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O15370

- SOX12_HUMAN

UniProt

O15370 - SOX12_HUMAN

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Protein

Transcription factor SOX-12

Gene
SOX12, SOX22
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to the sequence 5'-AACAAT-3' By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi40 – 10869HMG boxAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
  3. RNA polymerase II transcription coactivator activity Source: UniProtKB
  4. transcription regulatory region sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  1. cell fate commitment Source: UniProtKB
  2. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. protein-DNA complex assembly Source: Ensembl
  4. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  5. spinal cord development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-12
Alternative name(s):
Protein SOX-22
Gene namesi
Name:SOX12
Synonyms:SOX22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:11198. SOX12.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. protein-DNA complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Transcription factor SOX-12PRO_0000048754Add
BLAST

Proteomic databases

MaxQBiO15370.
PaxDbiO15370.
PRIDEiO15370.

PTM databases

PhosphoSiteiO15370.

Expressioni

Tissue specificityi

Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart, pancreas, testis and ovary. Other tissues were only weakly positive.1 Publication

Gene expression databases

BgeeiO15370.
CleanExiHS_SOX12.
GenevestigatoriO15370.

Interactioni

Protein-protein interaction databases

BioGridi112549. 4 interactions.
IntActiO15370. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliO15370.
SMRiO15370. Positions 38-113.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 228Poly-Pro
Compositional biasi211 – 2177Poly-Ala
Compositional biasi223 – 25028Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi223 – 23311Poly-GluAdd
BLAST
Compositional biasi234 – 2374Poly-Ala

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG290369.
HOGENOMiHOG000231874.
HOVERGENiHBG094895.
InParanoidiO15370.
KOiK09268.
OMAiMVQQRGA.
OrthoDBiEOG7TMZVP.
PhylomeDBiO15370.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR017386. SOX-12/11/4a.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFiPIRSF038098. SOX-12/11/4a. 1 hit.
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15370-1 [UniParc]FASTAAdd to Basket

« Hide

MVQQRGARAK RDGGPPPPGP GPAEEGAREP GWCKTPSGHI KRPMNAFMVW    50
SQHERRKIMD QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH 100
MADYPDYKYR PRKKSKGAPA KARPRPPGGS GGGSRLKPGP QLPGRGGRRA 150
AGGPLGGGAA APEDDDEDDD EELLEVRLVE TPGRELWRMV PAGRAARGQA 200
ERAQGPSGEG AAAAAAASPT PSEDEEPEEE EEEAAAAEEG EEETVASGEE 250
SLGFLSRLPP GPAGLDCSAL DRDPDLQPPS GTSHFEFPDY CTPEVTEMIA 300
GDWRPSSIAD LVFTY 315
Length:315
Mass (Da):34,122
Last modified:October 3, 2006 - v2
Checksum:iA5BF539AC505942D
GO

Sequence cautioni

The sequence AAB69627.1 differs from that shown. Reason: Frameshift at positions 135 and 201.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U35612 mRNA. Translation: AAB69627.1. Frameshift.
AL034548 Genomic DNA. Translation: CAB81632.1.
BC067361 mRNA. Translation: AAH67361.1.
CCDSiCCDS12995.1.
RefSeqiNP_008874.2. NM_006943.3.
UniGeneiHs.43627.
Hs.712815.
Hs.745045.
Hs.745058.

Genome annotation databases

EnsembliENST00000342665; ENSP00000347646; ENSG00000177732.
ENST00000544632; ENSP00000441671; ENSG00000177732.
GeneIDi6666.
KEGGihsa:6666.
UCSCiuc002wdh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U35612 mRNA. Translation: AAB69627.1 . Frameshift.
AL034548 Genomic DNA. Translation: CAB81632.1 .
BC067361 mRNA. Translation: AAH67361.1 .
CCDSi CCDS12995.1.
RefSeqi NP_008874.2. NM_006943.3.
UniGenei Hs.43627.
Hs.712815.
Hs.745045.
Hs.745058.

3D structure databases

ProteinModelPortali O15370.
SMRi O15370. Positions 38-113.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112549. 4 interactions.
IntActi O15370. 3 interactions.

PTM databases

PhosphoSitei O15370.

Proteomic databases

MaxQBi O15370.
PaxDbi O15370.
PRIDEi O15370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342665 ; ENSP00000347646 ; ENSG00000177732 .
ENST00000544632 ; ENSP00000441671 ; ENSG00000177732 .
GeneIDi 6666.
KEGGi hsa:6666.
UCSCi uc002wdh.4. human.

Organism-specific databases

CTDi 6666.
GeneCardsi GC20P000306.
HGNCi HGNC:11198. SOX12.
MIMi 601947. gene.
neXtProti NX_O15370.
PharmGKBi PA36035.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG290369.
HOGENOMi HOG000231874.
HOVERGENi HBG094895.
InParanoidi O15370.
KOi K09268.
OMAi MVQQRGA.
OrthoDBi EOG7TMZVP.
PhylomeDBi O15370.
TreeFami TF351735.

Miscellaneous databases

GeneWikii SOX12.
GenomeRNAii 6666.
NextBioi 25991.
PROi O15370.
SOURCEi Search...

Gene expression databases

Bgeei O15370.
CleanExi HS_SOX12.
Genevestigatori O15370.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
IPR017386. SOX-12/11/4a.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
PIRSFi PIRSF038098. SOX-12/11/4a. 1 hit.
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue."
    Jay P., Sahly I., Goze C., Taviaux S., Poulat F., Couly G., Abitbol M., Berta P.
    Hum. Mol. Genet. 6:1069-1077(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiSOX12_HUMAN
AccessioniPrimary (citable) accession number: O15370
Secondary accession number(s): Q5D038, Q9NUD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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