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Protein

Chondroadherin

Gene

CHAD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha2beta1. May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).By similarity

GO - Biological processi

  1. bone development Source: Ensembl
  2. cartilage condensation Source: Ensembl
  3. negative regulation of bone trabecula formation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroadherin
Alternative name(s):
Cartilage leucine-rich protein
Gene namesi
Name:CHAD
Synonyms:SLRR4A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:1909. CHAD.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26445.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 359337ChondroadherinPRO_0000032773Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 38By similarity
Glycosylationi144 – 1441O-linked (GalNAc...)Sequence Analysis
Disulfide bondi304 ↔ 346By similarity
Disulfide bondi306 ↔ 326By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO15335.
PRIDEiO15335.

Expressioni

Tissue specificityi

Present in chondrocytes at all ages.

Gene expression databases

BgeeiO15335.
CleanExiHS_CHAD.
GenevestigatoriO15335.

Organism-specific databases

HPAiHPA018241.

Interactioni

Subunit structurei

Mostly monomeric (By similarity). Interacts with collagen type II.By similarity

Protein-protein interaction databases

BioGridi107526. 2 interactions.
STRINGi9606.ENSP00000258969.

Structurei

3D structure databases

ProteinModelPortaliO15335.
SMRiO15335. Positions 21-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 5230LRRNTAdd
BLAST
Repeati76 – 9722LRR 1Add
BLAST
Repeati100 – 12122LRR 2Add
BLAST
Repeati124 – 14522LRR 3Add
BLAST
Repeati148 – 16922LRR 4Add
BLAST
Repeati172 – 19322LRR 5Add
BLAST
Repeati196 – 21722LRR 6Add
BLAST
Repeati220 – 24122LRR 7Add
BLAST
Repeati245 – 26622LRR 8Add
BLAST
Repeati269 – 29022LRR 9Add
BLAST
Domaini300 – 34849LRRCTAdd
BLAST

Sequence similaritiesi

Contains 9 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000013150.
HOVERGENiHBG005324.
InParanoidiO15335.
KOiK06248.
OMAiQHCQVRE.
PhylomeDBiO15335.
TreeFamiTF332659.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15335-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRPMLLLSL GLLAGLLPAL AACPQNCHCH SDLQHVICDK VGLQKIPKVS
60 70 80 90 100
EKTKLLNLQR NNFPVLAANS FRAMPNLVSL HLQHCQIREV AAGAFRGLKQ
110 120 130 140 150
LIYLYLSHND IRVLRAGAFD DLTELTYLYL DHNKVTELPR GLLSPLVNLF
160 170 180 190 200
ILQLNNNKIR ELRAGAFQGA KDLRWLYLSE NALSSLQPGA LDDVENLAKF
210 220 230 240 250
HVDRNQLSSY PSAALSKLRV VEELKLSHNP LKSIPDNAFQ SFGRYLETLW
260 270 280 290 300
LDNTNLEKFS DGAFLGVTTL KHVHLENNRL NQLPSNFPFD SLETLALTNN
310 320 330 340 350
PWKCTCQLRG LRRWLEAKAS RPDATCASPA KFKGQHIRDT DAFRSCKFPT

KRSKKAGRH
Length:359
Mass (Da):40,476
Last modified:February 20, 2007 - v2
Checksum:iCF24D2B5A5DFCF0C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141L → V in AAC13410. (PubMed:9344663)Curated
Sequence conflicti166 – 1661A → P in AAC13410. (PubMed:9344663)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti312 – 3121R → Q.
Corresponds to variant rs35218093 [ dbSNP | Ensembl ].
VAR_052019
Natural varianti350 – 3501T → I.
Corresponds to variant rs2231510 [ dbSNP | Ensembl ].
VAR_030631

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96769, U96767, U96768 Genomic DNA. Translation: AAC13410.1.
AF371328 mRNA. Translation: AAK51556.1.
AK292177 mRNA. Translation: BAF84866.1.
CH471109 Genomic DNA. Translation: EAW94613.1.
BC036360 mRNA. Translation: AAH36360.1.
BC073974 mRNA. Translation: AAH73974.1.
CCDSiCCDS11568.1.
RefSeqiNP_001258.2. NM_001267.2.
UniGeneiHs.97220.

Genome annotation databases

EnsembliENST00000258969; ENSP00000258969; ENSG00000136457.
ENST00000508540; ENSP00000423812; ENSG00000136457.
GeneIDi1101.
KEGGihsa:1101.
UCSCiuc010dbr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96769, U96767, U96768 Genomic DNA. Translation: AAC13410.1.
AF371328 mRNA. Translation: AAK51556.1.
AK292177 mRNA. Translation: BAF84866.1.
CH471109 Genomic DNA. Translation: EAW94613.1.
BC036360 mRNA. Translation: AAH36360.1.
BC073974 mRNA. Translation: AAH73974.1.
CCDSiCCDS11568.1.
RefSeqiNP_001258.2. NM_001267.2.
UniGeneiHs.97220.

3D structure databases

ProteinModelPortaliO15335.
SMRiO15335. Positions 21-337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107526. 2 interactions.
STRINGi9606.ENSP00000258969.

Proteomic databases

PaxDbiO15335.
PRIDEiO15335.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258969; ENSP00000258969; ENSG00000136457.
ENST00000508540; ENSP00000423812; ENSG00000136457.
GeneIDi1101.
KEGGihsa:1101.
UCSCiuc010dbr.3. human.

Organism-specific databases

CTDi1101.
GeneCardsiGC17M048541.
HGNCiHGNC:1909. CHAD.
HPAiHPA018241.
MIMi602178. gene.
neXtProtiNX_O15335.
PharmGKBiPA26445.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000013150.
HOVERGENiHBG005324.
InParanoidiO15335.
KOiK06248.
OMAiQHCQVRE.
PhylomeDBiO15335.
TreeFamiTF332659.

Miscellaneous databases

GenomeRNAii1101.
NextBioi4554.
PROiO15335.
SOURCEiSearch...

Gene expression databases

BgeeiO15335.
CleanExiHS_CHAD.
GenevestigatoriO15335.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The structure and chromosome location of the human chondroadherin gene (CHAD)."
    Grover J., Chen X.-N., Korenberg J.R., Roughley P.J.
    Genomics 45:379-385(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCHAD_HUMAN
AccessioniPrimary (citable) accession number: O15335
Secondary accession number(s): A8K812, Q6GTU0, Q96RJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: February 20, 2007
Last modified: January 7, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.