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O15342 (VA0E1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
V-type proton ATPase subunit e 1

Short name=V-ATPase subunit e 1
Alternative name(s):
V-ATPase 9.2 kDa membrane accessory protein
V-ATPase M9.2 subunit
Vacuolar proton pump subunit e 1
Gene names
Name:ATP6V0E1
Synonyms:ATP6H, ATP6V0E
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length81 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subunit structure

Composed of at least 10 subunits.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Ubiquitous. Ref.7

Sequence similarities

Belongs to the V-ATPase e1/e2 subunit family.

Sequence caution

The sequence CAA75571.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processHydrogen ion transport
Ion transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processATP hydrolysis coupled proton transport

Inferred from electronic annotation. Source: InterPro

cell growth

Inferred from genetic interaction Ref.7. Source: UniProtKB

cellular iron ion homeostasis

Traceable author statement. Source: Reactome

insulin receptor signaling pathway

Traceable author statement. Source: Reactome

interaction with host

Traceable author statement. Source: Reactome

phagosome maturation

Traceable author statement. Source: Reactome

proton transport

Traceable author statement Ref.1. Source: ProtInc

response to amino acid

Inferred from electronic annotation. Source: Ensembl

transferrin transport

Traceable author statement. Source: Reactome

transmembrane transport

Traceable author statement. Source: Reactome

vacuolar acidification

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentendosome membrane

Traceable author statement. Source: Reactome

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Traceable author statement Ref.1. Source: ProtInc

phagocytic vesicle membrane

Traceable author statement. Source: Reactome

proton-transporting V-type ATPase, V0 domain

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATPase activity, coupled to transmembrane movement of ions

Inferred from sequence or structural similarity. Source: UniProtKB

proton-transporting ATPase activity, rotational mechanism

Traceable author statement Ref.1. Source: ProtInc

transporter activity

Non-traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 8180V-type proton ATPase subunit e 1
PRO_0000071740

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane36 – 5621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O15342 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 9A47F16FDD2B2027

FASTA819,374
        10         20         30         40         50         60 
MAYHGLTVPL IVMSVFWGFV GFLVPWFIPK GPNRGVIITM LVTCSVCCYL FWLIAILAQL 

        70         80 
NPLFGPQLKN ETIWYLKYHW P 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules."
Ludwig J., Kerscher S., Brandt U., Pfeiffer K., Getlawi F., Apps D.K., Schaegger H.
J. Biol. Chem. 273:10939-10947(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]"Molecular cloning and characterization of a novel form of the human vacuolar H+-ATPase e-subunit: an essential proton pump component."
Blake-Palmer K.G., Su Y., Smith A.N., Karet F.E.
Gene 393:94-100(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y15286 mRNA. Translation: CAA75571.1. Different initiation.
CR456856 mRNA. Translation: CAG33137.1.
CR542131 mRNA. Translation: CAG46928.1.
AK312068 mRNA. Translation: BAG35004.1.
CH471062 Genomic DNA. Translation: EAW61417.1.
CH471062 Genomic DNA. Translation: EAW61418.1.
BC119714 mRNA. Translation: AAI19715.1.
BC119715 mRNA. Translation: AAI19716.1.
RefSeqNP_003936.1. NM_003945.3.
UniGeneHs.484188.

3D structure databases

ProteinModelPortalO15342.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000265093.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000517669; ENSP00000427941; ENSG00000113732.
ENST00000519374; ENSP00000429690; ENSG00000113732.
GeneID8992.
KEGGhsa:8992.
UCSCuc003mcd.1. human.

Organism-specific databases

CTD8992.
GeneCardsGC05P172410.
HGNCHGNC:863. ATP6V0E1.
MIM603931. gene.
neXtProtNX_O15342.
PharmGKBPA25151.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG293344.
HOGENOMHOG000265078.
HOVERGENHBG003974.
InParanoidO15342.
KOK02153.
OMAKTIRWIS.
OrthoDBEOG7B31QD.
PhylomeDBO15342.
TreeFamTF300290.

Enzyme and pathway databases

BioCycMetaCyc:HS03712-MONOMER.
ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressO15342.
BgeeO15342.
CleanExHS_ATP6V0E1.
GenevestigatorO15342.

Family and domain databases

InterProIPR008389. ATPase_V0-cplx_e1/e2_su.
IPR017385. ATPase_V0-cplx_e1/e2_su_met.
[Graphical view]
PANTHERPTHR12263. PTHR12263. 1 hit.
PfamPF05493. ATP_synt_H. 1 hit.
[Graphical view]
PIRSFPIRSF038097. V-ATP_synth_e1/e2. 1 hit.
ProtoNetSearch...

Other

ChiTaRSATP6V0E1. human.
GeneWikiATP6V0E1.
GenomeRNAi8992.
NextBio33719.
PROO15342.
SOURCESearch...

Entry information

Entry nameVA0E1_HUMAN
AccessionPrimary (citable) accession number: O15342
Secondary accession number(s): B2R557, D3DQM1, Q6IBE8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM