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Protein

High affinity copper uptake protein 1

Gene

SLC31A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity, saturable copper transporter involved in dietary copper uptake.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCopper transport, Ion transport, Transport
LigandCopper

Enzyme and pathway databases

ReactomeiR-HSA-425410. Metal ion SLC transporters.

Protein family/group databases

TCDBi1.A.56.1.2. the copper transporter (ctr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity copper uptake protein 1
Alternative name(s):
Copper transporter 1
Short name:
hCTR1
Solute carrier family 31 member 1
Gene namesi
Name:SLC31A1
Synonyms:COPT1, CTR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136868.10.
HGNCiHGNC:11016. SLC31A1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61ExtracellularSequence analysisAdd BLAST61
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 132CytoplasmicSequence analysisAdd BLAST50
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 156ExtracellularSequence analysis3
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 190CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1317.
OpenTargetsiENSG00000136868.
PharmGKBiPA118.

Chemistry databases

DrugBankiDB00958. Carboplatin.
DB00515. Cisplatin.
DB00526. Oxaliplatin.

Polymorphism and mutation databases

BioMutaiSLC31A1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001950401 – 190High affinity copper uptake protein 1Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi15N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi27O-linked (GalNAc...) threonine1 Publication1
Modified residuei114PhosphothreonineCombined sources1

Post-translational modificationi

O-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO15431.
MaxQBiO15431.
PaxDbiO15431.
PeptideAtlasiO15431.
PRIDEiO15431.

PTM databases

iPTMnetiO15431.
PhosphoSitePlusiO15431.

Expressioni

Gene expression databases

BgeeiENSG00000136868.
CleanExiHS_SLC31A1.
ExpressionAtlasiO15431. baseline and differential.
GenevisibleiO15431. HS.

Organism-specific databases

HPAiHPA013810.

Interactioni

Subunit structurei

Homotrimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-15571835,EBI-15571835

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi107712. 12 interactors.
DIPiDIP-48727N.
MINTiMINT-5003806.
STRINGi9606.ENSP00000363329.

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi67 – 82Combined sources16
Turni83 – 85Combined sources3
Helixi134 – 155Combined sources22
Beta strandi160 – 162Combined sources3
Helixi163 – 168Combined sources6
Helixi174 – 177Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LS2NMR-A64-87[»]
2LS3NMR-A132-157[»]
2LS4NMR-A156-179[»]
ProteinModelPortaliO15431.
SMRiO15431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3386. Eukaryota.
ENOG4111I8D. LUCA.
GeneTreeiENSGT00530000063415.
HOGENOMiHOG000195393.
HOVERGENiHBG065767.
InParanoidiO15431.
KOiK14686.
OMAiHMMPMAF.
OrthoDBiEOG091G0VVR.
PhylomeDBiO15431.
TreeFamiTF315142.

Family and domain databases

InterProiView protein in InterPro
IPR007274. Cop_transporter.
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiView protein in Pfam
PF04145. Ctr. 1 hit.

Sequencei

Sequence statusi: Complete.

O15431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHSHHMGMS YMDSNSTMQP SHHHPTTSAS HSHGGGDSSM MMMPMTFYFG
60 70 80 90 100
FKNVELLFSG LVINTAGEMA GAFVAVFLLA MFYEGLKIAR ESLLRKSQVS
110 120 130 140 150
IRYNSMPVPG PNGTILMETH KTVGQQMLSF PHLLQTVLHI IQVVISYFLM
160 170 180 190
LIFMTYNGYL CIAVAAGAGT GYFLFSWKKA VVVDITEHCH
Length:190
Mass (Da):21,091
Last modified:January 1, 1998 - v1
Checksum:i1E08FBAB72A9C014
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168A → G in BAD96586 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02933825P → A. Corresponds to variant dbSNP:rs2233915Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83460 mRNA. Translation: AAB66306.1.
AK222866 mRNA. Translation: BAD96586.1.
AK292511 mRNA. Translation: BAF85200.1.
AL831843 mRNA. Translation: CAD38549.1.
AL449305 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW87357.1.
BC013611 mRNA. Translation: AAH13611.1.
CCDSiCCDS6789.1.
RefSeqiNP_001850.1. NM_001859.3.
UniGeneiHs.532315.

Genome annotation databases

EnsembliENST00000374212; ENSP00000363329; ENSG00000136868.
GeneIDi1317.
KEGGihsa:1317.
UCSCiuc004bgu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOPT1_HUMAN
AccessioniPrimary (citable) accession number: O15431
Secondary accession number(s): A8K8Z6, Q53GR5, Q5T1M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: October 25, 2017
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families