O15385 (O15385_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: NAD (H)-specific isocitrate dehydrogenase gamma subunit EMBL AAB70116.1
Organism	Homo sapiens (Human) EMBL AAB70116.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	210 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Ontologies

Keywords
Molecular function	Oxidoreductase RuleBase RU004444
Gene Ontology (GO)
Cellular_component	mitochondrion Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular_function	NAD binding Inferred from electronic annotation. Source: InterPro isocitrate dehydrogenase (NAD+) activity Non-traceable author statement Ref.1. Source: UniProtKB magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAB70116.1

Sequences

	Sequence		Length	Mass (Da)
	O15385 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 2F83A837F5A59B1B	FASTA	210	22,706
	10 20 30 40 50 60 KSLRIAEYAF KLAQESGRKK VTAVHKANIM KLGDGLFLQC CREVAARYPQ ITFENMIVDN 70 80 90 100 110 120 TTMQLVSRPQ QFDVMVMPNL YGNIVNNVCA GLVGGPGLVA GANYGHVYAV FETATRNTGK 130 140 150 160 170 180 SIANKNIANP TATLLASCMM LDHLKLHSYA TSIRKAVLAS MDNENGLVCA EPACVLQMHT 190 200 210 PDIGGQGTTS EAIQDVIRHI RVINGRAVEA

References

[1]	"Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse." Brenner V., Nyakatura G., Rosenthal A., Platzer M. Genomics 44:8-14(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Soares liver spleen 1NFLS EMBL AAB70116.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U69269 mRNA. Translation: AAB70116.1.
IPI	IPI00382584.
UniGene	Hs.410197.
3D structure databases
HSSP	HSSP built from PDB template 1IPD based on UniProtKB P61495.
ProteinModelPortal	O15385.
ModBase	Search...
Protein-protein interaction databases
STRING	O15385.
Proteomic databases
PRIDE	O15385.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc004fiu.3. human.
Phylogenomic databases
HOGENOM	HOG000021113.
HOVERGEN	HBG052080.
Gene expression databases
ArrayExpress	O15385.
Bgee	O15385.
Family and domain databases
Gene3D	3.40.718.10. 1 hit.
InterPro	IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
PANTHER	PTHR11835. PTHR11835. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O15385_HUMAN

Accession

Primary (citable) accession number: O15385

Entry history

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.