O15438 (MRP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Canalicular multispecific organic anion transporter 2

Alternative name(s):
ATP-binding cassette sub-family C member 3
Multi-specific organic anion transporter D
Short name=MOAT-D
Multidrug resistance-associated protein 3

Gene names

Name:	ABCC3
Synonyms:	CMOAT2, MLP2, MRP3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1527 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.
Sequence caution	The sequence AAB71756.1 differs from that shown. Reason: Frameshift at positions 1334 and 1338. The sequence AAD01430.1 differs from that shown. Reason: Frameshift at positions 355, 359 and 361. The sequence AAD38185.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bile acid and bile salt transport Traceable author statement. Source: Reactome bile acid metabolic process Traceable author statement. Source: Reactome
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	ATP binding Traceable author statement Ref.1. Source: ProtInc ATPase activity, coupled to transmembrane movement of substances Traceable author statement Ref.1. Source: ProtInc organic anion transmembrane transporter activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: O15438-1)

Also known as: MRP3;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O15438-2)

Also known as: MRP3A;

The sequence of this isoform differs from the canonical sequence as follows:
     1194-1527: WLSIGVEFVG...YGMARDAGLA → SEAASLAPCS...ALPLPHFLLI

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 3 (identifier: O15438-3)

Also known as: MRP3B;

The sequence of this isoform differs from the canonical sequence as follows:
     226-510: MAIYGYRHPL...LKLYAWEPSF → LLNPDPLRGC...IEGLAHQADE
     511-1527: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 4 (identifier: O15438-4)

Also known as: MRP3S1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPACTVKESPNCKRNFCKADHIVNTSGGSNLERVGKQKTIQKGQFSQRSVCT

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Isoform 5 (identifier: O15438-5)

The sequence of this isoform differs from the canonical sequence as follows:
     547-572: TLITLWVYVYVDPNNVLDAEKAFVSV → RLGTGLGPCLQGSGCPGMARAHWTLP
     573-1527: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1527	1527	Canalicular multispecific organic anion transporter 2		PRO_0000093360
Regions
	Topological domain	1 – 32	32	Extracellular By similarity
	Transmembrane	33 – 53	21	Helical; Name=1; By similarity
	Topological domain	54 – 73	20	Cytoplasmic By similarity
	Transmembrane	74 – 94	21	Helical; Name=2; By similarity
	Topological domain	95 – 99	5	Extracellular By similarity
	Transmembrane	100 – 120	21	Helical; Name=3; By similarity
	Topological domain	121 – 132	12	Cytoplasmic By similarity
	Transmembrane	133 – 153	21	Helical; Name=4; By similarity
	Topological domain	154 – 171	18	Extracellular By similarity
	Transmembrane	172 – 192	21	Helical; Name=5; By similarity
	Topological domain	193 – 302	110	Cytoplasmic By similarity
	Transmembrane	303 – 323	21	Helical; Name=6; By similarity
	Topological domain	324 – 349	26	Extracellular By similarity
	Transmembrane	350 – 370	21	Helical; Name=7; By similarity
	Topological domain	371 – 426	56	Cytoplasmic By similarity
	Transmembrane	427 – 447	21	Helical; Name=8; By similarity
	Topological domain	448 – 450	3	Extracellular By similarity
	Transmembrane	451 – 471	21	Helical; Name=9; By similarity
	Topological domain	472 – 533	62	Cytoplasmic By similarity
	Transmembrane	534 – 554	21	Helical; Name=10; By similarity
	Topological domain	555 – 576	22	Extracellular By similarity
	Transmembrane	577 – 597	21	Helical; Name=11; By similarity
	Topological domain	598 – 963	366	Cytoplasmic By similarity
	Transmembrane	964 – 984	21	Helical; Name=12; By similarity
	Topological domain	985 – 1021	37	Extracellular By similarity
	Transmembrane	1022 – 1042	21	Helical; Name=13; By similarity
	Topological domain	1043 – 1085	43	Cytoplasmic By similarity
	Transmembrane	1086 – 1106	21	Helical; Name=14; By similarity
	Topological domain	1107	1	Extracellular By similarity
	Transmembrane	1108 – 1128	21	Helical; Name=15; By similarity
	Topological domain	1129 – 1199	71	Cytoplasmic By similarity
	Transmembrane	1200 – 1220	21	Helical; Name=16; By similarity
	Topological domain	1221 – 1222	2	Extracellular By similarity
	Transmembrane	1223 – 1243	21	Helical; Name=17; By similarity
	Topological domain	1244 – 1527	284	Cytoplasmic By similarity
	Domain	311 – 594	284	ABC transmembrane type-1 1
	Domain	629 – 851	223	ABC transporter 1
	Domain	971 – 1252	282	ABC transmembrane type-1 2
	Domain	1291 – 1523	233	ABC transporter 2
	Nucleotide binding	661 – 668	8	ATP 1 Potential
	Nucleotide binding	1323 – 1330	8	ATP 2 Potential
Amino acid modifications
	Modified residue	908	1	Phosphoserine By similarity
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Glycosylation	1006	1	N-linked (GlcNAc...) Potential
	Glycosylation	1007	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1	1	M → MPACTVKESPNCKRNFCKAD HIVNTSGGSNLERVGKQKTI QKGQFSQRSVCT in isoform 4.		VSP_043864
	Alternative sequence	226 – 510	285	MAIYG…WEPSF → LLNPDPLRGCLPGFTSPQDG HLWLPASPGGEGPLVPKGRG QIPDGGAAAAGGMEEAGKAD GTTQGFSSTWEKCLRRGRGA AGCPAQAPEALLPEGPAGHL RLQLPHQCLLQAYPGPALLH QSTAAQHPDQVYLQPHGPLL VGLPGGWADVPVLHDAVADL TTLLPLHLCDWGEVSYWDHG CHLQEGSGYHQLSQTCVHCG GNCQPHVSGCPALHGPCPLP QSAVVSTPADHPGDLLPLAE PRSLCPGWSRFHGLADSTQR SCGREDARLPGKANEIEGLA HQADE in isoform 3.		VSP_000040
	Alternative sequence	511 – 1527	1017	Missing in isoform 3.		VSP_000041
	Alternative sequence	547 – 572	26	TLITL…AFVSV → RLGTGLGPCLQGSGCPGMAR AHWTLP in isoform 5.		VSP_039041
	Alternative sequence	573 – 1527	955	Missing in isoform 5.		VSP_039042
	Alternative sequence	1194 – 1527	334	WLSIG…DAGLA → SEAASLAPCSSRNSQQALWC SGSLSLLSPKQKTGPALPLP HFLLI in isoform 2.		VSP_000042
	Natural variant	11	1	G → D. Corresponds to variant rs11568609 [ dbSNP | Ensembl ].		VAR_029119
	Natural variant	346	1	S → F. Corresponds to variant rs11568605 [ dbSNP | Ensembl ].		VAR_020235
	Natural variant	1286	1	R → G. Corresponds to variant rs11568593 [ dbSNP | Ensembl ].		VAR_029120
	Natural variant	1297	1	R → H. Corresponds to variant rs11568591 [ dbSNP | Ensembl ].		VAR_020237
	Natural variant	1365	1	Q → R. Corresponds to variant rs11568590 [ dbSNP | Ensembl ].		VAR_020239
	Natural variant	1381	1	R → S. Corresponds to variant rs45461799 [ dbSNP | Ensembl ].		VAR_020240
Experimental info
	Sequence conflict	13	1	K → N in AAH46126. Ref.10
	Sequence conflict	42	1	C → R in CAA76658. Ref.5
	Sequence conflict	184	1	A → T in AAD02846. Ref.4
	Sequence conflict	344	1	A → G in AAC34668. Ref.1
	Sequence conflict	569	1	F → Y in BAA28146. Ref.2
	Sequence conflict	1128	1	F → C in AAB71756. Ref.11
	Sequence conflict	1212	1	L → I in AAB71756. Ref.11
	Sequence conflict	1249	1	D → E in AAB71756. Ref.11
	Sequence conflict	1359	1	L → F in AAB71756. Ref.11
	Sequence conflict	1362	1	L → V in AAC34668. Ref.1
	Sequence conflict	1362	1	L → V in AAB71756. Ref.11
	Sequence conflict	1364	1	S → C in AAB71756. Ref.11
	Sequence conflict	1366	1	L → M in AAB71756. Ref.11
	Sequence conflict	1371	1	Q → R in AAB71756. Ref.11

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (MRP3) [UniParc]. Last modified May 30, 2000. Version 3. Checksum: 0D1F879B6F18370C	FASTA	1,527	169,343
	10 20 30 40 50 60 MDALCGSGEL GSKFWDSNLS VHTENPDLTP CFQNSLLAWV PCIYLWVALP CYLLYLRHHC 70 80 90 100 110 120 RGYIILSHLS KLKMVLGVLL WCVSWADLFY SFHGLVHGRA PAPVFFVTPL VVGVTMLLAT 130 140 150 160 170 180 LLIQYERLQG VQSSGVLIIF WFLCVVCAIV PFRSKILLAK AEGEISDPFR FTTFYIHFAL 190 200 210 220 230 240 VLSALILACF REKPPFFSAK NVDPNPYPET SAGFLSRLFF WWFTKMAIYG YRHPLEEKDL 250 260 270 280 290 300 WSLKEEDRSQ MVVQQLLEAW RKQEKQTARH KASAAPGKNA SGEDEVLLGA RPRPRKPSFL 310 320 330 340 350 360 KALLATFGSS FLISACFKLI QDLLSFINPQ LLSILIRFIS NPMAPSWWGF LVAGLMFLCS 370 380 390 400 410 420 MMQSLILQHY YHYIFVTGVK FRTGIMGVIY RKALVITNSV KRASTVGEIV NLMSVDAQRF 430 440 450 460 470 480 MDLAPFLNLL WSAPLQIILA IYFLWQNLGP SVLAGVAFMV LLIPLNGAVA VKMRAFQVKQ 490 500 510 520 530 540 MKLKDSRIKL MSEILNGIKV LKLYAWEPSF LKQVEGIRQG ELQLLRTAAY LHTTTTFTWM 550 560 570 580 590 600 CSPFLVTLIT LWVYVYVDPN NVLDAEKAFV SVSLFNILRL PLNMLPQLIS NLTQASVSLK 610 620 630 640 650 660 RIQQFLSQEE LDPQSVERKT ISPGYAITIH SGTFTWAQDL PPTLHSLDIQ VPKGALVAVV 670 680 690 700 710 720 GPVGCGKSSL VSALLGEMEK LEGKVHMKGS VAYVPQQAWI QNCTLQENVL FGKALNPKRY 730 740 750 760 770 780 QQTLEACALL ADLEMLPGGD QTEIGEKGIN LSGGQRQRVS LARAVYSDAD IFLLDDPLSA 790 800 810 820 830 840 VDSHVAKHIF DHVIGPEGVL AGKTRVLVTH GISFLPQTDF IIVLADGQVS EMGPYPALLQ 850 860 870 880 890 900 RNGSFANFLC NYAPDEDQGH LEDSWTALEG AEDKEALLIE DTLSNHTDLT DNDPVTYVVQ 910 920 930 940 950 960 KQFMRQLSAL SSDGEGQGRP VPRRHLGPSE KVQVTEAKAD GALTQEEKAA IGTVELSVFW 970 980 990 1000 1010 1020 DYAKAVGLCT TLAICLLYVG QSAAAIGANV WLSAWTNDAM ADSRQNNTSL RLGVYAALGI 1030 1040 1050 1060 1070 1080 LQGFLVMLAA MAMAAGGIQA ARVLHQALLH NKIRSPQSFF DTTPSGRILN CFSKDIYVVD 1090 1100 1110 1120 1130 1140 EVLAPVILML LNSFFNAIST LVVIMASTPL FTVVILPLAV LYTLVQRFYA ATSRQLKRLE 1150 1160 1170 1180 1190 1200 SVSRSPIYSH FSETVTGASV IRAYNRSRDF EIISDTKVDA NQRSCYPYII SNRWLSIGVE 1210 1220 1230 1240 1250 1260 FVGNCVVLFA ALFAVIGRSS LNPGLVGLSV SYSLQVTFAL NWMIRMMSDL ESNIVAVERV 1270 1280 1290 1300 1310 1320 KEYSKTETEA PWVVEGSRPP EGWPPRGEVE FRNYSVRYRP GLDLVLRDLS LHVHGGEKVG 1330 1340 1350 1360 1370 1380 IVGRTGAGKS SMTLCLFRIL EAAKGEIRID GLNVADIGLH DLRSQLTIIP QDPILFSGTL 1390 1400 1410 1420 1430 1440 RMNLDPFGSY SEEDIWWALE LSHLHTFVSS QPAGLDFQCS EGGENLSVGQ RQLVCLARAL 1450 1460 1470 1480 1490 1500 LRKSRILVLD EATAAIDLET DNLIQATIRT QFDTCTVLTI AHRLNTIMDY TRVLVLDKGV 1510 1520 VAEFDSPANL IAARGIFYGM ARDAGLA
	Isoform 2 (MRP3A) [UniParc]. Checksum: 8E449E28F32BA882	FASTA	1,238	137,297
	10 20 30 40 50 60 MDALCGSGEL GSKFWDSNLS VHTENPDLTP CFQNSLLAWV PCIYLWVALP CYLLYLRHHC 70 80 90 100 110 120 RGYIILSHLS KLKMVLGVLL WCVSWADLFY SFHGLVHGRA PAPVFFVTPL VVGVTMLLAT 130 140 150 160 170 180 LLIQYERLQG VQSSGVLIIF WFLCVVCAIV PFRSKILLAK AEGEISDPFR FTTFYIHFAL 190 200 210 220 230 240 VLSALILACF REKPPFFSAK NVDPNPYPET SAGFLSRLFF WWFTKMAIYG YRHPLEEKDL 250 260 270 280 290 300 WSLKEEDRSQ MVVQQLLEAW RKQEKQTARH KASAAPGKNA SGEDEVLLGA RPRPRKPSFL 310 320 330 340 350 360 KALLATFGSS FLISACFKLI QDLLSFINPQ LLSILIRFIS NPMAPSWWGF LVAGLMFLCS 370 380 390 400 410 420 MMQSLILQHY YHYIFVTGVK FRTGIMGVIY RKALVITNSV KRASTVGEIV NLMSVDAQRF 430 440 450 460 470 480 MDLAPFLNLL WSAPLQIILA IYFLWQNLGP SVLAGVAFMV LLIPLNGAVA VKMRAFQVKQ 490 500 510 520 530 540 MKLKDSRIKL MSEILNGIKV LKLYAWEPSF LKQVEGIRQG ELQLLRTAAY LHTTTTFTWM 550 560 570 580 590 600 CSPFLVTLIT LWVYVYVDPN NVLDAEKAFV SVSLFNILRL PLNMLPQLIS NLTQASVSLK 610 620 630 640 650 660 RIQQFLSQEE LDPQSVERKT ISPGYAITIH SGTFTWAQDL PPTLHSLDIQ VPKGALVAVV 670 680 690 700 710 720 GPVGCGKSSL VSALLGEMEK LEGKVHMKGS VAYVPQQAWI QNCTLQENVL FGKALNPKRY 730 740 750 760 770 780 QQTLEACALL ADLEMLPGGD QTEIGEKGIN LSGGQRQRVS LARAVYSDAD IFLLDDPLSA 790 800 810 820 830 840 VDSHVAKHIF DHVIGPEGVL AGKTRVLVTH GISFLPQTDF IIVLADGQVS EMGPYPALLQ 850 860 870 880 890 900 RNGSFANFLC NYAPDEDQGH LEDSWTALEG AEDKEALLIE DTLSNHTDLT DNDPVTYVVQ 910 920 930 940 950 960 KQFMRQLSAL SSDGEGQGRP VPRRHLGPSE KVQVTEAKAD GALTQEEKAA IGTVELSVFW 970 980 990 1000 1010 1020 DYAKAVGLCT TLAICLLYVG QSAAAIGANV WLSAWTNDAM ADSRQNNTSL RLGVYAALGI 1030 1040 1050 1060 1070 1080 LQGFLVMLAA MAMAAGGIQA ARVLHQALLH NKIRSPQSFF DTTPSGRILN CFSKDIYVVD 1090 1100 1110 1120 1130 1140 EVLAPVILML LNSFFNAIST LVVIMASTPL FTVVILPLAV LYTLVQRFYA ATSRQLKRLE 1150 1160 1170 1180 1190 1200 SVSRSPIYSH FSETVTGASV IRAYNRSRDF EIISDTKVDA NQRSCYPYII SNRSEAASLA 1210 1220 1230 PCSSRNSQQA LWCSGSLSLL SPKQKTGPAL PLPHFLLI
	Isoform 3 (MRP3B) [UniParc]. Checksum: B00B65CBB262DEAA	FASTA	510	55,305
	10 20 30 40 50 60 MDALCGSGEL GSKFWDSNLS VHTENPDLTP CFQNSLLAWV PCIYLWVALP CYLLYLRHHC 70 80 90 100 110 120 RGYIILSHLS KLKMVLGVLL WCVSWADLFY SFHGLVHGRA PAPVFFVTPL VVGVTMLLAT 130 140 150 160 170 180 LLIQYERLQG VQSSGVLIIF WFLCVVCAIV PFRSKILLAK AEGEISDPFR FTTFYIHFAL 190 200 210 220 230 240 VLSALILACF REKPPFFSAK NVDPNPYPET SAGFLSRLFF WWFTKLLNPD PLRGCLPGFT 250 260 270 280 290 300 SPQDGHLWLP ASPGGEGPLV PKGRGQIPDG GAAAAGGMEE AGKADGTTQG FSSTWEKCLR 310 320 330 340 350 360 RGRGAAGCPA QAPEALLPEG PAGHLRLQLP HQCLLQAYPG PALLHQSTAA QHPDQVYLQP 370 380 390 400 410 420 HGPLLVGLPG GWADVPVLHD AVADLTTLLP LHLCDWGEVS YWDHGCHLQE GSGYHQLSQT 430 440 450 460 470 480 CVHCGGNCQP HVSGCPALHG PCPLPQSAVV STPADHPGDL LPLAEPRSLC PGWSRFHGLA 490 500 510 DSTQRSCGRE DARLPGKANE IEGLAHQADE
	Isoform 4 (MRP3S1) [UniParc]. Checksum: 79A1F68027EBE525	FASTA	1,578	174,907
	10 20 30 40 50 60 MPACTVKESP NCKRNFCKAD HIVNTSGGSN LERVGKQKTI QKGQFSQRSV CTDALCGSGE 70 80 90 100 110 120 LGSKFWDSNL SVHTENPDLT PCFQNSLLAW VPCIYLWVAL PCYLLYLRHH CRGYIILSHL 130 140 150 160 170 180 SKLKMVLGVL LWCVSWADLF YSFHGLVHGR APAPVFFVTP LVVGVTMLLA TLLIQYERLQ 190 200 210 220 230 240 GVQSSGVLII FWFLCVVCAI VPFRSKILLA KAEGEISDPF RFTTFYIHFA LVLSALILAC 250 260 270 280 290 300 FREKPPFFSA KNVDPNPYPE TSAGFLSRLF FWWFTKMAIY GYRHPLEEKD LWSLKEEDRS 310 320 330 340 350 360 QMVVQQLLEA WRKQEKQTAR HKASAAPGKN ASGEDEVLLG ARPRPRKPSF LKALLATFGS 370 380 390 400 410 420 SFLISACFKL IQDLLSFINP QLLSILIRFI SNPMAPSWWG FLVAGLMFLC SMMQSLILQH 430 440 450 460 470 480 YYHYIFVTGV KFRTGIMGVI YRKALVITNS VKRASTVGEI VNLMSVDAQR FMDLAPFLNL 490 500 510 520 530 540 LWSAPLQIIL AIYFLWQNLG PSVLAGVAFM VLLIPLNGAV AVKMRAFQVK QMKLKDSRIK 550 560 570 580 590 600 LMSEILNGIK VLKLYAWEPS FLKQVEGIRQ GELQLLRTAA YLHTTTTFTW MCSPFLVTLI 610 620 630 640 650 660 TLWVYVYVDP NNVLDAEKAF VSVSLFNILR LPLNMLPQLI SNLTQASVSL KRIQQFLSQE 670 680 690 700 710 720 ELDPQSVERK TISPGYAITI HSGTFTWAQD LPPTLHSLDI QVPKGALVAV VGPVGCGKSS 730 740 750 760 770 780 LVSALLGEME KLEGKVHMKG SVAYVPQQAW IQNCTLQENV LFGKALNPKR YQQTLEACAL 790 800 810 820 830 840 LADLEMLPGG DQTEIGEKGI NLSGGQRQRV SLARAVYSDA DIFLLDDPLS AVDSHVAKHI 850 860 870 880 890 900 FDHVIGPEGV LAGKTRVLVT HGISFLPQTD FIIVLADGQV SEMGPYPALL QRNGSFANFL 910 920 930 940 950 960 CNYAPDEDQG HLEDSWTALE GAEDKEALLI EDTLSNHTDL TDNDPVTYVV QKQFMRQLSA 970 980 990 1000 1010 1020 LSSDGEGQGR PVPRRHLGPS EKVQVTEAKA DGALTQEEKA AIGTVELSVF WDYAKAVGLC 1030 1040 1050 1060 1070 1080 TTLAICLLYV GQSAAAIGAN VWLSAWTNDA MADSRQNNTS LRLGVYAALG ILQGFLVMLA 1090 1100 1110 1120 1130 1140 AMAMAAGGIQ AARVLHQALL HNKIRSPQSF FDTTPSGRIL NCFSKDIYVV DEVLAPVILM 1150 1160 1170 1180 1190 1200 LLNSFFNAIS TLVVIMASTP LFTVVILPLA VLYTLVQRFY AATSRQLKRL ESVSRSPIYS 1210 1220 1230 1240 1250 1260 HFSETVTGAS VIRAYNRSRD FEIISDTKVD ANQRSCYPYI ISNRWLSIGV EFVGNCVVLF 1270 1280 1290 1300 1310 1320 AALFAVIGRS SLNPGLVGLS VSYSLQVTFA LNWMIRMMSD LESNIVAVER VKEYSKTETE 1330 1340 1350 1360 1370 1380 APWVVEGSRP PEGWPPRGEV EFRNYSVRYR PGLDLVLRDL SLHVHGGEKV GIVGRTGAGK 1390 1400 1410 1420 1430 1440 SSMTLCLFRI LEAAKGEIRI DGLNVADIGL HDLRSQLTII PQDPILFSGT LRMNLDPFGS 1450 1460 1470 1480 1490 1500 YSEEDIWWAL ELSHLHTFVS SQPAGLDFQC SEGGENLSVG QRQLVCLARA LLRKSRILVL 1510 1520 1530 1540 1550 1560 DEATAAIDLE TDNLIQATIR TQFDTCTVLT IAHRLNTIMD YTRVLVLDKG VVAEFDSPAN 1570 LIAARGIFYG MARDAGLA
	Isoform 5 [UniParc]. Checksum: D50802109C86F4DE	FASTA	572	64,632
	10 20 30 40 50 60 MDALCGSGEL GSKFWDSNLS VHTENPDLTP CFQNSLLAWV PCIYLWVALP CYLLYLRHHC 70 80 90 100 110 120 RGYIILSHLS KLKMVLGVLL WCVSWADLFY SFHGLVHGRA PAPVFFVTPL VVGVTMLLAT 130 140 150 160 170 180 LLIQYERLQG VQSSGVLIIF WFLCVVCAIV PFRSKILLAK AEGEISDPFR FTTFYIHFAL 190 200 210 220 230 240 VLSALILACF REKPPFFSAK NVDPNPYPET SAGFLSRLFF WWFTKMAIYG YRHPLEEKDL 250 260 270 280 290 300 WSLKEEDRSQ MVVQQLLEAW RKQEKQTARH KASAAPGKNA SGEDEVLLGA RPRPRKPSFL 310 320 330 340 350 360 KALLATFGSS FLISACFKLI QDLLSFINPQ LLSILIRFIS NPMAPSWWGF LVAGLMFLCS 370 380 390 400 410 420 MMQSLILQHY YHYIFVTGVK FRTGIMGVIY RKALVITNSV KRASTVGEIV NLMSVDAQRF 430 440 450 460 470 480 MDLAPFLNLL WSAPLQIILA IYFLWQNLGP SVLAGVAFMV LLIPLNGAVA VKMRAFQVKQ 490 500 510 520 530 540 MKLKDSRIKL MSEILNGIKV LKLYAWEPSF LKQVEGIRQG ELQLLRTAAY LHTTTTFTWM 550 560 570 CSPFLVRLGT GLGPCLQGSG CPGMARAHWT LP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport." Uchiumi T., Hinoshita E., Haga S., Nakamura T., Tanaka T., Toh S., Furukawa M., Kawabe T., Wada M., Kagotani K., Okumura K., Kohno K., Akiyama S., Kuwano M. Biochem. Biophys. Res. Commun. 252:103-110(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Liver.
[2]	"cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)." Kiuchi Y., Suzuki H., Hirohashi T., Tyson C.A., Sugiyama Y. FEBS Lett. 433:149-152(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins." Belinsky M.G., Bain L.J., Balsara B.B., Testa J.R., Kruh G.D. J. Natl. Cancer Inst. 90:1735-1741(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants." Fromm M.F., Leake B., Roden D.M., Wilkinson G.R., Kim R.B. Biochim. Biophys. Acta 1415:369-374(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Liver.
[5]	"Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane." Koenig J., Rost D., Cui Y., Keppler D. Hepatology 29:1156-1163(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Liver.
[6]	"Complete coding sequence of human MRP3, a homolog of the human multidrug resistance-associated protein MRP1." Kool M., de Haas M., Ponne N.J., Baas F., Borst P. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Liver.
[7]	"Identification of a novel splice variant of MRP3 involved in resistance to DNA damaging agents." Auclair D., Alonso E., Chen L.B. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Colon carcinoma.
[8]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5). Tissue: Blood.
[11]	"Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines." Kool M., de Haas M., Scheffer G.L., Scheper R.J., van Eijk M.J., Juijn J.A., Baas F., Borst P. Cancer Res. 57:3537-3547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1043-1527 (ISOFORM 1). Tissue: Liver.
[12]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.

Web resources

ABCMdb

Database for mutations in ABC proteins

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF083552 mRNA. Translation: AAC34668.1. AB010887 mRNA. Translation: BAA28146.1. AF104943 mRNA. Translation: AAD04170.1. AF085690 mRNA. Translation: AAD02845.1. AF085691 mRNA. Translation: AAD02846.1. AF085692 mRNA. Translation: AAD02847.1. Y17151 mRNA. Translation: CAA76658.2. AF009670 mRNA. Translation: AAD01430.1. Frameshift. AF154001 mRNA. Translation: AAD38185.1. Sequence problems. AC004590 Genomic DNA. No translation available. AC005921 Genomic DNA. No translation available. CH471109 Genomic DNA. Translation: EAW94592.1. CH471109 Genomic DNA. Translation: EAW94590.1. CH471109 Genomic DNA. Translation: EAW94593.1. BC046126 mRNA. Translation: AAH46126.1. BC137347 mRNA. Translation: AAI37348.1. BC137348 mRNA. Translation: AAI37349.1. U83659 mRNA. Translation: AAB71756.1. Frameshift.
IPI	IPI00006674. IPI00219843. IPI00219844. IPI00251066. IPI00797470.
PIR	JE0336.
RefSeq	NP_001137542.1. NM_001144070.1. NP_003777.2. NM_003786.3.
UniGene	Hs.463421.
3D structure databases
ProteinModelPortal	O15438.
SMR	O15438. Positions 596-853, 949-1525.
ModBase	Search...
Protein-protein interaction databases
IntAct	O15438. 5 interactions.
STRING	9606.ENSP00000285238.
Protein family/group databases
TCDB	3.A.1.208.9. ATP-binding cassette (ABC) superfamily.
PTM databases
PhosphoSite	O15438.
Proteomic databases
PaxDb	O15438.
PRIDE	O15438.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000285238; ENSP00000285238; ENSG00000108846. ENST00000427699; ENSP00000395160; ENSG00000108846. ENST00000502426; ENSP00000427073; ENSG00000108846. ENST00000505699; ENSP00000427521; ENSG00000108846.
GeneID	8714.
KEGG	hsa:8714.
UCSC	uc002isk.4. human. uc002isl.3. human. uc002isn.3. human.
Organism-specific databases
CTD	8714.
GeneCards	GC17P048712.
HGNC	HGNC:54. ABCC3.
HPA	CAB037136.
MIM	604323. gene.
neXtProt	NX_O15438.
PharmGKB	PA376.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1132.
HOVERGEN	HBG108314.
InParanoid	O15438.
KO	K05667.
OMA	NQKSCYP.
OrthoDB	EOG4TTGH1.
PhylomeDB	O15438.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	O15438.
Bgee	O15438.
CleanEx	HS_ABCC3.
Genevestigator	O15438.
GermOnline	ENSG00000108846. Homo sapiens.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR005292. Multidrug-R_assoc. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 2 hits.
TIGRFAMs	TIGR00957. MRP_assoc_pro. 1 hit.
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
BindingDB	O15438.
ChEMBL	CHEMBL5918.
ChiTaRS	ABCC3. human.
DrugBank	DB01016. Glibenclamide.
GenomeRNAi	8714.
NextBio	32679.
SOURCE	Search...

Entry information

Entry name

MRP3_HUMAN

Accession

Primary (citable) accession number: O15438
Secondary accession number(s): B2RPA9 , D3DTX9, O60265, O60922, O75621, O95078, O95289, O95290, Q86X85, Q9UN52

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 30, 2000
Last modified:	April 3, 2013
This is version 126 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.