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O15254

- ACOX3_HUMAN

UniProt

O15254 - ACOX3_HUMAN

Protein

Peroxisomal acyl-coenzyme A oxidase 3

Gene

ACOX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Oxidizes the CoA-esters of 2-methyl-branched fatty acids.By similarity

    Catalytic activityi

    Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

    Cofactori

    FAD.By similarity

    Pathwayi

    GO - Molecular functioni

    1. acyl-CoA dehydrogenase activity Source: InterPro
    2. flavin adenine dinucleotide binding Source: InterPro
    3. pristanoyl-CoA oxidase activity Source: Reactome
    4. receptor binding Source: UniProtKB

    GO - Biological processi

    1. cellular lipid metabolic process Source: Reactome
    2. fatty acid beta-oxidation using acyl-CoA oxidase Source: Reactome
    3. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    ReactomeiREACT_17017. Beta-oxidation of pristanoyl-CoA.
    UniPathwayiUPA00661.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal acyl-coenzyme A oxidase 3 (EC:1.3.3.6)
    Alternative name(s):
    Branched-chain acyl-CoA oxidase
    Short name:
    BRCACox
    Pristanoyl-CoA oxidase
    Gene namesi
    Name:ACOX3
    Synonyms:BRCOX, PRCOX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:121. ACOX3.

    Subcellular locationi

    Peroxisome Curated

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. mitochondrion Source: Ensembl
    3. peroxisomal matrix Source: Reactome
    4. peroxisome Source: UniProtKB

    Keywords - Cellular componenti

    Peroxisome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24445.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 700699Peroxisomal acyl-coenzyme A oxidase 3PRO_0000204685Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications
    Modified residuei281 – 2811Phosphothreonine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO15254.
    PaxDbiO15254.
    PRIDEiO15254.

    PTM databases

    PhosphoSiteiO15254.

    Expressioni

    Gene expression databases

    ArrayExpressiO15254.
    BgeeiO15254.
    CleanExiHS_ACOX3.
    GenevestigatoriO15254.

    Organism-specific databases

    HPAiHPA035840.
    HPA035841.

    Interactioni

    Protein-protein interaction databases

    BioGridi113907. 3 interactions.
    IntActiO15254. 1 interaction.
    MINTiMINT-1192218.
    STRINGi9606.ENSP00000348775.

    Structurei

    3D structure databases

    ProteinModelPortaliO15254.
    SMRiO15254. Positions 123-673.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi698 – 7003Microbody targeting signalBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi340 – 3434Poly-Glu

    Sequence similaritiesi

    Belongs to the acyl-CoA oxidase family.Curated

    Phylogenomic databases

    eggNOGiCOG1960.
    HOGENOMiHOG000245077.
    HOVERGENiHBG101107.
    InParanoidiO15254.
    KOiK00232.
    OMAiWYLLENG.
    OrthoDBiEOG744T8F.
    PhylomeDBiO15254.
    TreeFamiTF314226.

    Family and domain databases

    Gene3Di2.40.110.10. 1 hit.
    InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR012258. Acyl-CoA_oxidase.
    IPR002655. Acyl-CoA_oxidase_C.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view]
    PfamiPF01756. ACOX. 1 hit.
    PF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
    SUPFAMiSSF47203. SSF47203. 2 hits.
    SSF56645. SSF56645. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O15254-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASTVEGGDT ALLPEFPRGP LDAYRARASF SWKELALFTE GEGMLRFKKT    50
    IFSALENDPL FARSPGADLS LEKYRELNFL RCKRIFEYDF LSVEDMFKSP 100
    LKVPALIQCL GMYDSSLAAK YLLHSLVFGS AVYSSGSERH LTYIQKIFRM 150
    EIFGCFALTE LSHGSNTKAI RTTAHYDPAT EEFIIHSPDF EAAKFWVGNM 200
    GKTATHAVVF AKLCVPGDQC HGLHPFIVQI RDPKTLLPMP GVMVGDIGKK 250
    LGQNGLDNGF AMFHKVRVPR QSLLNRMGDV TPEGTYVSPF KDVRQRFGAS 300
    LGSLSSGRVS IVSLAILNLK LAVAIALRFS ATRRQFGPTE EEEIPVLEYP 350
    MQQWRLLPYL AAVYALDHFS KSLFLDLVEL QRGLASGDRS ARQAELGREI 400
    HALASASKPL ASWTTQQGIQ ECREACGGHG YLAMNRLGVL RDDNDPNCTY 450
    EGDNNILLQQ TSNYLLGLLA HQVHDGACFR SPLKSVDFLD AYPGILDQKF 500
    EVSSVADCLD SAVALAAYKW LVCYLLRETY QKLNQEKRSG SSDFEARNKC 550
    QVSHGRPLAL AFVELTVVQR FHEHVHQPSV PPSLRAVLGR LSALYALWSL 600
    SRHAALLYRG GYFSGEQAGE VLESAVLALC SQLKDDAVAL VDVIAPPDFV 650
    LDSPIGRADG ELYKNLWGAV LQESKVLERA SWWPEFSVNK PVIGSLKSKL 700
    Length:700
    Mass (Da):77,629
    Last modified:February 20, 2007 - v2
    Checksum:i40D1CD3DC6A620C1
    GO
    Isoform 2 (identifier: O15254-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         610-624: GGYFSGEQAGEVLES → AERRCSCPGRRDRSS
         625-700: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:624
    Mass (Da):69,575
    Checksum:i1894338CCBF1939A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 352EL → DV in CAA72214. (PubMed:9271077)Curated
    Sequence conflicti44 – 452ML → NV in CAA72214. (PubMed:9271077)Curated
    Sequence conflicti95 – 951D → A in CAA72214. (PubMed:9271077)Curated
    Sequence conflicti365 – 3651A → G in CAA72214. (PubMed:9271077)Curated
    Sequence conflicti601 – 6011S → K in CAA72214. (PubMed:9271077)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti34 – 341E → A.
    Corresponds to variant rs12513296 [ dbSNP | Ensembl ].
    VAR_030802
    Natural varianti497 – 4971D → N.
    Corresponds to variant rs13434465 [ dbSNP | Ensembl ].
    VAR_030803

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei610 – 62415GGYFS…EVLES → AERRCSCPGRRDRSS in isoform 2. 1 PublicationVSP_023355Add
    BLAST
    Alternative sequencei625 – 70076Missing in isoform 2. 1 PublicationVSP_023356Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11411 mRNA. Translation: CAA72214.1.
    BC017053 mRNA. Translation: AAH17053.1.
    CCDSiCCDS3401.1. [O15254-1]
    CCDS47017.1. [O15254-2]
    RefSeqiNP_001095137.1. NM_001101667.1. [O15254-2]
    NP_003492.2. NM_003501.2. [O15254-1]
    XP_005248068.1. XM_005248011.2. [O15254-1]
    XP_005248070.1. XM_005248013.2. [O15254-2]
    UniGeneiHs.479122.

    Genome annotation databases

    EnsembliENST00000356406; ENSP00000348775; ENSG00000087008. [O15254-1]
    ENST00000413009; ENSP00000413994; ENSG00000087008. [O15254-2]
    ENST00000503233; ENSP00000421625; ENSG00000087008. [O15254-1]
    GeneIDi8310.
    KEGGihsa:8310.
    UCSCiuc003glc.4. human. [O15254-1]
    uc003gld.4. human. [O15254-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11411 mRNA. Translation: CAA72214.1 .
    BC017053 mRNA. Translation: AAH17053.1 .
    CCDSi CCDS3401.1. [O15254-1 ]
    CCDS47017.1. [O15254-2 ]
    RefSeqi NP_001095137.1. NM_001101667.1. [O15254-2 ]
    NP_003492.2. NM_003501.2. [O15254-1 ]
    XP_005248068.1. XM_005248011.2. [O15254-1 ]
    XP_005248070.1. XM_005248013.2. [O15254-2 ]
    UniGenei Hs.479122.

    3D structure databases

    ProteinModelPortali O15254.
    SMRi O15254. Positions 123-673.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113907. 3 interactions.
    IntActi O15254. 1 interaction.
    MINTi MINT-1192218.
    STRINGi 9606.ENSP00000348775.

    PTM databases

    PhosphoSitei O15254.

    Proteomic databases

    MaxQBi O15254.
    PaxDbi O15254.
    PRIDEi O15254.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356406 ; ENSP00000348775 ; ENSG00000087008 . [O15254-1 ]
    ENST00000413009 ; ENSP00000413994 ; ENSG00000087008 . [O15254-2 ]
    ENST00000503233 ; ENSP00000421625 ; ENSG00000087008 . [O15254-1 ]
    GeneIDi 8310.
    KEGGi hsa:8310.
    UCSCi uc003glc.4. human. [O15254-1 ]
    uc003gld.4. human. [O15254-2 ]

    Organism-specific databases

    CTDi 8310.
    GeneCardsi GC04M008368.
    HGNCi HGNC:121. ACOX3.
    HPAi HPA035840.
    HPA035841.
    MIMi 603402. gene.
    neXtProti NX_O15254.
    PharmGKBi PA24445.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1960.
    HOGENOMi HOG000245077.
    HOVERGENi HBG101107.
    InParanoidi O15254.
    KOi K00232.
    OMAi WYLLENG.
    OrthoDBi EOG744T8F.
    PhylomeDBi O15254.
    TreeFami TF314226.

    Enzyme and pathway databases

    UniPathwayi UPA00661 .
    Reactomei REACT_17017. Beta-oxidation of pristanoyl-CoA.

    Miscellaneous databases

    ChiTaRSi ACOX3. human.
    GeneWikii ACOX3.
    GenomeRNAii 8310.
    NextBioi 31121.
    PROi O15254.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15254.
    Bgeei O15254.
    CleanExi HS_ACOX3.
    Genevestigatori O15254.

    Family and domain databases

    Gene3Di 2.40.110.10. 1 hit.
    InterProi IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR012258. Acyl-CoA_oxidase.
    IPR002655. Acyl-CoA_oxidase_C.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view ]
    Pfami PF01756. ACOX. 1 hit.
    PF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000168. Acyl-CoA_oxidase. 1 hit.
    SUPFAMi SSF47203. SSF47203. 2 hits.
    SSF56645. SSF56645. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Evidence for the existence of a pristanoyl-CoA oxidase gene in man."
      Vanhooren J.C.T., Marynen P., Mannaerts G.P., van Veldhoven P.P.
      Biochem. J. 325:593-599(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Uterus.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-281, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiACOX3_HUMAN
    AccessioniPrimary (citable) accession number: O15254
    Secondary accession number(s): Q96AJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3