Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chondroadherin

Gene

CHAD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha2beta1. May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroadherin
Alternative name(s):
Cartilage leucine-rich protein
Gene namesi
Name:CHAD
Synonyms:SLRR4A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:1909. CHAD.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1101.
OpenTargetsiENSG00000136457.
PharmGKBiPA26445.

Polymorphism and mutation databases

BioMutaiCHAD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003277323 – 359ChondroadherinAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 38By similarity
Glycosylationi144O-linked (GalNAc...)Sequence analysis1
Disulfide bondi304 ↔ 346By similarity
Disulfide bondi306 ↔ 326By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO15335.
PeptideAtlasiO15335.
PRIDEiO15335.

PTM databases

PhosphoSitePlusiO15335.

Expressioni

Tissue specificityi

Present in chondrocytes at all ages.

Gene expression databases

BgeeiENSG00000136457.
CleanExiHS_CHAD.
ExpressionAtlasiO15335. baseline and differential.
GenevisibleiO15335. HS.

Organism-specific databases

HPAiHPA018241.

Interactioni

Subunit structurei

Mostly monomeric (By similarity). Interacts with collagen type II.By similarity

Protein-protein interaction databases

BioGridi107526. 2 interactors.
STRINGi9606.ENSP00000258969.

Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 30Combined sources3
Turni31 – 34Combined sources4
Beta strandi35 – 37Combined sources3
Beta strandi55 – 57Combined sources3
Beta strandi64 – 66Combined sources3
Turni68 – 73Combined sources6
Beta strandi79 – 81Combined sources3
Turni92 – 97Combined sources6
Beta strandi103 – 105Combined sources3
Turni116 – 121Combined sources6
Beta strandi127 – 129Combined sources3
Turni140 – 145Combined sources6
Beta strandi151 – 153Combined sources3
Turni164 – 169Combined sources6
Beta strandi175 – 177Combined sources3
Turni188 – 191Combined sources4
Helixi192 – 194Combined sources3
Beta strandi198 – 201Combined sources4
Helixi212 – 215Combined sources4
Beta strandi222 – 225Combined sources4
Turni236 – 239Combined sources4
Helixi240 – 242Combined sources3
Turni243 – 245Combined sources3
Beta strandi248 – 250Combined sources3
Turni261 – 266Combined sources6
Beta strandi272 – 274Combined sources3
Beta strandi294 – 296Combined sources3
Helixi306 – 308Combined sources3
Helixi309 – 317Combined sources9
Helixi330 – 332Combined sources3
Turni337 – 339Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LFNX-ray2.10A/B/C/D23-359[»]
ProteinModelPortaliO15335.
SMRiO15335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 52LRRNTAdd BLAST30
Repeati76 – 97LRR 1Add BLAST22
Repeati100 – 121LRR 2Add BLAST22
Repeati124 – 145LRR 3Add BLAST22
Repeati148 – 169LRR 4Add BLAST22
Repeati172 – 193LRR 5Add BLAST22
Repeati196 – 217LRR 6Add BLAST22
Repeati220 – 241LRR 7Add BLAST22
Repeati245 – 266LRR 8Add BLAST22
Repeati269 – 290LRR 9Add BLAST22
Domaini300 – 348LRRCTAdd BLAST49

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000013150.
HOVERGENiHBG005324.
InParanoidiO15335.
KOiK06248.
OMAiAFRGCKF.
OrthoDBiEOG091G0AYL.
PhylomeDBiO15335.
TreeFamiTF332659.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
PfamiView protein in Pfam
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 10 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRPMLLLSL GLLAGLLPAL AACPQNCHCH SDLQHVICDK VGLQKIPKVS
60 70 80 90 100
EKTKLLNLQR NNFPVLAANS FRAMPNLVSL HLQHCQIREV AAGAFRGLKQ
110 120 130 140 150
LIYLYLSHND IRVLRAGAFD DLTELTYLYL DHNKVTELPR GLLSPLVNLF
160 170 180 190 200
ILQLNNNKIR ELRAGAFQGA KDLRWLYLSE NALSSLQPGA LDDVENLAKF
210 220 230 240 250
HVDRNQLSSY PSAALSKLRV VEELKLSHNP LKSIPDNAFQ SFGRYLETLW
260 270 280 290 300
LDNTNLEKFS DGAFLGVTTL KHVHLENNRL NQLPSNFPFD SLETLALTNN
310 320 330 340 350
PWKCTCQLRG LRRWLEAKAS RPDATCASPA KFKGQHIRDT DAFRSCKFPT

KRSKKAGRH
Length:359
Mass (Da):40,476
Last modified:February 20, 2007 - v2
Checksum:iCF24D2B5A5DFCF0C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114L → V in AAC13410 (PubMed:9344663).Curated1
Sequence conflicti166A → P in AAC13410 (PubMed:9344663).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052019312R → Q. Corresponds to variant dbSNP:rs35218093Ensembl.1
Natural variantiVAR_030631350T → I. Corresponds to variant dbSNP:rs2231510Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96769, U96767, U96768 Genomic DNA. Translation: AAC13410.1.
AF371328 mRNA. Translation: AAK51556.1.
AK292177 mRNA. Translation: BAF84866.1.
CH471109 Genomic DNA. Translation: EAW94613.1.
BC036360 mRNA. Translation: AAH36360.1.
BC073974 mRNA. Translation: AAH73974.1.
CCDSiCCDS11568.1.
RefSeqiNP_001258.2. NM_001267.2.
UniGeneiHs.97220.

Genome annotation databases

EnsembliENST00000258969; ENSP00000258969; ENSG00000136457.
ENST00000508540; ENSP00000423812; ENSG00000136457.
GeneIDi1101.
KEGGihsa:1101.
UCSCiuc010dbr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96769, U96767, U96768 Genomic DNA. Translation: AAC13410.1.
AF371328 mRNA. Translation: AAK51556.1.
AK292177 mRNA. Translation: BAF84866.1.
CH471109 Genomic DNA. Translation: EAW94613.1.
BC036360 mRNA. Translation: AAH36360.1.
BC073974 mRNA. Translation: AAH73974.1.
CCDSiCCDS11568.1.
RefSeqiNP_001258.2. NM_001267.2.
UniGeneiHs.97220.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LFNX-ray2.10A/B/C/D23-359[»]
ProteinModelPortaliO15335.
SMRiO15335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107526. 2 interactors.
STRINGi9606.ENSP00000258969.

PTM databases

PhosphoSitePlusiO15335.

Polymorphism and mutation databases

BioMutaiCHAD.

Proteomic databases

PaxDbiO15335.
PeptideAtlasiO15335.
PRIDEiO15335.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258969; ENSP00000258969; ENSG00000136457.
ENST00000508540; ENSP00000423812; ENSG00000136457.
GeneIDi1101.
KEGGihsa:1101.
UCSCiuc010dbr.4. human.

Organism-specific databases

CTDi1101.
DisGeNETi1101.
GeneCardsiCHAD.
HGNCiHGNC:1909. CHAD.
HPAiHPA018241.
MIMi602178. gene.
neXtProtiNX_O15335.
OpenTargetsiENSG00000136457.
PharmGKBiPA26445.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000013150.
HOVERGENiHBG005324.
InParanoidiO15335.
KOiK06248.
OMAiAFRGCKF.
OrthoDBiEOG091G0AYL.
PhylomeDBiO15335.
TreeFamiTF332659.

Miscellaneous databases

GenomeRNAii1101.
PROiO15335.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136457.
CleanExiHS_CHAD.
ExpressionAtlasiO15335. baseline and differential.
GenevisibleiO15335. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
PfamiView protein in Pfam
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 10 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCHAD_HUMAN
AccessioniPrimary (citable) accession number: O15335
Secondary accession number(s): A8K812, Q6GTU0, Q96RJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: February 20, 2007
Last modified: March 15, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.