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Reviewed, UniProtKB/Swiss-Prot O15355 (PPM1G_HUMAN)

Last modified June 16, 2009. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein phosphatase 1G
    EC=3.1.3.16
Alternative name(s):
    Protein phosphatase 2C isoform gamma
      Short name=PP2C-gamma
    Protein phosphatase magnesium-dependent 1 gamma
    Protein phosphatase 1C
Gene names
Name: PPM1G
Synonyms: PPM1C
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length546 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

A phosphoprotein + H2O = a protein + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subcellular location

Cytoplasm Potential.

Tissue specificity

Widely expressed. Most abundant in testis, skeletal muscle, and heart.

Post-translational modification

Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.3 Ref.4

Sequence similarities

Belongs to the PP2C family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 546546Protein phosphatase 1G
PRO_0000057750

Regions

Compositional bias258 – 32669Asp/Glu-rich (acidic)
Compositional bias266 – 2727Poly-Glu
Compositional bias306 – 3116Poly-Glu
Compositional bias539 – 5446Poly-Lys

Sites

Metal binding601Manganese 1 By similarity
Metal binding601Manganese 2 By similarity
Metal binding611Manganese 1; via carbonyl oxygen By similarity
Metal binding4411Manganese 2 By similarity
Metal binding4961Manganese 2 By similarity

Amino acid modifications

Modified residue1831Phosphoserine Ref.4
Modified residue5271Phosphoserine Ref.3

Sequences

Sequence LengthMass (Da)Tools
O15355-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 084C16F8252330D9

FASTA54659,272
        10         20         30         40         50         60 
MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD SETAMFSVYD 

        70         80         90        100        110        120 
GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR 

       130        140        150        160        170        180 
PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGPPH SKSGGGTGEE 

       190        200        210        220        230        240 
PGSQGLNGEA GPEDSTRETP SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS 

       250        260        270        280        290        300 
CSSASDKLPR VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE 

       310        320        330        340        350        360 
AEEDDEEEEE EMMVPGMEGK EEPGSDSGTT AVVALIRGKQ LIVANAGDSR CVVSEAGKAL 

       370        380        390        400        410        420 
DMSYDHKPED EVELARIKNA GGKVTMDGRV NGGLNLSRAI GDHFYKRNKN LPPEEQMISA 

       430        440        450        460        470        480 
LPDIKVLTLT DDHEFMVIAC DGIWNVMSSQ EVVDFIQSKI SQRDENGELR LLSSIVEELL 

       490        500        510        520        530        540 
DQCLAPDTSG DGTGCDNMTC IIICFKPRNT AELQPESGKR KLEEVLSTEG AEENGNSDKK 


KKAKRD 

« Hide

References

« Hide 'large scale' references
[1]"PP2C gamma: a human protein phosphatase with a unique acidic domain."
Travis S.M., Welsh M.J.
FEBS Lett. 412:415-419(1997) [PubMed: 9276438] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta and Skin.
[3]"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry."
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-527, MASS SPECTROMETRY.
[4]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183, MASS SPECTROMETRY.
[5]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

Y13936 mRNA. Translation: CAA74245.1.
BC022061 mRNA. Translation: AAH22061.1.
BC000057 mRNA. Translation: AAH00057.1.
IPIIPI00006167.
RefSeqNP_002698.1.
NP_817092.1.
UniGeneHs.643951

3D structure databases

HSSPHSSP built from PDB template 1A6Q based on UniProtKB P35813.
ModBaseSearch...

Protein-protein interaction databases

IntActO15355. 3 interactions.

PTM databases

PhosphoSiteO15355.

Proteomic databases

PeptideAtlasO15355.
PRIDEO15355.

Genome annotation databases

EnsemblENSG00000115241. Homo sapiens. [Contig view]
GeneID5496.
KEGGhsa:5496.

Organism-specific databases

GeneCardsGC02M027457.
H-InvDBHIX0001922.
HGNCHGNC:9278. PPM1G.
MIM605119. gene.
PharmGKBPA33606.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO15355.
HOVERGENO15355.
OMAO15355. HSKSGAG.

Enzyme and pathway databases

BRENDA3.1.3.16. 247.

Gene expression databases

ArrayExpressO15355.
BgeeO15355.
CleanExHS_PPM1G.
GermOnlineENSG00000115241. Homo sapiens.

Family and domain databases

InterProIPR015655. PP2C.
IPR001932. PP2C-related.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR014045. PP2C_N.
[Graphical view]
Gene3DG3DSA:3.60.40.10. PP2C-related. 1 hit.
PANTHERPTHR13832. PP2C. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio21262.
SOURCESearch...

Entry information

Entry namePPM1G_HUMAN
AccessionPrimary (citable) accession number: O15355
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: June 16, 2009
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents