SLC16A5

Functionⁱ

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functionⁱ

monocarboxylic acid transmembrane transporter activity Source: GO_Central
symporter activity Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

monocarboxylic acid transport
Source: ProtInc
Traceable author statementⁱ
- 9425115

Complete GO annotation...

Keywordsⁱ

Biological process	Symport, Transport

Biological process

Symport, Transport

Protein family/group databases

TCDBⁱ	2.A.1.13.11. the major facilitator superfamily (mfs).

TCDBⁱ

2.A.1.13.11. the major facilitator superfamily (mfs).

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Monocarboxylate transporter 6 Short name: MCT 6 Alternative name(s): Monocarboxylate transporter 5 Short name: MCT 5 Solute carrier family 16 member 5
Gene namesⁱ	Name:SLC16A5 Synonyms:MCT5, MCT6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10926. SLC16A5.

HGNCⁱ

HGNC:10926. SLC16A5.

Subcellular locationⁱ

Cell membrane; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 17	CytoplasmicSequence analysisAdd BLAST	17
Transmembraneⁱ	18 – 38	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	39 – 53	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	54 – 74	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	75 – 80	CytoplasmicSequence analysis	6
Transmembraneⁱ	81 – 101	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	102 – 110	ExtracellularSequence analysis	9
Transmembraneⁱ	111 – 131	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	132 – 137	CytoplasmicSequence analysis	6
Transmembraneⁱ	138 – 158	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	159 – 171	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	172 – 192	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	193 – 239	CytoplasmicSequence analysisAdd BLAST	47
Transmembraneⁱ	240 – 260	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	261 – 274	ExtracellularSequence analysisAdd BLAST	14
Transmembraneⁱ	275 – 295	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	296 – 305	CytoplasmicSequence analysis	10
Transmembraneⁱ	306 – 326	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	327 – 329	ExtracellularSequence analysis	3
Transmembraneⁱ	330 – 350	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	351 – 367	CytoplasmicSequence analysisAdd BLAST	17
Transmembraneⁱ	368 – 388	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	389 – 396	ExtracellularSequence analysis	8
Transmembraneⁱ	397 – 417	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	418 – 505	CytoplasmicSequence analysisAdd BLAST	88

GO - Cellular componentⁱ

integral component of plasma membrane
Source: ProtInc
Traceable author statementⁱ
- 9425115
membrane
Source: ProtInc
Traceable author statementⁱ
- 9425115

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000170190.
PharmGKBⁱ	PA35817.

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00119. Pyruvic acid.

DrugBankⁱ

DB00119. Pyruvic acid.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000211399	1 – 505	Monocarboxylate transporter 6Add BLAST		505

Proteomic databases

EPDⁱ	O15375.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O15375.
PaxDbⁱ	O15375.
PeptideAtlas More...PeptideAtlasⁱ	O15375.
PRIDEⁱ	O15375.

PTM databases

iPTMnetⁱ	O15375.
PhosphoSitePlusⁱ	O15375.

Expressionⁱ

Tissue specificityⁱ

Highly expressed in kidney.

Gene expression databases

Bgeeⁱ	ENSG00000170190.
CleanExⁱ	HS_SLC16A5.
ExpressionAtlasⁱ	O15375. baseline and differential.
Genevisibleⁱ	O15375. HS.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114569. 1 interactor.
IntActⁱ	O15375. 2 interactors.
STRINGⁱ	9606.ENSP00000330141.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O15375.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2504. Eukaryota. COG0477. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118926.
HOGENOMⁱ	HOG000280688.
HOVERGENⁱ	HBG006384.
InParanoidⁱ	O15375.
KEGG Orthology (KO) More...KOⁱ	K08182.
OMAⁱ	HCCVCGA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05SW.
PhylomeDBⁱ	O15375.
TreeFamⁱ	TF313792.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174. MFS. 1 hit.
InterProⁱ	View protein in InterPro IPR004743. MCT. IPR030760. MCT6. IPR011701. MFS. IPR020846. MFS_dom.
PANTHERⁱ	PTHR11360:SF205. PTHR11360:SF205. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07690. MFS_1. 1 hit.
SUPFAMⁱ	SSF103473. SSF103473. 1 hit.
TIGRFAMsⁱ	TIGR00892. 2A0113. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50850. MFS. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: O15375-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQALERADG SWAWVVLLAT MVTQGLTLGF PTCIGIFFTE LQWEFQASNS 
        60         70         80         90        100
ETSWFPSILT AVLHMAGPLC SILVGRFGCR VTVMLGGVLA SLGMVASSFS 
       110        120        130        140        150
HNLSQLYFTA GFITGLGMCF SFQSSITVLG FYFVRRRVLA NALASMGVSL 
       160        170        180        190        200
GITLWPLLSR YLLENLGWRG TFLVFGGIFL HCCICGAIIR PVATSVAPET 
       210        220        230        240        250
KECPPPPPET PALGCLAACG RTIQRHLAFD ILRHNTGYCV YILGVMWSVL 
       260        270        280        290        300
GFPLPQVFLV PYAMWHSVDE QQAALLISII GFSNIFLRPL AGLMAGRPAF 
       310        320        330        340        350
ASHRKYLFSL ALLLNGLTNL VCAASGDFWV LVGYCLAYSV SMSGIGALIF 
       360        370        380        390        400
QVLMDIVPMD QFPRALGLFT VLDGLAFLIS PPLAGLLLDA TNNFSYVFYM 
       410        420        430        440        450
SSFFLISAAL FMGGSFYALQ KKEQGKQAVA ADALERDLFL EAKDGPGKQR 
       460        470        480        490        500
SPEIMCQSSR QPRPAGVNKH LWGCPASSRT SHEWLLWPKA VLQAKQTALG 

WNSPT

Length:505

Mass (Da):54,994

Last modified:January 1, 1998 - v1

Checksum:ⁱE0F7B4BD607D2364

GO

Isoform 2 (identifier: O15375-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MPRPTRGPLATSQGWCPSVTPGTWAAATLAVRPWQRRQQRM
456-505: CQSSRQPRPAGVNKHLWGCPASSRTSHEWLLWPKAVLQAKQTALGWNSPT → YVTSV

« Hide

        10         20         30         40         50
MPRPTRGPLA TSQGWCPSVT PGTWAAATLA VRPWQRRQQR MPQALERADG 
        60         70         80         90        100
SWAWVVLLAT MVTQGLTLGF PTCIGIFFTE LQWEFQASNS ETSWFPSILT 
       110        120        130        140        150
AVLHMAGPLC SILVGRFGCR VTVMLGGVLA SLGMVASSFS HNLSQLYFTA 
       160        170        180        190        200
GFITGLGMCF SFQSSITVLG FYFVRRRVLA NALASMGVSL GITLWPLLSR 
       210        220        230        240        250
YLLENLGWRG TFLVFGGIFL HCCICGAIIR PVATSVAPET KECPPPPPET 
       260        270        280        290        300
PALGCLAACG RTIQRHLAFD ILRHNTGYCV YILGVMWSVL GFPLPQVFLV 
       310        320        330        340        350
PYAMWHSVDE QQAALLISII GFSNIFLRPL AGLMAGRPAF ASHRKYLFSL 
       360        370        380        390        400
ALLLNGLTNL VCAASGDFWV LVGYCLAYSV SMSGIGALIF QVLMDIVPMD 
       410        420        430        440        450
QFPRALGLFT VLDGLAFLIS PPLAGLLLDA TNNFSYVFYM SSFFLISAAL 
       460        470        480        490        500
FMGGSFYALQ KKEQGKQAVA ADALERDLFL EAKDGPGKQR SPEIMYVTSV

Note: No experimental confirmation available.

Show »

Length:500

Mass (Da):54,449

Checksum:ⁱ04108AC8476765C6

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056660	1	M → MPRPTRGPLATSQGWCPSVT PGTWAAATLAVRPWQRRQQR M in isoform 2. 1 Publication		1
Alternative sequenceⁱVSP_056661	456 – 505	CQSSR…WNSPT → YVTSV in isoform 2. 1 PublicationAdd BLAST		50

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U59299 mRNA. Translation: AAC52013.1. AK304163 mRNA. Translation: BAG65050.1. AC111186 Genomic DNA. No translation available. BC009684 mRNA. Translation: AAH09684.1. BC033611 mRNA. Translation: AAH33611.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11713.1. [O15375-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001258694.1. NM_001271765.1. [O15375-1] NP_004686.1. NM_004695.3. [O15375-1]
UniGeneⁱ	Hs.592095.

Genome annotation databases

Ensemblⁱ	ENST00000329783; ENSP00000330141; ENSG00000170190. [O15375-1] ENST00000450736; ENSP00000390564; ENSG00000170190. [O15375-1] ENST00000538213; ENSP00000440212; ENSG00000170190. [O15375-2] ENST00000580123; ENSP00000463434; ENSG00000170190. [O15375-1]
GeneIDⁱ	9121.
KEGGⁱ	hsa:9121.
UCSC genome browser More...UCSCⁱ	uc002jmr.5. human. [O15375-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U59299 mRNA. Translation: AAC52013.1. AK304163 mRNA. Translation: BAG65050.1. AC111186 Genomic DNA. No translation available. BC009684 mRNA. Translation: AAH09684.1. BC033611 mRNA. Translation: AAH33611.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11713.1. [O15375-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001258694.1. NM_001271765.1. [O15375-1] NP_004686.1. NM_004695.3. [O15375-1]
UniGeneⁱ	Hs.592095.

3D structure databases

ProteinModelPortalⁱ	O15375.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114569. 1 interactor.
IntActⁱ	O15375. 2 interactors.
STRINGⁱ	9606.ENSP00000330141.

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00119. Pyruvic acid.

DrugBankⁱ

DB00119. Pyruvic acid.

Protein family/group databases

TCDBⁱ	2.A.1.13.11. the major facilitator superfamily (mfs).

TCDBⁱ

2.A.1.13.11. the major facilitator superfamily (mfs).

PTM databases

iPTMnetⁱ	O15375.
PhosphoSitePlusⁱ	O15375.

Proteomic databases

EPDⁱ	O15375.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O15375.
PaxDbⁱ	O15375.
PeptideAtlas More...PeptideAtlasⁱ	O15375.
PRIDEⁱ	O15375.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9121.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000329783; ENSP00000330141; ENSG00000170190. [O15375-1] ENST00000450736; ENSP00000390564; ENSG00000170190. [O15375-1] ENST00000538213; ENSP00000440212; ENSG00000170190. [O15375-2] ENST00000580123; ENSP00000463434; ENSG00000170190. [O15375-1]
GeneIDⁱ	9121.
KEGGⁱ	hsa:9121.
UCSC genome browser More...UCSCⁱ	uc002jmr.5. human. [O15375-1]

Organism-specific databases

CTDⁱ	9121.
GeneCardsⁱ	SLC16A5.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10926. SLC16A5.
MIMⁱ	603879. gene.
neXtProtⁱ	NX_O15375.
Open Targets More...OpenTargetsⁱ	ENSG00000170190.
PharmGKBⁱ	PA35817.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2504. Eukaryota. COG0477. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118926.
HOGENOMⁱ	HOG000280688.
HOVERGENⁱ	HBG006384.
InParanoidⁱ	O15375.
KEGG Orthology (KO) More...KOⁱ	K08182.
OMAⁱ	HCCVCGA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05SW.
PhylomeDBⁱ	O15375.
TreeFamⁱ	TF313792.

Miscellaneous databases

GenomeRNAiⁱ	9121.
Protein Ontology More...PROⁱ	PR:O15375.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170190.
CleanExⁱ	HS_SLC16A5.
ExpressionAtlasⁱ	O15375. baseline and differential.
Genevisibleⁱ	O15375. HS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174. MFS. 1 hit.
InterProⁱ	View protein in InterPro IPR004743. MCT. IPR030760. MCT6. IPR011701. MFS. IPR020846. MFS_dom.
PANTHERⁱ	PTHR11360:SF205. PTHR11360:SF205. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07690. MFS_1. 1 hit.
SUPFAMⁱ	SSF103473. SSF103473. 1 hit.
TIGRFAMsⁱ	TIGR00892. 2A0113. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50850. MFS. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MOT6_HUMAN
Accessionⁱ	O15375Primary (citable) accession number: O15375 Secondary accession number(s): B4E288
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	January 1, 1998
	Last modified:	July 5, 2017
	This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O15375 (MOT6_HUMAN)

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Monocarboxylate transporter 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ