##gff-version 3
O15397	UniProtKB	Chain	1	1037	.	.	.	ID=PRO_0000120752;Note=Importin-8	
O15397	UniProtKB	Domain	22	102	.	.	.	Note=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00115	
O15397	UniProtKB	Region	886	934	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O15397	UniProtKB	Modified residue	902	902	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692	
O15397	UniProtKB	Modified residue	903	903	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692	
O15397	UniProtKB	Alternative sequence	1	213	.	.	.	ID=VSP_042574;Note=In isoform 2. MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIVSDHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEAIFPFNIHENDRQQIRDNIVEGIIRSPDLVRVQLTMCLRAIIKHDFPGHWPGVVDKIDYYLQSQSSASWLGSLLCLYQLVKTYEYKKAEEREPLIIAMQIFLPRIQQQIVQLLPDSSYYSVLLQKQILKIFYALVQ->MESLTLKG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
O15397	UniProtKB	Natural variant	6	6	.	.	.	ID=VAR_055118;Note=I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9214382;Dbxref=dbSNP:rs1054423,PMID:9214382	
O15397	UniProtKB	Natural variant	28	1037	.	.	.	ID=VAR_086233;Note=In VISS%3B undetectable protein levels in either patient's fibroblasts or patient's Epstein-Barr virus-immortalized B cell lines. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34010604;Dbxref=PMID:34010604	
O15397	UniProtKB	Natural variant	88	88	.	.	.	ID=VAR_086234;Note=In VISS%3B very low protein expression levels%2C if any%2C in either patient's fibroblasts or patient's Epstein-Barr virus-immortalized B cell lines. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34010604;Dbxref=dbSNP:rs1234764565,PMID:34010604	
O15397	UniProtKB	Natural variant	234	1037	.	.	.	ID=VAR_086235;Note=In VISS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33875846;Dbxref=PMID:33875846	
O15397	UniProtKB	Natural variant	259	1037	.	.	.	ID=VAR_086236;Note=In VISS. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:33875846,ECO:0000269|PubMed:34010605;Dbxref=PMID:33875846,PMID:34010605	
O15397	UniProtKB	Natural variant	317	317	.	.	.	ID=VAR_086237;Note=In VISS%3B uncertain significance. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33875846;Dbxref=PMID:33875846	
O15397	UniProtKB	Natural variant	474	1037	.	.	.	ID=VAR_086238;Note=In VISS%3B undetectable protein levels in patient's fibroblasts%2C although mRNA levels seem unaffected. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34010605;Dbxref=PMID:34010605	
O15397	UniProtKB	Natural variant	640	640	.	.	.	ID=VAR_055119;Note=I->V;Dbxref=dbSNP:rs34119940	
O15397	UniProtKB	Natural variant	645	1037	.	.	.	ID=VAR_086239;Note=In VISS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33875846;Dbxref=PMID:33875846	
O15397	UniProtKB	Natural variant	710	1037	.	.	.	ID=VAR_086240;Note=In VISS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34010604;Dbxref=PMID:34010604	
O15397	UniProtKB	Natural variant	749	749	.	.	.	ID=VAR_086241;Note=In VISS%3B undetectable protein expression levels in either patient's fibroblasts or patient's Epstein-Barr virus-immortalized B cell lines. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34010604;Dbxref=PMID:34010604	
O15397	UniProtKB	Natural variant	803	1037	.	.	.	ID=VAR_086242;Note=In VISS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34010604;Dbxref=PMID:34010604	
O15397	UniProtKB	Natural variant	834	834	.	.	.	ID=VAR_086243;Note=In VISS%3B very low protein expression levels%2C if any%2C in either patient's fibroblasts or patient's Epstein-Barr virus-immortalized B cell lines. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34010604;Dbxref=dbSNP:rs1425433912,PMID:34010604	
O15397	UniProtKB	Sequence conflict	91	91	.	.	.	Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O15397	UniProtKB	Sequence conflict	279	279	.	.	.	Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305