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O15320 (CTGE5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
cTAGE family member 5

Short name=Protein cTAGE-5
Alternative name(s):
Meningioma-expressed antigen 6/11
Gene names
Name:CTAGE5
Synonyms:MEA11, MEA6, MGEA11, MGEA6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length804 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tumor-associated antigen.

Tissue specificity

Isoform 5A is expressed only in testis (at the protein level). Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 5B, but not isoform 5A, is expressed in head and neck squamous cell carcinoma.

Involvement in disease

Autoantibodies against CTAGE5 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).

Sequence similarities

Belongs to the cTAGE family.

Sequence caution

The sequence AAB86589.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpositive regulation of catalytic activity

Traceable author statement Ref.1. Source: GOC

   Molecular_functionenzyme activator activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ABL1P005191EBI-1050253,EBI-375543

Alternative products

This entry describes 10 isoforms produced by alternative splicing. [Align] [Select]
Isoform MEA6 (identifier: O15320-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform MEA11 (identifier: O15320-2)

The sequence of this isoform differs from the canonical sequence as follows:
     514-556: Missing.
Note: No experimental confirmation available.
Isoform 5A (identifier: O15320-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
Isoform 5B (identifier: O15320-4)

The sequence of this isoform differs from the canonical sequence as follows:
     750-771: MRNVYPPRGFPPYLPPRPGFFP → SARSPPGAGAPASGRGLGGPQK
     772-804: Missing.
Isoform 6 (identifier: O15320-5)

The sequence of this isoform differs from the canonical sequence as follows:
     128-128: E → EVENQM
Isoform 7 (identifier: O15320-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     128-128: E → EVENQM
Isoform 8 (identifier: O15320-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     515-557: Missing.
Isoform 9 (identifier: O15320-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
Isoform 10 (identifier: O15320-9)

The sequence of this isoform differs from the canonical sequence as follows:
     3-21: EPGVTPQPYLGLLLEELRR → LKSPEEE
     103-128: Missing.
     647-717: Missing.
     725-747: Missing.
Isoform 11 (identifier: O15320-10)

The sequence of this isoform differs from the canonical sequence as follows:
     3-21: EPGVTPQPYLGLLLEELRR → LKSPEEE
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 804804cTAGE family member 5
PRO_0000189541

Regions

Coiled coil87 – 273187 Potential
Coiled coil321 – 501181 Potential
Compositional bias502 – 804303Pro-rich
Compositional bias553 – 5586Poly-Gly

Amino acid modifications

Modified residue5361Phosphoserine By similarity
Modified residue5481Phosphoserine By similarity
Modified residue6781Phosphoserine By similarity

Natural variations

Alternative sequence1 – 8080Missing in isoform 7 and isoform 9.
VSP_035961
Alternative sequence1 – 2929Missing in isoform 5A and isoform 8.
VSP_012545
Alternative sequence3 – 2119EPGVT…EELRR → LKSPEEE in isoform 10 and isoform 11.
VSP_047234
Alternative sequence103 – 12826Missing in isoform 10.
VSP_047235
Alternative sequence1281E → EVENQM in isoform 6 and isoform 7.
VSP_035962
Alternative sequence514 – 55643Missing in isoform MEA11.
VSP_004322
Alternative sequence515 – 55743Missing in isoform 8.
VSP_035963
Alternative sequence647 – 71771Missing in isoform 10.
VSP_047236
Alternative sequence725 – 74723Missing in isoform 10.
VSP_047237
Alternative sequence750 – 77122MRNVY…PGFFP → SARSPPGAGAPASGRGLGGP QK in isoform 5B.
VSP_012546
Alternative sequence772 – 80433Missing in isoform 5B.
VSP_012547
Natural variant61V → A. Ref.1 Ref.2
Corresponds to variant rs7140561 [ dbSNP | Ensembl ].
VAR_047889
Natural variant111Y → D. Ref.7
Corresponds to variant rs17855895 [ dbSNP | Ensembl ].
VAR_047890
Natural variant2051K → N. Ref.7
Corresponds to variant rs17855896 [ dbSNP | Ensembl ].
VAR_047891
Natural variant2501K → E.
Corresponds to variant rs10162564 [ dbSNP | Ensembl ].
VAR_047892
Natural variant3601E → Q. Ref.1 Ref.2 Ref.3 Ref.4
Corresponds to variant rs1950952 [ dbSNP | Ensembl ].
VAR_047893
Natural variant3751N → S.
Corresponds to variant rs17109109 [ dbSNP | Ensembl ].
VAR_047894
Natural variant6991I → V. Ref.1 Ref.3 Ref.7
Corresponds to variant rs1140952 [ dbSNP | Ensembl ].
VAR_047895
Natural variant7381G → R. Ref.1 Ref.2 Ref.4
Corresponds to variant rs1060878 [ dbSNP | Ensembl ].
VAR_047896

Experimental info

Sequence conflict901S → N in CAE45997. Ref.4
Sequence conflict1451I → M in CAE45997. Ref.4
Sequence conflict1951K → Q in AAB86593. Ref.1
Sequence conflict1951K → Q in AAB86589. Ref.1
Sequence conflict1981Q → P in AAB86593. Ref.1
Sequence conflict5461R → T in AAB86593. Ref.1
Sequence conflict5891P → L in AAB86593. Ref.1
Sequence conflict5941S → F in AAB86593. Ref.1
Sequence conflict6041R → M in AAN77610. Ref.2
Sequence conflict7761S → F in AAN77610. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform MEA6 [UniParc].

Last modified November 2, 2010. Version 4.
Checksum: EB2CAC59C4ED7867

FASTA80490,996
        10         20         30         40         50         60 
MEEPGVTPQP YLGLLLEELR RVVAALPEGM RPDSNLYGFP WELVICAAVV GFFAVLFFLW 

        70         80         90        100        110        120 
RSFRSVRSRL YVGREKKLAL MLSGLIEEKS KLLEKFSLVQ KEYEGYEVES SLKDASFEKE 

       130        140        150        160        170        180 
ATEAQSLEAT CEKLNRSNSE LEDEILCLEK ELKEEKSKHS EQDELMADIS KRIQSLEDES 

       190        200        210        220        230        240 
KSLKSQVAEA KMTFKIFQMN EERLKIAIKD ALNENSQLQE SQKQLLQEAE VWKEQVSELN 

       250        260        270        280        290        300 
KQKVTFEDSK VHAEQVLNDK ESHIKTLTER LLKMKDWAAM LGEDITDDDN LELEMNSESE 

       310        320        330        340        350        360 
NGAYLDNPPK GALKKLIHAA KLNASLKTLE GERNQIYIQL SEVDKTKEEL TEHIKNLQTE 

       370        380        390        400        410        420 
QASLQSENTH FENENQKLQQ KLKVMTELYQ ENEMKLHRKL TVEENYRLEK EEKLSKVDEK 

       430        440        450        460        470        480 
ISHATEELET YRKRAKDLEE ELERTIHSYQ GQIISHEKKA HDNWLAARNA ERNLNDLRKE 

       490        500        510        520        530        540 
NAHNRQKLTE TELKFELLEK DPYALDVPNT AFGREHSPYG PSPLGWPSSE TRAFLSPPTL 

       550        560        570        580        590        600 
LEGPLRLSPL LPGGGGRGSR GPGNPLDHQI TNERGESSCD RLTDPHRAPS DTGSLSPPWD 

       610        620        630        640        650        660 
QDRRMMFPPP GQSYPDSALP PQRQDRFCSN SGRLSGPAEL RSFNMPSLDK MDGSMPSEME 

       670        680        690        700        710        720 
SSRNDTKDDL GNLNVPDSSL PAENEATGPG FVPPPLAPIR GPLFPVDARG PFLRRGPPFP 

       730        740        750        760        770        780 
PPPPGAMFGA SRDYFPPGDF PGPPPAPFAM RNVYPPRGFP PYLPPRPGFF PPPPHSEGRS 

       790        800 
EFPSGLIPPS NEPATEHPEP QQET 

« Hide

Isoform MEA11 [UniParc].

Checksum: B101FD49659A2F30
Show »

FASTA76186,532
Isoform 5A [UniParc].

Checksum: 46C11CD859A408FF
Show »

FASTA77587,837
Isoform 5B [UniParc].

Checksum: 2E5D4546606E6EC3
Show »

FASTA77186,811
Isoform 6 [UniParc].

Checksum: 93E6E1B2E908306B
Show »

FASTA80991,598
Isoform 7 [UniParc].

Checksum: 31620F247C9CF9A1
Show »

FASTA72982,443
Isoform 8 [UniParc].

Checksum: 3A7C4AC2B3D65396
Show »

FASTA73283,373
Isoform 9 [UniParc].

Checksum: AFE56681C351F234
Show »

FASTA72481,841
Isoform 10 [UniParc].

Checksum: CA742CB43201E4FE
Show »

FASTA67276,880
Isoform 11 [UniParc].

Checksum: 0C9C6951D420A590
Show »

FASTA79289,647

References

« Hide 'large scale' references
[1]"cDNA cloning and chromosomal mapping of a predicted coiled-coil proline-rich protein immunogenic in meningioma patients."
Heckel D., Brass N., Fischer U., Blin N., Steudel I., Tuereci O., Fackler O., Zang K.D., Meese E.
Hum. Mol. Genet. 6:2031-2041(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MEA6 AND MEA11), VARIANTS ALA-6; GLN-360; VAL-699 AND ARG-738.
Tissue: Meningioma.
[2]"cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing."
Usener D., Schadendorf D., Koch J., Duebel S., Eichmueller S.
J. Invest. Dermatol. 121:198-206(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5A AND 5B), VARIANTS ALA-6; GLN-360 AND ARG-738.
Tissue: Testis.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 8 AND 10), VARIANTS GLN-360 AND VAL-699.
Tissue: Teratocarcinoma and Tongue.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9), VARIANTS GLN-360 AND ARG-738.
Tissue: Salivary gland.
[5]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7), VARIANTS ASP-11; ASN-205 AND VAL-699.
Tissue: B-cell and Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U73682 mRNA. Translation: AAB86589.1. Different initiation.
U94780 mRNA. Translation: AAB86593.1.
AF338233 mRNA. Translation: AAN77610.1.
AF338234 mRNA. Translation: AAN77611.1.
AK091252 mRNA. Translation: BAG52318.1.
AK298935 mRNA. Translation: BAG61038.1.
BX640994 mRNA. Translation: CAE45997.1.
AL132639 Genomic DNA. No translation available.
AL157791 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65808.1.
CH471078 Genomic DNA. Translation: EAW65812.1.
CH471078 Genomic DNA. Translation: EAW65813.1.
CH471078 Genomic DNA. Translation: EAW65814.1.
BC051363 mRNA. Translation: AAH51363.2.
BC064355 mRNA. Translation: AAH64355.1.
CCDSCCDS58316.1. [O15320-5]
CCDS58317.1. [O15320-6]
CCDS9673.1. [O15320-10]
CCDS9674.1. [O15320-1]
CCDS9675.1. [O15320-2]
CCDS9676.1. [O15320-3]
RefSeqNP_001234917.1. NM_001247988.1. [O15320-7]
NP_001234918.1. NM_001247989.1. [O15320-5]
NP_001234919.1. NM_001247990.1. [O15320-6]
NP_005921.2. NM_005930.3. [O15320-1]
NP_976229.1. NM_203354.2. [O15320-10]
NP_976231.1. NM_203356.2. [O15320-3]
XP_006720211.1. XM_006720148.1. [O15320-3]
UniGeneHs.509200.
Hs.540038.
Hs.741763.

3D structure databases

ProteinModelPortalO15320.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110409. 4 interactions.
IntActO15320. 5 interactions.
MINTMINT-4526262.

PTM databases

PhosphoSiteO15320.

Proteomic databases

MaxQBO15320.
PaxDbO15320.
PRIDEO15320.

Protocols and materials databases

DNASU4253.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000280083; ENSP00000280083; ENSG00000150527. [O15320-1]
ENST00000341502; ENSP00000339286; ENSG00000150527. [O15320-4]
ENST00000341749; ENSP00000343897; ENSG00000150527. [O15320-10]
ENST00000348007; ENSP00000343912; ENSG00000150527. [O15320-2]
ENST00000396158; ENSP00000379462; ENSG00000150527. [O15320-5]
ENST00000396165; ENSP00000379468; ENSG00000150527. [O15320-3]
ENST00000553352; ENSP00000450449; ENSG00000150527. [O15320-3]
ENST00000556148; ENSP00000452562; ENSG00000150527. [O15320-6]
ENST00000557038; ENSP00000450869; ENSG00000150527. [O15320-8]
GeneID4253.
KEGGhsa:4253.
UCSCuc001wuy.4. human. [O15320-1]
uc001wuz.4. human.
uc001wvb.4. human. [O15320-7]
uc001wvf.4. human. [O15320-6]
uc001wvh.4. human. [O15320-2]
uc001wvi.4. human. [O15320-5]

Organism-specific databases

CTD4253.
GeneCardsGC14P039734.
H-InvDBHIX0021193.
HGNCHGNC:7057. CTAGE5.
HPAHPA000387.
HPA000922.
MIM602132. gene.
neXtProtNX_O15320.
PharmGKBPA30788.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG133684.
HOVERGENHBG051216.
InParanoidO15320.
OrthoDBEOG74TWXQ.
PhylomeDBO15320.
TreeFamTF333137.

Gene expression databases

BgeeO15320.
CleanExHS_CTAGE5.
GenevestigatorO15320.

Family and domain databases

ProtoNetSearch...

Other

GeneWikiCTAGE5.
GenomeRNAi4253.
NextBio16763.
PROO15320.
SOURCESearch...

Entry information

Entry nameCTGE5_HUMAN
AccessionPrimary (citable) accession number: O15320
Secondary accession number(s): B3KRA6 expand/collapse secondary AC list , B4DQS6, D3DSA6, G3XAC5, O00169, Q6MZN2, Q6P2R8, Q86TF6, Q8IX92, Q8IX93
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 121 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM