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O15355

- PPM1G_HUMAN

UniProt

O15355 - PPM1G_HUMAN

Protein

Protein phosphatase 1G

Gene

PPM1G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Manganese 1By similarity
    Metal bindingi60 – 601Manganese 2By similarity
    Metal bindingi61 – 611Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi441 – 4411Manganese 2By similarity
    Metal bindingi496 – 4961Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein serine/threonine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. cell cycle arrest Source: ProtInc
    2. peptidyl-threonine dephosphorylation Source: UniProtKB
    3. protein dephosphorylation Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1G (EC:3.1.3.16)
    Alternative name(s):
    Protein phosphatase 1C
    Protein phosphatase 2C isoform gamma
    Short name:
    PP2C-gamma
    Protein phosphatase magnesium-dependent 1 gamma
    Gene namesi
    Name:PPM1G
    Synonyms:PPM1C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:9278. PPM1G.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33606.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 546546Protein phosphatase 1GPRO_0000057750Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei183 – 1831Phosphoserine1 Publication
    Modified residuei383 – 3831N6-acetyllysine1 Publication
    Modified residuei527 – 5271Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO15355.
    PaxDbiO15355.
    PeptideAtlasiO15355.
    PRIDEiO15355.

    PTM databases

    PhosphoSiteiO15355.

    Expressioni

    Tissue specificityi

    Widely expressed. Most abundant in testis, skeletal muscle, and heart.

    Gene expression databases

    ArrayExpressiO15355.
    BgeeiO15355.
    CleanExiHS_PPM1G.
    GenevestigatoriO15355.

    Organism-specific databases

    HPAiHPA035530.
    HPA035531.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    tatP046083EBI-725702,EBI-6164389From a different organism.

    Protein-protein interaction databases

    BioGridi111491. 56 interactions.
    DIPiDIP-29404N.
    IntActiO15355. 14 interactions.
    MINTiMINT-5003792.
    STRINGi9606.ENSP00000264714.

    Structurei

    3D structure databases

    ProteinModelPortaliO15355.
    SMRiO15355. Positions 1-126, 274-506.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi258 – 32669Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi266 – 2727Poly-Glu
    Compositional biasi306 – 3116Poly-Glu
    Compositional biasi539 – 5446Poly-Lys

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233896.
    HOVERGENiHBG053647.
    InParanoidiO15355.
    KOiK17499.
    OMAiMISAMPD.
    OrthoDBiEOG7034GD.
    PhylomeDBiO15355.
    TreeFamiTF354280.

    Family and domain databases

    Gene3Di3.60.40.10. 2 hits.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 2 hits.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 2 hits.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O15355-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD    50
    SETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA 100
    IDAKLTTEEV IKELAQIAGR PTEDEDEKEK VADEDDVDNE EAALLHEEAT 150
    MTIEELLTRY GQNCHKGPPH SKSGGGTGEE PGSQGLNGEA GPEDSTRETP 200
    SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS CSSASDKLPR 250
    VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE 300
    AEEDDEEEEE EMMVPGMEGK EEPGSDSGTT AVVALIRGKQ LIVANAGDSR 350
    CVVSEAGKAL DMSYDHKPED EVELARIKNA GGKVTMDGRV NGGLNLSRAI 400
    GDHFYKRNKN LPPEEQMISA LPDIKVLTLT DDHEFMVIAC DGIWNVMSSQ 450
    EVVDFIQSKI SQRDENGELR LLSSIVEELL DQCLAPDTSG DGTGCDNMTC 500
    IIICFKPRNT AELQPESGKR KLEEVLSTEG AEENGNSDKK KKAKRD 546
    Length:546
    Mass (Da):59,272
    Last modified:January 1, 1998 - v1
    Checksum:i084C16F8252330D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13936 mRNA. Translation: CAA74245.1.
    BC022061 mRNA. Translation: AAH22061.1.
    BC000057 mRNA. Translation: AAH00057.1.
    CCDSiCCDS1752.1.
    RefSeqiNP_817092.1. NM_177983.2.
    UniGeneiHs.643951.

    Genome annotation databases

    EnsembliENST00000344034; ENSP00000342778; ENSG00000115241.
    GeneIDi5496.
    KEGGihsa:5496.
    UCSCiuc002rkl.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13936 mRNA. Translation: CAA74245.1 .
    BC022061 mRNA. Translation: AAH22061.1 .
    BC000057 mRNA. Translation: AAH00057.1 .
    CCDSi CCDS1752.1.
    RefSeqi NP_817092.1. NM_177983.2.
    UniGenei Hs.643951.

    3D structure databases

    ProteinModelPortali O15355.
    SMRi O15355. Positions 1-126, 274-506.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111491. 56 interactions.
    DIPi DIP-29404N.
    IntActi O15355. 14 interactions.
    MINTi MINT-5003792.
    STRINGi 9606.ENSP00000264714.

    PTM databases

    PhosphoSitei O15355.

    Proteomic databases

    MaxQBi O15355.
    PaxDbi O15355.
    PeptideAtlasi O15355.
    PRIDEi O15355.

    Protocols and materials databases

    DNASUi 5496.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344034 ; ENSP00000342778 ; ENSG00000115241 .
    GeneIDi 5496.
    KEGGi hsa:5496.
    UCSCi uc002rkl.4. human.

    Organism-specific databases

    CTDi 5496.
    GeneCardsi GC02M027604.
    HGNCi HGNC:9278. PPM1G.
    HPAi HPA035530.
    HPA035531.
    MIMi 605119. gene.
    neXtProti NX_O15355.
    PharmGKBi PA33606.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233896.
    HOVERGENi HBG053647.
    InParanoidi O15355.
    KOi K17499.
    OMAi MISAMPD.
    OrthoDBi EOG7034GD.
    PhylomeDBi O15355.
    TreeFami TF354280.

    Miscellaneous databases

    ChiTaRSi PPM1G. human.
    GeneWikii PPM1G.
    GenomeRNAii 5496.
    NextBioi 21262.
    PROi O15355.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15355.
    Bgeei O15355.
    CleanExi HS_PPM1G.
    Genevestigatori O15355.

    Family and domain databases

    Gene3Di 3.60.40.10. 2 hits.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 2 hits.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 2 hits.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PP2C gamma: a human protein phosphatase with a unique acidic domain."
      Travis S.M., Welsh M.J.
      FEBS Lett. 412:415-419(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta and Skin.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-383, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-527, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPPM1G_HUMAN
    AccessioniPrimary (citable) accession number: O15355
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3