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Protein

Monocarboxylate transporter 7

Gene

SLC16A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • monocarboxylic acid transport Source: ProtInc
  • plasma membrane lactate transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Protein family/group databases

TCDBi2.A.1.13.15. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 7
Short name:
MCT 7
Alternative name(s):
Monocarboxylate transporter 6
Short name:
MCT 6
Solute carrier family 16 member 6
Gene namesi
Name:SLC16A6
Synonyms:MCT6, MCT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10927. SLC16A6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121CytoplasmicSequence analysisAdd
BLAST
Transmembranei22 – 4221HelicalSequence analysisAdd
BLAST
Topological domaini43 – 6220ExtracellularSequence analysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence analysisAdd
BLAST
Topological domaini84 – 918CytoplasmicSequence analysis
Transmembranei92 – 11221HelicalSequence analysisAdd
BLAST
Topological domaini113 – 1186ExtracellularSequence analysis
Transmembranei119 – 13921HelicalSequence analysisAdd
BLAST
Topological domaini140 – 14910CytoplasmicSequence analysis
Transmembranei150 – 17021HelicalSequence analysisAdd
BLAST
Topological domaini171 – 18414ExtracellularSequence analysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence analysisAdd
BLAST
Topological domaini206 – 29994CytoplasmicSequence analysisAdd
BLAST
Transmembranei300 – 32021HelicalSequence analysisAdd
BLAST
Topological domaini321 – 33010ExtracellularSequence analysis
Transmembranei331 – 35121HelicalSequence analysisAdd
BLAST
Topological domaini352 – 3587CytoplasmicSequence analysis
Transmembranei359 – 37921HelicalSequence analysisAdd
BLAST
Topological domaini380 – 3812ExtracellularSequence analysis
Transmembranei382 – 40221HelicalSequence analysisAdd
BLAST
Topological domaini403 – 42321CytoplasmicSequence analysisAdd
BLAST
Transmembranei424 – 44421HelicalSequence analysisAdd
BLAST
Topological domaini445 – 4528ExtracellularSequence analysis
Transmembranei453 – 47321HelicalSequence analysisAdd
BLAST
Topological domaini474 – 52350CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35818.

Chemistry

DrugBankiDB00119. Pyruvic acid.

Polymorphism and mutation databases

BioMutaiSLC16A6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Monocarboxylate transporter 7PRO_0000211400Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei234 – 2341PhosphoserineBy similarity
Modified residuei237 – 2371PhosphoserineCombined sources
Modified residuei240 – 2401PhosphoserineCombined sources
Modified residuei247 – 2471PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15403.
PaxDbiO15403.
PRIDEiO15403.

PTM databases

iPTMnetiO15403.
PhosphoSiteiO15403.

Expressioni

Gene expression databases

BgeeiO15403.
CleanExiHS_SLC16A6.
ExpressionAtlasiO15403. baseline and differential.
GenevisibleiO15403. HS.

Organism-specific databases

HPAiHPA054459.

Interactioni

Protein-protein interaction databases

BioGridi114568. 6 interactions.
IntActiO15403. 5 interactions.
STRINGi9606.ENSP00000319991.

Structurei

3D structure databases

ProteinModelPortaliO15403.
SMRiO15403. Positions 157-186, 423-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000049166.
HOVERGENiHBG006386.
InParanoidiO15403.
KOiK08183.
OMAiAFAPAIM.
PhylomeDBiO15403.
TreeFamiTF313792.

Family and domain databases

InterProiIPR030766. MCT7.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF20. PTHR11360:SF20. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQNKLKLCS KANVYTEVPD GGWGWAVAVS FFFVEVFTYG IIKTFGVFFN
60 70 80 90 100
DLMDSFNESN SRISWIISIC VFVLTFSAPL ATVLSNRFGH RLVVMLGGLL
110 120 130 140 150
VSTGMVAASF SQEVSHMYVA IGIISGLGYC FSFLPTVTIL SQYFGKRRSI
160 170 180 190 200
VTAVASTGEC FAVFAFAPAI MALKERIGWR YSLLFVGLLQ LNIVIFGALL
210 220 230 240 250
RPIFIRGPAS PKIVIQENRK EAQYMLENEK TRTSIDSIDS GVELTTSPKN
260 270 280 290 300
VPTHTNLELE PKADMQQVLV KTSPRPSEKK APLLDFSILK EKSFICYALF
310 320 330 340 350
GLFATLGFFA PSLYIIPLGI SLGIDQDRAA FLLSTMAIAE VFGRIGAGFV
360 370 380 390 400
LNREPIRKIY IELICVILLT VSLFAFTFAT EFWGLMSCSI FFGFMVGTIG
410 420 430 440 450
GTHIPLLAED DVVGIEKMSS AAGVYIFIQS IAGLAGPPLA GLLVDQSKIY
460 470 480 490 500
SRAFYSCAAG MALAAVCLAL VRPCKMGLCQ HHHSGETKVV SHRGKTLQDI
510 520
PEDFLEMDLA KNEHRVHVQM EPV
Length:523
Mass (Da):57,393
Last modified:September 23, 2008 - v2
Checksum:i994FB5DCB9404340
GO

Sequence cautioni

The sequence AAC52014.1 differs from that shown. Reason: Frameshift at positions 401 and 416. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti481 – 4811H → R in AAC52014 (PubMed:9425115).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211I → T.
Corresponds to variant rs35397826 [ dbSNP | Ensembl ].
VAR_053656
Natural varianti204 – 2041F → I.1 Publication
Corresponds to variant rs7222013 [ dbSNP | Ensembl ].
VAR_053657
Natural varianti217 – 2171E → D.
Corresponds to variant rs3744307 [ dbSNP | Ensembl ].
VAR_053658
Natural varianti221 – 2211E → V.
Corresponds to variant rs4410141 [ dbSNP | Ensembl ].
VAR_053659

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79745 mRNA. Translation: AAC52014.1. Frameshift.
CH471099 Genomic DNA. Translation: EAW89052.1.
BC064832 mRNA. Translation: AAH64832.1.
CCDSiCCDS11675.1.
RefSeqiNP_001167637.1. NM_001174166.1.
NP_004685.2. NM_004694.4.
XP_011523763.1. XM_011525461.1.
UniGeneiHs.42645.

Genome annotation databases

EnsembliENST00000327268; ENSP00000319991; ENSG00000108932.
ENST00000580666; ENSP00000462985; ENSG00000108932.
GeneIDi9120.
KEGGihsa:9120.
UCSCiuc002jgz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79745 mRNA. Translation: AAC52014.1. Frameshift.
CH471099 Genomic DNA. Translation: EAW89052.1.
BC064832 mRNA. Translation: AAH64832.1.
CCDSiCCDS11675.1.
RefSeqiNP_001167637.1. NM_001174166.1.
NP_004685.2. NM_004694.4.
XP_011523763.1. XM_011525461.1.
UniGeneiHs.42645.

3D structure databases

ProteinModelPortaliO15403.
SMRiO15403. Positions 157-186, 423-448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114568. 6 interactions.
IntActiO15403. 5 interactions.
STRINGi9606.ENSP00000319991.

Chemistry

DrugBankiDB00119. Pyruvic acid.

Protein family/group databases

TCDBi2.A.1.13.15. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiO15403.
PhosphoSiteiO15403.

Polymorphism and mutation databases

BioMutaiSLC16A6.

Proteomic databases

MaxQBiO15403.
PaxDbiO15403.
PRIDEiO15403.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327268; ENSP00000319991; ENSG00000108932.
ENST00000580666; ENSP00000462985; ENSG00000108932.
GeneIDi9120.
KEGGihsa:9120.
UCSCiuc002jgz.3. human.

Organism-specific databases

CTDi9120.
GeneCardsiSLC16A6.
H-InvDBHIX0039198.
HGNCiHGNC:10927. SLC16A6.
HPAiHPA054459.
MIMi603880. gene.
neXtProtiNX_O15403.
PharmGKBiPA35818.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000049166.
HOVERGENiHBG006386.
InParanoidiO15403.
KOiK08183.
OMAiAFAPAIM.
PhylomeDBiO15403.
TreeFamiTF313792.

Miscellaneous databases

GenomeRNAii9120.
NextBioi34179.
PROiO15403.
SOURCEiSearch...

Gene expression databases

BgeeiO15403.
CleanExiHS_SLC16A6.
ExpressionAtlasiO15403. baseline and differential.
GenevisibleiO15403. HS.

Family and domain databases

InterProiIPR030766. MCT7.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF20. PTHR11360:SF20. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past."
    Price N.T., Jackson V.N., Halestrap A.P.
    Biochem. J. 329:321-328(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-204.
    Tissue: Blood.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237 AND SER-240, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237; SER-240 AND SER-247, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiMOT7_HUMAN
AccessioniPrimary (citable) accession number: O15403
Secondary accession number(s): Q6P1X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 23, 2008
Last modified: April 13, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.