Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

V-type proton ATPase subunit e 1

Gene

ATP6V0E1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  • ATPase coupled ion transmembrane transporter activity Source: UniProtKB
  • proton-transporting ATPase activity, rotational mechanism Source: ProtInc
  • transporter activity Source: ProtInc

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • cell growth Source: UniProtKB
  • insulin receptor signaling pathway Source: Reactome
  • ion transmembrane transport Source: Reactome
  • phagosome acidification Source: Reactome
  • proton transport Source: ProtInc
  • regulation of macroautophagy Source: ParkinsonsUK-UCL
  • transferrin transport Source: Reactome
  • vacuolar acidification Source: UniProtKB

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS03712-MONOMER.
ReactomeiR-HSA-1222556. ROS, RNS production in phagocytes.
R-HSA-77387. Insulin receptor recycling.
R-HSA-917977. Transferrin endocytosis and recycling.
R-HSA-983712. Ion channel transport.
SIGNORiO15342.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit e 1
Short name:
V-ATPase subunit e 1
Alternative name(s):
V-ATPase 9.2 kDa membrane accessory protein
V-ATPase M9.2 subunit
Vacuolar proton pump subunit e 1
Gene namesi
Name:ATP6V0E1
Synonyms:ATP6H, ATP6V0E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113732.8.
HGNCiHGNC:863. ATP6V0E1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113732.
PharmGKBiPA25151.

Polymorphism and mutation databases

BioMutaiATP6V0E1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717401 – 81V-type proton ATPase subunit e 1Add BLAST81

Proteomic databases

PaxDbiO15342.
PRIDEiO15342.
TopDownProteomicsiO15342.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000113732.
CleanExiHS_ATP6V0E1.
ExpressionAtlasiO15342. baseline and differential.
GenevisibleiO15342. HS.

Interactioni

Subunit structurei

Composed of at least 10 subunits.

Protein-protein interaction databases

BioGridi114473. 11 interactors.
IntActiO15342. 1 interactor.
STRINGi9606.ENSP00000427941.

Structurei

3D structure databases

ProteinModelPortaliO15342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase e1/e2 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3500. Eukaryota.
ENOG41121M0. LUCA.
GeneTreeiENSGT00390000000728.
HOGENOMiHOG000265078.
HOVERGENiHBG003974.
InParanoidiO15342.
KOiK02153.
OMAiGVVPWFI.
OrthoDBiEOG091G113P.
PhylomeDBiO15342.
TreeFamiTF300290.

Family and domain databases

InterProiView protein in InterPro
IPR008389. ATPase_V0-cplx_e1/e2_su.
IPR017385. ATPase_V0-cplx_e1/e2_su_met.
PANTHERiPTHR12263. PTHR12263. 1 hit.
PfamiView protein in Pfam
PF05493. ATP_synt_H. 1 hit.
PIRSFiPIRSF038097. V-ATP_synth_e1/e2. 1 hit.

Sequencei

Sequence statusi: Complete.

O15342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYHGLTVPL IVMSVFWGFV GFLVPWFIPK GPNRGVIITM LVTCSVCCYL
60 70 80
FWLIAILAQL NPLFGPQLKN ETIWYLKYHW P
Length:81
Mass (Da):9,374
Last modified:January 23, 2007 - v2
Checksum:i9A47F16FDD2B2027
GO

Sequence cautioni

The sequence CAA75571 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15286 mRNA. Translation: CAA75571.1. Different initiation.
CR456856 mRNA. Translation: CAG33137.1.
CR542131 mRNA. Translation: CAG46928.1.
AK312068 mRNA. Translation: BAG35004.1.
CH471062 Genomic DNA. Translation: EAW61417.1.
CH471062 Genomic DNA. Translation: EAW61418.1.
BC119714 mRNA. Translation: AAI19715.1.
BC119715 mRNA. Translation: AAI19716.1.
CCDSiCCDS4383.1.
RefSeqiNP_003936.1. NM_003945.3.
UniGeneiHs.484188.

Genome annotation databases

EnsembliENST00000517669; ENSP00000427941; ENSG00000113732.
ENST00000519374; ENSP00000429690; ENSG00000113732.
GeneIDi8992.
KEGGihsa:8992.
UCSCiuc003mcd.2. human.

Similar proteinsi

Entry informationi

Entry nameiVA0E1_HUMAN
AccessioniPrimary (citable) accession number: O15342
Secondary accession number(s): B2R557, D3DQM1, Q6IBE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families