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Protein

CAAX box protein 1

Gene

FAM127A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
CAAX box protein 1
Alternative name(s):
Cerebral protein 5
Gene namesi
Name:FAM127A
Synonyms:CXX1, MAR8, MAR8C, MART8
ORF Names:hucep-5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:2569. FAM127A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206CAAX box protein 1PRO_0000079745Add
BLAST
Propeptidei207 – 2093Removed in mature formSequence analysisPRO_0000396750

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei206 – 2061Cysteine methyl esterSequence analysis
Lipidationi206 – 2061S-farnesyl cysteineSequence analysis

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiO15255.

PTM databases

iPTMnetiO15255.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

CleanExiHS_FAM127A.

Interactioni

Protein-protein interaction databases

IntActiO15255. 2 interactions.
MINTiMINT-2865579.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG001853.
InParanoidiO15255.
PhylomeDBiO15255.

Family and domain databases

InterProiIPR031771. CAAX_1.
[Graphical view]
PfamiPF15895. CAAX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGRGLLGR ETLGPGGGCS GEGPLCYWPP PGSPPAPSLR ASLPLEPPRC
60 70 80 90 100
PLRSCSLPRS ACLCSRNSAP GSCCRPWASL WSEPPPSPSS QPAPPMYIWT
110 120 130 140 150
LSCAPAASWA PVTHWTDHPL PPLPSPLLPT RLPDDYIILP TDLRCHSHRH
160 170 180 190 200
PSHPTDRLLL LVIWTHLGGI WAGHSPWTVI QTAGRPPRDL SPSARPISSP

PPETSCVLA
Length:209
Mass (Da):22,278
Last modified:January 1, 1998 - v1
Checksum:i976E0D2AE93023A8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti152 – 1521S → W.
Corresponds to variant rs5930670 [ dbSNP | Ensembl ].
VAR_037283

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13374 mRNA. Translation: CAA73804.1.
D88756 mRNA. Translation: BAB46920.1.
AF038168 mRNA. Translation: AAB97361.1.
AF052096 mRNA. Translation: AAC28618.1.
CR456853 mRNA. Translation: CAG33134.1.
AL136169 Genomic DNA. No translation available.
BC002385 mRNA. No translation available.
BC002410 mRNA. No translation available.
UniGeneiHs.522789.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13374 mRNA. Translation: CAA73804.1.
D88756 mRNA. Translation: BAB46920.1.
AF038168 mRNA. Translation: AAB97361.1.
AF052096 mRNA. Translation: AAC28618.1.
CR456853 mRNA. Translation: CAG33134.1.
AL136169 Genomic DNA. No translation available.
BC002385 mRNA. No translation available.
BC002410 mRNA. No translation available.
UniGeneiHs.522789.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO15255. 2 interactions.
MINTiMINT-2865579.

PTM databases

iPTMnetiO15255.

Proteomic databases

PRIDEiO15255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiFAM127A.
H-InvDBHIX0017070.
HGNCiHGNC:2569. FAM127A.
MIMi300213. gene.
neXtProtiNX_O15255.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG001853.
InParanoidiO15255.
PhylomeDBiO15255.

Miscellaneous databases

ChiTaRSiFAM127A. human.
SOURCEiSearch...

Gene expression databases

CleanExiHS_FAM127A.

Family and domain databases

InterProiIPR031771. CAAX_1.
[Graphical view]
PfamiPF15895. CAAX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXX1_HUMAN
AccessioniPrimary (citable) accession number: O15255
Secondary accession number(s): Q6IBF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

There seems to be two proteins encoded by the FAM127A gene, one with a C-terminal CAAX box (the sequence shown here) and a smaller protein (AC A6ZKI3).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.