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Protein

Syntaxin-7

Gene

STX7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.

GO - Molecular functioni

  • chloride channel inhibitor activity Source: UniProtKB
  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: MGI
  • syntaxin binding Source: UniProtKB

GO - Biological processi

  • intracellular protein transport Source: GO_Central
  • organelle assembly Source: UniProtKB
  • organelle localization Source: UniProtKB
  • positive regulation of receptor localization to synapse Source: UniProtKB
  • positive regulation of T cell mediated cytotoxicity Source: UniProtKB
  • regulation of protein localization to plasma membrane Source: UniProtKB
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000079950-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-7
Gene namesi
Name:STX7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:11442. STX7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 238CytoplasmicSequence analysisAdd BLAST237
Transmembranei239 – 259Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini260 – 261VesicularSequence analysis2

GO - Cellular componenti

  • azurophil granule Source: UniProtKB
  • early endosome Source: UniProtKB
  • early endosome membrane Source: UniProtKB-SubCell
  • endocytic vesicle Source: UniProtKB
  • endosome Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • immunological synapse Source: UniProtKB
  • integral component of membrane Source: GO_Central
  • intracellular membrane-bounded organelle Source: HPA
  • late endosome Source: UniProtKB
  • lysosomal membrane Source: UniProtKB
  • lysosome Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • recycling endosome Source: UniProtKB
  • SNARE complex Source: GO_Central
  • tertiary granule Source: UniProtKB
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8417.
OpenTargetsiENSG00000079950.
PharmGKBiPA36239.

Polymorphism and mutation databases

BioMutaiSTX7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002102132 – 261Syntaxin-7Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei4PhosphothreonineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei79PhosphothreonineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei126PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO15400.
MaxQBiO15400.
PaxDbiO15400.
PeptideAtlasiO15400.
PRIDEiO15400.
TopDownProteomicsiO15400-1. [O15400-1]

2D gel databases

OGPiO15400.

PTM databases

iPTMnetiO15400.
PhosphoSitePlusiO15400.
SwissPalmiO15400.

Miscellaneous databases

PMAP-CutDBO15400.

Expressioni

Tissue specificityi

Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low expression is found in pancreas, lung and liver.

Gene expression databases

BgeeiENSG00000079950.
CleanExiHS_STX7.
GenevisibleiO15400. HS.

Organism-specific databases

HPAiCAB062564.
HPA001467.

Interactioni

Subunit structurei

Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes (By similarity). Interacts with VPS11, VPS16 and VPS18. Interacts with VPS33A.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
STX4Q128466EBI-3221827,EBI-744942
VPS11Q9H2702EBI-3221827,EBI-373380
VPS18Q9P2532EBI-3221827,EBI-1053363

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: MGI
  • syntaxin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114003. 94 interactors.
DIPiDIP-57384N.
IntActiO15400. 22 interactors.
MINTiMINT-5002218.
STRINGi9606.ENSP00000356918.

Structurei

3D structure databases

ProteinModelPortaliO15400.
SMRiO15400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 227t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili47 – 69Sequence analysisAdd BLAST23

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0811. Eukaryota.
COG5325. LUCA.
GeneTreeiENSGT00450000040239.
HOGENOMiHOG000188453.
HOVERGENiHBG053083.
InParanoidiO15400.
KOiK08488.
OMAiVHIQQAN.
OrthoDBiEOG091G0HKZ.
PhylomeDBiO15400.
TreeFamiTF315607.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15400-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYTPGVGGD PAQLAQRISS NIQKITQCSV EIQRTLNQLG TPQDSPELRQ
60 70 80 90 100
QLQQKQQYTN QLAKETDKYI KEFGSLPTTP SEQRQRKIQK DRLVAEFTTS
110 120 130 140 150
LTNFQKVQRQ AAEREKEFVA RVRASSRVSG SFPEDSSKER NLVSWESQTQ
160 170 180 190 200
PQVQVQDEEI TEDDLRLIHE RESSIRQLEA DIMDINEIFK DLGMMIHEQG
210 220 230 240 250
DVIDSIEANV ENAEVHVQQA NQQLSRAADY QRKSRKTLCI IILILVIGVA
260
IISLIIWGLN H
Length:261
Mass (Da):29,816
Last modified:January 23, 2007 - v4
Checksum:i42AC173F0233ACDA
GO
Isoform 2 (identifier: O15400-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-261: RKSRKTLCIIILILVIGVAIISLIIWGLNH → KKDSCMLM

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):27,400
Checksum:i6F35F3042EECF335
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12A → T in AAC51851 (PubMed:9358037).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012938232 – 261RKSRK…WGLNH → KKDSCMLM in isoform 2. CuratedAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77942 mRNA. Translation: AAC51851.1.
AL357034 Genomic DNA. Translation: CAI15716.1.
AL357034 Genomic DNA. Translation: CAI15717.1.
AL589691 Genomic DNA. Translation: CAI16816.1.
AL589691 Genomic DNA. Translation: CAI16817.1.
CH471051 Genomic DNA. Translation: EAW48029.1.
CH471051 Genomic DNA. Translation: EAW48030.1.
BC011975 mRNA. Translation: AAH11975.1.
CCDSiCCDS5153.1. [O15400-1]
RefSeqiNP_001313507.1. NM_001326578.1. [O15400-1]
NP_001313508.1. NM_001326579.1. [O15400-1]
NP_001313509.1. NM_001326580.1. [O15400-2]
NP_003560.2. NM_003569.2. [O15400-1]
XP_011534480.1. XM_011536178.1. [O15400-2]
UniGeneiHs.593148.
Hs.605992.

Genome annotation databases

EnsembliENST00000367937; ENSP00000356914; ENSG00000079950. [O15400-2]
ENST00000367941; ENSP00000356918; ENSG00000079950. [O15400-1]
GeneIDi8417.
KEGGihsa:8417.
UCSCiuc003qdg.3. human. [O15400-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77942 mRNA. Translation: AAC51851.1.
AL357034 Genomic DNA. Translation: CAI15716.1.
AL357034 Genomic DNA. Translation: CAI15717.1.
AL589691 Genomic DNA. Translation: CAI16816.1.
AL589691 Genomic DNA. Translation: CAI16817.1.
CH471051 Genomic DNA. Translation: EAW48029.1.
CH471051 Genomic DNA. Translation: EAW48030.1.
BC011975 mRNA. Translation: AAH11975.1.
CCDSiCCDS5153.1. [O15400-1]
RefSeqiNP_001313507.1. NM_001326578.1. [O15400-1]
NP_001313508.1. NM_001326579.1. [O15400-1]
NP_001313509.1. NM_001326580.1. [O15400-2]
NP_003560.2. NM_003569.2. [O15400-1]
XP_011534480.1. XM_011536178.1. [O15400-2]
UniGeneiHs.593148.
Hs.605992.

3D structure databases

ProteinModelPortaliO15400.
SMRiO15400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114003. 94 interactors.
DIPiDIP-57384N.
IntActiO15400. 22 interactors.
MINTiMINT-5002218.
STRINGi9606.ENSP00000356918.

PTM databases

iPTMnetiO15400.
PhosphoSitePlusiO15400.
SwissPalmiO15400.

Polymorphism and mutation databases

BioMutaiSTX7.

2D gel databases

OGPiO15400.

Proteomic databases

EPDiO15400.
MaxQBiO15400.
PaxDbiO15400.
PeptideAtlasiO15400.
PRIDEiO15400.
TopDownProteomicsiO15400-1. [O15400-1]

Protocols and materials databases

DNASUi8417.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367937; ENSP00000356914; ENSG00000079950. [O15400-2]
ENST00000367941; ENSP00000356918; ENSG00000079950. [O15400-1]
GeneIDi8417.
KEGGihsa:8417.
UCSCiuc003qdg.3. human. [O15400-1]

Organism-specific databases

CTDi8417.
DisGeNETi8417.
GeneCardsiSTX7.
HGNCiHGNC:11442. STX7.
HPAiCAB062564.
HPA001467.
MIMi603217. gene.
neXtProtiNX_O15400.
OpenTargetsiENSG00000079950.
PharmGKBiPA36239.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0811. Eukaryota.
COG5325. LUCA.
GeneTreeiENSGT00450000040239.
HOGENOMiHOG000188453.
HOVERGENiHBG053083.
InParanoidiO15400.
KOiK08488.
OMAiVHIQQAN.
OrthoDBiEOG091G0HKZ.
PhylomeDBiO15400.
TreeFamiTF315607.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000079950-MONOMER.

Miscellaneous databases

ChiTaRSiSTX7. human.
GeneWikiiSTX7.
GenomeRNAii8417.
PMAP-CutDBO15400.
PROiO15400.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079950.
CleanExiHS_STX7.
GenevisibleiO15400. HS.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX7_HUMAN
AccessioniPrimary (citable) accession number: O15400
Secondary accession number(s): E1P579, Q5SZW2, Q96ES9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 155 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.