Reviewed, UniProtKB/Swiss-Prot O15409 (FOXP2_HUMAN)

Names and origin

Protein names

Recommended name:
    Forkhead box protein P2
Alternative name(s):
    CAG repeat protein 44
    Trinucleotide repeat-containing gene 10 protein

Gene names

Name:	FOXP2
Synonyms:	CAGH44, TNRC10

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	715 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language.
Subunit structure	Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 By similarity.
Subcellular location	Nucleus Probable.
Tissue specificity	Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. Ref.2
Developmental stage	Expressed in the brain at 15 and 22 weeks of gestation, with a pattern of strong cortical, basal ganglia, thalamic and cerebellar expression. Highly expressed in the head and tail of nucleus caudatus and putamen. Restricted expression within the globus pallidus, with high levels in the pars interna, which provides the principal source of output from the basal ganglia to the nucleus centrum medianum thalami (CM) and the major motor relay nuclei of the thalamus. In the thalamus, present in the CM and nucleus medialis dorsalis thalami. Lower levels are observed in the nuclei anterior thalami, dorsal and ventral, and the nucleus parafascicularis thalami. Expressed in the ventrobasal complex comprising the nucleus ventralis posterior lateralis/medialis. The ventral tier of the thalamus exhibits strong expression, including nuclei ventralis anterior, lateralis and posterior lateralis pars oralis. Also expressed in the nucleus subthalamicus bilaterally and in the nucleus ruber. Ref.9
Domain	The leucine-zipper is required for dimerization and transcriptional repression By similarity.
Involvement in disease	Defects in FOXP2 are the cause of speech-language disorder 1 (SPCH1) [MIM:602081]; also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Affected individuals have a severe impairment in the selection and sequencing of fine orofacial movements, which are necessary for articulation. They also show deficits in several facets of language processing (such as the ability to break up words into their constituent phonemes) and grammatical skills. Ref.1 A chromosomal aberration disrupting FOXP2 is a cause of severe speech and language impairment. Translocation t(5;7)(q22;q31.2).
Sequence similarities	Contains 1 C2H2-type zinc finger. Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement
Disease	Disease mutation
Domain	Coiled coil Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	caudate nucleus development Inferred from mutant phenotype. Source: UniProtKB putamen development Inferred from mutant phenotype. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: HPA
Molecular function	protein homodimerization activity Inferred from direct assay. Source: UniProtKB sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O15409-1)

Also known as: I;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O15409-3)

Also known as: II;

The sequence of this isoform is not available.

Isoform 3 (identifier: O15409-2)

Also known as: III; IV;

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Isoform 4 (identifier: O15409-4)

The sequence of this isoform differs from the canonical sequence as follows:
     86-86: Q → QELLPETKLCICGHSSGDGHPHNTFA

Isoform 5 (identifier: O15409-5)

The sequence of this isoform differs from the canonical sequence as follows:
     86-86: Q → QELLPETKLCICGHSSGDGHPHNTFA
     133-143: QQLQEFYKKQQ → VMWVTCFGVLA
     144-715: Missing.

Isoform 6 (identifier: O15409-6)

Also known as: FOXP2-S;

The sequence of this isoform differs from the canonical sequence as follows:
     423-432: LNLVSSVTMS → VSAYCFINSK
     433-715: Missing.

Isoform 7 (identifier: O15409-7)

The sequence of this isoform differs from the canonical sequence as follows:
     366-715: Missing.

Isoform 8 (identifier: O15409-8)

The sequence of this isoform differs from the canonical sequence as follows:
     87-87: V → P
     88-715: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 715

715

Forkhead box protein P2

PRO_0000091879

Regions

Domain

388 – 409

22

Leucine-zipper

Zinc finger

346 – 371

26

C2H2-type

DNA binding

504 – 594

91

Fork-head

Region

422 – 426

5

CTBP1-binding By similarity

Coiled coil

117 – 231

115

Potential

Coiled coil

376 – 409

34

Potential

Compositional bias

53 – 56

4

Poly-Gln

Compositional bias

123 – 126

4

Poly-Gln

Compositional bias

131 – 136

6

Poly-Gln

Compositional bias

152 – 191

40

Poly-Gln

Compositional bias

200 – 209

10

Poly-Gln

Compositional bias

223 – 231

9

Poly-Gln

Natural variations

Alternative sequence

1 – 92

92

Missing in isoform 3.

VSP_001558

Alternative sequence

86

1

Q → QELLPETKLCICGHSSGDGH PHNTFA in isoform 4 and isoform 5.

VSP_011532

Alternative sequence

87

1

V → P in isoform 8.

VSP_011533

Alternative sequence

88 – 715

628

Missing in isoform 8.

VSP_011534

Alternative sequence

133 – 143

11

QQLQEFYKKQQ → VMWVTCFGVLA in isoform 5.

VSP_011535

Alternative sequence

144 – 715

572

Missing in isoform 5.

VSP_011536

Alternative sequence

366 – 715

350

Missing in isoform 7.

VSP_011537

Alternative sequence

423 – 432

10

LNLVSSVTMS → VSAYCFINSK in isoform 6.

VSP_011538

Alternative sequence

433 – 715

283

Missing in isoform 6.

VSP_011539

Natural variant

553

1

R → H in SPCH1. Ref.1

VAR_012278

Experimental info

Sequence conflict

29

1

A → V in AAM60762. Ref.2

Sequence conflict

134

1

Q → H Ref.7

Sequence conflict

290 – 304

15

DLTTN…TSSNT → EEFPVQGPAAVCAGL Ref.7

Sequence conflict

414

1

S → L in AAM60766. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

715

Helix Strand Turn

Details...

Helix

509 – 517

9

Helix

527 – 537

11

Helix

539 – 541

3

Helix

545 – 558

14

Beta strand

562 – 567

6

Beta strand

570 – 575

6

Helix

577 – 580

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (I) [UniParc]. Last modified December 5, 2001. Version 2. Checksum: 4F9FBDB6D90516E0	FASTA	715	79,919
	10 20 30 40 50 60 MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL HLQQQQALQA 70 80 90 100 110 120 ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT PQQMQQILQQ QVLSPQQLQA 130 140 150 160 170 180 LLQQQQAVML QQQQLQEFYK KQQEQLHLQL LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 190 200 210 220 230 240 QQQQQQQQQQ QHPGKQAKEQ QQQQQQQQQL AAQQLVFQQQ LLQMQQLQQQ QHLLSLQRQG 250 260 270 280 290 300 LISIPPGQAA LPVQSLPQAG LSPAEIQQLW KEVTGVHSME DNGIKHGGLD LTTNNSSSTT 310 320 330 340 350 360 SSNTSKASPP ITHHSIVNGQ SSVLSARRDS SSHEETGASH TLYGHGVCKW PGCESICEDF 370 380 390 400 410 420 GQFLKHLNNE HALDDRSTAQ CRVQMQVVQQ LEIQLSKERE RLQAMMTHLH MRPSEPKPSP 430 440 450 460 470 480 KPLNLVSSVT MSKNMLETSP QSLPQTPTTP TAPVTPITQG PSVITPASVP NVGAIRRRHS 490 500 510 520 530 540 DKYNIPMSSE IAPNYEFYKN ADVRPPFTYA TLIRQAIMES SDRQLTLNEI YSWFTRTFAY 550 560 570 580 590 600 FRRNAATWKN AVRHNLSLHK CFVRVENVKG AVWTVDEVEY QKRRSQKITG SPTLVKNIPT 610 620 630 640 650 660 SLGYGAALNA SLQAALAESS LPLLSNPGLI NNASSGLLQA VHEDLNGSLD HIDSNGNSSP 670 680 690 700 710 GCSPQPHIHS IHVKEEPVIA EDEDCPMSLV TTANHSPELE DDREIEEEPL SEDLE
	Isoform 2 (II) (Sequence not available).	FASTA	–	–
	Isoform 3 (III) (IV). Checksum: F78EA67F33A3AE05	FASTA	623	70,104
	10 20 30 40 50 60 MMTPQVITPQ QMQQILQQQV LSPQQLQALL QQQQAVMLQQ QQLQEFYKKQ QEQLHLQLLQ 70 80 90 100 110 120 QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQH PGKQAKEQQQ QQQQQQQLAA 130 140 150 160 170 180 QQLVFQQQLL QMQQLQQQQH LLSLQRQGLI SIPPGQAALP VQSLPQAGLS PAEIQQLWKE 190 200 210 220 230 240 VTGVHSMEDN GIKHGGLDLT TNNSSSTTSS NTSKASPPIT HHSIVNGQSS VLSARRDSSS 250 260 270 280 290 300 HEETGASHTL YGHGVCKWPG CESICEDFGQ FLKHLNNEHA LDDRSTAQCR VQMQVVQQLE 310 320 330 340 350 360 IQLSKERERL QAMMTHLHMR PSEPKPSPKP LNLVSSVTMS KNMLETSPQS LPQTPTTPTA 370 380 390 400 410 420 PVTPITQGPS VITPASVPNV GAIRRRHSDK YNIPMSSEIA PNYEFYKNAD VRPPFTYATL 430 440 450 460 470 480 IRQAIMESSD RQLTLNEIYS WFTRTFAYFR RNAATWKNAV RHNLSLHKCF VRVENVKGAV 490 500 510 520 530 540 WTVDEVEYQK RRSQKITGSP TLVKNIPTSL GYGAALNASL QAALAESSLP LLSNPGLINN 550 560 570 580 590 600 ASSGLLQAVH EDLNGSLDHI DSNGNSSPGC SPQPHIHSIH VKEEPVIAED EDCPMSLVTT 610 620 ANHSPELEDD REIEEEPLSE DLE
	Isoform 4. Checksum: 423EC421368FCD94	FASTA	740	82,565
	10 20 30 40 50 60 MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL HLQQQQALQA 70 80 90 100 110 120 ARQLLLQQQT SGLKSPKSSD KQRPLQELLP ETKLCICGHS SGDGHPHNTF AVPVSVAMMT 130 140 150 160 170 180 PQVITPQQMQ QILQQQVLSP QQLQALLQQQ QAVMLQQQQL QEFYKKQQEQ LHLQLLQQQQ 190 200 210 220 230 240 QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQHPGK QAKEQQQQQQ QQQQLAAQQL 250 260 270 280 290 300 VFQQQLLQMQ QLQQQQHLLS LQRQGLISIP PGQAALPVQS LPQAGLSPAE IQQLWKEVTG 310 320 330 340 350 360 VHSMEDNGIK HGGLDLTTNN SSSTTSSNTS KASPPITHHS IVNGQSSVLS ARRDSSSHEE 370 380 390 400 410 420 TGASHTLYGH GVCKWPGCES ICEDFGQFLK HLNNEHALDD RSTAQCRVQM QVVQQLEIQL 430 440 450 460 470 480 SKERERLQAM MTHLHMRPSE PKPSPKPLNL VSSVTMSKNM LETSPQSLPQ TPTTPTAPVT 490 500 510 520 530 540 PITQGPSVIT PASVPNVGAI RRRHSDKYNI PMSSEIAPNY EFYKNADVRP PFTYATLIRQ 550 560 570 580 590 600 AIMESSDRQL TLNEIYSWFT RTFAYFRRNA ATWKNAVRHN LSLHKCFVRV ENVKGAVWTV 610 620 630 640 650 660 DEVEYQKRRS QKITGSPTLV KNIPTSLGYG AALNASLQAA LAESSLPLLS NPGLINNASS 670 680 690 700 710 720 GLLQAVHEDL NGSLDHIDSN GNSSPGCSPQ PHIHSIHVKE EPVIAEDEDC PMSLVTTANH 730 740 SPELEDDREI EEEPLSEDLE
	Isoform 5. Checksum: 61B297B4D64BC670	FASTA	168	18,315
	10 20 30 40 50 60 MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL HLQQQQALQA 70 80 90 100 110 120 ARQLLLQQQT SGLKSPKSSD KQRPLQELLP ETKLCICGHS SGDGHPHNTF AVPVSVAMMT 130 140 150 160 PQVITPQQMQ QILQQQVLSP QQLQALLQQQ QAVMLQQVMW VTCFGVLA
	Isoform 6 (FOXP2-S). Checksum: 42BC7890ACAF498C	FASTA	432	48,764
	10 20 30 40 50 60 MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL HLQQQQALQA 70 80 90 100 110 120 ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT PQQMQQILQQ QVLSPQQLQA 130 140 150 160 170 180 LLQQQQAVML QQQQLQEFYK KQQEQLHLQL LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 190 200 210 220 230 240 QQQQQQQQQQ QHPGKQAKEQ QQQQQQQQQL AAQQLVFQQQ LLQMQQLQQQ QHLLSLQRQG 250 260 270 280 290 300 LISIPPGQAA LPVQSLPQAG LSPAEIQQLW KEVTGVHSME DNGIKHGGLD LTTNNSSSTT 310 320 330 340 350 360 SSNTSKASPP ITHHSIVNGQ SSVLSARRDS SSHEETGASH TLYGHGVCKW PGCESICEDF 370 380 390 400 410 420 GQFLKHLNNE HALDDRSTAQ CRVQMQVVQQ LEIQLSKERE RLQAMMTHLH MRPSEPKPSP 430 KPVSAYCFIN SK
	Isoform 7. Checksum: 0B052282E2E30771	FASTA	365	40,969
	10 20 30 40 50 60 MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL HLQQQQALQA 70 80 90 100 110 120 ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT PQQMQQILQQ QVLSPQQLQA 130 140 150 160 170 180 LLQQQQAVML QQQQLQEFYK KQQEQLHLQL LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 190 200 210 220 230 240 QQQQQQQQQQ QHPGKQAKEQ QQQQQQQQQL AAQQLVFQQQ LLQMQQLQQQ QHLLSLQRQG 250 260 270 280 290 300 LISIPPGQAA LPVQSLPQAG LSPAEIQQLW KEVTGVHSME DNGIKHGGLD LTTNNSSSTT 310 320 330 340 350 360 SSNTSKASPP ITHHSIVNGQ SSVLSARRDS SSHEETGASH TLYGHGVCKW PGCESICEDF GQFLK
	Isoform 8. Checksum: 624274B876E062E4	FASTA	87	9,377
	10 20 30 40 50 60 MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL HLQQQQALQA 70 80 ARQLLLQQQT SGLKSPKSSD KQRPLQP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A forkhead-domain gene is mutated in a severe speech and language disorder." Lai C.S.L., Fisher S.E., Hurst J.A., Vargha-Khadem F., Monaco A.P. Nature 413:519-523(2001) [PubMed: 11586359] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANT SPCH1 HIS-553.
[2]	"FOXP2: novel exons, splice variants, and CAG repeat length stability." Bruce H.A., Margolis R.L. Hum. Genet. 111:136-144(2002) [PubMed: 12189486] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), NUCLEOTIDE SEQUENCE [MRNA] OF 1-415 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 259-715 (ISOFORM 6), TISSUE SPECIFICITY. Tissue: Brain, Corpus striatum, Fetal brain and Frontal cortex.
[3]	Vincent J.B., Scherer S.W. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
[4]	Guo J.H., Chen L., Yu L. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8). Tissue: Tongue.
[6]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"cDNAs with long CAG trinucleotide repeats from human brain." Margolis R.L., Abraham M.R., Gatchell S.B., Li S.-H., Kidwai A.S., Breschel T.S., Stine O.C., Callahan C., McInnis M.G., Ross C.A. Hum. Genet. 100:114-122(1997) [PubMed: 9225980] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-304 (ISOFORM 1). Tissue: Brain cortex.
[8]	"Molecular evolution of FOXP2, a gene involved in speech and language." Enard W., Przeworski M., Fisher S.E., Lai C.S.L., Wiebe V., Kitano T., Monaco A.P., Paeaebo S. Nature 418:869-872(2002) [PubMed: 12192408] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 113-329.
[9]	"Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction." Teramitsu I., Kudo L.C., London S.E., Geschwind D.H., White S.A. J. Neurosci. 24:3152-3163(2004) [PubMed: 15056695] [Abstract] Cited for: DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

Talking heads - Issue 51 of October 2004

GeneReviews

Wikipedia

FOXP2 entry

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF337817 mRNA. Translation: AAL10762.1.
AF467252 mRNA. Translation: AAM60762.1.
AF467253 mRNA. Translation: AAM60763.1.
AF467254 mRNA. Translation: AAM60764.1.
AF467255 mRNA. Translation: AAM60765.1.
AF467256 mRNA. Translation: AAM60766.1.
AF467257 mRNA. Translation: AAM60767.1.
AF493430 mRNA. Translation: AAM13672.1.
AY144615 mRNA. Translation: AAN60016.1.
AK131266 mRNA. Translation: BAD18444.1. Sequence problems.
AC003992 Genomic DNA. Translation: AAS07399.1.
AC020606 Genomic DNA. Translation: AAS07502.1.
AC073626 Genomic DNA. No translation available.
U80741 mRNA. Translation: AAB91439.1.
AF515031 Genomic DNA. Translation: AAN03389.1.
AF515032 Genomic DNA. Translation: AAN03390.1.
AF515033 Genomic DNA. Translation: AAN03391.1.
AF515034 Genomic DNA. Translation: AAN03392.1.
AF515035 Genomic DNA. Translation: AAN03393.1.
AF515036 Genomic DNA. Translation: AAN03394.1.
AF515037 Genomic DNA. Translation: AAN03395.1.
AF515038 Genomic DNA. Translation: AAN03396.1.
AF515039 Genomic DNA. Translation: AAN03397.1.
AF515040 Genomic DNA. Translation: AAN03398.1.
AF515041 Genomic DNA. Translation: AAN03399.1.
AF515042 Genomic DNA. Translation: AAN03400.1.
AF515043 Genomic DNA. Translation: AAN03401.1.
AF515044 Genomic DNA. Translation: AAN03402.1.
AF515045 Genomic DNA. Translation: AAN03403.1.
AF515046 Genomic DNA. Translation: AAN03404.1.
AF515047 Genomic DNA. Translation: AAN03405.1.
AF515048 Genomic DNA. Translation: AAN03406.1.
AF515049 Genomic DNA. Translation: AAN03407.1.
AF515050 Genomic DNA. Translation: AAN03408.1.

IPI

IPI00215632.
IPI00288960.
IPI00382947.
IPI00383604.
IPI00454591.
IPI00454592.
IPI00879217.

RefSeq

NP_055306.1.
NP_683696.2.

UniGene

Hs.656280

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2A07	X-ray	1.90	F/G/H/I/J/K	503-594	[»]
2AS5	X-ray	2.70	F/G	503-594	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:29004N.

Proteomic databases

PRIDE

O15409.

Genome annotation databases

Ensembl

ENSG00000128573. Homo sapiens. [Contig view]

GeneID

93986.

KEGG

hsa:93986.

UCSC

uc003vgw.2. human.
uc003vgx.2. human.
uc003vgz.2. human.
uc003vhb.2. human.
uc003vhd.2. human.

Organism-specific databases

GeneCards

GC07P113842.

H-InvDB

HIX0033530.

HGNC

HGNC:13875. FOXP2.

HPA

CAB011488.
HPA000382.
HPA000383.

MIM

602081. phenotype.
605317. gene.

PharmGKB

PA28242.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

O15409.

OMA

O15409. NIPMSSE.

Gene expression databases

ArrayExpress

O15409.

Bgee

O15409.

GermOnline

ENSG00000128573. Homo sapiens.

Family and domain databases

InterPro

IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. Wing_hlx_DNA_bd.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]

Gene3D

G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.

PANTHER

PTHR11829. Fork_box_protein. 1 hit.

Pfam

PF00250. Fork_head. 1 hit.
[Graphical view]

PRINTS

PR00053. FORKHEAD.

ProDom

PD000425. TF_Fork_head. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]

PROSITE

PS00657. FORK_HEAD_1. False negative.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. False negative.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

78260.

SOURCE

Search...

Entry information

Entry name

FOXP2_HUMAN

Accession

Primary (citable) accession number: O15409
Secondary accession number(s): A6NNW4 , Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	December 5, 2001
Last modified:	July 7, 2009
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)