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O15409

- FOXP2_HUMAN

UniProt

O15409 - FOXP2_HUMAN

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Protein
Forkhead box protein P2
Gene
FOXP2, CAGH44, TNRC10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri346 – 37126C2H2-type
Add
BLAST
DNA bindingi504 – 59491Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. DNA binding, bending Source: RefGenome
  3. chromatin binding Source: RefGenome
  4. metal ion binding Source: UniProtKB-KW
  5. protein heterodimerization activity Source: RefGenome
  6. protein homodimerization activity Source: UniProtKB
  7. sequence-specific DNA binding Source: BHF-UCL
  8. sequence-specific DNA binding transcription factor activity Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

  1. camera-type eye development Source: RefGenome
  2. caudate nucleus development Source: UniProtKB
  3. cerebellum development Source: RefGenome
  4. cerebral cortex development Source: BHF-UCL
  5. embryo development Source: Ensembl
  6. growth Source: RefGenome
  7. lung alveolus development Source: RefGenome
  8. negative regulation of transcription, DNA-templated Source: BHF-UCL
  9. pattern specification process Source: RefGenome
  10. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: RefGenome
  11. positive regulation of mesenchymal cell proliferation Source: RefGenome
  12. post-embryonic development Source: RefGenome
  13. putamen development Source: UniProtKB
  14. righting reflex Source: RefGenome
  15. skeletal muscle tissue development Source: RefGenome
  16. smooth muscle tissue development Source: RefGenome
  17. transcription, DNA-templated Source: UniProtKB-KW
  18. vocal learning Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P2
Alternative name(s):
CAG repeat protein 44
Trinucleotide repeat-containing gene 10 protein
Gene namesi
Name:FOXP2
Synonyms:CAGH44, TNRC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:13875. FOXP2.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Speech-language disorder 1 (SPCH1) [MIM:602081]: A disorder characterized by severe orofacial dyspraxia resulting in largely incomprehensible speech. Affected individuals have severe impairment in the selection and sequencing of fine orofacial movements which are necessary for articulation, and deficits in several facets of grammatical skills and language processing, such as the ability to break up words into their constituent phonemes.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti553 – 5531R → H in SPCH1. 1 Publication
VAR_012278
A chromosomal aberration involving FOXP2 is a cause of severe speech and language impairment. Translocation t(5;7)(q22;q31.2).

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi602081. phenotype.
Orphaneti251061. 7q31 microdeletion syndrome.
209908. Childhood apraxia of speech.
PharmGKBiPA28242.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 715715Forkhead box protein P2
PRO_0000091879Add
BLAST

Proteomic databases

MaxQBiO15409.
PaxDbiO15409.
PRIDEiO15409.

PTM databases

PhosphoSiteiO15409.

Expressioni

Tissue specificityi

Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung.1 Publication

Developmental stagei

Expressed in the brain at 15 and 22 weeks of gestation, with a pattern of strong cortical, basal ganglia, thalamic and cerebellar expression. Highly expressed in the head and tail of nucleus caudatus and putamen. Restricted expression within the globus pallidus, with high levels in the pars interna, which provides the principal source of output from the basal ganglia to the nucleus centrum medianum thalami (CM) and the major motor relay nuclei of the thalamus. In the thalamus, present in the CM and nucleus medialis dorsalis thalami. Lower levels are observed in the nuclei anterior thalami, dorsal and ventral, and the nucleus parafascicularis thalami. Expressed in the ventrobasal complex comprising the nucleus ventralis posterior lateralis/medialis. The ventral tier of the thalamus exhibits strong expression, including nuclei ventralis anterior, lateralis and posterior lateralis pars oralis. Also expressed in the nucleus subthalamicus bilaterally and in the nucleus ruber.1 Publication

Gene expression databases

ArrayExpressiO15409.
BgeeiO15409.
GenevestigatoriO15409.

Organism-specific databases

HPAiCAB011488.
HPA000382.
HPA000383.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 By similarity.

Protein-protein interaction databases

BioGridi125073. 6 interactions.
DIPiDIP-29004N.
IntActiO15409. 1 interaction.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi509 – 51911
Helixi527 – 54115
Helixi545 – 55814
Beta strandi562 – 5676
Beta strandi568 – 5725
Helixi577 – 5837

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A07X-ray1.90F/G/H/I/J/K502-594[»]
2AS5X-ray2.70F/G502-594[»]
ProteinModelPortaliO15409.
SMRiO15409. Positions 351-409, 503-584.

Miscellaneous databases

EvolutionaryTraceiO15409.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni388 – 40922Leucine-zipper
Add
BLAST
Regioni422 – 4265CTBP1-binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi53 – 268216Gln-rich
Add
BLAST

Domaini

The leucine-zipper is required for dimerization and transcriptional repression By similarity.

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.
KOiK09409.
OMAiPETKLCV.
OrthoDBiEOG7M6D7G.
PhylomeDBiO15409.
TreeFamiTF326978.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O15409-1) [UniParc]FASTAAdd to Basket

Also known as: I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL    50
HLQQQQALQA ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT 100
PQQMQQILQQ QVLSPQQLQA LLQQQQAVML QQQQLQEFYK KQQEQLHLQL 150
LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QHPGKQAKEQ 200
QQQQQQQQQL AAQQLVFQQQ LLQMQQLQQQ QHLLSLQRQG LISIPPGQAA 250
LPVQSLPQAG LSPAEIQQLW KEVTGVHSME DNGIKHGGLD LTTNNSSSTT 300
SSNTSKASPP ITHHSIVNGQ SSVLSARRDS SSHEETGASH TLYGHGVCKW 350
PGCESICEDF GQFLKHLNNE HALDDRSTAQ CRVQMQVVQQ LEIQLSKERE 400
RLQAMMTHLH MRPSEPKPSP KPLNLVSSVT MSKNMLETSP QSLPQTPTTP 450
TAPVTPITQG PSVITPASVP NVGAIRRRHS DKYNIPMSSE IAPNYEFYKN 500
ADVRPPFTYA TLIRQAIMES SDRQLTLNEI YSWFTRTFAY FRRNAATWKN 550
AVRHNLSLHK CFVRVENVKG AVWTVDEVEY QKRRSQKITG SPTLVKNIPT 600
SLGYGAALNA SLQAALAESS LPLLSNPGLI NNASSGLLQA VHEDLNGSLD 650
HIDSNGNSSP GCSPQPHIHS IHVKEEPVIA EDEDCPMSLV TTANHSPELE 700
DDREIEEEPL SEDLE 715
Length:715
Mass (Da):79,919
Last modified:December 5, 2001 - v2
Checksum:i4F9FBDB6D90516E0
GO
Isoform 2 (identifier: O15409-3)

Also known as: II

Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: O15409-2) [UniParc]FASTAAdd to Basket

Also known as: III, IV

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:623
Mass (Da):70,104
Checksum:iF78EA67F33A3AE05
GO
Isoform 4 (identifier: O15409-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-86: Q → QELLPETKLCICGHSSGDGHPHNTFA

Show »
Length:740
Mass (Da):82,565
Checksum:i423EC421368FCD94
GO
Isoform 5 (identifier: O15409-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-86: Q → QELLPETKLCICGHSSGDGHPHNTFA
     133-143: QQLQEFYKKQQ → VMWVTCFGVLA
     144-715: Missing.

Show »
Length:168
Mass (Da):18,315
Checksum:i61B297B4D64BC670
GO
Isoform 6 (identifier: O15409-6) [UniParc]FASTAAdd to Basket

Also known as: FOXP2-S

The sequence of this isoform differs from the canonical sequence as follows:
     423-432: LNLVSSVTMS → VSAYCFINSK
     433-715: Missing.

Show »
Length:432
Mass (Da):48,764
Checksum:i42BC7890ACAF498C
GO
Isoform 7 (identifier: O15409-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-715: Missing.

Show »
Length:365
Mass (Da):40,969
Checksum:i0B052282E2E30771
GO
Isoform 8 (identifier: O15409-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-87: V → P
     88-715: Missing.

Note: No experimental confirmation available.

Show »
Length:87
Mass (Da):9,377
Checksum:i624274B876E062E4
GO
Isoform 9 (identifier: O15409-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-132: Q → QDFLDSGLENFRAALEKN

Note: No experimental confirmation available.

Show »
Length:732
Mass (Da):81,840
Checksum:i8B72F946ABD821EE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti553 – 5531R → H in SPCH1. 1 Publication
VAR_012278

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9292Missing in isoform 3.
VSP_001558Add
BLAST
Alternative sequencei86 – 861Q → QELLPETKLCICGHSSGDGH PHNTFA in isoform 4 and isoform 5.
VSP_011532
Alternative sequencei87 – 871V → P in isoform 8.
VSP_011533
Alternative sequencei88 – 715628Missing in isoform 8.
VSP_011534Add
BLAST
Alternative sequencei132 – 1321Q → QDFLDSGLENFRAALEKN in isoform 9.
VSP_043464
Alternative sequencei133 – 14311QQLQEFYKKQQ → VMWVTCFGVLA in isoform 5.
VSP_011535Add
BLAST
Alternative sequencei144 – 715572Missing in isoform 5.
VSP_011536Add
BLAST
Alternative sequencei366 – 715350Missing in isoform 7.
VSP_011537Add
BLAST
Alternative sequencei423 – 43210LNLVSSVTMS → VSAYCFINSK in isoform 6.
VSP_011538
Alternative sequencei433 – 715283Missing in isoform 6.
VSP_011539Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291A → V in AAM60762. 1 Publication
Sequence conflicti134 – 1341Q → H in AAB91439. 1 Publication
Sequence conflicti290 – 30415DLTTN…TSSNT → EEFPVQGPAAVCAGL in AAB91439. 1 Publication
Add
BLAST
Sequence conflicti414 – 4141S → L in AAM60766. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF337817 mRNA. Translation: AAL10762.1.
AF467252 mRNA. Translation: AAM60762.1.
AF467253 mRNA. Translation: AAM60763.1.
AF467254 mRNA. Translation: AAM60764.1.
AF467255 mRNA. Translation: AAM60765.1.
AF467256 mRNA. Translation: AAM60766.1.
AF467257 mRNA. Translation: AAM60767.1.
AF493430 mRNA. Translation: AAM13672.1.
AY144615 mRNA. Translation: AAN60016.1.
AK131266 mRNA. Translation: BAD18444.1. Sequence problems.
AK296957 mRNA. Translation: BAG59501.1.
AC003992 Genomic DNA. Translation: AAS07399.1.
AC020606 Genomic DNA. Translation: AAS07502.1.
AC073626 Genomic DNA. No translation available.
AC074000 Genomic DNA. No translation available.
AC092148 Genomic DNA. No translation available.
AC092606 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24367.1.
CH236947 Genomic DNA. Translation: EAL24369.1.
CH471070 Genomic DNA. Translation: EAW83484.1.
CH471070 Genomic DNA. Translation: EAW83486.1.
BC126104 mRNA. Translation: AAI26105.1.
BC143866 mRNA. Translation: AAI43867.1.
U80741 mRNA. Translation: AAB91439.1.
AF515031 Genomic DNA. Translation: AAN03389.1.
AF515032 Genomic DNA. Translation: AAN03390.1.
AF515033 Genomic DNA. Translation: AAN03391.1.
AF515034 Genomic DNA. Translation: AAN03392.1.
AF515035 Genomic DNA. Translation: AAN03393.1.
AF515036 Genomic DNA. Translation: AAN03394.1.
AF515037 Genomic DNA. Translation: AAN03395.1.
AF515038 Genomic DNA. Translation: AAN03396.1.
AF515039 Genomic DNA. Translation: AAN03397.1.
AF515040 Genomic DNA. Translation: AAN03398.1.
AF515041 Genomic DNA. Translation: AAN03399.1.
AF515042 Genomic DNA. Translation: AAN03400.1.
AF515043 Genomic DNA. Translation: AAN03401.1.
AF515044 Genomic DNA. Translation: AAN03402.1.
AF515045 Genomic DNA. Translation: AAN03403.1.
AF515046 Genomic DNA. Translation: AAN03404.1.
AF515047 Genomic DNA. Translation: AAN03405.1.
AF515048 Genomic DNA. Translation: AAN03406.1.
AF515049 Genomic DNA. Translation: AAN03407.1.
AF515050 Genomic DNA. Translation: AAN03408.1.
CCDSiCCDS43635.1. [O15409-4]
CCDS55154.1. [O15409-9]
CCDS5760.1. [O15409-1]
CCDS5761.2. [O15409-6]
RefSeqiNP_001166237.1. NM_001172766.2.
NP_001166238.1. NM_001172767.2.
NP_055306.1. NM_014491.3. [O15409-1]
NP_683696.2. NM_148898.3. [O15409-4]
NP_683697.2. NM_148899.3. [O15409-6]
NP_683698.2. NM_148900.3. [O15409-9]
UniGeneiHs.282787.

Genome annotation databases

EnsembliENST00000350908; ENSP00000265436; ENSG00000128573. [O15409-1]
ENST00000360232; ENSP00000353367; ENSG00000128573. [O15409-6]
ENST00000378237; ENSP00000367482; ENSG00000128573. [O15409-7]
ENST00000393489; ENSP00000377129; ENSG00000128573. [O15409-2]
ENST00000393494; ENSP00000377132; ENSG00000128573. [O15409-1]
ENST00000403559; ENSP00000385069; ENSG00000128573. [O15409-9]
ENST00000408937; ENSP00000386200; ENSG00000128573. [O15409-4]
ENST00000412402; ENSP00000405470; ENSG00000128573. [O15409-8]
ENST00000441290; ENSP00000416825; ENSG00000128573. [O15409-8]
GeneIDi93986.
KEGGihsa:93986.
UCSCiuc003vgv.1. human. [O15409-7]
uc003vgw.3. human. [O15409-5]
uc003vgx.2. human. [O15409-1]
uc003vgz.3. human. [O15409-4]
uc003vhd.3. human. [O15409-6]
uc011kmu.2. human. [O15409-9]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Protein Spotlight

Talking heads - Issue 51 of October 2004

Wikipedia

FOXP2 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF337817 mRNA. Translation: AAL10762.1 .
AF467252 mRNA. Translation: AAM60762.1 .
AF467253 mRNA. Translation: AAM60763.1 .
AF467254 mRNA. Translation: AAM60764.1 .
AF467255 mRNA. Translation: AAM60765.1 .
AF467256 mRNA. Translation: AAM60766.1 .
AF467257 mRNA. Translation: AAM60767.1 .
AF493430 mRNA. Translation: AAM13672.1 .
AY144615 mRNA. Translation: AAN60016.1 .
AK131266 mRNA. Translation: BAD18444.1 . Sequence problems.
AK296957 mRNA. Translation: BAG59501.1 .
AC003992 Genomic DNA. Translation: AAS07399.1 .
AC020606 Genomic DNA. Translation: AAS07502.1 .
AC073626 Genomic DNA. No translation available.
AC074000 Genomic DNA. No translation available.
AC092148 Genomic DNA. No translation available.
AC092606 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24367.1 .
CH236947 Genomic DNA. Translation: EAL24369.1 .
CH471070 Genomic DNA. Translation: EAW83484.1 .
CH471070 Genomic DNA. Translation: EAW83486.1 .
BC126104 mRNA. Translation: AAI26105.1 .
BC143866 mRNA. Translation: AAI43867.1 .
U80741 mRNA. Translation: AAB91439.1 .
AF515031 Genomic DNA. Translation: AAN03389.1 .
AF515032 Genomic DNA. Translation: AAN03390.1 .
AF515033 Genomic DNA. Translation: AAN03391.1 .
AF515034 Genomic DNA. Translation: AAN03392.1 .
AF515035 Genomic DNA. Translation: AAN03393.1 .
AF515036 Genomic DNA. Translation: AAN03394.1 .
AF515037 Genomic DNA. Translation: AAN03395.1 .
AF515038 Genomic DNA. Translation: AAN03396.1 .
AF515039 Genomic DNA. Translation: AAN03397.1 .
AF515040 Genomic DNA. Translation: AAN03398.1 .
AF515041 Genomic DNA. Translation: AAN03399.1 .
AF515042 Genomic DNA. Translation: AAN03400.1 .
AF515043 Genomic DNA. Translation: AAN03401.1 .
AF515044 Genomic DNA. Translation: AAN03402.1 .
AF515045 Genomic DNA. Translation: AAN03403.1 .
AF515046 Genomic DNA. Translation: AAN03404.1 .
AF515047 Genomic DNA. Translation: AAN03405.1 .
AF515048 Genomic DNA. Translation: AAN03406.1 .
AF515049 Genomic DNA. Translation: AAN03407.1 .
AF515050 Genomic DNA. Translation: AAN03408.1 .
CCDSi CCDS43635.1. [O15409-4 ]
CCDS55154.1. [O15409-9 ]
CCDS5760.1. [O15409-1 ]
CCDS5761.2. [O15409-6 ]
RefSeqi NP_001166237.1. NM_001172766.2.
NP_001166238.1. NM_001172767.2.
NP_055306.1. NM_014491.3. [O15409-1 ]
NP_683696.2. NM_148898.3. [O15409-4 ]
NP_683697.2. NM_148899.3. [O15409-6 ]
NP_683698.2. NM_148900.3. [O15409-9 ]
UniGenei Hs.282787.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2A07 X-ray 1.90 F/G/H/I/J/K 502-594 [» ]
2AS5 X-ray 2.70 F/G 502-594 [» ]
ProteinModelPortali O15409.
SMRi O15409. Positions 351-409, 503-584.
ModBasei Search...

Protein-protein interaction databases

BioGridi 125073. 6 interactions.
DIPi DIP-29004N.
IntActi O15409. 1 interaction.

PTM databases

PhosphoSitei O15409.

Proteomic databases

MaxQBi O15409.
PaxDbi O15409.
PRIDEi O15409.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000350908 ; ENSP00000265436 ; ENSG00000128573 . [O15409-1 ]
ENST00000360232 ; ENSP00000353367 ; ENSG00000128573 . [O15409-6 ]
ENST00000378237 ; ENSP00000367482 ; ENSG00000128573 . [O15409-7 ]
ENST00000393489 ; ENSP00000377129 ; ENSG00000128573 . [O15409-2 ]
ENST00000393494 ; ENSP00000377132 ; ENSG00000128573 . [O15409-1 ]
ENST00000403559 ; ENSP00000385069 ; ENSG00000128573 . [O15409-9 ]
ENST00000408937 ; ENSP00000386200 ; ENSG00000128573 . [O15409-4 ]
ENST00000412402 ; ENSP00000405470 ; ENSG00000128573 . [O15409-8 ]
ENST00000441290 ; ENSP00000416825 ; ENSG00000128573 . [O15409-8 ]
GeneIDi 93986.
KEGGi hsa:93986.
UCSCi uc003vgv.1. human. [O15409-7 ]
uc003vgw.3. human. [O15409-5 ]
uc003vgx.2. human. [O15409-1 ]
uc003vgz.3. human. [O15409-4 ]
uc003vhd.3. human. [O15409-6 ]
uc011kmu.2. human. [O15409-9 ]

Organism-specific databases

CTDi 93986.
GeneCardsi GC07P113649.
HGNCi HGNC:13875. FOXP2.
HPAi CAB011488.
HPA000382.
HPA000383.
MIMi 602081. phenotype.
605317. gene.
neXtProti NX_O15409.
Orphaneti 251061. 7q31 microdeletion syndrome.
209908. Childhood apraxia of speech.
PharmGKBi PA28242.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000092089.
HOVERGENi HBG051657.
KOi K09409.
OMAi PETKLCV.
OrthoDBi EOG7M6D7G.
PhylomeDBi O15409.
TreeFami TF326978.

Miscellaneous databases

ChiTaRSi FOXP2. human.
EvolutionaryTracei O15409.
GeneWikii FOXP2.
GenomeRNAii 93986.
NextBioi 78260.
PROi O15409.
SOURCEi Search...

Gene expression databases

ArrayExpressi O15409.
Bgeei O15409.
Genevestigatori O15409.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
PROSITEi PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A forkhead-domain gene is mutated in a severe speech and language disorder."
    Lai C.S.L., Fisher S.E., Hurst J.A., Vargha-Khadem F., Monaco A.P.
    Nature 413:519-523(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANT SPCH1 HIS-553.
  2. "FOXP2: novel exons, splice variants, and CAG repeat length stability."
    Bruce H.A., Margolis R.L.
    Hum. Genet. 111:136-144(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), NUCLEOTIDE SEQUENCE [MRNA] OF 1-415 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 259-715 (ISOFORM 6), TISSUE SPECIFICITY.
    Tissue: Brain, Corpus striatum, Fetal brain and Frontal cortex.
  3. Vincent J.B., Scherer S.W.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
  4. Guo J.H., Chen L., Yu L.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 8 AND 9).
    Tissue: Tongue.
  6. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  10. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-304 (ISOFORM 1).
    Tissue: Brain cortex.
  11. "Molecular evolution of FOXP2, a gene involved in speech and language."
    Enard W., Przeworski M., Fisher S.E., Lai C.S.L., Wiebe V., Kitano T., Monaco A.P., Paeaebo S.
    Nature 418:869-872(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 113-329.
  12. "Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction."
    Teramitsu I., Kudo L.C., London S.E., Geschwind D.H., White S.A.
    J. Neurosci. 24:3152-3163(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiFOXP2_HUMAN
AccessioniPrimary (citable) accession number: O15409
Secondary accession number(s): A0AUV6
, A4D0U8, A6NNW4, B4DLD9, Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: July 9, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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