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O15381

- NVL_HUMAN

UniProt

O15381 - NVL_HUMAN

Protein

Nuclear valosin-containing protein-like

Gene

NVL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi305 – 3128ATPSequence Analysis
    Nucleotide bindingi622 – 6298ATPCurated

    GO - Molecular functioni

    1. ATP binding Source: ProtInc
    2. nucleoside-triphosphatase activity Source: InterPro
    3. poly(A) RNA binding Source: UniProtKB

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear valosin-containing protein-like
    Short name:
    NVLp
    Short name:
    Nuclear VCP-like protein
    Gene namesi
    Name:NVL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8070. NVL.

    Subcellular locationi

    Nucleusnucleolus 2 Publications

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. nucleolus Source: UniProtKB-SubCell
    3. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31857.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 856856Nuclear valosin-containing protein-likePRO_0000084588Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei70 – 701N6-acetyllysineBy similarity
    Modified residuei134 – 1341Phosphoserine3 Publications
    Modified residuei138 – 1381Phosphothreonine3 Publications
    Modified residuei156 – 1561N6-acetyllysineBy similarity
    Modified residuei191 – 1911PhosphoserineBy similarity
    Modified residuei211 – 2111Phosphoserine3 Publications
    Modified residuei215 – 2151Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO15381.
    PaxDbiO15381.
    PRIDEiO15381.

    2D gel databases

    SWISS-2DPAGEO15381.

    PTM databases

    PhosphoSiteiO15381.

    Expressioni

    Tissue specificityi

    Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.1 Publication

    Gene expression databases

    ArrayExpressiO15381.
    BgeeiO15381.
    CleanExiHS_NVL.
    GenevestigatoriO15381.

    Organism-specific databases

    HPAiHPA028207.

    Interactioni

    Subunit structurei

    Interacts with NCL/nucleolin.2 Publications

    Protein-protein interaction databases

    BioGridi110985. 7 interactions.
    IntActiO15381. 4 interactions.
    MINTiMINT-1423251.
    STRINGi9606.ENSP00000281701.

    Structurei

    Secondary structure

    1
    856
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi585 – 59713
    Helixi599 – 6024
    Helixi604 – 6096
    Beta strandi616 – 6238
    Helixi628 – 63811
    Beta strandi642 – 6476
    Turni648 – 6514
    Helixi657 – 67216
    Beta strandi675 – 6817
    Turni684 – 6863
    Helixi701 – 71010
    Beta strandi718 – 7258
    Helixi727 – 7293
    Helixi732 – 7354
    Beta strandi742 – 7454
    Helixi751 – 76111
    Turni762 – 7698
    Helixi776 – 7805
    Helixi784 – 7863
    Helixi790 – 80819
    Helixi825 – 8328

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2X8AX-ray2.60A574-845[»]
    ProteinModelPortaliO15381.
    SMRiO15381. Positions 1-74, 256-854.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO15381.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi49 – 524Nucleolar localization signalBy similarity

    Sequence similaritiesi

    Belongs to the AAA ATPase family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0464.
    HOGENOMiHOG000223225.
    HOVERGENiHBG001226.
    InParanoidiO15381.
    KOiK14571.
    OMAiELHMCIV.
    PhylomeDBiO15381.
    TreeFamiTF314681.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00674. AAA. 2 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O15381-1) [UniParc]FASTAAdd to Basket

    Also known as: NVLp.2

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKPRPAGFVD NKLKQRVIQY LTSNKCGKYV DIGVLASDLQ RVYSIDYGRR    50
    KRNAFRIQVE KVFSIISSEK ELKNLTELED EHLAKRARQG EEDNEYTESY 100
    SDDDSSMEDY PDPQSANHMN SSLLSLYRKG NPDSVSNTPE MEQRETTSST 150
    PRISSKTGSI PLKTPAKDSE GGWFIDKTPS VKKDSFFLDL SCEKSNPKKP 200
    ITEIQDSKDS SLLESDMKRK GKLKNKGSKR KKEDLQEVDG EIEAVLQKKA 250
    KARGLEFQIS NVKFEDVGGN DMTLKEVCKM LIHMRHPEVY HHLGVVPPRG 300
    VLLHGPPGCG KTLLAHAIAG ELDLPILKVA APEIVSGVSG ESEQKLRELF 350
    EQAVSNAPCI IFIDEIDAIT PKREVASKDM ERRIVAQLLT CMDDLNNVAA 400
    TARVLVIGAT NRPDSLDPAL RRAGRFDREI CLGIPDEASR ERILQTLCRK 450
    LRLPQAFDFC HLAHLTPGFV GADLMALCRE AAMCAVNRVL MKLQEQQKKN 500
    PEMEDLPSKG VQEERLGTEP TSETQDELQR LLGLLRDQDP LSEEQMQGLC 550
    IELNDFIVAL SSVQPSAKRE GFVTVPNVTW ADIGALEDIR EELTMAILAP 600
    VRNPDQFKAL GLVTPAGVLL AGPPGCGKTL LAKAVANESG LNFISVKGPE 650
    LLNMYVGESE RAVRQVFQRA KNSAPCVIFF DEVDALCPRR SDRETGASVR 700
    VVNQLLTEMD GLEARQQVFI MAATNRPDII DPAILRPGRL DKTLFVGLPP 750
    PADRLAILKT ITKNGTKPPL DADVNLEAIA GDLRCDCYTG ADLSALVREA 800
    SICALRQEMA RQKSGNEKGE LKVSHKHFEE AFKKVRSSIS KKDQIMYERL 850
    QESLSR 856
    Length:856
    Mass (Da):95,051
    Last modified:January 1, 1998 - v1
    Checksum:i7A8B373FCAFB99B7
    GO
    Isoform 2 (identifier: O15381-2) [UniParc]FASTAAdd to Basket

    Also known as: NVLp.1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-106: Missing.

    Show »
    Length:750
    Mass (Da):82,746
    Checksum:i56AF88DF9129D618
    GO
    Isoform 3 (identifier: O15381-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-106: Missing.
         115-205: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:659
    Mass (Da):72,733
    Checksum:i0728D502901260F5
    GO
    Isoform 4 (identifier: O15381-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-216: Missing.
         320-320: G → GAECSGMITAHCSFDFSGSNDPPASASQ

    Show »
    Length:667
    Mass (Da):73,280
    Checksum:iE46F119F9E1C345A
    GO
    Isoform 5 (identifier: O15381-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         115-205: Missing.

    Show »
    Length:765
    Mass (Da):85,038
    Checksum:iA34DEE65ED8A82D6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti295 – 2951V → I.
    Corresponds to variant rs12084919 [ dbSNP | Ensembl ].
    VAR_048109
    Natural varianti359 – 3591C → G.1 Publication
    VAR_015890
    Natural varianti404 – 4041V → I.
    Corresponds to variant rs34631151 [ dbSNP | Ensembl ].
    VAR_048110

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 216216Missing in isoform 4. 1 PublicationVSP_045334Add
    BLAST
    Alternative sequencei1 – 106106Missing in isoform 2 and isoform 3. 2 PublicationsVSP_007771Add
    BLAST
    Alternative sequencei115 – 20591Missing in isoform 3 and isoform 5. 2 PublicationsVSP_007772Add
    BLAST
    Alternative sequencei320 – 3201G → GAECSGMITAHCSFDFSGSN DPPASASQ in isoform 4. 1 PublicationVSP_045335

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U68140 mRNA. Translation: AAB70457.1.
    U78772 mRNA. Translation: AAB70460.1.
    AK297396 mRNA. Translation: BAG59836.1.
    AK298244 mRNA. Translation: BAG60510.1.
    AC092809 Genomic DNA. No translation available.
    BC012105 mRNA. Translation: AAH12105.1.
    CCDSiCCDS1541.1. [O15381-1]
    CCDS1542.1. [O15381-2]
    CCDS58062.1. [O15381-4]
    CCDS58063.1. [O15381-5]
    RefSeqiNP_001230075.1. NM_001243146.1. [O15381-4]
    NP_001230076.1. NM_001243147.1. [O15381-5]
    NP_002524.2. NM_002533.3. [O15381-1]
    NP_996671.1. NM_206840.2. [O15381-2]
    UniGeneiHs.497867.

    Genome annotation databases

    EnsembliENST00000281701; ENSP00000281701; ENSG00000143748. [O15381-1]
    ENST00000340871; ENSP00000341362; ENSG00000143748. [O15381-4]
    ENST00000391875; ENSP00000375747; ENSG00000143748. [O15381-2]
    ENST00000469075; ENSP00000417826; ENSG00000143748. [O15381-5]
    GeneIDi4931.
    KEGGihsa:4931.
    UCSCiuc001hok.3. human. [O15381-1]
    uc010pvd.2. human.
    uc010pve.2. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U68140 mRNA. Translation: AAB70457.1 .
    U78772 mRNA. Translation: AAB70460.1 .
    AK297396 mRNA. Translation: BAG59836.1 .
    AK298244 mRNA. Translation: BAG60510.1 .
    AC092809 Genomic DNA. No translation available.
    BC012105 mRNA. Translation: AAH12105.1 .
    CCDSi CCDS1541.1. [O15381-1 ]
    CCDS1542.1. [O15381-2 ]
    CCDS58062.1. [O15381-4 ]
    CCDS58063.1. [O15381-5 ]
    RefSeqi NP_001230075.1. NM_001243146.1. [O15381-4 ]
    NP_001230076.1. NM_001243147.1. [O15381-5 ]
    NP_002524.2. NM_002533.3. [O15381-1 ]
    NP_996671.1. NM_206840.2. [O15381-2 ]
    UniGenei Hs.497867.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2X8A X-ray 2.60 A 574-845 [» ]
    ProteinModelPortali O15381.
    SMRi O15381. Positions 1-74, 256-854.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110985. 7 interactions.
    IntActi O15381. 4 interactions.
    MINTi MINT-1423251.
    STRINGi 9606.ENSP00000281701.

    PTM databases

    PhosphoSitei O15381.

    2D gel databases

    SWISS-2DPAGE O15381.

    Proteomic databases

    MaxQBi O15381.
    PaxDbi O15381.
    PRIDEi O15381.

    Protocols and materials databases

    DNASUi 4931.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281701 ; ENSP00000281701 ; ENSG00000143748 . [O15381-1 ]
    ENST00000340871 ; ENSP00000341362 ; ENSG00000143748 . [O15381-4 ]
    ENST00000391875 ; ENSP00000375747 ; ENSG00000143748 . [O15381-2 ]
    ENST00000469075 ; ENSP00000417826 ; ENSG00000143748 . [O15381-5 ]
    GeneIDi 4931.
    KEGGi hsa:4931.
    UCSCi uc001hok.3. human. [O15381-1 ]
    uc010pvd.2. human.
    uc010pve.2. human.

    Organism-specific databases

    CTDi 4931.
    GeneCardsi GC01M224416.
    HGNCi HGNC:8070. NVL.
    HPAi HPA028207.
    MIMi 602426. gene.
    neXtProti NX_O15381.
    PharmGKBi PA31857.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0464.
    HOGENOMi HOG000223225.
    HOVERGENi HBG001226.
    InParanoidi O15381.
    KOi K14571.
    OMAi ELHMCIV.
    PhylomeDBi O15381.
    TreeFami TF314681.

    Miscellaneous databases

    ChiTaRSi NVL. human.
    EvolutionaryTracei O15381.
    GeneWikii NVL_(gene).
    GenomeRNAii 4931.
    NextBioi 19001.
    PROi O15381.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15381.
    Bgeei O15381.
    CleanExi HS_NVL.
    Genevestigatori O15381.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00674. AAA. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NVL: a new member of the AAA family of ATPases localized to the nucleus."
      Germain-Lee E.L., Obie C., Valle D.
      Genomics 44:22-34(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT GLY-359, PHOSPHORYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Kidney.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
      Tissue: Brain.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Eye.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134 AND THR-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134; THR-138; SER-211 AND SER-215, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal."
      Fujiwara Y., Fujiwara K., Goda N., Iwaya N., Tenno T., Shirakawa M., Hiroaki H.
      J. Biol. Chem. 286:21732-21741(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NCL/NUCLEOLIN.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Human nuclear valosin containing protein like (NVL), C-terminal AAA-ATPase domain."
      Structural genomics consortium (SGC)
      Submitted (MAR-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 574-845 IN COMPLEX WITH PHOSPHATE.

    Entry informationi

    Entry nameiNVL_HUMAN
    AccessioniPrimary (citable) accession number: O15381
    Secondary accession number(s): B4DMC4, B4DP98, Q96EM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3