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O15440

- MRP5_HUMAN

UniProt

O15440 - MRP5_HUMAN

Protein

Multidrug resistance-associated protein 5

Gene

ABCC5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Acts as a multispecific organic anion pump which can transport nucleotide analogs.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi595 – 6028ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1227 – 12348ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: ProtInc
    3. organic anion transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. glycosaminoglycan metabolic process Source: Reactome
    3. hyaluronan biosynthetic process Source: Reactome
    4. hyaluronan metabolic process Source: Reactome
    5. organic anion transport Source: GOC
    6. small molecule metabolic process Source: Reactome
    7. transmembrane transport Source: Reactome
    8. transport Source: ProtInc

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_121301. Hyaluronan biosynthesis and export.
    REACT_15480. ABC-family proteins mediated transport.

    Protein family/group databases

    TCDBi3.A.1.208.15. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug resistance-associated protein 5
    Alternative name(s):
    ATP-binding cassette sub-family C member 5
    Multi-specific organic anion transporter C
    Short name:
    MOAT-C
    SMRP
    pABC11
    Gene namesi
    Name:ABCC5
    Synonyms:MRP5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:56. ABCC5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: MGI
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA395.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14371437Multidrug resistance-associated protein 5PRO_0000093363Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi494 – 4941N-linked (GlcNAc...)Sequence Analysis
    Modified residuei509 – 5091Phosphoserine2 Publications
    Modified residuei513 – 5131Phosphothreonine1 Publication
    Glycosylationi636 – 6361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi684 – 6841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi890 – 8901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi897 – 8971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1044 – 10441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1329 – 13291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1417 – 14171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO15440.
    PaxDbiO15440.
    PRIDEiO15440.

    PTM databases

    PhosphoSiteiO15440.

    Expressioni

    Tissue specificityi

    All isoforms are equally expressed in retina.1 Publication

    Gene expression databases

    ArrayExpressiO15440.
    BgeeiO15440.
    CleanExiHS_ABCC5.
    GenevestigatoriO15440.

    Organism-specific databases

    HPAiHPA052295.

    Interactioni

    Protein-protein interaction databases

    BioGridi115368. 5 interactions.
    IntActiO15440. 5 interactions.
    STRINGi9606.ENSP00000333926.

    Structurei

    3D structure databases

    ProteinModelPortaliO15440.
    SMRiO15440. Positions 532-843, 858-1433.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei179 – 19921HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei219 – 23921HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei296 – 31621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei317 – 33721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei400 – 42021HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei434 – 45421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei608 – 62821HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei848 – 86821HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei917 – 93721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei997 – 101721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1018 – 103821HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1104 – 112421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1127 – 114721HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini179 – 459281ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini562 – 783222ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini859 – 1155297ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1193 – 1427235ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    HOGENOMiHOG000116132.
    HOVERGENiHBG108314.
    InParanoidiO15440.
    KOiK05668.
    OMAiVIMALFM.
    OrthoDBiEOG7MWGW0.
    PhylomeDBiO15440.
    TreeFamiTF105202.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O15440-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL     50
    ETAARAEGLS LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP 100
    VDNAGLFSCM TFSWLSSLAR VAHKKGELSM EDVWSLSKHE SSDVNCRRLE 150
    RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPAFM 200
    VKHLLEYTQA TESNLQYSLL LVLGLLLTEI VRSWSLALTW ALNYRTGVRL 250
    RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG 300
    PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFASRLT AYFRRKCVAA 350
    TDERVQKMNE VLTYIKFIKM YAWVKAFSQS VQKIREEERR ILEKAGYFQS 400
    ITVGVAPIVV VIASVVTFSV HMTLGFDLTA AQAFTVVTVF NSMTFALKVT 450
    PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK NKPASPHIKI EMKNATLAWD 500
    SSHSSIQNSP KLTPKMKKDK RASRGKKEKV RQLQRTEHQA VLAEQKGHLL 550
    LDSDERPSPE EEEGKHIHLG HLRLQRTLHS IDLEIQEGKL VGICGSVGSG 600
    KTSLISAILG QMTLLEGSIA ISGTFAYVAQ QAWILNATLR DNILFGKEYD 650
    EERYNSVLNS CCLRPDLAIL PSSDLTEIGE RGANLSGGQR QRISLARALY 700
    SDRSIYILDD PLSALDAHVG NHIFNSAIRK HLKSKTVLFV THQLQYLVDC 750
    DEVIFMKEGC ITERGTHEEL MNLNGDYATI FNNLLLGETP PVEINSKKET 800
    SGSQKKSQDK GPKTGSVKKE KAVKPEEGQL VQLEEKGQGS VPWSVYGVYI 850
    QAAGGPLAFL VIMALFMLNV GSTAFSTWWL SYWIKQGSGN TTVTRGNETS 900
    VSDSMKDNPH MQYYASIYAL SMAVMLILKA IRGVVFVKGT LRASSRLHDE 950
    LFRRILRSPM KFFDTTPTGR ILNRFSKDMD EVDVRLPFQA EMFIQNVILV 1000
    FFCVGMIAGV FPWFLVAVGP LVILFSVLHI VSRVLIRELK RLDNITQSPF 1050
    LSHITSSIQG LATIHAYNKG QEFLHRYQEL LDDNQAPFFL FTCAMRWLAV 1100
    RLDLISIALI TTTGLMIVLM HGQIPPAYAG LAISYAVQLT GLFQFTVRLA 1150
    SETEARFTSV ERINHYIKTL SLEAPARIKN KAPSPDWPQE GEVTFENAEM 1200
    RYRENLPLVL KKVSFTIKPK EKIGIVGRTG SGKSSLGMAL FRLVELSGGC 1250
    IKIDGVRISD IGLADLRSKL SIIPQEPVLF SGTVRSNLDP FNQYTEDQIW 1300
    DALERTHMKE CIAQLPLKLE SEVMENGDNF SVGERQLLCI ARALLRHCKI 1350
    LILDEATAAM DTETDLLIQE TIREAFADCT MLTIAHRLHT VLGSDRIMVL 1400
    AQGQVVEFDT PSVLLSNDSS RFYAMFAAAE NKVAVKG 1437
    Length:1,437
    Mass (Da):160,660
    Last modified:December 1, 2000 - v2
    Checksum:i00558076B3BB4C00
    GO
    Isoform 2 (identifier: O15440-2) [UniParc]FASTAAdd to Basket

    Also known as: SV1

    The sequence of this isoform differs from the canonical sequence as follows:
         198-225: AFMVKHLLEYTQATESNLQYSLLLVLGL → PSFGDCSISAEVCGNRLHCTAILLSCFT
         226-1437: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:225
    Mass (Da):25,341
    Checksum:i771FBD2C32E08B8C
    GO
    Isoform 3 (identifier: O15440-3) [UniParc]FASTAAdd to Basket

    Also known as: SV2

    The sequence of this isoform differs from the canonical sequence as follows:
         198-212: AFMVKHLLEYTQATE → LAWCCQDLDLGGVSL
         213-225: Missing.
         226-1437: Missing.

    Note: Predominant isoform in retinal pigment epithelium, bladder, and stomach.

    Show »
    Length:212
    Mass (Da):23,988
    Checksum:iD562C6FBF01922D1
    GO
    Isoform 4 (identifier: O15440-4) [UniParc]FASTAAdd to Basket

    Also known as: SV3

    The sequence of this isoform differs from the canonical sequence as follows:
         198-208: AFMVKHLLEYT → NFQDGCILRSE
         209-225: Missing.
         226-1437: Missing.

    Show »
    Length:208
    Mass (Da):23,677
    Checksum:i3FF375FBCE128270
    GO
    Isoform 5 (identifier: O15440-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1033-1075: Missing.

    Show »
    Length:1,394
    Mass (Da):155,732
    Checksum:i5B11EC10EB9D07C9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti176 – 1761R → P in BAA76608. (PubMed:10721709)Curated
    Sequence conflicti400 – 4001S → G in AAD04169. (PubMed:9827529)Curated
    Sequence conflicti581 – 5811I → V in AAD37716. (PubMed:10438534)Curated
    Sequence conflicti1383 – 13831T → N in BAA76608. (PubMed:10721709)Curated
    Sequence conflicti1383 – 13831T → N in BAA22887. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei198 – 22528AFMVK…LVLGL → PSFGDCSISAEVCGNRLHCT AILLSCFT in isoform 2. 2 PublicationsVSP_043397Add
    BLAST
    Alternative sequencei198 – 21215AFMVK…TQATE → LAWCCQDLDLGGVSL in isoform 3. 1 PublicationVSP_043398Add
    BLAST
    Alternative sequencei198 – 20811AFMVKHLLEYT → NFQDGCILRSE in isoform 4. 1 PublicationVSP_043399Add
    BLAST
    Alternative sequencei209 – 22517Missing in isoform 4. 1 PublicationVSP_043400Add
    BLAST
    Alternative sequencei213 – 22513Missing in isoform 3. 1 PublicationVSP_043401Add
    BLAST
    Alternative sequencei226 – 14371212Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_043402Add
    BLAST
    Alternative sequencei1033 – 107543Missing in isoform 5. 1 PublicationVSP_055354Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104942 mRNA. Translation: AAD04169.1.
    AF146074 mRNA. Translation: AAD37716.1.
    AB019002 mRNA. Translation: BAA76608.1.
    U83661 mRNA. Translation: AAB71758.2.
    AY754874 mRNA. Translation: AAW82948.1.
    AY754875 mRNA. Translation: AAW82949.1.
    AY754876 mRNA. Translation: AAW82950.1.
    AY196484 mRNA. Translation: AAO49801.1.
    AC068644 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78307.1.
    CH471052 Genomic DNA. Translation: EAW78308.1.
    BC050744 mRNA. Translation: AAH50744.1.
    BC140771 mRNA. Translation: AAI40772.1.
    BC142719 mRNA. Translation: AAI42720.1.
    AB005659 mRNA. Translation: BAA22887.1.
    CCDSiCCDS33898.1. [O15440-4]
    CCDS43176.1. [O15440-1]
    PIRiJC5667.
    RefSeqiNP_001018881.1. NM_001023587.1. [O15440-4]
    NP_005679.2. NM_005688.2. [O15440-1]
    XP_005247115.1. XM_005247058.2. [O15440-1]
    XP_005247116.1. XM_005247059.2. [O15440-1]
    UniGeneiHs.368563.
    Hs.743953.

    Genome annotation databases

    EnsembliENST00000265586; ENSP00000265586; ENSG00000114770. [O15440-5]
    ENST00000334444; ENSP00000333926; ENSG00000114770. [O15440-1]
    ENST00000382494; ENSP00000371934; ENSG00000114770. [O15440-4]
    ENST00000392579; ENSP00000376358; ENSG00000114770. [O15440-2]
    ENST00000443376; ENSP00000416840; ENSG00000114770. [O15440-3]
    GeneIDi10057.
    KEGGihsa:10057.
    UCSCiuc003fmg.3. human. [O15440-1]
    uc003fmh.3. human. [O15440-4]
    uc010hxn.3. human. [O15440-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    ABCMdb

    Database for mutations in ABC proteins

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104942 mRNA. Translation: AAD04169.1 .
    AF146074 mRNA. Translation: AAD37716.1 .
    AB019002 mRNA. Translation: BAA76608.1 .
    U83661 mRNA. Translation: AAB71758.2 .
    AY754874 mRNA. Translation: AAW82948.1 .
    AY754875 mRNA. Translation: AAW82949.1 .
    AY754876 mRNA. Translation: AAW82950.1 .
    AY196484 mRNA. Translation: AAO49801.1 .
    AC068644 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78307.1 .
    CH471052 Genomic DNA. Translation: EAW78308.1 .
    BC050744 mRNA. Translation: AAH50744.1 .
    BC140771 mRNA. Translation: AAI40772.1 .
    BC142719 mRNA. Translation: AAI42720.1 .
    AB005659 mRNA. Translation: BAA22887.1 .
    CCDSi CCDS33898.1. [O15440-4 ]
    CCDS43176.1. [O15440-1 ]
    PIRi JC5667.
    RefSeqi NP_001018881.1. NM_001023587.1. [O15440-4 ]
    NP_005679.2. NM_005688.2. [O15440-1 ]
    XP_005247115.1. XM_005247058.2. [O15440-1 ]
    XP_005247116.1. XM_005247059.2. [O15440-1 ]
    UniGenei Hs.368563.
    Hs.743953.

    3D structure databases

    ProteinModelPortali O15440.
    SMRi O15440. Positions 532-843, 858-1433.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115368. 5 interactions.
    IntActi O15440. 5 interactions.
    STRINGi 9606.ENSP00000333926.

    Chemistry

    ChEMBLi CHEMBL2046258.
    DrugBanki DB00718. Adefovir Dipivoxil.
    DB00770. Alprostadil.
    DB01076. Atorvastatin.
    DB00515. Cisplatin.
    DB00917. Dinoprostone.
    DB00975. Dipyridamole.
    DB00544. Fluorouracil.
    DB00143. Glutathione.
    DB01033. Mercaptopurine.
    DB01032. Probenecid.
    DB01045. Rifampicin.
    DB00203. Sildenafil.
    DB01138. Sulfinpyrazone.
    DB00495. Zidovudine.

    Protein family/group databases

    TCDBi 3.A.1.208.15. the atp-binding cassette (abc) superfamily.

    PTM databases

    PhosphoSitei O15440.

    Proteomic databases

    MaxQBi O15440.
    PaxDbi O15440.
    PRIDEi O15440.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265586 ; ENSP00000265586 ; ENSG00000114770 . [O15440-5 ]
    ENST00000334444 ; ENSP00000333926 ; ENSG00000114770 . [O15440-1 ]
    ENST00000382494 ; ENSP00000371934 ; ENSG00000114770 . [O15440-4 ]
    ENST00000392579 ; ENSP00000376358 ; ENSG00000114770 . [O15440-2 ]
    ENST00000443376 ; ENSP00000416840 ; ENSG00000114770 . [O15440-3 ]
    GeneIDi 10057.
    KEGGi hsa:10057.
    UCSCi uc003fmg.3. human. [O15440-1 ]
    uc003fmh.3. human. [O15440-4 ]
    uc010hxn.3. human. [O15440-2 ]

    Organism-specific databases

    CTDi 10057.
    GeneCardsi GC03M183637.
    HGNCi HGNC:56. ABCC5.
    HPAi HPA052295.
    MIMi 605251. gene.
    neXtProti NX_O15440.
    PharmGKBi PA395.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1132.
    HOGENOMi HOG000116132.
    HOVERGENi HBG108314.
    InParanoidi O15440.
    KOi K05668.
    OMAi VIMALFM.
    OrthoDBi EOG7MWGW0.
    PhylomeDBi O15440.
    TreeFami TF105202.

    Enzyme and pathway databases

    Reactomei REACT_121301. Hyaluronan biosynthesis and export.
    REACT_15480. ABC-family proteins mediated transport.

    Miscellaneous databases

    ChiTaRSi ABCC5. human.
    GeneWikii ABCC5.
    GenomeRNAii 10057.
    NextBioi 37997.
    PROi O15440.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15440.
    Bgeei O15440.
    CleanExi HS_ABCC5.
    Genevestigatori O15440.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins."
      Belinsky M.G., Bain L.J., Balsara B.B., Testa J.R., Kruh G.D.
      J. Natl. Cancer Inst. 90:1735-1741(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells."
      McAleer M.A., Breen M.A., White N.L., Matthews N.
      J. Biol. Chem. 274:23541-23548(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts."
      Suzuki T., Sasaki H., Kuh H.J., Agui M., Tatsumi Y., Tanabe S., Terada M., Saijo N., Nishio K.
      Gene 242:167-173(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs."
      Wijnholds J., Mol C.A.A.M., van Deemter L., de Haas M., Scheffer G.L., Baas F., Beijnen J.H., Scheper R.J., Hatse S., De Clercq E., Balzarini J., Borst P.
      Proc. Natl. Acad. Sci. U.S.A. 97:7476-7481(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
      Tissue: Brain and Ovarian carcinoma.
    5. "Three novel ABCC5 splice variants in human retina and their role as regulators of ABCC5 gene expression."
      Stojic J., Stohr H., Weber B.H.
      BMC Mol. Biol. 8:42-42(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
      Tissue: Retina.
    6. Ito T., Kato R., Ishikawa T.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
      Tissue: Skeletal muscle.
    7. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Pancreas.
    10. "cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line."
      Suzuki T., Nishio K., Sasaki H., Kurokawa H., Saito-Ohara F., Ikeuch T., Tanabe S., Terada M., Saijo N.
      Biochem. Biophys. Res. Commun. 238:790-794(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 492-1437 (ISOFORM 1).
      Tissue: Bone marrow.
    11. "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines."
      Kool M., de Haas M., Scheffer G.L., Scheper R.J., van Eijk M.J., Juijn J.A., Baas F., Borst P.
      Cancer Res. 57:3537-3547(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1216-1437 (ISOFORM 1).
      Tissue: Brain.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509 AND THR-513, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiMRP5_HUMAN
    AccessioniPrimary (citable) accession number: O15440
    Secondary accession number(s): B9EIQ2
    , O14517, Q29ZA9, Q29ZB1, Q86UX3, Q86W30, Q9UN85, Q9UNP5, Q9UQC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3