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O15370

- SOX12_HUMAN

UniProt

O15370 - SOX12_HUMAN

Protein

Transcription factor SOX-12

Gene

SOX12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Binds to the sequence 5'-AACAAT-3'.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi40 – 10869HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
    3. RNA polymerase II transcription coactivator activity Source: UniProtKB
    4. transcription regulatory region sequence-specific DNA binding Source: UniProtKB

    GO - Biological processi

    1. cell fate commitment Source: UniProtKB
    2. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    3. protein-DNA complex assembly Source: Ensembl
    4. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    5. spinal cord development Source: UniProtKB

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-12
    Alternative name(s):
    Protein SOX-22
    Gene namesi
    Name:SOX12
    Synonyms:SOX22
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:11198. SOX12.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. protein-DNA complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36035.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Transcription factor SOX-12PRO_0000048754Add
    BLAST

    Proteomic databases

    MaxQBiO15370.
    PaxDbiO15370.
    PRIDEiO15370.

    PTM databases

    PhosphoSiteiO15370.

    Expressioni

    Tissue specificityi

    Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart, pancreas, testis and ovary. Other tissues were only weakly positive.1 Publication

    Gene expression databases

    BgeeiO15370.
    CleanExiHS_SOX12.
    GenevestigatoriO15370.

    Interactioni

    Protein-protein interaction databases

    BioGridi112549. 4 interactions.
    IntActiO15370. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO15370.
    SMRiO15370. Positions 38-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 228Poly-Pro
    Compositional biasi211 – 2177Poly-Ala
    Compositional biasi223 – 25028Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi223 – 23311Poly-GluAdd
    BLAST
    Compositional biasi234 – 2374Poly-Ala

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG290369.
    HOGENOMiHOG000231874.
    HOVERGENiHBG094895.
    InParanoidiO15370.
    KOiK09268.
    OMAiMVQQRGA.
    OrthoDBiEOG7TMZVP.
    PhylomeDBiO15370.
    TreeFamiTF351735.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR017386. SOX-12/11/4a.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038098. SOX-12/11/4a. 1 hit.
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O15370-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQQRGARAK RDGGPPPPGP GPAEEGAREP GWCKTPSGHI KRPMNAFMVW    50
    SQHERRKIMD QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH 100
    MADYPDYKYR PRKKSKGAPA KARPRPPGGS GGGSRLKPGP QLPGRGGRRA 150
    AGGPLGGGAA APEDDDEDDD EELLEVRLVE TPGRELWRMV PAGRAARGQA 200
    ERAQGPSGEG AAAAAAASPT PSEDEEPEEE EEEAAAAEEG EEETVASGEE 250
    SLGFLSRLPP GPAGLDCSAL DRDPDLQPPS GTSHFEFPDY CTPEVTEMIA 300
    GDWRPSSIAD LVFTY 315
    Length:315
    Mass (Da):34,122
    Last modified:October 3, 2006 - v2
    Checksum:iA5BF539AC505942D
    GO

    Sequence cautioni

    The sequence AAB69627.1 differs from that shown. Reason: Frameshift at positions 135 and 201.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35612 mRNA. Translation: AAB69627.1. Frameshift.
    AL034548 Genomic DNA. Translation: CAB81632.1.
    BC067361 mRNA. Translation: AAH67361.1.
    CCDSiCCDS12995.1.
    RefSeqiNP_008874.2. NM_006943.3.
    UniGeneiHs.43627.
    Hs.712815.
    Hs.745045.
    Hs.745058.

    Genome annotation databases

    EnsembliENST00000342665; ENSP00000347646; ENSG00000177732.
    GeneIDi6666.
    KEGGihsa:6666.
    UCSCiuc002wdh.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35612 mRNA. Translation: AAB69627.1 . Frameshift.
    AL034548 Genomic DNA. Translation: CAB81632.1 .
    BC067361 mRNA. Translation: AAH67361.1 .
    CCDSi CCDS12995.1.
    RefSeqi NP_008874.2. NM_006943.3.
    UniGenei Hs.43627.
    Hs.712815.
    Hs.745045.
    Hs.745058.

    3D structure databases

    ProteinModelPortali O15370.
    SMRi O15370. Positions 38-113.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112549. 4 interactions.
    IntActi O15370. 3 interactions.

    PTM databases

    PhosphoSitei O15370.

    Proteomic databases

    MaxQBi O15370.
    PaxDbi O15370.
    PRIDEi O15370.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342665 ; ENSP00000347646 ; ENSG00000177732 .
    GeneIDi 6666.
    KEGGi hsa:6666.
    UCSCi uc002wdh.4. human.

    Organism-specific databases

    CTDi 6666.
    GeneCardsi GC20P000306.
    HGNCi HGNC:11198. SOX12.
    MIMi 601947. gene.
    neXtProti NX_O15370.
    PharmGKBi PA36035.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290369.
    HOGENOMi HOG000231874.
    HOVERGENi HBG094895.
    InParanoidi O15370.
    KOi K09268.
    OMAi MVQQRGA.
    OrthoDBi EOG7TMZVP.
    PhylomeDBi O15370.
    TreeFami TF351735.

    Miscellaneous databases

    GeneWikii SOX12.
    GenomeRNAii 6666.
    NextBioi 25991.
    PROi O15370.
    SOURCEi Search...

    Gene expression databases

    Bgeei O15370.
    CleanExi HS_SOX12.
    Genevestigatori O15370.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR017386. SOX-12/11/4a.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038098. SOX-12/11/4a. 1 hit.
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue."
      Jay P., Sahly I., Goze C., Taviaux S., Poulat F., Couly G., Abitbol M., Berta P.
      Hum. Mol. Genet. 6:1069-1077(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiSOX12_HUMAN
    AccessioniPrimary (citable) accession number: O15370
    Secondary accession number(s): Q5D038, Q9NUD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3