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Protein

cTAGE family member 5

Gene

CTAGE5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites.3 Publications

GO - Molecular functioni

  • enzyme activator activity Source: ProtInc

GO - Biological processi

  • cargo loading into vesicle Source: UniProtKB
  • ER to Golgi vesicle-mediated transport Source: UniProtKB
  • protein exit from endoplasmic reticulum Source: UniProtKB
  • protein localization to endoplasmic reticulum exit site Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150527-MONOMER.
ReactomeiR-HSA-5694530. Cargo concentration in the ER.

Names & Taxonomyi

Protein namesi
Recommended name:
cTAGE family member 5Imported
Short name:
Protein cTAGE-5Curated
Alternative name(s):
Meningioma-expressed antigen 6/11
Gene namesi
Name:CTAGE5Imported
Synonyms:MEA11, MEA6, MGEA11, MGEA6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:7057. CTAGE5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38LumenalCuratedAdd BLAST38
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 804CytoplasmicCuratedAdd BLAST745

GO - Cellular componenti

  • endoplasmic reticulum exit site Source: UniProtKB
  • endoplasmic reticulum membrane Source: Reactome
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Autoantibodies against CTAGE5 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi71Y → A: No effect on interaction with PERB. 1 Publication1
Mutagenesisi89K → A: Loss of interaction with PERB. Unable to recruit PERB to the endoplasmic reticulum exit sites. Loss of function in collagen VII transport. No effect on interaction with MIA3. 1 Publication1
Mutagenesisi97S → A: Decreased interaction with PERB. No effect on interaction with MIA3. 1 Publication1
Mutagenesisi112L → A: No effect on interaction with PERB. 1 Publication1

Organism-specific databases

DisGeNETi4253.
OpenTargetsiENSG00000150527.
PharmGKBiPA30788.

Polymorphism and mutation databases

BioMutaiCTAGE5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895411 – 804cTAGE family member 5Add BLAST804

Proteomic databases

EPDiO15320.
MaxQBiO15320.
PaxDbiO15320.
PeptideAtlasiO15320.
PRIDEiO15320.

PTM databases

iPTMnetiO15320.
PhosphoSitePlusiO15320.

Expressioni

Tissue specificityi

Isoform 5A is expressed only in testis (at the protein level). Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 5B, but not isoform 5A, is expressed in head and neck squamous cell carcinoma.

Gene expression databases

BgeeiENSG00000150527.
CleanExiHS_CTAGE5.
ExpressionAtlasiO15320. baseline and differential.
GenevisibleiO15320. HS.

Organism-specific databases

HPAiHPA000387.
HPA000922.

Interactioni

Subunit structurei

Interacts with MIA3 (PubMed:21525241, PubMed:25202031, PubMed:27170179). Interacts with PREB; recruits PREB to endoplasmic reticulum exit sites (PubMed:25202031, PubMed:27170179). May interact with APOB (PubMed:27138255). May interact with COPII coat subunits SEC23A and SEC24C (PubMed:21525241).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-1050253,EBI-717810
CCHCR1Q8TD31-33EBI-1050253,EBI-10175300
CEP57Q86XR83EBI-1050253,EBI-308614
EMILIN1Q9Y6C23EBI-1050253,EBI-744586
MAGEB18Q96M613EBI-1050253,EBI-741835
PSMA3P257883EBI-1050253,EBI-348380
RASAL2Q9UJF23EBI-1050253,EBI-359444
SS18L1O751773EBI-1050253,EBI-744674
TTC23LQ6PF05-33EBI-1050253,EBI-10182647

Protein-protein interaction databases

BioGridi110409. 51 interactors.
IntActiO15320. 14 interactors.
MINTiMINT-4526262.
STRINGi9606.ENSP00000280083.

Structurei

3D structure databases

ProteinModelPortaliO15320.
SMRiO15320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 650Mediates interaction with MIA31 PublicationAdd BLAST590
Regioni651 – 804Proline-rich domain (PRD); probably mediates interaction with COPII coat subunits1 PublicationAdd BLAST154

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili117 – 242Sequence analysisAdd BLAST126
Coiled coili340 – 494Sequence analysisAdd BLAST155

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi689 – 800Pro-richPROSITE-ProRule annotationAdd BLAST112

Domaini

The proline-rich domain (PRD) probably mediates interaction with the COPII coat subunits.1 Publication
The coiled coil domains mediate interaction with MIA3 (PubMed:21525241). The first coiled coil domain mediates interaction with PREB (PubMed:25202031).2 Publications

Sequence similaritiesi

Belongs to the cTAGE family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJV2. Eukaryota.
ENOG410ZUJU. LUCA.
GeneTreeiENSGT00530000063635.
HOGENOMiHOG000112043.
HOVERGENiHBG051216.
InParanoidiO15320.
OrthoDBiEOG091G0PEA.
PhylomeDBiO15320.
TreeFamiTF333137.

Sequences (10)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform MEA6 (identifier: O15320-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEPGVTPQP YLGLLLEELR RVVAALPEGM RPDSNLYGFP WELVICAAVV
60 70 80 90 100
GFFAVLFFLW RSFRSVRSRL YVGREKKLAL MLSGLIEEKS KLLEKFSLVQ
110 120 130 140 150
KEYEGYEVES SLKDASFEKE ATEAQSLEAT CEKLNRSNSE LEDEILCLEK
160 170 180 190 200
ELKEEKSKHS EQDELMADIS KRIQSLEDES KSLKSQVAEA KMTFKIFQMN
210 220 230 240 250
EERLKIAIKD ALNENSQLQE SQKQLLQEAE VWKEQVSELN KQKVTFEDSK
260 270 280 290 300
VHAEQVLNDK ESHIKTLTER LLKMKDWAAM LGEDITDDDN LELEMNSESE
310 320 330 340 350
NGAYLDNPPK GALKKLIHAA KLNASLKTLE GERNQIYIQL SEVDKTKEEL
360 370 380 390 400
TEHIKNLQTE QASLQSENTH FENENQKLQQ KLKVMTELYQ ENEMKLHRKL
410 420 430 440 450
TVEENYRLEK EEKLSKVDEK ISHATEELET YRKRAKDLEE ELERTIHSYQ
460 470 480 490 500
GQIISHEKKA HDNWLAARNA ERNLNDLRKE NAHNRQKLTE TELKFELLEK
510 520 530 540 550
DPYALDVPNT AFGREHSPYG PSPLGWPSSE TRAFLSPPTL LEGPLRLSPL
560 570 580 590 600
LPGGGGRGSR GPGNPLDHQI TNERGESSCD RLTDPHRAPS DTGSLSPPWD
610 620 630 640 650
QDRRMMFPPP GQSYPDSALP PQRQDRFCSN SGRLSGPAEL RSFNMPSLDK
660 670 680 690 700
MDGSMPSEME SSRNDTKDDL GNLNVPDSSL PAENEATGPG FVPPPLAPIR
710 720 730 740 750
GPLFPVDARG PFLRRGPPFP PPPPGAMFGA SRDYFPPGDF PGPPPAPFAM
760 770 780 790 800
RNVYPPRGFP PYLPPRPGFF PPPPHSEGRS EFPSGLIPPS NEPATEHPEP

QQET
Length:804
Mass (Da):90,996
Last modified:November 2, 2010 - v4
Checksum:iEB2CAC59C4ED7867
GO
Isoform MEA11 (identifier: O15320-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     514-556: Missing.

Note: No experimental confirmation available.
Show »
Length:761
Mass (Da):86,532
Checksum:iB101FD49659A2F30
GO
Isoform 5A (identifier: O15320-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:775
Mass (Da):87,837
Checksum:i46C11CD859A408FF
GO
Isoform 5B (identifier: O15320-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-771: MRNVYPPRGFPPYLPPRPGFFP → SARSPPGAGAPASGRGLGGPQK
     772-804: Missing.

Show »
Length:771
Mass (Da):86,811
Checksum:i2E5D4546606E6EC3
GO
Isoform 6 (identifier: O15320-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-128: E → EVENQM

Show »
Length:809
Mass (Da):91,598
Checksum:i93E6E1B2E908306B
GO
Isoform 7 (identifier: O15320-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     128-128: E → EVENQM

Show »
Length:729
Mass (Da):82,443
Checksum:i31620F247C9CF9A1
GO
Isoform 8 (identifier: O15320-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     515-557: Missing.

Show »
Length:732
Mass (Da):83,373
Checksum:i3A7C4AC2B3D65396
GO
Isoform 9 (identifier: O15320-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Show »
Length:724
Mass (Da):81,841
Checksum:iAFE56681C351F234
GO
Isoform 10 (identifier: O15320-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-21: EPGVTPQPYLGLLLEELRR → LKSPEEE
     103-128: Missing.
     647-717: Missing.
     725-747: Missing.

Show »
Length:672
Mass (Da):76,880
Checksum:iCA742CB43201E4FE
GO
Isoform 11 (identifier: O15320-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-21: EPGVTPQPYLGLLLEELRR → LKSPEEE

Note: Gene prediction based on EST data.
Show »
Length:792
Mass (Da):89,647
Checksum:i0C9C6951D420A590
GO

Sequence cautioni

The sequence AAB86589 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90S → N in CAE45997 (PubMed:17974005).Curated1
Sequence conflicti145I → M in CAE45997 (PubMed:17974005).Curated1
Sequence conflicti195K → Q in AAB86593 (PubMed:9356211).Curated1
Sequence conflicti195K → Q in AAB86589 (PubMed:9356211).Curated1
Sequence conflicti198Q → P in AAB86593 (PubMed:9356211).Curated1
Sequence conflicti546R → T in AAB86593 (PubMed:9356211).Curated1
Sequence conflicti589P → L in AAB86593 (PubMed:9356211).Curated1
Sequence conflicti594S → F in AAB86593 (PubMed:9356211).Curated1
Sequence conflicti604R → M in AAN77610 (PubMed:12839582).Curated1
Sequence conflicti776S → F in AAN77610 (PubMed:12839582).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0478896V → A.2 PublicationsCorresponds to variant rs7140561dbSNPEnsembl.1
Natural variantiVAR_04789011Y → D.1 PublicationCorresponds to variant rs17855895dbSNPEnsembl.1
Natural variantiVAR_047891205K → N.1 PublicationCorresponds to variant rs17855896dbSNPEnsembl.1
Natural variantiVAR_047892250K → E.Corresponds to variant rs10162564dbSNPEnsembl.1
Natural variantiVAR_047893360E → Q.4 PublicationsCorresponds to variant rs1950952dbSNPEnsembl.1
Natural variantiVAR_047894375N → S.Corresponds to variant rs17109109dbSNPEnsembl.1
Natural variantiVAR_047895699I → V.3 PublicationsCorresponds to variant rs1140952dbSNPEnsembl.1
Natural variantiVAR_047896738G → R.3 PublicationsCorresponds to variant rs1060878dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0359611 – 80Missing in isoform 7 and isoform 9. 2 PublicationsAdd BLAST80
Alternative sequenceiVSP_0125451 – 29Missing in isoform 5A and isoform 8. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_0472343 – 21EPGVT…EELRR → LKSPEEE in isoform 10 and isoform 11. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_047235103 – 128Missing in isoform 10. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_035962128E → EVENQM in isoform 6 and isoform 7. 1 Publication1
Alternative sequenceiVSP_004322514 – 556Missing in isoform MEA11. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_035963515 – 557Missing in isoform 8. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_047236647 – 717Missing in isoform 10. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_047237725 – 747Missing in isoform 10. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_012546750 – 771MRNVY…PGFFP → SARSPPGAGAPASGRGLGGP QK in isoform 5B. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_012547772 – 804Missing in isoform 5B. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73682 mRNA. Translation: AAB86589.1. Different initiation.
U94780 mRNA. Translation: AAB86593.1.
AF338233 mRNA. Translation: AAN77610.1.
AF338234 mRNA. Translation: AAN77611.1.
AK091252 mRNA. Translation: BAG52318.1.
AK298935 mRNA. Translation: BAG61038.1.
BX640994 mRNA. Translation: CAE45997.1.
AL132639 Genomic DNA. No translation available.
AL157791 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65808.1.
CH471078 Genomic DNA. Translation: EAW65812.1.
CH471078 Genomic DNA. Translation: EAW65813.1.
CH471078 Genomic DNA. Translation: EAW65814.1.
BC051363 mRNA. Translation: AAH51363.2.
BC064355 mRNA. Translation: AAH64355.1.
CCDSiCCDS58316.1. [O15320-5]
CCDS58317.1. [O15320-6]
CCDS9673.1. [O15320-10]
CCDS9674.1. [O15320-1]
CCDS9675.1. [O15320-2]
CCDS9676.1. [O15320-3]
RefSeqiNP_001234917.1. NM_001247988.1. [O15320-7]
NP_001234918.1. NM_001247989.1. [O15320-5]
NP_001234919.1. NM_001247990.1. [O15320-6]
NP_005921.2. NM_005930.3. [O15320-1]
NP_976229.1. NM_203354.2. [O15320-10]
NP_976231.1. NM_203356.2. [O15320-3]
XP_006720211.1. XM_006720148.2. [O15320-3]
XP_011535086.1. XM_011536784.2. [O15320-8]
XP_011535087.1. XM_011536785.2. [O15320-8]
XP_016876809.1. XM_017021320.1. [O15320-3]
XP_016876814.1. XM_017021325.1. [O15320-7]
UniGeneiHs.287694.
Hs.509200.
Hs.540038.
Hs.741763.

Genome annotation databases

EnsembliENST00000280083; ENSP00000280083; ENSG00000150527. [O15320-1]
ENST00000341502; ENSP00000339286; ENSG00000150527. [O15320-4]
ENST00000341749; ENSP00000343897; ENSG00000150527. [O15320-10]
ENST00000348007; ENSP00000343912; ENSG00000150527. [O15320-2]
ENST00000396158; ENSP00000379462; ENSG00000150527. [O15320-5]
ENST00000396165; ENSP00000379468; ENSG00000150527. [O15320-3]
ENST00000553352; ENSP00000450449; ENSG00000150527. [O15320-3]
ENST00000556148; ENSP00000452562; ENSG00000150527. [O15320-6]
ENST00000557038; ENSP00000450869; ENSG00000150527. [O15320-8]
GeneIDi4253.
KEGGihsa:4253.
UCSCiuc001wuy.5. human. [O15320-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73682 mRNA. Translation: AAB86589.1. Different initiation.
U94780 mRNA. Translation: AAB86593.1.
AF338233 mRNA. Translation: AAN77610.1.
AF338234 mRNA. Translation: AAN77611.1.
AK091252 mRNA. Translation: BAG52318.1.
AK298935 mRNA. Translation: BAG61038.1.
BX640994 mRNA. Translation: CAE45997.1.
AL132639 Genomic DNA. No translation available.
AL157791 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65808.1.
CH471078 Genomic DNA. Translation: EAW65812.1.
CH471078 Genomic DNA. Translation: EAW65813.1.
CH471078 Genomic DNA. Translation: EAW65814.1.
BC051363 mRNA. Translation: AAH51363.2.
BC064355 mRNA. Translation: AAH64355.1.
CCDSiCCDS58316.1. [O15320-5]
CCDS58317.1. [O15320-6]
CCDS9673.1. [O15320-10]
CCDS9674.1. [O15320-1]
CCDS9675.1. [O15320-2]
CCDS9676.1. [O15320-3]
RefSeqiNP_001234917.1. NM_001247988.1. [O15320-7]
NP_001234918.1. NM_001247989.1. [O15320-5]
NP_001234919.1. NM_001247990.1. [O15320-6]
NP_005921.2. NM_005930.3. [O15320-1]
NP_976229.1. NM_203354.2. [O15320-10]
NP_976231.1. NM_203356.2. [O15320-3]
XP_006720211.1. XM_006720148.2. [O15320-3]
XP_011535086.1. XM_011536784.2. [O15320-8]
XP_011535087.1. XM_011536785.2. [O15320-8]
XP_016876809.1. XM_017021320.1. [O15320-3]
XP_016876814.1. XM_017021325.1. [O15320-7]
UniGeneiHs.287694.
Hs.509200.
Hs.540038.
Hs.741763.

3D structure databases

ProteinModelPortaliO15320.
SMRiO15320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110409. 51 interactors.
IntActiO15320. 14 interactors.
MINTiMINT-4526262.
STRINGi9606.ENSP00000280083.

PTM databases

iPTMnetiO15320.
PhosphoSitePlusiO15320.

Polymorphism and mutation databases

BioMutaiCTAGE5.

Proteomic databases

EPDiO15320.
MaxQBiO15320.
PaxDbiO15320.
PeptideAtlasiO15320.
PRIDEiO15320.

Protocols and materials databases

DNASUi4253.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280083; ENSP00000280083; ENSG00000150527. [O15320-1]
ENST00000341502; ENSP00000339286; ENSG00000150527. [O15320-4]
ENST00000341749; ENSP00000343897; ENSG00000150527. [O15320-10]
ENST00000348007; ENSP00000343912; ENSG00000150527. [O15320-2]
ENST00000396158; ENSP00000379462; ENSG00000150527. [O15320-5]
ENST00000396165; ENSP00000379468; ENSG00000150527. [O15320-3]
ENST00000553352; ENSP00000450449; ENSG00000150527. [O15320-3]
ENST00000556148; ENSP00000452562; ENSG00000150527. [O15320-6]
ENST00000557038; ENSP00000450869; ENSG00000150527. [O15320-8]
GeneIDi4253.
KEGGihsa:4253.
UCSCiuc001wuy.5. human. [O15320-1]

Organism-specific databases

CTDi4253.
DisGeNETi4253.
GeneCardsiCTAGE5.
H-InvDBHIX0021193.
HGNCiHGNC:7057. CTAGE5.
HPAiHPA000387.
HPA000922.
MIMi602132. gene.
neXtProtiNX_O15320.
OpenTargetsiENSG00000150527.
PharmGKBiPA30788.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJV2. Eukaryota.
ENOG410ZUJU. LUCA.
GeneTreeiENSGT00530000063635.
HOGENOMiHOG000112043.
HOVERGENiHBG051216.
InParanoidiO15320.
OrthoDBiEOG091G0PEA.
PhylomeDBiO15320.
TreeFamiTF333137.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150527-MONOMER.
ReactomeiR-HSA-5694530. Cargo concentration in the ER.

Miscellaneous databases

GeneWikiiCTAGE5.
GenomeRNAii4253.
PROiO15320.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150527.
CleanExiHS_CTAGE5.
ExpressionAtlasiO15320. baseline and differential.
GenevisibleiO15320. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCTGE5_HUMAN
AccessioniPrimary (citable) accession number: O15320
Secondary accession number(s): B3KRA6
, B4DQS6, D3DSA6, G3XAC5, O00169, Q6MZN2, Q6P2R8, Q86TF6, Q8IX92, Q8IX93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 145 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is unclear whether MIA2 and CTAGE5 constitute 2 distinct genes or a single one similar to MIA3.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.