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Protein

Monocarboxylate transporter 7

Gene

SLC16A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • monocarboxylic acid transport Source: ProtInc
  • plasma membrane lactate transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108932-MONOMER.

Protein family/group databases

TCDBi2.A.1.13.15. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 7
Short name:
MCT 7
Alternative name(s):
Monocarboxylate transporter 6
Short name:
MCT 6
Solute carrier family 16 member 6
Gene namesi
Name:SLC16A6
Synonyms:MCT6, MCT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10927. SLC16A6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 62ExtracellularSequence analysisAdd BLAST20
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Topological domaini84 – 91CytoplasmicSequence analysis8
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 118ExtracellularSequence analysis6
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 149CytoplasmicSequence analysis10
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 184ExtracellularSequence analysisAdd BLAST14
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 299CytoplasmicSequence analysisAdd BLAST94
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21
Topological domaini321 – 330ExtracellularSequence analysis10
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Topological domaini352 – 358CytoplasmicSequence analysis7
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Topological domaini380 – 381ExtracellularSequence analysis2
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Topological domaini403 – 423CytoplasmicSequence analysisAdd BLAST21
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 452ExtracellularSequence analysis8
Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
Topological domaini474 – 523CytoplasmicSequence analysisAdd BLAST50

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9120.
OpenTargetsiENSG00000108932.
PharmGKBiPA35818.

Chemistry databases

DrugBankiDB00119. Pyruvic acid.

Polymorphism and mutation databases

BioMutaiSLC16A6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114001 – 523Monocarboxylate transporter 7Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234PhosphoserineBy similarity1
Modified residuei237PhosphoserineCombined sources1
Modified residuei240PhosphoserineCombined sources1
Modified residuei247PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15403.
PaxDbiO15403.
PeptideAtlasiO15403.
PRIDEiO15403.

PTM databases

iPTMnetiO15403.
PhosphoSitePlusiO15403.

Expressioni

Gene expression databases

BgeeiENSG00000108932.
CleanExiHS_SLC16A6.
ExpressionAtlasiO15403. baseline and differential.
GenevisibleiO15403. HS.

Organism-specific databases

HPAiHPA054459.

Interactioni

Protein-protein interaction databases

BioGridi114568. 6 interactors.
IntActiO15403. 5 interactors.
STRINGi9606.ENSP00000319991.

Structurei

3D structure databases

ProteinModelPortaliO15403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000049166.
HOVERGENiHBG006386.
InParanoidiO15403.
KOiK08183.
OMAiAFAPAIM.
OrthoDBiEOG091G04FE.
PhylomeDBiO15403.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR030766. MCT7.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF20. PTHR11360:SF20. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQNKLKLCS KANVYTEVPD GGWGWAVAVS FFFVEVFTYG IIKTFGVFFN
60 70 80 90 100
DLMDSFNESN SRISWIISIC VFVLTFSAPL ATVLSNRFGH RLVVMLGGLL
110 120 130 140 150
VSTGMVAASF SQEVSHMYVA IGIISGLGYC FSFLPTVTIL SQYFGKRRSI
160 170 180 190 200
VTAVASTGEC FAVFAFAPAI MALKERIGWR YSLLFVGLLQ LNIVIFGALL
210 220 230 240 250
RPIFIRGPAS PKIVIQENRK EAQYMLENEK TRTSIDSIDS GVELTTSPKN
260 270 280 290 300
VPTHTNLELE PKADMQQVLV KTSPRPSEKK APLLDFSILK EKSFICYALF
310 320 330 340 350
GLFATLGFFA PSLYIIPLGI SLGIDQDRAA FLLSTMAIAE VFGRIGAGFV
360 370 380 390 400
LNREPIRKIY IELICVILLT VSLFAFTFAT EFWGLMSCSI FFGFMVGTIG
410 420 430 440 450
GTHIPLLAED DVVGIEKMSS AAGVYIFIQS IAGLAGPPLA GLLVDQSKIY
460 470 480 490 500
SRAFYSCAAG MALAAVCLAL VRPCKMGLCQ HHHSGETKVV SHRGKTLQDI
510 520
PEDFLEMDLA KNEHRVHVQM EPV
Length:523
Mass (Da):57,393
Last modified:September 23, 2008 - v2
Checksum:i994FB5DCB9404340
GO

Sequence cautioni

The sequence AAC52014 differs from that shown. Reason: Frameshift at positions 401 and 416.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti481H → R in AAC52014 (PubMed:9425115).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053656121I → T.Corresponds to variant rs35397826dbSNPEnsembl.1
Natural variantiVAR_053657204F → I.1 PublicationCorresponds to variant rs7222013dbSNPEnsembl.1
Natural variantiVAR_053658217E → D.Corresponds to variant rs3744307dbSNPEnsembl.1
Natural variantiVAR_053659221E → V.Corresponds to variant rs4410141dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79745 mRNA. Translation: AAC52014.1. Frameshift.
CH471099 Genomic DNA. Translation: EAW89052.1.
BC064832 mRNA. Translation: AAH64832.1.
CCDSiCCDS11675.1.
RefSeqiNP_001167637.1. NM_001174166.1.
NP_004685.2. NM_004694.4.
XP_011523763.1. XM_011525461.2.
XP_016880780.1. XM_017025291.1.
XP_016880781.1. XM_017025292.1.
UniGeneiHs.42645.

Genome annotation databases

EnsembliENST00000327268; ENSP00000319991; ENSG00000108932.
ENST00000580666; ENSP00000462985; ENSG00000108932.
GeneIDi9120.
KEGGihsa:9120.
UCSCiuc002jgz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79745 mRNA. Translation: AAC52014.1. Frameshift.
CH471099 Genomic DNA. Translation: EAW89052.1.
BC064832 mRNA. Translation: AAH64832.1.
CCDSiCCDS11675.1.
RefSeqiNP_001167637.1. NM_001174166.1.
NP_004685.2. NM_004694.4.
XP_011523763.1. XM_011525461.2.
XP_016880780.1. XM_017025291.1.
XP_016880781.1. XM_017025292.1.
UniGeneiHs.42645.

3D structure databases

ProteinModelPortaliO15403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114568. 6 interactors.
IntActiO15403. 5 interactors.
STRINGi9606.ENSP00000319991.

Chemistry databases

DrugBankiDB00119. Pyruvic acid.

Protein family/group databases

TCDBi2.A.1.13.15. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiO15403.
PhosphoSitePlusiO15403.

Polymorphism and mutation databases

BioMutaiSLC16A6.

Proteomic databases

MaxQBiO15403.
PaxDbiO15403.
PeptideAtlasiO15403.
PRIDEiO15403.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327268; ENSP00000319991; ENSG00000108932.
ENST00000580666; ENSP00000462985; ENSG00000108932.
GeneIDi9120.
KEGGihsa:9120.
UCSCiuc002jgz.3. human.

Organism-specific databases

CTDi9120.
DisGeNETi9120.
GeneCardsiSLC16A6.
H-InvDBHIX0039198.
HGNCiHGNC:10927. SLC16A6.
HPAiHPA054459.
MIMi603880. gene.
neXtProtiNX_O15403.
OpenTargetsiENSG00000108932.
PharmGKBiPA35818.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000049166.
HOVERGENiHBG006386.
InParanoidiO15403.
KOiK08183.
OMAiAFAPAIM.
OrthoDBiEOG091G04FE.
PhylomeDBiO15403.
TreeFamiTF313792.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108932-MONOMER.

Miscellaneous databases

GenomeRNAii9120.
PROiO15403.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108932.
CleanExiHS_SLC16A6.
ExpressionAtlasiO15403. baseline and differential.
GenevisibleiO15403. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR030766. MCT7.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF20. PTHR11360:SF20. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOT7_HUMAN
AccessioniPrimary (citable) accession number: O15403
Secondary accession number(s): Q6P1X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.