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Protein

Multidrug resistance-associated protein 4

Gene

ABCC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be an organic anion pump relevant to cellular detoxification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi445 – 452ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1075 – 1082ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125257-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-382556. ABC-family proteins mediated transport.

Protein family/group databases

TCDBi3.A.1.208.7. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 4
Alternative name(s):
ATP-binding cassette sub-family C member 4
MRP/cMOAT-related ABC transporter
Multi-specific organic anion transporter B
Short name:
MOAT-B
Gene namesi
Name:ABCC4
Synonyms:MRP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:55. ABCC4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei93 – 113HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei136 – 156HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei207 – 227HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei228 – 248HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei328 – 348HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei351 – 371HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei440 – 460HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei710 – 730HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei771 – 791HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei836 – 856HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei858 – 878HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei954 – 974HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei977 – 997HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1038 – 1058HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • basolateral plasma membrane Source: CACAO
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • plasma membrane Source: MGI
  • platelet dense granule membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10257.
OpenTargetsiENSG00000125257.
PharmGKBiPA397.

Chemistry databases

ChEMBLiCHEMBL1743128.
DrugBankiDB00718. Adefovir Dipivoxil.
DB00770. Alprostadil.
DB01076. Atorvastatin.
DB01327. Cefazolin.
DB00482. Celecoxib.
DB02659. Cholic Acid.
DB00286. Conjugated Estrogens.
DB00586. Diclofenac.
DB00917. Dinoprostone.
DB00975. Dipyridamole.
DB00544. Fluorouracil.
DB00712. Flurbiprofen.
DB00158. Folic Acid.
DB08884. Gadoxetate.
DB00143. Glutathione.
DB01050. Ibuprofen.
DB00328. Indomethacin.
DB01009. Ketoprofen.
DB00709. Lamivudine.
DB00650. Leucovorin.
DB00814. Meloxicam.
DB01033. Mercaptopurine.
DB00563. Methotrexate.
DB00731. Nateglinide.
DB00198. Oseltamivir.
DB01032. Probenecid.
DB01098. Rosuvastatin.
DB00203. Sildenafil.
DB00398. Sorafenib.
DB01138. Sulfinpyrazone.
DB01268. Sunitinib.
DB00300. Tenofovir.
DB00352. Tioguanine.
DB01586. Ursodeoxycholic acid.
DB00661. Verapamil.
DB00495. Zidovudine.
GuidetoPHARMACOLOGYi782.

Polymorphism and mutation databases

BioMutaiABCC4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933621 – 1325Multidrug resistance-associated protein 4Add BLAST1325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei646PhosphothreonineCombined sources1
Modified residuei648PhosphothreonineCombined sources1
Glycosylationi651N-linked (GlcNAc...)Sequence analysis1
Modified residuei664PhosphoserineCombined sources1
Modified residuei668PhosphoserineCombined sources1
Glycosylationi690N-linked (GlcNAc...)Sequence analysis1
Glycosylationi746N-linked (GlcNAc...)Sequence analysis1
Glycosylationi754N-linked (GlcNAc...)Sequence analysis1
Glycosylationi792N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1176N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1309N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO15439.
MaxQBiO15439.
PaxDbiO15439.
PeptideAtlasiO15439.
PRIDEiO15439.

PTM databases

iPTMnetiO15439.
PhosphoSitePlusiO15439.
SwissPalmiO15439.

Expressioni

Tissue specificityi

Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

Gene expression databases

BgeeiENSG00000125257.
CleanExiHS_ABCC4.
GenevisibleiO15439. HS.

Organism-specific databases

HPAiHPA002476.

Interactioni

Subunit structurei

Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain).1 Publication

Protein-protein interaction databases

BioGridi115551. 17 interactors.
IntActiO15439. 5 interactors.
STRINGi9606.ENSP00000366084.

Chemistry databases

BindingDBiO15439.

Structurei

3D structure databases

ProteinModelPortaliO15439.
SMRiO15439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 377ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST286
Domaini410 – 633ABC transporter 1PROSITE-ProRule annotationAdd BLAST224
Domaini714 – 1005ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST292
Domaini1041 – 1274ABC transporter 2PROSITE-ProRule annotationAdd BLAST234

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1322 – 1325PDZ-binding4

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG108314.
InParanoidiO15439.
KOiK05673.
OMAiCAMFVII.
OrthoDBiEOG091G00IN.
PhylomeDBiO15439.
TreeFamiTF105202.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030240. ABCC4.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF237. PTHR24223:SF237. 1 hit.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15439-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPVYQEVKP NPLQDANLCS RVFFWWLNPL FKIGHKRRLE EDDMYSVLPE
60 70 80 90 100
DRSQHLGEEL QGFWDKEVLR AENDAQKPSL TRAIIKCYWK SYLVLGIFTL
110 120 130 140 150
IEESAKVIQP IFLGKIINYF ENYDPMDSVA LNTAYAYATV LTFCTLILAI
160 170 180 190 200
LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR LSNMAMGKTT TGQIVNLLSN
210 220 230 240 250
DVNKFDQVTV FLHFLWAGPL QAIAVTALLW MEIGISCLAG MAVLIILLPL
260 270 280 290 300
QSCFGKLFSS LRSKTATFTD ARIRTMNEVI TGIRIIKMYA WEKSFSNLIT
310 320 330 340 350
NLRKKEISKI LRSSCLRGMN LASFFSASKI IVFVTFTTYV LLGSVITASR
360 370 380 390 400
VFVAVTLYGA VRLTVTLFFP SAIERVSEAI VSIRRIQTFL LLDEISQRNR
410 420 430 440 450
QLPSDGKKMV HVQDFTAFWD KASETPTLQG LSFTVRPGEL LAVVGPVGAG
460 470 480 490 500
KSSLLSAVLG ELAPSHGLVS VHGRIAYVSQ QPWVFSGTLR SNILFGKKYE
510 520 530 540 550
KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGTTLSGGQK ARVNLARAVY
560 570 580 590 600
QDADIYLLDD PLSAVDAEVS RHLFELCICQ ILHEKITILV THQLQYLKAA
610 620 630 640 650
SQILILKDGK MVQKGTYTEF LKSGIDFGSL LKKDNEESEQ PPVPGTPTLR
660 670 680 690 700
NRTFSESSVW SQQSSRPSLK DGALESQDTE NVPVTLSEEN RSEGKVGFQA
710 720 730 740 750
YKNYFRAGAH WIVFIFLILL NTAAQVAYVL QDWWLSYWAN KQSMLNVTVN
760 770 780 790 800
GGGNVTEKLD LNWYLGIYSG LTVATVLFGI ARSLLVFYVL VNSSQTLHNK
810 820 830 840 850
MFESILKAPV LFFDRNPIGR ILNRFSKDIG HLDDLLPLTF LDFIQTLLQV
860 870 880 890 900
VGVVSVAVAV IPWIAIPLVP LGIIFIFLRR YFLETSRDVK RLESTTRSPV
910 920 930 940 950
FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV
960 970 980 990 1000
RLDAICAMFV IIVAFGSLIL AKTLDAGQVG LALSYALTLM GMFQWCVRQS
1010 1020 1030 1040 1050
AEVENMMISV ERVIEYTDLE KEAPWEYQKR PPPAWPHEGV IIFDNVNFMY
1060 1070 1080 1090 1100
SPGGPLVLKH LTALIKSQEK VGIVGRTGAG KSSLISALFR LSEPEGKIWI
1110 1120 1130 1140 1150
DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE HTDEELWNAL
1160 1170 1180 1190 1200
QEVQLKETIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILRKNQILII
1210 1220 1230 1240 1250
DEATANVDPR TDELIQKKIR EKFAHCTVLT IAHRLNTIID SDKIMVLDSG
1260 1270 1280 1290 1300
RLKEYDEPYV LLQNKESLFY KMVQQLGKAE AAALTETAKQ VYFKRNYPHI
1310 1320
GHTDHMVTNT SNGQPSTLTI FETAL
Length:1,325
Mass (Da):149,527
Last modified:September 23, 2008 - v3
Checksum:iBF2D53136B78C0BA
GO
Isoform 2 (identifier: O15439-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     679-725: Missing.

Show »
Length:1,278
Mass (Da):144,201
Checksum:i1B51AE7536A136E8
GO
Isoform 3 (identifier: O15439-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     846-859: TLLQVVGVVSVAVA → RWDLAVLSWLVSNS
     860-1325: Missing.

Note: No experimental confirmation available.
Show »
Length:859
Mass (Da):96,841
Checksum:iA254809A2F5CE133
GO
Isoform 4 (identifier: O15439-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-177: Missing.
     846-859: TLLQVVGVVSVAVA → RWDLAVLSWLVSNS
     860-1325: Missing.

Note: No experimental confirmation available.
Show »
Length:784
Mass (Da):88,138
Checksum:i2835B9C2A12E164D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti703N → S in AAL88745 (PubMed:12105214).Curated1
Sequence conflicti757E → G in AAL88745 (PubMed:12105214).Curated1
Sequence conflicti893E → G in AAL88745 (PubMed:12105214).Curated1
Sequence conflicti1139N → K in AAC27076 (PubMed:9661885).Curated1
Sequence conflicti1302H → D in AAB71757 (PubMed:9270026).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04644518L → I.2 PublicationsCorresponds to variant rs11568681dbSNPEnsembl.1
Natural variantiVAR_02912178P → A.Corresponds to variant rs11568689dbSNPEnsembl.1
Natural variantiVAR_046446171C → G.Corresponds to variant rs4148460dbSNPEnsembl.1
Natural variantiVAR_020241184M → T.Corresponds to variant rs45454092dbSNPEnsembl.1
Natural variantiVAR_020242187G → W Transport properties comparable to wild-type. 1 PublicationCorresponds to variant rs11568658dbSNPEnsembl.1
Natural variantiVAR_046447293K → E.Corresponds to variant rs11568684dbSNPEnsembl.1
Natural variantiVAR_022072304K → N Transport properties comparable to wild-type. 1 PublicationCorresponds to variant rs2274407dbSNPEnsembl.1
Natural variantiVAR_046448356T → M.Corresponds to variant rs11568701dbSNPEnsembl.1
Natural variantiVAR_029122403P → L.Corresponds to variant rs11568705dbSNPEnsembl.1
Natural variantiVAR_029123487G → E Transport properties comparable to wild-type. 1 PublicationCorresponds to variant rs11568668dbSNPEnsembl.1
Natural variantiVAR_020243498K → E.Corresponds to variant rs11568669dbSNPEnsembl.1
Natural variantiVAR_045684556Y → C 40% reduced expression level compared to wild-type; higher transport of 9-(2-phosphonyl-methoxyethyl) adenine than wild-type. 1 PublicationCorresponds to variant rs753414892dbSNPEnsembl.1
Natural variantiVAR_029124625I → M.Corresponds to variant rs11568699dbSNPEnsembl.1
Natural variantiVAR_029125667P → L.Corresponds to variant rs11568697dbSNPEnsembl.1
Natural variantiVAR_020244744M → V.Corresponds to variant rs9282570dbSNPEnsembl.1
Natural variantiVAR_022073757E → K 10% reduced expression level compared to wild-type; transport properties comparable to wild-type. 2 PublicationsCorresponds to variant rs3765534dbSNPEnsembl.1
Natural variantiVAR_045685776V → I 20% reduced expression level compared to wild-type; significant lower activity in 6-mercaptopurine transport than wild-type. 1 PublicationCorresponds to variant rs146708960dbSNPEnsembl.1
Natural variantiVAR_045686820R → I Transport properties comparable to wild-type. 1 PublicationCorresponds to variant rs11568659dbSNPEnsembl.1
Natural variantiVAR_045687854V → F Transport properties comparable to wild-type. 1 PublicationCorresponds to variant rs11568694dbSNPEnsembl.1
Natural variantiVAR_020245860V → M.Corresponds to variant rs45477596dbSNPEnsembl.1
Natural variantiVAR_045688866I → V Transport properties comparable to wild-type. 1 PublicationCorresponds to variant rs139970608dbSNPEnsembl.1
Natural variantiVAR_020246900V → L.Corresponds to variant rs45504892dbSNPEnsembl.1
Natural variantiVAR_0291261142T → M 10% reduced expression level compared to wild-type; transport properties comparable to wild-type. 1 PublicationCorresponds to variant rs11568644dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057413103 – 177Missing in isoform 4. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_035426679 – 725Missing in isoform 2. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_043283846 – 859TLLQV…SVAVA → RWDLAVLSWLVSNS in isoform 3 and isoform 4. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_043284860 – 1325Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST466

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071202 mRNA. Translation: AAC27076.1.
AY081219 mRNA. Translation: AAL88745.1.
AY207008 mRNA. Translation: AAO37649.1.
AF541977 mRNA. Translation: AAN17334.1.
AK296247 mRNA. Translation: BAH12293.1.
AL157818, AL139381, AL356257 Genomic DNA. Translation: CAC36037.2.
AL139381, AL157818, AL356257 Genomic DNA. Translation: CAI16589.1.
AL356257, AL139381, AL157818 Genomic DNA. Translation: CAI16722.1.
AL359750 Genomic DNA. No translation available.
CH471085 Genomic DNA. Translation: EAX08951.1.
CH471085 Genomic DNA. Translation: EAX08950.1.
BC041560 mRNA. Translation: AAH41560.1.
U83660 mRNA. Translation: AAB71757.1.
CCDSiCCDS45061.1. [O15439-3]
CCDS76643.1. [O15439-4]
CCDS9474.1. [O15439-1]
RefSeqiNP_001098985.1. NM_001105515.2. [O15439-3]
NP_001288758.1. NM_001301829.1. [O15439-2]
NP_001288759.1. NM_001301830.1. [O15439-4]
NP_005836.2. NM_005845.4. [O15439-1]
UniGeneiHs.508423.

Genome annotation databases

EnsembliENST00000376887; ENSP00000366084; ENSG00000125257. [O15439-1]
ENST00000536256; ENSP00000442024; ENSG00000125257. [O15439-4]
ENST00000629385; ENSP00000487081; ENSG00000125257. [O15439-3]
GeneIDi10257.
KEGGihsa:10257.
UCSCiuc001vmd.5. human. [O15439-1]
uc010tih.2. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071202 mRNA. Translation: AAC27076.1.
AY081219 mRNA. Translation: AAL88745.1.
AY207008 mRNA. Translation: AAO37649.1.
AF541977 mRNA. Translation: AAN17334.1.
AK296247 mRNA. Translation: BAH12293.1.
AL157818, AL139381, AL356257 Genomic DNA. Translation: CAC36037.2.
AL139381, AL157818, AL356257 Genomic DNA. Translation: CAI16589.1.
AL356257, AL139381, AL157818 Genomic DNA. Translation: CAI16722.1.
AL359750 Genomic DNA. No translation available.
CH471085 Genomic DNA. Translation: EAX08951.1.
CH471085 Genomic DNA. Translation: EAX08950.1.
BC041560 mRNA. Translation: AAH41560.1.
U83660 mRNA. Translation: AAB71757.1.
CCDSiCCDS45061.1. [O15439-3]
CCDS76643.1. [O15439-4]
CCDS9474.1. [O15439-1]
RefSeqiNP_001098985.1. NM_001105515.2. [O15439-3]
NP_001288758.1. NM_001301829.1. [O15439-2]
NP_001288759.1. NM_001301830.1. [O15439-4]
NP_005836.2. NM_005845.4. [O15439-1]
UniGeneiHs.508423.

3D structure databases

ProteinModelPortaliO15439.
SMRiO15439.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115551. 17 interactors.
IntActiO15439. 5 interactors.
STRINGi9606.ENSP00000366084.

Chemistry databases

BindingDBiO15439.
ChEMBLiCHEMBL1743128.
DrugBankiDB00718. Adefovir Dipivoxil.
DB00770. Alprostadil.
DB01076. Atorvastatin.
DB01327. Cefazolin.
DB00482. Celecoxib.
DB02659. Cholic Acid.
DB00286. Conjugated Estrogens.
DB00586. Diclofenac.
DB00917. Dinoprostone.
DB00975. Dipyridamole.
DB00544. Fluorouracil.
DB00712. Flurbiprofen.
DB00158. Folic Acid.
DB08884. Gadoxetate.
DB00143. Glutathione.
DB01050. Ibuprofen.
DB00328. Indomethacin.
DB01009. Ketoprofen.
DB00709. Lamivudine.
DB00650. Leucovorin.
DB00814. Meloxicam.
DB01033. Mercaptopurine.
DB00563. Methotrexate.
DB00731. Nateglinide.
DB00198. Oseltamivir.
DB01032. Probenecid.
DB01098. Rosuvastatin.
DB00203. Sildenafil.
DB00398. Sorafenib.
DB01138. Sulfinpyrazone.
DB01268. Sunitinib.
DB00300. Tenofovir.
DB00352. Tioguanine.
DB01586. Ursodeoxycholic acid.
DB00661. Verapamil.
DB00495. Zidovudine.
GuidetoPHARMACOLOGYi782.

Protein family/group databases

TCDBi3.A.1.208.7. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiO15439.
PhosphoSitePlusiO15439.
SwissPalmiO15439.

Polymorphism and mutation databases

BioMutaiABCC4.

Proteomic databases

EPDiO15439.
MaxQBiO15439.
PaxDbiO15439.
PeptideAtlasiO15439.
PRIDEiO15439.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376887; ENSP00000366084; ENSG00000125257. [O15439-1]
ENST00000536256; ENSP00000442024; ENSG00000125257. [O15439-4]
ENST00000629385; ENSP00000487081; ENSG00000125257. [O15439-3]
GeneIDi10257.
KEGGihsa:10257.
UCSCiuc001vmd.5. human. [O15439-1]
uc010tih.2. human.

Organism-specific databases

CTDi10257.
DisGeNETi10257.
GeneCardsiABCC4.
HGNCiHGNC:55. ABCC4.
HPAiHPA002476.
MIMi605250. gene.
neXtProtiNX_O15439.
OpenTargetsiENSG00000125257.
PharmGKBiPA397.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG108314.
InParanoidiO15439.
KOiK05673.
OMAiCAMFVII.
OrthoDBiEOG091G00IN.
PhylomeDBiO15439.
TreeFamiTF105202.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125257-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-382556. ABC-family proteins mediated transport.

Miscellaneous databases

ChiTaRSiABCC4. human.
GeneWikiiABCC4.
GenomeRNAii10257.
PROiO15439.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125257.
CleanExiHS_ABCC4.
GenevisibleiO15439. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030240. ABCC4.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF237. PTHR24223:SF237. 1 hit.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP4_HUMAN
AccessioniPrimary (citable) accession number: O15439
Secondary accession number(s): A9Z1Z7
, B7Z3Q7, Q8IVZ4, Q8IZN6, Q8NEW8, Q9Y6J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 167 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.