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Protein

Type II inositol 3,4-bisphosphate 4-phosphatase

Gene

INPP4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.

Catalytic activityi

1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

Enzyme regulationi

Strongly inhibited by inositol hexakisphosphate.By similarity

Pathwayi: phosphatidylinositol signaling pathway

This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:HS03227-MONOMER.
ZFISH:HS03227-MONOMER.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-1660516. Synthesis of PIPs at the early endosome membrane.
R-HSA-1855183. Synthesis of IP2, IP, and Ins in the cytosol.
UniPathwayiUPA00944.

Chemistry databases

SwissLipidsiSLP:000000898.

Names & Taxonomyi

Protein namesi
Recommended name:
Type II inositol 3,4-bisphosphate 4-phosphatase (EC:3.1.3.66)
Alternative name(s):
Inositol polyphosphate 4-phosphatase type II
Gene namesi
Name:INPP4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:6075. INPP4B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi8821.
OpenTargetsiENSG00000109452.
PharmGKBiPA29883.

Polymorphism and mutation databases

BioMutaiINPP4B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001902351 – 924Type II inositol 3,4-bisphosphate 4-phosphataseAdd BLAST924

Proteomic databases

MaxQBiO15327.
PaxDbiO15327.
PeptideAtlasiO15327.
PRIDEiO15327.

PTM databases

DEPODiO15327.
iPTMnetiO15327.
PhosphoSitePlusiO15327.

Expressioni

Tissue specificityi

Widely expressed with highest levels occurring in the skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiENSG00000109452.
CleanExiHS_INPP4B.
ExpressionAtlasiO15327. baseline and differential.
GenevisibleiO15327. HS.

Organism-specific databases

HPAiHPA037681.
HPA037682.

Interactioni

Protein-protein interaction databases

BioGridi114348. 2 interactors.
IntActiO15327. 1 interactor.
STRINGi9606.ENSP00000262992.

Structurei

3D structure databases

ProteinModelPortaliO15327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 149C2Add BLAST125

Sequence similaritiesi

Contains 1 C2 domain.Curated

Phylogenomic databases

eggNOGiKOG4428. Eukaryota.
ENOG410YV83. LUCA.
GeneTreeiENSGT00390000002033.
HOGENOMiHOG000113075.
HOVERGENiHBG081796.
InParanoidiO15327.
KOiK01109.
PhylomeDBiO15327.
TreeFamiTF325637.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15327-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIKEEGASE EGQHFLPTAQ ANDPGDCQFT SIQKTPNEPQ LEFILACKDL
60 70 80 90 100
VAPVRDRKLN TLVQISVIHP VEQSLTRYSS TEIVEGTRDP LFLTGVTFPS
110 120 130 140 150
EYPIYEETKI KLTVYDVKDK SHDTVRTSVL PEHKDPPPEV GRSFLGYASF
160 170 180 190 200
KVGELLKSKE QLLVLSLRTS DGGKVVGTIE VSVVKMGEIE DGEADHITTD
210 220 230 240 250
VQGQKCALVC ECTAPESVSG KDNLPFLNSV LKNPVCKLYR FPTSDNKWMR
260 270 280 290 300
IREQMSESIL SFHIPKELIS LHIKEDLCRN QEIKELGELS PHWDNLRKNV
310 320 330 340 350
LTHCDQMVNM YQDILTELSK ETGSSFKSSS SKGEKTLEFV PINLHLQRMQ
360 370 380 390 400
VHSPHLKDAL YDVITVGAPA AHFQGFKNGG LRKLLHRFET ERRNTGYQFI
410 420 430 440 450
YYSPENTAKA KEVLSNINQL QPLIATHADL LLNSASQHSP DSLKNSLKML
460 470 480 490 500
SEKTELFVHA FKDQLVRSAL LALYTARPGG ILKKPPSPKS STEESSPQDQ
510 520 530 540 550
PPVMRGQDSI PHHSDYDEEE WDRVWANVGK SLNCIIAMVD KLIERDGGSE
560 570 580 590 600
GSGGNNDGEK EPSLTDAIPS HPREDWYEQL YPLILTLKDC MGEVVNRAKQ
610 620 630 640 650
SLTFVLLQEL AYSLPQCLML TLRRDIVFSQ ALAGLVCGFI IKLQTSLYDP
660 670 680 690 700
GFLQQLHTVG LIVQYEGLLS TYSDEIGMLE DMAVGISDLK KVAFKIIEAK
710 720 730 740 750
SNDVLPVITG RREHYVVEVK LPARMFESLP LQIKEGQLLH VYPVLFNVGI
760 770 780 790 800
NEQQTLAERF GDVSLQESIN QENFELLQEY YKIFMEKMPP DYISHFQEQN
810 820 830 840 850
DLKALLENLL QNIQSKKRKN VEIMWLAATI CRKLNGIRFT CCKSAKDRTS
860 870 880 890 900
MSVTLEQCSI LRDEHQLHKD FFIRALDCMR REGCRIENVL KNIKCRKYAF
910 920
NMLQLMAFPK YYRPPEGTYG KADT
Length:924
Mass (Da):104,738
Last modified:December 16, 2008 - v4
Checksum:i57DE9D98E0168D41
GO
Isoform 2 (identifier: O15327-2) [UniParc]FASTAAdd to basket
Also known as: stubby

The sequence of this isoform differs from the canonical sequence as follows:
     125-131: VRTSVLP → IANSSRI
     132-924: Missing.

Show »
Length:131
Mass (Da):14,740
Checksum:iB194BF7E2BBCEC3A
GO

Sequence cautioni

The sequence AAH72447 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti319S → A in AAB72153 (PubMed:9295334).Curated1
Sequence conflicti683A → P in AAB72153 (PubMed:9295334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023324311Y → F.1 PublicationCorresponds to variant rs1064226dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047696125 – 131VRTSVLP → IANSSRI in isoform 2. 1 Publication7
Alternative sequenceiVSP_047697132 – 924Missing in isoform 2. 1 PublicationAdd BLAST793

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96922 mRNA. Translation: AAB72153.1.
AY753912 mRNA. Translation: AAV28485.1.
AC093860 Genomic DNA. No translation available.
AC093885 Genomic DNA. No translation available.
AC108060 Genomic DNA. No translation available.
AC108077 Genomic DNA. No translation available.
AC138657 Genomic DNA. No translation available.
AC139720 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05081.1.
BC017924 mRNA. Translation: AAH17924.1.
BC072447 mRNA. Translation: AAH72447.1. Sequence problems.
BC110918 mRNA. Translation: AAI10919.1.
BC133005 mRNA. Translation: AAI33006.1.
CCDSiCCDS3757.1. [O15327-1]
RefSeqiNP_001095139.1. NM_001101669.2. [O15327-1]
NP_001317969.1. NM_001331040.1.
NP_003857.2. NM_003866.3. [O15327-1]
UniGeneiHs.176376.
Hs.531403.
Hs.732573.

Genome annotation databases

EnsembliENST00000262992; ENSP00000262992; ENSG00000109452. [O15327-1]
ENST00000506217; ENSP00000424057; ENSG00000109452. [O15327-2]
ENST00000508116; ENSP00000423954; ENSG00000109452. [O15327-1]
ENST00000513000; ENSP00000425487; ENSG00000109452. [O15327-1]
GeneIDi8821.
KEGGihsa:8821.
UCSCiuc003iix.5. human. [O15327-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96922 mRNA. Translation: AAB72153.1.
AY753912 mRNA. Translation: AAV28485.1.
AC093860 Genomic DNA. No translation available.
AC093885 Genomic DNA. No translation available.
AC108060 Genomic DNA. No translation available.
AC108077 Genomic DNA. No translation available.
AC138657 Genomic DNA. No translation available.
AC139720 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05081.1.
BC017924 mRNA. Translation: AAH17924.1.
BC072447 mRNA. Translation: AAH72447.1. Sequence problems.
BC110918 mRNA. Translation: AAI10919.1.
BC133005 mRNA. Translation: AAI33006.1.
CCDSiCCDS3757.1. [O15327-1]
RefSeqiNP_001095139.1. NM_001101669.2. [O15327-1]
NP_001317969.1. NM_001331040.1.
NP_003857.2. NM_003866.3. [O15327-1]
UniGeneiHs.176376.
Hs.531403.
Hs.732573.

3D structure databases

ProteinModelPortaliO15327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114348. 2 interactors.
IntActiO15327. 1 interactor.
STRINGi9606.ENSP00000262992.

Chemistry databases

SwissLipidsiSLP:000000898.

PTM databases

DEPODiO15327.
iPTMnetiO15327.
PhosphoSitePlusiO15327.

Polymorphism and mutation databases

BioMutaiINPP4B.

Proteomic databases

MaxQBiO15327.
PaxDbiO15327.
PeptideAtlasiO15327.
PRIDEiO15327.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262992; ENSP00000262992; ENSG00000109452. [O15327-1]
ENST00000506217; ENSP00000424057; ENSG00000109452. [O15327-2]
ENST00000508116; ENSP00000423954; ENSG00000109452. [O15327-1]
ENST00000513000; ENSP00000425487; ENSG00000109452. [O15327-1]
GeneIDi8821.
KEGGihsa:8821.
UCSCiuc003iix.5. human. [O15327-1]

Organism-specific databases

CTDi8821.
DisGeNETi8821.
GeneCardsiINPP4B.
H-InvDBHIX0024592.
HGNCiHGNC:6075. INPP4B.
HPAiHPA037681.
HPA037682.
MIMi607494. gene.
neXtProtiNX_O15327.
OpenTargetsiENSG00000109452.
PharmGKBiPA29883.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4428. Eukaryota.
ENOG410YV83. LUCA.
GeneTreeiENSGT00390000002033.
HOGENOMiHOG000113075.
HOVERGENiHBG081796.
InParanoidiO15327.
KOiK01109.
PhylomeDBiO15327.
TreeFamiTF325637.

Enzyme and pathway databases

UniPathwayiUPA00944.
BioCyciMetaCyc:HS03227-MONOMER.
ZFISH:HS03227-MONOMER.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-1660516. Synthesis of PIPs at the early endosome membrane.
R-HSA-1855183. Synthesis of IP2, IP, and Ins in the cytosol.

Miscellaneous databases

ChiTaRSiINPP4B. human.
GeneWikiiINPP4B.
GenomeRNAii8821.
PROiO15327.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109452.
CleanExiHS_INPP4B.
ExpressionAtlasiO15327. baseline and differential.
GenevisibleiO15327. HS.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiINP4B_HUMAN
AccessioniPrimary (citable) accession number: O15327
Secondary accession number(s): Q2TAI2
, Q5XLE7, Q6IN59, Q6PJB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 16, 2008
Last modified: November 30, 2016
This is version 129 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.