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Protein

Probable low affinity copper uptake protein 2

Gene

SLC31A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in low-affinity copper uptake.Curated

GO - Molecular functioni

  • copper ion transmembrane transporter activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

Copper

Protein family/group databases

TCDBi1.A.56.1.9. the copper transporter (ctr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable low affinity copper uptake protein 2
Alternative name(s):
Copper transporter 2
Short name:
hCTR2
Solute carrier family 31 member 2
Gene namesi
Name:SLC31A2
Synonyms:COPT2, CTR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11017. SLC31A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321HelicalSequence analysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • late endosome Source: Ensembl
  • recycling endosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35886.

Chemistry

DrugBankiDB00958. Carboplatin.
DB00515. Cisplatin.

Polymorphism and mutation databases

BioMutaiSLC31A2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143Probable low affinity copper uptake protein 2PRO_0000195043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO15432.
PRIDEiO15432.

PTM databases

PhosphoSiteiO15432.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiO15432.
CleanExiHS_SLC31A2.
ExpressionAtlasiO15432. baseline and differential.
GenevisibleiO15432. HS.

Organism-specific databases

HPAiHPA014861.

Interactioni

Protein-protein interaction databases

BioGridi107713. 6 interactions.
MINTiMINT-2998980.
STRINGi9606.ENSP00000259392.

Structurei

3D structure databases

ProteinModelPortaliO15432.
SMRiO15432. Positions 93-119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3386. Eukaryota.
ENOG4111I8D. LUCA.
HOGENOMiHOG000195393.
HOVERGENiHBG106679.
InParanoidiO15432.
KOiK14687.
OMAiYPLLRMV.
OrthoDBiEOG7CCBT8.
PhylomeDBiO15432.
TreeFamiTF315142.

Family and domain databases

InterProiIPR007274. Cop_transporter.
[Graphical view]
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiPF04145. Ctr. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMHFIFSDT AVLLFDFWSV HSPAGMALSV LVLLLLAVLY EGIKVGKAKL
60 70 80 90 100
LNQVLVNLPT SISQQTIAET DGDSAGSDSF PVGRTHHRWY LCHFGQSLIH
110 120 130 140
VIQVVIGYFI MLAVMSYNTW IFLGVVLGSA VGYYLAYPLL STA
Length:143
Mass (Da):15,681
Last modified:January 1, 1998 - v1
Checksum:i0145EE8BE623443E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83461 mRNA. Translation: AAB66307.1.
BC026252 mRNA. Translation: AAH26252.1.
CCDSiCCDS6788.1.
RefSeqiNP_001851.1. NM_001860.2.
UniGeneiHs.24030.

Genome annotation databases

EnsembliENST00000259392; ENSP00000259392; ENSG00000136867.
GeneIDi1318.
KEGGihsa:1318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83461 mRNA. Translation: AAB66307.1.
BC026252 mRNA. Translation: AAH26252.1.
CCDSiCCDS6788.1.
RefSeqiNP_001851.1. NM_001860.2.
UniGeneiHs.24030.

3D structure databases

ProteinModelPortaliO15432.
SMRiO15432. Positions 93-119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107713. 6 interactions.
MINTiMINT-2998980.
STRINGi9606.ENSP00000259392.

Chemistry

DrugBankiDB00958. Carboplatin.
DB00515. Cisplatin.

Protein family/group databases

TCDBi1.A.56.1.9. the copper transporter (ctr) family.

PTM databases

PhosphoSiteiO15432.

Polymorphism and mutation databases

BioMutaiSLC31A2.

Proteomic databases

PaxDbiO15432.
PRIDEiO15432.

Protocols and materials databases

DNASUi1318.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259392; ENSP00000259392; ENSG00000136867.
GeneIDi1318.
KEGGihsa:1318.

Organism-specific databases

CTDi1318.
GeneCardsiSLC31A2.
HGNCiHGNC:11017. SLC31A2.
HPAiHPA014861.
MIMi603088. gene.
neXtProtiNX_O15432.
PharmGKBiPA35886.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3386. Eukaryota.
ENOG4111I8D. LUCA.
HOGENOMiHOG000195393.
HOVERGENiHBG106679.
InParanoidiO15432.
KOiK14687.
OMAiYPLLRMV.
OrthoDBiEOG7CCBT8.
PhylomeDBiO15432.
TreeFamiTF315142.

Miscellaneous databases

GeneWikiiSLC31A2.
GenomeRNAii1318.
NextBioi5391.
PROiO15432.
SOURCEiSearch...

Gene expression databases

BgeeiO15432.
CleanExiHS_SLC31A2.
ExpressionAtlasiO15432. baseline and differential.
GenevisibleiO15432. HS.

Family and domain databases

InterProiIPR007274. Cop_transporter.
[Graphical view]
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiPF04145. Ctr. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "hCTR1: a human gene for copper uptake identified by complementation in yeast."
    Zhou B., Gitschier J.
    Proc. Natl. Acad. Sci. U.S.A. 94:7481-7486(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiCOPT2_HUMAN
AccessioniPrimary (citable) accession number: O15432
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: March 16, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.