Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor SOX-12

Gene

SOX12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the sequence 5'-AACAAT-3'.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi40 – 10869HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-12
Alternative name(s):
Protein SOX-22
Gene namesi
Name:SOX12
Synonyms:SOX22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:11198. SOX12.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Transcription factor SOX-12PRO_0000048754Add
BLAST

Proteomic databases

MaxQBiO15370.
PaxDbiO15370.
PRIDEiO15370.

PTM databases

PhosphoSiteiO15370.

Expressioni

Tissue specificityi

Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart, pancreas, testis and ovary. Other tissues were only weakly positive.1 Publication

Gene expression databases

BgeeiO15370.
CleanExiHS_SOX12.
GenevisibleiO15370. HS.

Interactioni

Protein-protein interaction databases

BioGridi112549. 3 interactions.
IntActiO15370. 3 interactions.
STRINGi9606.ENSP00000347646.

Structurei

3D structure databases

ProteinModelPortaliO15370.
SMRiO15370. Positions 38-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 228Poly-Pro
Compositional biasi211 – 2177Poly-Ala
Compositional biasi223 – 25028Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi223 – 23311Poly-GluAdd
BLAST
Compositional biasi234 – 2374Poly-Ala

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG290369.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231874.
HOVERGENiHBG094895.
InParanoidiO15370.
KOiK09268.
OMAiEPAWCKT.
OrthoDBiEOG7TMZVP.
PhylomeDBiO15370.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR031267. SOX-12.
[Graphical view]
PANTHERiPTHR10270:SF209. PTHR10270:SF209. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQQRGARAK RDGGPPPPGP GPAEEGAREP GWCKTPSGHI KRPMNAFMVW
60 70 80 90 100
SQHERRKIMD QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH
110 120 130 140 150
MADYPDYKYR PRKKSKGAPA KARPRPPGGS GGGSRLKPGP QLPGRGGRRA
160 170 180 190 200
AGGPLGGGAA APEDDDEDDD EELLEVRLVE TPGRELWRMV PAGRAARGQA
210 220 230 240 250
ERAQGPSGEG AAAAAAASPT PSEDEEPEEE EEEAAAAEEG EEETVASGEE
260 270 280 290 300
SLGFLSRLPP GPAGLDCSAL DRDPDLQPPS GTSHFEFPDY CTPEVTEMIA
310
GDWRPSSIAD LVFTY
Length:315
Mass (Da):34,122
Last modified:October 3, 2006 - v2
Checksum:iA5BF539AC505942D
GO

Sequence cautioni

The sequence AAB69627.1 differs from that shown. Reason: Frameshift at positions 135 and 201. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35612 mRNA. Translation: AAB69627.1. Frameshift.
AL034548 Genomic DNA. Translation: CAB81632.1.
BC067361 mRNA. Translation: AAH67361.1.
CCDSiCCDS12995.1.
RefSeqiNP_008874.2. NM_006943.3.
UniGeneiHs.43627.
Hs.712815.
Hs.745045.
Hs.745058.

Genome annotation databases

EnsembliENST00000342665; ENSP00000347646; ENSG00000177732.
GeneIDi6666.
KEGGihsa:6666.
UCSCiuc002wdh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35612 mRNA. Translation: AAB69627.1. Frameshift.
AL034548 Genomic DNA. Translation: CAB81632.1.
BC067361 mRNA. Translation: AAH67361.1.
CCDSiCCDS12995.1.
RefSeqiNP_008874.2. NM_006943.3.
UniGeneiHs.43627.
Hs.712815.
Hs.745045.
Hs.745058.

3D structure databases

ProteinModelPortaliO15370.
SMRiO15370. Positions 38-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112549. 3 interactions.
IntActiO15370. 3 interactions.
STRINGi9606.ENSP00000347646.

PTM databases

PhosphoSiteiO15370.

Proteomic databases

MaxQBiO15370.
PaxDbiO15370.
PRIDEiO15370.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342665; ENSP00000347646; ENSG00000177732.
GeneIDi6666.
KEGGihsa:6666.
UCSCiuc002wdh.4. human.

Organism-specific databases

CTDi6666.
GeneCardsiGC20P000306.
HGNCiHGNC:11198. SOX12.
MIMi601947. gene.
neXtProtiNX_O15370.
PharmGKBiPA36035.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG290369.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231874.
HOVERGENiHBG094895.
InParanoidiO15370.
KOiK09268.
OMAiEPAWCKT.
OrthoDBiEOG7TMZVP.
PhylomeDBiO15370.
TreeFamiTF351735.

Miscellaneous databases

ChiTaRSiSOX12. human.
GeneWikiiSOX12.
GenomeRNAii6666.
NextBioi25991.
PROiO15370.
SOURCEiSearch...

Gene expression databases

BgeeiO15370.
CleanExiHS_SOX12.
GenevisibleiO15370. HS.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR031267. SOX-12.
[Graphical view]
PANTHERiPTHR10270:SF209. PTHR10270:SF209. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue."
    Jay P., Sahly I., Goze C., Taviaux S., Poulat F., Couly G., Abitbol M., Berta P.
    Hum. Mol. Genet. 6:1069-1077(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiSOX12_HUMAN
AccessioniPrimary (citable) accession number: O15370
Secondary accession number(s): Q5D038, Q9NUD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2006
Last modified: July 22, 2015
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.