O15439 (MRP4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Multidrug resistance-associated protein 4

Alternative name(s):
ATP-binding cassette sub-family C member 4
MRP/cMOAT-related ABC transporter
Multi-specific organic anion transporter B
Short name=MOAT-B

Gene names

Name:	ABCC4
Synonyms:	MRP4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1325 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be an organic anion pump relevant to cellular detoxification.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC platelet activation Traceable author statement. Source: Reactome platelet degranulation Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay PubMed 15297306. Source: MGI platelet dense granule membrane Inferred from direct assay PubMed 15297306. Source: MGI
Molecular_function	15-hydroxyprostaglandin dehydrogenase (NAD+) activity Non-traceable author statement PubMed 7557451. Source: UniProtKB ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O15439-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O15439-2)

The sequence of this isoform differs from the canonical sequence as follows:
     679-725: Missing.

Isoform 3 (identifier: O15439-3)

The sequence of this isoform differs from the canonical sequence as follows:
     846-859: TLLQVVGVVSVAVA → RWDLAVLSWLVSNS
     860-1325: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1325	1325	Multidrug resistance-associated protein 4		PRO_0000093362
Regions
	Transmembrane	93 – 113	21	Helical; Potential
	Transmembrane	136 – 156	21	Helical; Potential
	Transmembrane	207 – 227	21	Helical; Potential
	Transmembrane	228 – 248	21	Helical; Potential
	Transmembrane	328 – 348	21	Helical; Potential
	Transmembrane	351 – 371	21	Helical; Potential
	Transmembrane	440 – 460	21	Helical; Potential
	Transmembrane	710 – 730	21	Helical; Potential
	Transmembrane	771 – 791	21	Helical; Potential
	Transmembrane	836 – 856	21	Helical; Potential
	Transmembrane	858 – 878	21	Helical; Potential
	Transmembrane	954 – 974	21	Helical; Potential
	Transmembrane	977 – 997	21	Helical; Potential
	Transmembrane	1038 – 1058	21	Helical; Potential
	Domain	92 – 377	286	ABC transmembrane type-1 1
	Domain	410 – 633	224	ABC transporter 1
	Domain	714 – 1005	292	ABC transmembrane type-1 2
	Domain	1041 – 1274	234	ABC transporter 2
	Nucleotide binding	445 – 452	8	ATP 1 Potential
	Nucleotide binding	1075 – 1082	8	ATP 2 Potential
Amino acid modifications
	Modified residue	646	1	Phosphothreonine Ref.9 Ref.10 Ref.11
	Glycosylation	651	1	N-linked (GlcNAc...) Potential
	Glycosylation	690	1	N-linked (GlcNAc...) Potential
	Glycosylation	746	1	N-linked (GlcNAc...) Potential
	Glycosylation	754	1	N-linked (GlcNAc...) Potential
	Glycosylation	792	1	N-linked (GlcNAc...) Potential
	Glycosylation	1176	1	N-linked (GlcNAc...) Potential
	Glycosylation	1309	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	679 – 725	47	Missing in isoform 2.		VSP_035426
	Alternative sequence	846 – 859	14	TLLQV…SVAVA → RWDLAVLSWLVSNS in isoform 3.		VSP_043283
	Alternative sequence	860 – 1325	466	Missing in isoform 3.		VSP_043284
	Natural variant	18	1	L → I. Ref.1 Ref.2 Corresponds to variant rs11568681 [ dbSNP | Ensembl ].		VAR_046445
	Natural variant	78	1	P → A. Corresponds to variant rs11568689 [ dbSNP | Ensembl ].		VAR_029121
	Natural variant	171	1	C → G. Corresponds to variant rs4148460 [ dbSNP | Ensembl ].		VAR_046446
	Natural variant	184	1	M → T. Corresponds to variant rs45454092 [ dbSNP | Ensembl ].		VAR_020241
	Natural variant	187	1	G → W Transport properties comparable to wild-type. Ref.13 Corresponds to variant rs11568658 [ dbSNP | Ensembl ].		VAR_020242
	Natural variant	293	1	K → E. Corresponds to variant rs11568684 [ dbSNP | Ensembl ].		VAR_046447
	Natural variant	304	1	K → N Transport properties comparable to wild-type. Ref.13 Corresponds to variant rs2274407 [ dbSNP | Ensembl ].		VAR_022072
	Natural variant	356	1	T → M. Corresponds to variant rs11568701 [ dbSNP | Ensembl ].		VAR_046448
	Natural variant	403	1	P → L. Corresponds to variant rs11568705 [ dbSNP | Ensembl ].		VAR_029122
	Natural variant	487	1	G → E Transport properties comparable to wild-type. Ref.13 Corresponds to variant rs11568668 [ dbSNP | Ensembl ].		VAR_029123
	Natural variant	498	1	K → E. Corresponds to variant rs11568669 [ dbSNP | Ensembl ].		VAR_020243
	Natural variant	556	1	Y → C 40% reduced expression level compared to wild-type; higher transport of 9-(2-phosphonyl-methoxyethyl) adenine than wild-type. Ref.13		VAR_045684
	Natural variant	625	1	I → M. Corresponds to variant rs11568699 [ dbSNP | Ensembl ].		VAR_029124
	Natural variant	667	1	P → L. Corresponds to variant rs11568697 [ dbSNP | Ensembl ].		VAR_029125
	Natural variant	744	1	M → V. Corresponds to variant rs9282570 [ dbSNP | Ensembl ].		VAR_020244
	Natural variant	757	1	E → K 10% reduced expression level compared to wild-type; transport properties comparable to wild-type. Ref.13 Corresponds to variant rs3765534 [ dbSNP | Ensembl ].		VAR_022073
	Natural variant	776	1	V → I 20% reduced expression level compared to wild-type; significant lower activity in 6-mercaptopurine transport than wild-type. Ref.13		VAR_045685
	Natural variant	820	1	R → I Transport properties comparable to wild-type. Ref.13 Corresponds to variant rs11568659 [ dbSNP | Ensembl ].		VAR_045686
	Natural variant	854	1	V → F Transport properties comparable to wild-type. Ref.13		VAR_045687
	Natural variant	860	1	V → M. Corresponds to variant rs45477596 [ dbSNP | Ensembl ].		VAR_020245
	Natural variant	866	1	I → V Transport properties comparable to wild-type. Ref.13		VAR_045688
	Natural variant	900	1	V → L. Corresponds to variant rs45504892 [ dbSNP | Ensembl ].		VAR_020246
	Natural variant	1142	1	T → M 10% reduced expression level compared to wild-type; transport properties comparable to wild-type. Ref.13		VAR_029126
Experimental info
	Sequence conflict	703	1	N → S in AAL88745. Ref.2
	Sequence conflict	757	1	E → G in AAL88745. Ref.2
	Sequence conflict	893	1	E → G in AAL88745. Ref.2
	Sequence conflict	1139	1	N → K in AAC27076. Ref.1
	Sequence conflict	1302	1	H → D in AAB71757. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 23, 2008. Version 3. Checksum: BF2D53136B78C0BA	FASTA	1,325	149,527
	10 20 30 40 50 60 MLPVYQEVKP NPLQDANLCS RVFFWWLNPL FKIGHKRRLE EDDMYSVLPE DRSQHLGEEL 70 80 90 100 110 120 QGFWDKEVLR AENDAQKPSL TRAIIKCYWK SYLVLGIFTL IEESAKVIQP IFLGKIINYF 130 140 150 160 170 180 ENYDPMDSVA LNTAYAYATV LTFCTLILAI LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR 190 200 210 220 230 240 LSNMAMGKTT TGQIVNLLSN DVNKFDQVTV FLHFLWAGPL QAIAVTALLW MEIGISCLAG 250 260 270 280 290 300 MAVLIILLPL QSCFGKLFSS LRSKTATFTD ARIRTMNEVI TGIRIIKMYA WEKSFSNLIT 310 320 330 340 350 360 NLRKKEISKI LRSSCLRGMN LASFFSASKI IVFVTFTTYV LLGSVITASR VFVAVTLYGA 370 380 390 400 410 420 VRLTVTLFFP SAIERVSEAI VSIRRIQTFL LLDEISQRNR QLPSDGKKMV HVQDFTAFWD 430 440 450 460 470 480 KASETPTLQG LSFTVRPGEL LAVVGPVGAG KSSLLSAVLG ELAPSHGLVS VHGRIAYVSQ 490 500 510 520 530 540 QPWVFSGTLR SNILFGKKYE KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGTTLSGGQK 550 560 570 580 590 600 ARVNLARAVY QDADIYLLDD PLSAVDAEVS RHLFELCICQ ILHEKITILV THQLQYLKAA 610 620 630 640 650 660 SQILILKDGK MVQKGTYTEF LKSGIDFGSL LKKDNEESEQ PPVPGTPTLR NRTFSESSVW 670 680 690 700 710 720 SQQSSRPSLK DGALESQDTE NVPVTLSEEN RSEGKVGFQA YKNYFRAGAH WIVFIFLILL 730 740 750 760 770 780 NTAAQVAYVL QDWWLSYWAN KQSMLNVTVN GGGNVTEKLD LNWYLGIYSG LTVATVLFGI 790 800 810 820 830 840 ARSLLVFYVL VNSSQTLHNK MFESILKAPV LFFDRNPIGR ILNRFSKDIG HLDDLLPLTF 850 860 870 880 890 900 LDFIQTLLQV VGVVSVAVAV IPWIAIPLVP LGIIFIFLRR YFLETSRDVK RLESTTRSPV 910 920 930 940 950 960 FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV RLDAICAMFV 970 980 990 1000 1010 1020 IIVAFGSLIL AKTLDAGQVG LALSYALTLM GMFQWCVRQS AEVENMMISV ERVIEYTDLE 1030 1040 1050 1060 1070 1080 KEAPWEYQKR PPPAWPHEGV IIFDNVNFMY SPGGPLVLKH LTALIKSQEK VGIVGRTGAG 1090 1100 1110 1120 1130 1140 KSSLISALFR LSEPEGKIWI DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE 1150 1160 1170 1180 1190 1200 HTDEELWNAL QEVQLKETIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILRKNQILII 1210 1220 1230 1240 1250 1260 DEATANVDPR TDELIQKKIR EKFAHCTVLT IAHRLNTIID SDKIMVLDSG RLKEYDEPYV 1270 1280 1290 1300 1310 1320 LLQNKESLFY KMVQQLGKAE AAALTETAKQ VYFKRNYPHI GHTDHMVTNT SNGQPSTLTI FETAL
	Isoform 2 [UniParc]. Checksum: 1B51AE7536A136E8	FASTA	1,278	144,201
	10 20 30 40 50 60 MLPVYQEVKP NPLQDANLCS RVFFWWLNPL FKIGHKRRLE EDDMYSVLPE DRSQHLGEEL 70 80 90 100 110 120 QGFWDKEVLR AENDAQKPSL TRAIIKCYWK SYLVLGIFTL IEESAKVIQP IFLGKIINYF 130 140 150 160 170 180 ENYDPMDSVA LNTAYAYATV LTFCTLILAI LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR 190 200 210 220 230 240 LSNMAMGKTT TGQIVNLLSN DVNKFDQVTV FLHFLWAGPL QAIAVTALLW MEIGISCLAG 250 260 270 280 290 300 MAVLIILLPL QSCFGKLFSS LRSKTATFTD ARIRTMNEVI TGIRIIKMYA WEKSFSNLIT 310 320 330 340 350 360 NLRKKEISKI LRSSCLRGMN LASFFSASKI IVFVTFTTYV LLGSVITASR VFVAVTLYGA 370 380 390 400 410 420 VRLTVTLFFP SAIERVSEAI VSIRRIQTFL LLDEISQRNR QLPSDGKKMV HVQDFTAFWD 430 440 450 460 470 480 KASETPTLQG LSFTVRPGEL LAVVGPVGAG KSSLLSAVLG ELAPSHGLVS VHGRIAYVSQ 490 500 510 520 530 540 QPWVFSGTLR SNILFGKKYE KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGTTLSGGQK 550 560 570 580 590 600 ARVNLARAVY QDADIYLLDD PLSAVDAEVS RHLFELCICQ ILHEKITILV THQLQYLKAA 610 620 630 640 650 660 SQILILKDGK MVQKGTYTEF LKSGIDFGSL LKKDNEESEQ PPVPGTPTLR NRTFSESSVW 670 680 690 700 710 720 SQQSSRPSLK DGALESQDVA YVLQDWWLSY WANKQSMLNV TVNGGGNVTE KLDLNWYLGI 730 740 750 760 770 780 YSGLTVATVL FGIARSLLVF YVLVNSSQTL HNKMFESILK APVLFFDRNP IGRILNRFSK 790 800 810 820 830 840 DIGHLDDLLP LTFLDFIQTL LQVVGVVSVA VAVIPWIAIP LVPLGIIFIF LRRYFLETSR 850 860 870 880 890 900 DVKRLESTTR SPVFSHLSSS LQGLWTIRAY KAEERCQELF DAHQDLHSEA WFLFLTTSRW 910 920 930 940 950 960 FAVRLDAICA MFVIIVAFGS LILAKTLDAG QVGLALSYAL TLMGMFQWCV RQSAEVENMM 970 980 990 1000 1010 1020 ISVERVIEYT DLEKEAPWEY QKRPPPAWPH EGVIIFDNVN FMYSPGGPLV LKHLTALIKS 1030 1040 1050 1060 1070 1080 QEKVGIVGRT GAGKSSLISA LFRLSEPEGK IWIDKILTTE IGLHDLRKKM SIIPQEPVLF 1090 1100 1110 1120 1130 1140 TGTMRKNLDP FNEHTDEELW NALQEVQLKE TIEDLPGKMD TELAESGSNF SVGQRQLVCL 1150 1160 1170 1180 1190 1200 ARAILRKNQI LIIDEATANV DPRTDELIQK KIREKFAHCT VLTIAHRLNT IIDSDKIMVL 1210 1220 1230 1240 1250 1260 DSGRLKEYDE PYVLLQNKES LFYKMVQQLG KAEAAALTET AKQVYFKRNY PHIGHTDHMV 1270 TNTSNGQPST LTIFETAL
	Isoform 3 [UniParc]. Checksum: A254809A2F5CE133	FASTA	859	96,841
	10 20 30 40 50 60 MLPVYQEVKP NPLQDANLCS RVFFWWLNPL FKIGHKRRLE EDDMYSVLPE DRSQHLGEEL 70 80 90 100 110 120 QGFWDKEVLR AENDAQKPSL TRAIIKCYWK SYLVLGIFTL IEESAKVIQP IFLGKIINYF 130 140 150 160 170 180 ENYDPMDSVA LNTAYAYATV LTFCTLILAI LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR 190 200 210 220 230 240 LSNMAMGKTT TGQIVNLLSN DVNKFDQVTV FLHFLWAGPL QAIAVTALLW MEIGISCLAG 250 260 270 280 290 300 MAVLIILLPL QSCFGKLFSS LRSKTATFTD ARIRTMNEVI TGIRIIKMYA WEKSFSNLIT 310 320 330 340 350 360 NLRKKEISKI LRSSCLRGMN LASFFSASKI IVFVTFTTYV LLGSVITASR VFVAVTLYGA 370 380 390 400 410 420 VRLTVTLFFP SAIERVSEAI VSIRRIQTFL LLDEISQRNR QLPSDGKKMV HVQDFTAFWD 430 440 450 460 470 480 KASETPTLQG LSFTVRPGEL LAVVGPVGAG KSSLLSAVLG ELAPSHGLVS VHGRIAYVSQ 490 500 510 520 530 540 QPWVFSGTLR SNILFGKKYE KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGTTLSGGQK 550 560 570 580 590 600 ARVNLARAVY QDADIYLLDD PLSAVDAEVS RHLFELCICQ ILHEKITILV THQLQYLKAA 610 620 630 640 650 660 SQILILKDGK MVQKGTYTEF LKSGIDFGSL LKKDNEESEQ PPVPGTPTLR NRTFSESSVW 670 680 690 700 710 720 SQQSSRPSLK DGALESQDTE NVPVTLSEEN RSEGKVGFQA YKNYFRAGAH WIVFIFLILL 730 740 750 760 770 780 NTAAQVAYVL QDWWLSYWAN KQSMLNVTVN GGGNVTEKLD LNWYLGIYSG LTVATVLFGI 790 800 810 820 830 840 ARSLLVFYVL VNSSQTLHNK MFESILKAPV LFFDRNPIGR ILNRFSKDIG HLDDLLPLTF 850 LDFIQRWDLA VLSWLVSNS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter." Lee K., Belinsky M.G., Bell D.W., Testa J.R., Kruh G.D. Cancer Res. 58:2741-2747(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-18.
[2]	"Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing." Adachi M., Sampath J., Lan L.B., Sun D., Hargrove P., Flatley R., Tatum A., Edwards M.Z., Wezeman M., Matherly L., Drake R., Schuetz J. J. Biol. Chem. 277:38998-39004(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-18.
[3]	Kato R., Ishikawa T. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Kidney.
[4]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[7]	"Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines." Kool M., de Haas M., Scheffer G.L., Scheper R.J., van Eijk M.J., Juijn J.A., Baas F., Borst P. Cancer Res. 57:3537-3547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1155-1316 (ISOFORMS 1/2). Tissue: Brain.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4." Janke D., Mehralivand S., Strand D., Goedtel-Armbrust U., Habermeier A., Gradhand U., Fischer C., Toliat M.R., Fritz P., Zanger U.M., Schwab M., Fromm M.F., Nuernberg P., Wojnowski L., Closs E.I., Lang T. Hum. Mutat. 29:659-669(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS CYS-556; ILE-776; ILE-820; PHE-854 AND VAL-866, CHARACTERIZATION OF VARIANTS TRP-187; ASN-304; GLU-487; CYS-556; LYS-757; ILE-776; ILE-820; PHE-854; VAL-866 AND MET-1142.
+	Additional computationally mapped references.

Web resources

ABCMdb

Database for mutations in ABC proteins

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF071202 mRNA. Translation: AAC27076.1. AY081219 mRNA. Translation: AAL88745.1. AY207008 mRNA. Translation: AAO37649.1. AF541977 mRNA. Translation: AAN17334.1. AL157818, AL139381, AL356257 Genomic DNA. Translation: CAC36037.2. AL139381, AL157818, AL356257 Genomic DNA. Translation: CAI16589.1. AL356257, AL139381, AL157818 Genomic DNA. Translation: CAI16722.1. AL359750 Genomic DNA. No translation available. CH471085 Genomic DNA. Translation: EAX08951.1. CH471085 Genomic DNA. Translation: EAX08950.1. BC041560 mRNA. Translation: AAH41560.1. U83660 mRNA. Translation: AAB71757.1.
IPI	IPI00006675. IPI00867698. IPI00908369.
RefSeq	NP_001098985.1. NM_001105515.1. NP_005836.2. NM_005845.3.
UniGene	Hs.508423.
3D structure databases
ProteinModelPortal	O15439.
ModBase	Search...
Protein-protein interaction databases
IntAct	O15439. 1 interaction.
STRING	9606.ENSP00000366084.
Protein family/group databases
TCDB	3.A.1.208.7. ATP-binding cassette (ABC) superfamily.
PTM databases
PhosphoSite	O15439.
Proteomic databases
PaxDb	O15439.
PRIDE	O15439.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376887; ENSP00000366084; ENSG00000125257. ENST00000412704; ENSP00000388657; ENSG00000125257. ENST00000431522; ENSP00000398562; ENSG00000125257.
GeneID	10257.
KEGG	hsa:10257.
UCSC	uc001vmd.4. human. uc001vme.2. human. uc010afk.3. human.
Organism-specific databases
CTD	10257.
GeneCards	GC13M095672.
HGNC	HGNC:55. ABCC4.
HPA	CAB002751. HPA002476.
MIM	605250. gene.
neXtProt	NX_O15439.
PharmGKB	PA397.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1132.
HOVERGEN	HBG108314.
InParanoid	O15439.
KO	K05673.
OMA	LTFCTLI.
OrthoDB	EOG476JZD.
PhylomeDB	O15439.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	O15439.
Bgee	O15439.
CleanEx	HS_ABCC4.
Genevestigator	O15439.
GermOnline	ENSG00000125257. Homo sapiens.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 2 hits. SSF52540. SSF52540. 2 hits.
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1743128.
DrugBank	DB01327. Cefazolin.
GenomeRNAi	10257.
NextBio	38868.
SOURCE	Search...

Entry information

Entry name

MRP4_HUMAN

Accession

Primary (citable) accession number: O15439
Secondary accession number(s): A9Z1Z7 , Q8IVZ4, Q8IZN6, Q8NEW8, Q9Y6J2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	September 23, 2008
Last modified:	May 29, 2013
This is version 127 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.