Reviewed, UniProtKB/Swiss-Prot O15263 (DEFB2_HUMAN)

Names and origin

Protein names

Recommended name:
    Beta-defensin 2
      Short name=BD-2
      Short name=hBD-2
Alternative name(s):
    Defensin, beta 2
    Skin-antimicrobial peptide 1
      Short name=SAP1

Gene names

Name:	DEFB4
Synonyms:	DEFB102, DEFB2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	64 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Has antibacterial activity Potential.
Subcellular location	Secreted.
Tissue specificity	Expressed in the skin and respiratory tract.
Induction	By inflammation.
Sequence similarities	Belongs to the beta-defensin family. LAP/TAP subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	3D-structure
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Traceable author statement. Source: ProtInc chemotaxis Traceable author statement. Source: ProtInc defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW immune response Traceable author statement. Source: ProtInc
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

23

Potential

Peptide

24 – 64

41

Beta-defensin 2

PRO_0000006968

Amino acid modifications

Disulfide bond

31 ↔ 60

Disulfide bond

38 ↔ 53

Disulfide bond

43 ↔ 61

Secondary structure

1

.

.

.

.

.

.

.

.

.

64

Helix Strand Turn

Details...

Helix

28 – 33

6

Beta strand

37 – 41

5

Beta strand

48 – 52

5

Beta strand

59 – 62

4

Sequences

	Sequence		Length	Mass (Da)
	O15263-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 05D6454CE7ACD10E	FASTA	64	7,038
	10 20 30 40 50 60 MRVLYLLFSF LFIFLMPLPG VFGGIGDPVT CLKSGAICHP VFCPRRYKQI GTCGLPGTKC CKKP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A peptide antibiotic from human skin." Harder J., Bartels J.H., Christophers E., Schroeder J.-M. Nature 387:861-861(1997) [PubMed: 9202117] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skin.
[2]	"Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation." Liu L., Wang L., Jia H.P., Zhao C., Heng H.H.Q., Schutte B.C., McCray P.B. Jr., Ganz T. Gene 222:237-244(1998) [PubMed: 9831658] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[3]	"Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells." Diamond G., Kaiser V., Rhodes J., Russell J.P., Bevins C.L. Infect. Immun. 68:113-119(2000) [PubMed: 10603376] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia." Harder J., Meyer-Hoffert U., Teran L.M., Schwichtenberg L., Bartels J., Maune S., Schroeder J.-M. Am. J. Respir. Cell Mol. Biol. 22:714-721(2000) [PubMed: 10837369] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"Chemical synthesis of beta-defensins and LEAP-1/hepcidin." Kluever E., Schulz A., Forssmann W.-G., Adermann K. J. Pept. Res. 59:241-248(2002) [PubMed: 12010514] [Abstract] Cited for: SYNTHESIS OF 24-64.
[7]	"The structure of human beta-defensin-2 shows evidence of higher order oligomerization." Hoover D.M., Rajashankar K.R., Blumenthal R., Puri A., Oppenheim J.J., Chertov O., Lubkowski J. J. Biol. Chem. 275:32911-32918(2000) [PubMed: 10906336] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS).
[8]	"Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity." Bauer F., Schweimer K., Kluever E., Conejo-Garcia J.-R., Forssmann W.-G., Roesch P., Adermann K., Sticht H. Protein Sci. 10:2470-2479(2001) [PubMed: 11714914] [Abstract] Cited for: STRUCTURE BY NMR OF 28-64.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

Z71389 mRNA. Translation: CAA95992.1.
AF040153 Genomic DNA. Translation: AAC33549.1.
AF071216 Genomic DNA. Translation: AAC69554.1.
AJ000152 Genomic DNA. Translation: CAB65126.1.
BC069285 mRNA. Translation: AAH69285.1.
BC093983 mRNA. Translation: AAH93983.1.
BC093985 mRNA. Translation: AAH93985.1.

IPI

IPI00005739.

RefSeq

NP_004933.1.

UniGene

Hs.105924

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1E4Q	NMR	-	A	28-64	[»]
1FD3	X-ray	1.35	A/B/C/D	24-64	[»]
1FD4	X-ray	1.70	A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P	24-64	[»]
1FQQ	NMR	-	A	24-64	[»]

ModBase

Search...

Protein family/group databases

TCDB

1.C.85.1.2. pore-forming &#946,-defensin (&#946,-Defensin) family.

Genome annotation databases

Ensembl

ENSG00000171711. Homo sapiens. [Contig view]
ENSG00000177257. Homo sapiens. [Contig view]

GeneID

1673.

KEGG

hsa:1673.

Organism-specific databases

GeneCards

GC08P007789.

H-InvDB

HIX0034349.
HIX0034666.

HGNC

HGNC:2767. DEFB4.

MIM

602215. gene.

PharmGKB

PA27249.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

O15263.

HOVERGEN

O15263.

OMA

O15263. SGAICHP.

Gene expression databases

CleanEx

HS_DEFB4.

GermOnline

ENSG00000171711. Homo sapiens.
ENSG00000177257. Homo sapiens.

Family and domain databases

InterPro

IPR001855. Defensin_beta.
IPR006080. Defensin_mammal.
[Graphical view]

Pfam

PF00711. Defensin_beta. 1 hit.
[Graphical view]

SMART

SM00048. DEFSN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

6884.

SOURCE

Search...

Entry information

Entry name

DEFB2_HUMAN

Accession

Primary (citable) accession number: O15263
Secondary accession number(s): Q52LC0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)