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Protein

Importin-8

Gene

IPO8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.2 Publications

GO - Molecular functioni

  • Ran GTPase binding Source: ProtInc

GO - Biological processi

  • gene expression Source: Reactome
  • intracellular protein transport Source: InterPro
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_268530. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-8
Short name:
Imp8
Alternative name(s):
Ran-binding protein 8
Short name:
RanBP8
Gene namesi
Name:IPO8
Synonyms:RANBP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9853. IPO8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34214.

Polymorphism and mutation databases

BioMutaiIPO8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10371037Importin-8PRO_0000120752Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei902 – 9021Phosphoserine3 Publications
Modified residuei903 – 9031Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15397.
PaxDbiO15397.
PRIDEiO15397.

PTM databases

PhosphoSiteiO15397.

Expressioni

Gene expression databases

BgeeiO15397.
CleanExiHS_IPO8.
ExpressionAtlasiO15397. baseline and differential.
GenevisibleiO15397. HS.

Organism-specific databases

HPAiHPA018439.
HPA023765.

Interactioni

Subunit structurei

Forms a heterodimer with KPNB1. Interacts with SRP19. Binds directly to nuclear pore complexes.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AGO1Q9UL182EBI-358808,EBI-527363
AGO2Q9UKV84EBI-358808,EBI-528269
AGO3Q9H9G75EBI-358808,EBI-2267883
AGO4Q9HCK53EBI-358808,EBI-2269696

Protein-protein interaction databases

BioGridi115781. 26 interactions.
IntActiO15397. 10 interactions.
MINTiMINT-1150774.
STRINGi9606.ENSP00000256079.

Structurei

3D structure databases

ProteinModelPortaliO15397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 10281Importin N-terminalPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi923 – 9286Poly-Glu

Sequence similaritiesi

Belongs to the importin beta family.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5656.
GeneTreeiENSGT00550000074736.
HOGENOMiHOG000006586.
HOVERGENiHBG006824.
InParanoidiO15397.
KOiK18755.
OMAiISNQTQA.
OrthoDBiEOG7TF787.
PhylomeDBiO15397.
TreeFamiTF300634.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013713. Cse1.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF08506. Cse1. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15397-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLNRIIQAL KGTIDPKLRI AAENELNQSY KIINFAPSLL RIIVSDHVEF
60 70 80 90 100
PVRQAAAIYL KNMVTQYWPD REPPPGEAIF PFNIHENDRQ QIRDNIVEGI
110 120 130 140 150
IRSPDLVRVQ LTMCLRAIIK HDFPGHWPGV VDKIDYYLQS QSSASWLGSL
160 170 180 190 200
LCLYQLVKTY EYKKAEEREP LIIAMQIFLP RIQQQIVQLL PDSSYYSVLL
210 220 230 240 250
QKQILKIFYA LVQYALPLQL VNNQTMTTWM EIFRTIIDRT VPPETLHIDE
260 270 280 290 300
DDRPELVWWK CKKWALHIVA RLFERYGSPG NVTKEYFEFS EFFLKTYAVG
310 320 330 340 350
IQQVLLKILD QYRQKEYVAP RVLQQAFNYL NQGVVHSITW KQMKPHIQNI
360 370 380 390 400
SEDVIFSVMC YKDEDEELWQ EDPYEYIRMK FDIFEDYASP TTAAQTLLYT
410 420 430 440 450
AAKKRKEVLP KMMAFCYQIL TDPNFDPRKK DGALHVIGSL AEILLKKSLF
460 470 480 490 500
KDQMELFLQN HVFPLLLSNL GYLRARSCWV LHAFSSLKFH NELNLRNAVE
510 520 530 540 550
LAKKSLIEDK EMPVKVEAAL ALQSLISNQI QAKEYMKPHV RPIMQELLHI
560 570 580 590 600
VRETENDDVT NVIQKMICEY SQEVASIAVD MTQHLAEIFG KVLQSDEYEE
610 620 630 640 650
VEDKTVMAMG ILHTIDTILT VVEDHKEITQ QLENICLRII DLVLQKHVIE
660 670 680 690 700
FYEEILSLAY SLTCHSISPQ MWQLLGILYE VFQQDCFEYF TDMMPLLHNY
710 720 730 740 750
VTIDTDTLLS NAKHLEILFT MCRKVLCGDA GEDAECHAAK LLEVIILQCK
760 770 780 790 800
GRGIDQCIPL FVQLVLERLT RGVKTSELRT MCLQVAIAAL YYNPDLLLHT
810 820 830 840 850
LERIQLPHNP GPITVQFINQ WMNDTDCFLG HHDRKMCIIG LSILLELQNR
860 870 880 890 900
PPAVDAVVGQ IVPSILFLFL GLKQVCATRQ LVNREDRSKA EKADMEENEE
910 920 930 940 950
ISSDEEETNV TAQAMQSNNG RGEDEEEEDD DWDEEVLEET ALEGFSTPLD
960 970 980 990 1000
LDNSVDEYQF FTQALITVQS RDAAWYQLLM APLSEDQRTA LQEVYTLAEH
1010 1020 1030
RRTVAEAKKK IEQQGGFTFE NKGVLSAFNF GTVPSNN
Length:1,037
Mass (Da):119,938
Last modified:May 5, 2009 - v2
Checksum:i3D7195FD57D7D9AF
GO
Isoform 2 (identifier: O15397-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-213: MDLNRIIQAL...ILKIFYALVQ → MESLTLKG

Note: No experimental confirmation available.
Show »
Length:832
Mass (Da):96,036
Checksum:i1E6B417A8C7B7311
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911Q → R in AAB67052 (PubMed:9214382).Curated
Sequence conflicti279 – 2791P → A in AAB67052 (PubMed:9214382).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61I → F.1 Publication
Corresponds to variant rs1054423 [ dbSNP | Ensembl ].
VAR_055118
Natural varianti640 – 6401I → V.
Corresponds to variant rs34119940 [ dbSNP | Ensembl ].
VAR_055119

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 213213MDLNR…YALVQ → MESLTLKG in isoform 2. 1 PublicationVSP_042574Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77494 mRNA. Translation: AAB67052.1.
AK302260 mRNA. Translation: BAH13659.1.
AC012673 Genomic DNA. No translation available.
AC023426 Genomic DNA. No translation available.
CCDSiCCDS53773.1. [O15397-2]
CCDS8719.1. [O15397-1]
RefSeqiNP_001177924.1. NM_001190995.1. [O15397-2]
NP_006381.2. NM_006390.3. [O15397-1]
UniGeneiHs.505136.

Genome annotation databases

EnsembliENST00000256079; ENSP00000256079; ENSG00000133704. [O15397-1]
ENST00000544829; ENSP00000444520; ENSG00000133704. [O15397-2]
GeneIDi10526.
KEGGihsa:10526.
UCSCiuc001rjd.3. human. [O15397-1]
uc001rje.1. human. [O15397-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77494 mRNA. Translation: AAB67052.1.
AK302260 mRNA. Translation: BAH13659.1.
AC012673 Genomic DNA. No translation available.
AC023426 Genomic DNA. No translation available.
CCDSiCCDS53773.1. [O15397-2]
CCDS8719.1. [O15397-1]
RefSeqiNP_001177924.1. NM_001190995.1. [O15397-2]
NP_006381.2. NM_006390.3. [O15397-1]
UniGeneiHs.505136.

3D structure databases

ProteinModelPortaliO15397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115781. 26 interactions.
IntActiO15397. 10 interactions.
MINTiMINT-1150774.
STRINGi9606.ENSP00000256079.

PTM databases

PhosphoSiteiO15397.

Polymorphism and mutation databases

BioMutaiIPO8.

Proteomic databases

MaxQBiO15397.
PaxDbiO15397.
PRIDEiO15397.

Protocols and materials databases

DNASUi10526.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256079; ENSP00000256079; ENSG00000133704. [O15397-1]
ENST00000544829; ENSP00000444520; ENSG00000133704. [O15397-2]
GeneIDi10526.
KEGGihsa:10526.
UCSCiuc001rjd.3. human. [O15397-1]
uc001rje.1. human. [O15397-2]

Organism-specific databases

CTDi10526.
GeneCardsiGC12M030682.
HGNCiHGNC:9853. IPO8.
HPAiHPA018439.
HPA023765.
MIMi605600. gene.
neXtProtiNX_O15397.
PharmGKBiPA34214.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5656.
GeneTreeiENSGT00550000074736.
HOGENOMiHOG000006586.
HOVERGENiHBG006824.
InParanoidiO15397.
KOiK18755.
OMAiISNQTQA.
OrthoDBiEOG7TF787.
PhylomeDBiO15397.
TreeFamiTF300634.

Enzyme and pathway databases

ReactomeiREACT_268530. Transcriptional regulation by small RNAs.

Miscellaneous databases

GenomeRNAii10526.
NextBioi39934.
PROiO15397.
SOURCEiSearch...

Gene expression databases

BgeeiO15397.
CleanExiHS_IPO8.
ExpressionAtlasiO15397. baseline and differential.
GenevisibleiO15397. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013713. Cse1.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF08506. Cse1. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH KPNB1, VARIANT PHE-6.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin."
    Dean K.A., von Ahsen O., Goerlich D., Fried H.M.
    J. Cell Sci. 114:3479-3485(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SRP19.
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902 AND SER-903, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902 AND SER-903, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902 AND SER-903, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIPO8_HUMAN
AccessioniPrimary (citable) accession number: O15397
Secondary accession number(s): B7Z7M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: May 5, 2009
Last modified: June 24, 2015
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.