O15342 (VA0E1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-type proton ATPase subunit e 1
Short name=V-ATPase subunit e 1

Alternative name(s):
V-ATPase 9.2 kDa membrane accessory protein
V-ATPase M9.2 subunit
Vacuolar proton pump subunit e 1

Gene names

Name:	ATP6V0E1
Synonyms:	ATP6H, ATP6V0E

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	81 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subunit structure	Composed of at least 10 subunits.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Ubiquitous. Ref.7
Sequence similarities	Belongs to the V-ATPase e1/e2 subunit family.
Sequence caution	The sequence CAA75571.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro cell growth Inferred from genetic interaction Ref.7. Source: UniProtKB cellular iron ion homeostasis Traceable author statement. Source: Reactome insulin receptor signaling pathway Traceable author statement. Source: Reactome interaction with host Traceable author statement. Source: Reactome phagosome maturation Traceable author statement. Source: Reactome response to amino acid stimulus Inferred from electronic annotation. Source: Compara transferrin transport Traceable author statement. Source: Reactome vacuolar acidification Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	endosome membrane Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW phagocytic vesicle membrane Traceable author statement. Source: Reactome proton-transporting V-type ATPase, V0 domain Inferred from electronic annotation. Source: InterPro
Molecular_function	proton-transporting ATPase activity, rotational mechanism Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 81	80	V-type proton ATPase subunit e 1		PRO_0000071740
Regions
	Transmembrane	8 – 28	21	Helical; Potential
	Transmembrane	36 – 56	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O15342 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 9A47F16FDD2B2027	FASTA	81	9,374
	10 20 30 40 50 60 MAYHGLTVPL IVMSVFWGFV GFLVPWFIPK GPNRGVIITM LVTCSVCCYL FWLIAILAQL 70 80 NPLFGPQLKN ETIWYLKYHW P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules." Ludwig J., Kerscher S., Brandt U., Pfeiffer K., Getlawi F., Apps D.K., Schaegger H. J. Biol. Chem. 273:10939-10947(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Molecular cloning and characterization of a novel form of the human vacuolar H+-ATPase e-subunit: an essential proton pump component." Blake-Palmer K.G., Su Y., Smith A.N., Karet F.E. Gene 393:94-100(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y15286 mRNA. Translation: CAA75571.1. Different initiation. CR456856 mRNA. Translation: CAG33137.1. CR542131 mRNA. Translation: CAG46928.1. AK312068 mRNA. Translation: BAG35004.1. CH471062 Genomic DNA. Translation: EAW61417.1. CH471062 Genomic DNA. Translation: EAW61418.1. BC119714 mRNA. Translation: AAI19715.1. BC119715 mRNA. Translation: AAI19716.1.
IPI	IPI00217058.
RefSeq	NP_003936.1. NM_003945.3.
UniGene	Hs.484188.
3D structure databases
ProteinModelPortal	O15342.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000265093.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000517669; ENSP00000427941; ENSG00000113732. ENST00000519374; ENSP00000429690; ENSG00000113732.
GeneID	8992.
KEGG	hsa:8992.
UCSC	uc003mcd.1. human.
Organism-specific databases
CTD	8992.
GeneCards	GC05P172410.
HGNC	HGNC:863. ATP6V0E1.
MIM	603931. gene.
neXtProt	NX_O15342.
PharmGKB	PA25151.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG293344.
HOGENOM	HOG000265078.
HOVERGEN	HBG003974.
InParanoid	O15342.
KO	K02153.
OMA	KTIRWIS.
OrthoDB	EOG428236.
PhylomeDB	O15342.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_116125. Disease. REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	O15342.
Bgee	O15342.
CleanEx	HS_ATP6V0E1.
Genevestigator	O15342.
GermOnline	ENSG00000113732. Homo sapiens.
Family and domain databases
InterPro	IPR008389. ATPase_V0-cplx_e1/e2_su. IPR017385. ATPase_V0-cplx_e1/e2_su_met. [Graphical view]
PANTHER	PTHR12263. PTHR12263. 1 hit.
Pfam	PF05493. ATP_synt_H. 1 hit. [Graphical view]
PIRSF	PIRSF038097. V-ATP_synth_e1/e2. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	ATP6V0E1. human.
GenomeRNAi	8992.
NextBio	33719.
SOURCE	Search...

Entry information

Entry name

VA0E1_HUMAN

Accession

Primary (citable) accession number: O15342
Secondary accession number(s): B2R557, D3DQM1, Q6IBE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.