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Protein

Monocarboxylate transporter 4

Gene

SLC16A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141526-MONOMER.
ReactomeiR-HSA-210991. Basigin interactions.
R-HSA-433692. Proton-coupled monocarboxylate transport.
R-HSA-70268. Pyruvate metabolism.
SIGNORiO15427.

Protein family/group databases

TCDBi2.A.1.13.6. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 4
Short name:
MCT 4
Alternative name(s):
Solute carrier family 16 member 3
Gene namesi
Name:SLC16A3
Synonyms:MCT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10924. SLC16A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 17CytoplasmicSequence analysisAdd BLAST16
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 61ExtracellularSequence analysisAdd BLAST23
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 84CytoplasmicSequence analysis2
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 109ExtracellularSequence analysis4
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 149CytoplasmicSequence analysisAdd BLAST19
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 179ExtracellularSequence analysis9
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 227CytoplasmicSequence analysisAdd BLAST27
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 264ExtracellularSequence analysisAdd BLAST16
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Topological domaini286 – 294CytoplasmicSequence analysis9
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 317ExtracellularSequence analysis2
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 351CytoplasmicSequence analysisAdd BLAST13
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 384ExtracellularSequence analysisAdd BLAST12
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 465CytoplasmicSequence analysisAdd BLAST60

GO - Cellular componenti

  • actin cytoskeleton Source: HPA
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • nuclear membrane Source: HPA
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9123.
OpenTargetsiENSG00000141526.
PharmGKBiPA35815.

Chemistry databases

ChEMBLiCHEMBL2073663.
DrugBankiDB01440. Gamma Hydroxybutyric Acid.
DB04398. Lactic Acid.
DB00627. Niacin.
DB00119. Pyruvic acid.

Polymorphism and mutation databases

BioMutaiSLC16A3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002113942 – 465Monocarboxylate transporter 4Add BLAST464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei436PhosphoserineCombined sources1
Modified residuei460PhosphothreonineCombined sources1
Modified residuei464PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15427.
MaxQBiO15427.
PaxDbiO15427.
PeptideAtlasiO15427.
PRIDEiO15427.

PTM databases

iPTMnetiO15427.
PhosphoSitePlusiO15427.
SwissPalmiO15427.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle.

Gene expression databases

BgeeiENSG00000141526.
CleanExiHS_SLC16A3.
ExpressionAtlasiO15427. baseline and differential.
GenevisibleiO15427. HS.

Organism-specific databases

HPAiCAB017490.
HPA021451.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BANPQ8N9N53EBI-7600166,EBI-744695
FAM9BQ8IZU03EBI-7600166,EBI-10175124
NR2C2APQ86WQ03EBI-7600166,EBI-10260040

Protein-protein interaction databases

BioGridi114571. 8 interactors.
IntActiO15427. 15 interactors.
MINTiMINT-4526381.
STRINGi9606.ENSP00000376150.

Chemistry databases

BindingDBiO15427.

Structurei

3D structure databases

ProteinModelPortaliO15427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMVU. Eukaryota.
ENOG4111A50. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO15427.
KOiK08180.
OMAiMGVPDTK.
OrthoDBiEOG091G05SW.
PhylomeDBiO15427.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004743. MCT.
IPR030756. MCT4.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF27. PTHR11360:SF27. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGAVVDEGP TGVKAPDGGW GWAVLFGCFV ITGFSYAFPK AVSVFFKELI
60 70 80 90 100
QEFGIGYSDT AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL
110 120 130 140 150
GMVAASFCRS IIQVYLTTGV ITGLGLALNF QPSLIMLNRY FSKRRPMANG
160 170 180 190 200
LAAAGSPVFL CALSPLGQLL QDRYGWRGGF LILGGLLLNC CVCAALMRPL
210 220 230 240 250
VVTAQPGSGP PRPSRRLLDL SVFRDRGFVL YAVAASVMVL GLFVPPVFVV
260 270 280 290 300
SYAKDLGVPD TKAAFLLTIL GFIDIFARPA AGFVAGLGKV RPYSVYLFSF
310 320 330 340 350
SMFFNGLADL AGSTAGDYGG LVVFCIFFGI SYGMVGALQF EVLMAIVGTH
360 370 380 390 400
KFSSAIGLVL LMEAVAVLVG PPSGGKLLDA THVYMYVFIL AGAEVLTSSL
410 420 430 440 450
ILLLGNFFCI RKKPKEPQPE VAAAEEEKLH KPPADSGVDL REVEHFLKAE
460
PEKNGEVVHT PETSV
Length:465
Mass (Da):49,469
Last modified:January 1, 1998 - v1
Checksum:i7BF6384B0F14D927
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81800 mRNA. Translation: AAC52015.1.
AK127319 mRNA. Translation: BAG54480.1.
BC112267 mRNA. Translation: AAI12268.1.
BC112269 mRNA. Translation: AAI12270.1.
CCDSiCCDS11804.1.
RefSeqiNP_001035887.1. NM_001042422.2.
NP_001035888.1. NM_001042423.2.
NP_001193879.1. NM_001206950.1.
NP_001193880.1. NM_001206951.1.
NP_001193881.1. NM_001206952.1.
NP_004198.1. NM_004207.3.
XP_011521909.1. XM_011523607.1.
UniGeneiHs.500761.

Genome annotation databases

EnsembliENST00000392339; ENSP00000376150; ENSG00000141526.
ENST00000392341; ENSP00000376152; ENSG00000141526.
ENST00000581287; ENSP00000463978; ENSG00000141526.
ENST00000582743; ENSP00000462405; ENSG00000141526.
ENST00000617373; ENSP00000483212; ENSG00000141526.
ENST00000619321; ENSP00000482013; ENSG00000141526.
GeneIDi9123.
KEGGihsa:9123.
UCSCiuc002keb.4. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81800 mRNA. Translation: AAC52015.1.
AK127319 mRNA. Translation: BAG54480.1.
BC112267 mRNA. Translation: AAI12268.1.
BC112269 mRNA. Translation: AAI12270.1.
CCDSiCCDS11804.1.
RefSeqiNP_001035887.1. NM_001042422.2.
NP_001035888.1. NM_001042423.2.
NP_001193879.1. NM_001206950.1.
NP_001193880.1. NM_001206951.1.
NP_001193881.1. NM_001206952.1.
NP_004198.1. NM_004207.3.
XP_011521909.1. XM_011523607.1.
UniGeneiHs.500761.

3D structure databases

ProteinModelPortaliO15427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114571. 8 interactors.
IntActiO15427. 15 interactors.
MINTiMINT-4526381.
STRINGi9606.ENSP00000376150.

Chemistry databases

BindingDBiO15427.
ChEMBLiCHEMBL2073663.
DrugBankiDB01440. Gamma Hydroxybutyric Acid.
DB04398. Lactic Acid.
DB00627. Niacin.
DB00119. Pyruvic acid.

Protein family/group databases

TCDBi2.A.1.13.6. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiO15427.
PhosphoSitePlusiO15427.
SwissPalmiO15427.

Polymorphism and mutation databases

BioMutaiSLC16A3.

Proteomic databases

EPDiO15427.
MaxQBiO15427.
PaxDbiO15427.
PeptideAtlasiO15427.
PRIDEiO15427.

Protocols and materials databases

DNASUi9123.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392339; ENSP00000376150; ENSG00000141526.
ENST00000392341; ENSP00000376152; ENSG00000141526.
ENST00000581287; ENSP00000463978; ENSG00000141526.
ENST00000582743; ENSP00000462405; ENSG00000141526.
ENST00000617373; ENSP00000483212; ENSG00000141526.
ENST00000619321; ENSP00000482013; ENSG00000141526.
GeneIDi9123.
KEGGihsa:9123.
UCSCiuc002keb.4. human.

Organism-specific databases

CTDi9123.
DisGeNETi9123.
GeneCardsiSLC16A3.
HGNCiHGNC:10924. SLC16A3.
HPAiCAB017490.
HPA021451.
MIMi603877. gene.
neXtProtiNX_O15427.
OpenTargetsiENSG00000141526.
PharmGKBiPA35815.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMVU. Eukaryota.
ENOG4111A50. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO15427.
KOiK08180.
OMAiMGVPDTK.
OrthoDBiEOG091G05SW.
PhylomeDBiO15427.
TreeFamiTF313792.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141526-MONOMER.
ReactomeiR-HSA-210991. Basigin interactions.
R-HSA-433692. Proton-coupled monocarboxylate transport.
R-HSA-70268. Pyruvate metabolism.
SIGNORiO15427.

Miscellaneous databases

ChiTaRSiSLC16A3. human.
GeneWikiiSLC16A3.
GenomeRNAii9123.
PROiO15427.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141526.
CleanExiHS_SLC16A3.
ExpressionAtlasiO15427. baseline and differential.
GenevisibleiO15427. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004743. MCT.
IPR030756. MCT4.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF27. PTHR11360:SF27. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOT4_HUMAN
AccessioniPrimary (citable) accession number: O15427
Secondary accession number(s): B3KXG8, Q2M1P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was initially assigned as monocarboxylate transporter 3 (MCT3) (PubMed:9425115). However, it was later shown that it corresponds to monocarboxylate transporter 4 (MCT4).1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.