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O15381

- NVL_HUMAN

UniProt

O15381 - NVL_HUMAN

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Protein

Nuclear valosin-containing protein-like

Gene

NVL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi305 – 3128ATPSequence Analysis
Nucleotide bindingi622 – 6298ATPCurated

GO - Molecular functioni

  1. ATP binding Source: ProtInc
  2. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear valosin-containing protein-like
Short name:
NVLp
Short name:
Nuclear VCP-like protein
Gene namesi
Name:NVL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:8070. NVL.

Subcellular locationi

Nucleusnucleolus 2 Publications

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31857.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 856856Nuclear valosin-containing protein-likePRO_0000084588Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701N6-acetyllysineBy similarity
Modified residuei134 – 1341Phosphoserine2 Publications
Modified residuei138 – 1381Phosphothreonine2 Publications
Modified residuei156 – 1561N6-acetyllysineBy similarity
Modified residuei191 – 1911PhosphoserineBy similarity
Modified residuei211 – 2111Phosphoserine2 Publications
Modified residuei215 – 2151Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO15381.
PaxDbiO15381.
PRIDEiO15381.

2D gel databases

SWISS-2DPAGEO15381.

PTM databases

PhosphoSiteiO15381.

Expressioni

Tissue specificityi

Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.1 Publication

Gene expression databases

BgeeiO15381.
CleanExiHS_NVL.
ExpressionAtlasiO15381. baseline and differential.
GenevestigatoriO15381.

Organism-specific databases

HPAiHPA028207.

Interactioni

Subunit structurei

Interacts with NCL/nucleolin.2 Publications

Protein-protein interaction databases

BioGridi110985. 11 interactions.
IntActiO15381. 4 interactions.
MINTiMINT-1423251.
STRINGi9606.ENSP00000281701.

Structurei

Secondary structure

1
856
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi585 – 59713Combined sources
Helixi599 – 6024Combined sources
Helixi604 – 6096Combined sources
Beta strandi616 – 6238Combined sources
Helixi628 – 63811Combined sources
Beta strandi642 – 6476Combined sources
Turni648 – 6514Combined sources
Helixi657 – 67216Combined sources
Beta strandi675 – 6817Combined sources
Turni684 – 6863Combined sources
Helixi701 – 71010Combined sources
Beta strandi718 – 7258Combined sources
Helixi727 – 7293Combined sources
Helixi732 – 7354Combined sources
Beta strandi742 – 7454Combined sources
Helixi751 – 76111Combined sources
Turni762 – 7698Combined sources
Helixi776 – 7805Combined sources
Helixi784 – 7863Combined sources
Helixi790 – 80819Combined sources
Helixi825 – 8328Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X8AX-ray2.60A574-845[»]
ProteinModelPortaliO15381.
SMRiO15381. Positions 1-74, 256-854.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15381.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 524Nucleolar localization signalBy similarity

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0464.
GeneTreeiENSGT00570000079239.
HOGENOMiHOG000223225.
HOVERGENiHBG001226.
InParanoidiO15381.
KOiK14571.
OMAiELHMCIV.
PhylomeDBiO15381.
TreeFamiTF314681.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O15381-1) [UniParc]FASTAAdd to Basket

Also known as: NVLp.2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPRPAGFVD NKLKQRVIQY LTSNKCGKYV DIGVLASDLQ RVYSIDYGRR
60 70 80 90 100
KRNAFRIQVE KVFSIISSEK ELKNLTELED EHLAKRARQG EEDNEYTESY
110 120 130 140 150
SDDDSSMEDY PDPQSANHMN SSLLSLYRKG NPDSVSNTPE MEQRETTSST
160 170 180 190 200
PRISSKTGSI PLKTPAKDSE GGWFIDKTPS VKKDSFFLDL SCEKSNPKKP
210 220 230 240 250
ITEIQDSKDS SLLESDMKRK GKLKNKGSKR KKEDLQEVDG EIEAVLQKKA
260 270 280 290 300
KARGLEFQIS NVKFEDVGGN DMTLKEVCKM LIHMRHPEVY HHLGVVPPRG
310 320 330 340 350
VLLHGPPGCG KTLLAHAIAG ELDLPILKVA APEIVSGVSG ESEQKLRELF
360 370 380 390 400
EQAVSNAPCI IFIDEIDAIT PKREVASKDM ERRIVAQLLT CMDDLNNVAA
410 420 430 440 450
TARVLVIGAT NRPDSLDPAL RRAGRFDREI CLGIPDEASR ERILQTLCRK
460 470 480 490 500
LRLPQAFDFC HLAHLTPGFV GADLMALCRE AAMCAVNRVL MKLQEQQKKN
510 520 530 540 550
PEMEDLPSKG VQEERLGTEP TSETQDELQR LLGLLRDQDP LSEEQMQGLC
560 570 580 590 600
IELNDFIVAL SSVQPSAKRE GFVTVPNVTW ADIGALEDIR EELTMAILAP
610 620 630 640 650
VRNPDQFKAL GLVTPAGVLL AGPPGCGKTL LAKAVANESG LNFISVKGPE
660 670 680 690 700
LLNMYVGESE RAVRQVFQRA KNSAPCVIFF DEVDALCPRR SDRETGASVR
710 720 730 740 750
VVNQLLTEMD GLEARQQVFI MAATNRPDII DPAILRPGRL DKTLFVGLPP
760 770 780 790 800
PADRLAILKT ITKNGTKPPL DADVNLEAIA GDLRCDCYTG ADLSALVREA
810 820 830 840 850
SICALRQEMA RQKSGNEKGE LKVSHKHFEE AFKKVRSSIS KKDQIMYERL

QESLSR
Length:856
Mass (Da):95,051
Last modified:January 1, 1998 - v1
Checksum:i7A8B373FCAFB99B7
GO
Isoform 2 (identifier: O15381-2) [UniParc]FASTAAdd to Basket

Also known as: NVLp.1

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:750
Mass (Da):82,746
Checksum:i56AF88DF9129D618
GO
Isoform 3 (identifier: O15381-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.
     115-205: Missing.

Note: No experimental confirmation available.

Show »
Length:659
Mass (Da):72,733
Checksum:i0728D502901260F5
GO
Isoform 4 (identifier: O15381-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.
     320-320: G → GAECSGMITAHCSFDFSGSNDPPASASQ

Show »
Length:667
Mass (Da):73,280
Checksum:iE46F119F9E1C345A
GO
Isoform 5 (identifier: O15381-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-205: Missing.

Show »
Length:765
Mass (Da):85,038
Checksum:iA34DEE65ED8A82D6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti295 – 2951V → I.
Corresponds to variant rs12084919 [ dbSNP | Ensembl ].
VAR_048109
Natural varianti359 – 3591C → G.1 Publication
VAR_015890
Natural varianti404 – 4041V → I.
Corresponds to variant rs34631151 [ dbSNP | Ensembl ].
VAR_048110

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 216216Missing in isoform 4. 1 PublicationVSP_045334Add
BLAST
Alternative sequencei1 – 106106Missing in isoform 2 and isoform 3. 2 PublicationsVSP_007771Add
BLAST
Alternative sequencei115 – 20591Missing in isoform 3 and isoform 5. 2 PublicationsVSP_007772Add
BLAST
Alternative sequencei320 – 3201G → GAECSGMITAHCSFDFSGSN DPPASASQ in isoform 4. 1 PublicationVSP_045335

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U68140 mRNA. Translation: AAB70457.1.
U78772 mRNA. Translation: AAB70460.1.
AK297396 mRNA. Translation: BAG59836.1.
AK298244 mRNA. Translation: BAG60510.1.
AC092809 Genomic DNA. No translation available.
BC012105 mRNA. Translation: AAH12105.1.
CCDSiCCDS1541.1. [O15381-1]
CCDS1542.1. [O15381-2]
CCDS58062.1. [O15381-4]
CCDS58063.1. [O15381-5]
RefSeqiNP_001230075.1. NM_001243146.1. [O15381-4]
NP_001230076.1. NM_001243147.1. [O15381-5]
NP_002524.2. NM_002533.3. [O15381-1]
NP_996671.1. NM_206840.2. [O15381-2]
UniGeneiHs.497867.

Genome annotation databases

EnsembliENST00000281701; ENSP00000281701; ENSG00000143748. [O15381-1]
ENST00000340871; ENSP00000341362; ENSG00000143748. [O15381-4]
ENST00000391875; ENSP00000375747; ENSG00000143748. [O15381-2]
ENST00000469075; ENSP00000417826; ENSG00000143748. [O15381-5]
ENST00000469968; ENSP00000419420; ENSG00000143748. [O15381-3]
ENST00000482491; ENSP00000417213; ENSG00000143748. [O15381-4]
GeneIDi4931.
KEGGihsa:4931.
UCSCiuc001hok.3. human. [O15381-1]
uc010pvd.2. human.
uc010pve.2. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U68140 mRNA. Translation: AAB70457.1 .
U78772 mRNA. Translation: AAB70460.1 .
AK297396 mRNA. Translation: BAG59836.1 .
AK298244 mRNA. Translation: BAG60510.1 .
AC092809 Genomic DNA. No translation available.
BC012105 mRNA. Translation: AAH12105.1 .
CCDSi CCDS1541.1. [O15381-1 ]
CCDS1542.1. [O15381-2 ]
CCDS58062.1. [O15381-4 ]
CCDS58063.1. [O15381-5 ]
RefSeqi NP_001230075.1. NM_001243146.1. [O15381-4 ]
NP_001230076.1. NM_001243147.1. [O15381-5 ]
NP_002524.2. NM_002533.3. [O15381-1 ]
NP_996671.1. NM_206840.2. [O15381-2 ]
UniGenei Hs.497867.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2X8A X-ray 2.60 A 574-845 [» ]
ProteinModelPortali O15381.
SMRi O15381. Positions 1-74, 256-854.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110985. 11 interactions.
IntActi O15381. 4 interactions.
MINTi MINT-1423251.
STRINGi 9606.ENSP00000281701.

PTM databases

PhosphoSitei O15381.

2D gel databases

SWISS-2DPAGE O15381.

Proteomic databases

MaxQBi O15381.
PaxDbi O15381.
PRIDEi O15381.

Protocols and materials databases

DNASUi 4931.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281701 ; ENSP00000281701 ; ENSG00000143748 . [O15381-1 ]
ENST00000340871 ; ENSP00000341362 ; ENSG00000143748 . [O15381-4 ]
ENST00000391875 ; ENSP00000375747 ; ENSG00000143748 . [O15381-2 ]
ENST00000469075 ; ENSP00000417826 ; ENSG00000143748 . [O15381-5 ]
ENST00000469968 ; ENSP00000419420 ; ENSG00000143748 . [O15381-3 ]
ENST00000482491 ; ENSP00000417213 ; ENSG00000143748 . [O15381-4 ]
GeneIDi 4931.
KEGGi hsa:4931.
UCSCi uc001hok.3. human. [O15381-1 ]
uc010pvd.2. human.
uc010pve.2. human.

Organism-specific databases

CTDi 4931.
GeneCardsi GC01M224416.
HGNCi HGNC:8070. NVL.
HPAi HPA028207.
MIMi 602426. gene.
neXtProti NX_O15381.
PharmGKBi PA31857.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0464.
GeneTreei ENSGT00570000079239.
HOGENOMi HOG000223225.
HOVERGENi HBG001226.
InParanoidi O15381.
KOi K14571.
OMAi ELHMCIV.
PhylomeDBi O15381.
TreeFami TF314681.

Miscellaneous databases

ChiTaRSi NVL. human.
EvolutionaryTracei O15381.
GeneWikii NVL_(gene).
GenomeRNAii 4931.
NextBioi 19001.
PROi O15381.
SOURCEi Search...

Gene expression databases

Bgeei O15381.
CleanExi HS_NVL.
ExpressionAtlasi O15381. baseline and differential.
Genevestigatori O15381.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00674. AAA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NVL: a new member of the AAA family of ATPases localized to the nucleus."
    Germain-Lee E.L., Obie C., Valle D.
    Genomics 44:22-34(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT GLY-359, PHOSPHORYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
    Tissue: Brain.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Eye.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134 AND THR-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134; THR-138; SER-211 AND SER-215, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal."
    Fujiwara Y., Fujiwara K., Goda N., Iwaya N., Tenno T., Shirakawa M., Hiroaki H.
    J. Biol. Chem. 286:21732-21741(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NCL/NUCLEOLIN.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Human nuclear valosin containing protein like (NVL), C-terminal AAA-ATPase domain."
    Structural genomics consortium (SGC)
    Submitted (MAR-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 574-845 IN COMPLEX WITH PHOSPHATE.

Entry informationi

Entry nameiNVL_HUMAN
AccessioniPrimary (citable) accession number: O15381
Secondary accession number(s): B4DMC4, B4DP98, Q96EM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3