UniProtKB - O15375 (MOT6_HUMAN)
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Protein
Monocarboxylate transporter 6
Gene
SLC16A5
Organism
Homo sapiens (Human)
Status
Functioni
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity
GO - Molecular functioni
- monocarboxylic acid transmembrane transporter activity Source: GO_Central
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- monocarboxylic acid transport Source: ProtInc
Keywordsi
Biological process | Symport, Transport |
Protein family/group databases
TCDBi | 2.A.1.13.11. the major facilitator superfamily (mfs). |
Names & Taxonomyi
Protein namesi | Recommended name: Monocarboxylate transporter 6Short name: MCT 6 Alternative name(s): Monocarboxylate transporter 5 Short name: MCT 5 Solute carrier family 16 member 5 |
Gene namesi | Name:SLC16A5 Synonyms:MCT5, MCT6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170190.15. |
HGNCi | HGNC:10926. SLC16A5. |
MIMi | 603879. gene. |
neXtProti | NX_O15375. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 17 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 18 – 38 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 39 – 53 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 54 – 74 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 75 – 80 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 102 – 110 | ExtracellularSequence analysis | 9 | |
Transmembranei | 111 – 131 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 132 – 137 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 138 – 158 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 159 – 171 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 172 – 192 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 193 – 239 | CytoplasmicSequence analysisAdd BLAST | 47 | |
Transmembranei | 240 – 260 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 261 – 274 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 275 – 295 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 296 – 305 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 306 – 326 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 327 – 329 | ExtracellularSequence analysis | 3 | |
Transmembranei | 330 – 350 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 351 – 367 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 368 – 388 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 389 – 396 | ExtracellularSequence analysis | 8 | |
Transmembranei | 397 – 417 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 418 – 505 | CytoplasmicSequence analysisAdd BLAST | 88 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9121. |
OpenTargetsi | ENSG00000170190. |
PharmGKBi | PA35817. |
Chemistry databases
DrugBanki | DB00119. Pyruvic acid. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211399 | 1 – 505 | Monocarboxylate transporter 6Add BLAST | 505 |
Proteomic databases
MaxQBi | O15375. |
PaxDbi | O15375. |
PeptideAtlasi | O15375. |
PRIDEi | O15375. |
PTM databases
iPTMneti | O15375. |
PhosphoSitePlusi | O15375. |
Expressioni
Tissue specificityi
Highly expressed in kidney.
Gene expression databases
Bgeei | ENSG00000170190. |
CleanExi | HS_SLC16A5. |
ExpressionAtlasi | O15375. baseline and differential. |
Genevisiblei | O15375. HS. |
Interactioni
Protein-protein interaction databases
BioGridi | 114569. 1 interactor. |
IntActi | O15375. 2 interactors. |
STRINGi | 9606.ENSP00000330141. |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2504. Eukaryota. COG0477. LUCA. |
GeneTreei | ENSGT00760000118926. |
HOGENOMi | HOG000280688. |
HOVERGENi | HBG006384. |
InParanoidi | O15375. |
KOi | K08182. |
OMAi | HCCVCGA. |
OrthoDBi | EOG091G05SW. |
PhylomeDBi | O15375. |
TreeFami | TF313792. |
Family and domain databases
CDDi | cd06174. MFS. 1 hit. |
InterProi | View protein in InterPro IPR004743. MCT. IPR030760. MCT6. IPR011701. MFS. IPR020846. MFS_dom. IPR036259. MFS_trans_sf. |
PANTHERi | PTHR11360:SF21. PTHR11360:SF21. 1 hit. |
Pfami | View protein in Pfam PF07690. MFS_1. 1 hit. |
SUPFAMi | SSF103473. SSF103473. 1 hit. |
TIGRFAMsi | TIGR00892. 2A0113. 1 hit. |
PROSITEi | View protein in PROSITE PS50850. MFS. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: O15375-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MPQALERADG SWAWVVLLAT MVTQGLTLGF PTCIGIFFTE LQWEFQASNS
60 70 80 90 100
ETSWFPSILT AVLHMAGPLC SILVGRFGCR VTVMLGGVLA SLGMVASSFS
110 120 130 140 150
HNLSQLYFTA GFITGLGMCF SFQSSITVLG FYFVRRRVLA NALASMGVSL
160 170 180 190 200
GITLWPLLSR YLLENLGWRG TFLVFGGIFL HCCICGAIIR PVATSVAPET
210 220 230 240 250
KECPPPPPET PALGCLAACG RTIQRHLAFD ILRHNTGYCV YILGVMWSVL
260 270 280 290 300
GFPLPQVFLV PYAMWHSVDE QQAALLISII GFSNIFLRPL AGLMAGRPAF
310 320 330 340 350
ASHRKYLFSL ALLLNGLTNL VCAASGDFWV LVGYCLAYSV SMSGIGALIF
360 370 380 390 400
QVLMDIVPMD QFPRALGLFT VLDGLAFLIS PPLAGLLLDA TNNFSYVFYM
410 420 430 440 450
SSFFLISAAL FMGGSFYALQ KKEQGKQAVA ADALERDLFL EAKDGPGKQR
460 470 480 490 500
SPEIMCQSSR QPRPAGVNKH LWGCPASSRT SHEWLLWPKA VLQAKQTALG
WNSPT
Isoform 2 (identifier: O15375-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MPRPTRGPLATSQGWCPSVTPGTWAAATLAVRPWQRRQQRM
456-505: CQSSRQPRPAGVNKHLWGCPASSRTSHEWLLWPKAVLQAKQTALGWNSPT → YVTSV
Note: No experimental confirmation available.
Show »Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056660 | 1 | M → MPRPTRGPLATSQGWCPSVT PGTWAAATLAVRPWQRRQQR M in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_056661 | 456 – 505 | CQSSR…WNSPT → YVTSV in isoform 2. 1 PublicationAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U59299 mRNA. Translation: AAC52013.1. AK304163 mRNA. Translation: BAG65050.1. AC111186 Genomic DNA. No translation available. BC009684 mRNA. Translation: AAH09684.1. BC033611 mRNA. Translation: AAH33611.1. |
CCDSi | CCDS11713.1. [O15375-1] |
RefSeqi | NP_001258694.1. NM_001271765.1. [O15375-1] NP_004686.1. NM_004695.3. [O15375-1] |
UniGenei | Hs.592095. |
Genome annotation databases
Ensembli | ENST00000329783; ENSP00000330141; ENSG00000170190. [O15375-1] ENST00000450736; ENSP00000390564; ENSG00000170190. [O15375-1] ENST00000538213; ENSP00000440212; ENSG00000170190. [O15375-2] ENST00000580123; ENSP00000463434; ENSG00000170190. [O15375-1] |
GeneIDi | 9121. |
KEGGi | hsa:9121. |
UCSCi | uc002jmr.5. human. [O15375-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | MOT6_HUMAN | |
Accessioni | O15375Primary (citable) accession number: O15375 Secondary accession number(s): B4E288 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 28, 2018 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |