Reviewed,
UniProtKB/Swiss-Prot O15327 (INP4B_HUMAN)
Last modified
June 16, 2009.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (6) |
 Third-party data |
 Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Type II inositol-3,4-bisphosphate 4-phosphatase EC=3.1.3.66 Alternative name(s): Inositol polyphosphate 4-phosphatase type II | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 924 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. |
| Catalytic activity | 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. |
| Enzyme regulation | Strongly inhibited by inositol hexakisphosphate By similarity. |
| Pathway | Signal transduction; phosphatidylinositol signaling pathway. |
| Tissue specificity | Widely expressed with highest levels occurring in the skeletal muscle and heart. Ref.1 |
| Sequence similarities | Belongs to the inositol-3,4-bisphosphate 4-phosphatase family. Contains 1 C2 domain. |
| Sequence caution | The sequence AAH72447.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Molecular function | Hydrolase |
| Gene Ontology (GO) | |
| Biological process | signal transduction Ref.1 Traceable author statement. Source: ProtInc |
| Molecular function | phosphatidyl-inositol-4,5-bisphosphate 4-phosphatase activity Inferred from electronic annotation. Source: EC phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Ref.1Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 924 | 924 | Type II inositol-3,4-bisphosphate 4-phosphatase | PRO_0000190235 | |||||
Regions | |||||||||
| Domain | 25 – 149 | 125 | C2 | ||||||
Natural variations | |||||||||
| Natural variant | 311 | 1 | Y → F: dbSNP rs1064226. Ref.1 | VAR_023324 | |||||
Experimental info | |||||||||
| Sequence conflict | 319 | 1 | S → A in AAB72153. Ref.1 | ||||||
| Sequence conflict | 683 | 1 | A → P in AAB72153. Ref.1 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family." Norris F.A., Atkins R.C., Majerus P.W. J. Biol. Chem. 272:23859-23864(1997) [PubMed: 9295334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT PHE-311. Tissue: Brain. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate and Skin. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U96922 mRNA. Translation: AAB72153.1. BC017924 mRNA. Translation: AAH17924.1. BC072447 mRNA. Translation: AAH72447.1. Sequence problems. | |
| IPI | IPI00022020. |
| RefSeq | NP_001095139.1. NP_003857.2. |
| UniGene | Hs.658245 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | O15327. |
Genome annotation databases | |
| Ensembl | ENSG00000109452. Homo sapiens. [Contig view] |
| GeneID | 8821. |
| KEGG | hsa:8821. |
Organism-specific databases | |
| GeneCards | GC04M143266. |
| HGNC | HGNC:6075. INPP4B. |
| MIM | 607494. gene. |
| PharmGKB | PA29883. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O15327. |
| HOVERGEN | O15327. |
| OMA | O15327. RMQVHSP. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.66. 247. |
Gene expression databases | |
| ArrayExpress | O15327. |
| Bgee | O15327. |
| CleanEx | HS_INPP4B. |
| GermOnline | ENSG00000109452. Homo sapiens. |
Family and domain databases | |
| PROSITE | PS50004. C2. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 33090. |
| SOURCE | Search... |
Entry information
| Entry name | INP4B_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O15327 Secondary accession number(s): Q6IN59, Q6PJB4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
