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Protein

Forkhead box protein P2

Gene

FOXP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri346 – 37126C2H2-typeAdd
BLAST
DNA bindingi504 – 59491Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. protein homodimerization activity Source: UniProtKB
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  6. sequence-specific DNA binding Source: BHF-UCL
  7. sequence-specific DNA binding transcription factor activity Source: BHF-UCL

GO - Biological processi

  1. camera-type eye development Source: Ensembl
  2. caudate nucleus development Source: UniProtKB
  3. cerebellum development Source: Ensembl
  4. cerebral cortex development Source: BHF-UCL
  5. growth Source: Ensembl
  6. lung alveolus development Source: Ensembl
  7. negative regulation of transcription, DNA-templated Source: BHF-UCL
  8. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
  9. positive regulation of mesenchymal cell proliferation Source: Ensembl
  10. post-embryonic development Source: Ensembl
  11. putamen development Source: UniProtKB
  12. righting reflex Source: Ensembl
  13. skeletal muscle tissue development Source: Ensembl
  14. smooth muscle tissue development Source: Ensembl
  15. vocal learning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P2
Alternative name(s):
CAG repeat protein 44
Trinucleotide repeat-containing gene 10 protein
Gene namesi
Name:FOXP2
Synonyms:CAGH44, TNRC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:13875. FOXP2.

Subcellular locationi

  1. Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Speech-language disorder 1 (SPCH1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by severe orofacial dyspraxia resulting in largely incomprehensible speech. Affected individuals have severe impairment in the selection and sequencing of fine orofacial movements which are necessary for articulation, and deficits in several facets of grammatical skills and language processing, such as the ability to break up words into their constituent phonemes.

See also OMIM:602081
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti553 – 5531R → H in SPCH1. 1 Publication
VAR_012278

A chromosomal aberration involving FOXP2 is a cause of severe speech and language impairment. Translocation t(5;7)(q22;q31.2).

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi602081. phenotype.
Orphaneti251061. 7q31 microdeletion syndrome.
209908. Childhood apraxia of speech.
PharmGKBiPA28242.

Polymorphism and mutation databases

BioMutaiFOXP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 715715Forkhead box protein P2PRO_0000091879Add
BLAST

Proteomic databases

MaxQBiO15409.
PaxDbiO15409.
PRIDEiO15409.

PTM databases

PhosphoSiteiO15409.

Expressioni

Tissue specificityi

Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung.1 Publication

Developmental stagei

Expressed in the brain at 15 and 22 weeks of gestation, with a pattern of strong cortical, basal ganglia, thalamic and cerebellar expression. Highly expressed in the head and tail of nucleus caudatus and putamen. Restricted expression within the globus pallidus, with high levels in the pars interna, which provides the principal source of output from the basal ganglia to the nucleus centrum medianum thalami (CM) and the major motor relay nuclei of the thalamus. In the thalamus, present in the CM and nucleus medialis dorsalis thalami. Lower levels are observed in the nuclei anterior thalami, dorsal and ventral, and the nucleus parafascicularis thalami. Expressed in the ventrobasal complex comprising the nucleus ventralis posterior lateralis/medialis. The ventral tier of the thalamus exhibits strong expression, including nuclei ventralis anterior, lateralis and posterior lateralis pars oralis. Also expressed in the nucleus subthalamicus bilaterally and in the nucleus ruber.1 Publication

Gene expression databases

BgeeiO15409.
ExpressionAtlasiO15409. baseline and differential.
GenevestigatoriO15409.

Organism-specific databases

HPAiCAB011488.
HPA000382.
HPA000383.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-983612,EBI-717810
CCNCP248633EBI-983612,EBI-395261
CTBP1Q13363-23EBI-983612,EBI-10171858
CTBP2P565453EBI-983612,EBI-741533
FAM124AQ86V423EBI-983612,EBI-744506
PIN1Q135263EBI-983612,EBI-714158
SDCBPO005603EBI-983612,EBI-727004
TSACCQ96A043EBI-983612,EBI-740411

Protein-protein interaction databases

BioGridi125073. 28 interactions.
DIPiDIP-29004N.
IntActiO15409. 9 interactions.

Structurei

Secondary structure

1
715
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi509 – 51911Combined sources
Helixi527 – 54115Combined sources
Helixi545 – 55814Combined sources
Beta strandi562 – 5676Combined sources
Beta strandi568 – 5725Combined sources
Helixi577 – 5837Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A07X-ray1.90F/G/H/I/J/K502-594[»]
2AS5X-ray2.70F/G502-594[»]
ProteinModelPortaliO15409.
SMRiO15409. Positions 351-409, 503-584.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15409.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni388 – 40922Leucine-zipperAdd
BLAST
Regioni422 – 4265CTBP1-bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi53 – 268216Gln-richAdd
BLAST

Domaini

The leucine-zipper is required for dimerization and transcriptional repression.By similarity

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.Curated
Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri346 – 37126C2H2-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00780000121840.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.
InParanoidiO15409.
KOiK09409.
OMAiPETKLCV.
OrthoDBiEOG7M6D7G.
PhylomeDBiO15409.
TreeFamiTF326978.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR011991. WHTH_DNA-bd_dom.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15409-1) [UniParc]FASTAAdd to basket

Also known as: I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL
60 70 80 90 100
HLQQQQALQA ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT
110 120 130 140 150
PQQMQQILQQ QVLSPQQLQA LLQQQQAVML QQQQLQEFYK KQQEQLHLQL
160 170 180 190 200
LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QHPGKQAKEQ
210 220 230 240 250
QQQQQQQQQL AAQQLVFQQQ LLQMQQLQQQ QHLLSLQRQG LISIPPGQAA
260 270 280 290 300
LPVQSLPQAG LSPAEIQQLW KEVTGVHSME DNGIKHGGLD LTTNNSSSTT
310 320 330 340 350
SSNTSKASPP ITHHSIVNGQ SSVLSARRDS SSHEETGASH TLYGHGVCKW
360 370 380 390 400
PGCESICEDF GQFLKHLNNE HALDDRSTAQ CRVQMQVVQQ LEIQLSKERE
410 420 430 440 450
RLQAMMTHLH MRPSEPKPSP KPLNLVSSVT MSKNMLETSP QSLPQTPTTP
460 470 480 490 500
TAPVTPITQG PSVITPASVP NVGAIRRRHS DKYNIPMSSE IAPNYEFYKN
510 520 530 540 550
ADVRPPFTYA TLIRQAIMES SDRQLTLNEI YSWFTRTFAY FRRNAATWKN
560 570 580 590 600
AVRHNLSLHK CFVRVENVKG AVWTVDEVEY QKRRSQKITG SPTLVKNIPT
610 620 630 640 650
SLGYGAALNA SLQAALAESS LPLLSNPGLI NNASSGLLQA VHEDLNGSLD
660 670 680 690 700
HIDSNGNSSP GCSPQPHIHS IHVKEEPVIA EDEDCPMSLV TTANHSPELE
710
DDREIEEEPL SEDLE
Length:715
Mass (Da):79,919
Last modified:December 5, 2001 - v2
Checksum:i4F9FBDB6D90516E0
GO
Isoform 2 (identifier: O15409-3)

Also known as: II

Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: O15409-2) [UniParc]FASTAAdd to basket

Also known as: III, IV

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:623
Mass (Da):70,104
Checksum:iF78EA67F33A3AE05
GO
Isoform 4 (identifier: O15409-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-86: Q → QELLPETKLCICGHSSGDGHPHNTFA

Show »
Length:740
Mass (Da):82,565
Checksum:i423EC421368FCD94
GO
Isoform 5 (identifier: O15409-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-86: Q → QELLPETKLCICGHSSGDGHPHNTFA
     133-143: QQLQEFYKKQQ → VMWVTCFGVLA
     144-715: Missing.

Show »
Length:168
Mass (Da):18,315
Checksum:i61B297B4D64BC670
GO
Isoform 6 (identifier: O15409-6) [UniParc]FASTAAdd to basket

Also known as: FOXP2-S

The sequence of this isoform differs from the canonical sequence as follows:
     423-432: LNLVSSVTMS → VSAYCFINSK
     433-715: Missing.

Show »
Length:432
Mass (Da):48,764
Checksum:i42BC7890ACAF498C
GO
Isoform 7 (identifier: O15409-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-715: Missing.

Show »
Length:365
Mass (Da):40,969
Checksum:i0B052282E2E30771
GO
Isoform 8 (identifier: O15409-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-87: V → P
     88-715: Missing.

Note: No experimental confirmation available.

Show »
Length:87
Mass (Da):9,377
Checksum:i624274B876E062E4
GO
Isoform 9 (identifier: O15409-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-132: Q → QDFLDSGLENFRAALEKN

Note: No experimental confirmation available.

Show »
Length:732
Mass (Da):81,840
Checksum:i8B72F946ABD821EE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291A → V in AAM60762 (PubMed:12189486).Curated
Sequence conflicti134 – 1341Q → H in AAB91439 (PubMed:9225980).Curated
Sequence conflicti290 – 30415DLTTN…TSSNT → EEFPVQGPAAVCAGL in AAB91439 (PubMed:9225980).CuratedAdd
BLAST
Sequence conflicti414 – 4141S → L in AAM60766 (PubMed:12189486).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti553 – 5531R → H in SPCH1. 1 Publication
VAR_012278

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9292Missing in isoform 3. 1 PublicationVSP_001558Add
BLAST
Alternative sequencei86 – 861Q → QELLPETKLCICGHSSGDGH PHNTFA in isoform 4 and isoform 5. 2 PublicationsVSP_011532
Alternative sequencei87 – 871V → P in isoform 8. 1 PublicationVSP_011533
Alternative sequencei88 – 715628Missing in isoform 8. 1 PublicationVSP_011534Add
BLAST
Alternative sequencei132 – 1321Q → QDFLDSGLENFRAALEKN in isoform 9. 1 PublicationVSP_043464
Alternative sequencei133 – 14311QQLQEFYKKQQ → VMWVTCFGVLA in isoform 5. 1 PublicationVSP_011535Add
BLAST
Alternative sequencei144 – 715572Missing in isoform 5. 1 PublicationVSP_011536Add
BLAST
Alternative sequencei366 – 715350Missing in isoform 7. 1 PublicationVSP_011537Add
BLAST
Alternative sequencei423 – 43210LNLVSSVTMS → VSAYCFINSK in isoform 6. 1 PublicationVSP_011538
Alternative sequencei433 – 715283Missing in isoform 6. 1 PublicationVSP_011539Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337817 mRNA. Translation: AAL10762.1.
AF467252 mRNA. Translation: AAM60762.1.
AF467253 mRNA. Translation: AAM60763.1.
AF467254 mRNA. Translation: AAM60764.1.
AF467255 mRNA. Translation: AAM60765.1.
AF467256 mRNA. Translation: AAM60766.1.
AF467257 mRNA. Translation: AAM60767.1.
AF493430 mRNA. Translation: AAM13672.1.
AY144615 mRNA. Translation: AAN60016.1.
AK131266 mRNA. Translation: BAD18444.1. Sequence problems.
AK296957 mRNA. Translation: BAG59501.1.
AC003992 Genomic DNA. Translation: AAS07399.1.
AC020606 Genomic DNA. Translation: AAS07502.1.
AC073626 Genomic DNA. No translation available.
AC074000 Genomic DNA. No translation available.
AC092148 Genomic DNA. No translation available.
AC092606 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24367.1.
CH236947 Genomic DNA. Translation: EAL24369.1.
CH471070 Genomic DNA. Translation: EAW83484.1.
CH471070 Genomic DNA. Translation: EAW83486.1.
BC126104 mRNA. Translation: AAI26105.1.
BC143866 mRNA. Translation: AAI43867.1.
U80741 mRNA. Translation: AAB91439.1.
AF515031 Genomic DNA. Translation: AAN03389.1.
AF515032 Genomic DNA. Translation: AAN03390.1.
AF515033 Genomic DNA. Translation: AAN03391.1.
AF515034 Genomic DNA. Translation: AAN03392.1.
AF515035 Genomic DNA. Translation: AAN03393.1.
AF515036 Genomic DNA. Translation: AAN03394.1.
AF515037 Genomic DNA. Translation: AAN03395.1.
AF515038 Genomic DNA. Translation: AAN03396.1.
AF515039 Genomic DNA. Translation: AAN03397.1.
AF515040 Genomic DNA. Translation: AAN03398.1.
AF515041 Genomic DNA. Translation: AAN03399.1.
AF515042 Genomic DNA. Translation: AAN03400.1.
AF515043 Genomic DNA. Translation: AAN03401.1.
AF515044 Genomic DNA. Translation: AAN03402.1.
AF515045 Genomic DNA. Translation: AAN03403.1.
AF515046 Genomic DNA. Translation: AAN03404.1.
AF515047 Genomic DNA. Translation: AAN03405.1.
AF515048 Genomic DNA. Translation: AAN03406.1.
AF515049 Genomic DNA. Translation: AAN03407.1.
AF515050 Genomic DNA. Translation: AAN03408.1.
CCDSiCCDS43635.1. [O15409-4]
CCDS55154.1. [O15409-9]
CCDS5760.1. [O15409-1]
CCDS5761.2. [O15409-6]
RefSeqiNP_001166237.1. NM_001172766.2.
NP_001166238.1. NM_001172767.2.
NP_055306.1. NM_014491.3. [O15409-1]
NP_683696.2. NM_148898.3. [O15409-4]
NP_683697.2. NM_148899.3. [O15409-6]
NP_683698.2. NM_148900.3. [O15409-9]
UniGeneiHs.282787.

Genome annotation databases

EnsembliENST00000350908; ENSP00000265436; ENSG00000128573. [O15409-1]
ENST00000360232; ENSP00000353367; ENSG00000128573. [O15409-6]
ENST00000378237; ENSP00000367482; ENSG00000128573. [O15409-7]
ENST00000393489; ENSP00000377129; ENSG00000128573. [O15409-2]
ENST00000393494; ENSP00000377132; ENSG00000128573. [O15409-1]
ENST00000403559; ENSP00000385069; ENSG00000128573. [O15409-9]
ENST00000408937; ENSP00000386200; ENSG00000128573. [O15409-4]
ENST00000412402; ENSP00000405470; ENSG00000128573. [O15409-8]
ENST00000441290; ENSP00000416825; ENSG00000128573. [O15409-8]
GeneIDi93986.
KEGGihsa:93986.
UCSCiuc003vgv.1. human. [O15409-7]
uc003vgw.3. human. [O15409-5]
uc003vgx.2. human. [O15409-1]
uc003vgz.3. human. [O15409-4]
uc003vhd.3. human. [O15409-6]
uc011kmu.2. human. [O15409-9]

Polymorphism and mutation databases

BioMutaiFOXP2.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Protein Spotlight

Talking heads - Issue 51 of October 2004

Wikipedia

FOXP2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337817 mRNA. Translation: AAL10762.1.
AF467252 mRNA. Translation: AAM60762.1.
AF467253 mRNA. Translation: AAM60763.1.
AF467254 mRNA. Translation: AAM60764.1.
AF467255 mRNA. Translation: AAM60765.1.
AF467256 mRNA. Translation: AAM60766.1.
AF467257 mRNA. Translation: AAM60767.1.
AF493430 mRNA. Translation: AAM13672.1.
AY144615 mRNA. Translation: AAN60016.1.
AK131266 mRNA. Translation: BAD18444.1. Sequence problems.
AK296957 mRNA. Translation: BAG59501.1.
AC003992 Genomic DNA. Translation: AAS07399.1.
AC020606 Genomic DNA. Translation: AAS07502.1.
AC073626 Genomic DNA. No translation available.
AC074000 Genomic DNA. No translation available.
AC092148 Genomic DNA. No translation available.
AC092606 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24367.1.
CH236947 Genomic DNA. Translation: EAL24369.1.
CH471070 Genomic DNA. Translation: EAW83484.1.
CH471070 Genomic DNA. Translation: EAW83486.1.
BC126104 mRNA. Translation: AAI26105.1.
BC143866 mRNA. Translation: AAI43867.1.
U80741 mRNA. Translation: AAB91439.1.
AF515031 Genomic DNA. Translation: AAN03389.1.
AF515032 Genomic DNA. Translation: AAN03390.1.
AF515033 Genomic DNA. Translation: AAN03391.1.
AF515034 Genomic DNA. Translation: AAN03392.1.
AF515035 Genomic DNA. Translation: AAN03393.1.
AF515036 Genomic DNA. Translation: AAN03394.1.
AF515037 Genomic DNA. Translation: AAN03395.1.
AF515038 Genomic DNA. Translation: AAN03396.1.
AF515039 Genomic DNA. Translation: AAN03397.1.
AF515040 Genomic DNA. Translation: AAN03398.1.
AF515041 Genomic DNA. Translation: AAN03399.1.
AF515042 Genomic DNA. Translation: AAN03400.1.
AF515043 Genomic DNA. Translation: AAN03401.1.
AF515044 Genomic DNA. Translation: AAN03402.1.
AF515045 Genomic DNA. Translation: AAN03403.1.
AF515046 Genomic DNA. Translation: AAN03404.1.
AF515047 Genomic DNA. Translation: AAN03405.1.
AF515048 Genomic DNA. Translation: AAN03406.1.
AF515049 Genomic DNA. Translation: AAN03407.1.
AF515050 Genomic DNA. Translation: AAN03408.1.
CCDSiCCDS43635.1. [O15409-4]
CCDS55154.1. [O15409-9]
CCDS5760.1. [O15409-1]
CCDS5761.2. [O15409-6]
RefSeqiNP_001166237.1. NM_001172766.2.
NP_001166238.1. NM_001172767.2.
NP_055306.1. NM_014491.3. [O15409-1]
NP_683696.2. NM_148898.3. [O15409-4]
NP_683697.2. NM_148899.3. [O15409-6]
NP_683698.2. NM_148900.3. [O15409-9]
UniGeneiHs.282787.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A07X-ray1.90F/G/H/I/J/K502-594[»]
2AS5X-ray2.70F/G502-594[»]
ProteinModelPortaliO15409.
SMRiO15409. Positions 351-409, 503-584.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125073. 28 interactions.
DIPiDIP-29004N.
IntActiO15409. 9 interactions.

PTM databases

PhosphoSiteiO15409.

Polymorphism and mutation databases

BioMutaiFOXP2.

Proteomic databases

MaxQBiO15409.
PaxDbiO15409.
PRIDEiO15409.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350908; ENSP00000265436; ENSG00000128573. [O15409-1]
ENST00000360232; ENSP00000353367; ENSG00000128573. [O15409-6]
ENST00000378237; ENSP00000367482; ENSG00000128573. [O15409-7]
ENST00000393489; ENSP00000377129; ENSG00000128573. [O15409-2]
ENST00000393494; ENSP00000377132; ENSG00000128573. [O15409-1]
ENST00000403559; ENSP00000385069; ENSG00000128573. [O15409-9]
ENST00000408937; ENSP00000386200; ENSG00000128573. [O15409-4]
ENST00000412402; ENSP00000405470; ENSG00000128573. [O15409-8]
ENST00000441290; ENSP00000416825; ENSG00000128573. [O15409-8]
GeneIDi93986.
KEGGihsa:93986.
UCSCiuc003vgv.1. human. [O15409-7]
uc003vgw.3. human. [O15409-5]
uc003vgx.2. human. [O15409-1]
uc003vgz.3. human. [O15409-4]
uc003vhd.3. human. [O15409-6]
uc011kmu.2. human. [O15409-9]

Organism-specific databases

CTDi93986.
GeneCardsiGC07P113649.
HGNCiHGNC:13875. FOXP2.
HPAiCAB011488.
HPA000382.
HPA000383.
MIMi602081. phenotype.
605317. gene.
neXtProtiNX_O15409.
Orphaneti251061. 7q31 microdeletion syndrome.
209908. Childhood apraxia of speech.
PharmGKBiPA28242.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00780000121840.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.
InParanoidiO15409.
KOiK09409.
OMAiPETKLCV.
OrthoDBiEOG7M6D7G.
PhylomeDBiO15409.
TreeFamiTF326978.

Miscellaneous databases

ChiTaRSiFOXP2. human.
EvolutionaryTraceiO15409.
GeneWikiiFOXP2.
GenomeRNAii93986.
NextBioi78260.
PROiO15409.
SOURCEiSearch...

Gene expression databases

BgeeiO15409.
ExpressionAtlasiO15409. baseline and differential.
GenevestigatoriO15409.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR011991. WHTH_DNA-bd_dom.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A forkhead-domain gene is mutated in a severe speech and language disorder."
    Lai C.S.L., Fisher S.E., Hurst J.A., Vargha-Khadem F., Monaco A.P.
    Nature 413:519-523(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANT SPCH1 HIS-553.
  2. "FOXP2: novel exons, splice variants, and CAG repeat length stability."
    Bruce H.A., Margolis R.L.
    Hum. Genet. 111:136-144(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), NUCLEOTIDE SEQUENCE [MRNA] OF 1-415 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 259-715 (ISOFORM 6), TISSUE SPECIFICITY.
    Tissue: Brain, Corpus striatum, Fetal brain and Frontal cortex.
  3. Vincent J.B., Scherer S.W.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
  4. Guo J.H., Chen L., Yu L.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 8 AND 9).
    Tissue: Tongue.
  6. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  10. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-304 (ISOFORM 1).
    Tissue: Brain cortex.
  11. "Molecular evolution of FOXP2, a gene involved in speech and language."
    Enard W., Przeworski M., Fisher S.E., Lai C.S.L., Wiebe V., Kitano T., Monaco A.P., Paeaebo S.
    Nature 418:869-872(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 113-329.
  12. "Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction."
    Teramitsu I., Kudo L.C., London S.E., Geschwind D.H., White S.A.
    J. Neurosci. 24:3152-3163(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiFOXP2_HUMAN
AccessioniPrimary (citable) accession number: O15409
Secondary accession number(s): A0AUV6
, A4D0U8, A6NNW4, B4DLD9, Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: April 29, 2015
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.