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O15381

- NVL_HUMAN

UniProt

O15381 - NVL_HUMAN

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Protein
Nuclear valosin-containing protein-like
Gene
NVL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi305 – 3128ATP Reviewed prediction
Nucleotide bindingi622 – 6298ATP Inferred

GO - Molecular functioni

  1. ATP binding Source: ProtInc
  2. nucleoside-triphosphatase activity Source: InterPro
  3. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear valosin-containing protein-like
Short name:
NVLp
Short name:
Nuclear VCP-like protein
Gene namesi
Name:NVL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:8070. NVL.

Subcellular locationi

Nucleusnucleolus 2 Publications

GO - Cellular componenti

  1. nucleolus Source: UniProtKB-SubCell
  2. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31857.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 856856Nuclear valosin-containing protein-like
PRO_0000084588Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701N6-acetyllysine By similarity
Modified residuei134 – 1341Phosphoserine2 Publications
Modified residuei138 – 1381Phosphothreonine2 Publications
Modified residuei156 – 1561N6-acetyllysine By similarity
Modified residuei191 – 1911Phosphoserine By similarity
Modified residuei211 – 2111Phosphoserine2 Publications
Modified residuei215 – 2151Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO15381.
PaxDbiO15381.
PRIDEiO15381.

2D gel databases

SWISS-2DPAGEO15381.

PTM databases

PhosphoSiteiO15381.

Expressioni

Tissue specificityi

Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.1 Publication

Gene expression databases

ArrayExpressiO15381.
BgeeiO15381.
CleanExiHS_NVL.
GenevestigatoriO15381.

Organism-specific databases

HPAiHPA028207.

Interactioni

Subunit structurei

Interacts with NCL/nucleolin.1 Publication

Protein-protein interaction databases

BioGridi110985. 7 interactions.
IntActiO15381. 4 interactions.
MINTiMINT-1423251.
STRINGi9606.ENSP00000281701.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi585 – 59713
Helixi599 – 6024
Helixi604 – 6096
Beta strandi616 – 6238
Helixi628 – 63811
Beta strandi642 – 6476
Turni648 – 6514
Helixi657 – 67216
Beta strandi675 – 6817
Turni684 – 6863
Helixi701 – 71010
Beta strandi718 – 7258
Helixi727 – 7293
Helixi732 – 7354
Beta strandi742 – 7454
Helixi751 – 76111
Turni762 – 7698
Helixi776 – 7805
Helixi784 – 7863
Helixi790 – 80819
Helixi825 – 8328

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X8AX-ray2.60A574-845[»]
ProteinModelPortaliO15381.
SMRiO15381. Positions 1-74, 256-854.

Miscellaneous databases

EvolutionaryTraceiO15381.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 524Nucleolar localization signal By similarity

Sequence similaritiesi

Belongs to the AAA ATPase family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0464.
HOGENOMiHOG000223225.
HOVERGENiHBG001226.
InParanoidiO15381.
KOiK14571.
OMAiELHMCIV.
PhylomeDBiO15381.
TreeFamiTF314681.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O15381-1) [UniParc]FASTAAdd to Basket

Also known as: NVLp.2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKPRPAGFVD NKLKQRVIQY LTSNKCGKYV DIGVLASDLQ RVYSIDYGRR    50
KRNAFRIQVE KVFSIISSEK ELKNLTELED EHLAKRARQG EEDNEYTESY 100
SDDDSSMEDY PDPQSANHMN SSLLSLYRKG NPDSVSNTPE MEQRETTSST 150
PRISSKTGSI PLKTPAKDSE GGWFIDKTPS VKKDSFFLDL SCEKSNPKKP 200
ITEIQDSKDS SLLESDMKRK GKLKNKGSKR KKEDLQEVDG EIEAVLQKKA 250
KARGLEFQIS NVKFEDVGGN DMTLKEVCKM LIHMRHPEVY HHLGVVPPRG 300
VLLHGPPGCG KTLLAHAIAG ELDLPILKVA APEIVSGVSG ESEQKLRELF 350
EQAVSNAPCI IFIDEIDAIT PKREVASKDM ERRIVAQLLT CMDDLNNVAA 400
TARVLVIGAT NRPDSLDPAL RRAGRFDREI CLGIPDEASR ERILQTLCRK 450
LRLPQAFDFC HLAHLTPGFV GADLMALCRE AAMCAVNRVL MKLQEQQKKN 500
PEMEDLPSKG VQEERLGTEP TSETQDELQR LLGLLRDQDP LSEEQMQGLC 550
IELNDFIVAL SSVQPSAKRE GFVTVPNVTW ADIGALEDIR EELTMAILAP 600
VRNPDQFKAL GLVTPAGVLL AGPPGCGKTL LAKAVANESG LNFISVKGPE 650
LLNMYVGESE RAVRQVFQRA KNSAPCVIFF DEVDALCPRR SDRETGASVR 700
VVNQLLTEMD GLEARQQVFI MAATNRPDII DPAILRPGRL DKTLFVGLPP 750
PADRLAILKT ITKNGTKPPL DADVNLEAIA GDLRCDCYTG ADLSALVREA 800
SICALRQEMA RQKSGNEKGE LKVSHKHFEE AFKKVRSSIS KKDQIMYERL 850
QESLSR 856
Length:856
Mass (Da):95,051
Last modified:January 1, 1998 - v1
Checksum:i7A8B373FCAFB99B7
GO
Isoform 2 (identifier: O15381-2) [UniParc]FASTAAdd to Basket

Also known as: NVLp.1

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:750
Mass (Da):82,746
Checksum:i56AF88DF9129D618
GO
Isoform 3 (identifier: O15381-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.
     115-205: Missing.

Note: No experimental confirmation available.

Show »
Length:659
Mass (Da):72,733
Checksum:i0728D502901260F5
GO
Isoform 4 (identifier: O15381-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.
     320-320: G → GAECSGMITAHCSFDFSGSNDPPASASQ

Show »
Length:667
Mass (Da):73,280
Checksum:iE46F119F9E1C345A
GO
Isoform 5 (identifier: O15381-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-205: Missing.

Show »
Length:765
Mass (Da):85,038
Checksum:iA34DEE65ED8A82D6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti295 – 2951V → I.
Corresponds to variant rs12084919 [ dbSNP | Ensembl ].
VAR_048109
Natural varianti359 – 3591C → G.1 Publication
VAR_015890
Natural varianti404 – 4041V → I.
Corresponds to variant rs34631151 [ dbSNP | Ensembl ].
VAR_048110

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 216216Missing in isoform 4.
VSP_045334Add
BLAST
Alternative sequencei1 – 106106Missing in isoform 2 and isoform 3.
VSP_007771Add
BLAST
Alternative sequencei115 – 20591Missing in isoform 3 and isoform 5.
VSP_007772Add
BLAST
Alternative sequencei320 – 3201G → GAECSGMITAHCSFDFSGSN DPPASASQ in isoform 4.
VSP_045335

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U68140 mRNA. Translation: AAB70457.1.
U78772 mRNA. Translation: AAB70460.1.
AK297396 mRNA. Translation: BAG59836.1.
AK298244 mRNA. Translation: BAG60510.1.
AC092809 Genomic DNA. No translation available.
BC012105 mRNA. Translation: AAH12105.1.
CCDSiCCDS1541.1. [O15381-1]
CCDS1542.1. [O15381-2]
CCDS58062.1. [O15381-4]
CCDS58063.1. [O15381-5]
RefSeqiNP_001230075.1. NM_001243146.1. [O15381-4]
NP_001230076.1. NM_001243147.1. [O15381-5]
NP_002524.2. NM_002533.3. [O15381-1]
NP_996671.1. NM_206840.2. [O15381-2]
UniGeneiHs.497867.

Genome annotation databases

EnsembliENST00000281701; ENSP00000281701; ENSG00000143748. [O15381-1]
ENST00000340871; ENSP00000341362; ENSG00000143748. [O15381-4]
ENST00000391875; ENSP00000375747; ENSG00000143748. [O15381-2]
ENST00000469075; ENSP00000417826; ENSG00000143748. [O15381-5]
GeneIDi4931.
KEGGihsa:4931.
UCSCiuc001hok.3. human. [O15381-1]
uc010pvd.2. human.
uc010pve.2. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U68140 mRNA. Translation: AAB70457.1 .
U78772 mRNA. Translation: AAB70460.1 .
AK297396 mRNA. Translation: BAG59836.1 .
AK298244 mRNA. Translation: BAG60510.1 .
AC092809 Genomic DNA. No translation available.
BC012105 mRNA. Translation: AAH12105.1 .
CCDSi CCDS1541.1. [O15381-1 ]
CCDS1542.1. [O15381-2 ]
CCDS58062.1. [O15381-4 ]
CCDS58063.1. [O15381-5 ]
RefSeqi NP_001230075.1. NM_001243146.1. [O15381-4 ]
NP_001230076.1. NM_001243147.1. [O15381-5 ]
NP_002524.2. NM_002533.3. [O15381-1 ]
NP_996671.1. NM_206840.2. [O15381-2 ]
UniGenei Hs.497867.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2X8A X-ray 2.60 A 574-845 [» ]
ProteinModelPortali O15381.
SMRi O15381. Positions 1-74, 256-854.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110985. 7 interactions.
IntActi O15381. 4 interactions.
MINTi MINT-1423251.
STRINGi 9606.ENSP00000281701.

PTM databases

PhosphoSitei O15381.

2D gel databases

SWISS-2DPAGE O15381.

Proteomic databases

MaxQBi O15381.
PaxDbi O15381.
PRIDEi O15381.

Protocols and materials databases

DNASUi 4931.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281701 ; ENSP00000281701 ; ENSG00000143748 . [O15381-1 ]
ENST00000340871 ; ENSP00000341362 ; ENSG00000143748 . [O15381-4 ]
ENST00000391875 ; ENSP00000375747 ; ENSG00000143748 . [O15381-2 ]
ENST00000469075 ; ENSP00000417826 ; ENSG00000143748 . [O15381-5 ]
GeneIDi 4931.
KEGGi hsa:4931.
UCSCi uc001hok.3. human. [O15381-1 ]
uc010pvd.2. human.
uc010pve.2. human.

Organism-specific databases

CTDi 4931.
GeneCardsi GC01M224416.
HGNCi HGNC:8070. NVL.
HPAi HPA028207.
MIMi 602426. gene.
neXtProti NX_O15381.
PharmGKBi PA31857.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0464.
HOGENOMi HOG000223225.
HOVERGENi HBG001226.
InParanoidi O15381.
KOi K14571.
OMAi ELHMCIV.
PhylomeDBi O15381.
TreeFami TF314681.

Miscellaneous databases

ChiTaRSi NVL. human.
EvolutionaryTracei O15381.
GeneWikii NVL_(gene).
GenomeRNAii 4931.
NextBioi 19001.
PROi O15381.
SOURCEi Search...

Gene expression databases

ArrayExpressi O15381.
Bgeei O15381.
CleanExi HS_NVL.
Genevestigatori O15381.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00674. AAA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NVL: a new member of the AAA family of ATPases localized to the nucleus."
    Germain-Lee E.L., Obie C., Valle D.
    Genomics 44:22-34(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT GLY-359, PHOSPHORYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
    Tissue: Brain.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Eye.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134 AND THR-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134; THR-138; SER-211 AND SER-215, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal."
    Fujiwara Y., Fujiwara K., Goda N., Iwaya N., Tenno T., Shirakawa M., Hiroaki H.
    J. Biol. Chem. 286:21732-21741(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NCL/NUCLEOLIN.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Human nuclear valosin containing protein like (NVL), C-terminal AAA-ATPase domain."
    Structural genomics consortium (SGC)
    Submitted (MAR-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 574-845 IN COMPLEX WITH PHOSPHATE.

Entry informationi

Entry nameiNVL_HUMAN
AccessioniPrimary (citable) accession number: O15381
Secondary accession number(s): B4DMC4, B4DP98, Q96EM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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