinModelPortaliO15444.
SMRiO15444. Positions 28-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39655.
GeneTreeiENSGT00510000049257.
HOGENOMiHOG000293281.
HOVERGENiHBG050832.
InParanoidiO15444.
KOiK13072.
OMAiAWAPAVH.
OrthoDBiEOG76MKB6.
PhylomeDBiO15444.
TreeFamiTF353160.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O15444-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLWLLACLV AGFLGAWAPA VHTQGVFEDC CLAYHYPIGW AVLRRAWTYR
60 70 80 90 100
IQEVSGSCNL PAAIFYLPKR HRKVCGNPKS REVQRAMKLL DARNKVFAKL
110 120 130 140 150
HHNTQTFQAG PHAVKKLSSG NSKLSSSKFS NPISSSKRNV SLLISANSGL
Length:150
Mass (Da):16,609
Last modified:July 22, 2008 - v2
Checksum:i91D0810F137FBC7B
GO
Isoform 2 (identifier: O15444-2) [UniParc]FASTAAdd to Basket

Also known as: TECKvar

The sequence of this isoform differs from the canonical sequence as follows:
     65-150: FYLPKRHRKV...SLLISANSGL → RPSCCKEVEFWKLQVIIIQV

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:84
Mass (Da):9,496
Checksum:i11307E0137B394D4
GO
Isoform 3 (identifier: O15444-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: Missing.

Show »
Length:149
Mass (Da):16,538
Checksum:iAC5468E6EF71986E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231T → A.
Corresponds to variant rs960173 [ dbSNP | Ensembl ].
VAR_044519
Natural varianti101 – 1011H → R.
Corresponds to variant rs2032887 [ dbSNP | Ensembl ].
VAR_044520
Natural varianti104 – 1041T → M.1 Publication
Corresponds to variant rs1129763 [ dbSNP | Ensembl ].
VAR_044521

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei65 – 15086FYLPK…ANSGL → RPSCCKEVEFWKLQVIIIQV in isoform 2. 1 PublicationVSP_001064Add
BLAST
Alternative sequencei109 – 1091Missing in isoform 3. 2 PublicationsVSP_043199

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86358 mRNA. Translation: AAB69981.1.
AB046579 mRNA. Translation: BAB62257.1.
AK292662 mRNA. Translation: BAF85351.1.
AC008946 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW68952.1.
BC130561 mRNA. Translation: AAI30562.1.
BC144463 mRNA. Translation: AAI44464.1.
CCDSiCCDS12194.1. [O15444-1]
CCDS56080.1. [O15444-3]
RefSeqiNP_001188288.1. NM_001201359.1. [O15444-3]
NP_005615.2. NM_005624.3. [O15444-1]
UniGeneiHs.310511.

Genome annotation databases

EnsembliENST00000253451; ENSP00000253451; ENSG00000131142. [O15444-3]
ENST00000390669; ENSP00000375086; ENSG00000131142. [O15444-1]
GeneIDi6370.
KEGGihsa:6370.
UCSCiuc002mjc.4. human. [O15444-3]
uc002mjd.3. human. [O15444-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL25 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86358 mRNA. Translation: AAB69981.1 .
AB046579 mRNA. Translation: BAB62257.1 .
AK292662 mRNA. Translation: BAF85351.1 .
AC008946 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW68952.1 .
BC130561 mRNA. Translation: AAI30562.1 .
BC144463 mRNA. Translation: AAI44464.1 .
CCDSi CCDS12194.1. [O15444-1 ]
CCDS56080.1. [O15444-3 ]
RefSeqi NP_001188288.1. NM_001201359.1. [O15444-3 ]
NP_005615.2. NM_005624.3. [O15444-1 ]
UniGenei Hs.310511.

3D structure databases

ProteinModelPortali O15444.
SMRi O15444. Positions 28-91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112273. 1 interaction.
DIPi DIP-5883N.
IntActi O15444. 1 interaction.
MINTi MINT-106224.
STRINGi 9606.ENSP00000375086.

PTM databases

PhosphoSitei O15444.

Proteomic databases

PaxDbi O15444.
PRIDEi O15444.

Protocols and materials databases

DNASUi 6370.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253451 ; ENSP00000253451 ; ENSG00000131142 . [O15444-3 ]
ENST00000390669 ; ENSP00000375086 ; ENSG00000131142 . [O15444-1 ]
GeneIDi 6370.
KEGGi hsa:6370.
UCSCi uc002mjc.4. human. [O15444-3 ]
uc002mjd.3. human. [O15444-1 ]

Organism-specific databases

CTDi 6370.
GeneCardsi GC19P008117.
H-InvDB HIX0039931.
HGNCi HGNC:10624. CCL25.
HPAi HPA055883.
MIMi 602565. gene.
neXtProti NX_O15444.
PharmGKBi PA35556.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39655.
GeneTreei ENSGT00510000049257.
HOGENOMi HOG000293281.
HOVERGENi HBG050832.
InParanoidi O15444.
KOi K13072.
OMAi AWAPAVH.
OrthoDBi EOG76MKB6.
PhylomeDBi O15444.
TreeFami TF353160.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii 6370.
NextBioi 24752.
PROi O15444.
SOURCEi Search...

Gene expression databases

Bgeei O15444.
CleanExi HS_CCL25.
ExpressionAtlasi O15444. baseline.
Genevestigatori O15444.

Family and domain databases

InterProi IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development."
    Vicari A.P., Figueroa D.J., Hedrick J.A., Foster J.S., Singh K.P., Menon S., Copeland N.G., Gilbert D.J., Jenkins N.A., Bacon K.B., Zlotnik A.
    Immunity 7:291-301(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-104.
    Tissue: Thymus.
  2. "Molecular cloning and characterization of a splicing variant of chemokine TECK: a natural antagonist of human TECK."
    Hieshima K., Nakayama T., Fujisawa R., Izawa D., Yoshie O.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Thymus.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Thymus.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Lung.
  7. "Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK."
    Zaballos A., Gutierrez J., Varona R., Ardavin C., Marquez G.
    J. Immunol. 162:5671-5675(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: RECEPTOR INTERACTION.
  8. "Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR."
    Watts A.O., Verkaar F., van der Lee M.M., Timmerman C.A., Kuijer M., van Offenbeek J., van Lith L.H., Smit M.J., Leurs R., Zaman G.J., Vischer H.F.
    J. Biol. Chem. 288:7169-7181(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: RECEPTOR INTERACTION.

Entry informationi

Entry nameiCCL25_HUMAN
AccessioniPrimary (citable) accession number: O15444
Secondary accession number(s): A1L4J4
, A6NI52, A8K9E7, B5MCA5, Q96KJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 22, 2008
Last modified: November 26, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3