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O15444 (CCL25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 25
Alternative name(s):
Chemokine TECK
Small-inducible cytokine A25
Thymus-expressed chemokine
Gene names
Name:CCL25
Synonyms:SCYA25, TECK
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length150 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Subcellular location

Secreted.

Tissue specificity

Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O15444-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O15444-2)

Also known as: TECKvar;

The sequence of this isoform differs from the canonical sequence as follows:
     65-150: FYLPKRHRKV...SLLISANSGL → RPSCCKEVEFWKLQVIIIQV
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 3 (identifier: O15444-3)

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 150127C-C motif chemokine 25
PRO_0000005235

Amino acid modifications

Disulfide bond30 ↔ 58 By similarity
Disulfide bond31 ↔ 75 By similarity

Natural variations

Alternative sequence65 – 15086FYLPK…ANSGL → RPSCCKEVEFWKLQVIIIQV in isoform 2.
VSP_001064
Alternative sequence1091Missing in isoform 3.
VSP_043199
Natural variant231T → A.
Corresponds to variant rs960173 [ dbSNP | Ensembl ].
VAR_044519
Natural variant1011H → R.
Corresponds to variant rs2032887 [ dbSNP | Ensembl ].
VAR_044520
Natural variant1041T → M. Ref.1
Corresponds to variant rs1129763 [ dbSNP | Ensembl ].
VAR_044521

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 22, 2008. Version 2.
Checksum: 91D0810F137FBC7B

FASTA15016,609
        10         20         30         40         50         60 
MNLWLLACLV AGFLGAWAPA VHTQGVFEDC CLAYHYPIGW AVLRRAWTYR IQEVSGSCNL 

        70         80         90        100        110        120 
PAAIFYLPKR HRKVCGNPKS REVQRAMKLL DARNKVFAKL HHNTQTFQAG PHAVKKLSSG 

       130        140        150 
NSKLSSSKFS NPISSSKRNV SLLISANSGL 

« Hide

Isoform 2 (TECKvar) [UniParc].

Checksum: 11307E0137B394D4
Show »

FASTA849,496
Isoform 3 [UniParc].

Checksum: AC5468E6EF71986E
Show »

FASTA14916,538

References

« Hide 'large scale' references
[1]"TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development."
Vicari A.P., Figueroa D.J., Hedrick J.A., Foster J.S., Singh K.P., Menon S., Copeland N.G., Gilbert D.J., Jenkins N.A., Bacon K.B., Zlotnik A.
Immunity 7:291-301(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-104.
Tissue: Thymus.
[2]"Molecular cloning and characterization of a splicing variant of chemokine TECK: a natural antagonist of human TECK."
Hieshima K., Nakayama T., Fujisawa R., Izawa D., Yoshie O.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Thymus.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Thymus.
[4]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Lung.
[7]"Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK."
Zaballos A., Gutierrez J., Varona R., Ardavin C., Marquez G.
J. Immunol. 162:5671-5675(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: RECEPTOR INTERACTION.
[8]"Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR."
Watts A.O., Verkaar F., van der Lee M.M., Timmerman C.A., Kuijer M., van Offenbeek J., van Lith L.H., Smit M.J., Leurs R., Zaman G.J., Vischer H.F.
J. Biol. Chem. 288:7169-7181(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: RECEPTOR INTERACTION.
+Additional computationally mapped references.

Web resources

Wikipedia

CCL25 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U86358 mRNA. Translation: AAB69981.1.
AB046579 mRNA. Translation: BAB62257.1.
AK292662 mRNA. Translation: BAF85351.1.
AC008946 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW68952.1.
BC130561 mRNA. Translation: AAI30562.1.
BC144463 mRNA. Translation: AAI44464.1.
CCDSCCDS12194.1. [O15444-1]
CCDS56080.1. [O15444-3]
RefSeqNP_001188288.1. NM_001201359.1. [O15444-3]
NP_005615.2. NM_005624.3. [O15444-1]
UniGeneHs.310511.

3D structure databases

ProteinModelPortalO15444.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112273. 1 interaction.
DIPDIP-5883N.
IntActO15444. 1 interaction.
MINTMINT-106224.
STRING9606.ENSP00000375086.

PTM databases

PhosphoSiteO15444.

Proteomic databases

PaxDbO15444.
PRIDEO15444.

Protocols and materials databases

DNASU6370.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000253451; ENSP00000253451; ENSG00000131142. [O15444-3]
ENST00000390669; ENSP00000375086; ENSG00000131142. [O15444-1]
GeneID6370.
KEGGhsa:6370.
UCSCuc002mjc.4. human. [O15444-3]
uc002mjd.3. human. [O15444-1]

Organism-specific databases

CTD6370.
GeneCardsGC19P008117.
H-InvDBHIX0039931.
HGNCHGNC:10624. CCL25.
HPAHPA055883.
MIM602565. gene.
neXtProtNX_O15444.
PharmGKBPA35556.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39655.
HOGENOMHOG000293281.
HOVERGENHBG050832.
KOK13072.
OMAAWAPAVH.
OrthoDBEOG76MKB6.
PhylomeDBO15444.
TreeFamTF353160.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressO15444.
BgeeO15444.
CleanExHS_CCL25.
GenevestigatorO15444.

Family and domain databases

InterProIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi6370.
NextBio24752.
PROO15444.
SOURCESearch...

Entry information

Entry nameCCL25_HUMAN
AccessionPrimary (citable) accession number: O15444
Secondary accession number(s): A1L4J4 expand/collapse secondary AC list , A6NI52, A8K9E7, B5MCA5, Q96KJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 22, 2008
Last modified: July 9, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM