SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O15354

- GPR37_HUMAN

UniProt

O15354 - GPR37_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Prosaposin receptor GPR37
Gene
GPR37
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.3 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37
Alternative name(s):
Endothelin B receptor-like protein 1
Short name:
ETBR-LP-1
G-protein coupled receptor 37
Parkin-associated endothelin receptor-like receptor
Short name:
PAELR
Gene namesi
Name:GPR37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:4494. GPR37.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 265239Extracellular Reviewed prediction
Add
BLAST
Transmembranei266 – 28621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini287 – 29913Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei300 – 32021Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini321 – 33515Extracellular Reviewed prediction
Add
BLAST
Transmembranei336 – 35621Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini357 – 37923Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei380 – 40021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini401 – 44343Extracellular Reviewed prediction
Add
BLAST
Transmembranei444 – 46421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini465 – 49329Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei494 – 51421Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini515 – 53117Extracellular Reviewed prediction
Add
BLAST
Transmembranei532 – 55221Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini553 – 61361Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: ProtInc
  3. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 613587Prosaposin receptor GPR37
PRO_0000012799Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi239 – 2391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi334 ↔ 419 By similarity

Post-translational modificationi

Ubiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiO15354.
PRIDEiO15354.

PTM databases

PhosphoSiteiO15354.

Expressioni

Tissue specificityi

Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ).1 Publication

Gene expression databases

ArrayExpressiO15354.
BgeeiO15354.
CleanExiHS_GPR37.
GenevestigatoriO15354.

Interactioni

Subunit structurei

Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG.3 Publications

Protein-protein interaction databases

BioGridi109119. 19 interactions.
STRINGi9606.ENSP00000306449.

Structurei

3D structure databases

ProteinModelPortaliO15354.
SMRiO15354. Positions 240-565.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi563 – 5686Poly-Cys

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291459.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiO15354.
KOiK04243.
OMAiIQRRSRD.
OrthoDBiEOG79SDX9.
PhylomeDBiO15354.
TreeFamiTF331292.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15354-1 [UniParc]FASTAAdd to Basket

« Hide

MRAPGALLAR MSRLLLLLLL KVSASSALGV APASRNETCL GESCAPTVIQ    50
RRGRDAWGPG NSARDVLRAR APREEQGAAF LAGPSWDLPA APGRDPAAGR 100
GAEASAAGPP GPPTRPPGPW RWKGARGQEP SETLGRGNPT ALQLFLQISE 150
EEEKGPRGAG ISGRSQEQSV KTVPGASDLF YWPRRAGKLQ GSHHKPLSKT 200
ANGLAGHEGW TIALPGRALA QNGSLGEGIH EPGGPRRGNS TNRRVRLKNP 250
FYPLTQESYG AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL 300
ANLAFWDFLI IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF 350
TLCALCIDRF RAATNVQMYY EMIENCSSTT AKLAVIWVGA LLLALPEVVL 400
RQLSKEDLGF SGRAPAERCI IKISPDLPDT IYVLALTYDS ARLWWYFGCY 450
FCLPTLFTIT CSLVTARKIR KAEKACTRGN KRQIQLESQM NCTVVALTIL 500
YGFCIIPENI CNIVTAYMAT GVSQQTMDLL NIISQFLLFF KSCVTPVLLF 550
CLCKPFSRAF MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR 600
REMSTFASVG THC 613
Length:613
Mass (Da):67,114
Last modified:January 1, 1999 - v2
Checksum:i5A1AB269ED63E765
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931G → D in AAC51281. 1 Publication
Sequence conflicti106 – 1061A → T in AAC51281. 1 Publication
Sequence conflicti118 – 1181G → V in AAC51281. 1 Publication
Sequence conflicti160 – 1601G → V in AAC51281. 1 Publication
Sequence conflicti182 – 1821W → C in AAC51281. 1 Publication
Sequence conflicti231 – 2311E → D in AAC51281. 1 Publication
Sequence conflicti284 – 2841C → S in AAB70008. 1 Publication
Sequence conflicti304 – 3041A → V in AAC51281. 1 Publication
Sequence conflicti329 – 3291L → V in AAC51281. 1 Publication
Sequence conflicti503 – 5042FC → LG in AAC51281. 1 Publication
Sequence conflicti598 – 5981T → A in AAC51281. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12476, Y12477 Genomic DNA. Translation: CAA73080.1.
AF017262 mRNA. Translation: AAB70008.1.
U87460 mRNA. Translation: AAC51281.1.
AF502281 mRNA. Translation: AAM18625.2.
AC004925 Genomic DNA. Translation: AAD08853.1.
CH236947 Genomic DNA. Translation: EAL24325.1.
CH471070 Genomic DNA. Translation: EAW83613.1.
BC040007 mRNA. Translation: AAH40007.1.
CCDSiCCDS5792.1.
PIRiJC5501.
RefSeqiNP_005293.1. NM_005302.3.
UniGeneiHs.406094.
Hs.731392.

Genome annotation databases

EnsembliENST00000303921; ENSP00000306449; ENSG00000170775.
GeneIDi2861.
KEGGihsa:2861.
UCSCiuc003vli.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12476 , Y12477 Genomic DNA. Translation: CAA73080.1 .
AF017262 mRNA. Translation: AAB70008.1 .
U87460 mRNA. Translation: AAC51281.1 .
AF502281 mRNA. Translation: AAM18625.2 .
AC004925 Genomic DNA. Translation: AAD08853.1 .
CH236947 Genomic DNA. Translation: EAL24325.1 .
CH471070 Genomic DNA. Translation: EAW83613.1 .
BC040007 mRNA. Translation: AAH40007.1 .
CCDSi CCDS5792.1.
PIRi JC5501.
RefSeqi NP_005293.1. NM_005302.3.
UniGenei Hs.406094.
Hs.731392.

3D structure databases

ProteinModelPortali O15354.
SMRi O15354. Positions 240-565.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109119. 19 interactions.
STRINGi 9606.ENSP00000306449.

Chemistry

GuidetoPHARMACOLOGYi 103.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O15354.

Proteomic databases

PaxDbi O15354.
PRIDEi O15354.

Protocols and materials databases

DNASUi 2861.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303921 ; ENSP00000306449 ; ENSG00000170775 .
GeneIDi 2861.
KEGGi hsa:2861.
UCSCi uc003vli.4. human.

Organism-specific databases

CTDi 2861.
GeneCardsi GC07M124386.
HGNCi HGNC:4494. GPR37.
MIMi 602583. gene.
neXtProti NX_O15354.
PharmGKBi PA28882.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG291459.
HOGENOMi HOG000252922.
HOVERGENi HBG051808.
InParanoidi O15354.
KOi K04243.
OMAi IQRRSRD.
OrthoDBi EOG79SDX9.
PhylomeDBi O15354.
TreeFami TF331292.

Miscellaneous databases

GeneWikii GPR37.
GenomeRNAii 2861.
NextBioi 11281.
PROi O15354.
SOURCEi Search...

Gene expression databases

ArrayExpressi O15354.
Bgeei O15354.
CleanExi HS_GPR37.
Genevestigatori O15354.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library."
    Marazziti D., Golini E., Gallo A., Lombardi M.S., Matteoni R., Tocchini-Valentini G.P.
    Genomics 45:68-77(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  2. "A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system."
    Donohue P.J., Shapira H., Mantey S.A., Hampton L.L., Jensen R.T., Battey J.F.
    Brain Res. Mol. Brain Res. 54:152-160(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  3. "A novel endothelin receptor type-B-like gene enriched in the brain."
    Zeng Z., Su K., Kyaw H., Li Y.
    Biochem. Biophys. Res. Commun. 233:559-567(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin."
    Imai Y., Soda M., Inoue H., Hattori N., Mizuno Y., Takahashi R.
    Cell 105:891-902(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH PARK2.
    Tissue: Brain.
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  9. "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity."
    Imai Y., Soda M., Hatakeyama S., Akagi T., Hashikawa T., Nakayama K., Takahashi R.
    Mol. Cell 10:55-67(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PARK2; STUB1 AND HSP70.
  10. "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death."
    Imai Y., Soda M., Murakami T., Shoji M., Abe K., Takahashi R.
    J. Biol. Chem. 278:51901-51910(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PACRG.
  11. "A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin."
    Omura T., Kaneko M., Okuma Y., Orba Y., Nagashima K., Takahashi R., Fujitani N., Matsumura S., Hata A., Kubota K., Murahashi K., Uehara T., Nomura Y.
    J. Neurochem. 99:1456-1469(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, SUBCELLULAR LOCATION.
  12. "GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin."
    Meyer R.C., Giddens M.M., Schaefer S.A., Hall R.A.
    Proc. Natl. Acad. Sci. U.S.A. 110:9529-9534(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGPR37_HUMAN
AccessioniPrimary (citable) accession number: O15354
Secondary accession number(s): A4D0Y6
, O00348, O14768, Q8TD39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1999
Last modified: September 3, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi