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O15335

- CHAD_HUMAN

UniProt

O15335 - CHAD_HUMAN

Protein

Chondroadherin

Gene

CHAD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha2beta1. May play an important role in the regulation of chondrocyte growth and proliferation By similarity.By similarity

    GO - Biological processi

    1. cartilage condensation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chondroadherin
    Alternative name(s):
    Cartilage leucine-rich protein
    Gene namesi
    Name:CHAD
    Synonyms:SLRR4A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:1909. CHAD.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26445.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 359337ChondroadherinPRO_0000032773Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi23 ↔ 38By similarity
    Glycosylationi144 – 1441O-linked (GalNAc...)Sequence Analysis
    Disulfide bondi304 ↔ 346By similarity
    Disulfide bondi306 ↔ 326By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO15335.
    PRIDEiO15335.

    Expressioni

    Tissue specificityi

    Present in chondrocytes at all ages.

    Gene expression databases

    BgeeiO15335.
    CleanExiHS_CHAD.
    GenevestigatoriO15335.

    Organism-specific databases

    HPAiHPA018241.

    Interactioni

    Subunit structurei

    Mostly monomeric By similarity. Interacts with collagen type II.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000258969.

    Structurei

    3D structure databases

    ProteinModelPortaliO15335.
    SMRiO15335. Positions 23-337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 5230LRRNTAdd
    BLAST
    Repeati76 – 9722LRR 1Add
    BLAST
    Repeati100 – 12122LRR 2Add
    BLAST
    Repeati124 – 14522LRR 3Add
    BLAST
    Repeati148 – 16922LRR 4Add
    BLAST
    Repeati172 – 19322LRR 5Add
    BLAST
    Repeati196 – 21722LRR 6Add
    BLAST
    Repeati220 – 24122LRR 7Add
    BLAST
    Repeati245 – 26622LRR 8Add
    BLAST
    Repeati269 – 29022LRR 9Add
    BLAST
    Domaini300 – 34849LRRCTAdd
    BLAST

    Sequence similaritiesi

    Contains 9 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000013150.
    HOVERGENiHBG005324.
    InParanoidiO15335.
    KOiK06248.
    OMAiCHCHGGD.
    PhylomeDBiO15335.
    TreeFamiTF332659.

    Family and domain databases

    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 2 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 5 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 10 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O15335-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRPMLLLSL GLLAGLLPAL AACPQNCHCH SDLQHVICDK VGLQKIPKVS    50
    EKTKLLNLQR NNFPVLAANS FRAMPNLVSL HLQHCQIREV AAGAFRGLKQ 100
    LIYLYLSHND IRVLRAGAFD DLTELTYLYL DHNKVTELPR GLLSPLVNLF 150
    ILQLNNNKIR ELRAGAFQGA KDLRWLYLSE NALSSLQPGA LDDVENLAKF 200
    HVDRNQLSSY PSAALSKLRV VEELKLSHNP LKSIPDNAFQ SFGRYLETLW 250
    LDNTNLEKFS DGAFLGVTTL KHVHLENNRL NQLPSNFPFD SLETLALTNN 300
    PWKCTCQLRG LRRWLEAKAS RPDATCASPA KFKGQHIRDT DAFRSCKFPT 350
    KRSKKAGRH 359
    Length:359
    Mass (Da):40,476
    Last modified:February 20, 2007 - v2
    Checksum:iCF24D2B5A5DFCF0C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1141L → V in AAC13410. (PubMed:9344663)Curated
    Sequence conflicti166 – 1661A → P in AAC13410. (PubMed:9344663)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti312 – 3121R → Q.
    Corresponds to variant rs35218093 [ dbSNP | Ensembl ].
    VAR_052019
    Natural varianti350 – 3501T → I.
    Corresponds to variant rs2231510 [ dbSNP | Ensembl ].
    VAR_030631

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U96769, U96767, U96768 Genomic DNA. Translation: AAC13410.1.
    AF371328 mRNA. Translation: AAK51556.1.
    AK292177 mRNA. Translation: BAF84866.1.
    CH471109 Genomic DNA. Translation: EAW94613.1.
    BC036360 mRNA. Translation: AAH36360.1.
    BC073974 mRNA. Translation: AAH73974.1.
    CCDSiCCDS11568.1.
    RefSeqiNP_001258.2. NM_001267.2.
    UniGeneiHs.97220.

    Genome annotation databases

    EnsembliENST00000258969; ENSP00000258969; ENSG00000136457.
    ENST00000508540; ENSP00000423812; ENSG00000136457.
    GeneIDi1101.
    KEGGihsa:1101.
    UCSCiuc010dbr.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U96769 , U96767 , U96768 Genomic DNA. Translation: AAC13410.1 .
    AF371328 mRNA. Translation: AAK51556.1 .
    AK292177 mRNA. Translation: BAF84866.1 .
    CH471109 Genomic DNA. Translation: EAW94613.1 .
    BC036360 mRNA. Translation: AAH36360.1 .
    BC073974 mRNA. Translation: AAH73974.1 .
    CCDSi CCDS11568.1.
    RefSeqi NP_001258.2. NM_001267.2.
    UniGenei Hs.97220.

    3D structure databases

    ProteinModelPortali O15335.
    SMRi O15335. Positions 23-337.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000258969.

    Proteomic databases

    PaxDbi O15335.
    PRIDEi O15335.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258969 ; ENSP00000258969 ; ENSG00000136457 .
    ENST00000508540 ; ENSP00000423812 ; ENSG00000136457 .
    GeneIDi 1101.
    KEGGi hsa:1101.
    UCSCi uc010dbr.3. human.

    Organism-specific databases

    CTDi 1101.
    GeneCardsi GC17M048541.
    HGNCi HGNC:1909. CHAD.
    HPAi HPA018241.
    MIMi 602178. gene.
    neXtProti NX_O15335.
    PharmGKBi PA26445.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000013150.
    HOVERGENi HBG005324.
    InParanoidi O15335.
    KOi K06248.
    OMAi CHCHGGD.
    PhylomeDBi O15335.
    TreeFami TF332659.

    Miscellaneous databases

    GenomeRNAii 1101.
    NextBioi 4554.
    PROi O15335.
    SOURCEi Search...

    Gene expression databases

    Bgeei O15335.
    CleanExi HS_CHAD.
    Genevestigatori O15335.

    Family and domain databases

    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 2 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 5 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The structure and chromosome location of the human chondroadherin gene (CHAD)."
      Grover J., Chen X.-N., Korenberg J.R., Roughley P.J.
      Genomics 45:379-385(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCHAD_HUMAN
    AccessioniPrimary (citable) accession number: O15335
    Secondary accession number(s): A8K812, Q6GTU0, Q96RJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3