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O15405

- TOX3_HUMAN

UniProt

O15405 - TOX3_HUMAN

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Protein

TOX high mobility group box family member 3

Gene
TOX3, CAGF9, TNRC9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi255 – 32369HMG boxAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. estrogen response element binding Source: UniProtKB
  3. phosphoprotein binding Source: UniProtKB
  4. protein binding Source: UniProtKB
  5. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. negative regulation of neuron apoptotic process Source: UniProtKB
  3. positive regulation of transcription, DNA-templated Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TOX high mobility group box family member 3
Alternative name(s):
CAG trinucleotide repeat-containing gene F9 protein
Trinucleotide repeat-containing gene 9 protein
Gene namesi
Name:TOX3
Synonyms:CAGF9, TNRC9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:11972. TOX3.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406752.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576TOX high mobility group box family member 3PRO_0000286353Add
BLAST

Proteomic databases

MaxQBiO15405.
PaxDbiO15405.
PRIDEiO15405.

PTM databases

PhosphoSiteiO15405.

Expressioni

Tissue specificityi

Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe.1 Publication

Inductioni

Up-regulated by GPR39 in neuronal cells.1 Publication

Gene expression databases

ArrayExpressiO15405.
BgeeiO15405.
CleanExiHS_TOX3.
GenevestigatoriO15405.

Organism-specific databases

HPAiHPA040376.

Interactioni

Subunit structurei

Homodimer. Interacts with CREB1; the interaction is not depolarization dependent. Interacts with CREBBP (via C-terminus) By similarity. Interacts (via HGM box) with CITED1 (via C-terminus); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with CREB1 (phosphorylated form).1 Publication

Protein-protein interaction databases

BioGridi118139. 1 interaction.
IntActiO15405. 1 interaction.
MINTiMINT-2795739.
STRINGi9606.ENSP00000385705.

Structurei

3D structure databases

ProteinModelPortaliO15405.
SMRiO15405. Positions 219-335.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 354Poly-Asn
Compositional biasi245 – 2506Poly-Lys
Compositional biasi431 – 572142Gln-richAdd
BLAST

Domaini

the C-terminus is required for calcium responsiveness but not for transactivation activity By similarity.
The N-terminus is absolutely necessary for transactivation activity By similarity.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG284736.
HOGENOMiHOG000230949.
HOVERGENiHBG051183.
OMAiPMNQIVA.
OrthoDBiEOG7R834J.
PhylomeDBiO15405.
TreeFamiTF106481.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O15405-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDVRFYPAAA GDPASLDFAQ CLGYYGYSKF GNNNNYMNMA EANNAFFAAS    50
EQTFHTPSLG DEEFEIPPIT PPPESDPALG MPDVLLPFQA LSDPLPSQGS 100
EFTPQFPPQS LDLPSITISR NLVEQDGVLH SSGLHMDQSH TQVSQYRQDP 150
SLIMRSIVHM TDAARSGVMP PAQLTTINQS QLSAQLGLNL GGASMPHTSP 200
SPPASKSATP SPSSSINEED ADEANRAIGE KRAAPDSGKK PKTPKKKKKK 250
DPNEPQKPVS AYALFFRDTQ AAIKGQNPNA TFGEVSKIVA SMWDSLGEEQ 300
KQVYKRKTEA AKKEYLKALA AYRASLVSKA AAESAEAQTI RSVQQTLAST 350
NLTSSLLLNT PLSQHGTVSA SPQTLQQSLP RSIAPKPLTM RLPMNQIVTS 400
VTIAANMPSN IGAPLISSMG TTMVGSAPST QVSPSVQTQQ HQMQLQQQQQ 450
QQQQQMQQMQ QQQLQQHQMH QQIQQQMQQQ HFQHHMQQHL QQQQQHLQQQ 500
INQQQLQQQL QQRLQLQQLQ HMQHQSQPSP RQHSPVASQI TSPIPAIGSP 550
QPASQQHQSQ IQSQTQTQVL SQVSIF 576
Length:576
Mass (Da):63,342
Last modified:May 1, 2007 - v2
Checksum:i0CE15100A96E1478
GO
Isoform 2 (identifier: O15405-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MDVRFYPAAAGDPASLDFAQCLGYYGYS → MKCQPRSGARRIEERLHYLITTYL
     52-52: Missing.

Note: No experimental confirmation available.

Show »
Length:571
Mass (Da):63,100
Checksum:i4447F1086050C823
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti128 – 1281V → M.
Corresponds to variant rs16951186 [ dbSNP | Ensembl ].
VAR_055952
Natural varianti572 – 5721Q → P.
Corresponds to variant rs13332816 [ dbSNP | Ensembl ].
VAR_055953

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2828MDVRF…YYGYS → MKCQPRSGARRIEERLHYLI TTYL in isoform 2. VSP_043095Add
BLAST
Alternative sequencei52 – 521Missing in isoform 2. VSP_043096

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK299202 mRNA. Translation: BAG61242.1.
AC007490 Genomic DNA. No translation available.
U80736 mRNA. Translation: AAB91435.1.
CCDSiCCDS54008.1. [O15405-2]
CCDS54009.1. [O15405-1]
RefSeqiNP_001073899.2. NM_001080430.2. [O15405-1]
NP_001139660.1. NM_001146188.1. [O15405-2]
UniGeneiHs.460789.

Genome annotation databases

EnsembliENST00000219746; ENSP00000219746; ENSG00000103460. [O15405-1]
ENST00000407228; ENSP00000385705; ENSG00000103460. [O15405-2]
GeneIDi27324.
KEGGihsa:27324.
UCSCiuc002egw.2. human. [O15405-1]
uc010vgt.1. human. [O15405-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK299202 mRNA. Translation: BAG61242.1 .
AC007490 Genomic DNA. No translation available.
U80736 mRNA. Translation: AAB91435.1 .
CCDSi CCDS54008.1. [O15405-2 ]
CCDS54009.1. [O15405-1 ]
RefSeqi NP_001073899.2. NM_001080430.2. [O15405-1 ]
NP_001139660.1. NM_001146188.1. [O15405-2 ]
UniGenei Hs.460789.

3D structure databases

ProteinModelPortali O15405.
SMRi O15405. Positions 219-335.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118139. 1 interaction.
IntActi O15405. 1 interaction.
MINTi MINT-2795739.
STRINGi 9606.ENSP00000385705.

PTM databases

PhosphoSitei O15405.

Proteomic databases

MaxQBi O15405.
PaxDbi O15405.
PRIDEi O15405.

Protocols and materials databases

DNASUi 27324.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000219746 ; ENSP00000219746 ; ENSG00000103460 . [O15405-1 ]
ENST00000407228 ; ENSP00000385705 ; ENSG00000103460 . [O15405-2 ]
GeneIDi 27324.
KEGGi hsa:27324.
UCSCi uc002egw.2. human. [O15405-1 ]
uc010vgt.1. human. [O15405-2 ]

Organism-specific databases

CTDi 27324.
GeneCardsi GC16M052471.
H-InvDB HIX0013031.
HGNCi HGNC:11972. TOX3.
HPAi HPA040376.
MIMi 611416. gene.
neXtProti NX_O15405.
PharmGKBi PA162406752.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284736.
HOGENOMi HOG000230949.
HOVERGENi HBG051183.
OMAi PMNQIVA.
OrthoDBi EOG7R834J.
PhylomeDBi O15405.
TreeFami TF106481.

Miscellaneous databases

ChiTaRSi TOX3. human.
GenomeRNAii 27324.
NextBioi 50340.
PROi O15405.
SOURCEi Search...

Gene expression databases

ArrayExpressi O15405.
Bgeei O15405.
CleanExi HS_TOX3.
Genevestigatori O15405.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 246-576 (ISOFORM 1/2).
    Tissue: Brain.
  4. "TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex."
    Dittmer S., Kovacs Z., Yuan S.H., Siszler G., Kogl M., Summer H., Geerts A., Golz S., Shioda T., Methner A.
    J. Cell Sci. 124:252-260(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, HOMODIMERIZATION, INTERACTION WITH CITED1 AND CREB1, ASSOCIATION WITH CHROMATIN, INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTOX3_HUMAN
AccessioniPrimary (citable) accession number: O15405
Secondary accession number(s): B4DRD0, B5MCW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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