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O15342

- VA0E1_HUMAN

UniProt

O15342 - VA0E1_HUMAN

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Protein

V-type proton ATPase subunit e 1

Gene

ATP6V0E1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of ions Source: UniProtKB
  2. proton-transporting ATPase activity, rotational mechanism Source: ProtInc
  3. transporter activity Source: ProtInc

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. cell growth Source: UniProtKB
  3. cellular iron ion homeostasis Source: Reactome
  4. insulin receptor signaling pathway Source: Reactome
  5. interaction with host Source: Reactome
  6. phagosome maturation Source: Reactome
  7. proton transport Source: ProtInc
  8. response to amino acid Source: Ensembl
  9. transferrin transport Source: Reactome
  10. transmembrane transport Source: Reactome
  11. vacuolar acidification Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS03712-MONOMER.
ReactomeiREACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit e 1
Short name:
V-ATPase subunit e 1
Alternative name(s):
V-ATPase 9.2 kDa membrane accessory protein
V-ATPase M9.2 subunit
Vacuolar proton pump subunit e 1
Gene namesi
Name:ATP6V0E1
Synonyms:ATP6H, ATP6V0E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:863. ATP6V0E1.

Subcellular locationi

GO - Cellular componenti

  1. endosome membrane Source: Reactome
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: ProtInc
  4. phagocytic vesicle membrane Source: Reactome
  5. proton-transporting V-type ATPase, V0 domain Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25151.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 8180V-type proton ATPase subunit e 1PRO_0000071740Add
BLAST

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiO15342.
CleanExiHS_ATP6V0E1.
ExpressionAtlasiO15342. baseline and differential.
GenevestigatoriO15342.

Interactioni

Subunit structurei

Composed of at least 10 subunits.

Protein-protein interaction databases

STRINGi9606.ENSP00000265093.

Structurei

3D structure databases

ProteinModelPortaliO15342.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence AnalysisAdd
BLAST
Transmembranei36 – 5621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase e1/e2 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293344.
GeneTreeiENSGT00390000000728.
HOGENOMiHOG000265078.
HOVERGENiHBG003974.
InParanoidiO15342.
KOiK02153.
OMAiKTIRWIS.
OrthoDBiEOG7B31QD.
PhylomeDBiO15342.
TreeFamiTF300290.

Family and domain databases

InterProiIPR008389. ATPase_V0-cplx_e1/e2_su.
IPR017385. ATPase_V0-cplx_e1/e2_su_met.
[Graphical view]
PANTHERiPTHR12263. PTHR12263. 1 hit.
PfamiPF05493. ATP_synt_H. 1 hit.
[Graphical view]
PIRSFiPIRSF038097. V-ATP_synth_e1/e2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15342-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYHGLTVPL IVMSVFWGFV GFLVPWFIPK GPNRGVIITM LVTCSVCCYL
60 70 80
FWLIAILAQL NPLFGPQLKN ETIWYLKYHW P
Length:81
Mass (Da):9,374
Last modified:January 23, 2007 - v2
Checksum:i9A47F16FDD2B2027
GO

Sequence cautioni

The sequence CAA75571.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15286 mRNA. Translation: CAA75571.1. Different initiation.
CR456856 mRNA. Translation: CAG33137.1.
CR542131 mRNA. Translation: CAG46928.1.
AK312068 mRNA. Translation: BAG35004.1.
CH471062 Genomic DNA. Translation: EAW61417.1.
CH471062 Genomic DNA. Translation: EAW61418.1.
BC119714 mRNA. Translation: AAI19715.1.
BC119715 mRNA. Translation: AAI19716.1.
CCDSiCCDS4383.1.
RefSeqiNP_003936.1. NM_003945.3.
UniGeneiHs.484188.

Genome annotation databases

EnsembliENST00000517669; ENSP00000427941; ENSG00000113732.
ENST00000519374; ENSP00000429690; ENSG00000113732.
GeneIDi8992.
KEGGihsa:8992.
UCSCiuc003mcd.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15286 mRNA. Translation: CAA75571.1 . Different initiation.
CR456856 mRNA. Translation: CAG33137.1 .
CR542131 mRNA. Translation: CAG46928.1 .
AK312068 mRNA. Translation: BAG35004.1 .
CH471062 Genomic DNA. Translation: EAW61417.1 .
CH471062 Genomic DNA. Translation: EAW61418.1 .
BC119714 mRNA. Translation: AAI19715.1 .
BC119715 mRNA. Translation: AAI19716.1 .
CCDSi CCDS4383.1.
RefSeqi NP_003936.1. NM_003945.3.
UniGenei Hs.484188.

3D structure databases

ProteinModelPortali O15342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000265093.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000517669 ; ENSP00000427941 ; ENSG00000113732 .
ENST00000519374 ; ENSP00000429690 ; ENSG00000113732 .
GeneIDi 8992.
KEGGi hsa:8992.
UCSCi uc003mcd.1. human.

Organism-specific databases

CTDi 8992.
GeneCardsi GC05P172410.
HGNCi HGNC:863. ATP6V0E1.
MIMi 603931. gene.
neXtProti NX_O15342.
PharmGKBi PA25151.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293344.
GeneTreei ENSGT00390000000728.
HOGENOMi HOG000265078.
HOVERGENi HBG003974.
InParanoidi O15342.
KOi K02153.
OMAi KTIRWIS.
OrthoDBi EOG7B31QD.
PhylomeDBi O15342.
TreeFami TF300290.

Enzyme and pathway databases

BioCyci MetaCyc:HS03712-MONOMER.
Reactomei REACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Miscellaneous databases

ChiTaRSi ATP6V0E1. human.
GeneWikii ATP6V0E1.
GenomeRNAii 8992.
NextBioi 33719.
PROi O15342.
SOURCEi Search...

Gene expression databases

Bgeei O15342.
CleanExi HS_ATP6V0E1.
ExpressionAtlasi O15342. baseline and differential.
Genevestigatori O15342.

Family and domain databases

InterProi IPR008389. ATPase_V0-cplx_e1/e2_su.
IPR017385. ATPase_V0-cplx_e1/e2_su_met.
[Graphical view ]
PANTHERi PTHR12263. PTHR12263. 1 hit.
Pfami PF05493. ATP_synt_H. 1 hit.
[Graphical view ]
PIRSFi PIRSF038097. V-ATP_synth_e1/e2. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules."
    Ludwig J., Kerscher S., Brandt U., Pfeiffer K., Getlawi F., Apps D.K., Schaegger H.
    J. Biol. Chem. 273:10939-10947(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Molecular cloning and characterization of a novel form of the human vacuolar H+-ATPase e-subunit: an essential proton pump component."
    Blake-Palmer K.G., Su Y., Smith A.N., Karet F.E.
    Gene 393:94-100(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiVA0E1_HUMAN
AccessioniPrimary (citable) accession number: O15342
Secondary accession number(s): B2R557, D3DQM1, Q6IBE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3