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O15440

- MRP5_HUMAN

UniProt

O15440 - MRP5_HUMAN

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Protein
Multidrug resistance-associated protein 5
Gene
ABCC5, MRP5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a multispecific organic anion pump which can transport nucleotide analogs.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi595 – 6028ATP 1 Reviewed prediction
Nucleotide bindingi1227 – 12348ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  3. organic anion transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. glycosaminoglycan metabolic process Source: Reactome
  3. hyaluronan biosynthetic process Source: Reactome
  4. hyaluronan metabolic process Source: Reactome
  5. organic anion transport Source: GOC
  6. small molecule metabolic process Source: Reactome
  7. transmembrane transport Source: Reactome
  8. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_121301. Hyaluronan biosynthesis and export.
REACT_15480. ABC-family proteins mediated transport.

Protein family/group databases

TCDBi3.A.1.208.15. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 5
Alternative name(s):
ATP-binding cassette sub-family C member 5
Multi-specific organic anion transporter C
Short name:
MOAT-C
SMRP
pABC11
Gene namesi
Name:ABCC5
Synonyms:MRP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:56. ABCC5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei179 – 19921Helical; Reviewed prediction
Add
BLAST
Transmembranei219 – 23921Helical; Reviewed prediction
Add
BLAST
Transmembranei296 – 31621Helical; Reviewed prediction
Add
BLAST
Transmembranei317 – 33721Helical; Reviewed prediction
Add
BLAST
Transmembranei400 – 42021Helical; Reviewed prediction
Add
BLAST
Transmembranei434 – 45421Helical; Reviewed prediction
Add
BLAST
Transmembranei608 – 62821Helical; Reviewed prediction
Add
BLAST
Transmembranei848 – 86821Helical; Reviewed prediction
Add
BLAST
Transmembranei917 – 93721Helical; Reviewed prediction
Add
BLAST
Transmembranei997 – 101721Helical; Reviewed prediction
Add
BLAST
Transmembranei1018 – 103821Helical; Reviewed prediction
Add
BLAST
Transmembranei1104 – 112421Helical; Reviewed prediction
Add
BLAST
Transmembranei1127 – 114721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: MGI
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA395.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14371437Multidrug resistance-associated protein 5
PRO_0000093363Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi494 – 4941N-linked (GlcNAc...) Reviewed prediction
Modified residuei509 – 5091Phosphoserine2 Publications
Modified residuei513 – 5131Phosphothreonine1 Publication
Glycosylationi636 – 6361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi684 – 6841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi890 – 8901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi897 – 8971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1044 – 10441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1329 – 13291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1417 – 14171N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO15440.
PaxDbiO15440.
PRIDEiO15440.

PTM databases

PhosphoSiteiO15440.

Expressioni

Tissue specificityi

All isoforms are equally expressed in retina.1 Publication

Gene expression databases

ArrayExpressiO15440.
BgeeiO15440.
CleanExiHS_ABCC5.
GenevestigatoriO15440.

Organism-specific databases

HPAiHPA052295.

Interactioni

Protein-protein interaction databases

BioGridi115368. 5 interactions.
IntActiO15440. 5 interactions.
STRINGi9606.ENSP00000333926.

Structurei

3D structure databases

ProteinModelPortaliO15440.
SMRiO15440. Positions 532-843, 858-1433.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini179 – 459281ABC transmembrane type-1 1
Add
BLAST
Domaini562 – 783222ABC transporter 1
Add
BLAST
Domaini859 – 1155297ABC transmembrane type-1 2
Add
BLAST
Domaini1193 – 1427235ABC transporter 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
HOGENOMiHOG000116132.
HOVERGENiHBG108314.
InParanoidiO15440.
KOiK05668.
OMAiVIMALFM.
OrthoDBiEOG7MWGW0.
PhylomeDBiO15440.
TreeFamiTF105202.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O15440-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL     50
ETAARAEGLS LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP 100
VDNAGLFSCM TFSWLSSLAR VAHKKGELSM EDVWSLSKHE SSDVNCRRLE 150
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPAFM 200
VKHLLEYTQA TESNLQYSLL LVLGLLLTEI VRSWSLALTW ALNYRTGVRL 250
RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG 300
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFASRLT AYFRRKCVAA 350
TDERVQKMNE VLTYIKFIKM YAWVKAFSQS VQKIREEERR ILEKAGYFQS 400
ITVGVAPIVV VIASVVTFSV HMTLGFDLTA AQAFTVVTVF NSMTFALKVT 450
PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK NKPASPHIKI EMKNATLAWD 500
SSHSSIQNSP KLTPKMKKDK RASRGKKEKV RQLQRTEHQA VLAEQKGHLL 550
LDSDERPSPE EEEGKHIHLG HLRLQRTLHS IDLEIQEGKL VGICGSVGSG 600
KTSLISAILG QMTLLEGSIA ISGTFAYVAQ QAWILNATLR DNILFGKEYD 650
EERYNSVLNS CCLRPDLAIL PSSDLTEIGE RGANLSGGQR QRISLARALY 700
SDRSIYILDD PLSALDAHVG NHIFNSAIRK HLKSKTVLFV THQLQYLVDC 750
DEVIFMKEGC ITERGTHEEL MNLNGDYATI FNNLLLGETP PVEINSKKET 800
SGSQKKSQDK GPKTGSVKKE KAVKPEEGQL VQLEEKGQGS VPWSVYGVYI 850
QAAGGPLAFL VIMALFMLNV GSTAFSTWWL SYWIKQGSGN TTVTRGNETS 900
VSDSMKDNPH MQYYASIYAL SMAVMLILKA IRGVVFVKGT LRASSRLHDE 950
LFRRILRSPM KFFDTTPTGR ILNRFSKDMD EVDVRLPFQA EMFIQNVILV 1000
FFCVGMIAGV FPWFLVAVGP LVILFSVLHI VSRVLIRELK RLDNITQSPF 1050
LSHITSSIQG LATIHAYNKG QEFLHRYQEL LDDNQAPFFL FTCAMRWLAV 1100
RLDLISIALI TTTGLMIVLM HGQIPPAYAG LAISYAVQLT GLFQFTVRLA 1150
SETEARFTSV ERINHYIKTL SLEAPARIKN KAPSPDWPQE GEVTFENAEM 1200
RYRENLPLVL KKVSFTIKPK EKIGIVGRTG SGKSSLGMAL FRLVELSGGC 1250
IKIDGVRISD IGLADLRSKL SIIPQEPVLF SGTVRSNLDP FNQYTEDQIW 1300
DALERTHMKE CIAQLPLKLE SEVMENGDNF SVGERQLLCI ARALLRHCKI 1350
LILDEATAAM DTETDLLIQE TIREAFADCT MLTIAHRLHT VLGSDRIMVL 1400
AQGQVVEFDT PSVLLSNDSS RFYAMFAAAE NKVAVKG 1437
Length:1,437
Mass (Da):160,660
Last modified:December 1, 2000 - v2
Checksum:i00558076B3BB4C00
GO
Isoform 2 (identifier: O15440-2) [UniParc]FASTAAdd to Basket

Also known as: SV1

The sequence of this isoform differs from the canonical sequence as follows:
     198-225: AFMVKHLLEYTQATESNLQYSLLLVLGL → PSFGDCSISAEVCGNRLHCTAILLSCFT
     226-1437: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:225
Mass (Da):25,341
Checksum:i771FBD2C32E08B8C
GO
Isoform 3 (identifier: O15440-3) [UniParc]FASTAAdd to Basket

Also known as: SV2

The sequence of this isoform differs from the canonical sequence as follows:
     198-212: AFMVKHLLEYTQATE → LAWCCQDLDLGGVSL
     213-225: Missing.
     226-1437: Missing.

Note: Predominant isoform in retinal pigment epithelium, bladder, and stomach.

Show »
Length:212
Mass (Da):23,988
Checksum:iD562C6FBF01922D1
GO
Isoform 4 (identifier: O15440-4) [UniParc]FASTAAdd to Basket

Also known as: SV3

The sequence of this isoform differs from the canonical sequence as follows:
     198-208: AFMVKHLLEYT → NFQDGCILRSE
     209-225: Missing.
     226-1437: Missing.

Show »
Length:208
Mass (Da):23,677
Checksum:i3FF375FBCE128270
GO
Isoform 5 (identifier: O15440-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1033-1075: Missing.

Show »
Length:1,394
Mass (Da):155,732
Checksum:i5B11EC10EB9D07C9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei198 – 22528AFMVK…LVLGL → PSFGDCSISAEVCGNRLHCT AILLSCFT in isoform 2.
VSP_043397Add
BLAST
Alternative sequencei198 – 21215AFMVK…TQATE → LAWCCQDLDLGGVSL in isoform 3.
VSP_043398Add
BLAST
Alternative sequencei198 – 20811AFMVKHLLEYT → NFQDGCILRSE in isoform 4.
VSP_043399Add
BLAST
Alternative sequencei209 – 22517Missing in isoform 4.
VSP_043400Add
BLAST
Alternative sequencei213 – 22513Missing in isoform 3.
VSP_043401Add
BLAST
Alternative sequencei226 – 14371212Missing in isoform 2, isoform 3 and isoform 4.
VSP_043402Add
BLAST
Alternative sequencei1033 – 107543Missing in isoform 5.
VSP_055354Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti176 – 1761R → P in BAA76608. 1 Publication
Sequence conflicti400 – 4001S → G in AAD04169. 1 Publication
Sequence conflicti581 – 5811I → V in AAD37716. 1 Publication
Sequence conflicti1383 – 13831T → N in BAA76608. 1 Publication
Sequence conflicti1383 – 13831T → N in BAA22887. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF104942 mRNA. Translation: AAD04169.1.
AF146074 mRNA. Translation: AAD37716.1.
AB019002 mRNA. Translation: BAA76608.1.
U83661 mRNA. Translation: AAB71758.2.
AY754874 mRNA. Translation: AAW82948.1.
AY754875 mRNA. Translation: AAW82949.1.
AY754876 mRNA. Translation: AAW82950.1.
AY196484 mRNA. Translation: AAO49801.1.
AC068644 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78307.1.
CH471052 Genomic DNA. Translation: EAW78308.1.
BC050744 mRNA. Translation: AAH50744.1.
BC140771 mRNA. Translation: AAI40772.1.
BC142719 mRNA. Translation: AAI42720.1.
AB005659 mRNA. Translation: BAA22887.1.
CCDSiCCDS33898.1. [O15440-4]
CCDS43176.1. [O15440-1]
PIRiJC5667.
RefSeqiNP_001018881.1. NM_001023587.1. [O15440-4]
NP_005679.2. NM_005688.2. [O15440-1]
XP_005247115.1. XM_005247058.2. [O15440-1]
XP_005247116.1. XM_005247059.2. [O15440-1]
UniGeneiHs.368563.
Hs.743953.

Genome annotation databases

EnsembliENST00000265586; ENSP00000265586; ENSG00000114770.
ENST00000334444; ENSP00000333926; ENSG00000114770. [O15440-1]
ENST00000382494; ENSP00000371934; ENSG00000114770. [O15440-4]
ENST00000392579; ENSP00000376358; ENSG00000114770. [O15440-2]
ENST00000443376; ENSP00000416840; ENSG00000114770. [O15440-3]
GeneIDi10057.
KEGGihsa:10057.
UCSCiuc003fmg.3. human. [O15440-1]
uc003fmh.3. human. [O15440-4]
uc010hxn.3. human. [O15440-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF104942 mRNA. Translation: AAD04169.1 .
AF146074 mRNA. Translation: AAD37716.1 .
AB019002 mRNA. Translation: BAA76608.1 .
U83661 mRNA. Translation: AAB71758.2 .
AY754874 mRNA. Translation: AAW82948.1 .
AY754875 mRNA. Translation: AAW82949.1 .
AY754876 mRNA. Translation: AAW82950.1 .
AY196484 mRNA. Translation: AAO49801.1 .
AC068644 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78307.1 .
CH471052 Genomic DNA. Translation: EAW78308.1 .
BC050744 mRNA. Translation: AAH50744.1 .
BC140771 mRNA. Translation: AAI40772.1 .
BC142719 mRNA. Translation: AAI42720.1 .
AB005659 mRNA. Translation: BAA22887.1 .
CCDSi CCDS33898.1. [O15440-4 ]
CCDS43176.1. [O15440-1 ]
PIRi JC5667.
RefSeqi NP_001018881.1. NM_001023587.1. [O15440-4 ]
NP_005679.2. NM_005688.2. [O15440-1 ]
XP_005247115.1. XM_005247058.2. [O15440-1 ]
XP_005247116.1. XM_005247059.2. [O15440-1 ]
UniGenei Hs.368563.
Hs.743953.

3D structure databases

ProteinModelPortali O15440.
SMRi O15440. Positions 532-843, 858-1433.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115368. 5 interactions.
IntActi O15440. 5 interactions.
STRINGi 9606.ENSP00000333926.

Chemistry

ChEMBLi CHEMBL2046258.

Protein family/group databases

TCDBi 3.A.1.208.15. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSitei O15440.

Proteomic databases

MaxQBi O15440.
PaxDbi O15440.
PRIDEi O15440.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265586 ; ENSP00000265586 ; ENSG00000114770 .
ENST00000334444 ; ENSP00000333926 ; ENSG00000114770 . [O15440-1 ]
ENST00000382494 ; ENSP00000371934 ; ENSG00000114770 . [O15440-4 ]
ENST00000392579 ; ENSP00000376358 ; ENSG00000114770 . [O15440-2 ]
ENST00000443376 ; ENSP00000416840 ; ENSG00000114770 . [O15440-3 ]
GeneIDi 10057.
KEGGi hsa:10057.
UCSCi uc003fmg.3. human. [O15440-1 ]
uc003fmh.3. human. [O15440-4 ]
uc010hxn.3. human. [O15440-2 ]

Organism-specific databases

CTDi 10057.
GeneCardsi GC03M183637.
HGNCi HGNC:56. ABCC5.
HPAi HPA052295.
MIMi 605251. gene.
neXtProti NX_O15440.
PharmGKBi PA395.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1132.
HOGENOMi HOG000116132.
HOVERGENi HBG108314.
InParanoidi O15440.
KOi K05668.
OMAi VIMALFM.
OrthoDBi EOG7MWGW0.
PhylomeDBi O15440.
TreeFami TF105202.

Enzyme and pathway databases

Reactomei REACT_121301. Hyaluronan biosynthesis and export.
REACT_15480. ABC-family proteins mediated transport.

Miscellaneous databases

ChiTaRSi ABCC5. human.
GeneWikii ABCC5.
GenomeRNAii 10057.
NextBioi 37997.
PROi O15440.
SOURCEi Search...

Gene expression databases

ArrayExpressi O15440.
Bgeei O15440.
CleanExi HS_ABCC5.
Genevestigatori O15440.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins."
    Belinsky M.G., Bain L.J., Balsara B.B., Testa J.R., Kruh G.D.
    J. Natl. Cancer Inst. 90:1735-1741(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells."
    McAleer M.A., Breen M.A., White N.L., Matthews N.
    J. Biol. Chem. 274:23541-23548(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts."
    Suzuki T., Sasaki H., Kuh H.J., Agui M., Tatsumi Y., Tanabe S., Terada M., Saijo N., Nishio K.
    Gene 242:167-173(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs."
    Wijnholds J., Mol C.A.A.M., van Deemter L., de Haas M., Scheffer G.L., Baas F., Beijnen J.H., Scheper R.J., Hatse S., De Clercq E., Balzarini J., Borst P.
    Proc. Natl. Acad. Sci. U.S.A. 97:7476-7481(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    Tissue: Brain and Ovarian carcinoma.
  5. "Three novel ABCC5 splice variants in human retina and their role as regulators of ABCC5 gene expression."
    Stojic J., Stohr H., Weber B.H.
    BMC Mol. Biol. 8:42-42(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    Tissue: Retina.
  6. Ito T., Kato R., Ishikawa T.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    Tissue: Skeletal muscle.
  7. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Pancreas.
  10. "cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line."
    Suzuki T., Nishio K., Sasaki H., Kurokawa H., Saito-Ohara F., Ikeuch T., Tanabe S., Terada M., Saijo N.
    Biochem. Biophys. Res. Commun. 238:790-794(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 492-1437 (ISOFORM 1).
    Tissue: Bone marrow.
  11. "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines."
    Kool M., de Haas M., Scheffer G.L., Scheper R.J., van Eijk M.J., Juijn J.A., Baas F., Borst P.
    Cancer Res. 57:3537-3547(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1216-1437 (ISOFORM 1).
    Tissue: Brain.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509 AND THR-513, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiMRP5_HUMAN
AccessioniPrimary (citable) accession number: O15440
Secondary accession number(s): B9EIQ2
, O14517, Q29ZA9, Q29ZB1, Q86UX3, Q86W30, Q9UN85, Q9UNP5, Q9UQC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: September 3, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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