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Protein

Multidrug resistance-associated protein 5

Gene

ABCC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a multispecific organic anion pump which can transport nucleotide analogs.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi595 – 602ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1227 – 1234ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • hyaluronan biosynthetic process Source: Reactome
  • transmembrane transport Source: Reactome
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114770-MONOMER.
ReactomeiR-HSA-2142850. Hyaluronan biosynthesis and export.
R-HSA-382556. ABC-family proteins mediated transport.

Protein family/group databases

TCDBi3.A.1.208.15. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 5
Alternative name(s):
ATP-binding cassette sub-family C member 5
Multi-specific organic anion transporter C
Short name:
MOAT-C
SMRP
pABC11
Gene namesi
Name:ABCC5
Synonyms:MRP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:56. ABCC5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei179 – 199HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei219 – 239HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei296 – 316HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei317 – 337HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei400 – 420HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei434 – 454HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei608 – 628HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei848 – 868HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei917 – 937HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei997 – 1017HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1018 – 1038HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1104 – 1124HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1127 – 1147HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: MGI
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10057.
OpenTargetsiENSG00000114770.
PharmGKBiPA395.

Chemistry databases

ChEMBLiCHEMBL2046258.
DrugBankiDB00718. Adefovir Dipivoxil.
DB00770. Alprostadil.
DB01076. Atorvastatin.
DB00515. Cisplatin.
DB00917. Dinoprostone.
DB00975. Dipyridamole.
DB00544. Fluorouracil.
DB00143. Glutathione.
DB01033. Mercaptopurine.
DB01032. Probenecid.
DB01045. Rifampicin.
DB00203. Sildenafil.
DB01138. Sulfinpyrazone.
DB00495. Zidovudine.
GuidetoPHARMACOLOGYi783.

Polymorphism and mutation databases

BioMutaiABCC5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933631 – 1437Multidrug resistance-associated protein 5Add BLAST1437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Glycosylationi494N-linked (GlcNAc...)Sequence analysis1
Modified residuei505PhosphoserineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei513PhosphothreonineCombined sources1
Glycosylationi636N-linked (GlcNAc...)Sequence analysis1
Glycosylationi684N-linked (GlcNAc...)Sequence analysis1
Glycosylationi890N-linked (GlcNAc...)Sequence analysis1
Glycosylationi897N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1044N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1329N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1417N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO15440.
MaxQBiO15440.
PaxDbiO15440.
PeptideAtlasiO15440.
PRIDEiO15440.

PTM databases

iPTMnetiO15440.
PhosphoSitePlusiO15440.

Expressioni

Tissue specificityi

All isoforms are equally expressed in retina.1 Publication

Gene expression databases

BgeeiENSG00000114770.
CleanExiHS_ABCC5.
ExpressionAtlasiO15440. baseline and differential.
GenevisibleiO15440. HS.

Organism-specific databases

HPAiHPA044067.
HPA052295.

Interactioni

Protein-protein interaction databases

BioGridi115368. 12 interactors.
IntActiO15440. 8 interactors.
STRINGi9606.ENSP00000333926.

Chemistry databases

BindingDBiO15440.

Structurei

3D structure databases

ProteinModelPortaliO15440.
SMRiO15440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 459ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST281
Domaini562 – 783ABC transporter 1PROSITE-ProRule annotationAdd BLAST222
Domaini859 – 1155ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST297
Domaini1193 – 1427ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133722.
HOGENOMiHOG000116132.
HOVERGENiHBG108314.
InParanoidiO15440.
KOiK05668.
OMAiKHIHLGS.
OrthoDBiEOG091G01TC.
PhylomeDBiO15440.
TreeFamiTF105202.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030238. ABCC5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF196. PTHR24223:SF196. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15440-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL
60 70 80 90 100
ETAARAEGLS LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP
110 120 130 140 150
VDNAGLFSCM TFSWLSSLAR VAHKKGELSM EDVWSLSKHE SSDVNCRRLE
160 170 180 190 200
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPAFM
210 220 230 240 250
VKHLLEYTQA TESNLQYSLL LVLGLLLTEI VRSWSLALTW ALNYRTGVRL
260 270 280 290 300
RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG
310 320 330 340 350
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFASRLT AYFRRKCVAA
360 370 380 390 400
TDERVQKMNE VLTYIKFIKM YAWVKAFSQS VQKIREEERR ILEKAGYFQS
410 420 430 440 450
ITVGVAPIVV VIASVVTFSV HMTLGFDLTA AQAFTVVTVF NSMTFALKVT
460 470 480 490 500
PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK NKPASPHIKI EMKNATLAWD
510 520 530 540 550
SSHSSIQNSP KLTPKMKKDK RASRGKKEKV RQLQRTEHQA VLAEQKGHLL
560 570 580 590 600
LDSDERPSPE EEEGKHIHLG HLRLQRTLHS IDLEIQEGKL VGICGSVGSG
610 620 630 640 650
KTSLISAILG QMTLLEGSIA ISGTFAYVAQ QAWILNATLR DNILFGKEYD
660 670 680 690 700
EERYNSVLNS CCLRPDLAIL PSSDLTEIGE RGANLSGGQR QRISLARALY
710 720 730 740 750
SDRSIYILDD PLSALDAHVG NHIFNSAIRK HLKSKTVLFV THQLQYLVDC
760 770 780 790 800
DEVIFMKEGC ITERGTHEEL MNLNGDYATI FNNLLLGETP PVEINSKKET
810 820 830 840 850
SGSQKKSQDK GPKTGSVKKE KAVKPEEGQL VQLEEKGQGS VPWSVYGVYI
860 870 880 890 900
QAAGGPLAFL VIMALFMLNV GSTAFSTWWL SYWIKQGSGN TTVTRGNETS
910 920 930 940 950
VSDSMKDNPH MQYYASIYAL SMAVMLILKA IRGVVFVKGT LRASSRLHDE
960 970 980 990 1000
LFRRILRSPM KFFDTTPTGR ILNRFSKDMD EVDVRLPFQA EMFIQNVILV
1010 1020 1030 1040 1050
FFCVGMIAGV FPWFLVAVGP LVILFSVLHI VSRVLIRELK RLDNITQSPF
1060 1070 1080 1090 1100
LSHITSSIQG LATIHAYNKG QEFLHRYQEL LDDNQAPFFL FTCAMRWLAV
1110 1120 1130 1140 1150
RLDLISIALI TTTGLMIVLM HGQIPPAYAG LAISYAVQLT GLFQFTVRLA
1160 1170 1180 1190 1200
SETEARFTSV ERINHYIKTL SLEAPARIKN KAPSPDWPQE GEVTFENAEM
1210 1220 1230 1240 1250
RYRENLPLVL KKVSFTIKPK EKIGIVGRTG SGKSSLGMAL FRLVELSGGC
1260 1270 1280 1290 1300
IKIDGVRISD IGLADLRSKL SIIPQEPVLF SGTVRSNLDP FNQYTEDQIW
1310 1320 1330 1340 1350
DALERTHMKE CIAQLPLKLE SEVMENGDNF SVGERQLLCI ARALLRHCKI
1360 1370 1380 1390 1400
LILDEATAAM DTETDLLIQE TIREAFADCT MLTIAHRLHT VLGSDRIMVL
1410 1420 1430
AQGQVVEFDT PSVLLSNDSS RFYAMFAAAE NKVAVKG
Length:1,437
Mass (Da):160,660
Last modified:December 1, 2000 - v2
Checksum:i00558076B3BB4C00
GO
Isoform 2 (identifier: O15440-2) [UniParc]FASTAAdd to basket
Also known as: SV1

The sequence of this isoform differs from the canonical sequence as follows:
     198-225: AFMVKHLLEYTQATESNLQYSLLLVLGL → PSFGDCSISAEVCGNRLHCTAILLSCFT
     226-1437: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:225
Mass (Da):25,341
Checksum:i771FBD2C32E08B8C
GO
Isoform 3 (identifier: O15440-3) [UniParc]FASTAAdd to basket
Also known as: SV2

The sequence of this isoform differs from the canonical sequence as follows:
     198-212: AFMVKHLLEYTQATE → LAWCCQDLDLGGVSL
     213-225: Missing.
     226-1437: Missing.

Note: Predominant isoform in retinal pigment epithelium, bladder, and stomach.
Show »
Length:212
Mass (Da):23,988
Checksum:iD562C6FBF01922D1
GO
Isoform 4 (identifier: O15440-4) [UniParc]FASTAAdd to basket
Also known as: SV3

The sequence of this isoform differs from the canonical sequence as follows:
     198-208: AFMVKHLLEYT → NFQDGCILRSE
     209-225: Missing.
     226-1437: Missing.

Show »
Length:208
Mass (Da):23,677
Checksum:i3FF375FBCE128270
GO
Isoform 5 (identifier: O15440-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1033-1075: Missing.

Show »
Length:1,394
Mass (Da):155,732
Checksum:i5B11EC10EB9D07C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176R → P in BAA76608 (PubMed:10721709).Curated1
Sequence conflicti400S → G in AAD04169 (PubMed:9827529).Curated1
Sequence conflicti581I → V in AAD37716 (PubMed:10438534).Curated1
Sequence conflicti1383T → N in BAA76608 (PubMed:10721709).Curated1
Sequence conflicti1383T → N in BAA22887 (Ref. 8) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043397198 – 225AFMVK…LVLGL → PSFGDCSISAEVCGNRLHCT AILLSCFT in isoform 2. 2 PublicationsAdd BLAST28
Alternative sequenceiVSP_043398198 – 212AFMVK…TQATE → LAWCCQDLDLGGVSL in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_043399198 – 208AFMVKHLLEYT → NFQDGCILRSE in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_043400209 – 225Missing in isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_043401213 – 225Missing in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_043402226 – 1437Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST1212
Alternative sequenceiVSP_0553541033 – 1075Missing in isoform 5. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104942 mRNA. Translation: AAD04169.1.
AF146074 mRNA. Translation: AAD37716.1.
AB019002 mRNA. Translation: BAA76608.1.
U83661 mRNA. Translation: AAB71758.2.
AY754874 mRNA. Translation: AAW82948.1.
AY754875 mRNA. Translation: AAW82949.1.
AY754876 mRNA. Translation: AAW82950.1.
AY196484 mRNA. Translation: AAO49801.1.
AC068644 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78307.1.
CH471052 Genomic DNA. Translation: EAW78308.1.
BC050744 mRNA. Translation: AAH50744.1.
BC140771 mRNA. Translation: AAI40772.1.
BC142719 mRNA. Translation: AAI42720.1.
AB005659 mRNA. Translation: BAA22887.1.
CCDSiCCDS33898.1. [O15440-4]
CCDS43176.1. [O15440-1]
PIRiJC5667.
RefSeqiNP_001018881.1. NM_001023587.2. [O15440-4]
NP_001306961.1. NM_001320032.1.
NP_005679.2. NM_005688.3. [O15440-1]
XP_005247115.1. XM_005247058.4. [O15440-1]
XP_005247116.1. XM_005247059.4. [O15440-1]
XP_011510616.1. XM_011512314.1. [O15440-1]
XP_016860982.1. XM_017005493.1. [O15440-4]
XP_016860983.1. XM_017005494.1. [O15440-4]
UniGeneiHs.368563.
Hs.732645.
Hs.743953.

Genome annotation databases

EnsembliENST00000265586; ENSP00000265586; ENSG00000114770. [O15440-5]
ENST00000334444; ENSP00000333926; ENSG00000114770. [O15440-1]
ENST00000382494; ENSP00000371934; ENSG00000114770. [O15440-4]
ENST00000392579; ENSP00000376358; ENSG00000114770. [O15440-2]
ENST00000443376; ENSP00000416840; ENSG00000114770. [O15440-3]
GeneIDi10057.
KEGGihsa:10057.
UCSCiuc003fmg.4. human. [O15440-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104942 mRNA. Translation: AAD04169.1.
AF146074 mRNA. Translation: AAD37716.1.
AB019002 mRNA. Translation: BAA76608.1.
U83661 mRNA. Translation: AAB71758.2.
AY754874 mRNA. Translation: AAW82948.1.
AY754875 mRNA. Translation: AAW82949.1.
AY754876 mRNA. Translation: AAW82950.1.
AY196484 mRNA. Translation: AAO49801.1.
AC068644 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78307.1.
CH471052 Genomic DNA. Translation: EAW78308.1.
BC050744 mRNA. Translation: AAH50744.1.
BC140771 mRNA. Translation: AAI40772.1.
BC142719 mRNA. Translation: AAI42720.1.
AB005659 mRNA. Translation: BAA22887.1.
CCDSiCCDS33898.1. [O15440-4]
CCDS43176.1. [O15440-1]
PIRiJC5667.
RefSeqiNP_001018881.1. NM_001023587.2. [O15440-4]
NP_001306961.1. NM_001320032.1.
NP_005679.2. NM_005688.3. [O15440-1]
XP_005247115.1. XM_005247058.4. [O15440-1]
XP_005247116.1. XM_005247059.4. [O15440-1]
XP_011510616.1. XM_011512314.1. [O15440-1]
XP_016860982.1. XM_017005493.1. [O15440-4]
XP_016860983.1. XM_017005494.1. [O15440-4]
UniGeneiHs.368563.
Hs.732645.
Hs.743953.

3D structure databases

ProteinModelPortaliO15440.
SMRiO15440.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115368. 12 interactors.
IntActiO15440. 8 interactors.
STRINGi9606.ENSP00000333926.

Chemistry databases

BindingDBiO15440.
ChEMBLiCHEMBL2046258.
DrugBankiDB00718. Adefovir Dipivoxil.
DB00770. Alprostadil.
DB01076. Atorvastatin.
DB00515. Cisplatin.
DB00917. Dinoprostone.
DB00975. Dipyridamole.
DB00544. Fluorouracil.
DB00143. Glutathione.
DB01033. Mercaptopurine.
DB01032. Probenecid.
DB01045. Rifampicin.
DB00203. Sildenafil.
DB01138. Sulfinpyrazone.
DB00495. Zidovudine.
GuidetoPHARMACOLOGYi783.

Protein family/group databases

TCDBi3.A.1.208.15. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiO15440.
PhosphoSitePlusiO15440.

Polymorphism and mutation databases

BioMutaiABCC5.

Proteomic databases

EPDiO15440.
MaxQBiO15440.
PaxDbiO15440.
PeptideAtlasiO15440.
PRIDEiO15440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265586; ENSP00000265586; ENSG00000114770. [O15440-5]
ENST00000334444; ENSP00000333926; ENSG00000114770. [O15440-1]
ENST00000382494; ENSP00000371934; ENSG00000114770. [O15440-4]
ENST00000392579; ENSP00000376358; ENSG00000114770. [O15440-2]
ENST00000443376; ENSP00000416840; ENSG00000114770. [O15440-3]
GeneIDi10057.
KEGGihsa:10057.
UCSCiuc003fmg.4. human. [O15440-1]

Organism-specific databases

CTDi10057.
DisGeNETi10057.
GeneCardsiABCC5.
HGNCiHGNC:56. ABCC5.
HPAiHPA044067.
HPA052295.
MIMi605251. gene.
neXtProtiNX_O15440.
OpenTargetsiENSG00000114770.
PharmGKBiPA395.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133722.
HOGENOMiHOG000116132.
HOVERGENiHBG108314.
InParanoidiO15440.
KOiK05668.
OMAiKHIHLGS.
OrthoDBiEOG091G01TC.
PhylomeDBiO15440.
TreeFamiTF105202.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114770-MONOMER.
ReactomeiR-HSA-2142850. Hyaluronan biosynthesis and export.
R-HSA-382556. ABC-family proteins mediated transport.

Miscellaneous databases

ChiTaRSiABCC5. human.
GeneWikiiABCC5.
GenomeRNAii10057.
PROiO15440.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114770.
CleanExiHS_ABCC5.
ExpressionAtlasiO15440. baseline and differential.
GenevisibleiO15440. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030238. ABCC5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF196. PTHR24223:SF196. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP5_HUMAN
AccessioniPrimary (citable) accession number: O15440
Secondary accession number(s): B9EIQ2
, O14517, Q29ZA9, Q29ZB1, Q86UX3, Q86W30, Q9UN85, Q9UNP5, Q9UQC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.