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Protein

Prosaposin receptor GPR37

Gene

GPR37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.3 Publications

GO - Molecular functioni

  • G-protein coupled peptide receptor activity Source: ParkinsonsUK-UCL
  • G-protein coupled receptor activity Source: ProtInc
  • heat shock protein binding Source: ParkinsonsUK-UCL
  • Hsp70 protein binding Source: ParkinsonsUK-UCL
  • peptide binding Source: ParkinsonsUK-UCL
  • prosaposin receptor activity Source: ParkinsonsUK-UCL
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170775-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
SIGNORiO15354.

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37
Alternative name(s):
Endothelin B receptor-like protein 1
Short name:
ETBR-LP-1
G-protein coupled receptor 37
Parkin-associated endothelin receptor-like receptor
Short name:
PAELR
Gene namesi
Name:GPR37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:4494. GPR37.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 265ExtracellularSequence analysisAdd BLAST239
Transmembranei266 – 286Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini287 – 299CytoplasmicSequence analysisAdd BLAST13
Transmembranei300 – 320Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini321 – 335ExtracellularSequence analysisAdd BLAST15
Transmembranei336 – 356Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini357 – 379CytoplasmicSequence analysisAdd BLAST23
Transmembranei380 – 400Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini401 – 443ExtracellularSequence analysisAdd BLAST43
Transmembranei444 – 464Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini465 – 493CytoplasmicSequence analysisAdd BLAST29
Transmembranei494 – 514Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini515 – 531ExtracellularSequence analysisAdd BLAST17
Transmembranei532 – 552Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini553 – 613CytoplasmicSequence analysisAdd BLAST61

GO - Cellular componenti

  • endoplasmic reticulum Source: ParkinsonsUK-UCL
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: ParkinsonsUK-UCL
  • receptor complex Source: MGI
  • ubiquitin ligase complex Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2861.
OpenTargetsiENSG00000170775.
PharmGKBiPA28882.

Chemistry databases

GuidetoPHARMACOLOGYi103.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001279927 – 613Prosaposin receptor GPR37Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Glycosylationi222N-linked (GlcNAc...)Sequence analysis1
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi334 ↔ 419PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiO15354.
PaxDbiO15354.
PeptideAtlasiO15354.
PRIDEiO15354.

PTM databases

iPTMnetiO15354.
PhosphoSitePlusiO15354.

Expressioni

Tissue specificityi

Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ).1 Publication

Gene expression databases

BgeeiENSG00000170775.
CleanExiHS_GPR37.
GenevisibleiO15354. HS.

Organism-specific databases

HPAiHPA068009.

Interactioni

Subunit structurei

Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG.3 Publications

GO - Molecular functioni

  • heat shock protein binding Source: ParkinsonsUK-UCL
  • Hsp70 protein binding Source: ParkinsonsUK-UCL
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi109119. 26 interactors.
DIPiDIP-60954N.
STRINGi9606.ENSP00000306449.

Structurei

3D structure databases

ProteinModelPortaliO15354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi563 – 568Poly-Cys6

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiO15354.
KOiK04243.
OMAiIQRRSRD.
OrthoDBiEOG091G04SU.
PhylomeDBiO15354.
TreeFamiTF331292.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15354-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAPGALLAR MSRLLLLLLL KVSASSALGV APASRNETCL GESCAPTVIQ
60 70 80 90 100
RRGRDAWGPG NSARDVLRAR APREEQGAAF LAGPSWDLPA APGRDPAAGR
110 120 130 140 150
GAEASAAGPP GPPTRPPGPW RWKGARGQEP SETLGRGNPT ALQLFLQISE
160 170 180 190 200
EEEKGPRGAG ISGRSQEQSV KTVPGASDLF YWPRRAGKLQ GSHHKPLSKT
210 220 230 240 250
ANGLAGHEGW TIALPGRALA QNGSLGEGIH EPGGPRRGNS TNRRVRLKNP
260 270 280 290 300
FYPLTQESYG AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL
310 320 330 340 350
ANLAFWDFLI IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF
360 370 380 390 400
TLCALCIDRF RAATNVQMYY EMIENCSSTT AKLAVIWVGA LLLALPEVVL
410 420 430 440 450
RQLSKEDLGF SGRAPAERCI IKISPDLPDT IYVLALTYDS ARLWWYFGCY
460 470 480 490 500
FCLPTLFTIT CSLVTARKIR KAEKACTRGN KRQIQLESQM NCTVVALTIL
510 520 530 540 550
YGFCIIPENI CNIVTAYMAT GVSQQTMDLL NIISQFLLFF KSCVTPVLLF
560 570 580 590 600
CLCKPFSRAF MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR
610
REMSTFASVG THC
Length:613
Mass (Da):67,114
Last modified:January 1, 1999 - v2
Checksum:i5A1AB269ED63E765
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93G → D in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti106A → T in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti118G → V in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti160G → V in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti182W → C in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti231E → D in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti284C → S in AAB70008 (PubMed:9526070).Curated1
Sequence conflicti304A → V in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti329L → V in AAC51281 (PubMed:9144577).Curated1
Sequence conflicti503 – 504FC → LG in AAC51281 (PubMed:9144577).Curated2
Sequence conflicti598T → A in AAC51281 (PubMed:9144577).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12476, Y12477 Genomic DNA. Translation: CAA73080.1.
AF017262 mRNA. Translation: AAB70008.1.
U87460 mRNA. Translation: AAC51281.1.
AF502281 mRNA. Translation: AAM18625.2.
AC004925 Genomic DNA. Translation: AAD08853.1.
CH236947 Genomic DNA. Translation: EAL24325.1.
CH471070 Genomic DNA. Translation: EAW83613.1.
BC040007 mRNA. Translation: AAH40007.1.
CCDSiCCDS5792.1.
PIRiJC5501.
RefSeqiNP_005293.1. NM_005302.3.
UniGeneiHs.406094.
Hs.731392.

Genome annotation databases

EnsembliENST00000303921; ENSP00000306449; ENSG00000170775.
GeneIDi2861.
KEGGihsa:2861.
UCSCiuc003vli.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12476, Y12477 Genomic DNA. Translation: CAA73080.1.
AF017262 mRNA. Translation: AAB70008.1.
U87460 mRNA. Translation: AAC51281.1.
AF502281 mRNA. Translation: AAM18625.2.
AC004925 Genomic DNA. Translation: AAD08853.1.
CH236947 Genomic DNA. Translation: EAL24325.1.
CH471070 Genomic DNA. Translation: EAW83613.1.
BC040007 mRNA. Translation: AAH40007.1.
CCDSiCCDS5792.1.
PIRiJC5501.
RefSeqiNP_005293.1. NM_005302.3.
UniGeneiHs.406094.
Hs.731392.

3D structure databases

ProteinModelPortaliO15354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109119. 26 interactors.
DIPiDIP-60954N.
STRINGi9606.ENSP00000306449.

Chemistry databases

GuidetoPHARMACOLOGYi103.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO15354.
PhosphoSitePlusiO15354.

Proteomic databases

EPDiO15354.
PaxDbiO15354.
PeptideAtlasiO15354.
PRIDEiO15354.

Protocols and materials databases

DNASUi2861.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303921; ENSP00000306449; ENSG00000170775.
GeneIDi2861.
KEGGihsa:2861.
UCSCiuc003vli.5. human.

Organism-specific databases

CTDi2861.
DisGeNETi2861.
GeneCardsiGPR37.
HGNCiHGNC:4494. GPR37.
HPAiHPA068009.
MIMi602583. gene.
neXtProtiNX_O15354.
OpenTargetsiENSG00000170775.
PharmGKBiPA28882.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiO15354.
KOiK04243.
OMAiIQRRSRD.
OrthoDBiEOG091G04SU.
PhylomeDBiO15354.
TreeFamiTF331292.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170775-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
SIGNORiO15354.

Miscellaneous databases

GeneWikiiGPR37.
GenomeRNAii2861.
PROiO15354.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170775.
CleanExiHS_GPR37.
GenevisibleiO15354. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR37_HUMAN
AccessioniPrimary (citable) accession number: O15354
Secondary accession number(s): A4D0Y6
, O00348, O14768, Q8TD39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1999
Last modified: November 2, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.