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O15355

- PPM1G_HUMAN

UniProt

O15355 - PPM1G_HUMAN

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Protein
Protein phosphatase 1G
Gene
PPM1G, PPM1C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Manganese 1 By similarity
Metal bindingi60 – 601Manganese 2 By similarity
Metal bindingi61 – 611Manganese 1; via carbonyl oxygen By similarity
Metal bindingi441 – 4411Manganese 2 By similarity
Metal bindingi496 – 4961Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. cell cycle arrest Source: ProtInc
  2. peptidyl-threonine dephosphorylation Source: UniProtKB
  3. protein dephosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1G (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 1C
Protein phosphatase 2C isoform gamma
Short name:
PP2C-gamma
Protein phosphatase magnesium-dependent 1 gamma
Gene namesi
Name:PPM1G
Synonyms:PPM1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:9278. PPM1G.

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33606.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 546546Protein phosphatase 1G
PRO_0000057750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831Phosphoserine1 Publication
Modified residuei383 – 3831N6-acetyllysine1 Publication
Modified residuei527 – 5271Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO15355.
PaxDbiO15355.
PeptideAtlasiO15355.
PRIDEiO15355.

PTM databases

PhosphoSiteiO15355.

Expressioni

Tissue specificityi

Widely expressed. Most abundant in testis, skeletal muscle, and heart.

Gene expression databases

ArrayExpressiO15355.
BgeeiO15355.
CleanExiHS_PPM1G.
GenevestigatoriO15355.

Organism-specific databases

HPAiHPA035530.
HPA035531.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
tatP046083EBI-725702,EBI-6164389From a different organism.

Protein-protein interaction databases

BioGridi111491. 56 interactions.
DIPiDIP-29404N.
IntActiO15355. 14 interactions.
MINTiMINT-5003792.
STRINGi9606.ENSP00000264714.

Structurei

3D structure databases

ProteinModelPortaliO15355.
SMRiO15355. Positions 1-126, 274-506.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi258 – 32669Asp/Glu-rich (acidic)
Add
BLAST
Compositional biasi266 – 2727Poly-Glu
Compositional biasi306 – 3116Poly-Glu
Compositional biasi539 – 5446Poly-Lys

Sequence similaritiesi

Belongs to the PP2C family.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
HOVERGENiHBG053647.
InParanoidiO15355.
KOiK17499.
OMAiMISAMPD.
OrthoDBiEOG7034GD.
PhylomeDBiO15355.
TreeFamiTF354280.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15355-1 [UniParc]FASTAAdd to Basket

« Hide

MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD    50
SETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA 100
IDAKLTTEEV IKELAQIAGR PTEDEDEKEK VADEDDVDNE EAALLHEEAT 150
MTIEELLTRY GQNCHKGPPH SKSGGGTGEE PGSQGLNGEA GPEDSTRETP 200
SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS CSSASDKLPR 250
VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE 300
AEEDDEEEEE EMMVPGMEGK EEPGSDSGTT AVVALIRGKQ LIVANAGDSR 350
CVVSEAGKAL DMSYDHKPED EVELARIKNA GGKVTMDGRV NGGLNLSRAI 400
GDHFYKRNKN LPPEEQMISA LPDIKVLTLT DDHEFMVIAC DGIWNVMSSQ 450
EVVDFIQSKI SQRDENGELR LLSSIVEELL DQCLAPDTSG DGTGCDNMTC 500
IIICFKPRNT AELQPESGKR KLEEVLSTEG AEENGNSDKK KKAKRD 546
Length:546
Mass (Da):59,272
Last modified:January 1, 1998 - v1
Checksum:i084C16F8252330D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13936 mRNA. Translation: CAA74245.1.
BC022061 mRNA. Translation: AAH22061.1.
BC000057 mRNA. Translation: AAH00057.1.
CCDSiCCDS1752.1.
RefSeqiNP_817092.1. NM_177983.2.
UniGeneiHs.643951.

Genome annotation databases

EnsembliENST00000344034; ENSP00000342778; ENSG00000115241.
ENST00000350803; ENSP00000264714; ENSG00000115241.
GeneIDi5496.
KEGGihsa:5496.
UCSCiuc002rkl.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13936 mRNA. Translation: CAA74245.1 .
BC022061 mRNA. Translation: AAH22061.1 .
BC000057 mRNA. Translation: AAH00057.1 .
CCDSi CCDS1752.1.
RefSeqi NP_817092.1. NM_177983.2.
UniGenei Hs.643951.

3D structure databases

ProteinModelPortali O15355.
SMRi O15355. Positions 1-126, 274-506.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111491. 56 interactions.
DIPi DIP-29404N.
IntActi O15355. 14 interactions.
MINTi MINT-5003792.
STRINGi 9606.ENSP00000264714.

PTM databases

PhosphoSitei O15355.

Proteomic databases

MaxQBi O15355.
PaxDbi O15355.
PeptideAtlasi O15355.
PRIDEi O15355.

Protocols and materials databases

DNASUi 5496.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344034 ; ENSP00000342778 ; ENSG00000115241 .
ENST00000350803 ; ENSP00000264714 ; ENSG00000115241 .
GeneIDi 5496.
KEGGi hsa:5496.
UCSCi uc002rkl.4. human.

Organism-specific databases

CTDi 5496.
GeneCardsi GC02M027604.
HGNCi HGNC:9278. PPM1G.
HPAi HPA035530.
HPA035531.
MIMi 605119. gene.
neXtProti NX_O15355.
PharmGKBi PA33606.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233896.
HOVERGENi HBG053647.
InParanoidi O15355.
KOi K17499.
OMAi MISAMPD.
OrthoDBi EOG7034GD.
PhylomeDBi O15355.
TreeFami TF354280.

Miscellaneous databases

ChiTaRSi PPM1G. human.
GeneWikii PPM1G.
GenomeRNAii 5496.
NextBioi 21262.
PROi O15355.
SOURCEi Search...

Gene expression databases

ArrayExpressi O15355.
Bgeei O15355.
CleanExi HS_PPM1G.
Genevestigatori O15355.

Family and domain databases

Gene3Di 3.60.40.10. 2 hits.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 2 hits.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 2 hits.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PP2C gamma: a human protein phosphatase with a unique acidic domain."
    Travis S.M., Welsh M.J.
    FEBS Lett. 412:415-419(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Skin.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-383, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-527, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPPM1G_HUMAN
AccessioniPrimary (citable) accession number: O15355
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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