Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein RER1

Gene

RER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157916-MONOMER.

Protein family/group databases

TCDBi9.B.82.1.2. endoplasmic reticulum retrieval protein1 (putative heavy metal transporter) (rer1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RER1
Gene namesi
Name:RER1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30309. RER1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11079.
OpenTargetsiENSG00000157916.
PharmGKBiPA134901074.

Polymorphism and mutation databases

BioMutaiRER1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002075892 – 196Protein RER1Add BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei95PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO15258.
PaxDbiO15258.
PeptideAtlasiO15258.
PRIDEiO15258.

PTM databases

iPTMnetiO15258.
PhosphoSitePlusiO15258.
SwissPalmiO15258.

Expressioni

Gene expression databases

BgeeiENSG00000157916.
CleanExiHS_RER1.
ExpressionAtlasiO15258. baseline and differential.
GenevisibleiO15258. HS.

Organism-specific databases

HPAiCAB037240.
HPA051400.

Interactioni

Protein-protein interaction databases

BioGridi116262. 34 interactors.
IntActiO15258. 13 interactors.
MINTiMINT-4726643.
STRINGi9606.ENSP00000302088.

Structurei

3D structure databases

ProteinModelPortaliO15258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RER1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1688. Eukaryota.
COG5249. LUCA.
GeneTreeiENSGT00510000047137.
HOVERGENiHBG002871.
InParanoidiO15258.
PhylomeDBiO15258.
TreeFamiTF300029.

Family and domain databases

InterProiIPR004932. Rer1.
[Graphical view]
PANTHERiPTHR10743. PTHR10743. 1 hit.
PfamiPF03248. Rer1. 1 hit.
[Graphical view]
PIRSFiPIRSF016013. AtER_Rer1p. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEGDSVGES VHGKPSVVYR FFTRLGQIYQ SWLDKSTPYT AVRWVVTLGL
60 70 80 90 100
SFVYMIRVYL LQGWYIVTYA LGIYHLNLFI AFLSPKVDPS LMEDSDDGPS
110 120 130 140 150
LPTKQNEEFR PFIRRLPEFK FWHAATKGIL VAMVCTFFDA FNVPVFWPIL
160 170 180 190
VMYFIMLFCI TMKRQIKHMI KYRYIPFTHG KRRYRGKEDA GKAFAS
Length:196
Mass (Da):22,958
Last modified:January 1, 1998 - v1
Checksum:i0FF7F3CDC9F88A69
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123 – 196HAATK…KAFAS → DASVCGDGRCSCKAGGGRQC PVLAADAALTFSPHLKACGY QGHPCGYGLYFLRRFQRPGV LADSGDVLHHALLYHDEEAN QAHD in AAC72940 (Ref. 2) CuratedAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001421 mRNA. Translation: CAA04754.1.
AF091071 mRNA. Translation: AAC72940.1.
BC004965 mRNA. Translation: AAH04965.1.
CCDSiCCDS41232.1.
RefSeqiNP_008964.3. NM_007033.4.
XP_006710369.1. XM_006710306.2.
XP_011538844.1. XM_011540542.1.
XP_011538845.1. XM_011540543.1.
XP_016855622.1. XM_017000133.1.
XP_016855623.1. XM_017000134.1.
XP_016855624.1. XM_017000135.1.
UniGeneiHs.525527.

Genome annotation databases

EnsembliENST00000488353; ENSP00000464222; ENSG00000157916.
ENST00000605895; ENSP00000475168; ENSG00000157916.
GeneIDi11079.
KEGGihsa:11079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001421 mRNA. Translation: CAA04754.1.
AF091071 mRNA. Translation: AAC72940.1.
BC004965 mRNA. Translation: AAH04965.1.
CCDSiCCDS41232.1.
RefSeqiNP_008964.3. NM_007033.4.
XP_006710369.1. XM_006710306.2.
XP_011538844.1. XM_011540542.1.
XP_011538845.1. XM_011540543.1.
XP_016855622.1. XM_017000133.1.
XP_016855623.1. XM_017000134.1.
XP_016855624.1. XM_017000135.1.
UniGeneiHs.525527.

3D structure databases

ProteinModelPortaliO15258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116262. 34 interactors.
IntActiO15258. 13 interactors.
MINTiMINT-4726643.
STRINGi9606.ENSP00000302088.

Protein family/group databases

TCDBi9.B.82.1.2. endoplasmic reticulum retrieval protein1 (putative heavy metal transporter) (rer1) family.

PTM databases

iPTMnetiO15258.
PhosphoSitePlusiO15258.
SwissPalmiO15258.

Polymorphism and mutation databases

BioMutaiRER1.

Proteomic databases

EPDiO15258.
PaxDbiO15258.
PeptideAtlasiO15258.
PRIDEiO15258.

Protocols and materials databases

DNASUi11079.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000488353; ENSP00000464222; ENSG00000157916.
ENST00000605895; ENSP00000475168; ENSG00000157916.
GeneIDi11079.
KEGGihsa:11079.

Organism-specific databases

CTDi11079.
DisGeNETi11079.
GeneCardsiRER1.
HGNCiHGNC:30309. RER1.
HPAiCAB037240.
HPA051400.
neXtProtiNX_O15258.
OpenTargetsiENSG00000157916.
PharmGKBiPA134901074.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1688. Eukaryota.
COG5249. LUCA.
GeneTreeiENSGT00510000047137.
HOVERGENiHBG002871.
InParanoidiO15258.
PhylomeDBiO15258.
TreeFamiTF300029.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157916-MONOMER.

Miscellaneous databases

ChiTaRSiRER1. human.
GenomeRNAii11079.
PROiO15258.

Gene expression databases

BgeeiENSG00000157916.
CleanExiHS_RER1.
ExpressionAtlasiO15258. baseline and differential.
GenevisibleiO15258. HS.

Family and domain databases

InterProiIPR004932. Rer1.
[Graphical view]
PANTHERiPTHR10743. PTHR10743. 1 hit.
PfamiPF03248. Rer1. 1 hit.
[Graphical view]
PIRSFiPIRSF016013. AtER_Rer1p. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRER1_HUMAN
AccessioniPrimary (citable) accession number: O15258
Secondary accession number(s): O95322
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.