ID ACOX3_HUMAN Reviewed; 700 AA. AC O15254; Q96AJ8; DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot. DT 20-FEB-2007, sequence version 2. DT 16-JUN-2009, entry version 77. DE RecName: Full=Peroxisomal acyl-coenzyme A oxidase 3; DE EC=1.3.3.6; DE AltName: Full=Pristanoyl-CoA oxidase; DE AltName: Full=Branched-chain acyl-CoA oxidase; DE Short=BRCACox; GN Name=ACOX3; Synonyms=BRCOX, PRCOX; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND FUNCTION. RC TISSUE=Liver; RX MEDLINE=97373507; PubMed=9271077; RA Vanhooren J.C.T., Marynen P., Mannaerts G.P., van Veldhoven P.P.; RT "Evidence for the existence of a pristanoyl-CoA oxidase gene in man."; RL Biochem. J. 325:593-599(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Uterus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Oxidizes the CoA-esters of 2-methyl-branched fatty acids CC (By similarity). CC -!- CATALYTIC ACTIVITY: Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + CC H(2)O(2). CC -!- COFACTOR: FAD (By similarity). CC -!- PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation. CC -!- SUBCELLULAR LOCATION: Peroxisome (Potential). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=O15254-1; Sequence=Displayed; CC Name=2; CC IsoId=O15254-2; Sequence=VSP_023355, VSP_023356; CC Note=No experimental confirmation available; CC -!- SIMILARITY: Belongs to the acyl-CoA oxidase family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; Y11411; CAA72214.1; -; mRNA. DR EMBL; BC017053; AAH17053.1; -; mRNA. DR IPI; IPI00020226; -. DR IPI; IPI00827610; -. DR RefSeq; NP_001095137.1; -. DR RefSeq; NP_003492.2; -. DR UniGene; Hs.479122; -. DR HSSP; P07872; 1IS2. DR PRIDE; O15254; -. DR Ensembl; ENSG00000087008; Homo sapiens. DR GeneID; 8310; -. DR KEGG; hsa:8310; -. DR GeneCards; GC04M008486; -. DR H-InvDB; HIX0004086; -. DR HGNC; HGNC:121; ACOX3. DR MIM; 603402; gene. DR PharmGKB; PA24445; -. DR HOGENOM; O15254; -. DR HOVERGEN; O15254; -. DR OMA; O15254; ALYGLWS. DR BRENDA; 1.3.3.6; 247. DR NextBio; 31121; -. DR ArrayExpress; O15254; -. DR Bgee; O15254; -. DR CleanEx; HS_ACOX3; -. DR GermOnline; ENSG00000087008; Homo sapiens. DR GO; GO:0005777; C:peroxisome; TAS:ProtInc. DR GO; GO:0003995; F:acyl-CoA dehydrogenase activity; IEA:InterPro. DR GO; GO:0003997; F:acyl-CoA oxidase activity; TAS:ProtInc. DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro. DR GO; GO:0050660; F:FAD binding; IEA:InterPro. DR GO; GO:0008206; P:bile acid metabolic process; TAS:ProtInc. DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:InterPro. DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW. DR InterPro; IPR006090; Acyl-CoA_Oxase/DH_1. DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_M. DR InterPro; IPR012258; Acyl-CoA_oxidase. DR InterPro; IPR002655; Acyl-CoA_oxidase_C. DR InterPro; IPR013786; AcylCoA_DH/ox_N. DR InterPro; IPR013764; AcylCoA_oxidase/DH_1/2_C. DR Gene3D; G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1. DR Gene3D; G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1. DR Gene3D; G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 2. DR PANTHER; PTHR10909:SF11; Acyl-CoA_oxidase; 1. DR Pfam; PF01756; ACOX; 1. DR Pfam; PF00441; Acyl-CoA_dh_1; 1. DR Pfam; PF02770; Acyl-CoA_dh_M; 1. DR PIRSF; PIRSF000168; Acyl-CoA_oxidase; 1. PE 2: Evidence at transcript level; KW Alternative splicing; FAD; Fatty acid metabolism; Flavoprotein; KW Lipid metabolism; Oxidoreductase; Peroxisome; Polymorphism. FT CHAIN 1 700 Peroxisomal acyl-coenzyme A oxidase 3. FT /FTId=PRO_0000204685. FT MOTIF 698 700 Microbody targeting signal (By FT similarity). FT COMPBIAS 340 343 Poly-Glu. FT VAR_SEQ 610 624 GGYFSGEQAGEVLES -> AERRCSCPGRRDRSS (in FT isoform 2). FT /FTId=VSP_023355. FT VAR_SEQ 625 700 Missing (in isoform 2). FT /FTId=VSP_023356. FT VARIANT 34 34 E -> A (in dbSNP:rs12513296). FT /FTId=VAR_030802. FT VARIANT 497 497 D -> N (in dbSNP:rs13434465). FT /FTId=VAR_030803. FT CONFLICT 34 35 EL -> DV (in Ref. 1; CAA72214). FT CONFLICT 44 45 ML -> NV (in Ref. 1; CAA72214). FT CONFLICT 95 95 D -> A (in Ref. 1; CAA72214). FT CONFLICT 365 365 A -> G (in Ref. 1; CAA72214). FT CONFLICT 601 601 S -> K (in Ref. 1; CAA72214). SQ SEQUENCE 700 AA; 77629 MW; 40D1CD3DC6A620C1 CRC64; MASTVEGGDT ALLPEFPRGP LDAYRARASF SWKELALFTE GEGMLRFKKT IFSALENDPL FARSPGADLS LEKYRELNFL RCKRIFEYDF LSVEDMFKSP LKVPALIQCL GMYDSSLAAK YLLHSLVFGS AVYSSGSERH LTYIQKIFRM EIFGCFALTE LSHGSNTKAI RTTAHYDPAT EEFIIHSPDF EAAKFWVGNM GKTATHAVVF AKLCVPGDQC HGLHPFIVQI RDPKTLLPMP GVMVGDIGKK LGQNGLDNGF AMFHKVRVPR QSLLNRMGDV TPEGTYVSPF KDVRQRFGAS LGSLSSGRVS IVSLAILNLK LAVAIALRFS ATRRQFGPTE EEEIPVLEYP MQQWRLLPYL AAVYALDHFS KSLFLDLVEL QRGLASGDRS ARQAELGREI HALASASKPL ASWTTQQGIQ ECREACGGHG YLAMNRLGVL RDDNDPNCTY EGDNNILLQQ TSNYLLGLLA HQVHDGACFR SPLKSVDFLD AYPGILDQKF EVSSVADCLD SAVALAAYKW LVCYLLRETY QKLNQEKRSG SSDFEARNKC QVSHGRPLAL AFVELTVVQR FHEHVHQPSV PPSLRAVLGR LSALYALWSL SRHAALLYRG GYFSGEQAGE VLESAVLALC SQLKDDAVAL VDVIAPPDFV LDSPIGRADG ELYKNLWGAV LQESKVLERA SWWPEFSVNK PVIGSLKSKL //