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Protein

E3 ubiquitin-protein ligase Midline-1

Gene

MID1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi119Zinc 11
Metal bindingi122Zinc 11
Metal bindingi134Zinc 21
Metal bindingi137Zinc 21
Metal bindingi142Zinc 11
Metal bindingi145Zinc 11
Metal bindingi150Zinc 21
Metal bindingi159Zinc 21

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri10 – 60RING-typePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri116 – 165B box-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri172 – 212B box-type 2PROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • ligase activity Source: UniProtKB-KW
  • microtubule binding Source: UniProtKB
  • phosphoprotein binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • interferon-gamma-mediated signaling pathway Source: Reactome
  • microtubule cytoskeleton organization Source: ProtInc
  • negative regulation of microtubule depolymerization Source: Ensembl
  • pattern specification process Source: ProtInc
  • positive regulation of stress-activated MAPK cascade Source: UniProtKB
  • protein localization to microtubule Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101871-MONOMER.
ReactomeiR-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase Midline-1 (EC:6.3.2.-)
Alternative name(s):
Midin
Putative transcription factor XPRF
RING finger protein 59
RING finger protein Midline-1
Tripartite motif-containing protein 18
Gene namesi
Name:MID1
Synonyms:FXY, RNF59, TRIM18, XPRF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:7095. MID1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • microtubule Source: UniProtKB
  • microtubule associated complex Source: ProtInc
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Involvement in diseasei

Opitz GBBB syndrome 1 (GBBB1)4 Publications
The disease is caused by mutations affecting the gene represented in this entry. MID1 mutations produce proteins with a decreased affinity for microtubules.
Disease descriptionA congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, cleft lip/palate, laryngotracheoesophageal abnormalities, imperforate anus, developmental delay and congenital heart defects.
See also OMIM:300000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013758266C → R in GBBB1. 1 Publication1
Natural variantiVAR_025495295L → P in GBBB1. 1 PublicationCorresponds to variant rs104894866dbSNPEnsembl.1
Natural variantiVAR_025496391 – 392LC → R in GBBB1. 1 Publication2
Natural variantiVAR_013759438Missing in GBBB1. 1 Publication1
Natural variantiVAR_013760534V → VFIDSGRHL in GBBB1. 1
Natural variantiVAR_013761536I → T in GBBB1. 1 Publication1
Natural variantiVAR_013762626L → P in GBBB1. 1 PublicationCorresponds to variant rs28934611dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi4281.
MalaCardsiMID1.
MIMi300000. phenotype.
OpenTargetsiENSG00000101871.
Orphaneti306597. X-linked Opitz G/BBB syndrome.
PharmGKBiPA30816.

Polymorphism and mutation databases

BioMutaiMID1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562271 – 667E3 ubiquitin-protein ligase Midline-1Add BLAST667

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on serine and threonine residues.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15344.
PaxDbiO15344.
PeptideAtlasiO15344.
PRIDEiO15344.

PTM databases

iPTMnetiO15344.
PhosphoSitePlusiO15344.

Expressioni

Tissue specificityi

In the fetus, highest expression found in kidney, followed by brain and lung. Expressed at low levels in fetal liver. In the adult, most abundant in heart, placenta and brain.

Inductioni

A retroviral element acts as an alternative tissue-specific promoter for this gene. The LTR of an HERV-E element enhances the expression in placenta and embryonic kidney.

Gene expression databases

BgeeiENSG00000101871.
CleanExiHS_MID1.
ExpressionAtlasiO15344. baseline and differential.
GenevisibleiO15344. HS.

Organism-specific databases

HPAiHPA003715.

Interactioni

Subunit structurei

Homodimer or heterodimer with MID2. Interacts with IGBP1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-2340316,EBI-2340316
BYSLQ138953EBI-2340316,EBI-358049
DYRK4Q9NR203EBI-2340316,EBI-3914009
EHHADHQ084265EBI-2340316,EBI-2339219
FKBP1AQ0VDC65EBI-2340316,EBI-10226858
FLJ13057Q53SE73EBI-2340316,EBI-10172181
GMCL1Q96IK54EBI-2340316,EBI-2548508
MEOX1P502213EBI-2340316,EBI-2864512
MID2Q9UJV3-27EBI-2340316,EBI-10172526
OTUB2Q96DC93EBI-2340316,EBI-746259
PKN1Q165123EBI-2340316,EBI-602382
TCEANCQ8N8B73EBI-2340316,EBI-954696
UBE2D1P516686EBI-2340316,EBI-743540
UBE2D2P628373EBI-2340316,EBI-347677
UBE2D3P610776EBI-2340316,EBI-348268
UBE2D4Q9Y2X83EBI-2340316,EBI-745527
UBE2E2Q96LR57EBI-2340316,EBI-2129763
UBE2E3Q969T46EBI-2340316,EBI-348496
UBE2L3P680363EBI-2340316,EBI-711173
UBTD1Q9HAC85EBI-2340316,EBI-745871

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • microtubule binding Source: UniProtKB
  • phosphoprotein binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110427. 73 interactors.
IntActiO15344. 37 interactors.
STRINGi9606.ENSP00000312678.

Structurei

Secondary structure

1667
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi112 – 114Combined sources3
Beta strandi124 – 126Combined sources3
Beta strandi132 – 134Combined sources3
Turni135 – 138Combined sources4
Beta strandi139 – 141Combined sources3
Helixi143 – 149Combined sources7
Beta strandi154 – 156Combined sources3
Beta strandi161 – 163Combined sources3
Beta strandi179 – 181Combined sources3
Beta strandi185 – 187Combined sources3
Turni188 – 191Combined sources4
Beta strandi192 – 194Combined sources3
Helixi196 – 200Combined sources5
Beta strandi205 – 207Combined sources3
Helixi325 – 346Combined sources22
Beta strandi352 – 355Combined sources4
Helixi356 – 374Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DQ5NMR-A168-214[»]
2FFWNMR-A87-164[»]
2JUNNMR-A114-214[»]
5IM8NMR-A320-379[»]
ProteinModelPortaliO15344.
SMRiO15344.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15344.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini320 – 379COSPROSITE-ProRule annotationAdd BLAST60
Domaini381 – 484Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST104
Domaini482 – 659B30.2/SPRYPROSITE-ProRule annotationAdd BLAST178

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili205 – 264Sequence analysisAdd BLAST60

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 2 B box-type zinc fingers.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 COS domain.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri10 – 60RING-typePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri116 – 165B box-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri172 – 212B box-type 2PROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITFU. Eukaryota.
ENOG410Z43Q. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000049193.
HOVERGENiHBG056432.
InParanoidiO15344.
KOiK08285.
OMAiRERAFDS.
OrthoDBiEOG091G02K9.
PhylomeDBiO15344.
TreeFamiTF333654.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR027727. MID1.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR24103:SF26. PTHR24103:SF26. 3 hits.
PfamiPF00041. fn3. 1 hit.
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15344-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METLESELTC PICLELFEDP LLLPCAHSLC FNCAHRILVS HCATNESVES
60 70 80 90 100
ITAFQCPTCR HVITLSQRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSET
110 120 130 140 150
RRERAFDANT MTSAEKVLCQ FCDQDPAQDA VKTCVTCEVS YCDECLKATH
160 170 180 190 200
PNKKPFTGHR LIEPIPDSHI RGLMCLEHED EKVNMYCVTD DQLICALCKL
210 220 230 240 250
VGRHRDHQVA ALSERYDKLK QNLESNLTNL IKRNTELETL LAKLIQTCQH
260 270 280 290 300
VEVNASRQEA KLTEECDLLI EIIQQRRQII GTKIKEGKVM RLRKLAQQIA
310 320 330 340 350
NCKQCIERSA SLISQAEHSL KENDHARFLQ TAKNITERVS MATASSQVLI
360 370 380 390 400
PEINLNDTFD TFALDFSREK KLLECLDYLT APNPPTIREE LCTASYDTIT
410 420 430 440 450
VHWTSDDEFS VVSYELQYTI FTGQANVVSL CNSADSWMIV PNIKQNHYTV
460 470 480 490 500
HGLQSGTKYI FMVKAINQAG SRSSEPGKLK TNSQPFKLDP KSAHRKLKVS
510 520 530 540 550
HDNLTVERDE SSSKKSHTPE RFTSQGSYGV AGNVFIDSGR HYWEVVISGS
560 570 580 590 600
TWYAIGLAYK SAPKHEWIGK NSASWALCRC NNNWVVRHNS KEIPIEPAPH
610 620 630 640 650
LRRVGILLDY DNGSIAFYDA LNSIHLYTFD VAFAQPVCPT FTVWNKCLTI
660
ITGLPIPDHL DCTEQLP
Length:667
Mass (Da):75,251
Last modified:January 1, 1998 - v1
Checksum:i673C5120018BA619
GO
Isoform 2 (identifier: O15344-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     553-667: Missing.

Show »
Length:552
Mass (Da):62,288
Checksum:iFD4D4C0EA5915DB2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228T → P in AAC32999 (PubMed:9722948).Curated1
Sequence conflicti484Q → P in AAC32998 (PubMed:9722948).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013758266C → R in GBBB1. 1 Publication1
Natural variantiVAR_025495295L → P in GBBB1. 1 PublicationCorresponds to variant rs104894866dbSNPEnsembl.1
Natural variantiVAR_025496391 – 392LC → R in GBBB1. 1 Publication2
Natural variantiVAR_013759438Missing in GBBB1. 1 Publication1
Natural variantiVAR_013760534V → VFIDSGRHL in GBBB1. 1
Natural variantiVAR_013761536I → T in GBBB1. 1 Publication1
Natural variantiVAR_013762626L → P in GBBB1. 1 PublicationCorresponds to variant rs28934611dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005735553 – 667Missing in isoform 2. 2 PublicationsAdd BLAST115

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13667 mRNA. Translation: CAA74018.1.
AF035360 mRNA. Translation: AAB99951.1.
AF041206 mRNA. Translation: AAC32998.1.
AF041207 mRNA. Translation: AAC32999.1.
AF041208 mRNA. Translation: AAC33000.1.
AF041209 mRNA. Translation: AAC33001.1.
AF041210 mRNA. Translation: AAC33002.1.
AF230976 mRNA. Translation: AAG50191.1.
AF230977 mRNA. Translation: AAG50192.1.
AF269101 mRNA. Translation: AAG33130.1.
AK315095 mRNA. Translation: BAG37559.1.
CH471074 Genomic DNA. Translation: EAW98780.1.
BC053626 mRNA. Translation: AAH53626.1.
CCDSiCCDS14138.1. [O15344-1]
PIRiT09482.
RefSeqiNP_000372.1. NM_000381.3. [O15344-1]
NP_001092094.1. NM_001098624.2. [O15344-1]
NP_001180206.1. NM_001193277.1. [O15344-1]
NP_001180207.1. NM_001193278.1.
NP_001180208.1. NM_001193279.1.
NP_001180209.1. NM_001193280.1.
NP_001180210.1. NM_001193281.1.
NP_150632.1. NM_033290.3. [O15344-1]
XP_016885025.1. XM_017029536.1. [O15344-1]
XP_016885029.1. XM_017029540.1. [O15344-2]
UniGeneiHs.27695.
Hs.460482.
Hs.689953.
Hs.738954.

Genome annotation databases

EnsembliENST00000317552; ENSP00000312678; ENSG00000101871. [O15344-1]
ENST00000380779; ENSP00000370156; ENSG00000101871. [O15344-1]
ENST00000380780; ENSP00000370157; ENSG00000101871. [O15344-1]
ENST00000380782; ENSP00000370159; ENSG00000101871. [O15344-2]
ENST00000380785; ENSP00000370162; ENSG00000101871. [O15344-1]
ENST00000380787; ENSP00000370164; ENSG00000101871. [O15344-1]
ENST00000453318; ENSP00000414521; ENSG00000101871. [O15344-1]
GeneIDi4281.
KEGGihsa:4281.
UCSCiuc004cte.5. human. [O15344-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13667 mRNA. Translation: CAA74018.1.
AF035360 mRNA. Translation: AAB99951.1.
AF041206 mRNA. Translation: AAC32998.1.
AF041207 mRNA. Translation: AAC32999.1.
AF041208 mRNA. Translation: AAC33000.1.
AF041209 mRNA. Translation: AAC33001.1.
AF041210 mRNA. Translation: AAC33002.1.
AF230976 mRNA. Translation: AAG50191.1.
AF230977 mRNA. Translation: AAG50192.1.
AF269101 mRNA. Translation: AAG33130.1.
AK315095 mRNA. Translation: BAG37559.1.
CH471074 Genomic DNA. Translation: EAW98780.1.
BC053626 mRNA. Translation: AAH53626.1.
CCDSiCCDS14138.1. [O15344-1]
PIRiT09482.
RefSeqiNP_000372.1. NM_000381.3. [O15344-1]
NP_001092094.1. NM_001098624.2. [O15344-1]
NP_001180206.1. NM_001193277.1. [O15344-1]
NP_001180207.1. NM_001193278.1.
NP_001180208.1. NM_001193279.1.
NP_001180209.1. NM_001193280.1.
NP_001180210.1. NM_001193281.1.
NP_150632.1. NM_033290.3. [O15344-1]
XP_016885025.1. XM_017029536.1. [O15344-1]
XP_016885029.1. XM_017029540.1. [O15344-2]
UniGeneiHs.27695.
Hs.460482.
Hs.689953.
Hs.738954.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DQ5NMR-A168-214[»]
2FFWNMR-A87-164[»]
2JUNNMR-A114-214[»]
5IM8NMR-A320-379[»]
ProteinModelPortaliO15344.
SMRiO15344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110427. 73 interactors.
IntActiO15344. 37 interactors.
STRINGi9606.ENSP00000312678.

PTM databases

iPTMnetiO15344.
PhosphoSitePlusiO15344.

Polymorphism and mutation databases

BioMutaiMID1.

Proteomic databases

MaxQBiO15344.
PaxDbiO15344.
PeptideAtlasiO15344.
PRIDEiO15344.

Protocols and materials databases

DNASUi4281.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317552; ENSP00000312678; ENSG00000101871. [O15344-1]
ENST00000380779; ENSP00000370156; ENSG00000101871. [O15344-1]
ENST00000380780; ENSP00000370157; ENSG00000101871. [O15344-1]
ENST00000380782; ENSP00000370159; ENSG00000101871. [O15344-2]
ENST00000380785; ENSP00000370162; ENSG00000101871. [O15344-1]
ENST00000380787; ENSP00000370164; ENSG00000101871. [O15344-1]
ENST00000453318; ENSP00000414521; ENSG00000101871. [O15344-1]
GeneIDi4281.
KEGGihsa:4281.
UCSCiuc004cte.5. human. [O15344-1]

Organism-specific databases

CTDi4281.
DisGeNETi4281.
GeneCardsiMID1.
GeneReviewsiMID1.
HGNCiHGNC:7095. MID1.
HPAiHPA003715.
MalaCardsiMID1.
MIMi300000. phenotype.
300552. gene.
neXtProtiNX_O15344.
OpenTargetsiENSG00000101871.
Orphaneti306597. X-linked Opitz G/BBB syndrome.
PharmGKBiPA30816.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITFU. Eukaryota.
ENOG410Z43Q. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000049193.
HOVERGENiHBG056432.
InParanoidiO15344.
KOiK08285.
OMAiRERAFDS.
OrthoDBiEOG091G02K9.
PhylomeDBiO15344.
TreeFamiTF333654.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101871-MONOMER.
ReactomeiR-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSiMID1. human.
EvolutionaryTraceiO15344.
GeneWikiiMID1.
GenomeRNAii4281.
PROiO15344.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101871.
CleanExiHS_MID1.
ExpressionAtlasiO15344. baseline and differential.
GenevisibleiO15344. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR027727. MID1.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR24103:SF26. PTHR24103:SF26. 3 hits.
PfamiPF00041. fn3. 1 hit.
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI18_HUMAN
AccessioniPrimary (citable) accession number: O15344
Secondary accession number(s): B2RCG2, O75361, Q9BZX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 182 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.