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O15254 (ACOX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal acyl-coenzyme A oxidase 3

EC=1.3.3.6
Alternative name(s):
Branched-chain acyl-CoA oxidase
Short name=BRCACox
Pristanoyl-CoA oxidase
Gene names
Name:ACOX3
Synonyms:BRCOX, PRCOX
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length700 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Oxidizes the CoA-esters of 2-methyl-branched fatty acids By similarity. Ref.1

Catalytic activity

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactor

FAD By similarity.

Pathway

Lipid metabolism; peroxisomal fatty acid beta-oxidation.

Subcellular location

Peroxisome Potential.

Sequence similarities

Belongs to the acyl-CoA oxidase family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O15254-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O15254-2)

The sequence of this isoform differs from the canonical sequence as follows:
     610-624: GGYFSGEQAGEVLES → AERRCSCPGRRDRSS
     625-700: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 700699Peroxisomal acyl-coenzyme A oxidase 3
PRO_0000204685

Regions

Motif698 – 7003Microbody targeting signal By similarity
Compositional bias340 – 3434Poly-Glu

Amino acid modifications

Modified residue21N-acetylalanine Ref.4 Ref.5
Modified residue2811Phosphothreonine Ref.3

Natural variations

Alternative sequence610 – 62415GGYFS…EVLES → AERRCSCPGRRDRSS in isoform 2.
VSP_023355
Alternative sequence625 – 70076Missing in isoform 2.
VSP_023356
Natural variant341E → A.
Corresponds to variant rs12513296 [ dbSNP | Ensembl ].
VAR_030802
Natural variant4971D → N.
Corresponds to variant rs13434465 [ dbSNP | Ensembl ].
VAR_030803

Experimental info

Sequence conflict34 – 352EL → DV in CAA72214. Ref.1
Sequence conflict44 – 452ML → NV in CAA72214. Ref.1
Sequence conflict951D → A in CAA72214. Ref.1
Sequence conflict3651A → G in CAA72214. Ref.1
Sequence conflict6011S → K in CAA72214. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: 40D1CD3DC6A620C1

FASTA70077,629
        10         20         30         40         50         60 
MASTVEGGDT ALLPEFPRGP LDAYRARASF SWKELALFTE GEGMLRFKKT IFSALENDPL 

        70         80         90        100        110        120 
FARSPGADLS LEKYRELNFL RCKRIFEYDF LSVEDMFKSP LKVPALIQCL GMYDSSLAAK 

       130        140        150        160        170        180 
YLLHSLVFGS AVYSSGSERH LTYIQKIFRM EIFGCFALTE LSHGSNTKAI RTTAHYDPAT 

       190        200        210        220        230        240 
EEFIIHSPDF EAAKFWVGNM GKTATHAVVF AKLCVPGDQC HGLHPFIVQI RDPKTLLPMP 

       250        260        270        280        290        300 
GVMVGDIGKK LGQNGLDNGF AMFHKVRVPR QSLLNRMGDV TPEGTYVSPF KDVRQRFGAS 

       310        320        330        340        350        360 
LGSLSSGRVS IVSLAILNLK LAVAIALRFS ATRRQFGPTE EEEIPVLEYP MQQWRLLPYL 

       370        380        390        400        410        420 
AAVYALDHFS KSLFLDLVEL QRGLASGDRS ARQAELGREI HALASASKPL ASWTTQQGIQ 

       430        440        450        460        470        480 
ECREACGGHG YLAMNRLGVL RDDNDPNCTY EGDNNILLQQ TSNYLLGLLA HQVHDGACFR 

       490        500        510        520        530        540 
SPLKSVDFLD AYPGILDQKF EVSSVADCLD SAVALAAYKW LVCYLLRETY QKLNQEKRSG 

       550        560        570        580        590        600 
SSDFEARNKC QVSHGRPLAL AFVELTVVQR FHEHVHQPSV PPSLRAVLGR LSALYALWSL 

       610        620        630        640        650        660 
SRHAALLYRG GYFSGEQAGE VLESAVLALC SQLKDDAVAL VDVIAPPDFV LDSPIGRADG 

       670        680        690        700 
ELYKNLWGAV LQESKVLERA SWWPEFSVNK PVIGSLKSKL 

« Hide

Isoform 2 [UniParc].

Checksum: 1894338CCBF1939A
Show »

FASTA62469,575

References

« Hide 'large scale' references
[1]"Evidence for the existence of a pristanoyl-CoA oxidase gene in man."
Vanhooren J.C.T., Marynen P., Mannaerts G.P., van Veldhoven P.P.
Biochem. J. 325:593-599(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Uterus.
[3]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-281, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[4]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[5]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y11411 mRNA. Translation: CAA72214.1.
BC017053 mRNA. Translation: AAH17053.1.
CCDSCCDS3401.1. [O15254-1]
CCDS47017.1. [O15254-2]
RefSeqNP_001095137.1. NM_001101667.1. [O15254-2]
NP_003492.2. NM_003501.2. [O15254-1]
XP_005248068.1. XM_005248011.2. [O15254-1]
XP_005248070.1. XM_005248013.2. [O15254-2]
UniGeneHs.479122.

3D structure databases

ProteinModelPortalO15254.
SMRO15254. Positions 123-673.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113907. 3 interactions.
IntActO15254. 1 interaction.
MINTMINT-1192218.
STRING9606.ENSP00000348775.

PTM databases

PhosphoSiteO15254.

Proteomic databases

MaxQBO15254.
PaxDbO15254.
PRIDEO15254.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000356406; ENSP00000348775; ENSG00000087008. [O15254-1]
ENST00000413009; ENSP00000413994; ENSG00000087008. [O15254-2]
ENST00000503233; ENSP00000421625; ENSG00000087008. [O15254-1]
GeneID8310.
KEGGhsa:8310.
UCSCuc003glc.4. human. [O15254-1]
uc003gld.4. human. [O15254-2]

Organism-specific databases

CTD8310.
GeneCardsGC04M008368.
HGNCHGNC:121. ACOX3.
HPAHPA035840.
HPA035841.
MIM603402. gene.
neXtProtNX_O15254.
PharmGKBPA24445.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1960.
HOGENOMHOG000245077.
HOVERGENHBG101107.
InParanoidO15254.
KOK00232.
OMAWYLLENG.
OrthoDBEOG744T8F.
PhylomeDBO15254.
TreeFamTF314226.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
UniPathwayUPA00661.

Gene expression databases

ArrayExpressO15254.
BgeeO15254.
CleanExHS_ACOX3.
GenevestigatorO15254.

Family and domain databases

Gene3D2.40.110.10. 1 hit.
InterProIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamPF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
PIRSFPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNetSearch...

Other

ChiTaRSACOX3. human.
GeneWikiACOX3.
GenomeRNAi8310.
NextBio31121.
PROO15254.
SOURCESearch...

Entry information

Entry nameACOX3_HUMAN
AccessionPrimary (citable) accession number: O15254
Secondary accession number(s): Q96AJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM