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Protein

Beta-defensin 4A

Gene

DEFB4A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036).1 Publication

GO - Molecular functioni

  • CCR6 chemokine receptor binding Source: UniProtKB

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • antimicrobial humoral response Source: Reactome
  • chemotaxis Source: UniProtKB
  • defense response to bacterium Source: MGI
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • immune response Source: ProtInc
  • killing of cells of other organism Source: UniProtKB

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Protein family/group databases

TCDBi1.C.85.1.2 the pore-forming -defensin (-defensin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 4A
Alternative name(s):
Beta-defensin 2
Short name:
BD-2
Short name:
hBD-2
Defensin, beta 2
Skin-antimicrobial peptide 1
Short name:
SAP1
Gene namesi
Name:DEFB4A
Synonyms:DEFB102, DEFB2, DEFB4
AND
Name:DEFB4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000171711.2
HostDB:ENSG00000177257.2
HGNCiHGNC:2767 DEFB4A
HGNC:30193 DEFB4B
MIMi602215 gene
neXtProtiNX_O15263

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi100289462
1673
OpenTargetsiENSG00000171711
ENSG00000177257
PharmGKBiPA27249

Polymorphism and mutation databases

BioMutaiDEFB4A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PeptideiPRO_000000696824 – 64Beta-defensin 4AAdd BLAST41

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 60
Disulfide bondi38 ↔ 53
Disulfide bondi43 ↔ 61

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO15263
PeptideAtlasiO15263
PRIDEiO15263
ProteomicsDBi48551

Expressioni

Tissue specificityi

Expressed in the skin and respiratory tract.

Inductioni

By inflammation.

Gene expression databases

BgeeiENSG00000171711
CleanExiHS_DEFB4
GenevisibleiO15263 HS

Interactioni

GO - Molecular functioni

  • CCR6 chemokine receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108037, 3 interactors
STRINGi9606.ENSP00000424598

Chemistry databases

BindingDBiO15263

Structurei

Secondary structure

164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 27Combined sources3
Helixi28 – 33Combined sources6
Beta strandi37 – 41Combined sources5
Beta strandi48 – 52Combined sources5
Beta strandi53 – 55Combined sources3
Beta strandi59 – 62Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E4QNMR-A28-64[»]
1FD3X-ray1.35A/B/C/D24-64[»]
1FD4X-ray1.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P24-64[»]
1FQQNMR-A24-64[»]
ProteinModelPortaliO15263
SMRiO15263
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15263

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family. LAP/TAP subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JJAE Eukaryota
ENOG411147G LUCA
GeneTreeiENSGT00730000111909
HOGENOMiHOG000015465
HOVERGENiHBG004834
InParanoidiO15263
KOiK21100
OMAiINNPITC
OrthoDBiEOG091G1ANZ
PhylomeDBiO15263

Family and domain databases

InterProiView protein in InterPro
IPR001855 Defensin_beta-typ
IPR006080 Defensin_beta/alpha
PfamiView protein in Pfam
PF00711 Defensin_beta, 1 hit
SMARTiView protein in SMART
SM00048 DEFSN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLYLLFSF LFIFLMPLPG VFGGIGDPVT CLKSGAICHP VFCPRRYKQI
60
GTCGLPGTKC CKKP
Length:64
Mass (Da):7,038
Last modified:January 1, 1998 - v1
Checksum:i05D6454CE7ACD10E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71389 mRNA Translation: CAA95992.1
AF040153 Genomic DNA Translation: AAC33549.1
AF071216 Genomic DNA Translation: AAC69554.1
AJ000152 Genomic DNA Translation: CAB65126.1
BC069285 mRNA Translation: AAH69285.1
BC093983 mRNA Translation: AAH93983.1
BC093985 mRNA Translation: AAH93985.1
CCDSiCCDS5971.1
RefSeqiNP_001192195.1, NM_001205266.1
NP_004933.1, NM_004942.3
UniGeneiHs.105924
Hs.740237

Genome annotation databases

EnsembliENST00000302247; ENSP00000303532; ENSG00000171711
ENST00000318157; ENSP00000424598; ENSG00000177257
ENST00000617136; ENSP00000479138; ENSG00000275444
ENST00000642856; ENSP00000496499; ENSG00000285181
ENST00000644124; ENSP00000493760; ENSG00000285433
GeneIDi100289462
1673
KEGGihsa:100289462
hsa:1673
UCSCiuc003wsd.4 human

Similar proteinsi

Entry informationi

Entry nameiDFB4A_HUMAN
AccessioniPrimary (citable) accession number: O15263
Secondary accession number(s): Q52LC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: June 20, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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