Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot O15254 (ACOX3_HUMAN)

Last modified February 9, 2010. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Peroxisomal acyl-coenzyme A oxidase 3
    EC=1.3.3.6
Alternative name(s):
    Pristanoyl-CoA oxidase
    Branched-chain acyl-CoA oxidase
      Short name=BRCACox
Gene names
Name: ACOX3
Synonyms: BRCOX, PRCOX
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length700 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Oxidizes the CoA-esters of 2-methyl-branched fatty acids By similarity. Ref.1

Catalytic activity

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactor

FAD By similarity.

Pathway

Lipid metabolism; peroxisomal fatty acid beta-oxidation.

Subcellular location

Peroxisome Potential.

Sequence similarities

Belongs to the acyl-CoA oxidase family.

Hide | Top

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentPeroxisome
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processbile acid metabolic process Ref.1

Traceable author statement. Source: ProtInc

fatty acid beta-oxidation

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentperoxisome Ref.1

Traceable author statement. Source: ProtInc

   Molecular functionFAD binding

Inferred from electronic annotation. Source: InterPro

acyl-CoA dehydrogenase activity

Inferred from electronic annotation. Source: InterPro

acyl-CoA oxidase activity Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

Hide | Top

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O15254-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O15254-2)

The sequence of this isoform differs from the canonical sequence as follows:
     610-624: GGYFSGEQAGEVLES → AERRCSCPGRRDRSS
     625-700: Missing.
Note: No experimental confirmation available.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 700700Peroxisomal acyl-coenzyme A oxidase 3
PRO_0000204685

Regions

Motif698 – 7003Microbody targeting signal By similarity
Compositional bias340 – 3434Poly-Glu

Amino acid modifications

Modified residue2811Phosphothreonine

Natural variations

Alternative sequence610 – 62415GGYFS…EVLES → AERRCSCPGRRDRSS in isoform 2.
VSP_023355
Alternative sequence625 – 70076Missing in isoform 2.
VSP_023356
Natural variant341E → A: dbSNP rs12513296.
VAR_030802
Natural variant4971D → N: dbSNP rs13434465.
VAR_030803

Experimental info

Sequence conflict34 – 352EL → DV in CAA72214. Ref.1
Sequence conflict44 – 452ML → NV in CAA72214. Ref.1
Sequence conflict951D → A in CAA72214. Ref.1
Sequence conflict3651A → G in CAA72214. Ref.1
Sequence conflict6011S → K in CAA72214. Ref.1

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: 40D1CD3DC6A620C1

FASTA70077,629
        10         20         30         40         50         60 
MASTVEGGDT ALLPEFPRGP LDAYRARASF SWKELALFTE GEGMLRFKKT IFSALENDPL 

        70         80         90        100        110        120 
FARSPGADLS LEKYRELNFL RCKRIFEYDF LSVEDMFKSP LKVPALIQCL GMYDSSLAAK 

       130        140        150        160        170        180 
YLLHSLVFGS AVYSSGSERH LTYIQKIFRM EIFGCFALTE LSHGSNTKAI RTTAHYDPAT 

       190        200        210        220        230        240 
EEFIIHSPDF EAAKFWVGNM GKTATHAVVF AKLCVPGDQC HGLHPFIVQI RDPKTLLPMP 

       250        260        270        280        290        300 
GVMVGDIGKK LGQNGLDNGF AMFHKVRVPR QSLLNRMGDV TPEGTYVSPF KDVRQRFGAS 

       310        320        330        340        350        360 
LGSLSSGRVS IVSLAILNLK LAVAIALRFS ATRRQFGPTE EEEIPVLEYP MQQWRLLPYL 

       370        380        390        400        410        420 
AAVYALDHFS KSLFLDLVEL QRGLASGDRS ARQAELGREI HALASASKPL ASWTTQQGIQ 

       430        440        450        460        470        480 
ECREACGGHG YLAMNRLGVL RDDNDPNCTY EGDNNILLQQ TSNYLLGLLA HQVHDGACFR 

       490        500        510        520        530        540 
SPLKSVDFLD AYPGILDQKF EVSSVADCLD SAVALAAYKW LVCYLLRETY QKLNQEKRSG 

       550        560        570        580        590        600 
SSDFEARNKC QVSHGRPLAL AFVELTVVQR FHEHVHQPSV PPSLRAVLGR LSALYALWSL 

       610        620        630        640        650        660 
SRHAALLYRG GYFSGEQAGE VLESAVLALC SQLKDDAVAL VDVIAPPDFV LDSPIGRADG 

       670        680        690        700 
ELYKNLWGAV LQESKVLERA SWWPEFSVNK PVIGSLKSKL

« Hide

Isoform 2.

Checksum: 1894338CCBF1939A
Show »

FASTA62469,575

Hide | Top

References

« Hide 'large scale' references
[1]"Evidence for the existence of a pristanoyl-CoA oxidase gene in man."
Vanhooren J.C.T., Marynen P., Mannaerts G.P., van Veldhoven P.P.
Biochem. J. 325:593-599(1997) [PubMed: 9271077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Uterus.
[3]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-281, MASS SPECTROMETRY.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y11411 mRNA. Translation: CAA72214.1.
BC017053 mRNA. Translation: AAH17053.1.
IPIIPI00020226.
IPI00827610.
RefSeqNP_001095137.1.
NP_003492.2.
UniGeneHs.479122

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGO15254.

PTM databases

PhosphoSiteO15254.

Proteomic databases

PRIDEO15254.

Genome annotation databases

EnsemblENST00000356406; ENSP00000348775; ENSG00000087008; Homo sapiens. [Genome view]
GeneID8310.
KEGGhsa:8310.
UCSCuc003glc.2. human.
uc003gld.2. human.

Organism-specific databases

CTD8310.
GeneCardsGC04M008486.
H-InvDBHIX0004086.
HGNCHGNC:121. ACOX3.
MIM603402. gene.
PharmGKBPA24445.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG18371.
HOGENOMHBG383414.
HOVERGENO15254.
InParanoidO15254.
OMALEYQMQQ.
OrthoDBEOG9KM1P1.
PhylomeDBO15254.

Enzyme and pathway databases

BRENDA1.3.3.6. 247.
ReactomeREACT_602. Metabolism of lipids and lipoproteins.

Gene expression databases

ArrayExpressO15254.
BgeeO15254.
CleanExHS_ACOX3.
GenevestigatorO15254.
GermOnlineENSG00000087008. Homo sapiens.

Family and domain databases

InterProIPR006090. Acyl-CoA_Oxase/DH_1.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase.
IPR013764. AcylCoA_oxidase/DH_1/2_C.
[Graphical view]
Gene3DG3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit.
G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit.
G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHERPTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
PfamPF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
PIRSFPIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProtoNetSearch...

Other Resources

NextBio31121.
SOURCESearch...

Hide | Top

Entry information

Entry nameACOX3_HUMAN
AccessionPrimary (citable) accession number: O15254
Secondary accession number(s): Q96AJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: February 20, 2007
Last modified: February 9, 2010
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Hide | Top

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents