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O15354

- GPR37_HUMAN

UniProt

O15354 - GPR37_HUMAN

Protein

Prosaposin receptor GPR37

Gene

GPR37

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (01 Jan 1999)
      Previous versions | rss
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    Functioni

    Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.3 Publications

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prosaposin receptor GPR37
    Alternative name(s):
    Endothelin B receptor-like protein 1
    Short name:
    ETBR-LP-1
    G-protein coupled receptor 37
    Parkin-associated endothelin receptor-like receptor
    Short name:
    PAELR
    Gene namesi
    Name:GPR37
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:4494. GPR37.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: ProtInc
    3. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28882.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 613587Prosaposin receptor GPR37PRO_0000012799Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi334 ↔ 419PROSITE-ProRule annotation

    Post-translational modificationi

    Ubiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiO15354.
    PRIDEiO15354.

    PTM databases

    PhosphoSiteiO15354.

    Expressioni

    Tissue specificityi

    Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ).1 Publication

    Gene expression databases

    ArrayExpressiO15354.
    BgeeiO15354.
    CleanExiHS_GPR37.
    GenevestigatoriO15354.

    Interactioni

    Subunit structurei

    Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG.3 Publications

    Protein-protein interaction databases

    BioGridi109119. 19 interactions.
    DIPiDIP-60954N.
    STRINGi9606.ENSP00000306449.

    Structurei

    3D structure databases

    ProteinModelPortaliO15354.
    SMRiO15354. Positions 240-565.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 265239ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini287 – 29913CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini321 – 33515ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini357 – 37923CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini401 – 44343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini465 – 49329CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini515 – 53117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini553 – 61361CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei266 – 28621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei300 – 32021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei336 – 35621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei444 – 46421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei494 – 51421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei532 – 55221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi563 – 5686Poly-Cys

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG291459.
    HOGENOMiHOG000252922.
    HOVERGENiHBG051808.
    InParanoidiO15354.
    KOiK04243.
    OMAiIQRRSRD.
    OrthoDBiEOG79SDX9.
    PhylomeDBiO15354.
    TreeFamiTF331292.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003909. GPR37_orph.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01421. GPR37ORPHANR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O15354-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAPGALLAR MSRLLLLLLL KVSASSALGV APASRNETCL GESCAPTVIQ    50
    RRGRDAWGPG NSARDVLRAR APREEQGAAF LAGPSWDLPA APGRDPAAGR 100
    GAEASAAGPP GPPTRPPGPW RWKGARGQEP SETLGRGNPT ALQLFLQISE 150
    EEEKGPRGAG ISGRSQEQSV KTVPGASDLF YWPRRAGKLQ GSHHKPLSKT 200
    ANGLAGHEGW TIALPGRALA QNGSLGEGIH EPGGPRRGNS TNRRVRLKNP 250
    FYPLTQESYG AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL 300
    ANLAFWDFLI IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF 350
    TLCALCIDRF RAATNVQMYY EMIENCSSTT AKLAVIWVGA LLLALPEVVL 400
    RQLSKEDLGF SGRAPAERCI IKISPDLPDT IYVLALTYDS ARLWWYFGCY 450
    FCLPTLFTIT CSLVTARKIR KAEKACTRGN KRQIQLESQM NCTVVALTIL 500
    YGFCIIPENI CNIVTAYMAT GVSQQTMDLL NIISQFLLFF KSCVTPVLLF 550
    CLCKPFSRAF MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR 600
    REMSTFASVG THC 613
    Length:613
    Mass (Da):67,114
    Last modified:January 1, 1999 - v2
    Checksum:i5A1AB269ED63E765
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti93 – 931G → D in AAC51281. (PubMed:9144577)Curated
    Sequence conflicti106 – 1061A → T in AAC51281. (PubMed:9144577)Curated
    Sequence conflicti118 – 1181G → V in AAC51281. (PubMed:9144577)Curated
    Sequence conflicti160 – 1601G → V in AAC51281. (PubMed:9144577)Curated
    Sequence conflicti182 – 1821W → C in AAC51281. (PubMed:9144577)Curated
    Sequence conflicti231 – 2311E → D in AAC51281. (PubMed:9144577)Curated
    Sequence conflicti284 – 2841C → S in AAB70008. (PubMed:9526070)Curated
    Sequence conflicti304 – 3041A → V in AAC51281. (PubMed:9144577)Curated
    Sequence conflicti329 – 3291L → V in AAC51281. (PubMed:9144577)Curated
    Sequence conflicti503 – 5042FC → LG in AAC51281. (PubMed:9144577)Curated
    Sequence conflicti598 – 5981T → A in AAC51281. (PubMed:9144577)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12476, Y12477 Genomic DNA. Translation: CAA73080.1.
    AF017262 mRNA. Translation: AAB70008.1.
    U87460 mRNA. Translation: AAC51281.1.
    AF502281 mRNA. Translation: AAM18625.2.
    AC004925 Genomic DNA. Translation: AAD08853.1.
    CH236947 Genomic DNA. Translation: EAL24325.1.
    CH471070 Genomic DNA. Translation: EAW83613.1.
    BC040007 mRNA. Translation: AAH40007.1.
    CCDSiCCDS5792.1.
    PIRiJC5501.
    RefSeqiNP_005293.1. NM_005302.3.
    UniGeneiHs.406094.
    Hs.731392.

    Genome annotation databases

    EnsembliENST00000303921; ENSP00000306449; ENSG00000170775.
    GeneIDi2861.
    KEGGihsa:2861.
    UCSCiuc003vli.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12476 , Y12477 Genomic DNA. Translation: CAA73080.1 .
    AF017262 mRNA. Translation: AAB70008.1 .
    U87460 mRNA. Translation: AAC51281.1 .
    AF502281 mRNA. Translation: AAM18625.2 .
    AC004925 Genomic DNA. Translation: AAD08853.1 .
    CH236947 Genomic DNA. Translation: EAL24325.1 .
    CH471070 Genomic DNA. Translation: EAW83613.1 .
    BC040007 mRNA. Translation: AAH40007.1 .
    CCDSi CCDS5792.1.
    PIRi JC5501.
    RefSeqi NP_005293.1. NM_005302.3.
    UniGenei Hs.406094.
    Hs.731392.

    3D structure databases

    ProteinModelPortali O15354.
    SMRi O15354. Positions 240-565.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109119. 19 interactions.
    DIPi DIP-60954N.
    STRINGi 9606.ENSP00000306449.

    Chemistry

    GuidetoPHARMACOLOGYi 103.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O15354.

    Proteomic databases

    PaxDbi O15354.
    PRIDEi O15354.

    Protocols and materials databases

    DNASUi 2861.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303921 ; ENSP00000306449 ; ENSG00000170775 .
    GeneIDi 2861.
    KEGGi hsa:2861.
    UCSCi uc003vli.4. human.

    Organism-specific databases

    CTDi 2861.
    GeneCardsi GC07M124386.
    HGNCi HGNC:4494. GPR37.
    MIMi 602583. gene.
    neXtProti NX_O15354.
    PharmGKBi PA28882.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG291459.
    HOGENOMi HOG000252922.
    HOVERGENi HBG051808.
    InParanoidi O15354.
    KOi K04243.
    OMAi IQRRSRD.
    OrthoDBi EOG79SDX9.
    PhylomeDBi O15354.
    TreeFami TF331292.

    Miscellaneous databases

    GeneWikii GPR37.
    GenomeRNAii 2861.
    NextBioi 11281.
    PROi O15354.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15354.
    Bgeei O15354.
    CleanExi HS_GPR37.
    Genevestigatori O15354.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003909. GPR37_orph.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01421. GPR37ORPHANR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library."
      Marazziti D., Golini E., Gallo A., Lombardi M.S., Matteoni R., Tocchini-Valentini G.P.
      Genomics 45:68-77(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Brain.
    2. "A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system."
      Donohue P.J., Shapira H., Mantey S.A., Hampton L.L., Jensen R.T., Battey J.F.
      Brain Res. Mol. Brain Res. 54:152-160(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Brain.
    3. "A novel endothelin receptor type-B-like gene enriched in the brain."
      Zeng Z., Su K., Kyaw H., Li Y.
      Biochem. Biophys. Res. Commun. 233:559-567(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin."
      Imai Y., Soda M., Inoue H., Hattori N., Mizuno Y., Takahashi R.
      Cell 105:891-902(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH PARK2.
      Tissue: Brain.
    5. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    9. "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity."
      Imai Y., Soda M., Hatakeyama S., Akagi T., Hashikawa T., Nakayama K., Takahashi R.
      Mol. Cell 10:55-67(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PARK2; STUB1 AND HSP70.
    10. "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death."
      Imai Y., Soda M., Murakami T., Shoji M., Abe K., Takahashi R.
      J. Biol. Chem. 278:51901-51910(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PACRG.
    11. "A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin."
      Omura T., Kaneko M., Okuma Y., Orba Y., Nagashima K., Takahashi R., Fujitani N., Matsumura S., Hata A., Kubota K., Murahashi K., Uehara T., Nomura Y.
      J. Neurochem. 99:1456-1469(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION, SUBCELLULAR LOCATION.
    12. "GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin."
      Meyer R.C., Giddens M.M., Schaefer S.A., Hall R.A.
      Proc. Natl. Acad. Sci. U.S.A. 110:9529-9534(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiGPR37_HUMAN
    AccessioniPrimary (citable) accession number: O15354
    Secondary accession number(s): A4D0Y6
    , O00348, O14768, Q8TD39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: January 1, 1999
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3