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O15405

- TOX3_HUMAN

UniProt

O15405 - TOX3_HUMAN

Protein

TOX high mobility group box family member 3

Gene

TOX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi255 – 32369HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. estrogen response element binding Source: UniProtKB
    3. phosphoprotein binding Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. negative regulation of neuron apoptotic process Source: UniProtKB
    3. positive regulation of transcription, DNA-templated Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Apoptosis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TOX high mobility group box family member 3
    Alternative name(s):
    CAG trinucleotide repeat-containing gene F9 protein
    Trinucleotide repeat-containing gene 9 protein
    Gene namesi
    Name:TOX3
    Synonyms:CAGF9, TNRC9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:11972. TOX3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162406752.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 576576TOX high mobility group box family member 3PRO_0000286353Add
    BLAST

    Proteomic databases

    MaxQBiO15405.
    PaxDbiO15405.
    PRIDEiO15405.

    PTM databases

    PhosphoSiteiO15405.

    Expressioni

    Tissue specificityi

    Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe.1 Publication

    Inductioni

    Up-regulated by GPR39 in neuronal cells.1 Publication

    Gene expression databases

    ArrayExpressiO15405.
    BgeeiO15405.
    CleanExiHS_TOX3.
    GenevestigatoriO15405.

    Organism-specific databases

    HPAiHPA040376.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with CREB1; the interaction is not depolarization dependent. Interacts with CREBBP (via C-terminus) By similarity. Interacts (via HGM box) with CITED1 (via C-terminus); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with CREB1 (phosphorylated form).By similarity1 Publication

    Protein-protein interaction databases

    BioGridi118139. 1 interaction.
    IntActiO15405. 1 interaction.
    MINTiMINT-2795739.
    STRINGi9606.ENSP00000385705.

    Structurei

    3D structure databases

    ProteinModelPortaliO15405.
    SMRiO15405. Positions 219-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi32 – 354Poly-Asn
    Compositional biasi245 – 2506Poly-Lys
    Compositional biasi431 – 572142Gln-richAdd
    BLAST

    Domaini

    the C-terminus is required for calcium responsiveness but not for transactivation activity.By similarity
    The N-terminus is absolutely necessary for transactivation activity.By similarity

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG284736.
    HOGENOMiHOG000230949.
    HOVERGENiHBG051183.
    OMAiPMNQIVA.
    OrthoDBiEOG7R834J.
    PhylomeDBiO15405.
    TreeFamiTF106481.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O15405-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDVRFYPAAA GDPASLDFAQ CLGYYGYSKF GNNNNYMNMA EANNAFFAAS    50
    EQTFHTPSLG DEEFEIPPIT PPPESDPALG MPDVLLPFQA LSDPLPSQGS 100
    EFTPQFPPQS LDLPSITISR NLVEQDGVLH SSGLHMDQSH TQVSQYRQDP 150
    SLIMRSIVHM TDAARSGVMP PAQLTTINQS QLSAQLGLNL GGASMPHTSP 200
    SPPASKSATP SPSSSINEED ADEANRAIGE KRAAPDSGKK PKTPKKKKKK 250
    DPNEPQKPVS AYALFFRDTQ AAIKGQNPNA TFGEVSKIVA SMWDSLGEEQ 300
    KQVYKRKTEA AKKEYLKALA AYRASLVSKA AAESAEAQTI RSVQQTLAST 350
    NLTSSLLLNT PLSQHGTVSA SPQTLQQSLP RSIAPKPLTM RLPMNQIVTS 400
    VTIAANMPSN IGAPLISSMG TTMVGSAPST QVSPSVQTQQ HQMQLQQQQQ 450
    QQQQQMQQMQ QQQLQQHQMH QQIQQQMQQQ HFQHHMQQHL QQQQQHLQQQ 500
    INQQQLQQQL QQRLQLQQLQ HMQHQSQPSP RQHSPVASQI TSPIPAIGSP 550
    QPASQQHQSQ IQSQTQTQVL SQVSIF 576
    Length:576
    Mass (Da):63,342
    Last modified:May 1, 2007 - v2
    Checksum:i0CE15100A96E1478
    GO
    Isoform 2 (identifier: O15405-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-28: MDVRFYPAAAGDPASLDFAQCLGYYGYS → MKCQPRSGARRIEERLHYLITTYL
         52-52: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:571
    Mass (Da):63,100
    Checksum:i4447F1086050C823
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti128 – 1281V → M.
    Corresponds to variant rs16951186 [ dbSNP | Ensembl ].
    VAR_055952
    Natural varianti572 – 5721Q → P.
    Corresponds to variant rs13332816 [ dbSNP | Ensembl ].
    VAR_055953

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2828MDVRF…YYGYS → MKCQPRSGARRIEERLHYLI TTYL in isoform 2. 1 PublicationVSP_043095Add
    BLAST
    Alternative sequencei52 – 521Missing in isoform 2. 1 PublicationVSP_043096

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK299202 mRNA. Translation: BAG61242.1.
    AC007490 Genomic DNA. No translation available.
    U80736 mRNA. Translation: AAB91435.1.
    CCDSiCCDS54008.1. [O15405-2]
    CCDS54009.1. [O15405-1]
    RefSeqiNP_001073899.2. NM_001080430.2. [O15405-1]
    NP_001139660.1. NM_001146188.1. [O15405-2]
    UniGeneiHs.460789.

    Genome annotation databases

    EnsembliENST00000219746; ENSP00000219746; ENSG00000103460. [O15405-1]
    ENST00000407228; ENSP00000385705; ENSG00000103460. [O15405-2]
    GeneIDi27324.
    KEGGihsa:27324.
    UCSCiuc002egw.2. human. [O15405-1]
    uc010vgt.1. human. [O15405-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK299202 mRNA. Translation: BAG61242.1 .
    AC007490 Genomic DNA. No translation available.
    U80736 mRNA. Translation: AAB91435.1 .
    CCDSi CCDS54008.1. [O15405-2 ]
    CCDS54009.1. [O15405-1 ]
    RefSeqi NP_001073899.2. NM_001080430.2. [O15405-1 ]
    NP_001139660.1. NM_001146188.1. [O15405-2 ]
    UniGenei Hs.460789.

    3D structure databases

    ProteinModelPortali O15405.
    SMRi O15405. Positions 219-335.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118139. 1 interaction.
    IntActi O15405. 1 interaction.
    MINTi MINT-2795739.
    STRINGi 9606.ENSP00000385705.

    PTM databases

    PhosphoSitei O15405.

    Proteomic databases

    MaxQBi O15405.
    PaxDbi O15405.
    PRIDEi O15405.

    Protocols and materials databases

    DNASUi 27324.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000219746 ; ENSP00000219746 ; ENSG00000103460 . [O15405-1 ]
    ENST00000407228 ; ENSP00000385705 ; ENSG00000103460 . [O15405-2 ]
    GeneIDi 27324.
    KEGGi hsa:27324.
    UCSCi uc002egw.2. human. [O15405-1 ]
    uc010vgt.1. human. [O15405-2 ]

    Organism-specific databases

    CTDi 27324.
    GeneCardsi GC16M052471.
    H-InvDB HIX0013031.
    HGNCi HGNC:11972. TOX3.
    HPAi HPA040376.
    MIMi 611416. gene.
    neXtProti NX_O15405.
    PharmGKBi PA162406752.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284736.
    HOGENOMi HOG000230949.
    HOVERGENi HBG051183.
    OMAi PMNQIVA.
    OrthoDBi EOG7R834J.
    PhylomeDBi O15405.
    TreeFami TF106481.

    Miscellaneous databases

    ChiTaRSi TOX3. human.
    GenomeRNAii 27324.
    NextBioi 50340.
    PROi O15405.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15405.
    Bgeei O15405.
    CleanExi HS_TOX3.
    Genevestigatori O15405.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 246-576 (ISOFORM 1/2).
      Tissue: Brain.
    4. "TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex."
      Dittmer S., Kovacs Z., Yuan S.H., Siszler G., Kogl M., Summer H., Geerts A., Golz S., Shioda T., Methner A.
      J. Cell Sci. 124:252-260(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, HOMODIMERIZATION, INTERACTION WITH CITED1 AND CREB1, ASSOCIATION WITH CHROMATIN, INDUCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiTOX3_HUMAN
    AccessioniPrimary (citable) accession number: O15405
    Secondary accession number(s): B4DRD0, B5MCW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3