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Protein

Protein phosphatase 1G

Gene

PPM1G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Manganese 1By similarity1
Metal bindingi60Manganese 2By similarity1
Metal bindingi61Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi441Manganese 2By similarity1
Metal bindingi496Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

  • cell cycle arrest Source: ProtInc
  • peptidyl-threonine dephosphorylation Source: UniProtKB
  • protein dephosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS03855-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1G (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 1C
Protein phosphatase 2C isoform gamma
Short name:
PP2C-gamma
Protein phosphatase magnesium-dependent 1 gamma
Gene namesi
Name:PPM1G
Synonyms:PPM1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:9278. PPM1G.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • membrane Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5496.
OpenTargetsiENSG00000115241.
PharmGKBiPA33606.

Chemistry databases

ChEMBLiCHEMBL3351199.

Polymorphism and mutation databases

BioMutaiPPM1G.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000577502 – 546Protein phosphatase 1GAdd BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine2 Publications1
Modified residuei22Omega-N-methylarginineCombined sources1
Modified residuei122PhosphothreonineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei383N6-acetyllysineCombined sources1
Modified residuei527PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Myristate, Phosphoprotein

Proteomic databases

EPDiO15355.
PaxDbiO15355.
PeptideAtlasiO15355.
PRIDEiO15355.

PTM databases

DEPODiO15355.
iPTMnetiO15355.
PhosphoSitePlusiO15355.
SwissPalmiO15355.

Expressioni

Tissue specificityi

Widely expressed. Most abundant in testis, skeletal muscle, and heart.

Gene expression databases

BgeeiENSG00000115241.
CleanExiHS_PPM1G.
ExpressionAtlasiO15355. baseline and differential.
GenevisibleiO15355. HS.

Organism-specific databases

HPAiHPA035530.
HPA035531.

Interactioni

Subunit structurei

Interacts with NOL3; may dephosphorylate NOL3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
tatP046083EBI-725702,EBI-6164389From a different organism.
TERF1P542742EBI-725702,EBI-710997

Protein-protein interaction databases

BioGridi111491. 92 interactors.
DIPiDIP-29404N.
IntActiO15355. 30 interactors.
MINTiMINT-5003792.
STRINGi9606.ENSP00000264714.

Chemistry databases

BindingDBiO15355.

Structurei

3D structure databases

ProteinModelPortaliO15355.
SMRiO15355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 505PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST480

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi258 – 322Glu-richPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0699. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00860000133868.
HOGENOMiHOG000233896.
HOVERGENiHBG053647.
InParanoidiO15355.
KOiK17499.
OMAiHNCILNF.
OrthoDBiEOG091G0D0W.
PhylomeDBiO15355.
TreeFamiTF354280.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 2 hits.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD
60 70 80 90 100
SETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA
110 120 130 140 150
IDAKLTTEEV IKELAQIAGR PTEDEDEKEK VADEDDVDNE EAALLHEEAT
160 170 180 190 200
MTIEELLTRY GQNCHKGPPH SKSGGGTGEE PGSQGLNGEA GPEDSTRETP
210 220 230 240 250
SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS CSSASDKLPR
260 270 280 290 300
VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE
310 320 330 340 350
AEEDDEEEEE EMMVPGMEGK EEPGSDSGTT AVVALIRGKQ LIVANAGDSR
360 370 380 390 400
CVVSEAGKAL DMSYDHKPED EVELARIKNA GGKVTMDGRV NGGLNLSRAI
410 420 430 440 450
GDHFYKRNKN LPPEEQMISA LPDIKVLTLT DDHEFMVIAC DGIWNVMSSQ
460 470 480 490 500
EVVDFIQSKI SQRDENGELR LLSSIVEELL DQCLAPDTSG DGTGCDNMTC
510 520 530 540
IIICFKPRNT AELQPESGKR KLEEVLSTEG AEENGNSDKK KKAKRD
Length:546
Mass (Da):59,272
Last modified:January 1, 1998 - v1
Checksum:i084C16F8252330D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13936 mRNA. Translation: CAA74245.1.
BC022061 mRNA. Translation: AAH22061.1.
BC000057 mRNA. Translation: AAH00057.1.
CCDSiCCDS1752.1.
RefSeqiNP_817092.1. NM_177983.2.
UniGeneiHs.643951.

Genome annotation databases

EnsembliENST00000344034; ENSP00000342778; ENSG00000115241.
GeneIDi5496.
KEGGihsa:5496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13936 mRNA. Translation: CAA74245.1.
BC022061 mRNA. Translation: AAH22061.1.
BC000057 mRNA. Translation: AAH00057.1.
CCDSiCCDS1752.1.
RefSeqiNP_817092.1. NM_177983.2.
UniGeneiHs.643951.

3D structure databases

ProteinModelPortaliO15355.
SMRiO15355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111491. 92 interactors.
DIPiDIP-29404N.
IntActiO15355. 30 interactors.
MINTiMINT-5003792.
STRINGi9606.ENSP00000264714.

Chemistry databases

BindingDBiO15355.
ChEMBLiCHEMBL3351199.

PTM databases

DEPODiO15355.
iPTMnetiO15355.
PhosphoSitePlusiO15355.
SwissPalmiO15355.

Polymorphism and mutation databases

BioMutaiPPM1G.

Proteomic databases

EPDiO15355.
PaxDbiO15355.
PeptideAtlasiO15355.
PRIDEiO15355.

Protocols and materials databases

DNASUi5496.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344034; ENSP00000342778; ENSG00000115241.
GeneIDi5496.
KEGGihsa:5496.

Organism-specific databases

CTDi5496.
DisGeNETi5496.
GeneCardsiPPM1G.
HGNCiHGNC:9278. PPM1G.
HPAiHPA035530.
HPA035531.
MIMi605119. gene.
neXtProtiNX_O15355.
OpenTargetsiENSG00000115241.
PharmGKBiPA33606.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0699. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00860000133868.
HOGENOMiHOG000233896.
HOVERGENiHBG053647.
InParanoidiO15355.
KOiK17499.
OMAiHNCILNF.
OrthoDBiEOG091G0D0W.
PhylomeDBiO15355.
TreeFamiTF354280.

Enzyme and pathway databases

BioCyciZFISH:HS03855-MONOMER.

Miscellaneous databases

ChiTaRSiPPM1G. human.
GeneWikiiPPM1G.
GenomeRNAii5496.
PROiO15355.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115241.
CleanExiHS_PPM1G.
ExpressionAtlasiO15355. baseline and differential.
GenevisibleiO15355. HS.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 2 hits.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPM1G_HUMAN
AccessioniPrimary (citable) accession number: O15355
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 165 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.