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O15385

- O15385_HUMAN

UniProt

O15385 - O15385_HUMAN

Protein
Submitted name:

NAD (H)-specific isocitrate dehydrogenase gamma subunit

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    NAD (H)-specific isocitrate dehydrogenase gamma subunitImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: HPA
    2. nucleus Source: HPA

    PTM / Processingi

    Proteomic databases

    PRIDEiO15385.

    Expressioni

    Gene expression databases

    ArrayExpressiO15385.
    BgeeiO15385.

    Structurei

    3D structure databases

    ProteinModelPortaliO15385.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    HOVERGENiHBG052080.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    O15385-1 [UniParc]FASTAAdd to Basket

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    KSLRIAEYAF KLAQESGRKK VTAVHKANIM KLGDGLFLQC CREVAARYPQ    50
    ITFENMIVDN TTMQLVSRPQ QFDVMVMPNL YGNIVNNVCA GLVGGPGLVA 100
    GANYGHVYAV FETATRNTGK SIANKNIANP TATLLASCMM LDHLKLHSYA 150
    TSIRKAVLAS MDNENGLVCA EPACVLQMHT PDIGGQGTTS EAIQDVIRHI 200
    RVINGRAVEA 210
    Length:210
    Mass (Da):22,706
    Last modified:January 1, 1998 - v1
    Checksum:i2F83A837F5A59B1B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69269 mRNA. Translation: AAB70116.1.
    UniGeneiHs.410197.

    Genome annotation databases

    UCSCiuc004fiu.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69269 mRNA. Translation: AAB70116.1 .
    UniGenei Hs.410197.

    3D structure databases

    ProteinModelPortali O15385.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O15385.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc004fiu.3. human.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    HOVERGENi HBG052080.

    Gene expression databases

    ArrayExpressi O15385.
    Bgeei O15385.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse."
      Brenner V., Nyakatura G., Rosenthal A., Platzer M.
      Genomics 44:8-14(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Soares liver spleen 1NFLSImported.

    Entry informationi

    Entry nameiO15385_HUMAN
    AccessioniPrimary (citable) accession number: O15385
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 1, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.