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O15397

- IPO8_HUMAN

UniProt

O15397 - IPO8_HUMAN

Protein

Importin-8

Gene

IPO8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. Ran GTPase binding Source: ProtInc

    GO - Biological processi

    1. intracellular protein transport Source: InterPro
    2. signal transduction Source: ProtInc

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Importin-8
    Short name:
    Imp8
    Alternative name(s):
    Ran-binding protein 8
    Short name:
    RanBP8
    Gene namesi
    Name:IPO8
    Synonyms:RANBP8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:9853. IPO8.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34214.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10371037Importin-8PRO_0000120752Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei902 – 9021Phosphoserine3 Publications
    Modified residuei903 – 9031Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO15397.
    PaxDbiO15397.
    PRIDEiO15397.

    PTM databases

    PhosphoSiteiO15397.

    Expressioni

    Gene expression databases

    ArrayExpressiO15397.
    BgeeiO15397.
    CleanExiHS_IPO8.
    GenevestigatoriO15397.

    Organism-specific databases

    HPAiHPA018439.
    HPA023765.

    Interactioni

    Subunit structurei

    Forms a heterodimer with KPNB1. Interacts with SRP19. Binds directly to nuclear pore complexes.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AGO1Q9UL182EBI-358808,EBI-527363
    AGO2Q9UKV84EBI-358808,EBI-528269
    AGO3Q9H9G75EBI-358808,EBI-2267883
    AGO4Q9HCK53EBI-358808,EBI-2269696

    Protein-protein interaction databases

    BioGridi115781. 14 interactions.
    IntActiO15397. 10 interactions.
    MINTiMINT-1150774.
    STRINGi9606.ENSP00000256079.

    Structurei

    3D structure databases

    ProteinModelPortaliO15397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 10281Importin N-terminalPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi923 – 9286Poly-Glu

    Sequence similaritiesi

    Belongs to the importin beta family.Curated
    Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5656.
    HOGENOMiHOG000006586.
    HOVERGENiHBG006824.
    InParanoidiO15397.
    OMAiIQAKEYM.
    OrthoDBiEOG7TF787.
    PhylomeDBiO15397.
    TreeFamiTF300634.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013713. Cse1.
    IPR001494. Importin-beta_N.
    [Graphical view]
    PfamiPF08506. Cse1. 1 hit.
    PF03810. IBN_N. 1 hit.
    [Graphical view]
    SMARTiSM00913. IBN_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O15397-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLNRIIQAL KGTIDPKLRI AAENELNQSY KIINFAPSLL RIIVSDHVEF     50
    PVRQAAAIYL KNMVTQYWPD REPPPGEAIF PFNIHENDRQ QIRDNIVEGI 100
    IRSPDLVRVQ LTMCLRAIIK HDFPGHWPGV VDKIDYYLQS QSSASWLGSL 150
    LCLYQLVKTY EYKKAEEREP LIIAMQIFLP RIQQQIVQLL PDSSYYSVLL 200
    QKQILKIFYA LVQYALPLQL VNNQTMTTWM EIFRTIIDRT VPPETLHIDE 250
    DDRPELVWWK CKKWALHIVA RLFERYGSPG NVTKEYFEFS EFFLKTYAVG 300
    IQQVLLKILD QYRQKEYVAP RVLQQAFNYL NQGVVHSITW KQMKPHIQNI 350
    SEDVIFSVMC YKDEDEELWQ EDPYEYIRMK FDIFEDYASP TTAAQTLLYT 400
    AAKKRKEVLP KMMAFCYQIL TDPNFDPRKK DGALHVIGSL AEILLKKSLF 450
    KDQMELFLQN HVFPLLLSNL GYLRARSCWV LHAFSSLKFH NELNLRNAVE 500
    LAKKSLIEDK EMPVKVEAAL ALQSLISNQI QAKEYMKPHV RPIMQELLHI 550
    VRETENDDVT NVIQKMICEY SQEVASIAVD MTQHLAEIFG KVLQSDEYEE 600
    VEDKTVMAMG ILHTIDTILT VVEDHKEITQ QLENICLRII DLVLQKHVIE 650
    FYEEILSLAY SLTCHSISPQ MWQLLGILYE VFQQDCFEYF TDMMPLLHNY 700
    VTIDTDTLLS NAKHLEILFT MCRKVLCGDA GEDAECHAAK LLEVIILQCK 750
    GRGIDQCIPL FVQLVLERLT RGVKTSELRT MCLQVAIAAL YYNPDLLLHT 800
    LERIQLPHNP GPITVQFINQ WMNDTDCFLG HHDRKMCIIG LSILLELQNR 850
    PPAVDAVVGQ IVPSILFLFL GLKQVCATRQ LVNREDRSKA EKADMEENEE 900
    ISSDEEETNV TAQAMQSNNG RGEDEEEEDD DWDEEVLEET ALEGFSTPLD 950
    LDNSVDEYQF FTQALITVQS RDAAWYQLLM APLSEDQRTA LQEVYTLAEH 1000
    RRTVAEAKKK IEQQGGFTFE NKGVLSAFNF GTVPSNN 1037
    Length:1,037
    Mass (Da):119,938
    Last modified:May 5, 2009 - v2
    Checksum:i3D7195FD57D7D9AF
    GO
    Isoform 2 (identifier: O15397-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-213: MDLNRIIQAL...ILKIFYALVQ → MESLTLKG

    Note: No experimental confirmation available.

    Show »
    Length:832
    Mass (Da):96,036
    Checksum:i1E6B417A8C7B7311
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911Q → R in AAB67052. (PubMed:9214382)Curated
    Sequence conflicti279 – 2791P → A in AAB67052. (PubMed:9214382)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61I → F.1 Publication
    Corresponds to variant rs1054423 [ dbSNP | Ensembl ].
    VAR_055118
    Natural varianti640 – 6401I → V.
    Corresponds to variant rs34119940 [ dbSNP | Ensembl ].
    VAR_055119

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 213213MDLNR…YALVQ → MESLTLKG in isoform 2. 1 PublicationVSP_042574Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77494 mRNA. Translation: AAB67052.1.
    AK302260 mRNA. Translation: BAH13659.1.
    AC012673 Genomic DNA. No translation available.
    AC023426 Genomic DNA. No translation available.
    CCDSiCCDS53773.1. [O15397-2]
    CCDS8719.1. [O15397-1]
    RefSeqiNP_001177924.1. NM_001190995.1. [O15397-2]
    NP_006381.2. NM_006390.3. [O15397-1]
    UniGeneiHs.505136.

    Genome annotation databases

    EnsembliENST00000256079; ENSP00000256079; ENSG00000133704. [O15397-1]
    ENST00000544829; ENSP00000444520; ENSG00000133704. [O15397-2]
    GeneIDi10526.
    KEGGihsa:10526.
    UCSCiuc001rjd.3. human. [O15397-1]
    uc001rje.1. human. [O15397-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77494 mRNA. Translation: AAB67052.1 .
    AK302260 mRNA. Translation: BAH13659.1 .
    AC012673 Genomic DNA. No translation available.
    AC023426 Genomic DNA. No translation available.
    CCDSi CCDS53773.1. [O15397-2 ]
    CCDS8719.1. [O15397-1 ]
    RefSeqi NP_001177924.1. NM_001190995.1. [O15397-2 ]
    NP_006381.2. NM_006390.3. [O15397-1 ]
    UniGenei Hs.505136.

    3D structure databases

    ProteinModelPortali O15397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115781. 14 interactions.
    IntActi O15397. 10 interactions.
    MINTi MINT-1150774.
    STRINGi 9606.ENSP00000256079.

    PTM databases

    PhosphoSitei O15397.

    Proteomic databases

    MaxQBi O15397.
    PaxDbi O15397.
    PRIDEi O15397.

    Protocols and materials databases

    DNASUi 10526.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256079 ; ENSP00000256079 ; ENSG00000133704 . [O15397-1 ]
    ENST00000544829 ; ENSP00000444520 ; ENSG00000133704 . [O15397-2 ]
    GeneIDi 10526.
    KEGGi hsa:10526.
    UCSCi uc001rjd.3. human. [O15397-1 ]
    uc001rje.1. human. [O15397-2 ]

    Organism-specific databases

    CTDi 10526.
    GeneCardsi GC12M030682.
    HGNCi HGNC:9853. IPO8.
    HPAi HPA018439.
    HPA023765.
    MIMi 605600. gene.
    neXtProti NX_O15397.
    PharmGKBi PA34214.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5656.
    HOGENOMi HOG000006586.
    HOVERGENi HBG006824.
    InParanoidi O15397.
    OMAi IQAKEYM.
    OrthoDBi EOG7TF787.
    PhylomeDBi O15397.
    TreeFami TF300634.

    Miscellaneous databases

    GenomeRNAii 10526.
    NextBioi 39934.
    PROi O15397.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15397.
    Bgeei O15397.
    CleanExi HS_IPO8.
    Genevestigatori O15397.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013713. Cse1.
    IPR001494. Importin-beta_N.
    [Graphical view ]
    Pfami PF08506. Cse1. 1 hit.
    PF03810. IBN_N. 1 hit.
    [Graphical view ]
    SMARTi SM00913. IBN_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50166. IMPORTIN_B_NT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH KPNB1, VARIANT PHE-6.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin."
      Dean K.A., von Ahsen O., Goerlich D., Fried H.M.
      J. Cell Sci. 114:3479-3485(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SRP19.
    5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902 AND SER-903, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902 AND SER-903, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902 AND SER-903, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIPO8_HUMAN
    AccessioniPrimary (citable) accession number: O15397
    Secondary accession number(s): B7Z7M3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3