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O15335

- CHAD_HUMAN

UniProt

O15335 - CHAD_HUMAN

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Protein
Chondroadherin
Gene
CHAD, SLRR4A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha2beta1. May play an important role in the regulation of chondrocyte growth and proliferation By similarity.

GO - Biological processi

  1. cartilage condensation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroadherin
Alternative name(s):
Cartilage leucine-rich protein
Gene namesi
Name:CHAD
Synonyms:SLRR4A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:1909. CHAD.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26445.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 359337Chondroadherin
PRO_0000032773Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 38 By similarity
Glycosylationi144 – 1441O-linked (GalNAc...) Reviewed prediction
Disulfide bondi304 ↔ 346 By similarity
Disulfide bondi306 ↔ 326 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO15335.
PRIDEiO15335.

Expressioni

Tissue specificityi

Present in chondrocytes at all ages.

Gene expression databases

BgeeiO15335.
CleanExiHS_CHAD.
GenevestigatoriO15335.

Organism-specific databases

HPAiHPA018241.

Interactioni

Subunit structurei

Mostly monomeric By similarity. Interacts with collagen type II.

Protein-protein interaction databases

STRINGi9606.ENSP00000258969.

Structurei

3D structure databases

ProteinModelPortaliO15335.
SMRiO15335. Positions 23-337.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 5230LRRNT
Add
BLAST
Repeati76 – 9722LRR 1
Add
BLAST
Repeati100 – 12122LRR 2
Add
BLAST
Repeati124 – 14522LRR 3
Add
BLAST
Repeati148 – 16922LRR 4
Add
BLAST
Repeati172 – 19322LRR 5
Add
BLAST
Repeati196 – 21722LRR 6
Add
BLAST
Repeati220 – 24122LRR 7
Add
BLAST
Repeati245 – 26622LRR 8
Add
BLAST
Repeati269 – 29022LRR 9
Add
BLAST
Domaini300 – 34849LRRCT
Add
BLAST

Sequence similaritiesi

Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000013150.
HOVERGENiHBG005324.
InParanoidiO15335.
KOiK06248.
OMAiCHCHGGD.
PhylomeDBiO15335.
TreeFamiTF332659.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15335-1 [UniParc]FASTAAdd to Basket

« Hide

MVRPMLLLSL GLLAGLLPAL AACPQNCHCH SDLQHVICDK VGLQKIPKVS    50
EKTKLLNLQR NNFPVLAANS FRAMPNLVSL HLQHCQIREV AAGAFRGLKQ 100
LIYLYLSHND IRVLRAGAFD DLTELTYLYL DHNKVTELPR GLLSPLVNLF 150
ILQLNNNKIR ELRAGAFQGA KDLRWLYLSE NALSSLQPGA LDDVENLAKF 200
HVDRNQLSSY PSAALSKLRV VEELKLSHNP LKSIPDNAFQ SFGRYLETLW 250
LDNTNLEKFS DGAFLGVTTL KHVHLENNRL NQLPSNFPFD SLETLALTNN 300
PWKCTCQLRG LRRWLEAKAS RPDATCASPA KFKGQHIRDT DAFRSCKFPT 350
KRSKKAGRH 359
Length:359
Mass (Da):40,476
Last modified:February 20, 2007 - v2
Checksum:iCF24D2B5A5DFCF0C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti312 – 3121R → Q.
Corresponds to variant rs35218093 [ dbSNP | Ensembl ].
VAR_052019
Natural varianti350 – 3501T → I.
Corresponds to variant rs2231510 [ dbSNP | Ensembl ].
VAR_030631

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141L → V in AAC13410. 1 Publication
Sequence conflicti166 – 1661A → P in AAC13410. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U96769, U96767, U96768 Genomic DNA. Translation: AAC13410.1.
AF371328 mRNA. Translation: AAK51556.1.
AK292177 mRNA. Translation: BAF84866.1.
CH471109 Genomic DNA. Translation: EAW94613.1.
BC036360 mRNA. Translation: AAH36360.1.
BC073974 mRNA. Translation: AAH73974.1.
CCDSiCCDS11568.1.
RefSeqiNP_001258.2. NM_001267.2.
UniGeneiHs.97220.

Genome annotation databases

EnsembliENST00000258969; ENSP00000258969; ENSG00000136457.
ENST00000508540; ENSP00000423812; ENSG00000136457.
GeneIDi1101.
KEGGihsa:1101.
UCSCiuc010dbr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U96769 , U96767 , U96768 Genomic DNA. Translation: AAC13410.1 .
AF371328 mRNA. Translation: AAK51556.1 .
AK292177 mRNA. Translation: BAF84866.1 .
CH471109 Genomic DNA. Translation: EAW94613.1 .
BC036360 mRNA. Translation: AAH36360.1 .
BC073974 mRNA. Translation: AAH73974.1 .
CCDSi CCDS11568.1.
RefSeqi NP_001258.2. NM_001267.2.
UniGenei Hs.97220.

3D structure databases

ProteinModelPortali O15335.
SMRi O15335. Positions 23-337.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000258969.

Proteomic databases

PaxDbi O15335.
PRIDEi O15335.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258969 ; ENSP00000258969 ; ENSG00000136457 .
ENST00000508540 ; ENSP00000423812 ; ENSG00000136457 .
GeneIDi 1101.
KEGGi hsa:1101.
UCSCi uc010dbr.3. human.

Organism-specific databases

CTDi 1101.
GeneCardsi GC17M048541.
HGNCi HGNC:1909. CHAD.
HPAi HPA018241.
MIMi 602178. gene.
neXtProti NX_O15335.
PharmGKBi PA26445.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000013150.
HOVERGENi HBG005324.
InParanoidi O15335.
KOi K06248.
OMAi CHCHGGD.
PhylomeDBi O15335.
TreeFami TF332659.

Miscellaneous databases

GenomeRNAii 1101.
NextBioi 4554.
PROi O15335.
SOURCEi Search...

Gene expression databases

Bgeei O15335.
CleanExi HS_CHAD.
Genevestigatori O15335.

Family and domain databases

InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The structure and chromosome location of the human chondroadherin gene (CHAD)."
    Grover J., Chen X.-N., Korenberg J.R., Roughley P.J.
    Genomics 45:379-385(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCHAD_HUMAN
AccessioniPrimary (citable) accession number: O15335
Secondary accession number(s): A8K812, Q6GTU0, Q96RJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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