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O15439 (MRP4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multidrug resistance-associated protein 4
Alternative name(s):
ATP-binding cassette sub-family C member 4
MRP/cMOAT-related ABC transporter
Multi-specific organic anion transporter B
Short name=MOAT-B
Gene names
Name:ABCC4
Synonyms:MRP4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1325 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be an organic anion pump relevant to cellular detoxification.

Subunit structure

Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain). Ref.13

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O15439-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O15439-2)

The sequence of this isoform differs from the canonical sequence as follows:
     679-725: Missing.
Isoform 3 (identifier: O15439-3)

The sequence of this isoform differs from the canonical sequence as follows:
     846-859: TLLQVVGVVSVAVA → RWDLAVLSWLVSNS
     860-1325: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13251325Multidrug resistance-associated protein 4
PRO_0000093362

Regions

Transmembrane93 – 11321Helical; Potential
Transmembrane136 – 15621Helical; Potential
Transmembrane207 – 22721Helical; Potential
Transmembrane228 – 24821Helical; Potential
Transmembrane328 – 34821Helical; Potential
Transmembrane351 – 37121Helical; Potential
Transmembrane440 – 46021Helical; Potential
Transmembrane710 – 73021Helical; Potential
Transmembrane771 – 79121Helical; Potential
Transmembrane836 – 85621Helical; Potential
Transmembrane858 – 87821Helical; Potential
Transmembrane954 – 97421Helical; Potential
Transmembrane977 – 99721Helical; Potential
Transmembrane1038 – 105821Helical; Potential
Domain92 – 377286ABC transmembrane type-1 1
Domain410 – 633224ABC transporter 1
Domain714 – 1005292ABC transmembrane type-1 2
Domain1041 – 1274234ABC transporter 2
Nucleotide binding445 – 4528ATP 1 Potential
Nucleotide binding1075 – 10828ATP 2 Potential
Motif1322 – 13254PDZ-binding

Amino acid modifications

Modified residue6461Phosphothreonine Ref.9 Ref.10 Ref.11
Glycosylation6511N-linked (GlcNAc...) Potential
Glycosylation6901N-linked (GlcNAc...) Potential
Glycosylation7461N-linked (GlcNAc...) Potential
Glycosylation7541N-linked (GlcNAc...) Potential
Glycosylation7921N-linked (GlcNAc...) Potential
Glycosylation11761N-linked (GlcNAc...) Potential
Glycosylation13091N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence679 – 72547Missing in isoform 2.
VSP_035426
Alternative sequence846 – 85914TLLQV…SVAVA → RWDLAVLSWLVSNS in isoform 3.
VSP_043283
Alternative sequence860 – 1325466Missing in isoform 3.
VSP_043284
Natural variant181L → I. Ref.1 Ref.2
Corresponds to variant rs11568681 [ dbSNP | Ensembl ].
VAR_046445
Natural variant781P → A.
Corresponds to variant rs11568689 [ dbSNP | Ensembl ].
VAR_029121
Natural variant1711C → G.
Corresponds to variant rs4148460 [ dbSNP | Ensembl ].
VAR_046446
Natural variant1841M → T.
Corresponds to variant rs45454092 [ dbSNP | Ensembl ].
VAR_020241
Natural variant1871G → W Transport properties comparable to wild-type. Ref.14
Corresponds to variant rs11568658 [ dbSNP | Ensembl ].
VAR_020242
Natural variant2931K → E.
Corresponds to variant rs11568684 [ dbSNP | Ensembl ].
VAR_046447
Natural variant3041K → N Transport properties comparable to wild-type. Ref.14
Corresponds to variant rs2274407 [ dbSNP | Ensembl ].
VAR_022072
Natural variant3561T → M.
Corresponds to variant rs11568701 [ dbSNP | Ensembl ].
VAR_046448
Natural variant4031P → L.
Corresponds to variant rs11568705 [ dbSNP | Ensembl ].
VAR_029122
Natural variant4871G → E Transport properties comparable to wild-type. Ref.14
Corresponds to variant rs11568668 [ dbSNP | Ensembl ].
VAR_029123
Natural variant4981K → E.
Corresponds to variant rs11568669 [ dbSNP | Ensembl ].
VAR_020243
Natural variant5561Y → C 40% reduced expression level compared to wild-type; higher transport of 9-(2-phosphonyl-methoxyethyl) adenine than wild-type. Ref.14
VAR_045684
Natural variant6251I → M.
Corresponds to variant rs11568699 [ dbSNP | Ensembl ].
VAR_029124
Natural variant6671P → L.
Corresponds to variant rs11568697 [ dbSNP | Ensembl ].
VAR_029125
Natural variant7441M → V.
Corresponds to variant rs9282570 [ dbSNP | Ensembl ].
VAR_020244
Natural variant7571E → K 10% reduced expression level compared to wild-type; transport properties comparable to wild-type. Ref.14 Ref.15
Corresponds to variant rs3765534 [ dbSNP | Ensembl ].
VAR_022073
Natural variant7761V → I 20% reduced expression level compared to wild-type; significant lower activity in 6-mercaptopurine transport than wild-type. Ref.14
VAR_045685
Natural variant8201R → I Transport properties comparable to wild-type. Ref.14
Corresponds to variant rs11568659 [ dbSNP | Ensembl ].
VAR_045686
Natural variant8541V → F Transport properties comparable to wild-type. Ref.14
Corresponds to variant rs11568694 [ dbSNP | Ensembl ].
VAR_045687
Natural variant8601V → M.
Corresponds to variant rs45477596 [ dbSNP | Ensembl ].
VAR_020245
Natural variant8661I → V Transport properties comparable to wild-type. Ref.14
Corresponds to variant rs139970608 [ dbSNP | Ensembl ].
VAR_045688
Natural variant9001V → L.
Corresponds to variant rs45504892 [ dbSNP | Ensembl ].
VAR_020246
Natural variant11421T → M 10% reduced expression level compared to wild-type; transport properties comparable to wild-type. Ref.14
Corresponds to variant rs11568644 [ dbSNP | Ensembl ].
VAR_029126

Experimental info

Sequence conflict7031N → S in AAL88745. Ref.2
Sequence conflict7571E → G in AAL88745. Ref.2
Sequence conflict8931E → G in AAL88745. Ref.2
Sequence conflict11391N → K in AAC27076. Ref.1
Sequence conflict13021H → D in AAB71757. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 23, 2008. Version 3.
Checksum: BF2D53136B78C0BA

FASTA1,325149,527
        10         20         30         40         50         60 
MLPVYQEVKP NPLQDANLCS RVFFWWLNPL FKIGHKRRLE EDDMYSVLPE DRSQHLGEEL 

        70         80         90        100        110        120 
QGFWDKEVLR AENDAQKPSL TRAIIKCYWK SYLVLGIFTL IEESAKVIQP IFLGKIINYF 

       130        140        150        160        170        180 
ENYDPMDSVA LNTAYAYATV LTFCTLILAI LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR 

       190        200        210        220        230        240 
LSNMAMGKTT TGQIVNLLSN DVNKFDQVTV FLHFLWAGPL QAIAVTALLW MEIGISCLAG 

       250        260        270        280        290        300 
MAVLIILLPL QSCFGKLFSS LRSKTATFTD ARIRTMNEVI TGIRIIKMYA WEKSFSNLIT 

       310        320        330        340        350        360 
NLRKKEISKI LRSSCLRGMN LASFFSASKI IVFVTFTTYV LLGSVITASR VFVAVTLYGA 

       370        380        390        400        410        420 
VRLTVTLFFP SAIERVSEAI VSIRRIQTFL LLDEISQRNR QLPSDGKKMV HVQDFTAFWD 

       430        440        450        460        470        480 
KASETPTLQG LSFTVRPGEL LAVVGPVGAG KSSLLSAVLG ELAPSHGLVS VHGRIAYVSQ 

       490        500        510        520        530        540 
QPWVFSGTLR SNILFGKKYE KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGTTLSGGQK 

       550        560        570        580        590        600 
ARVNLARAVY QDADIYLLDD PLSAVDAEVS RHLFELCICQ ILHEKITILV THQLQYLKAA 

       610        620        630        640        650        660 
SQILILKDGK MVQKGTYTEF LKSGIDFGSL LKKDNEESEQ PPVPGTPTLR NRTFSESSVW 

       670        680        690        700        710        720 
SQQSSRPSLK DGALESQDTE NVPVTLSEEN RSEGKVGFQA YKNYFRAGAH WIVFIFLILL 

       730        740        750        760        770        780 
NTAAQVAYVL QDWWLSYWAN KQSMLNVTVN GGGNVTEKLD LNWYLGIYSG LTVATVLFGI 

       790        800        810        820        830        840 
ARSLLVFYVL VNSSQTLHNK MFESILKAPV LFFDRNPIGR ILNRFSKDIG HLDDLLPLTF 

       850        860        870        880        890        900 
LDFIQTLLQV VGVVSVAVAV IPWIAIPLVP LGIIFIFLRR YFLETSRDVK RLESTTRSPV 

       910        920        930        940        950        960 
FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV RLDAICAMFV 

       970        980        990       1000       1010       1020 
IIVAFGSLIL AKTLDAGQVG LALSYALTLM GMFQWCVRQS AEVENMMISV ERVIEYTDLE 

      1030       1040       1050       1060       1070       1080 
KEAPWEYQKR PPPAWPHEGV IIFDNVNFMY SPGGPLVLKH LTALIKSQEK VGIVGRTGAG 

      1090       1100       1110       1120       1130       1140 
KSSLISALFR LSEPEGKIWI DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE 

      1150       1160       1170       1180       1190       1200 
HTDEELWNAL QEVQLKETIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILRKNQILII 

      1210       1220       1230       1240       1250       1260 
DEATANVDPR TDELIQKKIR EKFAHCTVLT IAHRLNTIID SDKIMVLDSG RLKEYDEPYV 

      1270       1280       1290       1300       1310       1320 
LLQNKESLFY KMVQQLGKAE AAALTETAKQ VYFKRNYPHI GHTDHMVTNT SNGQPSTLTI 


FETAL 

« Hide

Isoform 2 [UniParc].

Checksum: 1B51AE7536A136E8
Show »

FASTA1,278144,201
Isoform 3 [UniParc].

Checksum: A254809A2F5CE133
Show »

FASTA85996,841

References

« Hide 'large scale' references
[1]"Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter."
Lee K., Belinsky M.G., Bell D.W., Testa J.R., Kruh G.D.
Cancer Res. 58:2741-2747(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-18.
[2]"Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing."
Adachi M., Sampath J., Lan L.B., Sun D., Hargrove P., Flatley R., Tatum A., Edwards M.Z., Wezeman M., Matherly L., Drake R., Schuetz J.
J. Biol. Chem. 277:38998-39004(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-18.
[3]Kato R., Ishikawa T.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Kidney.
[4]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[7]"Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines."
Kool M., de Haas M., Scheffer G.L., Scheper R.J., van Eijk M.J., Juijn J.A., Baas F., Borst P.
Cancer Res. 57:3537-3547(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1155-1316 (ISOFORMS 1/2).
Tissue: Brain.
[8]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4."
Hayashi H., Naoi S., Nakagawa T., Nishikawa T., Fukuda H., Imajoh-Ohmi S., Kondo A., Kubo K., Yabuki T., Hattori A., Hirouchi M., Sugiyama Y.
J. Biol. Chem. 287:15054-15065(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SNX27.
[14]"6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4."
Janke D., Mehralivand S., Strand D., Goedtel-Armbrust U., Habermeier A., Gradhand U., Fischer C., Toliat M.R., Fritz P., Zanger U.M., Schwab M., Fromm M.F., Nuernberg P., Wojnowski L., Closs E.I., Lang T.
Hum. Mutat. 29:659-669(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS CYS-556; ILE-776; ILE-820; PHE-854 AND VAL-866, CHARACTERIZATION OF VARIANTS TRP-187; ASN-304; GLU-487; CYS-556; LYS-757; ILE-776; ILE-820; PHE-854; VAL-866 AND MET-1142.
[15]"A Japanese-specific allele in the GALNT11 gene."
Yuasa I., Umetsu K., Matsusue A., Nishimukai H., Harihara S., Fukumori Y., Saitou N., Jin F., Chattopadhyay P.K., Henke L., Henke J.
Leg. Med. 12:208-211(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LYS-757.
+Additional computationally mapped references.

Web resources

ABCMdb

Database for mutations in ABC proteins

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF071202 mRNA. Translation: AAC27076.1.
AY081219 mRNA. Translation: AAL88745.1.
AY207008 mRNA. Translation: AAO37649.1.
AF541977 mRNA. Translation: AAN17334.1.
AL157818, AL139381, AL356257 Genomic DNA. Translation: CAC36037.2.
AL139381, AL157818, AL356257 Genomic DNA. Translation: CAI16589.1.
AL356257, AL139381, AL157818 Genomic DNA. Translation: CAI16722.1.
AL359750 Genomic DNA. No translation available.
CH471085 Genomic DNA. Translation: EAX08951.1.
CH471085 Genomic DNA. Translation: EAX08950.1.
BC041560 mRNA. Translation: AAH41560.1.
U83660 mRNA. Translation: AAB71757.1.
CCDSCCDS45061.1. [O15439-3]
CCDS9474.1. [O15439-1]
RefSeqNP_001098985.1. NM_001105515.1. [O15439-3]
NP_005836.2. NM_005845.3. [O15439-1]
UniGeneHs.508423.

3D structure databases

ProteinModelPortalO15439.
SMRO15439. Positions 92-650, 797-1272.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115551. 9 interactions.
IntActO15439. 1 interaction.
STRING9606.ENSP00000366084.

Chemistry

ChEMBLCHEMBL1743128.
DrugBankDB01327. Cefazolin.

Protein family/group databases

TCDB3.A.1.208.7. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSiteO15439.

Proteomic databases

MaxQBO15439.
PaxDbO15439.
PRIDEO15439.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376887; ENSP00000366084; ENSG00000125257. [O15439-1]
ENST00000412704; ENSP00000388657; ENSG00000125257. [O15439-2]
ENST00000431522; ENSP00000398562; ENSG00000125257. [O15439-3]
GeneID10257.
KEGGhsa:10257.
UCSCuc001vmd.4. human. [O15439-1]
uc001vme.2. human. [O15439-3]
uc010afk.3. human. [O15439-2]

Organism-specific databases

CTD10257.
GeneCardsGC13M095672.
HGNCHGNC:55. ABCC4.
HPACAB002751.
HPA002476.
MIM605250. gene.
neXtProtNX_O15439.
PharmGKBPA397.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1132.
HOVERGENHBG108314.
InParanoidO15439.
KOK05673.
OMACAMFVII.
OrthoDBEOG7MWGW0.
PhylomeDBO15439.
TreeFamTF105202.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_604. Hemostasis.

Gene expression databases

ArrayExpressO15439.
BgeeO15439.
CleanExHS_ABCC4.
GenevestigatorO15439.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiABCC4.
GenomeRNAi10257.
NextBio38868.
PROO15439.
SOURCESearch...

Entry information

Entry nameMRP4_HUMAN
AccessionPrimary (citable) accession number: O15439
Secondary accession number(s): A9Z1Z7 expand/collapse secondary AC list , Q8IVZ4, Q8IZN6, Q8NEW8, Q9Y6J2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM