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O15409

- FOXP2_HUMAN

UniProt

O15409 - FOXP2_HUMAN

Protein

Forkhead box protein P2

Gene

FOXP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 2 (05 Dec 2001)
      Previous versions | rss
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    Functioni

    Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri346 – 37126C2H2-typeAdd
    BLAST
    DNA bindingi504 – 59491Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. protein homodimerization activity Source: UniProtKB
    4. sequence-specific DNA binding Source: BHF-UCL
    5. sequence-specific DNA binding transcription factor activity Source: BHF-UCL

    GO - Biological processi

    1. camera-type eye development Source: Ensembl
    2. caudate nucleus development Source: UniProtKB
    3. cerebellum development Source: Ensembl
    4. cerebral cortex development Source: BHF-UCL
    5. embryo development Source: Ensembl
    6. growth Source: Ensembl
    7. lung alveolus development Source: Ensembl
    8. negative regulation of transcription, DNA-templated Source: BHF-UCL
    9. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
    10. positive regulation of mesenchymal cell proliferation Source: Ensembl
    11. post-embryonic development Source: Ensembl
    12. putamen development Source: UniProtKB
    13. righting reflex Source: Ensembl
    14. skeletal muscle tissue development Source: Ensembl
    15. smooth muscle tissue development Source: Ensembl
    16. transcription, DNA-templated Source: UniProtKB-KW
    17. vocal learning Source: Ensembl

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein P2
    Alternative name(s):
    CAG repeat protein 44
    Trinucleotide repeat-containing gene 10 protein
    Gene namesi
    Name:FOXP2
    Synonyms:CAGH44, TNRC10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:13875. FOXP2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Speech-language disorder 1 (SPCH1) [MIM:602081]: A disorder characterized by severe orofacial dyspraxia resulting in largely incomprehensible speech. Affected individuals have severe impairment in the selection and sequencing of fine orofacial movements which are necessary for articulation, and deficits in several facets of grammatical skills and language processing, such as the ability to break up words into their constituent phonemes.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti553 – 5531R → H in SPCH1. 1 Publication
    VAR_012278
    A chromosomal aberration involving FOXP2 is a cause of severe speech and language impairment. Translocation t(5;7)(q22;q31.2).

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi602081. phenotype.
    Orphaneti251061. 7q31 microdeletion syndrome.
    209908. Childhood apraxia of speech.
    PharmGKBiPA28242.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 715715Forkhead box protein P2PRO_0000091879Add
    BLAST

    Proteomic databases

    MaxQBiO15409.
    PaxDbiO15409.
    PRIDEiO15409.

    PTM databases

    PhosphoSiteiO15409.

    Expressioni

    Tissue specificityi

    Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung.1 Publication

    Developmental stagei

    Expressed in the brain at 15 and 22 weeks of gestation, with a pattern of strong cortical, basal ganglia, thalamic and cerebellar expression. Highly expressed in the head and tail of nucleus caudatus and putamen. Restricted expression within the globus pallidus, with high levels in the pars interna, which provides the principal source of output from the basal ganglia to the nucleus centrum medianum thalami (CM) and the major motor relay nuclei of the thalamus. In the thalamus, present in the CM and nucleus medialis dorsalis thalami. Lower levels are observed in the nuclei anterior thalami, dorsal and ventral, and the nucleus parafascicularis thalami. Expressed in the ventrobasal complex comprising the nucleus ventralis posterior lateralis/medialis. The ventral tier of the thalamus exhibits strong expression, including nuclei ventralis anterior, lateralis and posterior lateralis pars oralis. Also expressed in the nucleus subthalamicus bilaterally and in the nucleus ruber.1 Publication

    Gene expression databases

    ArrayExpressiO15409.
    BgeeiO15409.
    GenevestigatoriO15409.

    Organism-specific databases

    HPAiCAB011488.
    HPA000382.
    HPA000383.

    Interactioni

    Subunit structurei

    Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi125073. 6 interactions.
    DIPiDIP-29004N.
    IntActiO15409. 1 interaction.

    Structurei

    Secondary structure

    1
    715
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi509 – 51911
    Helixi527 – 54115
    Helixi545 – 55814
    Beta strandi562 – 5676
    Beta strandi568 – 5725
    Helixi577 – 5837

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2A07X-ray1.90F/G/H/I/J/K502-594[»]
    2AS5X-ray2.70F/G502-594[»]
    ProteinModelPortaliO15409.
    SMRiO15409. Positions 351-409, 503-584.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO15409.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni388 – 40922Leucine-zipperAdd
    BLAST
    Regioni422 – 4265CTBP1-bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi53 – 268216Gln-richAdd
    BLAST

    Domaini

    The leucine-zipper is required for dimerization and transcriptional repression.By similarity

    Sequence similaritiesi

    Contains 1 C2H2-type zinc finger.Curated
    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri346 – 37126C2H2-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000092089.
    HOVERGENiHBG051657.
    KOiK09409.
    OMAiPETKLCV.
    OrthoDBiEOG7M6D7G.
    PhylomeDBiO15409.
    TreeFamiTF326978.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    PROSITEiPS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view]

    Sequences (9)i

    Sequence statusi: Complete.

    This entry describes 9 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O15409-1) [UniParc]FASTAAdd to Basket

    Also known as: I

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL    50
    HLQQQQALQA ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT 100
    PQQMQQILQQ QVLSPQQLQA LLQQQQAVML QQQQLQEFYK KQQEQLHLQL 150
    LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QHPGKQAKEQ 200
    QQQQQQQQQL AAQQLVFQQQ LLQMQQLQQQ QHLLSLQRQG LISIPPGQAA 250
    LPVQSLPQAG LSPAEIQQLW KEVTGVHSME DNGIKHGGLD LTTNNSSSTT 300
    SSNTSKASPP ITHHSIVNGQ SSVLSARRDS SSHEETGASH TLYGHGVCKW 350
    PGCESICEDF GQFLKHLNNE HALDDRSTAQ CRVQMQVVQQ LEIQLSKERE 400
    RLQAMMTHLH MRPSEPKPSP KPLNLVSSVT MSKNMLETSP QSLPQTPTTP 450
    TAPVTPITQG PSVITPASVP NVGAIRRRHS DKYNIPMSSE IAPNYEFYKN 500
    ADVRPPFTYA TLIRQAIMES SDRQLTLNEI YSWFTRTFAY FRRNAATWKN 550
    AVRHNLSLHK CFVRVENVKG AVWTVDEVEY QKRRSQKITG SPTLVKNIPT 600
    SLGYGAALNA SLQAALAESS LPLLSNPGLI NNASSGLLQA VHEDLNGSLD 650
    HIDSNGNSSP GCSPQPHIHS IHVKEEPVIA EDEDCPMSLV TTANHSPELE 700
    DDREIEEEPL SEDLE 715
    Length:715
    Mass (Da):79,919
    Last modified:December 5, 2001 - v2
    Checksum:i4F9FBDB6D90516E0
    GO
    Isoform 2 (identifier: O15409-3)

    Also known as: II

    Sequence is not available
    Length:
    Mass (Da):
    Isoform 3 (identifier: O15409-2) [UniParc]FASTAAdd to Basket

    Also known as: III, IV

    The sequence of this isoform differs from the canonical sequence as follows:
         1-92: Missing.

    Show »
    Length:623
    Mass (Da):70,104
    Checksum:iF78EA67F33A3AE05
    GO
    Isoform 4 (identifier: O15409-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         86-86: Q → QELLPETKLCICGHSSGDGHPHNTFA

    Show »
    Length:740
    Mass (Da):82,565
    Checksum:i423EC421368FCD94
    GO
    Isoform 5 (identifier: O15409-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         86-86: Q → QELLPETKLCICGHSSGDGHPHNTFA
         133-143: QQLQEFYKKQQ → VMWVTCFGVLA
         144-715: Missing.

    Show »
    Length:168
    Mass (Da):18,315
    Checksum:i61B297B4D64BC670
    GO
    Isoform 6 (identifier: O15409-6) [UniParc]FASTAAdd to Basket

    Also known as: FOXP2-S

    The sequence of this isoform differs from the canonical sequence as follows:
         423-432: LNLVSSVTMS → VSAYCFINSK
         433-715: Missing.

    Show »
    Length:432
    Mass (Da):48,764
    Checksum:i42BC7890ACAF498C
    GO
    Isoform 7 (identifier: O15409-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         366-715: Missing.

    Show »
    Length:365
    Mass (Da):40,969
    Checksum:i0B052282E2E30771
    GO
    Isoform 8 (identifier: O15409-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         87-87: V → P
         88-715: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:87
    Mass (Da):9,377
    Checksum:i624274B876E062E4
    GO
    Isoform 9 (identifier: O15409-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-132: Q → QDFLDSGLENFRAALEKN

    Note: No experimental confirmation available.

    Show »
    Length:732
    Mass (Da):81,840
    Checksum:i8B72F946ABD821EE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291A → V in AAM60762. (PubMed:12189486)Curated
    Sequence conflicti134 – 1341Q → H in AAB91439. (PubMed:9225980)Curated
    Sequence conflicti290 – 30415DLTTN…TSSNT → EEFPVQGPAAVCAGL in AAB91439. (PubMed:9225980)CuratedAdd
    BLAST
    Sequence conflicti414 – 4141S → L in AAM60766. (PubMed:12189486)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti553 – 5531R → H in SPCH1. 1 Publication
    VAR_012278

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9292Missing in isoform 3. 1 PublicationVSP_001558Add
    BLAST
    Alternative sequencei86 – 861Q → QELLPETKLCICGHSSGDGH PHNTFA in isoform 4 and isoform 5. 2 PublicationsVSP_011532
    Alternative sequencei87 – 871V → P in isoform 8. 1 PublicationVSP_011533
    Alternative sequencei88 – 715628Missing in isoform 8. 1 PublicationVSP_011534Add
    BLAST
    Alternative sequencei132 – 1321Q → QDFLDSGLENFRAALEKN in isoform 9. 1 PublicationVSP_043464
    Alternative sequencei133 – 14311QQLQEFYKKQQ → VMWVTCFGVLA in isoform 5. 1 PublicationVSP_011535Add
    BLAST
    Alternative sequencei144 – 715572Missing in isoform 5. 1 PublicationVSP_011536Add
    BLAST
    Alternative sequencei366 – 715350Missing in isoform 7. 1 PublicationVSP_011537Add
    BLAST
    Alternative sequencei423 – 43210LNLVSSVTMS → VSAYCFINSK in isoform 6. 1 PublicationVSP_011538
    Alternative sequencei433 – 715283Missing in isoform 6. 1 PublicationVSP_011539Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF337817 mRNA. Translation: AAL10762.1.
    AF467252 mRNA. Translation: AAM60762.1.
    AF467253 mRNA. Translation: AAM60763.1.
    AF467254 mRNA. Translation: AAM60764.1.
    AF467255 mRNA. Translation: AAM60765.1.
    AF467256 mRNA. Translation: AAM60766.1.
    AF467257 mRNA. Translation: AAM60767.1.
    AF493430 mRNA. Translation: AAM13672.1.
    AY144615 mRNA. Translation: AAN60016.1.
    AK131266 mRNA. Translation: BAD18444.1. Sequence problems.
    AK296957 mRNA. Translation: BAG59501.1.
    AC003992 Genomic DNA. Translation: AAS07399.1.
    AC020606 Genomic DNA. Translation: AAS07502.1.
    AC073626 Genomic DNA. No translation available.
    AC074000 Genomic DNA. No translation available.
    AC092148 Genomic DNA. No translation available.
    AC092606 Genomic DNA. No translation available.
    CH236947 Genomic DNA. Translation: EAL24367.1.
    CH236947 Genomic DNA. Translation: EAL24369.1.
    CH471070 Genomic DNA. Translation: EAW83484.1.
    CH471070 Genomic DNA. Translation: EAW83486.1.
    BC126104 mRNA. Translation: AAI26105.1.
    BC143866 mRNA. Translation: AAI43867.1.
    U80741 mRNA. Translation: AAB91439.1.
    AF515031 Genomic DNA. Translation: AAN03389.1.
    AF515032 Genomic DNA. Translation: AAN03390.1.
    AF515033 Genomic DNA. Translation: AAN03391.1.
    AF515034 Genomic DNA. Translation: AAN03392.1.
    AF515035 Genomic DNA. Translation: AAN03393.1.
    AF515036 Genomic DNA. Translation: AAN03394.1.
    AF515037 Genomic DNA. Translation: AAN03395.1.
    AF515038 Genomic DNA. Translation: AAN03396.1.
    AF515039 Genomic DNA. Translation: AAN03397.1.
    AF515040 Genomic DNA. Translation: AAN03398.1.
    AF515041 Genomic DNA. Translation: AAN03399.1.
    AF515042 Genomic DNA. Translation: AAN03400.1.
    AF515043 Genomic DNA. Translation: AAN03401.1.
    AF515044 Genomic DNA. Translation: AAN03402.1.
    AF515045 Genomic DNA. Translation: AAN03403.1.
    AF515046 Genomic DNA. Translation: AAN03404.1.
    AF515047 Genomic DNA. Translation: AAN03405.1.
    AF515048 Genomic DNA. Translation: AAN03406.1.
    AF515049 Genomic DNA. Translation: AAN03407.1.
    AF515050 Genomic DNA. Translation: AAN03408.1.
    CCDSiCCDS43635.1. [O15409-4]
    CCDS55154.1. [O15409-9]
    CCDS5760.1. [O15409-1]
    CCDS5761.2. [O15409-6]
    RefSeqiNP_001166237.1. NM_001172766.2.
    NP_001166238.1. NM_001172767.2.
    NP_055306.1. NM_014491.3. [O15409-1]
    NP_683696.2. NM_148898.3. [O15409-4]
    NP_683697.2. NM_148899.3. [O15409-6]
    NP_683698.2. NM_148900.3. [O15409-9]
    UniGeneiHs.282787.

    Genome annotation databases

    EnsembliENST00000350908; ENSP00000265436; ENSG00000128573. [O15409-1]
    ENST00000360232; ENSP00000353367; ENSG00000128573. [O15409-6]
    ENST00000378237; ENSP00000367482; ENSG00000128573. [O15409-7]
    ENST00000393489; ENSP00000377129; ENSG00000128573. [O15409-2]
    ENST00000393494; ENSP00000377132; ENSG00000128573. [O15409-1]
    ENST00000403559; ENSP00000385069; ENSG00000128573. [O15409-9]
    ENST00000408937; ENSP00000386200; ENSG00000128573. [O15409-4]
    ENST00000412402; ENSP00000405470; ENSG00000128573. [O15409-8]
    ENST00000441290; ENSP00000416825; ENSG00000128573. [O15409-8]
    GeneIDi93986.
    KEGGihsa:93986.
    UCSCiuc003vgv.1. human. [O15409-7]
    uc003vgw.3. human. [O15409-5]
    uc003vgx.2. human. [O15409-1]
    uc003vgz.3. human. [O15409-4]
    uc003vhd.3. human. [O15409-6]
    uc011kmu.2. human. [O15409-9]

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Talking heads - Issue 51 of October 2004

    Wikipedia

    FOXP2 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF337817 mRNA. Translation: AAL10762.1 .
    AF467252 mRNA. Translation: AAM60762.1 .
    AF467253 mRNA. Translation: AAM60763.1 .
    AF467254 mRNA. Translation: AAM60764.1 .
    AF467255 mRNA. Translation: AAM60765.1 .
    AF467256 mRNA. Translation: AAM60766.1 .
    AF467257 mRNA. Translation: AAM60767.1 .
    AF493430 mRNA. Translation: AAM13672.1 .
    AY144615 mRNA. Translation: AAN60016.1 .
    AK131266 mRNA. Translation: BAD18444.1 . Sequence problems.
    AK296957 mRNA. Translation: BAG59501.1 .
    AC003992 Genomic DNA. Translation: AAS07399.1 .
    AC020606 Genomic DNA. Translation: AAS07502.1 .
    AC073626 Genomic DNA. No translation available.
    AC074000 Genomic DNA. No translation available.
    AC092148 Genomic DNA. No translation available.
    AC092606 Genomic DNA. No translation available.
    CH236947 Genomic DNA. Translation: EAL24367.1 .
    CH236947 Genomic DNA. Translation: EAL24369.1 .
    CH471070 Genomic DNA. Translation: EAW83484.1 .
    CH471070 Genomic DNA. Translation: EAW83486.1 .
    BC126104 mRNA. Translation: AAI26105.1 .
    BC143866 mRNA. Translation: AAI43867.1 .
    U80741 mRNA. Translation: AAB91439.1 .
    AF515031 Genomic DNA. Translation: AAN03389.1 .
    AF515032 Genomic DNA. Translation: AAN03390.1 .
    AF515033 Genomic DNA. Translation: AAN03391.1 .
    AF515034 Genomic DNA. Translation: AAN03392.1 .
    AF515035 Genomic DNA. Translation: AAN03393.1 .
    AF515036 Genomic DNA. Translation: AAN03394.1 .
    AF515037 Genomic DNA. Translation: AAN03395.1 .
    AF515038 Genomic DNA. Translation: AAN03396.1 .
    AF515039 Genomic DNA. Translation: AAN03397.1 .
    AF515040 Genomic DNA. Translation: AAN03398.1 .
    AF515041 Genomic DNA. Translation: AAN03399.1 .
    AF515042 Genomic DNA. Translation: AAN03400.1 .
    AF515043 Genomic DNA. Translation: AAN03401.1 .
    AF515044 Genomic DNA. Translation: AAN03402.1 .
    AF515045 Genomic DNA. Translation: AAN03403.1 .
    AF515046 Genomic DNA. Translation: AAN03404.1 .
    AF515047 Genomic DNA. Translation: AAN03405.1 .
    AF515048 Genomic DNA. Translation: AAN03406.1 .
    AF515049 Genomic DNA. Translation: AAN03407.1 .
    AF515050 Genomic DNA. Translation: AAN03408.1 .
    CCDSi CCDS43635.1. [O15409-4 ]
    CCDS55154.1. [O15409-9 ]
    CCDS5760.1. [O15409-1 ]
    CCDS5761.2. [O15409-6 ]
    RefSeqi NP_001166237.1. NM_001172766.2.
    NP_001166238.1. NM_001172767.2.
    NP_055306.1. NM_014491.3. [O15409-1 ]
    NP_683696.2. NM_148898.3. [O15409-4 ]
    NP_683697.2. NM_148899.3. [O15409-6 ]
    NP_683698.2. NM_148900.3. [O15409-9 ]
    UniGenei Hs.282787.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2A07 X-ray 1.90 F/G/H/I/J/K 502-594 [» ]
    2AS5 X-ray 2.70 F/G 502-594 [» ]
    ProteinModelPortali O15409.
    SMRi O15409. Positions 351-409, 503-584.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125073. 6 interactions.
    DIPi DIP-29004N.
    IntActi O15409. 1 interaction.

    PTM databases

    PhosphoSitei O15409.

    Proteomic databases

    MaxQBi O15409.
    PaxDbi O15409.
    PRIDEi O15409.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000350908 ; ENSP00000265436 ; ENSG00000128573 . [O15409-1 ]
    ENST00000360232 ; ENSP00000353367 ; ENSG00000128573 . [O15409-6 ]
    ENST00000378237 ; ENSP00000367482 ; ENSG00000128573 . [O15409-7 ]
    ENST00000393489 ; ENSP00000377129 ; ENSG00000128573 . [O15409-2 ]
    ENST00000393494 ; ENSP00000377132 ; ENSG00000128573 . [O15409-1 ]
    ENST00000403559 ; ENSP00000385069 ; ENSG00000128573 . [O15409-9 ]
    ENST00000408937 ; ENSP00000386200 ; ENSG00000128573 . [O15409-4 ]
    ENST00000412402 ; ENSP00000405470 ; ENSG00000128573 . [O15409-8 ]
    ENST00000441290 ; ENSP00000416825 ; ENSG00000128573 . [O15409-8 ]
    GeneIDi 93986.
    KEGGi hsa:93986.
    UCSCi uc003vgv.1. human. [O15409-7 ]
    uc003vgw.3. human. [O15409-5 ]
    uc003vgx.2. human. [O15409-1 ]
    uc003vgz.3. human. [O15409-4 ]
    uc003vhd.3. human. [O15409-6 ]
    uc011kmu.2. human. [O15409-9 ]

    Organism-specific databases

    CTDi 93986.
    GeneCardsi GC07P113649.
    HGNCi HGNC:13875. FOXP2.
    HPAi CAB011488.
    HPA000382.
    HPA000383.
    MIMi 602081. phenotype.
    605317. gene.
    neXtProti NX_O15409.
    Orphaneti 251061. 7q31 microdeletion syndrome.
    209908. Childhood apraxia of speech.
    PharmGKBi PA28242.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000092089.
    HOVERGENi HBG051657.
    KOi K09409.
    OMAi PETKLCV.
    OrthoDBi EOG7M6D7G.
    PhylomeDBi O15409.
    TreeFami TF326978.

    Miscellaneous databases

    ChiTaRSi FOXP2. human.
    EvolutionaryTracei O15409.
    GeneWikii FOXP2.
    GenomeRNAii 93986.
    NextBioi 78260.
    PROi O15409.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15409.
    Bgeei O15409.
    Genevestigatori O15409.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    PROSITEi PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A forkhead-domain gene is mutated in a severe speech and language disorder."
      Lai C.S.L., Fisher S.E., Hurst J.A., Vargha-Khadem F., Monaco A.P.
      Nature 413:519-523(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANT SPCH1 HIS-553.
    2. "FOXP2: novel exons, splice variants, and CAG repeat length stability."
      Bruce H.A., Margolis R.L.
      Hum. Genet. 111:136-144(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), NUCLEOTIDE SEQUENCE [MRNA] OF 1-415 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 259-715 (ISOFORM 6), TISSUE SPECIFICITY.
      Tissue: Brain, Corpus striatum, Fetal brain and Frontal cortex.
    3. Vincent J.B., Scherer S.W.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    4. Guo J.H., Chen L., Yu L.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Brain.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 8 AND 9).
      Tissue: Tongue.
    6. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    10. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-304 (ISOFORM 1).
      Tissue: Brain cortex.
    11. "Molecular evolution of FOXP2, a gene involved in speech and language."
      Enard W., Przeworski M., Fisher S.E., Lai C.S.L., Wiebe V., Kitano T., Monaco A.P., Paeaebo S.
      Nature 418:869-872(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 113-329.
    12. "Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction."
      Teramitsu I., Kudo L.C., London S.E., Geschwind D.H., White S.A.
      J. Neurosci. 24:3152-3163(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiFOXP2_HUMAN
    AccessioniPrimary (citable) accession number: O15409
    Secondary accession number(s): A0AUV6
    , A4D0U8, A6NNW4, B4DLD9, Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: December 5, 2001
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3