Peroxisomal acyl-coenzyme A oxidase 3

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Molecule processing

Regions

Natural variations

Experimental info

Molecule processing

Regions

Natural variations

Experimental info

Sequence databases

3D structure databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

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Reviewed, UniProtKB/Swiss-Prot O15254 (ACOX3_HUMAN)

Last modified June 16, 2009. Version 77. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Protein names

Recommended name:
    Peroxisomal acyl-coenzyme A oxidase 3
    EC=1.3.3.6
Alternative name(s):
    Pristanoyl-CoA oxidase
    Branched-chain acyl-CoA oxidase
      Short name=BRCACox

Gene names

Name:	ACOX3
Synonyms:	BRCOX, PRCOX

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Sequence length	700 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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Function	Oxidizes the CoA-esters of 2-methyl-branched fatty acids By similarity.
Catalytic activity	Acyl-CoA + O₂ = trans-2,3-dehydroacyl-CoA + H₂O₂.
Cofactor	FAD By similarity.
Pathway	Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Subcellular location	Peroxisome Potential.
Sequence similarities	Belongs to the acyl-CoA oxidase family.

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Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Peroxisome
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	bile acid metabolic process Ref.1 Traceable author statement. Source: ProtInc fatty acid beta-oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Ref.1 Traceable author statement. Source: ProtInc
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro acyl-CoA oxidase activity Ref.1 Traceable author statement. Source: ProtInc electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Chain

1 – 700

700

Peroxisomal acyl-coenzyme A oxidase 3

PRO_0000204685

Motif

698 – 700

Microbody targeting signal By similarity

Compositional bias

340 – 343

Poly-Glu

Alternative sequence

610 – 624

GGYFS…EVLES → AERRCSCPGRRDRSS in isoform 2.

VSP_023355

Alternative sequence

625 – 700

Missing in isoform 2.

VSP_023356

Natural variant

E → A: dbSNP rs12513296.

VAR_030802

Natural variant

497

D → N: dbSNP rs13434465.

VAR_030803

Sequence conflict

34 – 35

EL → DV in CAA72214. Ref.1

Sequence conflict

44 – 45

ML → NV in CAA72214. Ref.1

Sequence conflict

D → A in CAA72214. Ref.1

Sequence conflict

365

A → G in CAA72214. Ref.1

Sequence conflict

601

S → K in CAA72214. Ref.1

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Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: 40D1CD3DC6A620C1 Show »	FASTA	700	77,629
10 20 30 40 50 60 MASTVEGGDT ALLPEFPRGP LDAYRARASF SWKELALFTE GEGMLRFKKT IFSALENDPL 70 80 90 100 110 120 FARSPGADLS LEKYRELNFL RCKRIFEYDF LSVEDMFKSP LKVPALIQCL GMYDSSLAAK 130 140 150 160 170 180 YLLHSLVFGS AVYSSGSERH LTYIQKIFRM EIFGCFALTE LSHGSNTKAI RTTAHYDPAT 190 200 210 220 230 240 EEFIIHSPDF EAAKFWVGNM GKTATHAVVF AKLCVPGDQC HGLHPFIVQI RDPKTLLPMP 250 260 270 280 290 300 GVMVGDIGKK LGQNGLDNGF AMFHKVRVPR QSLLNRMGDV TPEGTYVSPF KDVRQRFGAS 310 320 330 340 350 360 LGSLSSGRVS IVSLAILNLK LAVAIALRFS ATRRQFGPTE EEEIPVLEYP MQQWRLLPYL 370 380 390 400 410 420 AAVYALDHFS KSLFLDLVEL QRGLASGDRS ARQAELGREI HALASASKPL ASWTTQQGIQ 430 440 450 460 470 480 ECREACGGHG YLAMNRLGVL RDDNDPNCTY EGDNNILLQQ TSNYLLGLLA HQVHDGACFR 490 500 510 520 530 540 SPLKSVDFLD AYPGILDQKF EVSSVADCLD SAVALAAYKW LVCYLLRETY QKLNQEKRSG 550 560 570 580 590 600 SSDFEARNKC QVSHGRPLAL AFVELTVVQR FHEHVHQPSV PPSLRAVLGR LSALYALWSL 610 620 630 640 650 660 SRHAALLYRG GYFSGEQAGE VLESAVLALC SQLKDDAVAL VDVIAPPDFV LDSPIGRADG 670 680 690 700 ELYKNLWGAV LQESKVLERA SWWPEFSVNK PVIGSLKSKL « Hide
Isoform 2. Checksum: 1894338CCBF1939A Show »	FASTA	624	69,575
10 20 30 40 50 60 MASTVEGGDT ALLPEFPRGP LDAYRARASF SWKELALFTE GEGMLRFKKT IFSALENDPL 70 80 90 100 110 120 FARSPGADLS LEKYRELNFL RCKRIFEYDF LSVEDMFKSP LKVPALIQCL GMYDSSLAAK 130 140 150 160 170 180 YLLHSLVFGS AVYSSGSERH LTYIQKIFRM EIFGCFALTE LSHGSNTKAI RTTAHYDPAT 190 200 210 220 230 240 EEFIIHSPDF EAAKFWVGNM GKTATHAVVF AKLCVPGDQC HGLHPFIVQI RDPKTLLPMP 250 260 270 280 290 300 GVMVGDIGKK LGQNGLDNGF AMFHKVRVPR QSLLNRMGDV TPEGTYVSPF KDVRQRFGAS 310 320 330 340 350 360 LGSLSSGRVS IVSLAILNLK LAVAIALRFS ATRRQFGPTE EEEIPVLEYP MQQWRLLPYL 370 380 390 400 410 420 AAVYALDHFS KSLFLDLVEL QRGLASGDRS ARQAELGREI HALASASKPL ASWTTQQGIQ 430 440 450 460 470 480 ECREACGGHG YLAMNRLGVL RDDNDPNCTY EGDNNILLQQ TSNYLLGLLA HQVHDGACFR 490 500 510 520 530 540 SPLKSVDFLD AYPGILDQKF EVSSVADCLD SAVALAAYKW LVCYLLRETY QKLNQEKRSG 550 560 570 580 590 600 SSDFEARNKC QVSHGRPLAL AFVELTVVQR FHEHVHQPSV PPSLRAVLGR LSALYALWSL 610 620 SRHAALLYRA ERRCSCPGRR DRSS « Hide

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	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evidence for the existence of a pristanoyl-CoA oxidase gene in man." Vanhooren J.C.T., Marynen P., Mannaerts G.P., van Veldhoven P.P. Biochem. J. 325:593-599(1997) [PubMed: 9271077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Uterus.
+	Additional computationally mapped references.

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Sequence databases
	Y11411 mRNA. Translation: CAA72214.1. BC017053 mRNA. Translation: AAH17053.1.
IPI	IPI00020226. IPI00827610.
RefSeq	NP_001095137.1. NP_003492.2.
UniGene	Hs.479122
3D structure databases
HSSP	HSSP built from PDB template 1IS2 based on UniProtKB P07872.
ModBase	Search...
Proteomic databases
PRIDE	O15254.
Genome annotation databases
Ensembl	ENSG00000087008. Homo sapiens. [Contig view]
GeneID	8310.
KEGG	hsa:8310.
Organism-specific databases
GeneCards	GC04M008486.
H-InvDB	HIX0004086.
HGNC	HGNC:121. ACOX3.
MIM	603402. gene.
PharmGKB	PA24445.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O15254.
HOVERGEN	O15254.
OMA	O15254. ALYGLWS.
Enzyme and pathway databases
BRENDA	1.3.3.6. 247.
Gene expression databases
ArrayExpress	O15254.
Bgee	O15254.
CleanEx	HS_ACOX3.
GermOnline	ENSG00000087008. Homo sapiens.
Family and domain databases
InterPro	IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_M. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHER	PTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
Pfam	PF01756. ACOX. 1 hit. PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
PIRSF	PIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	31121.
SOURCE	Search...

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Entry name

ACOX3_HUMAN

Accession

Primary (citable) accession number: O15254
Secondary accession number(s): Q96AJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	February 20, 2007
Last modified:	June 16, 2009
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O15254-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O15254-2)

The sequence of this isoform differs from the canonical sequence as follows:
610-624: GGYFSGEQAGEVLES → AERRCSCPGRRDRSS
625-700: Missing.

Note: No experimental confirmation available.