Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Metallophosphoesterase domain-containing protein 1

Gene

MPPED1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have metallophosphoesterase activity (in vitro).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Metallophosphoesterase domain-containing protein 1 (EC:3.1.-.-)
Alternative name(s):
Adult brain protein 239
Short name:
239AB
Gene namesi
Name:MPPED1
Synonyms:C22orf1, FAM1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000186732.13
HGNCiHGNC:1306 MPPED1
MIMi602112 gene
neXtProtiNX_O15442

Pathology & Biotechi

Organism-specific databases

DisGeNETi758
OpenTargetsiENSG00000186732
PharmGKBiPA25880

Polymorphism and mutation databases

BioMutaiMPPED1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534031 – 326Metallophosphoesterase domain-containing protein 1Add BLAST326

Proteomic databases

PaxDbiO15442
PeptideAtlasiO15442
PRIDEiO15442
ProteomicsDBi48671

PTM databases

PhosphoSitePlusiO15442

Expressioni

Tissue specificityi

Expressed predominantly in adult brain.

Gene expression databases

BgeeiENSG00000186732
CleanExiHS_MPPED1
ExpressionAtlasiO15442 baseline and differential
GenevisibleiO15442 HS

Interactioni

Protein-protein interaction databases

BioGridi107213, 28 interactors
IntActiO15442, 4 interactors
MINTiO15442
STRINGi9606.ENSP00000388137

Structurei

3D structure databases

ProteinModelPortaliO15442
SMRiO15442
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0046 family.Curated

Phylogenomic databases

eggNOGiKOG3947 Eukaryota
ENOG4111K47 LUCA
GeneTreeiENSGT00390000007681
HOGENOMiHOG000023302
HOVERGENiHBG000008
InParanoidiO15442
OMAiHEGYGIS
OrthoDBiEOG091G0CE0
PhylomeDBiO15442
TreeFamiTF314305

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR024201 Calcineurin-like_Pesterase
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PIRSFiPIRSF035808 Pdiesterase_Brain_239, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15442-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWRSRWDASV LKAEALALLP CGLGMAFSQS HVMAARRHQH SRLIIEVDEY
60 70 80 90 100
SSNPTQAFTF YNINQGRFQP PHVQMVDPVP HDAPKPPGYT RFVCVSDTHS
110 120 130 140 150
RTDPIQMPYG DVLIHAGDFT ELGLPSEVKK FNEWLGSLPY EYKIVIAGNH
160 170 180 190 200
ELTFDQEFMA DLIKQDFYYF PSVSKLKPEN YENVQSLLTN CIYLQDSEVT
210 220 230 240 250
VRGFRIYGSP WQPWFYGWGF NLPRGQALLE KWNLIPEGVD ILITHGPPLG
260 270 280 290 300
FLDWVPKKMQ RVGCVELLNT VQRRVQPRLH VFGHIHEGYG VMADGTTTYV
310 320
NASVCTVNYQ PVNPPIVIDL PTPRNS
Length:326
Mass (Da):37,207
Last modified:July 5, 2005 - v3
Checksum:i462265716D3AA1E2
GO
Isoform 2 (identifier: O15442-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNGRETQSVSRSGGGPGCGGGSGGRCRGGRRRSM

Note: No experimental confirmation available.
Show »
Length:359
Mass (Da):40,427
Checksum:i5E4941B7120E963E
GO

Sequence cautioni

The sequence AAC51673 differs from that shown. Reason: Frameshift at position 20.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0568711M → MNGRETQSVSRSGGGPGCGG GSGGRCRGGRRRSM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84894 mRNA Translation: AAC51673.2 Frameshift.
AK289774 mRNA Translation: BAF82463.1
AK290541 mRNA Translation: BAF83230.1
AK294912 mRNA Translation: BAG57999.1
AK295077 mRNA Translation: BAH11965.1
CU137653
, AL049708, AL096759, BX546033, CR377231, Z82172 Genomic DNA Translation: CAQ06857.1
AL049708
, AL096759, BX546033, CR377231, CU137653, Z82172 Genomic DNA Translation: CAQ08121.1
CR377231
, AL049708, AL096759, BX546033, CU137653, Z82172 Genomic DNA Translation: CAQ08182.1
BX546033
, AL049708, AL096759, CR377231, CU137653, Z82172 Genomic DNA Translation: CAQ08847.1
Z82172
, AL049708, AL096759, BX546033, CR377231, CU137653 Genomic DNA Translation: CAQ10809.1
BC028035 mRNA Translation: AAH28035.1
CCDSiCCDS46723.1 [O15442-1]
RefSeqiNP_001037835.1, NM_001044370.1 [O15442-1]
XP_011528669.1, XM_011530367.2 [O15442-1]
UniGeneiHs.159538

Genome annotation databases

EnsembliENST00000417669; ENSP00000388137; ENSG00000186732 [O15442-1]
ENST00000443721; ENSP00000400686; ENSG00000186732 [O15442-1]
GeneIDi758
KEGGihsa:758
UCSCiuc011apv.3 human [O15442-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMPPD1_HUMAN
AccessioniPrimary (citable) accession number: O15442
Secondary accession number(s): A8K159, B7Z2S9, Q8N361
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 5, 2005
Last modified: June 20, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health