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Protein

CAAX box protein 1

Gene

RTL8C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

There seems to be two proteins encoded by the FAM127A gene, one with a C-terminal CAAX box (the sequence shown here) and a smaller protein (AC A6ZKI3).Curated

Names & Taxonomyi

Protein namesi
Recommended name:
CAAX box protein 1
Alternative name(s):
Cerebral protein 5
Gene namesi
Name:RTL8CImported
Synonyms:CXX1, FAM127A, MAR8, MAR8C, MART8
ORF Names:hucep-5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:2569 RTL8C
MIMi300213 gene
neXtProtiNX_O15255

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000797451 – 206CAAX box protein 1Add BLAST206
PropeptideiPRO_0000396750207 – 209Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei206Cysteine methyl esterSequence analysis1
Lipidationi206S-farnesyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiO15255

PTM databases

iPTMnetiO15255

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

CleanExiHS_FAM127A

Interactioni

Protein-protein interaction databases

IntActiO15255, 2 interactors

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG001853
InParanoidiO15255
PhylomeDBiO15255

Family and domain databases

InterProiView protein in InterPro
IPR031771 CAAX_1
PfamiView protein in Pfam
PF15895 CAAX_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGRGLLGR ETLGPGGGCS GEGPLCYWPP PGSPPAPSLR ASLPLEPPRC
60 70 80 90 100
PLRSCSLPRS ACLCSRNSAP GSCCRPWASL WSEPPPSPSS QPAPPMYIWT
110 120 130 140 150
LSCAPAASWA PVTHWTDHPL PPLPSPLLPT RLPDDYIILP TDLRCHSHRH
160 170 180 190 200
PSHPTDRLLL LVIWTHLGGI WAGHSPWTVI QTAGRPPRDL SPSARPISSP

PPETSCVLA
Length:209
Mass (Da):22,278
Last modified:January 1, 1998 - v1
Checksum:i976E0D2AE93023A8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037283152S → W. Corresponds to variant dbSNP:rs5930670Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13374 mRNA Translation: CAA73804.1
D88756 mRNA Translation: BAB46920.1
AF038168 mRNA Translation: AAB97361.1
AF052096 mRNA Translation: AAC28618.1
CR456853 mRNA Translation: CAG33134.1
AL136169 Genomic DNA No translation available.
BC002385 mRNA No translation available.
BC002410 mRNA No translation available.
UniGeneiHs.522789

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCXX1_HUMAN
AccessioniPrimary (citable) accession number: O15255
Secondary accession number(s): Q6IBF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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