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O15394

- NCAM2_HUMAN

UniProt

O15394 - NCAM2_HUMAN

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Protein
Neural cell adhesion molecule 2
Gene
NCAM2, NCAM21
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.

GO - Biological processi

  1. axonal fasciculation Source: Ensembl
  2. neuron cell-cell adhesion Source: ProtInc
  3. sensory perception of smell Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Neural cell adhesion molecule 2
Short name:
N-CAM-2
Short name:
NCAM-2
Gene namesi
Name:NCAM2
Synonyms:NCAM21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:7657. NCAM2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 697678Extracellular Reviewed prediction
Add
BLAST
Transmembranei698 – 71821Helical; Reviewed prediction
Add
BLAST
Topological domaini719 – 837119Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon Source: Ensembl
  2. integral component of membrane Source: ProtInc
  3. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 837818Neural cell adhesion molecule 2
PRO_0000015018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 93 Inferred
Disulfide bondi136 ↔ 186 Inferred
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi219 – 2191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi232 ↔ 281 Inferred
Glycosylationi309 – 3091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi322 ↔ 380 Inferred
Glycosylationi406 – 4061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi419 – 4191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi422 ↔ 475 Inferred
Glycosylationi445 – 4451N-linked (GlcNAc...)1 Publication
Glycosylationi474 – 4741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi562 – 5621N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO15394.
PaxDbiO15394.
PRIDEiO15394.

PTM databases

PhosphoSiteiO15394.

Expressioni

Tissue specificityi

Expressed most strongly in adult and fetal brain.

Gene expression databases

ArrayExpressiO15394.
BgeeiO15394.
CleanExiHS_NCAM2.
GenevestigatoriO15394.

Organism-specific databases

HPAiHPA030900.

Interactioni

Protein-protein interaction databases

BioGridi110765. 2 interactions.
DIPiDIP-56211N.
IntActiO15394. 2 interactions.
STRINGi9606.ENSP00000383392.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi20 – 267
Beta strandi28 – 336
Beta strandi38 – 469
Beta strandi49 – 546
Beta strandi65 – 728
Beta strandi75 – 806
Helixi85 – 873
Beta strandi89 – 968
Beta strandi98 – 1003
Beta strandi102 – 11211
Beta strandi116 – 1194
Beta strandi123 – 1275
Beta strandi132 – 1343
Beta strandi137 – 1393
Beta strandi145 – 1506
Beta strandi152 – 1543
Beta strandi163 – 1653
Beta strandi171 – 1733
Helixi178 – 1803
Beta strandi182 – 1909
Turni191 – 1944
Beta strandi195 – 20612
Beta strandi210 – 2123
Beta strandi217 – 2215
Beta strandi222 – 2243
Beta strandi228 – 2314
Beta strandi233 – 2353
Beta strandi241 – 2466
Beta strandi254 – 2607
Turni261 – 2644
Beta strandi265 – 2684
Helixi273 – 2753
Beta strandi277 – 2859
Beta strandi288 – 30720
Beta strandi310 – 3123
Beta strandi317 – 32812
Beta strandi331 – 3366
Turni337 – 3404
Beta strandi341 – 3433
Beta strandi350 – 3523
Beta strandi354 – 3596
Beta strandi362 – 3698
Helixi372 – 3743
Beta strandi376 – 3849
Beta strandi387 – 39711
Beta strandi409 – 4124
Beta strandi418 – 4225
Beta strandi424 – 4285
Beta strandi431 – 4366
Beta strandi439 – 4424
Beta strandi449 – 4535
Beta strandi458 – 4625
Beta strandi469 – 47911
Beta strandi482 – 49211
Beta strandi500 – 5078
Beta strandi512 – 5176
Beta strandi527 – 53610
Beta strandi543 – 5464
Beta strandi548 – 5503
Beta strandi552 – 5565
Beta strandi564 – 57512
Beta strandi576 – 5805
Beta strandi584 – 5874
Beta strandi599 – 6046
Turni605 – 6073
Beta strandi608 – 6136
Beta strandi619 – 6213
Beta strandi625 – 6317
Beta strandi640 – 6456
Turni646 – 6483
Beta strandi650 – 6534
Beta strandi661 – 67010
Beta strandi678 – 6836

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DOCNMR-A486-591[»]
2JLLX-ray2.30A301-689[»]
2KBGNMR-A592-693[»]
2V5TX-ray2.00A115-301[»]
2VAJX-ray2.70A21-113[»]
2WIMX-ray3.00A/B19-301[»]
2XY1X-ray1.90A209-398[»]
2XY2X-ray1.77A19-207[»]
2XYCX-ray2.65A301-591[»]
ProteinModelPortaliO15394.
SMRiO15394. Positions 19-693.

Miscellaneous databases

EvolutionaryTraceiO15394.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 10888Ig-like C2-type 1
Add
BLAST
Domaini113 – 20290Ig-like C2-type 2
Add
BLAST
Domaini208 – 29790Ig-like C2-type 3
Add
BLAST
Domaini302 – 39695Ig-like C2-type 4
Add
BLAST
Domaini401 – 49191Ig-like C2-type 5
Add
BLAST
Domaini498 – 59194Fibronectin type-III 1
Add
BLAST
Domaini593 – 68896Fibronectin type-III 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308439.
HOGENOMiHOG000074124.
HOVERGENiHBG052579.
InParanoidiO15394.
KOiK06491.
OMAiEPTISWY.
OrthoDBiEOG75MVVH.
PhylomeDBiO15394.
TreeFamiTF326195.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR009138. Neural_cell_adh.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view]
PRINTSiPR01838. NCAMFAMILY.
SMARTiSM00060. FN3. 2 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15394-1 [UniParc]FASTAAdd to Basket

« Hide

MSLLLSFYLL GLLVSSGQAL LQVTISLSKV ELSVGESKFF TCTAIGEPES    50
IDWYNPQGEK IISTQRVVVQ KEGVRSRLTI YNANIEDAGI YRCQATDAKG 100
QTQEATVVLE IYQKLTFREV VSPQEFKQGE DAEVVCRVSS SPAPAVSWLY 150
HNEEVTTISD NRFAMLANNN LQILNINKSD EGIYRCEGRV EARGEIDFRD 200
IIVIVNVPPA ISMPQKSFNA TAERGEEMTF SCRASGSPEP AISWFRNGKL 250
IEENEKYILK GSNTELTVRN IINSDGGPYV CRATNKAGED EKQAFLQVFV 300
QPHIIQLKNE TTYENGQVTL VCDAEGEPIP EITWKRAVDG FTFTEGDKSL 350
DGRIEVKGQH GSSSLHIKDV KLSDSGRYDC EAASRIGGHQ KSMYLDIEYA 400
PKFISNQTIY YSWEGNPINI SCDVKSNPPA SIHWRRDKLV LPAKNTTNLK 450
TYSTGRKMIL EIAPTSDNDF GRYNCTATNH IGTRFQEYIL ALADVPSSPY 500
GVKIIELSQT TAKVSFNKPD SHGGVPIHHY QVDVKEVASE IWKIVRSHGV 550
QTMVVLNNLE PNTTYEIRVA AVNGKGQGDY SKIEIFQTLP VREPSPPSIH 600
GQPSSGKSFK LSITKQDDGG APILEYIVKY RSKDKEDQWL EKKVQGNKDH 650
IILEHLQWTM GYEVQITAAN RLGYSEPTVY EFSMPPKPNI IKDTLFNGLG 700
LGAVIGLGVA ALLLILVVTD VSCFFIRQCG LLMCITRRMC GKKSGSSGKS 750
KELEEGKAAY LKDGSKEPIV EMRTEDERVT NHEDGSPVNE PNETTPLTEP 800
EKLPLKEEDG KEALNPETIE IKVSNDIIQS KEDDSKA 837
Length:837
Mass (Da):93,046
Last modified:July 22, 2008 - v2
Checksum:i878EC1110562B3F3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti347 – 3471D → N.
Corresponds to variant rs35654962 [ dbSNP | Ensembl ].
VAR_047897
Natural varianti350 – 3501L → P.1 Publication
Corresponds to variant rs232518 [ dbSNP | Ensembl ].
VAR_047898

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491E → R in AAB80803. 1 Publication
Sequence conflicti72 – 721E → G in AAB80803. 1 Publication
Sequence conflicti163 – 1631F → L in AAB80803. 1 Publication
Sequence conflicti374 – 3741D → G in AAB80803. 1 Publication
Sequence conflicti662 – 6676YEVQIT → MKFRLP in AAB80803. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U75330 mRNA. Translation: AAB80803.1.
AP001138 Genomic DNA. No translation available.
BC052946 mRNA. Translation: AAH52946.1.
CCDSiCCDS42910.1.
RefSeqiNP_004531.2. NM_004540.3.
UniGeneiHs.473450.

Genome annotation databases

EnsembliENST00000400546; ENSP00000383392; ENSG00000154654.
GeneIDi4685.
KEGGihsa:4685.
UCSCiuc002yld.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U75330 mRNA. Translation: AAB80803.1 .
AP001138 Genomic DNA. No translation available.
BC052946 mRNA. Translation: AAH52946.1 .
CCDSi CCDS42910.1.
RefSeqi NP_004531.2. NM_004540.3.
UniGenei Hs.473450.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DOC NMR - A 486-591 [» ]
2JLL X-ray 2.30 A 301-689 [» ]
2KBG NMR - A 592-693 [» ]
2V5T X-ray 2.00 A 115-301 [» ]
2VAJ X-ray 2.70 A 21-113 [» ]
2WIM X-ray 3.00 A/B 19-301 [» ]
2XY1 X-ray 1.90 A 209-398 [» ]
2XY2 X-ray 1.77 A 19-207 [» ]
2XYC X-ray 2.65 A 301-591 [» ]
ProteinModelPortali O15394.
SMRi O15394. Positions 19-693.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110765. 2 interactions.
DIPi DIP-56211N.
IntActi O15394. 2 interactions.
STRINGi 9606.ENSP00000383392.

PTM databases

PhosphoSitei O15394.

Proteomic databases

MaxQBi O15394.
PaxDbi O15394.
PRIDEi O15394.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000400546 ; ENSP00000383392 ; ENSG00000154654 .
GeneIDi 4685.
KEGGi hsa:4685.
UCSCi uc002yld.2. human.

Organism-specific databases

CTDi 4685.
GeneCardsi GC21P022370.
H-InvDB HIX0027799.
HGNCi HGNC:7657. NCAM2.
HPAi HPA030900.
MIMi 602040. gene.
neXtProti NX_O15394.
PharmGKBi PA31460.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG308439.
HOGENOMi HOG000074124.
HOVERGENi HBG052579.
InParanoidi O15394.
KOi K06491.
OMAi EPTISWY.
OrthoDBi EOG75MVVH.
PhylomeDBi O15394.
TreeFami TF326195.

Miscellaneous databases

ChiTaRSi NCAM2. human.
EvolutionaryTracei O15394.
GenomeRNAii 4685.
NextBioi 18068.
PROi O15394.
SOURCEi Search...

Gene expression databases

ArrayExpressi O15394.
Bgeei O15394.
CleanExi HS_NCAM2.
Genevestigatori O15394.

Family and domain databases

Gene3Di 2.60.40.10. 7 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR009138. Neural_cell_adh.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view ]
PRINTSi PR01838. NCAMFAMILY.
SMARTi SM00060. FN3. 2 hits.
SM00408. IGc2. 5 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
PROSITEi PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndrome."
    Paoloni-Giacobino A., Chen H., Antonarakis S.E.
    Genomics 43:43-51(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-350.
    Tissue: Brain.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
    Zhang H., Li X.-J., Martin D.B., Aebersold R.
    Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-445 AND ASN-562.
  5. "Solution structure of the fibronectin type-III domain of human neural cell adhesion molecule 2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 486-591.

Entry informationi

Entry nameiNCAM2_HUMAN
AccessioniPrimary (citable) accession number: O15394
Secondary accession number(s): A8MQ06, Q7Z7F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 22, 2008
Last modified: September 3, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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