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Protein

Sialic acid-binding Ig-like lectin 5

Gene

SIGLEC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei119Sialic acid1 Publication1
Binding sitei127Sialic acid1 Publication1
Binding sitei129Sialic acid1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid-binding Ig-like lectin 5
Short name:
Siglec-5
Alternative name(s):
CD33 antigen-like 2
Obesity-binding protein 2
Short name:
OB-BP2
Short name:
OB-binding protein 2
CD_antigen: CD170
Gene namesi
Name:SIGLEC5
Synonyms:CD33L2, OBBP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105501.11.
HGNCiHGNC:10874. SIGLEC5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 441ExtracellularSequence analysisAdd BLAST425
Transmembranei442 – 462HelicalSequence analysisAdd BLAST21
Topological domaini463 – 551CytoplasmicSequence analysisAdd BLAST89

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8778.
OpenTargetsiENSG00000105501.
ENSG00000268500.
PharmGKBiPA35775.

Polymorphism and mutation databases

BioMutaiSIGLEC5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001494417 – 551Sialic acid-binding Ig-like lectin 5Add BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 170PROSITE-ProRule annotation1 Publication
Disulfide bondi41 ↔ 101PROSITE-ProRule annotation1 Publication
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi164 ↔ 213PROSITE-ProRule annotation1 Publication
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi269 ↔ 314PROSITE-ProRule annotation
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi384N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO15389.
PaxDbiO15389.
PeptideAtlasiO15389.
PRIDEiO15389.

PTM databases

iPTMnetiO15389.
PhosphoSitePlusiO15389.

Expressioni

Tissue specificityi

Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

Gene expression databases

BgeeiENSG00000105501.
CleanExiHS_SIGLEC5.
GenevisibleiO15389. HS.

Organism-specific databases

HPAiCAB024900.
HPA009085.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114308. 12 interactors.
IntActiO15389. 3 interactors.
MINTiMINT-1445881.
STRINGi9606.ENSP00000455510.

Structurei

Secondary structure

1551
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 24Combined sources3
Beta strandi27 – 32Combined sources6
Beta strandi37 – 39Combined sources3
Beta strandi42 – 44Combined sources3
Beta strandi56 – 62Combined sources7
Helixi67 – 69Combined sources3
Beta strandi72 – 76Combined sources5
Beta strandi78 – 80Combined sources3
Turni84 – 89Combined sources6
Beta strandi90 – 92Combined sources3
Helixi96 – 98Combined sources3
Beta strandi103 – 105Combined sources3
Helixi110 – 112Combined sources3
Beta strandi114 – 122Combined sources9
Turni123 – 125Combined sources3
Beta strandi126 – 129Combined sources4
Beta strandi135 – 140Combined sources6
Beta strandi147 – 149Combined sources3
Beta strandi160 – 165Combined sources6
Beta strandi171 – 174Combined sources4
Beta strandi177 – 183Combined sources7
Beta strandi186 – 188Combined sources3
Turni190 – 193Combined sources4
Beta strandi195 – 200Combined sources6
Turni204 – 208Combined sources5
Beta strandi210 – 216Combined sources7
Beta strandi225 – 229Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZG1X-ray2.70A20-233[»]
2ZG2X-ray2.85A20-233[»]
2ZG3X-ray3.00A20-233[»]
ProteinModelPortaliO15389.
SMRiO15389.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15389.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 136Ig-like V-typeAdd BLAST118
Domaini146 – 229Ig-like C2-type 1Add BLAST84
Domaini236 – 330Ig-like C2-type 2Add BLAST95

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi518 – 523ITIM motif6
Motifi542 – 547SLAM-like motif6

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJT6. Eukaryota.
ENOG410YKZU. LUCA.
GeneTreeiENSGT00760000119139.
HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiO15389.
KOiK06549.
OMAiCWWLGEK.
OrthoDBiEOG091G06ZM.
PhylomeDBiO15389.
TreeFamiTF332441.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15389-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLLLLPLL WGGSLQEKPV YELQVQKSVT VQEGLCVLVP CSFSYPWRSW
60 70 80 90 100
YSSPPLYVYW FRDGEIPYYA EVVATNNPDR RVKPETQGRF RLLGDVQKKN
110 120 130 140 150
CSLSIGDARM EDTGSYFFRV ERGRDVKYSY QQNKLNLEVT ALIEKPDIHF
160 170 180 190 200
LEPLESGRPT RLSCSLPGSC EAGPPLTFSW TGNALSPLDP ETTRSSELTL
210 220 230 240 250
TPRPEDHGTN LTCQMKRQGA QVTTERTVQL NVSYAPQTIT IFRNGIALEI
260 270 280 290 300
LQNTSYLPVL EGQALRLLCD APSNPPAHLS WFQGSPALNA TPISNTGILE
310 320 330 340 350
LRRVRSAEEG GFTCRAQHPL GFLQIFLNLS VYSLPQLLGP SCSWEAEGLH
360 370 380 390 400
CRCSFRARPA PSLCWRLEEK PLEGNSSQGS FKVNSSSAGP WANSSLILHG
410 420 430 440 450
GLSSDLKVSC KAWNIYGSQS GSVLLLQGRS NLGTGVVPAA LGGAGVMALL
460 470 480 490 500
CICLCLIFFL IVKARRKQAA GRPEKMDDED PIMGTITSGS RKKPWPDSPG
510 520 530 540 550
DQASPPGDAP PLEEQKELHY ASLSFSEMKS REPKDQEAPS TTEYSEIKTS

K
Length:551
Mass (Da):60,715
Last modified:January 1, 1998 - v1
Checksum:i2FEA2B6B341EFEAF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti309E → K in AAD50978 (PubMed:9731071).Curated1
Sequence conflicti388A → P in AAD50978 (PubMed:9731071).Curated1
Sequence conflicti403S → N in AAD50978 (PubMed:9731071).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01424972V → A. Corresponds to variant dbSNP:rs1973019Ensembl.1
Natural variantiVAR_014250215M → V. Corresponds to variant dbSNP:rs1807124Ensembl.1
Natural variantiVAR_014251322F → S. Corresponds to variant dbSNP:rs2278831Ensembl.1
Natural variantiVAR_049929358R → W1 PublicationCorresponds to variant dbSNP:rs8108074Ensembl.1
Natural variantiVAR_020087499P → A1 PublicationCorresponds to variant dbSNP:rs3829655Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170484 mRNA. Translation: AAD50978.1.
U71383 mRNA. Translation: AAB70703.1.
AC018755 Genomic DNA. Translation: AAF87846.1.
BC029896 mRNA. Translation: AAH29896.1.
CCDSiCCDS33088.1.
RefSeqiNP_003821.1. NM_003830.3.
UniGeneiHs.310333.

Genome annotation databases

EnsembliENST00000534261; ENSP00000473238; ENSG00000105501.
GeneIDi8778.
KEGGihsa:8778.
UCSCiuc002pxe.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSIGL5_HUMAN
AccessioniPrimary (citable) accession number: O15389
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: January 1, 1998
Last modified: September 27, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families