O15327 (INP4B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type II inositol-3,4-bisphosphate 4-phosphatase
EC=3.1.3.66

Alternative name(s):
Inositol polyphosphate 4-phosphatase type II

Gene names

Name:

INPP4B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	924 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.
Catalytic activity	1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
Enzyme regulation	Strongly inhibited by inositol hexakisphosphate By similarity.
Pathway	Signal transduction; phosphatidylinositol signaling pathway.
Tissue specificity	Widely expressed with highest levels occurring in the skeletal muscle and heart. Ref.1
Sequence similarities	Belongs to the inositol-3,4-bisphosphate 4-phosphatase family. Contains 1 C2 domain.
Sequence caution	The sequence AAH72447.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	signal transduction Traceable author statement. Source: ProtInc
Molecular function	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Traceable author statement. Source: ProtInc phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 924	924	Type II inositol-3,4-bisphosphate 4-phosphatase		PRO_0000190235
Regions
	Domain	25 – 149	125	C2
Amino acid modifications
	Modified residue	487	1	Phosphoserine By similarity
Natural variations
	Natural variant	311	1	Y → F. Ref.1 Corresponds to variant rs1064226 [ dbSNP | Ensembl ].		VAR_023324
Experimental info
	Sequence conflict	319	1	S → A in AAB72153. Ref.1
	Sequence conflict	683	1	A → P in AAB72153. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O15327 [UniParc]. Last modified December 16, 2008. Version 4. Checksum: 57DE9D98E0168D41	FASTA	924	104,738
	10 20 30 40 50 60 MEIKEEGASE EGQHFLPTAQ ANDPGDCQFT SIQKTPNEPQ LEFILACKDL VAPVRDRKLN 70 80 90 100 110 120 TLVQISVIHP VEQSLTRYSS TEIVEGTRDP LFLTGVTFPS EYPIYEETKI KLTVYDVKDK 130 140 150 160 170 180 SHDTVRTSVL PEHKDPPPEV GRSFLGYASF KVGELLKSKE QLLVLSLRTS DGGKVVGTIE 190 200 210 220 230 240 VSVVKMGEIE DGEADHITTD VQGQKCALVC ECTAPESVSG KDNLPFLNSV LKNPVCKLYR 250 260 270 280 290 300 FPTSDNKWMR IREQMSESIL SFHIPKELIS LHIKEDLCRN QEIKELGELS PHWDNLRKNV 310 320 330 340 350 360 LTHCDQMVNM YQDILTELSK ETGSSFKSSS SKGEKTLEFV PINLHLQRMQ VHSPHLKDAL 370 380 390 400 410 420 YDVITVGAPA AHFQGFKNGG LRKLLHRFET ERRNTGYQFI YYSPENTAKA KEVLSNINQL 430 440 450 460 470 480 QPLIATHADL LLNSASQHSP DSLKNSLKML SEKTELFVHA FKDQLVRSAL LALYTARPGG 490 500 510 520 530 540 ILKKPPSPKS STEESSPQDQ PPVMRGQDSI PHHSDYDEEE WDRVWANVGK SLNCIIAMVD 550 560 570 580 590 600 KLIERDGGSE GSGGNNDGEK EPSLTDAIPS HPREDWYEQL YPLILTLKDC MGEVVNRAKQ 610 620 630 640 650 660 SLTFVLLQEL AYSLPQCLML TLRRDIVFSQ ALAGLVCGFI IKLQTSLYDP GFLQQLHTVG 670 680 690 700 710 720 LIVQYEGLLS TYSDEIGMLE DMAVGISDLK KVAFKIIEAK SNDVLPVITG RREHYVVEVK 730 740 750 760 770 780 LPARMFESLP LQIKEGQLLH VYPVLFNVGI NEQQTLAERF GDVSLQESIN QENFELLQEY 790 800 810 820 830 840 YKIFMEKMPP DYISHFQEQN DLKALLENLL QNIQSKKRKN VEIMWLAATI CRKLNGIRFT 850 860 870 880 890 900 CCKSAKDRTS MSVTLEQCSI LRDEHQLHKD FFIRALDCMR REGCRIENVL KNIKCRKYAF 910 920 NMLQLMAFPK YYRPPEGTYG KADT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family." Norris F.A., Atkins R.C., Majerus P.W. J. Biol. Chem. 272:23859-23864(1997) [PubMed: 9295334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT PHE-311. Tissue: Brain.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate and Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U96922 mRNA. Translation: AAB72153.1. CH471056 Genomic DNA. Translation: EAX05081.1. BC017924 mRNA. Translation: AAH17924.1. BC072447 mRNA. Translation: AAH72447.1. Sequence problems. BC110918 mRNA. Translation: AAI10919.1. BC133005 mRNA. Translation: AAI33006.1.
IPI	IPI00022020.
RefSeq	NP_001095139.1. NM_001101669.1. NP_003857.2. NM_003866.2.
UniGene	Hs.531403.
3D structure databases
ProteinModelPortal	O15327.
SMR	O15327. Positions 22-158.
ModBase	Search...
Protein-protein interaction databases
STRING	O15327.
PTM databases
PhosphoSite	O15327.
Proteomic databases
PRIDE	O15327.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262992; ENSP00000262992; ENSG00000109452.
GeneID	8821.
KEGG	hsa:8821.
Organism-specific databases
CTD	8821.
GeneCards	GC04M142949.
H-InvDB	HIX0024592.
HGNC	HGNC:6075. INPP4B.
HPA	HPA037681. HPA037682.
MIM	607494. gene.
neXtProt	NX_O15327.
PharmGKB	PA29883.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15850.
GeneTree	ENSGT00390000002033.
HOGENOM	HBG358151.
HOVERGEN	HBG081796.
InParanoid	O15327.
OMA	IPHHSDY.
PhylomeDB	O15327.
Enzyme and pathway databases
BioCyc	MetaCyc:ENSG00000109452-MONOMER.
Gene expression databases
ArrayExpress	O15327.
Bgee	O15327.
CleanEx	HS_INPP4B.
Genevestigator	O15327.
GermOnline	ENSG00000109452. Homo sapiens.
Family and domain databases
InterPro	IPR008973. C2_Ca/lipid-bd_dom_CaLB. [Graphical view]
KO	K01109.
SUPFAM	SSF49562. C2_CaLB. 1 hit.
PROSITE	PS50004. C2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	33090.
SOURCE	Search...

Entry information

Entry name

INP4B_HUMAN

Accession

Primary (citable) accession number: O15327
Secondary accession number(s): Q2TAI2, Q6IN59, Q6PJB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	December 16, 2008
Last modified:	January 25, 2012
This is version 84 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.