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Protein

Transcription factor SOX-12

Gene

SOX12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to the sequence 5'-AACAAT-3'.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi40 – 108HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-12
Alternative name(s):
Protein SOX-22
Gene namesi
Name:SOX12
Synonyms:SOX22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000177732.7
HGNCiHGNC:11198 SOX12
MIMi601947 gene
neXtProtiNX_O15370

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6666
OpenTargetsiENSG00000177732
PharmGKBiPA36035

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487541 – 315Transcription factor SOX-12Add BLAST315

Proteomic databases

EPDiO15370
MaxQBiO15370
PaxDbiO15370
PeptideAtlasiO15370
PRIDEiO15370
ProteomicsDBi48613

PTM databases

iPTMnetiO15370
PhosphoSitePlusiO15370

Expressioni

Tissue specificityi

Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart, pancreas, testis and ovary. Other tissues were only weakly positive.1 Publication

Gene expression databases

BgeeiENSG00000177732
CleanExiHS_SOX12
GenevisibleiO15370 HS

Organism-specific databases

HPAiHPA055052
HPA061627

Interactioni

Protein-protein interaction databases

BioGridi112549, 3 interactors
IntActiO15370, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliO15370
SMRiO15370
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 22Poly-Pro8
Compositional biasi211 – 217Poly-Ala7
Compositional biasi223 – 250Asp/Glu-rich (acidic)Add BLAST28
Compositional biasi223 – 233Poly-GluAdd BLAST11
Compositional biasi234 – 237Poly-Ala4

Phylogenomic databases

eggNOGiKOG0527 Eukaryota
ENOG4111TGC LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000231874
HOVERGENiHBG094895
InParanoidiO15370
KOiK09268
OMAiGDWLMSS
OrthoDBiEOG091G0F15
PhylomeDBiO15370
TreeFamiTF351735

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR017386 SOX-11/4
IPR031267 SOX-12
PANTHERiPTHR10270:SF221 PTHR10270:SF221, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PIRSFiPIRSF038098 SOX-12/11/4a, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O15370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQQRGARAK RDGGPPPPGP GPAEEGAREP GWCKTPSGHI KRPMNAFMVW
60 70 80 90 100
SQHERRKIMD QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH
110 120 130 140 150
MADYPDYKYR PRKKSKGAPA KARPRPPGGS GGGSRLKPGP QLPGRGGRRA
160 170 180 190 200
AGGPLGGGAA APEDDDEDDD EELLEVRLVE TPGRELWRMV PAGRAARGQA
210 220 230 240 250
ERAQGPSGEG AAAAAAASPT PSEDEEPEEE EEEAAAAEEG EEETVASGEE
260 270 280 290 300
SLGFLSRLPP GPAGLDCSAL DRDPDLQPPS GTSHFEFPDY CTPEVTEMIA
310
GDWRPSSIAD LVFTY
Length:315
Mass (Da):34,122
Last modified:October 3, 2006 - v2
Checksum:iA5BF539AC505942D
GO

Sequence cautioni

The sequence AAB69627 differs from that shown. Reason: Frameshift at positions 135 and 201.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35612 mRNA Translation: AAB69627.1 Frameshift.
AL034548 Genomic DNA No translation available.
BC067361 mRNA Translation: AAH67361.1
CCDSiCCDS12995.1
RefSeqiNP_008874.2, NM_006943.3
UniGeneiHs.43627
Hs.712815
Hs.745045
Hs.745058

Genome annotation databases

EnsembliENST00000342665; ENSP00000347646; ENSG00000177732
GeneIDi6666
KEGGihsa:6666
UCSCiuc002wdh.5 human

Similar proteinsi

Entry informationi

Entry nameiSOX12_HUMAN
AccessioniPrimary (citable) accession number: O15370
Secondary accession number(s): Q5D038, Q9NUD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2006
Last modified: June 20, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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