SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O15399

- NMDE4_HUMAN

UniProt

O15399 - NMDE4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glutamate receptor ionotropic, NMDA 2D
Gene
GRIN2D, GluN2D, NMDAR2D
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei642 – 6421Functional determinant of NMDA receptors By similarity

GO - Molecular functioni

  1. N-methyl-D-aspartate selective glutamate receptor activity Source: RefGenome
  2. extracellular-glutamate-gated ion channel activity Source: RefGenome
  3. protein binding Source: IntAct

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. ion transmembrane transport Source: RefGenome
  3. ionotropic glutamate receptor signaling pathway Source: RefGenome
  4. regulation of sensory perception of pain Source: Ensembl
  5. signal transduction Source: ProtInc
  6. startle response Source: Ensembl
  7. synaptic transmission Source: Reactome
  8. synaptic transmission, glutamatergic Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Magnesium

Enzyme and pathway databases

ReactomeiREACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.
REACT_20594. Unblocking of NMDA receptor, glutamate binding and activation.
REACT_20642. CREB phosphorylation through the activation of CaMKII.
SignaLinkiO15399.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 2D
Short name:
GluN2D
Alternative name(s):
EB11
Glutamate [NMDA] receptor subunit epsilon-4
N-methyl D-aspartate receptor subtype 2D
Short name:
NMDAR2D
Short name:
NR2D
Gene namesi
Name:GRIN2D
Synonyms:GluN2D, NMDAR2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:4588. GRIN2D.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 583556Extracellular Reviewed prediction
Add
BLAST
Transmembranei584 – 60421Helical; Reviewed prediction
Add
BLAST
Topological domaini605 – 65652Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei657 – 67721Helical; Reviewed prediction
Add
BLAST
Topological domaini678 – 844167Extracellular Reviewed prediction
Add
BLAST
Transmembranei845 – 86521Helical; Reviewed prediction
Add
BLAST
Topological domaini866 – 1336471Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. N-methyl-D-aspartate selective glutamate receptor complex Source: RefGenome
  2. cell junction Source: UniProtKB-KW
  3. dendrite Source: RefGenome
  4. plasma membrane Source: Reactome
  5. postsynaptic membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 13361309Glutamate receptor ionotropic, NMDA 2D
PRO_0000011583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi352 – 3521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi366 – 3661N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi455 ↔ 483 By similarity
Disulfide bondi462 ↔ 484 By similarity
Glycosylationi467 – 4671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi569 – 5691N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi773 ↔ 828 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO15399.
PRIDEiO15399.

PTM databases

PhosphoSiteiO15399.

Expressioni

Gene expression databases

BgeeiO15399.
CleanExiHS_GRIN2D.
GenevestigatoriO15399.

Organism-specific databases

HPAiHPA038269.

Interactioni

Subunit structurei

Interacts with PDZ domains of INADL and DLG4 By similarity. Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B).

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg3Q629362EBI-1754030,EBI-349596From a different organism.

Protein-protein interaction databases

BioGridi109163. 4 interactions.
IntActiO15399. 4 interactions.
MINTiMINT-130143.
STRINGi9606.ENSP00000263269.

Structurei

3D structure databases

ProteinModelPortaliO15399.
SMRiO15399. Positions 99-288, 429-567, 689-829.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1334 – 13363PDZ-binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi281 – 2866Poly-Gly
Compositional biasi908 – 9169Poly-Pro
Compositional biasi1035 – 10406Poly-Ala
Compositional biasi1209 – 12135Poly-Pro
Compositional biasi1244 – 12474Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG282132.
HOGENOMiHOG000113803.
HOVERGENiHBG052637.
InParanoidiO15399.
KOiK05212.
OMAiWDYLPPR.
OrthoDBiEOG72ZCD1.
PhylomeDBiO15399.
TreeFamiTF314731.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15399-1 [UniParc]FASTAAdd to Basket

« Hide

MRGAGGPRGP RGPAKMLLLL ALACASPFPE EAPGPGGAGG PGGGLGGARP     50
LNVALVFSGP AYAAEAARLG PAVAAAVRSP GLDVRPVALV LNGSDPRSLV 100
LQLCDLLSGL RVHGVVFEDD SRAPAVAPIL DFLSAQTSLP IVAVHGGAAL 150
VLTPKEKGST FLQLGSSTEQ QLQVIFEVLE EYDWTSFVAV TTRAPGHRAF 200
LSYIEVLTDG SLVGWEHRGA LTLDPGAGEA VLSAQLRSVS AQIRLLFCAR 250
EEAEPVFRAA EEAGLTGSGY VWFMVGPQLA GGGGSGAPGE PPLLPGGAPL 300
PAGLFAVRSA GWRDDLARRV AAGVAVVARG AQALLRDYGF LPELGHDCRA 350
QNRTHRGESL HRYFMNITWD NRDYSFNEDG FLVNPSLVVI SLTRDRTWEV 400
VGSWEQQTLR LKYPLWSRYG RFLQPVDDTQ HLTVATLEER PFVIVEPADP 450
ISGTCIRDSV PCRSQLNRTH SPPPDAPRPE KRCCKGFCID ILKRLAHTIG 500
FSYDLYLVTN GKHGKKIDGV WNGMIGEVFY QRADMAIGSL TINEERSEIV 550
DFSVPFVETG ISVMVARSNG TVSPSAFLEP YSPAVWVMMF VMCLTVVAVT 600
VFIFEYLSPV GYNRSLATGK RPGGSTFTIG KSIWLLWALV FNNSVPVENP 650
RGTTSKIMVL VWAFFAVIFL ASYTANLAAF MIQEEYVDTV SGLSDRKFQR 700
PQEQYPPLKF GTVPNGSTEK NIRSNYPDMH SYMVRYNQPR VEEALTQLKA 750
GKLDAFIYDA AVLNYMARKD EGCKLVTIGS GKVFATTGYG IALHKGSRWK 800
RPIDLALLQF LGDDEIEMLE RLWLSGICHN DKIEVMSSKL DIDNMAGVFY 850
MLLVAMGLSL LVFAWEHLVY WRLRHCLGPT HRMDFLLAFS RGMYSCCSAE 900
AAPPPAKPPP PPQPLPSPAY PAPRPAPGPA PFVPRERASV DRWRRTKGAG 950
PPGGAGLADG FHRYYGPIEP QGLGLGLGEA RAAPRGAAGR PLSPPAAQPP 1000
QKPPPSYFAI VRDKEPAEPP AGAFPGFPSP PAPPAAAATA VGPPLCRLAF 1050
EDESPPAPAR WPRSDPESQP LLGPGAGGAG GTGGAGGGAP AAPPPCRAAP 1100
PPCPYLDLEP SPSDSEDSES LGGASLGGLE PWWFADFPYP YAERLGPPPG 1150
RYWSVDKLGG WRAGSWDYLP PRSGPAAWHC RHCASLELLP PPRHLSCSHD 1200
GLDGGWWAPP PPPWAAGPLP RRRARCGCPR SHPHRPRASH RTPAAAAPHH 1250
HRHRRAAGGW DLPPPAPTSR SLEDLSSCPR AAPARRLTGP SRHARRCPHA 1300
AHWGPPLPTA SHRRHRGGDL GTRRGSAHFS SLESEV 1336
Length:1,336
Mass (Da):143,752
Last modified:May 5, 2009 - v2
Checksum:i0DB7559056AE4593
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401P → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_035698
Natural varianti286 – 2861G → R in a breast cancer sample; somatic mutation. 1 Publication
VAR_035699
Natural varianti527 – 5271E → G in a breast cancer sample; somatic mutation. 1 Publication
VAR_035700

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti924 – 9241R → G in AAC15910. 1 Publication
Sequence conflicti1005 – 10051P → A in AAC15910. 1 Publication
Sequence conflicti1097 – 10971R → C in AAC15910. 1 Publication
Sequence conflicti1130 – 11301E → D in AAC15910. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77783 mRNA. Translation: AAC15910.1.
AC008403 Genomic DNA. No translation available.
AC011527 Genomic DNA. No translation available.
CCDSiCCDS12719.1.
RefSeqiNP_000827.2. NM_000836.2.
UniGeneiHs.445015.

Genome annotation databases

EnsembliENST00000263269; ENSP00000263269; ENSG00000105464.
GeneIDi2906.
KEGGihsa:2906.
UCSCiuc002pjc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77783 mRNA. Translation: AAC15910.1 .
AC008403 Genomic DNA. No translation available.
AC011527 Genomic DNA. No translation available.
CCDSi CCDS12719.1.
RefSeqi NP_000827.2. NM_000836.2.
UniGenei Hs.445015.

3D structure databases

ProteinModelPortali O15399.
SMRi O15399. Positions 99-288, 429-567, 689-829.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109163. 4 interactions.
IntActi O15399. 4 interactions.
MINTi MINT-130143.
STRINGi 9606.ENSP00000263269.

Chemistry

BindingDBi O15399.
ChEMBLi CHEMBL3038505.
DrugBanki DB00142. L-Glutamic Acid.
DB00836. Loperamide.
DB01173. Orphenadrine.
GuidetoPHARMACOLOGYi 459.

PTM databases

PhosphoSitei O15399.

Proteomic databases

PaxDbi O15399.
PRIDEi O15399.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263269 ; ENSP00000263269 ; ENSG00000105464 .
GeneIDi 2906.
KEGGi hsa:2906.
UCSCi uc002pjc.4. human.

Organism-specific databases

CTDi 2906.
GeneCardsi GC19P048898.
H-InvDB HIX0040164.
HGNCi HGNC:4588. GRIN2D.
HPAi HPA038269.
MIMi 602717. gene.
neXtProti NX_O15399.
PharmGKBi PA28982.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282132.
HOGENOMi HOG000113803.
HOVERGENi HBG052637.
InParanoidi O15399.
KOi K05212.
OMAi WDYLPPR.
OrthoDBi EOG72ZCD1.
PhylomeDBi O15399.
TreeFami TF314731.

Enzyme and pathway databases

Reactomei REACT_20546. Ras activation uopn Ca2+ infux through NMDA receptor.
REACT_20594. Unblocking of NMDA receptor, glutamate binding and activation.
REACT_20642. CREB phosphorylation through the activation of CaMKII.
SignaLinki O15399.

Miscellaneous databases

GeneWikii GRIN2D.
GenomeRNAii 2906.
NextBioi 11507.
PROi O15399.
SOURCEi Search...

Gene expression databases

Bgeei O15399.
CleanExi HS_GRIN2D.
Genevestigatori O15399.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors."
    Hess S.D., Daggett L.P., Deal C., Lu C.-C., Johnson E.C., Velicelebi G.
    J. Neurochem. 70:1269-1279(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-140; ARG-286 AND GLY-527.

Entry informationi

Entry nameiNMDE4_HUMAN
AccessioniPrimary (citable) accession number: O15399
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 5, 2009
Last modified: September 3, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi