Canalicular multispecific organic anion transporter 2

Names and origin

Protein names

Recommended name:
    Canalicular multispecific organic anion transporter 2
Alternative name(s):
    ATP-binding cassette sub-family C member 3
    Multidrug resistance-associated protein 3
    Multi-specific organic anion transporter D
      Short name=MOAT-D

Gene names

Name:	ABCC3
Synonyms:	CMOAT2, MLP2, MRP3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1527 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.

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Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to plasma membrane Ref.3 Traceable author statement. Source: ProtInc membrane fraction Ref.3 Traceable author statement. Source: ProtInc
Molecular function	ATP binding Ref.3 Traceable author statement. Source: ProtInc ATPase activity, coupled to transmembrane movement of substances Ref.3 Traceable author statement. Source: ProtInc organic anion transmembrane transporter activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

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Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] Note: Additional isoforms seem to exist.

Isoform 3 (identifier: O15438-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 3A (identifier: O15438-2) The sequence of this isoform differs from the canonical sequence as follows: 1194-1527: WLSIGVEFVG...YGMARDAGLA → SEAASLAPCS...ALPLPHFLLI
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 3B (identifier: O15438-3) The sequence of this isoform differs from the canonical sequence as follows: 226-510: MAIYGYRHPL...LKLYAWEPSF → LLNPDPLRGC...IEGLAHQADE 511-1527: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 3S1 (identifier: O15438-4) The sequence of this isoform differs from the canonical sequence as follows: 1-1242: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1527

1527

Canalicular multispecific organic anion transporter 2

PRO_0000093360

Regions

Topological domain

1 – 32

32

Extracellular By similarity

Transmembrane

33 – 53

21

1 By similarity

Topological domain

54 – 73

20

Cytoplasmic By similarity

Transmembrane

74 – 94

21

2 By similarity

Topological domain

95 – 99

5

Extracellular By similarity

Transmembrane

100 – 120

21

3 By similarity

Topological domain

121 – 132

12

Cytoplasmic By similarity

Transmembrane

133 – 153

21

4 By similarity

Topological domain

154 – 171

18

Extracellular By similarity

Transmembrane

172 – 192

21

5 By similarity

Topological domain

193 – 302

110

Cytoplasmic By similarity

Transmembrane

303 – 323

21

6 By similarity

Topological domain

324 – 349

26

Extracellular By similarity

Transmembrane

350 – 370

21

7 By similarity

Topological domain

371 – 426

56

Cytoplasmic By similarity

Transmembrane

427 – 447

21

8 By similarity

Topological domain

448 – 450

3

Extracellular By similarity

Transmembrane

451 – 471

21

9 By similarity

Topological domain

472 – 533

62

Cytoplasmic By similarity

Transmembrane

534 – 554

21

10 By similarity

Topological domain

555 – 576

22

Extracellular By similarity

Transmembrane

577 – 597

21

11 By similarity

Topological domain

598 – 963

366

Cytoplasmic By similarity

Transmembrane

964 – 984

21

12 By similarity

Topological domain

985 – 1021

37

Extracellular By similarity

Transmembrane

1022 – 1042

21

13 By similarity

Topological domain

1043 – 1085

43

Cytoplasmic By similarity

Transmembrane

1086 – 1106

21

14 By similarity

Topological domain

1107

1

Extracellular By similarity

Transmembrane

1108 – 1128

21

15 By similarity

Topological domain

1129 – 1199

71

Cytoplasmic By similarity

Transmembrane

1200 – 1220

21

16 By similarity

Topological domain

1221 – 1222

2

Extracellular By similarity

Transmembrane

1223 – 1243

21

17 By similarity

Topological domain

1244 – 1527

284

Cytoplasmic By similarity

Domain

311 – 594

284

ABC transmembrane type-1 1

Domain

629 – 851

223

ABC transporter 1

Domain

971 – 1252

282

ABC transmembrane type-1 2

Domain

1291 – 1523

233

ABC transporter 2

Nucleotide binding

661 – 668

8

ATP 1 Potential

Nucleotide binding

1323 – 1330

8

ATP 2 Potential

Amino acid modifications

Modified residue

908

1

Phosphoserine By similarity

Glycosylation

18

1

N-linked (GlcNAc...) Potential

Glycosylation

1006

1

N-linked (GlcNAc...) Potential

Glycosylation

1007

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

1 – 1242

1242

Missing in isoform 3S1.

VSP_000043

Alternative sequence

226 – 510

285

MAIYG…WEPSF → LLNPDPLRGCLPGFTSPQDG HLWLPASPGGEGPLVPKGRG QIPDGGAAAAGGMEEAGKAD GTTQGFSSTWEKCLRRGRGA AGCPAQAPEALLPEGPAGHL RLQLPHQCLLQAYPGPALLH QSTAAQHPDQVYLQPHGPLL VGLPGGWADVPVLHDAVADL TTLLPLHLCDWGEVSYWDHG CHLQEGSGYHQLSQTCVHCG GNCQPHVSGCPALHGPCPLP QSAVVSTPADHPGDLLPLAE PRSLCPGWSRFHGLADSTQR SCGREDARLPGKANEIEGLA HQADE in isoform 3B.

VSP_000040

Alternative sequence

511 – 1527

1017

Missing in isoform 3B.

VSP_000041

Alternative sequence

1194 – 1527

334

WLSIG…DAGLA → SEAASLAPCSSRNSQQALWC SGSLSLLSPKQKTGPALPLP HFLLI in isoform 3A.

VSP_000042

Natural variant

11

1

G → D: dbSNP rs11568609.

VAR_029119

Natural variant

346

1

S → F: dbSNP rs11568605.

VAR_020235

Natural variant

1286

1

R → G: dbSNP rs11568593.

VAR_029120

Natural variant

1297

1

R → H: dbSNP rs11568591.

VAR_020237

Natural variant

1365

1

Q → R: dbSNP rs11568590.

VAR_020239

Natural variant

1381

1

R → S: dbSNP rs45461799.

VAR_020240

Experimental info

Sequence conflict

42

1

C → R in CAA76658. Ref.2

Sequence conflict

184

1

A → T in AAD02846. Ref.5

Sequence conflict

344

1

A → G in AAC34668. Ref.3

Sequence conflict

356 – 361

6

MFLCSM → DVPVAPW Ref.4

Sequence conflict

569

1

F → Y in BAA28146. Ref.1

Sequence conflict

1128

1

F → C in AAB71756. Ref.8

Sequence conflict

1212

1

L → I in AAB71756. Ref.8

Sequence conflict

1249

1

D → E in AAB71756. Ref.8

Sequence conflict

1335 – 1337

3

CLF → ACS in AAB71756. Ref.8

Sequence conflict

1359

1

L → F in AAB71756. Ref.8

Sequence conflict

1362 – 1366

5

LRSQL → VRCQM in AAB71756. Ref.8

Sequence conflict

1362

1

L → V in AAC34668. Ref.3

Sequence conflict

1371

1

Q → R in AAB71756. Ref.8

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Sequences

Sequence		Length	Mass (Da)
Isoform 3 [UniParc]. Last modified May 30, 2000. Version 3. Checksum: 0D1F879B6F18370C Show »	FASTA	1,527	169,343
10 20 30 40 50 60 MDALCGSGEL GSKFWDSNLS VHTENPDLTP CFQNSLLAWV PCIYLWVALP CYLLYLRHHC 70 80 90 100 110 120 RGYIILSHLS KLKMVLGVLL WCVSWADLFY SFHGLVHGRA PAPVFFVTPL VVGVTMLLAT 130 140 150 160 170 180 LLIQYERLQG VQSSGVLIIF WFLCVVCAIV PFRSKILLAK AEGEISDPFR FTTFYIHFAL 190 200 210 220 230 240 VLSALILACF REKPPFFSAK NVDPNPYPET SAGFLSRLFF WWFTKMAIYG YRHPLEEKDL 250 260 270 280 290 300 WSLKEEDRSQ MVVQQLLEAW RKQEKQTARH KASAAPGKNA SGEDEVLLGA RPRPRKPSFL 310 320 330 340 350 360 KALLATFGSS FLISACFKLI QDLLSFINPQ LLSILIRFIS NPMAPSWWGF LVAGLMFLCS 370 380 390 400 410 420 MMQSLILQHY YHYIFVTGVK FRTGIMGVIY RKALVITNSV KRASTVGEIV NLMSVDAQRF 430 440 450 460 470 480 MDLAPFLNLL WSAPLQIILA IYFLWQNLGP SVLAGVAFMV LLIPLNGAVA VKMRAFQVKQ 490 500 510 520 530 540 MKLKDSRIKL MSEILNGIKV LKLYAWEPSF LKQVEGIRQG ELQLLRTAAY LHTTTTFTWM 550 560 570 580 590 600 CSPFLVTLIT LWVYVYVDPN NVLDAEKAFV SVSLFNILRL PLNMLPQLIS NLTQASVSLK 610 620 630 640 650 660 RIQQFLSQEE LDPQSVERKT ISPGYAITIH SGTFTWAQDL PPTLHSLDIQ VPKGALVAVV 670 680 690 700 710 720 GPVGCGKSSL VSALLGEMEK LEGKVHMKGS VAYVPQQAWI QNCTLQENVL FGKALNPKRY 730 740 750 760 770 780 QQTLEACALL ADLEMLPGGD QTEIGEKGIN LSGGQRQRVS LARAVYSDAD IFLLDDPLSA 790 800 810 820 830 840 VDSHVAKHIF DHVIGPEGVL AGKTRVLVTH GISFLPQTDF IIVLADGQVS EMGPYPALLQ 850 860 870 880 890 900 RNGSFANFLC NYAPDEDQGH LEDSWTALEG AEDKEALLIE DTLSNHTDLT DNDPVTYVVQ 910 920 930 940 950 960 KQFMRQLSAL SSDGEGQGRP VPRRHLGPSE KVQVTEAKAD GALTQEEKAA IGTVELSVFW 970 980 990 1000 1010 1020 DYAKAVGLCT TLAICLLYVG QSAAAIGANV WLSAWTNDAM ADSRQNNTSL RLGVYAALGI 1030 1040 1050 1060 1070 1080 LQGFLVMLAA MAMAAGGIQA ARVLHQALLH NKIRSPQSFF DTTPSGRILN CFSKDIYVVD 1090 1100 1110 1120 1130 1140 EVLAPVILML LNSFFNAIST LVVIMASTPL FTVVILPLAV LYTLVQRFYA ATSRQLKRLE 1150 1160 1170 1180 1190 1200 SVSRSPIYSH FSETVTGASV IRAYNRSRDF EIISDTKVDA NQRSCYPYII SNRWLSIGVE 1210 1220 1230 1240 1250 1260 FVGNCVVLFA ALFAVIGRSS LNPGLVGLSV SYSLQVTFAL NWMIRMMSDL ESNIVAVERV 1270 1280 1290 1300 1310 1320 KEYSKTETEA PWVVEGSRPP EGWPPRGEVE FRNYSVRYRP GLDLVLRDLS LHVHGGEKVG 1330 1340 1350 1360 1370 1380 IVGRTGAGKS SMTLCLFRIL EAAKGEIRID GLNVADIGLH DLRSQLTIIP QDPILFSGTL 1390 1400 1410 1420 1430 1440 RMNLDPFGSY SEEDIWWALE LSHLHTFVSS QPAGLDFQCS EGGENLSVGQ RQLVCLARAL 1450 1460 1470 1480 1490 1500 LRKSRILVLD EATAAIDLET DNLIQATIRT QFDTCTVLTI AHRLNTIMDY TRVLVLDKGV 1510 1520 VAEFDSPANL IAARGIFYGM ARDAGLA « Hide
Isoform 3A. Checksum: 8E449E28F32BA882 Show »	FASTA	1,238	137,297
10 20 30 40 50 60 MDALCGSGEL GSKFWDSNLS VHTENPDLTP CFQNSLLAWV PCIYLWVALP CYLLYLRHHC 70 80 90 100 110 120 RGYIILSHLS KLKMVLGVLL WCVSWADLFY SFHGLVHGRA PAPVFFVTPL VVGVTMLLAT 130 140 150 160 170 180 LLIQYERLQG VQSSGVLIIF WFLCVVCAIV PFRSKILLAK AEGEISDPFR FTTFYIHFAL 190 200 210 220 230 240 VLSALILACF REKPPFFSAK NVDPNPYPET SAGFLSRLFF WWFTKMAIYG YRHPLEEKDL 250 260 270 280 290 300 WSLKEEDRSQ MVVQQLLEAW RKQEKQTARH KASAAPGKNA SGEDEVLLGA RPRPRKPSFL 310 320 330 340 350 360 KALLATFGSS FLISACFKLI QDLLSFINPQ LLSILIRFIS NPMAPSWWGF LVAGLMFLCS 370 380 390 400 410 420 MMQSLILQHY YHYIFVTGVK FRTGIMGVIY RKALVITNSV KRASTVGEIV NLMSVDAQRF 430 440 450 460 470 480 MDLAPFLNLL WSAPLQIILA IYFLWQNLGP SVLAGVAFMV LLIPLNGAVA VKMRAFQVKQ 490 500 510 520 530 540 MKLKDSRIKL MSEILNGIKV LKLYAWEPSF LKQVEGIRQG ELQLLRTAAY LHTTTTFTWM 550 560 570 580 590 600 CSPFLVTLIT LWVYVYVDPN NVLDAEKAFV SVSLFNILRL PLNMLPQLIS NLTQASVSLK 610 620 630 640 650 660 RIQQFLSQEE LDPQSVERKT ISPGYAITIH SGTFTWAQDL PPTLHSLDIQ VPKGALVAVV 670 680 690 700 710 720 GPVGCGKSSL VSALLGEMEK LEGKVHMKGS VAYVPQQAWI QNCTLQENVL FGKALNPKRY 730 740 750 760 770 780 QQTLEACALL ADLEMLPGGD QTEIGEKGIN LSGGQRQRVS LARAVYSDAD IFLLDDPLSA 790 800 810 820 830 840 VDSHVAKHIF DHVIGPEGVL AGKTRVLVTH GISFLPQTDF IIVLADGQVS EMGPYPALLQ 850 860 870 880 890 900 RNGSFANFLC NYAPDEDQGH LEDSWTALEG AEDKEALLIE DTLSNHTDLT DNDPVTYVVQ 910 920 930 940 950 960 KQFMRQLSAL SSDGEGQGRP VPRRHLGPSE KVQVTEAKAD GALTQEEKAA IGTVELSVFW 970 980 990 1000 1010 1020 DYAKAVGLCT TLAICLLYVG QSAAAIGANV WLSAWTNDAM ADSRQNNTSL RLGVYAALGI 1030 1040 1050 1060 1070 1080 LQGFLVMLAA MAMAAGGIQA ARVLHQALLH NKIRSPQSFF DTTPSGRILN CFSKDIYVVD 1090 1100 1110 1120 1130 1140 EVLAPVILML LNSFFNAIST LVVIMASTPL FTVVILPLAV LYTLVQRFYA ATSRQLKRLE 1150 1160 1170 1180 1190 1200 SVSRSPIYSH FSETVTGASV IRAYNRSRDF EIISDTKVDA NQRSCYPYII SNRSEAASLA 1210 1220 1230 PCSSRNSQQA LWCSGSLSLL SPKQKTGPAL PLPHFLLI « Hide
Isoform 3B. Checksum: B00B65CBB262DEAA Show »	FASTA	510	55,305
10 20 30 40 50 60 MDALCGSGEL GSKFWDSNLS VHTENPDLTP CFQNSLLAWV PCIYLWVALP CYLLYLRHHC 70 80 90 100 110 120 RGYIILSHLS KLKMVLGVLL WCVSWADLFY SFHGLVHGRA PAPVFFVTPL VVGVTMLLAT 130 140 150 160 170 180 LLIQYERLQG VQSSGVLIIF WFLCVVCAIV PFRSKILLAK AEGEISDPFR FTTFYIHFAL 190 200 210 220 230 240 VLSALILACF REKPPFFSAK NVDPNPYPET SAGFLSRLFF WWFTKLLNPD PLRGCLPGFT 250 260 270 280 290 300 SPQDGHLWLP ASPGGEGPLV PKGRGQIPDG GAAAAGGMEE AGKADGTTQG FSSTWEKCLR 310 320 330 340 350 360 RGRGAAGCPA QAPEALLPEG PAGHLRLQLP HQCLLQAYPG PALLHQSTAA QHPDQVYLQP 370 380 390 400 410 420 HGPLLVGLPG GWADVPVLHD AVADLTTLLP LHLCDWGEVS YWDHGCHLQE GSGYHQLSQT 430 440 450 460 470 480 CVHCGGNCQP HVSGCPALHG PCPLPQSAVV STPADHPGDL LPLAEPRSLC PGWSRFHGLA 490 500 510 DSTQRSCGRE DARLPGKANE IEGLAHQADE « Hide
Isoform 3S1. Checksum: F8FA212E645D7CF7 Show »	FASTA	285	31,554
10 20 30 40 50 60 MIRMMSDLES NIVAVERVKE YSKTETEAPW VVEGSRPPEG WPPRGEVEFR NYSVRYRPGL 70 80 90 100 110 120 DLVLRDLSLH VHGGEKVGIV GRTGAGKSSM TLCLFRILEA AKGEIRIDGL NVADIGLHDL 130 140 150 160 170 180 RSQLTIIPQD PILFSGTLRM NLDPFGSYSE EDIWWALELS HLHTFVSSQP AGLDFQCSEG 190 200 210 220 230 240 GENLSVGQRQ LVCLARALLR KSRILVLDEA TAAIDLETDN LIQATIRTQF DTCTVLTIAH 250 260 270 280 RLNTIMDYTR VLVLDKGVVA EFDSPANLIA ARGIFYGMAR DAGLA « Hide

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References

[1]	"cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)." Kiuchi Y., Suzuki H., Hirohashi T., Tyson C.A., Sugiyama Y. FEBS Lett. 433:149-152(1998) [PubMed: 9738950] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane." Koenig J., Rost D., Cui Y., Keppler D. Hepatology 29:1156-1163(1999) [PubMed: 10094960] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[3]	"Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport." Uchiumi T., Hinoshita E., Haga S., Nakamura T., Tanaka T., Toh S., Furukawa M., Kawabe T., Wada M., Kagotani K., Okumura K., Kohno K., Akiyama S., Kuwano M. Biochem. Biophys. Res. Commun. 252:103-110(1998) [PubMed: 9813153] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[4]	"Complete coding sequence of human MRP3, a homolog of the human multidrug resistance-associated protein MRP1." Kool M., de Haas M., Ponne N.J., Baas F., Borst P. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[5]	"Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants." Fromm M.F., Leake B., Roden D.M., Wilkinson G.R., Kim R.B. Biochim. Biophys. Acta 1415:369-374(1999) [PubMed: 9889399] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3A AND 3B). Tissue: Liver.
[6]	"Identification of a novel splice variant of MRP3 involved in resistance to DNA damaging agents." Auclair D., Alonso E., Chen L.B. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3S1). Tissue: Colon carcinoma.
[7]	"Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins." Belinsky M.G., Bain L.J., Balsara B.B., Testa J.R., Kruh G.D. J. Natl. Cancer Inst. 90:1735-1741(1998) [PubMed: 9827529] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[8]	"Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines." Kool M., de Haas M., Scheffer G.L., Scheper R.J., van Eijk M.J., Juijn J.A., Baas F., Borst P. Cancer Res. 57:3537-3547(1997) [PubMed: 9270026] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1043-1527. Tissue: Liver.
[9]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed: 14759258] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	AB010887 mRNA. Translation: BAA28146.1. Y17151 mRNA. Translation: CAA76658.2. AF083552 mRNA. Translation: AAC34668.1. AF009670 mRNA. Translation: AAD01430.1. AF085690 mRNA. Translation: AAD02845.1. AF085691 mRNA. Translation: AAD02846.1. AF085692 mRNA. Translation: AAD02847.1. AF154001 mRNA. Translation: AAD38185.1. AF104943 mRNA. Translation: AAD04170.1. U83659 mRNA. Translation: AAB71756.1.
IPI	IPI00006674. IPI00219843. IPI00219844. IPI00251066.
PIR	JE0336.
RefSeq	NP_003777.2.
UniGene	Hs.463421
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O15438.
Protein family/group databases
TCDB	3.A.1.208.9. ATP-binding cassette (ABC) superfamily.
PTM databases
PhosphoSite	O15438.
Proteomic databases
PRIDE	O15438.
Genome annotation databases
Ensembl	ENST00000285238; ENSP00000285238; ENSG00000108846; Homo sapiens. [Genome view]
GeneID	8714.
UCSC	uc002isl.1. human. uc002isn.1. human.
Organism-specific databases
CTD	8714.
GeneCards	GC17P046067.
H-InvDB	HIX0027109.
HGNC	HGNC:54. ABCC3.
MIM	604323. gene.
PharmGKB	PA376.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O15438.
OMA	FREKPPF
OrthoDB	EOG9SJ80K
Enzyme and pathway databases
Reactome	REACT_602. Metabolism of lipids and lipoproteins.
Gene expression databases
ArrayExpress	O15438.
Bgee	O15438.
CleanEx	HS_ABCC3.
Genevestigator	O15438.
GermOnline	ENSG00000108846. Homo sapiens.
Family and domain databases
InterPro	IPR011527. ABC_TM_1. IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. IPR005292. Multidrug-R_assoc. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
TIGRFAMs	TIGR00957. MRP_assoc_pro. 1 hit.
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB01016. Glibenclamide.
NextBio	32679.
SOURCE	Search...

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Entry information

Entry name

MRP3_HUMAN

Accession

Primary (citable) accession number: O15438
Secondary accession number(s): O60265

Q9UN52

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 30, 2000
Last modified:	November 24, 2009
This is version 95 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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List of human entries with polymorphisms or disease mutations

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Index of human polymorphisms and disease mutations

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Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents