O15320 (CTGE5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cutaneous T-cell lymphoma-associated antigen 5
Short name=Protein cTAGE-5

Alternative name(s):
Meningioma-expressed antigen 6/11
cTAGE family member 5

Gene names

Name:	CTAGE5
Synonyms:	MEA11, MEA6, MGEA11, MGEA6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	804 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tumor-associated antigen.
Tissue specificity	Isoform 5A is expressed only in testis (at the protein level). Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 5B, but not isoform 5A, is expressed in head and neck squamous cell carcinoma.
Involvement in disease	Autoantibodies against CTAGE5 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).
Sequence similarities	Belongs to the cTAGE family.
Sequence caution	The sequence AAB86589.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	enzyme activator activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABL1	P00519	1	EBI-1050253,EBI-375543

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform MEA6 (identifier: O15320-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform MEA11 (identifier: O15320-2)

The sequence of this isoform differs from the canonical sequence as follows:
     514-556: Missing.

Note: No experimental confirmation available.

Isoform 5A (identifier: O15320-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Isoform 5B (identifier: O15320-4)

The sequence of this isoform differs from the canonical sequence as follows:
     750-771: MRNVYPPRGFPPYLPPRPGFFP → SARSPPGAGAPASGRGLGGPQK
     772-804: Missing.

Isoform 6 (identifier: O15320-5)

The sequence of this isoform differs from the canonical sequence as follows:
     128-128: E → EVENQM

Isoform 7 (identifier: O15320-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     128-128: E → EVENQM

Isoform 8 (identifier: O15320-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     515-557: Missing.

Isoform 9 (identifier: O15320-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 804	804	Cutaneous T-cell lymphoma-associated antigen 5		PRO_0000189541
Regions
	Coiled coil	87 – 273	187	Potential
	Coiled coil	321 – 501	181	Potential
	Compositional bias	502 – 804	303	Pro-rich
	Compositional bias	553 – 558	6	Poly-Gly
Amino acid modifications
	Modified residue	536	1	Phosphoserine By similarity
	Modified residue	548	1	Phosphoserine By similarity
	Modified residue	647	1	Phosphoserine By similarity
	Modified residue	678	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 80	80	Missing in isoform 7 and isoform 9.		VSP_035961
	Alternative sequence	1 – 29	29	Missing in isoform 5A and isoform 8.		VSP_012545
	Alternative sequence	128	1	E → EVENQM in isoform 6 and isoform 7.		VSP_035962
	Alternative sequence	514 – 556	43	Missing in isoform MEA11.		VSP_004322
	Alternative sequence	515 – 557	43	Missing in isoform 8.		VSP_035963
	Alternative sequence	750 – 771	22	MRNVY…PGFFP → SARSPPGAGAPASGRGLGGP QK in isoform 5B.		VSP_012546
	Alternative sequence	772 – 804	33	Missing in isoform 5B.		VSP_012547
	Natural variant	6	1	V → A. Ref.1 Ref.2 Corresponds to variant rs7140561 [ dbSNP | Ensembl ].		VAR_047889
	Natural variant	11	1	Y → D. Ref.7 Corresponds to variant rs17855895 [ dbSNP | Ensembl ].		VAR_047890
	Natural variant	205	1	K → N. Ref.7 Corresponds to variant rs17855896 [ dbSNP | Ensembl ].		VAR_047891
	Natural variant	250	1	K → E. Corresponds to variant rs10162564 [ dbSNP | Ensembl ].		VAR_047892
	Natural variant	360	1	E → Q. Ref.1 Ref.2 Ref.4 Corresponds to variant rs1950952 [ dbSNP | Ensembl ].		VAR_047893
	Natural variant	375	1	N → S. Corresponds to variant rs17109109 [ dbSNP | Ensembl ].		VAR_047894
	Natural variant	699	1	I → V. Ref.1 Ref.3 Ref.7 Corresponds to variant rs1140952 [ dbSNP | Ensembl ].		VAR_047895
	Natural variant	738	1	G → R. Ref.1 Ref.2 Ref.4 Corresponds to variant rs1060878 [ dbSNP | Ensembl ].		VAR_047896
Experimental info
	Sequence conflict	90	1	S → N in CAE45997. Ref.4
	Sequence conflict	145	1	I → M in CAE45997. Ref.4
	Sequence conflict	195	1	K → Q in AAB86593. Ref.1
	Sequence conflict	195	1	K → Q in AAB86589. Ref.1
	Sequence conflict	198	1	Q → P in AAB86593. Ref.1
	Sequence conflict	546	1	R → T in AAB86593. Ref.1
	Sequence conflict	589	1	P → L in AAB86593. Ref.1
	Sequence conflict	594	1	S → F in AAB86593. Ref.1
	Sequence conflict	604	1	R → M in AAN77610. Ref.2
	Sequence conflict	776	1	S → F in AAN77610. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform MEA6 [UniParc]. Last modified November 2, 2010. Version 4. Checksum: EB2CAC59C4ED7867	FASTA	804	90,996
	10 20 30 40 50 60 MEEPGVTPQP YLGLLLEELR RVVAALPEGM RPDSNLYGFP WELVICAAVV GFFAVLFFLW 70 80 90 100 110 120 RSFRSVRSRL YVGREKKLAL MLSGLIEEKS KLLEKFSLVQ KEYEGYEVES SLKDASFEKE 130 140 150 160 170 180 ATEAQSLEAT CEKLNRSNSE LEDEILCLEK ELKEEKSKHS EQDELMADIS KRIQSLEDES 190 200 210 220 230 240 KSLKSQVAEA KMTFKIFQMN EERLKIAIKD ALNENSQLQE SQKQLLQEAE VWKEQVSELN 250 260 270 280 290 300 KQKVTFEDSK VHAEQVLNDK ESHIKTLTER LLKMKDWAAM LGEDITDDDN LELEMNSESE 310 320 330 340 350 360 NGAYLDNPPK GALKKLIHAA KLNASLKTLE GERNQIYIQL SEVDKTKEEL TEHIKNLQTE 370 380 390 400 410 420 QASLQSENTH FENENQKLQQ KLKVMTELYQ ENEMKLHRKL TVEENYRLEK EEKLSKVDEK 430 440 450 460 470 480 ISHATEELET YRKRAKDLEE ELERTIHSYQ GQIISHEKKA HDNWLAARNA ERNLNDLRKE 490 500 510 520 530 540 NAHNRQKLTE TELKFELLEK DPYALDVPNT AFGREHSPYG PSPLGWPSSE TRAFLSPPTL 550 560 570 580 590 600 LEGPLRLSPL LPGGGGRGSR GPGNPLDHQI TNERGESSCD RLTDPHRAPS DTGSLSPPWD 610 620 630 640 650 660 QDRRMMFPPP GQSYPDSALP PQRQDRFCSN SGRLSGPAEL RSFNMPSLDK MDGSMPSEME 670 680 690 700 710 720 SSRNDTKDDL GNLNVPDSSL PAENEATGPG FVPPPLAPIR GPLFPVDARG PFLRRGPPFP 730 740 750 760 770 780 PPPPGAMFGA SRDYFPPGDF PGPPPAPFAM RNVYPPRGFP PYLPPRPGFF PPPPHSEGRS 790 800 EFPSGLIPPS NEPATEHPEP QQET
	Isoform MEA11 [UniParc]. Checksum: B101FD49659A2F30	FASTA	761	86,532
	10 20 30 40 50 60 MEEPGVTPQP YLGLLLEELR RVVAALPEGM RPDSNLYGFP WELVICAAVV GFFAVLFFLW 70 80 90 100 110 120 RSFRSVRSRL YVGREKKLAL MLSGLIEEKS KLLEKFSLVQ KEYEGYEVES SLKDASFEKE 130 140 150 160 170 180 ATEAQSLEAT CEKLNRSNSE LEDEILCLEK ELKEEKSKHS EQDELMADIS KRIQSLEDES 190 200 210 220 230 240 KSLKSQVAEA KMTFKIFQMN EERLKIAIKD ALNENSQLQE SQKQLLQEAE VWKEQVSELN 250 260 270 280 290 300 KQKVTFEDSK VHAEQVLNDK ESHIKTLTER LLKMKDWAAM LGEDITDDDN LELEMNSESE 310 320 330 340 350 360 NGAYLDNPPK GALKKLIHAA KLNASLKTLE GERNQIYIQL SEVDKTKEEL TEHIKNLQTE 370 380 390 400 410 420 QASLQSENTH FENENQKLQQ KLKVMTELYQ ENEMKLHRKL TVEENYRLEK EEKLSKVDEK 430 440 450 460 470 480 ISHATEELET YRKRAKDLEE ELERTIHSYQ GQIISHEKKA HDNWLAARNA ERNLNDLRKE 490 500 510 520 530 540 NAHNRQKLTE TELKFELLEK DPYALDVPNT AFGRGSRGPG NPLDHQITNE RGESSCDRLT 550 560 570 580 590 600 DPHRAPSDTG SLSPPWDQDR RMMFPPPGQS YPDSALPPQR QDRFCSNSGR LSGPAELRSF 610 620 630 640 650 660 NMPSLDKMDG SMPSEMESSR NDTKDDLGNL NVPDSSLPAE NEATGPGFVP PPLAPIRGPL 670 680 690 700 710 720 FPVDARGPFL RRGPPFPPPP PGAMFGASRD YFPPGDFPGP PPAPFAMRNV YPPRGFPPYL 730 740 750 760 PPRPGFFPPP PHSEGRSEFP SGLIPPSNEP ATEHPEPQQE T
	Isoform 5A [UniParc]. Checksum: 46C11CD859A408FF	FASTA	775	87,837
	10 20 30 40 50 60 MRPDSNLYGF PWELVICAAV VGFFAVLFFL WRSFRSVRSR LYVGREKKLA LMLSGLIEEK 70 80 90 100 110 120 SKLLEKFSLV QKEYEGYEVE SSLKDASFEK EATEAQSLEA TCEKLNRSNS ELEDEILCLE 130 140 150 160 170 180 KELKEEKSKH SEQDELMADI SKRIQSLEDE SKSLKSQVAE AKMTFKIFQM NEERLKIAIK 190 200 210 220 230 240 DALNENSQLQ ESQKQLLQEA EVWKEQVSEL NKQKVTFEDS KVHAEQVLND KESHIKTLTE 250 260 270 280 290 300 RLLKMKDWAA MLGEDITDDD NLELEMNSES ENGAYLDNPP KGALKKLIHA AKLNASLKTL 310 320 330 340 350 360 EGERNQIYIQ LSEVDKTKEE LTEHIKNLQT EQASLQSENT HFENENQKLQ QKLKVMTELY 370 380 390 400 410 420 QENEMKLHRK LTVEENYRLE KEEKLSKVDE KISHATEELE TYRKRAKDLE EELERTIHSY 430 440 450 460 470 480 QGQIISHEKK AHDNWLAARN AERNLNDLRK ENAHNRQKLT ETELKFELLE KDPYALDVPN 490 500 510 520 530 540 TAFGREHSPY GPSPLGWPSS ETRAFLSPPT LLEGPLRLSP LLPGGGGRGS RGPGNPLDHQ 550 560 570 580 590 600 ITNERGESSC DRLTDPHRAP SDTGSLSPPW DQDRRMMFPP PGQSYPDSAL PPQRQDRFCS 610 620 630 640 650 660 NSGRLSGPAE LRSFNMPSLD KMDGSMPSEM ESSRNDTKDD LGNLNVPDSS LPAENEATGP 670 680 690 700 710 720 GFVPPPLAPI RGPLFPVDAR GPFLRRGPPF PPPPPGAMFG ASRDYFPPGD FPGPPPAPFA 730 740 750 760 770 MRNVYPPRGF PPYLPPRPGF FPPPPHSEGR SEFPSGLIPP SNEPATEHPE PQQET
	Isoform 5B [UniParc]. Checksum: 2E5D4546606E6EC3	FASTA	771	86,811
	10 20 30 40 50 60 MEEPGVTPQP YLGLLLEELR RVVAALPEGM RPDSNLYGFP WELVICAAVV GFFAVLFFLW 70 80 90 100 110 120 RSFRSVRSRL YVGREKKLAL MLSGLIEEKS KLLEKFSLVQ KEYEGYEVES SLKDASFEKE 130 140 150 160 170 180 ATEAQSLEAT CEKLNRSNSE LEDEILCLEK ELKEEKSKHS EQDELMADIS KRIQSLEDES 190 200 210 220 230 240 KSLKSQVAEA KMTFKIFQMN EERLKIAIKD ALNENSQLQE SQKQLLQEAE VWKEQVSELN 250 260 270 280 290 300 KQKVTFEDSK VHAEQVLNDK ESHIKTLTER LLKMKDWAAM LGEDITDDDN LELEMNSESE 310 320 330 340 350 360 NGAYLDNPPK GALKKLIHAA KLNASLKTLE GERNQIYIQL SEVDKTKEEL TEHIKNLQTE 370 380 390 400 410 420 QASLQSENTH FENENQKLQQ KLKVMTELYQ ENEMKLHRKL TVEENYRLEK EEKLSKVDEK 430 440 450 460 470 480 ISHATEELET YRKRAKDLEE ELERTIHSYQ GQIISHEKKA HDNWLAARNA ERNLNDLRKE 490 500 510 520 530 540 NAHNRQKLTE TELKFELLEK DPYALDVPNT AFGREHSPYG PSPLGWPSSE TRAFLSPPTL 550 560 570 580 590 600 LEGPLRLSPL LPGGGGRGSR GPGNPLDHQI TNERGESSCD RLTDPHRAPS DTGSLSPPWD 610 620 630 640 650 660 QDRRMMFPPP GQSYPDSALP PQRQDRFCSN SGRLSGPAEL RSFNMPSLDK MDGSMPSEME 670 680 690 700 710 720 SSRNDTKDDL GNLNVPDSSL PAENEATGPG FVPPPLAPIR GPLFPVDARG PFLRRGPPFP 730 740 750 760 770 PPPPGAMFGA SRDYFPPGDF PGPPPAPFAS ARSPPGAGAP ASGRGLGGPQ K
	Isoform 6 [UniParc]. Checksum: 93E6E1B2E908306B	FASTA	809	91,598
	10 20 30 40 50 60 MEEPGVTPQP YLGLLLEELR RVVAALPEGM RPDSNLYGFP WELVICAAVV GFFAVLFFLW 70 80 90 100 110 120 RSFRSVRSRL YVGREKKLAL MLSGLIEEKS KLLEKFSLVQ KEYEGYEVES SLKDASFEKE 130 140 150 160 170 180 ATEAQSLEVE NQMATCEKLN RSNSELEDEI LCLEKELKEE KSKHSEQDEL MADISKRIQS 190 200 210 220 230 240 LEDESKSLKS QVAEAKMTFK IFQMNEERLK IAIKDALNEN SQLQESQKQL LQEAEVWKEQ 250 260 270 280 290 300 VSELNKQKVT FEDSKVHAEQ VLNDKESHIK TLTERLLKMK DWAAMLGEDI TDDDNLELEM 310 320 330 340 350 360 NSESENGAYL DNPPKGALKK LIHAAKLNAS LKTLEGERNQ IYIQLSEVDK TKEELTEHIK 370 380 390 400 410 420 NLQTEQASLQ SENTHFENEN QKLQQKLKVM TELYQENEMK LHRKLTVEEN YRLEKEEKLS 430 440 450 460 470 480 KVDEKISHAT EELETYRKRA KDLEEELERT IHSYQGQIIS HEKKAHDNWL AARNAERNLN 490 500 510 520 530 540 DLRKENAHNR QKLTETELKF ELLEKDPYAL DVPNTAFGRE HSPYGPSPLG WPSSETRAFL 550 560 570 580 590 600 SPPTLLEGPL RLSPLLPGGG GRGSRGPGNP LDHQITNERG ESSCDRLTDP HRAPSDTGSL 610 620 630 640 650 660 SPPWDQDRRM MFPPPGQSYP DSALPPQRQD RFCSNSGRLS GPAELRSFNM PSLDKMDGSM 670 680 690 700 710 720 PSEMESSRND TKDDLGNLNV PDSSLPAENE ATGPGFVPPP LAPIRGPLFP VDARGPFLRR 730 740 750 760 770 780 GPPFPPPPPG AMFGASRDYF PPGDFPGPPP APFAMRNVYP PRGFPPYLPP RPGFFPPPPH 790 800 SEGRSEFPSG LIPPSNEPAT EHPEPQQET
	Isoform 7 [UniParc]. Checksum: 31620F247C9CF9A1	FASTA	729	82,443
	10 20 30 40 50 60 MLSGLIEEKS KLLEKFSLVQ KEYEGYEVES SLKDASFEKE ATEAQSLEVE NQMATCEKLN 70 80 90 100 110 120 RSNSELEDEI LCLEKELKEE KSKHSEQDEL MADISKRIQS LEDESKSLKS QVAEAKMTFK 130 140 150 160 170 180 IFQMNEERLK IAIKDALNEN SQLQESQKQL LQEAEVWKEQ VSELNKQKVT FEDSKVHAEQ 190 200 210 220 230 240 VLNDKESHIK TLTERLLKMK DWAAMLGEDI TDDDNLELEM NSESENGAYL DNPPKGALKK 250 260 270 280 290 300 LIHAAKLNAS LKTLEGERNQ IYIQLSEVDK TKEELTEHIK NLQTEQASLQ SENTHFENEN 310 320 330 340 350 360 QKLQQKLKVM TELYQENEMK LHRKLTVEEN YRLEKEEKLS KVDEKISHAT EELETYRKRA 370 380 390 400 410 420 KDLEEELERT IHSYQGQIIS HEKKAHDNWL AARNAERNLN DLRKENAHNR QKLTETELKF 430 440 450 460 470 480 ELLEKDPYAL DVPNTAFGRE HSPYGPSPLG WPSSETRAFL SPPTLLEGPL RLSPLLPGGG 490 500 510 520 530 540 GRGSRGPGNP LDHQITNERG ESSCDRLTDP HRAPSDTGSL SPPWDQDRRM MFPPPGQSYP 550 560 570 580 590 600 DSALPPQRQD RFCSNSGRLS GPAELRSFNM PSLDKMDGSM PSEMESSRND TKDDLGNLNV 610 620 630 640 650 660 PDSSLPAENE ATGPGFVPPP LAPIRGPLFP VDARGPFLRR GPPFPPPPPG AMFGASRDYF 670 680 690 700 710 720 PPGDFPGPPP APFAMRNVYP PRGFPPYLPP RPGFFPPPPH SEGRSEFPSG LIPPSNEPAT EHPEPQQET
	Isoform 8 [UniParc]. Checksum: 3A7C4AC2B3D65396	FASTA	732	83,373
	10 20 30 40 50 60 MRPDSNLYGF PWELVICAAV VGFFAVLFFL WRSFRSVRSR LYVGREKKLA LMLSGLIEEK 70 80 90 100 110 120 SKLLEKFSLV QKEYEGYEVE SSLKDASFEK EATEAQSLEA TCEKLNRSNS ELEDEILCLE 130 140 150 160 170 180 KELKEEKSKH SEQDELMADI SKRIQSLEDE SKSLKSQVAE AKMTFKIFQM NEERLKIAIK 190 200 210 220 230 240 DALNENSQLQ ESQKQLLQEA EVWKEQVSEL NKQKVTFEDS KVHAEQVLND KESHIKTLTE 250 260 270 280 290 300 RLLKMKDWAA MLGEDITDDD NLELEMNSES ENGAYLDNPP KGALKKLIHA AKLNASLKTL 310 320 330 340 350 360 EGERNQIYIQ LSEVDKTKEE LTEHIKNLQT EQASLQSENT HFENENQKLQ QKLKVMTELY 370 380 390 400 410 420 QENEMKLHRK LTVEENYRLE KEEKLSKVDE KISHATEELE TYRKRAKDLE EELERTIHSY 430 440 450 460 470 480 QGQIISHEKK AHDNWLAARN AERNLNDLRK ENAHNRQKLT ETELKFELLE KDPYALDVPN 490 500 510 520 530 540 TAFGRGSRGP GNPLDHQITN ERGESSCDRL TDPHRAPSDT GSLSPPWDQD RRMMFPPPGQ 550 560 570 580 590 600 SYPDSALPPQ RQDRFCSNSG RLSGPAELRS FNMPSLDKMD GSMPSEMESS RNDTKDDLGN 610 620 630 640 650 660 LNVPDSSLPA ENEATGPGFV PPPLAPIRGP LFPVDARGPF LRRGPPFPPP PPGAMFGASR 670 680 690 700 710 720 DYFPPGDFPG PPPAPFAMRN VYPPRGFPPY LPPRPGFFPP PPHSEGRSEF PSGLIPPSNE 730 PATEHPEPQQ ET
	Isoform 9 [UniParc]. Checksum: AFE56681C351F234	FASTA	724	81,841
	10 20 30 40 50 60 MLSGLIEEKS KLLEKFSLVQ KEYEGYEVES SLKDASFEKE ATEAQSLEAT CEKLNRSNSE 70 80 90 100 110 120 LEDEILCLEK ELKEEKSKHS EQDELMADIS KRIQSLEDES KSLKSQVAEA KMTFKIFQMN 130 140 150 160 170 180 EERLKIAIKD ALNENSQLQE SQKQLLQEAE VWKEQVSELN KQKVTFEDSK VHAEQVLNDK 190 200 210 220 230 240 ESHIKTLTER LLKMKDWAAM LGEDITDDDN LELEMNSESE NGAYLDNPPK GALKKLIHAA 250 260 270 280 290 300 KLNASLKTLE GERNQIYIQL SEVDKTKEEL TEHIKNLQTE QASLQSENTH FENENQKLQQ 310 320 330 340 350 360 KLKVMTELYQ ENEMKLHRKL TVEENYRLEK EEKLSKVDEK ISHATEELET YRKRAKDLEE 370 380 390 400 410 420 ELERTIHSYQ GQIISHEKKA HDNWLAARNA ERNLNDLRKE NAHNRQKLTE TELKFELLEK 430 440 450 460 470 480 DPYALDVPNT AFGREHSPYG PSPLGWPSSE TRAFLSPPTL LEGPLRLSPL LPGGGGRGSR 490 500 510 520 530 540 GPGNPLDHQI TNERGESSCD RLTDPHRAPS DTGSLSPPWD QDRRMMFPPP GQSYPDSALP 550 560 570 580 590 600 PQRQDRFCSN SGRLSGPAEL RSFNMPSLDK MDGSMPSEME SSRNDTKDDL GNLNVPDSSL 610 620 630 640 650 660 PAENEATGPG FVPPPLAPIR GPLFPVDARG PFLRRGPPFP PPPPGAMFGA SRDYFPPGDF 670 680 690 700 710 720 PGPPPAPFAM RNVYPPRGFP PYLPPRPGFF PPPPHSEGRS EFPSGLIPPS NEPATEHPEP QQET

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning and chromosomal mapping of a predicted coiled-coil proline-rich protein immunogenic in meningioma patients." Heckel D., Brass N., Fischer U., Blin N., Steudel I., Tuereci O., Fackler O., Zang K.D., Meese E. Hum. Mol. Genet. 6:2031-2041(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MEA6 AND MEA11), VARIANTS ALA-6; GLN-360; VAL-699 AND ARG-738. Tissue: Meningioma.
[2]	"cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing." Usener D., Schadendorf D., Koch J., Duebel S., Eichmueller S. J. Invest. Dermatol. 121:198-206(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5A AND 5B), VARIANTS ALA-6; GLN-360 AND ARG-738. Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8), VARIANT VAL-699. Tissue: Tongue.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9), VARIANTS GLN-360 AND ARG-738. Tissue: Salivary gland.
[5]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7), VARIANTS ASP-11; ASN-205 AND VAL-699. Tissue: B-cell and Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U73682 mRNA. Translation: AAB86589.1. Different initiation. U94780 mRNA. Translation: AAB86593.1. AF338233 mRNA. Translation: AAN77610.1. AF338234 mRNA. Translation: AAN77611.1. AK091252 mRNA. Translation: BAG52318.1. BX640994 mRNA. Translation: CAE45997.1. AL132639 Genomic DNA. No translation available. CH471078 Genomic DNA. Translation: EAW65808.1. CH471078 Genomic DNA. Translation: EAW65812.1. CH471078 Genomic DNA. Translation: EAW65813.1. BC051363 mRNA. Translation: AAH51363.2. BC064355 mRNA. Translation: AAH64355.1.
IPI	IPI00006122. IPI00218139. IPI00401163. IPI00515009. IPI00872345. IPI00915283. IPI00915291. IPI00915443.
RefSeq	NP_001234917.1. NM_001247988.1. NP_001234918.1. NM_001247989.1. NP_001234919.1. NM_001247990.1. NP_005921.2. NM_005930.3. NP_976231.1. NM_203356.2.
UniGene	Hs.509200. Hs.540038. Hs.741763.
3D structure databases
ProteinModelPortal	O15320.
ModBase	Search...
Protein-protein interaction databases
IntAct	O15320. 4 interactions.
MINT	MINT-4526262.
PTM databases
PhosphoSite	O15320.
Proteomic databases
PaxDb	O15320.
PRIDE	O15320.
Protocols and materials databases
DNASU	4253.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000280083; ENSP00000280083; ENSG00000150527. ENST00000341502; ENSP00000339286; ENSG00000150527. ENST00000348007; ENSP00000343912; ENSG00000150527. ENST00000396158; ENSP00000379462; ENSG00000150527. ENST00000396165; ENSP00000379468; ENSG00000150527. ENST00000553352; ENSP00000450449; ENSG00000150527. ENST00000556148; ENSP00000452562; ENSG00000150527. ENST00000557038; ENSP00000450869; ENSG00000150527.
GeneID	4253.
KEGG	hsa:4253.
UCSC	uc001wuy.4. human. uc001wvb.4. human. uc001wvf.4. human. uc001wvh.4. human. uc001wvi.4. human.
Organism-specific databases
CTD	4253.
GeneCards	GC14P039734.
H-InvDB	HIX0021193.
HGNC	HGNC:7057. CTAGE5.
HPA	HPA000387. HPA000922.
MIM	602132. gene.
neXtProt	NX_O15320.
PharmGKB	PA30788.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG133684.
HOVERGEN	HBG051216.
InParanoid	O15320.
PhylomeDB	O15320.
Gene expression databases
ArrayExpress	O15320.
Bgee	O15320.
CleanEx	HS_CTAGE5.
Genevestigator	O15320.
GermOnline	ENSG00000150527. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	4253.
NextBio	16763.
SOURCE	Search...

Entry information

Entry name

CTGE5_HUMAN

Accession

Primary (citable) accession number: O15320
Secondary accession number(s): B3KRA6 , D3DSA6, O00169, Q6MZN2, Q6P2R8, Q86TF6, Q8IX92, Q8IX93

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 2, 2010
Last modified:	April 3, 2013
This is version 109 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.