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O15444

- CCL25_HUMAN

UniProt

O15444 - CCL25_HUMAN

Protein

C-C motif chemokine 25

Gene

CCL25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

    GO - Molecular functioni

    1. CCR10 chemokine receptor binding Source: BHF-UCL
    2. chemokine activity Source: ProtInc
    3. chemokine receptor binding Source: UniProtKB
    4. hormone activity Source: ProtInc

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. cell surface receptor signaling pathway Source: ProtInc
    3. chemotaxis Source: ProtInc
    4. G-protein coupled receptor signaling pathway Source: ProtInc
    5. immune response Source: ProtInc
    6. inflammatory response Source: UniProtKB-KW
    7. leukocyte migration Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 25
    Alternative name(s):
    Chemokine TECK
    Small-inducible cytokine A25
    Thymus-expressed chemokine
    Gene namesi
    Name:CCL25
    Synonyms:SCYA25, TECK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:10624. CCL25.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35556.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 150127C-C motif chemokine 25PRO_0000005235Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 58By similarity
    Disulfide bondi31 ↔ 75By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiO15444.
    PRIDEiO15444.

    PTM databases

    PhosphoSiteiO15444.

    Expressioni

    Tissue specificityi

    Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.

    Gene expression databases

    ArrayExpressiO15444.
    BgeeiO15444.
    CleanExiHS_CCL25.
    GenevestigatoriO15444.

    Organism-specific databases

    HPAiHPA055883.

    Interactioni

    Protein-protein interaction databases

    BioGridi112273. 1 interaction.
    DIPiDIP-5883N.
    IntActiO15444. 1 interaction.
    MINTiMINT-106224.
    STRINGi9606.ENSP00000375086.

    Structurei

    3D structure databases

    ProteinModelPortaliO15444.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39655.
    HOGENOMiHOG000293281.
    HOVERGENiHBG050832.
    KOiK13072.
    OMAiAWAPAVH.
    OrthoDBiEOG76MKB6.
    PhylomeDBiO15444.
    TreeFamiTF353160.

    Family and domain databases

    InterProiIPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O15444-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNLWLLACLV AGFLGAWAPA VHTQGVFEDC CLAYHYPIGW AVLRRAWTYR    50
    IQEVSGSCNL PAAIFYLPKR HRKVCGNPKS REVQRAMKLL DARNKVFAKL 100
    HHNTQTFQAG PHAVKKLSSG NSKLSSSKFS NPISSSKRNV SLLISANSGL 150
    Length:150
    Mass (Da):16,609
    Last modified:July 22, 2008 - v2
    Checksum:i91D0810F137FBC7B
    GO
    Isoform 2 (identifier: O15444-2) [UniParc]FASTAAdd to Basket

    Also known as: TECKvar

    The sequence of this isoform differs from the canonical sequence as follows:
         65-150: FYLPKRHRKV...SLLISANSGL → RPSCCKEVEFWKLQVIIIQV

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:84
    Mass (Da):9,496
    Checksum:i11307E0137B394D4
    GO
    Isoform 3 (identifier: O15444-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         109-109: Missing.

    Show »
    Length:149
    Mass (Da):16,538
    Checksum:iAC5468E6EF71986E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti23 – 231T → A.
    Corresponds to variant rs960173 [ dbSNP | Ensembl ].
    VAR_044519
    Natural varianti101 – 1011H → R.
    Corresponds to variant rs2032887 [ dbSNP | Ensembl ].
    VAR_044520
    Natural varianti104 – 1041T → M.1 Publication
    Corresponds to variant rs1129763 [ dbSNP | Ensembl ].
    VAR_044521

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei65 – 15086FYLPK…ANSGL → RPSCCKEVEFWKLQVIIIQV in isoform 2. 1 PublicationVSP_001064Add
    BLAST
    Alternative sequencei109 – 1091Missing in isoform 3. 2 PublicationsVSP_043199

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U86358 mRNA. Translation: AAB69981.1.
    AB046579 mRNA. Translation: BAB62257.1.
    AK292662 mRNA. Translation: BAF85351.1.
    AC008946 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW68952.1.
    BC130561 mRNA. Translation: AAI30562.1.
    BC144463 mRNA. Translation: AAI44464.1.
    CCDSiCCDS12194.1. [O15444-1]
    CCDS56080.1. [O15444-3]
    RefSeqiNP_001188288.1. NM_001201359.1. [O15444-3]
    NP_005615.2. NM_005624.3. [O15444-1]
    UniGeneiHs.310511.

    Genome annotation databases

    EnsembliENST00000253451; ENSP00000253451; ENSG00000131142. [O15444-3]
    ENST00000390669; ENSP00000375086; ENSG00000131142. [O15444-1]
    GeneIDi6370.
    KEGGihsa:6370.
    UCSCiuc002mjc.4. human. [O15444-3]
    uc002mjd.3. human. [O15444-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CCL25 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U86358 mRNA. Translation: AAB69981.1 .
    AB046579 mRNA. Translation: BAB62257.1 .
    AK292662 mRNA. Translation: BAF85351.1 .
    AC008946 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW68952.1 .
    BC130561 mRNA. Translation: AAI30562.1 .
    BC144463 mRNA. Translation: AAI44464.1 .
    CCDSi CCDS12194.1. [O15444-1 ]
    CCDS56080.1. [O15444-3 ]
    RefSeqi NP_001188288.1. NM_001201359.1. [O15444-3 ]
    NP_005615.2. NM_005624.3. [O15444-1 ]
    UniGenei Hs.310511.

    3D structure databases

    ProteinModelPortali O15444.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112273. 1 interaction.
    DIPi DIP-5883N.
    IntActi O15444. 1 interaction.
    MINTi MINT-106224.
    STRINGi 9606.ENSP00000375086.

    PTM databases

    PhosphoSitei O15444.

    Proteomic databases

    PaxDbi O15444.
    PRIDEi O15444.

    Protocols and materials databases

    DNASUi 6370.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253451 ; ENSP00000253451 ; ENSG00000131142 . [O15444-3 ]
    ENST00000390669 ; ENSP00000375086 ; ENSG00000131142 . [O15444-1 ]
    GeneIDi 6370.
    KEGGi hsa:6370.
    UCSCi uc002mjc.4. human. [O15444-3 ]
    uc002mjd.3. human. [O15444-1 ]

    Organism-specific databases

    CTDi 6370.
    GeneCardsi GC19P008117.
    H-InvDB HIX0039931.
    HGNCi HGNC:10624. CCL25.
    HPAi HPA055883.
    MIMi 602565. gene.
    neXtProti NX_O15444.
    PharmGKBi PA35556.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39655.
    HOGENOMi HOG000293281.
    HOVERGENi HBG050832.
    KOi K13072.
    OMAi AWAPAVH.
    OrthoDBi EOG76MKB6.
    PhylomeDBi O15444.
    TreeFami TF353160.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GenomeRNAii 6370.
    NextBioi 24752.
    PROi O15444.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15444.
    Bgeei O15444.
    CleanExi HS_CCL25.
    Genevestigatori O15444.

    Family and domain databases

    InterProi IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development."
      Vicari A.P., Figueroa D.J., Hedrick J.A., Foster J.S., Singh K.P., Menon S., Copeland N.G., Gilbert D.J., Jenkins N.A., Bacon K.B., Zlotnik A.
      Immunity 7:291-301(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-104.
      Tissue: Thymus.
    2. "Molecular cloning and characterization of a splicing variant of chemokine TECK: a natural antagonist of human TECK."
      Hieshima K., Nakayama T., Fujisawa R., Izawa D., Yoshie O.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Thymus.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Thymus.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Lung.
    7. "Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK."
      Zaballos A., Gutierrez J., Varona R., Ardavin C., Marquez G.
      J. Immunol. 162:5671-5675(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: RECEPTOR INTERACTION.
    8. "Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR."
      Watts A.O., Verkaar F., van der Lee M.M., Timmerman C.A., Kuijer M., van Offenbeek J., van Lith L.H., Smit M.J., Leurs R., Zaman G.J., Vischer H.F.
      J. Biol. Chem. 288:7169-7181(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: RECEPTOR INTERACTION.

    Entry informationi

    Entry nameiCCL25_HUMAN
    AccessioniPrimary (citable) accession number: O15444
    Secondary accession number(s): A1L4J4
    , A6NI52, A8K9E7, B5MCA5, Q96KJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3