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Protein

Metallophosphoesterase domain-containing protein 1

Gene

MPPED1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have metallophosphoesterase activity (in vitro).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Metallophosphoesterase domain-containing protein 1 (EC:3.1.-.-)
Alternative name(s):
Adult brain protein 239
Short name:
239AB
Gene namesi
Name:MPPED1
Synonyms:C22orf1, FAM1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:1306. MPPED1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25880.

Polymorphism and mutation databases

BioMutaiMPPED1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Metallophosphoesterase domain-containing protein 1PRO_0000053403Add
BLAST

Proteomic databases

PaxDbiO15442.
PeptideAtlasiO15442.
PRIDEiO15442.

Expressioni

Tissue specificityi

Expressed predominantly in adult brain.

Gene expression databases

BgeeiO15442.
CleanExiHS_MPPED1.
ExpressionAtlasiO15442. baseline and differential.
GenevisibleiO15442. HS.

Interactioni

Protein-protein interaction databases

BioGridi107213. 27 interactions.
IntActiO15442. 3 interactions.
MINTiMINT-8247357.
STRINGi9606.ENSP00000388137.

Structurei

3D structure databases

ProteinModelPortaliO15442.
SMRiO15442. Positions 43-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0046 family.Curated

Phylogenomic databases

eggNOGiKOG3947. Eukaryota.
ENOG4111K47. LUCA.
GeneTreeiENSGT00390000007681.
HOGENOMiHOG000023302.
HOVERGENiHBG000008.
InParanoidiO15442.
OMAiRSMWRAR.
OrthoDBiEOG7G4QFH.
PhylomeDBiO15442.
TreeFamiTF314305.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR024201. Calcineurin-like_Pesterase.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF035808. Pdiesterase_Brain_239. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15442-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWRSRWDASV LKAEALALLP CGLGMAFSQS HVMAARRHQH SRLIIEVDEY
60 70 80 90 100
SSNPTQAFTF YNINQGRFQP PHVQMVDPVP HDAPKPPGYT RFVCVSDTHS
110 120 130 140 150
RTDPIQMPYG DVLIHAGDFT ELGLPSEVKK FNEWLGSLPY EYKIVIAGNH
160 170 180 190 200
ELTFDQEFMA DLIKQDFYYF PSVSKLKPEN YENVQSLLTN CIYLQDSEVT
210 220 230 240 250
VRGFRIYGSP WQPWFYGWGF NLPRGQALLE KWNLIPEGVD ILITHGPPLG
260 270 280 290 300
FLDWVPKKMQ RVGCVELLNT VQRRVQPRLH VFGHIHEGYG VMADGTTTYV
310 320
NASVCTVNYQ PVNPPIVIDL PTPRNS
Length:326
Mass (Da):37,207
Last modified:July 5, 2005 - v3
Checksum:i462265716D3AA1E2
GO
Isoform 2 (identifier: O15442-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNGRETQSVSRSGGGPGCGGGSGGRCRGGRRRSM

Note: No experimental confirmation available.
Show »
Length:359
Mass (Da):40,427
Checksum:i5E4941B7120E963E
GO

Sequence cautioni

The sequence AAC51673.2 differs from that shown. Reason: Frameshift at position 20. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MNGRETQSVSRSGGGPGCGG GSGGRCRGGRRRSM in isoform 2. 1 PublicationVSP_056871

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84894 mRNA. Translation: AAC51673.2. Frameshift.
AK289774 mRNA. Translation: BAF82463.1.
AK290541 mRNA. Translation: BAF83230.1.
AK294912 mRNA. Translation: BAG57999.1.
AK295077 mRNA. Translation: BAH11965.1.
CU137653
, AL049708, AL096759, BX546033, CR377231, Z82172 Genomic DNA. Translation: CAQ06857.1.
AL049708
, AL096759, BX546033, CR377231, CU137653, Z82172 Genomic DNA. Translation: CAQ08121.1.
CR377231
, AL049708, AL096759, BX546033, CU137653, Z82172 Genomic DNA. Translation: CAQ08182.1.
BX546033
, AL049708, AL096759, CR377231, CU137653, Z82172 Genomic DNA. Translation: CAQ08847.1.
Z82172
, AL049708, AL096759, BX546033, CR377231, CU137653 Genomic DNA. Translation: CAQ10809.1.
BC028035 mRNA. Translation: AAH28035.1.
CCDSiCCDS46723.1. [O15442-1]
RefSeqiNP_001037835.1. NM_001044370.1. [O15442-1]
XP_011528669.1. XM_011530367.1. [O15442-1]
UniGeneiHs.159538.

Genome annotation databases

EnsembliENST00000417669; ENSP00000388137; ENSG00000186732. [O15442-1]
ENST00000443721; ENSP00000400686; ENSG00000186732. [O15442-1]
GeneIDi758.
KEGGihsa:758.
UCSCiuc011apv.3. human. [O15442-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84894 mRNA. Translation: AAC51673.2. Frameshift.
AK289774 mRNA. Translation: BAF82463.1.
AK290541 mRNA. Translation: BAF83230.1.
AK294912 mRNA. Translation: BAG57999.1.
AK295077 mRNA. Translation: BAH11965.1.
CU137653
, AL049708, AL096759, BX546033, CR377231, Z82172 Genomic DNA. Translation: CAQ06857.1.
AL049708
, AL096759, BX546033, CR377231, CU137653, Z82172 Genomic DNA. Translation: CAQ08121.1.
CR377231
, AL049708, AL096759, BX546033, CU137653, Z82172 Genomic DNA. Translation: CAQ08182.1.
BX546033
, AL049708, AL096759, CR377231, CU137653, Z82172 Genomic DNA. Translation: CAQ08847.1.
Z82172
, AL049708, AL096759, BX546033, CR377231, CU137653 Genomic DNA. Translation: CAQ10809.1.
BC028035 mRNA. Translation: AAH28035.1.
CCDSiCCDS46723.1. [O15442-1]
RefSeqiNP_001037835.1. NM_001044370.1. [O15442-1]
XP_011528669.1. XM_011530367.1. [O15442-1]
UniGeneiHs.159538.

3D structure databases

ProteinModelPortaliO15442.
SMRiO15442. Positions 43-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107213. 27 interactions.
IntActiO15442. 3 interactions.
MINTiMINT-8247357.
STRINGi9606.ENSP00000388137.

Polymorphism and mutation databases

BioMutaiMPPED1.

Proteomic databases

PaxDbiO15442.
PeptideAtlasiO15442.
PRIDEiO15442.

Protocols and materials databases

DNASUi758.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000417669; ENSP00000388137; ENSG00000186732. [O15442-1]
ENST00000443721; ENSP00000400686; ENSG00000186732. [O15442-1]
GeneIDi758.
KEGGihsa:758.
UCSCiuc011apv.3. human. [O15442-1]

Organism-specific databases

CTDi758.
GeneCardsiMPPED1.
HGNCiHGNC:1306. MPPED1.
MIMi602112. gene.
neXtProtiNX_O15442.
PharmGKBiPA25880.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3947. Eukaryota.
ENOG4111K47. LUCA.
GeneTreeiENSGT00390000007681.
HOGENOMiHOG000023302.
HOVERGENiHBG000008.
InParanoidiO15442.
OMAiRSMWRAR.
OrthoDBiEOG7G4QFH.
PhylomeDBiO15442.
TreeFamiTF314305.

Miscellaneous databases

GenomeRNAii758.
PROiO15442.
SOURCEiSearch...

Gene expression databases

BgeeiO15442.
CleanExiHS_MPPED1.
ExpressionAtlasiO15442. baseline and differential.
GenevisibleiO15442. HS.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR024201. Calcineurin-like_Pesterase.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF035808. Pdiesterase_Brain_239. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The 239AB gene on chromosome 22: a novel member of an ancient gene family."
    Schwartz F., Ota T.
    Gene 194:57-62(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiMPPD1_HUMAN
AccessioniPrimary (citable) accession number: O15442
Secondary accession number(s): A8K159, B7Z2S9, Q8N361
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 5, 2005
Last modified: July 6, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.