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Protein

Transcription factor SOX-12

Gene

SOX12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the sequence 5'-AACAAT-3'.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi40 – 108HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-12
Alternative name(s):
Protein SOX-22
Gene namesi
Name:SOX12
Synonyms:SOX22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000177732.7.
HGNCiHGNC:11198. SOX12.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6666.
OpenTargetsiENSG00000177732.
PharmGKBiPA36035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487541 – 315Transcription factor SOX-12Add BLAST315

Proteomic databases

EPDiO15370.
MaxQBiO15370.
PaxDbiO15370.
PeptideAtlasiO15370.
PRIDEiO15370.

PTM databases

iPTMnetiO15370.
PhosphoSitePlusiO15370.

Expressioni

Tissue specificityi

Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart, pancreas, testis and ovary. Other tissues were only weakly positive.1 Publication

Gene expression databases

BgeeiENSG00000177732.
CleanExiHS_SOX12.
GenevisibleiO15370. HS.

Organism-specific databases

HPAiHPA055052.
HPA061627.

Interactioni

Protein-protein interaction databases

BioGridi112549. 3 interactors.
IntActiO15370. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliO15370.
SMRiO15370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 22Poly-Pro8
Compositional biasi211 – 217Poly-Ala7
Compositional biasi223 – 250Asp/Glu-rich (acidic)Add BLAST28
Compositional biasi223 – 233Poly-GluAdd BLAST11
Compositional biasi234 – 237Poly-Ala4

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG4111TGC. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231874.
HOVERGENiHBG094895.
InParanoidiO15370.
KOiK09268.
OMAiGDWLMSS.
OrthoDBiEOG091G0F15.
PhylomeDBiO15370.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR036910. HMG_box_dom_sf.
IPR017386. SOX-11/4.
IPR031267. SOX-12.
PANTHERiPTHR10270:SF221. PTHR10270:SF221. 1 hit.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PIRSFiPIRSF038098. SOX-12/11/4a. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O15370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQQRGARAK RDGGPPPPGP GPAEEGAREP GWCKTPSGHI KRPMNAFMVW
60 70 80 90 100
SQHERRKIMD QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH
110 120 130 140 150
MADYPDYKYR PRKKSKGAPA KARPRPPGGS GGGSRLKPGP QLPGRGGRRA
160 170 180 190 200
AGGPLGGGAA APEDDDEDDD EELLEVRLVE TPGRELWRMV PAGRAARGQA
210 220 230 240 250
ERAQGPSGEG AAAAAAASPT PSEDEEPEEE EEEAAAAEEG EEETVASGEE
260 270 280 290 300
SLGFLSRLPP GPAGLDCSAL DRDPDLQPPS GTSHFEFPDY CTPEVTEMIA
310
GDWRPSSIAD LVFTY
Length:315
Mass (Da):34,122
Last modified:October 3, 2006 - v2
Checksum:iA5BF539AC505942D
GO

Sequence cautioni

O15370: The sequence AAB69627 differs from that shown. Reason: Frameshift at positions 135 and 201.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35612 mRNA. Translation: AAB69627.1. Frameshift.
AL034548 Genomic DNA. No translation available.
BC067361 mRNA. Translation: AAH67361.1.
CCDSiCCDS12995.1.
RefSeqiNP_008874.2. NM_006943.3.
UniGeneiHs.43627.
Hs.712815.
Hs.745045.
Hs.745058.

Genome annotation databases

EnsembliENST00000342665; ENSP00000347646; ENSG00000177732.
GeneIDi6666.
KEGGihsa:6666.
UCSCiuc002wdh.5. human.

Similar proteinsi

Entry informationi

Entry nameiSOX12_HUMAN
AccessioniPrimary (citable) accession number: O15370
Secondary accession number(s): Q5D038, Q9NUD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2006
Last modified: October 25, 2017
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot