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O15439

- MRP4_HUMAN

UniProt

O15439 - MRP4_HUMAN

Protein

Multidrug resistance-associated protein 4

Gene

ABCC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 3 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    May be an organic anion pump relevant to cellular detoxification.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi445 – 4528ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1075 – 10828ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. 15-hydroxyprostaglandin dehydrogenase (NAD+) activity Source: UniProtKB
    2. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    3. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. oxidation-reduction process Source: GOC
    3. platelet activation Source: Reactome
    4. platelet degranulation Source: Reactome
    5. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_15480. ABC-family proteins mediated transport.

    Protein family/group databases

    TCDBi3.A.1.208.7. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug resistance-associated protein 4
    Alternative name(s):
    ATP-binding cassette sub-family C member 4
    MRP/cMOAT-related ABC transporter
    Multi-specific organic anion transporter B
    Short name:
    MOAT-B
    Gene namesi
    Name:ABCC4
    Synonyms:MRP4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:55. ABCC4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB
    3. plasma membrane Source: MGI
    4. platelet dense granule membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA397.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13251325Multidrug resistance-associated protein 4PRO_0000093362Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei646 – 6461Phosphothreonine3 Publications
    Glycosylationi651 – 6511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi690 – 6901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi746 – 7461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi754 – 7541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi792 – 7921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1176 – 11761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1309 – 13091N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO15439.
    PaxDbiO15439.
    PRIDEiO15439.

    PTM databases

    PhosphoSiteiO15439.

    Expressioni

    Tissue specificityi

    Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

    Gene expression databases

    ArrayExpressiO15439.
    BgeeiO15439.
    CleanExiHS_ABCC4.
    GenevestigatoriO15439.

    Organism-specific databases

    HPAiCAB002751.
    HPA002476.

    Interactioni

    Subunit structurei

    Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain).1 Publication

    Protein-protein interaction databases

    BioGridi115551. 9 interactions.
    IntActiO15439. 1 interaction.
    STRINGi9606.ENSP00000366084.

    Structurei

    3D structure databases

    ProteinModelPortaliO15439.
    SMRiO15439. Positions 92-650, 797-1272.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei93 – 11321HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei136 – 15621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei207 – 22721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei228 – 24821HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei328 – 34821HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei351 – 37121HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei440 – 46021HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei710 – 73021HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei771 – 79121HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei836 – 85621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei858 – 87821HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei954 – 97421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei977 – 99721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1038 – 105821HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini92 – 377286ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini410 – 633224ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini714 – 1005292ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1041 – 1274234ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1322 – 13254PDZ-binding

    Sequence similaritiesi

    Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    HOVERGENiHBG108314.
    InParanoidiO15439.
    KOiK05673.
    OMAiCAMFVII.
    OrthoDBiEOG7MWGW0.
    PhylomeDBiO15439.
    TreeFamiTF105202.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O15439-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLPVYQEVKP NPLQDANLCS RVFFWWLNPL FKIGHKRRLE EDDMYSVLPE     50
    DRSQHLGEEL QGFWDKEVLR AENDAQKPSL TRAIIKCYWK SYLVLGIFTL 100
    IEESAKVIQP IFLGKIINYF ENYDPMDSVA LNTAYAYATV LTFCTLILAI 150
    LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR LSNMAMGKTT TGQIVNLLSN 200
    DVNKFDQVTV FLHFLWAGPL QAIAVTALLW MEIGISCLAG MAVLIILLPL 250
    QSCFGKLFSS LRSKTATFTD ARIRTMNEVI TGIRIIKMYA WEKSFSNLIT 300
    NLRKKEISKI LRSSCLRGMN LASFFSASKI IVFVTFTTYV LLGSVITASR 350
    VFVAVTLYGA VRLTVTLFFP SAIERVSEAI VSIRRIQTFL LLDEISQRNR 400
    QLPSDGKKMV HVQDFTAFWD KASETPTLQG LSFTVRPGEL LAVVGPVGAG 450
    KSSLLSAVLG ELAPSHGLVS VHGRIAYVSQ QPWVFSGTLR SNILFGKKYE 500
    KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGTTLSGGQK ARVNLARAVY 550
    QDADIYLLDD PLSAVDAEVS RHLFELCICQ ILHEKITILV THQLQYLKAA 600
    SQILILKDGK MVQKGTYTEF LKSGIDFGSL LKKDNEESEQ PPVPGTPTLR 650
    NRTFSESSVW SQQSSRPSLK DGALESQDTE NVPVTLSEEN RSEGKVGFQA 700
    YKNYFRAGAH WIVFIFLILL NTAAQVAYVL QDWWLSYWAN KQSMLNVTVN 750
    GGGNVTEKLD LNWYLGIYSG LTVATVLFGI ARSLLVFYVL VNSSQTLHNK 800
    MFESILKAPV LFFDRNPIGR ILNRFSKDIG HLDDLLPLTF LDFIQTLLQV 850
    VGVVSVAVAV IPWIAIPLVP LGIIFIFLRR YFLETSRDVK RLESTTRSPV 900
    FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV 950
    RLDAICAMFV IIVAFGSLIL AKTLDAGQVG LALSYALTLM GMFQWCVRQS 1000
    AEVENMMISV ERVIEYTDLE KEAPWEYQKR PPPAWPHEGV IIFDNVNFMY 1050
    SPGGPLVLKH LTALIKSQEK VGIVGRTGAG KSSLISALFR LSEPEGKIWI 1100
    DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE HTDEELWNAL 1150
    QEVQLKETIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILRKNQILII 1200
    DEATANVDPR TDELIQKKIR EKFAHCTVLT IAHRLNTIID SDKIMVLDSG 1250
    RLKEYDEPYV LLQNKESLFY KMVQQLGKAE AAALTETAKQ VYFKRNYPHI 1300
    GHTDHMVTNT SNGQPSTLTI FETAL 1325
    Length:1,325
    Mass (Da):149,527
    Last modified:September 23, 2008 - v3
    Checksum:iBF2D53136B78C0BA
    GO
    Isoform 2 (identifier: O15439-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         679-725: Missing.

    Show »
    Length:1,278
    Mass (Da):144,201
    Checksum:i1B51AE7536A136E8
    GO
    Isoform 3 (identifier: O15439-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         846-859: TLLQVVGVVSVAVA → RWDLAVLSWLVSNS
         860-1325: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:859
    Mass (Da):96,841
    Checksum:iA254809A2F5CE133
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti703 – 7031N → S in AAL88745. (PubMed:12105214)Curated
    Sequence conflicti757 – 7571E → G in AAL88745. (PubMed:12105214)Curated
    Sequence conflicti893 – 8931E → G in AAL88745. (PubMed:12105214)Curated
    Sequence conflicti1139 – 11391N → K in AAC27076. (PubMed:9661885)Curated
    Sequence conflicti1302 – 13021H → D in AAB71757. (PubMed:9270026)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181L → I.2 Publications
    Corresponds to variant rs11568681 [ dbSNP | Ensembl ].
    VAR_046445
    Natural varianti78 – 781P → A.
    Corresponds to variant rs11568689 [ dbSNP | Ensembl ].
    VAR_029121
    Natural varianti171 – 1711C → G.
    Corresponds to variant rs4148460 [ dbSNP | Ensembl ].
    VAR_046446
    Natural varianti184 – 1841M → T.
    Corresponds to variant rs45454092 [ dbSNP | Ensembl ].
    VAR_020241
    Natural varianti187 – 1871G → W Transport properties comparable to wild-type.
    Corresponds to variant rs11568658 [ dbSNP | Ensembl ].
    VAR_020242
    Natural varianti293 – 2931K → E.
    Corresponds to variant rs11568684 [ dbSNP | Ensembl ].
    VAR_046447
    Natural varianti304 – 3041K → N Transport properties comparable to wild-type.
    Corresponds to variant rs2274407 [ dbSNP | Ensembl ].
    VAR_022072
    Natural varianti356 – 3561T → M.
    Corresponds to variant rs11568701 [ dbSNP | Ensembl ].
    VAR_046448
    Natural varianti403 – 4031P → L.
    Corresponds to variant rs11568705 [ dbSNP | Ensembl ].
    VAR_029122
    Natural varianti487 – 4871G → E Transport properties comparable to wild-type.
    Corresponds to variant rs11568668 [ dbSNP | Ensembl ].
    VAR_029123
    Natural varianti498 – 4981K → E.
    Corresponds to variant rs11568669 [ dbSNP | Ensembl ].
    VAR_020243
    Natural varianti556 – 5561Y → C 40% reduced expression level compared to wild-type; higher transport of 9-(2-phosphonyl-methoxyethyl) adenine than wild-type. 1 Publication
    VAR_045684
    Natural varianti625 – 6251I → M.
    Corresponds to variant rs11568699 [ dbSNP | Ensembl ].
    VAR_029124
    Natural varianti667 – 6671P → L.
    Corresponds to variant rs11568697 [ dbSNP | Ensembl ].
    VAR_029125
    Natural varianti744 – 7441M → V.
    Corresponds to variant rs9282570 [ dbSNP | Ensembl ].
    VAR_020244
    Natural varianti757 – 7571E → K 10% reduced expression level compared to wild-type; transport properties comparable to wild-type. 1 Publication
    Corresponds to variant rs3765534 [ dbSNP | Ensembl ].
    VAR_022073
    Natural varianti776 – 7761V → I 20% reduced expression level compared to wild-type; significant lower activity in 6-mercaptopurine transport than wild-type. 1 Publication
    VAR_045685
    Natural varianti820 – 8201R → I Transport properties comparable to wild-type. 1 Publication
    Corresponds to variant rs11568659 [ dbSNP | Ensembl ].
    VAR_045686
    Natural varianti854 – 8541V → F Transport properties comparable to wild-type. 1 Publication
    Corresponds to variant rs11568694 [ dbSNP | Ensembl ].
    VAR_045687
    Natural varianti860 – 8601V → M.
    Corresponds to variant rs45477596 [ dbSNP | Ensembl ].
    VAR_020245
    Natural varianti866 – 8661I → V Transport properties comparable to wild-type. 1 Publication
    Corresponds to variant rs139970608 [ dbSNP | Ensembl ].
    VAR_045688
    Natural varianti900 – 9001V → L.
    Corresponds to variant rs45504892 [ dbSNP | Ensembl ].
    VAR_020246
    Natural varianti1142 – 11421T → M 10% reduced expression level compared to wild-type; transport properties comparable to wild-type.
    Corresponds to variant rs11568644 [ dbSNP | Ensembl ].
    VAR_029126

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei679 – 72547Missing in isoform 2. 1 PublicationVSP_035426Add
    BLAST
    Alternative sequencei846 – 85914TLLQV…SVAVA → RWDLAVLSWLVSNS in isoform 3. 1 PublicationVSP_043283Add
    BLAST
    Alternative sequencei860 – 1325466Missing in isoform 3. 1 PublicationVSP_043284Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071202 mRNA. Translation: AAC27076.1.
    AY081219 mRNA. Translation: AAL88745.1.
    AY207008 mRNA. Translation: AAO37649.1.
    AF541977 mRNA. Translation: AAN17334.1.
    AL157818, AL139381, AL356257 Genomic DNA. Translation: CAC36037.2.
    AL139381, AL157818, AL356257 Genomic DNA. Translation: CAI16589.1.
    AL356257, AL139381, AL157818 Genomic DNA. Translation: CAI16722.1.
    AL359750 Genomic DNA. No translation available.
    CH471085 Genomic DNA. Translation: EAX08951.1.
    CH471085 Genomic DNA. Translation: EAX08950.1.
    BC041560 mRNA. Translation: AAH41560.1.
    U83660 mRNA. Translation: AAB71757.1.
    CCDSiCCDS45061.1. [O15439-3]
    CCDS9474.1. [O15439-1]
    RefSeqiNP_001098985.1. NM_001105515.1. [O15439-3]
    NP_005836.2. NM_005845.3. [O15439-1]
    UniGeneiHs.508423.

    Genome annotation databases

    EnsembliENST00000376887; ENSP00000366084; ENSG00000125257. [O15439-1]
    GeneIDi10257.
    KEGGihsa:10257.
    UCSCiuc001vmd.4. human. [O15439-1]
    uc001vme.2. human. [O15439-3]
    uc010afk.3. human. [O15439-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    ABCMdb

    Database for mutations in ABC proteins

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071202 mRNA. Translation: AAC27076.1 .
    AY081219 mRNA. Translation: AAL88745.1 .
    AY207008 mRNA. Translation: AAO37649.1 .
    AF541977 mRNA. Translation: AAN17334.1 .
    AL157818 , AL139381 , AL356257 Genomic DNA. Translation: CAC36037.2 .
    AL139381 , AL157818 , AL356257 Genomic DNA. Translation: CAI16589.1 .
    AL356257 , AL139381 , AL157818 Genomic DNA. Translation: CAI16722.1 .
    AL359750 Genomic DNA. No translation available.
    CH471085 Genomic DNA. Translation: EAX08951.1 .
    CH471085 Genomic DNA. Translation: EAX08950.1 .
    BC041560 mRNA. Translation: AAH41560.1 .
    U83660 mRNA. Translation: AAB71757.1 .
    CCDSi CCDS45061.1. [O15439-3 ]
    CCDS9474.1. [O15439-1 ]
    RefSeqi NP_001098985.1. NM_001105515.1. [O15439-3 ]
    NP_005836.2. NM_005845.3. [O15439-1 ]
    UniGenei Hs.508423.

    3D structure databases

    ProteinModelPortali O15439.
    SMRi O15439. Positions 92-650, 797-1272.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115551. 9 interactions.
    IntActi O15439. 1 interaction.
    STRINGi 9606.ENSP00000366084.

    Chemistry

    ChEMBLi CHEMBL1743128.
    DrugBanki DB00718. Adefovir Dipivoxil.
    DB00770. Alprostadil.
    DB01076. Atorvastatin.
    DB01327. Cefazolin.
    DB00482. Celecoxib.
    DB00286. Conjugated Estrogens.
    DB00586. Diclofenac.
    DB00917. Dinoprostone.
    DB00975. Dipyridamole.
    DB00544. Fluorouracil.
    DB00712. Flurbiprofen.
    DB00158. Folic Acid.
    DB08884. Gadoxetate.
    DB00143. Glutathione.
    DB01050. Ibuprofen.
    DB00328. Indomethacin.
    DB01009. Ketoprofen.
    DB00709. Lamivudine.
    DB00650. Leucovorin.
    DB00814. Meloxicam.
    DB01033. Mercaptopurine.
    DB00563. Methotrexate.
    DB00731. Nateglinide.
    DB00198. Oseltamivir.
    DB01032. Probenecid.
    DB01098. Rosuvastatin.
    DB00203. Sildenafil.
    DB00398. Sorafenib.
    DB01138. Sulfinpyrazone.
    DB01268. Sunitinib.
    DB00300. Tenofovir.
    DB00352. Tioguanine.
    DB01586. Ursodeoxycholic acid.
    DB00661. Verapamil.
    DB00495. Zidovudine.

    Protein family/group databases

    TCDBi 3.A.1.208.7. the atp-binding cassette (abc) superfamily.

    PTM databases

    PhosphoSitei O15439.

    Proteomic databases

    MaxQBi O15439.
    PaxDbi O15439.
    PRIDEi O15439.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376887 ; ENSP00000366084 ; ENSG00000125257 . [O15439-1 ]
    GeneIDi 10257.
    KEGGi hsa:10257.
    UCSCi uc001vmd.4. human. [O15439-1 ]
    uc001vme.2. human. [O15439-3 ]
    uc010afk.3. human. [O15439-2 ]

    Organism-specific databases

    CTDi 10257.
    GeneCardsi GC13M095672.
    HGNCi HGNC:55. ABCC4.
    HPAi CAB002751.
    HPA002476.
    MIMi 605250. gene.
    neXtProti NX_O15439.
    PharmGKBi PA397.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1132.
    HOVERGENi HBG108314.
    InParanoidi O15439.
    KOi K05673.
    OMAi CAMFVII.
    OrthoDBi EOG7MWGW0.
    PhylomeDBi O15439.
    TreeFami TF105202.

    Enzyme and pathway databases

    Reactomei REACT_15480. ABC-family proteins mediated transport.

    Miscellaneous databases

    GeneWikii ABCC4.
    GenomeRNAii 10257.
    NextBioi 38868.
    PROi O15439.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15439.
    Bgeei O15439.
    CleanExi HS_ABCC4.
    Genevestigatori O15439.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter."
      Lee K., Belinsky M.G., Bell D.W., Testa J.R., Kruh G.D.
      Cancer Res. 58:2741-2747(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-18.
    2. "Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing."
      Adachi M., Sampath J., Lan L.B., Sun D., Hargrove P., Flatley R., Tatum A., Edwards M.Z., Wezeman M., Matherly L., Drake R., Schuetz J.
      J. Biol. Chem. 277:38998-39004(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-18.
    3. Kato R., Ishikawa T.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Kidney.
    4. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    7. "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines."
      Kool M., de Haas M., Scheffer G.L., Scheper R.J., van Eijk M.J., Juijn J.A., Baas F., Borst P.
      Cancer Res. 57:3537-3547(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1155-1316 (ISOFORMS 1/2).
      Tissue: Brain.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4."
      Hayashi H., Naoi S., Nakagawa T., Nishikawa T., Fukuda H., Imajoh-Ohmi S., Kondo A., Kubo K., Yabuki T., Hattori A., Hirouchi M., Sugiyama Y.
      J. Biol. Chem. 287:15054-15065(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNX27.
    14. "6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4."
      Janke D., Mehralivand S., Strand D., Goedtel-Armbrust U., Habermeier A., Gradhand U., Fischer C., Toliat M.R., Fritz P., Zanger U.M., Schwab M., Fromm M.F., Nuernberg P., Wojnowski L., Closs E.I., Lang T.
      Hum. Mutat. 29:659-669(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CYS-556; ILE-776; ILE-820; PHE-854 AND VAL-866, CHARACTERIZATION OF VARIANTS TRP-187; ASN-304; GLU-487; CYS-556; LYS-757; ILE-776; ILE-820; PHE-854; VAL-866 AND MET-1142.
    15. Cited for: VARIANT LYS-757.

    Entry informationi

    Entry nameiMRP4_HUMAN
    AccessioniPrimary (citable) accession number: O15439
    Secondary accession number(s): A9Z1Z7
    , Q8IVZ4, Q8IZN6, Q8NEW8, Q9Y6J2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 142 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3