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O15439

- MRP4_HUMAN

UniProt

O15439 - MRP4_HUMAN

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Protein

Multidrug resistance-associated protein 4

Gene
ABCC4, MRP4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be an organic anion pump relevant to cellular detoxification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi445 – 4528ATP 1 Reviewed prediction
Nucleotide bindingi1075 – 10828ATP 2 Reviewed prediction

GO - Molecular functioni

  1. 15-hydroxyprostaglandin dehydrogenase (NAD+) activity Source: UniProtKB
  2. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  3. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. oxidation-reduction process Source: GOC
  3. platelet activation Source: Reactome
  4. platelet degranulation Source: Reactome
  5. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_15480. ABC-family proteins mediated transport.

Protein family/group databases

TCDBi3.A.1.208.7. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 4
Alternative name(s):
ATP-binding cassette sub-family C member 4
MRP/cMOAT-related ABC transporter
Multi-specific organic anion transporter B
Short name:
MOAT-B
Gene namesi
Name:ABCC4
Synonyms:MRP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:55. ABCC4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei93 – 11321Helical; Reviewed predictionAdd
BLAST
Transmembranei136 – 15621Helical; Reviewed predictionAdd
BLAST
Transmembranei207 – 22721Helical; Reviewed predictionAdd
BLAST
Transmembranei228 – 24821Helical; Reviewed predictionAdd
BLAST
Transmembranei328 – 34821Helical; Reviewed predictionAdd
BLAST
Transmembranei351 – 37121Helical; Reviewed predictionAdd
BLAST
Transmembranei440 – 46021Helical; Reviewed predictionAdd
BLAST
Transmembranei710 – 73021Helical; Reviewed predictionAdd
BLAST
Transmembranei771 – 79121Helical; Reviewed predictionAdd
BLAST
Transmembranei836 – 85621Helical; Reviewed predictionAdd
BLAST
Transmembranei858 – 87821Helical; Reviewed predictionAdd
BLAST
Transmembranei954 – 97421Helical; Reviewed predictionAdd
BLAST
Transmembranei977 – 99721Helical; Reviewed predictionAdd
BLAST
Transmembranei1038 – 105821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
  3. plasma membrane Source: MGI
  4. platelet dense granule membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA397.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13251325Multidrug resistance-associated protein 4PRO_0000093362Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei646 – 6461Phosphothreonine3 Publications
Glycosylationi651 – 6511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi690 – 6901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi746 – 7461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi754 – 7541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi792 – 7921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1176 – 11761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1309 – 13091N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO15439.
PaxDbiO15439.
PRIDEiO15439.

PTM databases

PhosphoSiteiO15439.

Expressioni

Tissue specificityi

Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

Gene expression databases

ArrayExpressiO15439.
BgeeiO15439.
CleanExiHS_ABCC4.
GenevestigatoriO15439.

Organism-specific databases

HPAiCAB002751.
HPA002476.

Interactioni

Subunit structurei

Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain).1 Publication

Protein-protein interaction databases

BioGridi115551. 9 interactions.
IntActiO15439. 1 interaction.
STRINGi9606.ENSP00000366084.

Structurei

3D structure databases

ProteinModelPortaliO15439.
SMRiO15439. Positions 92-650, 797-1272.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini92 – 377286ABC transmembrane type-1 1Add
BLAST
Domaini410 – 633224ABC transporter 1Add
BLAST
Domaini714 – 1005292ABC transmembrane type-1 2Add
BLAST
Domaini1041 – 1274234ABC transporter 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1322 – 13254PDZ-binding

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
HOVERGENiHBG108314.
InParanoidiO15439.
KOiK05673.
OMAiCAMFVII.
OrthoDBiEOG7MWGW0.
PhylomeDBiO15439.
TreeFamiTF105202.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O15439-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLPVYQEVKP NPLQDANLCS RVFFWWLNPL FKIGHKRRLE EDDMYSVLPE     50
DRSQHLGEEL QGFWDKEVLR AENDAQKPSL TRAIIKCYWK SYLVLGIFTL 100
IEESAKVIQP IFLGKIINYF ENYDPMDSVA LNTAYAYATV LTFCTLILAI 150
LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR LSNMAMGKTT TGQIVNLLSN 200
DVNKFDQVTV FLHFLWAGPL QAIAVTALLW MEIGISCLAG MAVLIILLPL 250
QSCFGKLFSS LRSKTATFTD ARIRTMNEVI TGIRIIKMYA WEKSFSNLIT 300
NLRKKEISKI LRSSCLRGMN LASFFSASKI IVFVTFTTYV LLGSVITASR 350
VFVAVTLYGA VRLTVTLFFP SAIERVSEAI VSIRRIQTFL LLDEISQRNR 400
QLPSDGKKMV HVQDFTAFWD KASETPTLQG LSFTVRPGEL LAVVGPVGAG 450
KSSLLSAVLG ELAPSHGLVS VHGRIAYVSQ QPWVFSGTLR SNILFGKKYE 500
KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGTTLSGGQK ARVNLARAVY 550
QDADIYLLDD PLSAVDAEVS RHLFELCICQ ILHEKITILV THQLQYLKAA 600
SQILILKDGK MVQKGTYTEF LKSGIDFGSL LKKDNEESEQ PPVPGTPTLR 650
NRTFSESSVW SQQSSRPSLK DGALESQDTE NVPVTLSEEN RSEGKVGFQA 700
YKNYFRAGAH WIVFIFLILL NTAAQVAYVL QDWWLSYWAN KQSMLNVTVN 750
GGGNVTEKLD LNWYLGIYSG LTVATVLFGI ARSLLVFYVL VNSSQTLHNK 800
MFESILKAPV LFFDRNPIGR ILNRFSKDIG HLDDLLPLTF LDFIQTLLQV 850
VGVVSVAVAV IPWIAIPLVP LGIIFIFLRR YFLETSRDVK RLESTTRSPV 900
FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV 950
RLDAICAMFV IIVAFGSLIL AKTLDAGQVG LALSYALTLM GMFQWCVRQS 1000
AEVENMMISV ERVIEYTDLE KEAPWEYQKR PPPAWPHEGV IIFDNVNFMY 1050
SPGGPLVLKH LTALIKSQEK VGIVGRTGAG KSSLISALFR LSEPEGKIWI 1100
DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE HTDEELWNAL 1150
QEVQLKETIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILRKNQILII 1200
DEATANVDPR TDELIQKKIR EKFAHCTVLT IAHRLNTIID SDKIMVLDSG 1250
RLKEYDEPYV LLQNKESLFY KMVQQLGKAE AAALTETAKQ VYFKRNYPHI 1300
GHTDHMVTNT SNGQPSTLTI FETAL 1325
Length:1,325
Mass (Da):149,527
Last modified:September 23, 2008 - v3
Checksum:iBF2D53136B78C0BA
GO
Isoform 2 (identifier: O15439-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     679-725: Missing.

Show »
Length:1,278
Mass (Da):144,201
Checksum:i1B51AE7536A136E8
GO
Isoform 3 (identifier: O15439-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     846-859: TLLQVVGVVSVAVA → RWDLAVLSWLVSNS
     860-1325: Missing.

Note: No experimental confirmation available.

Show »
Length:859
Mass (Da):96,841
Checksum:iA254809A2F5CE133
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181L → I.2 Publications
Corresponds to variant rs11568681 [ dbSNP | Ensembl ].
VAR_046445
Natural varianti78 – 781P → A.
Corresponds to variant rs11568689 [ dbSNP | Ensembl ].
VAR_029121
Natural varianti171 – 1711C → G.
Corresponds to variant rs4148460 [ dbSNP | Ensembl ].
VAR_046446
Natural varianti184 – 1841M → T.
Corresponds to variant rs45454092 [ dbSNP | Ensembl ].
VAR_020241
Natural varianti187 – 1871G → W Transport properties comparable to wild-type. 1 Publication
Corresponds to variant rs11568658 [ dbSNP | Ensembl ].
VAR_020242
Natural varianti293 – 2931K → E.
Corresponds to variant rs11568684 [ dbSNP | Ensembl ].
VAR_046447
Natural varianti304 – 3041K → N Transport properties comparable to wild-type. 1 Publication
Corresponds to variant rs2274407 [ dbSNP | Ensembl ].
VAR_022072
Natural varianti356 – 3561T → M.
Corresponds to variant rs11568701 [ dbSNP | Ensembl ].
VAR_046448
Natural varianti403 – 4031P → L.
Corresponds to variant rs11568705 [ dbSNP | Ensembl ].
VAR_029122
Natural varianti487 – 4871G → E Transport properties comparable to wild-type. 1 Publication
Corresponds to variant rs11568668 [ dbSNP | Ensembl ].
VAR_029123
Natural varianti498 – 4981K → E.
Corresponds to variant rs11568669 [ dbSNP | Ensembl ].
VAR_020243
Natural varianti556 – 5561Y → C 40% reduced expression level compared to wild-type; higher transport of 9-(2-phosphonyl-methoxyethyl) adenine than wild-type. 1 Publication
VAR_045684
Natural varianti625 – 6251I → M.
Corresponds to variant rs11568699 [ dbSNP | Ensembl ].
VAR_029124
Natural varianti667 – 6671P → L.
Corresponds to variant rs11568697 [ dbSNP | Ensembl ].
VAR_029125
Natural varianti744 – 7441M → V.
Corresponds to variant rs9282570 [ dbSNP | Ensembl ].
VAR_020244
Natural varianti757 – 7571E → K 10% reduced expression level compared to wild-type; transport properties comparable to wild-type. 2 Publications
Corresponds to variant rs3765534 [ dbSNP | Ensembl ].
VAR_022073
Natural varianti776 – 7761V → I 20% reduced expression level compared to wild-type; significant lower activity in 6-mercaptopurine transport than wild-type. 1 Publication
VAR_045685
Natural varianti820 – 8201R → I Transport properties comparable to wild-type. 1 Publication
Corresponds to variant rs11568659 [ dbSNP | Ensembl ].
VAR_045686
Natural varianti854 – 8541V → F Transport properties comparable to wild-type. 1 Publication
Corresponds to variant rs11568694 [ dbSNP | Ensembl ].
VAR_045687
Natural varianti860 – 8601V → M.
Corresponds to variant rs45477596 [ dbSNP | Ensembl ].
VAR_020245
Natural varianti866 – 8661I → V Transport properties comparable to wild-type. 1 Publication
Corresponds to variant rs139970608 [ dbSNP | Ensembl ].
VAR_045688
Natural varianti900 – 9001V → L.
Corresponds to variant rs45504892 [ dbSNP | Ensembl ].
VAR_020246
Natural varianti1142 – 11421T → M 10% reduced expression level compared to wild-type; transport properties comparable to wild-type. 1 Publication
Corresponds to variant rs11568644 [ dbSNP | Ensembl ].
VAR_029126

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei679 – 72547Missing in isoform 2. VSP_035426Add
BLAST
Alternative sequencei846 – 85914TLLQV…SVAVA → RWDLAVLSWLVSNS in isoform 3. VSP_043283Add
BLAST
Alternative sequencei860 – 1325466Missing in isoform 3. VSP_043284Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti703 – 7031N → S in AAL88745. 1 Publication
Sequence conflicti757 – 7571E → G in AAL88745. 1 Publication
Sequence conflicti893 – 8931E → G in AAL88745. 1 Publication
Sequence conflicti1139 – 11391N → K in AAC27076. 1 Publication
Sequence conflicti1302 – 13021H → D in AAB71757. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071202 mRNA. Translation: AAC27076.1.
AY081219 mRNA. Translation: AAL88745.1.
AY207008 mRNA. Translation: AAO37649.1.
AF541977 mRNA. Translation: AAN17334.1.
AL157818, AL139381, AL356257 Genomic DNA. Translation: CAC36037.2.
AL139381, AL157818, AL356257 Genomic DNA. Translation: CAI16589.1.
AL356257, AL139381, AL157818 Genomic DNA. Translation: CAI16722.1.
AL359750 Genomic DNA. No translation available.
CH471085 Genomic DNA. Translation: EAX08951.1.
CH471085 Genomic DNA. Translation: EAX08950.1.
BC041560 mRNA. Translation: AAH41560.1.
U83660 mRNA. Translation: AAB71757.1.
CCDSiCCDS45061.1. [O15439-3]
CCDS9474.1. [O15439-1]
RefSeqiNP_001098985.1. NM_001105515.1. [O15439-3]
NP_005836.2. NM_005845.3. [O15439-1]
UniGeneiHs.508423.

Genome annotation databases

EnsembliENST00000376887; ENSP00000366084; ENSG00000125257. [O15439-1]
ENST00000412704; ENSP00000388657; ENSG00000125257. [O15439-2]
ENST00000431522; ENSP00000398562; ENSG00000125257. [O15439-3]
GeneIDi10257.
KEGGihsa:10257.
UCSCiuc001vmd.4. human. [O15439-1]
uc001vme.2. human. [O15439-3]
uc010afk.3. human. [O15439-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071202 mRNA. Translation: AAC27076.1 .
AY081219 mRNA. Translation: AAL88745.1 .
AY207008 mRNA. Translation: AAO37649.1 .
AF541977 mRNA. Translation: AAN17334.1 .
AL157818 , AL139381 , AL356257 Genomic DNA. Translation: CAC36037.2 .
AL139381 , AL157818 , AL356257 Genomic DNA. Translation: CAI16589.1 .
AL356257 , AL139381 , AL157818 Genomic DNA. Translation: CAI16722.1 .
AL359750 Genomic DNA. No translation available.
CH471085 Genomic DNA. Translation: EAX08951.1 .
CH471085 Genomic DNA. Translation: EAX08950.1 .
BC041560 mRNA. Translation: AAH41560.1 .
U83660 mRNA. Translation: AAB71757.1 .
CCDSi CCDS45061.1. [O15439-3 ]
CCDS9474.1. [O15439-1 ]
RefSeqi NP_001098985.1. NM_001105515.1. [O15439-3 ]
NP_005836.2. NM_005845.3. [O15439-1 ]
UniGenei Hs.508423.

3D structure databases

ProteinModelPortali O15439.
SMRi O15439. Positions 92-650, 797-1272.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115551. 9 interactions.
IntActi O15439. 1 interaction.
STRINGi 9606.ENSP00000366084.

Chemistry

ChEMBLi CHEMBL1743128.
DrugBanki DB01327. Cefazolin.

Protein family/group databases

TCDBi 3.A.1.208.7. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSitei O15439.

Proteomic databases

MaxQBi O15439.
PaxDbi O15439.
PRIDEi O15439.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376887 ; ENSP00000366084 ; ENSG00000125257 . [O15439-1 ]
ENST00000412704 ; ENSP00000388657 ; ENSG00000125257 . [O15439-2 ]
ENST00000431522 ; ENSP00000398562 ; ENSG00000125257 . [O15439-3 ]
GeneIDi 10257.
KEGGi hsa:10257.
UCSCi uc001vmd.4. human. [O15439-1 ]
uc001vme.2. human. [O15439-3 ]
uc010afk.3. human. [O15439-2 ]

Organism-specific databases

CTDi 10257.
GeneCardsi GC13M095672.
HGNCi HGNC:55. ABCC4.
HPAi CAB002751.
HPA002476.
MIMi 605250. gene.
neXtProti NX_O15439.
PharmGKBi PA397.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1132.
HOVERGENi HBG108314.
InParanoidi O15439.
KOi K05673.
OMAi CAMFVII.
OrthoDBi EOG7MWGW0.
PhylomeDBi O15439.
TreeFami TF105202.

Enzyme and pathway databases

Reactomei REACT_15480. ABC-family proteins mediated transport.

Miscellaneous databases

GeneWikii ABCC4.
GenomeRNAii 10257.
NextBioi 38868.
PROi O15439.
SOURCEi Search...

Gene expression databases

ArrayExpressi O15439.
Bgeei O15439.
CleanExi HS_ABCC4.
Genevestigatori O15439.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter."
    Lee K., Belinsky M.G., Bell D.W., Testa J.R., Kruh G.D.
    Cancer Res. 58:2741-2747(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-18.
  2. "Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing."
    Adachi M., Sampath J., Lan L.B., Sun D., Hargrove P., Flatley R., Tatum A., Edwards M.Z., Wezeman M., Matherly L., Drake R., Schuetz J.
    J. Biol. Chem. 277:38998-39004(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-18.
  3. Kato R., Ishikawa T.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney.
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  7. "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines."
    Kool M., de Haas M., Scheffer G.L., Scheper R.J., van Eijk M.J., Juijn J.A., Baas F., Borst P.
    Cancer Res. 57:3537-3547(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1155-1316 (ISOFORMS 1/2).
    Tissue: Brain.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4."
    Hayashi H., Naoi S., Nakagawa T., Nishikawa T., Fukuda H., Imajoh-Ohmi S., Kondo A., Kubo K., Yabuki T., Hattori A., Hirouchi M., Sugiyama Y.
    J. Biol. Chem. 287:15054-15065(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNX27.
  14. "6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4."
    Janke D., Mehralivand S., Strand D., Goedtel-Armbrust U., Habermeier A., Gradhand U., Fischer C., Toliat M.R., Fritz P., Zanger U.M., Schwab M., Fromm M.F., Nuernberg P., Wojnowski L., Closs E.I., Lang T.
    Hum. Mutat. 29:659-669(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CYS-556; ILE-776; ILE-820; PHE-854 AND VAL-866, CHARACTERIZATION OF VARIANTS TRP-187; ASN-304; GLU-487; CYS-556; LYS-757; ILE-776; ILE-820; PHE-854; VAL-866 AND MET-1142.
  15. Cited for: VARIANT LYS-757.

Entry informationi

Entry nameiMRP4_HUMAN
AccessioniPrimary (citable) accession number: O15439
Secondary accession number(s): A9Z1Z7
, Q8IVZ4, Q8IZN6, Q8NEW8, Q9Y6J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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