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Protein

Monocarboxylate transporter 4

Gene

SLC16A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

Caution

Was initially assigned as monocarboxylate transporter 3 (MCT3) (PubMed:9425115). However, it was later shown that it corresponds to monocarboxylate transporter 4 (MCT4).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-210991 Basigin interactions
R-HSA-433692 Proton-coupled monocarboxylate transport
R-HSA-70268 Pyruvate metabolism
SIGNORiO15427

Protein family/group databases

TCDBi2.A.1.13.6 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 4
Short name:
MCT 4
Alternative name(s):
Solute carrier family 16 member 3
Gene namesi
Name:SLC16A3
Synonyms:MCT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141526.14
HGNCiHGNC:10924 SLC16A3
MIMi603877 gene
neXtProtiNX_O15427

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 17CytoplasmicSequence analysisAdd BLAST16
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 61ExtracellularSequence analysisAdd BLAST23
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 84CytoplasmicSequence analysis2
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 109ExtracellularSequence analysis4
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 149CytoplasmicSequence analysisAdd BLAST19
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 179ExtracellularSequence analysis9
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 227CytoplasmicSequence analysisAdd BLAST27
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 264ExtracellularSequence analysisAdd BLAST16
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Topological domaini286 – 294CytoplasmicSequence analysis9
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 317ExtracellularSequence analysis2
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 351CytoplasmicSequence analysisAdd BLAST13
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 384ExtracellularSequence analysisAdd BLAST12
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 465CytoplasmicSequence analysisAdd BLAST60

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9123
OpenTargetsiENSG00000141526
PharmGKBiPA35815

Chemistry databases

ChEMBLiCHEMBL2073663
DrugBankiDB03884 3-Phenylpyruvic Acid
DB01762 Acetoacetic Acid
DB04074 Alpha-ketoisovalerate
DB03066 D-Lactic Acid
DB01942 Formic Acid
DB01440 Gamma Hydroxybutyric Acid
DB04398 Lactic Acid
DB00627 Niacin
DB03940 Oxamic Acid
DB00119 Pyruvic acid

Polymorphism and mutation databases

BioMutaiSLC16A3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002113942 – 465Monocarboxylate transporter 4Add BLAST464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei436PhosphoserineCombined sources1
Modified residuei460PhosphothreonineCombined sources1
Modified residuei464PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15427
MaxQBiO15427
PaxDbiO15427
PeptideAtlasiO15427
PRIDEiO15427

PTM databases

iPTMnetiO15427
PhosphoSitePlusiO15427
SwissPalmiO15427

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle.

Gene expression databases

BgeeiENSG00000141526
CleanExiHS_SLC16A3
ExpressionAtlasiO15427 baseline and differential
GenevisibleiO15427 HS

Organism-specific databases

HPAiCAB017490
HPA021451

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114571, 10 interactors
IntActiO15427, 15 interactors
MINTiO15427
STRINGi9606.ENSP00000376150

Chemistry databases

BindingDBiO15427

Structurei

3D structure databases

ProteinModelPortaliO15427
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMVU Eukaryota
ENOG4111A50 LUCA
GeneTreeiENSGT00760000118926
HOGENOMiHOG000280688
HOVERGENiHBG006384
InParanoidiO15427
KOiK08180
OMAiSMPQVHI
OrthoDBiEOG091G05SW
PhylomeDBiO15427
TreeFamiTF313792

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004743 MCT
IPR030756 MCT4
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF27 PTHR11360:SF27, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00892 2A0113, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGAVVDEGP TGVKAPDGGW GWAVLFGCFV ITGFSYAFPK AVSVFFKELI
60 70 80 90 100
QEFGIGYSDT AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL
110 120 130 140 150
GMVAASFCRS IIQVYLTTGV ITGLGLALNF QPSLIMLNRY FSKRRPMANG
160 170 180 190 200
LAAAGSPVFL CALSPLGQLL QDRYGWRGGF LILGGLLLNC CVCAALMRPL
210 220 230 240 250
VVTAQPGSGP PRPSRRLLDL SVFRDRGFVL YAVAASVMVL GLFVPPVFVV
260 270 280 290 300
SYAKDLGVPD TKAAFLLTIL GFIDIFARPA AGFVAGLGKV RPYSVYLFSF
310 320 330 340 350
SMFFNGLADL AGSTAGDYGG LVVFCIFFGI SYGMVGALQF EVLMAIVGTH
360 370 380 390 400
KFSSAIGLVL LMEAVAVLVG PPSGGKLLDA THVYMYVFIL AGAEVLTSSL
410 420 430 440 450
ILLLGNFFCI RKKPKEPQPE VAAAEEEKLH KPPADSGVDL REVEHFLKAE
460
PEKNGEVVHT PETSV
Length:465
Mass (Da):49,469
Last modified:January 1, 1998 - v1
Checksum:i7BF6384B0F14D927
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81800 mRNA Translation: AAC52015.1
AK127319 mRNA Translation: BAG54480.1
BC112267 mRNA Translation: AAI12268.1
BC112269 mRNA Translation: AAI12270.1
CCDSiCCDS11804.1
RefSeqiNP_001035887.1, NM_001042422.2
NP_001035888.1, NM_001042423.2
NP_001193879.1, NM_001206950.1
NP_001193880.1, NM_001206951.1
NP_001193881.1, NM_001206952.1
NP_004198.1, NM_004207.3
XP_011521909.1, XM_011523607.1
UniGeneiHs.500761

Genome annotation databases

EnsembliENST00000392339; ENSP00000376150; ENSG00000141526
ENST00000392341; ENSP00000376152; ENSG00000141526
ENST00000581287; ENSP00000463978; ENSG00000141526
ENST00000582743; ENSP00000462405; ENSG00000141526
ENST00000617373; ENSP00000483212; ENSG00000141526
ENST00000619321; ENSP00000482013; ENSG00000141526
GeneIDi9123
KEGGihsa:9123
UCSCiuc002keb.4 human

Similar proteinsi

Entry informationi

Entry nameiMOT4_HUMAN
AccessioniPrimary (citable) accession number: O15427
Secondary accession number(s): B3KXG8, Q2M1P8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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