O15381 (NVL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear valosin-containing protein-like
Short name=NVLp
Short name=Nuclear VCP-like protein

Gene names

Name:

NVL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	856 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with NCL/nucleolin. Ref.9
Subcellular location	Nucleus › nucleolus Ref.1 Ref.5.
Tissue specificity	Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina. Ref.1
Sequence similarities	Belongs to the AAA ATPase family.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	aggresome Inferred from direct assay. Source: HPA cytoplasm Inferred from direct assay. Source: HPA nucleolus Inferred from direct assay. Source: HPA
Molecular_function	ATP binding Traceable author statement Ref.1. Source: ProtInc nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O15381-1)

Also known as: NVLp.2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O15381-2)

Also known as: NVLp.1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Isoform 3 (identifier: O15381-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.
     115-205: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: O15381-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.
     320-320: G → GAECSGMITAHCSFDFSGSNDPPASASQ

Isoform 5 (identifier: O15381-5)

The sequence of this isoform differs from the canonical sequence as follows:
     115-205: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 856

856

Nuclear valosin-containing protein-like

PRO_0000084588

Regions

Nucleotide binding

305 – 312

8

ATP Potential

Nucleotide binding

622 – 629

8

ATP Probable

Motif

49 – 52

4

Nucleolar localization signal By similarity

Amino acid modifications

Modified residue

134

1

Phosphoserine Ref.6 Ref.7

Modified residue

138

1

Phosphothreonine Ref.6 Ref.7

Modified residue

211

1

Phosphoserine Ref.7 Ref.10

Modified residue

215

1

Phosphoserine Ref.7

Natural variations

Alternative sequence

1 – 216

216

Missing in isoform 4.

VSP_045334

Alternative sequence

1 – 106

106

Missing in isoform 2 and isoform 3.

VSP_007771

Alternative sequence

115 – 205

91

Missing in isoform 3 and isoform 5.

VSP_007772

Alternative sequence

320

1

G → GAECSGMITAHCSFDFSGSN DPPASASQ in isoform 4.

VSP_045335

Natural variant

295

1

V → I.
Corresponds to variant rs12084919 [ dbSNP | Ensembl ].

VAR_048109

Natural variant

359

1

C → G. Ref.1

VAR_015890

Natural variant

404

1

V → I.
Corresponds to variant rs34631151 [ dbSNP | Ensembl ].

VAR_048110

Secondary structure

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856

Helix Strand Turn

Details...

Helix

585 – 597

13

Helix

599 – 602

4

Helix

604 – 609

6

Beta strand

616 – 623

8

Helix

628 – 638

11

Beta strand

642 – 647

6

Turn

648 – 651

4

Helix

657 – 672

16

Beta strand

675 – 681

7

Turn

684 – 686

3

Helix

701 – 710

10

Beta strand

718 – 725

8

Helix

727 – 729

3

Helix

732 – 735

4

Beta strand

742 – 745

4

Helix

751 – 761

11

Turn

762 – 769

8

Helix

776 – 780

5

Helix

784 – 786

3

Helix

790 – 808

19

Helix

825 – 832

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (NVLp.2) [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 7A8B373FCAFB99B7	FASTA	856	95,051
	10 20 30 40 50 60 MKPRPAGFVD NKLKQRVIQY LTSNKCGKYV DIGVLASDLQ RVYSIDYGRR KRNAFRIQVE 70 80 90 100 110 120 KVFSIISSEK ELKNLTELED EHLAKRARQG EEDNEYTESY SDDDSSMEDY PDPQSANHMN 130 140 150 160 170 180 SSLLSLYRKG NPDSVSNTPE MEQRETTSST PRISSKTGSI PLKTPAKDSE GGWFIDKTPS 190 200 210 220 230 240 VKKDSFFLDL SCEKSNPKKP ITEIQDSKDS SLLESDMKRK GKLKNKGSKR KKEDLQEVDG 250 260 270 280 290 300 EIEAVLQKKA KARGLEFQIS NVKFEDVGGN DMTLKEVCKM LIHMRHPEVY HHLGVVPPRG 310 320 330 340 350 360 VLLHGPPGCG KTLLAHAIAG ELDLPILKVA APEIVSGVSG ESEQKLRELF EQAVSNAPCI 370 380 390 400 410 420 IFIDEIDAIT PKREVASKDM ERRIVAQLLT CMDDLNNVAA TARVLVIGAT NRPDSLDPAL 430 440 450 460 470 480 RRAGRFDREI CLGIPDEASR ERILQTLCRK LRLPQAFDFC HLAHLTPGFV GADLMALCRE 490 500 510 520 530 540 AAMCAVNRVL MKLQEQQKKN PEMEDLPSKG VQEERLGTEP TSETQDELQR LLGLLRDQDP 550 560 570 580 590 600 LSEEQMQGLC IELNDFIVAL SSVQPSAKRE GFVTVPNVTW ADIGALEDIR EELTMAILAP 610 620 630 640 650 660 VRNPDQFKAL GLVTPAGVLL AGPPGCGKTL LAKAVANESG LNFISVKGPE LLNMYVGESE 670 680 690 700 710 720 RAVRQVFQRA KNSAPCVIFF DEVDALCPRR SDRETGASVR VVNQLLTEMD GLEARQQVFI 730 740 750 760 770 780 MAATNRPDII DPAILRPGRL DKTLFVGLPP PADRLAILKT ITKNGTKPPL DADVNLEAIA 790 800 810 820 830 840 GDLRCDCYTG ADLSALVREA SICALRQEMA RQKSGNEKGE LKVSHKHFEE AFKKVRSSIS 850 KKDQIMYERL QESLSR
	Isoform 2 (NVLp.1) [UniParc]. Checksum: 56AF88DF9129D618	FASTA	750	82,746
	10 20 30 40 50 60 MEDYPDPQSA NHMNSSLLSL YRKGNPDSVS NTPEMEQRET TSSTPRISSK TGSIPLKTPA 70 80 90 100 110 120 KDSEGGWFID KTPSVKKDSF FLDLSCEKSN PKKPITEIQD SKDSSLLESD MKRKGKLKNK 130 140 150 160 170 180 GSKRKKEDLQ EVDGEIEAVL QKKAKARGLE FQISNVKFED VGGNDMTLKE VCKMLIHMRH 190 200 210 220 230 240 PEVYHHLGVV PPRGVLLHGP PGCGKTLLAH AIAGELDLPI LKVAAPEIVS GVSGESEQKL 250 260 270 280 290 300 RELFEQAVSN APCIIFIDEI DAITPKREVA SKDMERRIVA QLLTCMDDLN NVAATARVLV 310 320 330 340 350 360 IGATNRPDSL DPALRRAGRF DREICLGIPD EASRERILQT LCRKLRLPQA FDFCHLAHLT 370 380 390 400 410 420 PGFVGADLMA LCREAAMCAV NRVLMKLQEQ QKKNPEMEDL PSKGVQEERL GTEPTSETQD 430 440 450 460 470 480 ELQRLLGLLR DQDPLSEEQM QGLCIELNDF IVALSSVQPS AKREGFVTVP NVTWADIGAL 490 500 510 520 530 540 EDIREELTMA ILAPVRNPDQ FKALGLVTPA GVLLAGPPGC GKTLLAKAVA NESGLNFISV 550 560 570 580 590 600 KGPELLNMYV GESERAVRQV FQRAKNSAPC VIFFDEVDAL CPRRSDRETG ASVRVVNQLL 610 620 630 640 650 660 TEMDGLEARQ QVFIMAATNR PDIIDPAILR PGRLDKTLFV GLPPPADRLA ILKTITKNGT 670 680 690 700 710 720 KPPLDADVNL EAIAGDLRCD CYTGADLSAL VREASICALR QEMARQKSGN EKGELKVSHK 730 740 750 HFEEAFKKVR SSISKKDQIM YERLQESLSR
	Isoform 3 [UniParc]. Checksum: 0728D502901260F5	FASTA	659	72,733
	10 20 30 40 50 60 MEDYPDPQDS KDSSLLESDM KRKGKLKNKG SKRKKEDLQE VDGEIEAVLQ KKAKARGLEF 70 80 90 100 110 120 QISNVKFEDV GGNDMTLKEV CKMLIHMRHP EVYHHLGVVP PRGVLLHGPP GCGKTLLAHA 130 140 150 160 170 180 IAGELDLPIL KVAAPEIVSG VSGESEQKLR ELFEQAVSNA PCIIFIDEID AITPKREVAS 190 200 210 220 230 240 KDMERRIVAQ LLTCMDDLNN VAATARVLVI GATNRPDSLD PALRRAGRFD REICLGIPDE 250 260 270 280 290 300 ASRERILQTL CRKLRLPQAF DFCHLAHLTP GFVGADLMAL CREAAMCAVN RVLMKLQEQQ 310 320 330 340 350 360 KKNPEMEDLP SKGVQEERLG TEPTSETQDE LQRLLGLLRD QDPLSEEQMQ GLCIELNDFI 370 380 390 400 410 420 VALSSVQPSA KREGFVTVPN VTWADIGALE DIREELTMAI LAPVRNPDQF KALGLVTPAG 430 440 450 460 470 480 VLLAGPPGCG KTLLAKAVAN ESGLNFISVK GPELLNMYVG ESERAVRQVF QRAKNSAPCV 490 500 510 520 530 540 IFFDEVDALC PRRSDRETGA SVRVVNQLLT EMDGLEARQQ VFIMAATNRP DIIDPAILRP 550 560 570 580 590 600 GRLDKTLFVG LPPPADRLAI LKTITKNGTK PPLDADVNLE AIAGDLRCDC YTGADLSALV 610 620 630 640 650 REASICALRQ EMARQKSGNE KGELKVSHKH FEEAFKKVRS SISKKDQIMY ERLQESLSR
	Isoform 4 [UniParc]. Checksum: E46F119F9E1C345A	FASTA	667	73,280
	10 20 30 40 50 60 MKRKGKLKNK GSKRKKEDLQ EVDGEIEAVL QKKAKARGLE FQISNVKFED VGGNDMTLKE 70 80 90 100 110 120 VCKMLIHMRH PEVYHHLGVV PPRGVLLHGP PGCGKTLLAH AIAGAECSGM ITAHCSFDFS 130 140 150 160 170 180 GSNDPPASAS QELDLPILKV AAPEIVSGVS GESEQKLREL FEQAVSNAPC IIFIDEIDAI 190 200 210 220 230 240 TPKREVASKD MERRIVAQLL TCMDDLNNVA ATARVLVIGA TNRPDSLDPA LRRAGRFDRE 250 260 270 280 290 300 ICLGIPDEAS RERILQTLCR KLRLPQAFDF CHLAHLTPGF VGADLMALCR EAAMCAVNRV 310 320 330 340 350 360 LMKLQEQQKK NPEMEDLPSK GVQEERLGTE PTSETQDELQ RLLGLLRDQD PLSEEQMQGL 370 380 390 400 410 420 CIELNDFIVA LSSVQPSAKR EGFVTVPNVT WADIGALEDI REELTMAILA PVRNPDQFKA 430 440 450 460 470 480 LGLVTPAGVL LAGPPGCGKT LLAKAVANES GLNFISVKGP ELLNMYVGES ERAVRQVFQR 490 500 510 520 530 540 AKNSAPCVIF FDEVDALCPR RSDRETGASV RVVNQLLTEM DGLEARQQVF IMAATNRPDI 550 560 570 580 590 600 IDPAILRPGR LDKTLFVGLP PPADRLAILK TITKNGTKPP LDADVNLEAI AGDLRCDCYT 610 620 630 640 650 660 GADLSALVRE ASICALRQEM ARQKSGNEKG ELKVSHKHFE EAFKKVRSSI SKKDQIMYER LQESLSR
	Isoform 5 [UniParc]. Checksum: A34DEE65ED8A82D6	FASTA	765	85,038
	10 20 30 40 50 60 MKPRPAGFVD NKLKQRVIQY LTSNKCGKYV DIGVLASDLQ RVYSIDYGRR KRNAFRIQVE 70 80 90 100 110 120 KVFSIISSEK ELKNLTELED EHLAKRARQG EEDNEYTESY SDDDSSMEDY PDPQDSKDSS 130 140 150 160 170 180 LLESDMKRKG KLKNKGSKRK KEDLQEVDGE IEAVLQKKAK ARGLEFQISN VKFEDVGGND 190 200 210 220 230 240 MTLKEVCKML IHMRHPEVYH HLGVVPPRGV LLHGPPGCGK TLLAHAIAGE LDLPILKVAA 250 260 270 280 290 300 PEIVSGVSGE SEQKLRELFE QAVSNAPCII FIDEIDAITP KREVASKDME RRIVAQLLTC 310 320 330 340 350 360 MDDLNNVAAT ARVLVIGATN RPDSLDPALR RAGRFDREIC LGIPDEASRE RILQTLCRKL 370 380 390 400 410 420 RLPQAFDFCH LAHLTPGFVG ADLMALCREA AMCAVNRVLM KLQEQQKKNP EMEDLPSKGV 430 440 450 460 470 480 QEERLGTEPT SETQDELQRL LGLLRDQDPL SEEQMQGLCI ELNDFIVALS SVQPSAKREG 490 500 510 520 530 540 FVTVPNVTWA DIGALEDIRE ELTMAILAPV RNPDQFKALG LVTPAGVLLA GPPGCGKTLL 550 560 570 580 590 600 AKAVANESGL NFISVKGPEL LNMYVGESER AVRQVFQRAK NSAPCVIFFD EVDALCPRRS 610 620 630 640 650 660 DRETGASVRV VNQLLTEMDG LEARQQVFIM AATNRPDIID PAILRPGRLD KTLFVGLPPP 670 680 690 700 710 720 ADRLAILKTI TKNGTKPPLD ADVNLEAIAG DLRCDCYTGA DLSALVREAS ICALRQEMAR 730 740 750 760 QKSGNEKGEL KVSHKHFEEA FKKVRSSISK KDQIMYERLQ ESLSR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"NVL: a new member of the AAA family of ATPases localized to the nucleus." Germain-Lee E.L., Obie C., Valle D. Genomics 44:22-34(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT GLY-359, PHOSPHORYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Kidney.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5). Tissue: Brain.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Eye.
[5]	"Functional proteomic analysis of human nucleolus." Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134 AND THR-138, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134; THR-138; SER-211 AND SER-215, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal." Fujiwara Y., Fujiwara K., Goda N., Iwaya N., Tenno T., Shirakawa M., Hiroaki H. J. Biol. Chem. 286:21732-21741(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NCL/NUCLEOLIN.
[10]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, MASS SPECTROMETRY.
[11]	"Human nuclear valosin containing protein like (NVL), C-terminal AAA-ATPase domain." Structural genomics consortium (SGC) Submitted (MAR-2010) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 574-845 IN COMPLEX WITH PHOSPHATE.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U68140 mRNA. Translation: AAB70457.1.
U78772 mRNA. Translation: AAB70460.1.
AK297396 mRNA. Translation: BAG59836.1.
AK298244 mRNA. Translation: BAG60510.1.
AC092809 Genomic DNA. No translation available.
BC012105 mRNA. Translation: AAH12105.1.

IPI

IPI00006197.
IPI00183080.
IPI00185801.

RefSeq

NP_001230075.1. NM_001243146.1.
NP_001230076.1. NM_001243147.1.
NP_002524.2. NM_002533.3.
NP_996671.1. NM_206840.2.

UniGene

Hs.497867.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2X8A	X-ray	2.60	A	574-845	[»]

ProteinModelPortal

O15381.

ModBase

Search...

Protein-protein interaction databases

IntAct

O15381. 1 interaction.

MINT

MINT-1423251.

STRING

9606.ENSP00000281701.

PTM databases

PhosphoSite

O15381.

2D gel databases

SWISS-2DPAGE

O15381.

Proteomic databases

PaxDb

O15381.

PRIDE

O15381.

Protocols and materials databases

DNASU

4931.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000281701; ENSP00000281701; ENSG00000143748.
ENST00000340871; ENSP00000341362; ENSG00000143748.
ENST00000391875; ENSP00000375747; ENSG00000143748.
ENST00000469075; ENSP00000417826; ENSG00000143748.

GeneID

4931.

KEGG

hsa:4931.

UCSC

uc001hok.3. human.

Organism-specific databases

CTD

4931.

GeneCards

GC01M224416.

HGNC

HGNC:8070. NVL.

HPA

HPA028207.

MIM

602426. gene.

neXtProt

NX_O15381.

PharmGKB

PA31857.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0464.

HOGENOM

HOG000223225.

HOVERGEN

HBG001226.

InParanoid

O15381.

KO

K14571.

OMA

NDMTLKE.

OrthoDB

EOG4ZPDTN.

PhylomeDB

O15381.

Gene expression databases

ArrayExpress

O15381.

Bgee

O15381.

CleanEx

HS_NVL.

Genevestigator

O15381.

GermOnline

ENSG00000143748. Homo sapiens.

Family and domain databases

InterPro

IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
[Graphical view]

Pfam

PF00004. AAA. 2 hits.
[Graphical view]

SMART

SM00382. AAA. 2 hits.
[Graphical view]

PROSITE

PS00674. AAA. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

NVL. human.

EvolutionaryTrace

O15381.

GenomeRNAi

4931.

NextBio

19001.

SOURCE

Search...

Entry information

Entry name

NVL_HUMAN

Accession

Primary (citable) accession number: O15381
Secondary accession number(s): B4DMC4, B4DP98, Q96EM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.