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O15245

- S22A1_HUMAN

UniProt

O15245 - S22A1_HUMAN

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Protein

Solute carrier family 22 member 1

Gene
SLC22A1, OCT1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.8 Publications

Kineticsi

  1. KM=1.47 mM for metformin3 Publications
  2. KM=229 µM for TEA
  3. KM=14.6 µM for MPP

Vmax=396 pmol/min/mg enzyme for metformin uptake

Vmax=2.89 nmol/min/mg enzyme for TEA uptake

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei450 – 4501Involved in affinity and selectivity of cations as well as in translocation By similarity

GO - Molecular functioni

  1. acetylcholine transmembrane transporter activity Source: Ensembl
  2. dopamine transmembrane transporter activity Source: Ensembl
  3. norepinephrine transmembrane transporter activity Source: Ensembl
  4. organic cation transmembrane transporter activity Source: UniProtKB
  5. protein binding Source: IntAct
  6. quaternary ammonium group transmembrane transporter activity Source: Ensembl
  7. secondary active organic cation transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. dopamine transport Source: Ensembl
  2. drug transmembrane transport Source: Reactome
  3. epinephrine transport Source: Ensembl
  4. establishment or maintenance of transmembrane electrochemical gradient Source: Ensembl
  5. norepinephrine transport Source: Ensembl
  6. organic cation transport Source: UniProtKB
  7. protein homooligomerization Source: Ensembl
  8. small molecule metabolic process Source: Reactome
  9. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_120801. Abacavir transmembrane transport.
REACT_13583. Neurotransmitter Clearance In The Synaptic Cleft.
REACT_15418. Norepinephrine Neurotransmitter Release Cycle.
REACT_20506. Na+/Cl- dependent neurotransmitter transporters.
REACT_22357. Organic cation transport.

Protein family/group databases

TCDBi2.A.1.19.29. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 1
Alternative name(s):
Organic cation transporter 1
Short name:
hOCT1
Gene namesi
Name:SLC22A1
Synonyms:OCT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:10963. SLC22A1.

Subcellular locationi

Basolateral cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei22 – 4221Helical; Reviewed predictionAdd
BLAST
Topological domaini43 – 149107Extracellular Reviewed predictionAdd
BLAST
Transmembranei150 – 17021Helical; Reviewed predictionAdd
BLAST
Topological domaini171 – 1766Cytoplasmic Reviewed prediction
Transmembranei177 – 19721Helical; Reviewed predictionAdd
BLAST
Topological domaini198 – 2069Extracellular Reviewed prediction
Transmembranei207 – 22923Helical; Reviewed predictionAdd
BLAST
Topological domaini230 – 2356Cytoplasmic Reviewed prediction
Transmembranei236 – 25621Helical; Reviewed predictionAdd
BLAST
Topological domaini257 – 2626Extracellular Reviewed prediction
Transmembranei263 – 28321Helical; Reviewed predictionAdd
BLAST
Topological domaini284 – 34764Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei348 – 36821Helical; Reviewed predictionAdd
BLAST
Topological domaini369 – 3768Extracellular Reviewed prediction
Transmembranei377 – 39721Helical; Reviewed predictionAdd
BLAST
Topological domaini398 – 4025Cytoplasmic Reviewed prediction
Transmembranei403 – 42321Helical; Reviewed predictionAdd
BLAST
Topological domaini424 – 4318Extracellular Reviewed prediction
Transmembranei432 – 45221Helical; Reviewed predictionAdd
BLAST
Topological domaini453 – 46412Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei465 – 48521Helical; Reviewed predictionAdd
BLAST
Topological domaini486 – 4927Extracellular Reviewed prediction
Transmembranei493 – 51321Helical; Reviewed predictionAdd
BLAST
Topological domaini514 – 55441Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: UniProtKB
  3. membrane Source: UniProtKB
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi465 – 4651G → A: No changes in the MPP uptake. 1 Publication

Organism-specific databases

PharmGKBiPA329.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Solute carrier family 22 member 1PRO_0000333875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO15245.
PRIDEiO15245.

PTM databases

PhosphoSiteiO15245.

Expressioni

Tissue specificityi

Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines.3 Publications

Inductioni

In the liver activated by HNF4A and suppressed by bile acids via NR0B2. Increased by cholesterol treatment in hepatocyte cells.2 Publications

Gene expression databases

ArrayExpressiO15245.
BgeeiO15245.
CleanExiHS_SLC22A1.
GenevestigatoriO15245.

Organism-specific databases

HPAiHPA029846.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CERS2Q96G233EBI-1172714,EBI-1057080

Protein-protein interaction databases

BioGridi112467. 1 interaction.
IntActiO15245. 1 interaction.
STRINGi9606.ENSP00000355930.

Structurei

3D structure databases

ProteinModelPortaliO15245.
SMRiO15245. Positions 153-518.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000234568.
HOVERGENiHBG061545.
InParanoidiO15245.
KOiK08198.
OMAiVCADSWK.
OrthoDBiEOG78PV8N.
PhylomeDBiO15245.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O15245-1) [UniParc]FASTAAdd to Basket

Also known as: hOCT1G/L554

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPTVDDILEQ VGESGWFQKQ AFLILCLLSA AFAPICVGIV FLGFTPDHHC    50
QSPGVAELSQ RCGWSPAEEL NYTVPGLGPA GEAFLGQCRR YEVDWNQSAL 100
SCVDPLASLA TNRSHLPLGP CQDGWVYDTP GSSIVTEFNL VCADSWKLDL 150
FQSCLNAGFL FGSLGVGYFA DRFGRKLCLL GTVLVNAVSG VLMAFSPNYM 200
SMLLFRLLQG LVSKGNWMAG YTLITEFVGS GSRRTVAIMY QMAFTVGLVA 250
LTGLAYALPH WRWLQLAVSL PTFLFLLYYW CVPESPRWLL SQKRNTEAIK 300
IMDHIAQKNG KLPPADLKML SLEEDVTEKL SPSFADLFRT PRLRKRTFIL 350
MYLWFTDSVL YQGLILHMGA TSGNLYLDFL YSALVEIPGA FIALITIDRV 400
GRIYPMAMSN LLAGAACLVM IFISPDLHWL NIIIMCVGRM GITIAIQMIC 450
LVNAELYPTF VRNLGVMVCS SLCDIGGIIT PFIVFRLREV WQALPLILFA 500
VLGLLAAGVT LLLPETKGVA LPETMKDAEN LGRKAKPKEN TIYLKVQTSE 550
PSGT 554
Length:554
Mass (Da):61,154
Last modified:November 30, 2010 - v2
Checksum:i55206B897DE32202
GO
Isoform 2 (identifier: O15245-2) [UniParc]FASTAAdd to Basket

Also known as: hOCT1G/L506

The sequence of this isoform differs from the canonical sequence as follows:
     462-506: RNLGVMVCSS...ILFAVLGLLA → SGVGPACRGS...SKAQRKHDLP
     507-554: Missing.

Show »
Length:506
Mass (Da):56,094
Checksum:iFDD376F7F8547B5D
GO
Isoform 3 (identifier: O15245-3) [UniParc]FASTAAdd to Basket

Also known as: hOCT1G483

The sequence of this isoform differs from the canonical sequence as follows:
     462-532: Missing.

Show »
Length:483
Mass (Da):53,593
Checksum:i843CF89CFB1D9827
GO
Isoform 4 (identifier: O15245-4) [UniParc]FASTAAdd to Basket

Also known as: hOCT1G353

The sequence of this isoform differs from the canonical sequence as follows:
     354-554: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:353
Mass (Da):39,224
Checksum:i88073B911A5E5633
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141S → F Exclusively found in the African American population; increase of the MPP uptake; when associated with V-408. 1 Publication
Corresponds to variant rs34447885 [ dbSNP | Ensembl ].
VAR_043319
Natural varianti41 – 411F → L.1 Publication
Corresponds to variant rs2297373 [ dbSNP | Ensembl ].
VAR_043320
Natural varianti61 – 611R → C Reduction of the MPP uptake. Reduction of the MPP uptake; when associated with V-408. 2 Publications
Corresponds to variant rs12208357 [ dbSNP | Ensembl ].
VAR_043321
Natural varianti85 – 851L → F No changes in the MPP uptake; when associated with V-408. 1 Publication
Corresponds to variant rs35546288 [ dbSNP | Ensembl ].
VAR_043322
Natural varianti88 – 881C → R.1 Publication
Corresponds to variant rs55918055 [ dbSNP | Ensembl ].
VAR_043323
Natural varianti160 – 1601L → F No changes in both TEA and MPP uptake. No MPP uptake; when associated with S-401. Largely localized in the plasma membrane. 7 Publications
Corresponds to variant rs683369 [ dbSNP | Ensembl ].
VAR_043324
Natural varianti189 – 1891S → L No changes in the MPP uptake. No changes in the MPP uptake; when associated with V-408. 1 Publication
Corresponds to variant rs34104736 [ dbSNP | Ensembl ].
VAR_043325
Natural varianti220 – 2201G → V No MPP uptake. Reduction of the MPP uptake; when associated with V-408. 1 Publication
Corresponds to variant rs36103319 [ dbSNP | Ensembl ].
VAR_043326
Natural varianti283 – 2831P → L.1 Publication
Corresponds to variant rs4646277 [ dbSNP | Ensembl ].
VAR_043327
Natural varianti287 – 2871R → G.1 Publication
Corresponds to variant rs4646278 [ dbSNP | Ensembl ].
VAR_043328
Natural varianti341 – 3411P → L Reduction of the MPP uptake. Reduction of the MPP uptake; when associated with V-408. Partly reduction of TEA uptake. Largely localized in the plasma membrane. 3 Publications
Corresponds to variant rs2282143 [ dbSNP | Ensembl ].
VAR_043329
Natural varianti342 – 3421R → H No changes in the MPP uptake; when associated with V-408. 1 Publication
Corresponds to variant rs34205214 [ dbSNP | Ensembl ].
VAR_043330
Natural varianti401 – 4011G → S No MPP uptake. Reduction of the serotonin uptake. No MPP uptake; when associated with L-160. 2 Publications
Corresponds to variant rs34130495 [ dbSNP | Ensembl ].
VAR_043331
Natural varianti408 – 4081M → V No changes in the MPP uptake. No changes in the MPP uptake; when associated with F-14. No changes in the MPP uptake; when associated with F-85. No changes in the MPP uptake; when associated with L-189. No changes in the MPP uptake; when associated with His-342. No changes in the MPP uptake; when associated with M-420 del. No changes in the MPP uptake; when associated with I-440. No changes in the MPP uptake; when associated with I-461. No changes in the MPP uptake; when associated with M-488. Reduction of the MPP uptake; when associated with C-61. No MPP uptake; when associated with V-220. Reduction of the MPP uptake; when associated with L-341. No MPP uptake; when associated with S-401. No MPP uptake; when associated with R-465. 3 Publications
Corresponds to variant rs628031 [ dbSNP | Ensembl ].
VAR_043332
Natural varianti420 – 4201Missing No changes in the MPP uptake. No changes in the MPP uptake; when associated with V-408. 3 Publications
VAR_043333
Natural varianti440 – 4401M → I.1 Publication
Corresponds to variant rs35956182 [ dbSNP | Ensembl ].
VAR_043334
Natural varianti461 – 4611V → I No changes in the MPP uptake; when associated with V-408. 1 Publication
Corresponds to variant rs34295611 [ dbSNP | Ensembl ].
VAR_043335
Natural varianti465 – 4651G → R Reduction of the localization to the basolateral membrane. No MPP uptake; when associated with V-408. 2 Publications
Corresponds to variant rs34059508 [ dbSNP | Ensembl ].
VAR_043336
Natural varianti488 – 4881R → M No changes in the MPP uptake; when associated with V-408. 1 Publication
Corresponds to variant rs35270274 [ dbSNP | Ensembl ].
VAR_043337

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei354 – 554201Missing in isoform 4. VSP_033587Add
BLAST
Alternative sequencei462 – 53271Missing in isoform 3. VSP_033588Add
BLAST
Alternative sequencei462 – 50645RNLGV…LGLLA → SGVGPACRGSDATSSRDQGG RFARDHEGRREPWEKSKAQR KHDLP in isoform 2. VSP_033589Add
BLAST
Alternative sequencei507 – 55448Missing in isoform 2. VSP_033590Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98332 mRNA. Translation: CAA66977.1.
U77086 mRNA. Translation: AAB67703.1.
AJ243995
, AJ243996, AJ243998, AJ243999, AJ244000, AJ245460, AJ276051, AJ276052, AJ276053 Genomic DNA. Translation: CAB95971.1.
AK289887 mRNA. Translation: BAF82576.1.
AL353625 Genomic DNA. Translation: CAH72016.1.
BC126364 mRNA. Translation: AAI26365.1.
CCDSiCCDS5274.1. [O15245-1]
CCDS5275.1. [O15245-2]
RefSeqiNP_003048.1. NM_003057.2. [O15245-1]
NP_694857.1. NM_153187.1. [O15245-2]
XP_006715615.1. XM_006715552.1. [O15245-3]
UniGeneiHs.117367.

Genome annotation databases

EnsembliENST00000324965; ENSP00000318103; ENSG00000175003. [O15245-2]
ENST00000366963; ENSP00000355930; ENSG00000175003. [O15245-1]
ENST00000457470; ENSP00000409557; ENSG00000175003. [O15245-3]
ENST00000460902; ENSP00000439274; ENSG00000175003. [O15245-4]
GeneIDi6580.
KEGGihsa:6580.
UCSCiuc003qtc.3. human. [O15245-1]
uc003qtd.3. human. [O15245-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98332 mRNA. Translation: CAA66977.1 .
U77086 mRNA. Translation: AAB67703.1 .
AJ243995
, AJ243996 , AJ243998 , AJ243999 , AJ244000 , AJ245460 , AJ276051 , AJ276052 , AJ276053 Genomic DNA. Translation: CAB95971.1 .
AK289887 mRNA. Translation: BAF82576.1 .
AL353625 Genomic DNA. Translation: CAH72016.1 .
BC126364 mRNA. Translation: AAI26365.1 .
CCDSi CCDS5274.1. [O15245-1 ]
CCDS5275.1. [O15245-2 ]
RefSeqi NP_003048.1. NM_003057.2. [O15245-1 ]
NP_694857.1. NM_153187.1. [O15245-2 ]
XP_006715615.1. XM_006715552.1. [O15245-3 ]
UniGenei Hs.117367.

3D structure databases

ProteinModelPortali O15245.
SMRi O15245. Positions 153-518.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112467. 1 interaction.
IntActi O15245. 1 interaction.
STRINGi 9606.ENSP00000355930.

Chemistry

BindingDBi O15245.
ChEMBLi CHEMBL5685.

Protein family/group databases

TCDBi 2.A.1.19.29. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei O15245.

Proteomic databases

PaxDbi O15245.
PRIDEi O15245.

Protocols and materials databases

DNASUi 6580.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324965 ; ENSP00000318103 ; ENSG00000175003 . [O15245-2 ]
ENST00000366963 ; ENSP00000355930 ; ENSG00000175003 . [O15245-1 ]
ENST00000457470 ; ENSP00000409557 ; ENSG00000175003 . [O15245-3 ]
ENST00000460902 ; ENSP00000439274 ; ENSG00000175003 . [O15245-4 ]
GeneIDi 6580.
KEGGi hsa:6580.
UCSCi uc003qtc.3. human. [O15245-1 ]
uc003qtd.3. human. [O15245-2 ]

Organism-specific databases

CTDi 6580.
GeneCardsi GC06P160542.
HGNCi HGNC:10963. SLC22A1.
HPAi HPA029846.
MIMi 602607. gene.
neXtProti NX_O15245.
PharmGKBi PA329.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000234568.
HOVERGENi HBG061545.
InParanoidi O15245.
KOi K08198.
OMAi VCADSWK.
OrthoDBi EOG78PV8N.
PhylomeDBi O15245.
TreeFami TF315847.

Enzyme and pathway databases

Reactomei REACT_120801. Abacavir transmembrane transport.
REACT_13583. Neurotransmitter Clearance In The Synaptic Cleft.
REACT_15418. Norepinephrine Neurotransmitter Release Cycle.
REACT_20506. Na+/Cl- dependent neurotransmitter transporters.
REACT_22357. Organic cation transport.

Miscellaneous databases

GeneWikii SLC22A1.
GenomeRNAii 6580.
NextBioi 25603.
PROi O15245.
SOURCEi Search...

Gene expression databases

ArrayExpressi O15245.
Bgeei O15245.
CleanExi HS_SLC22A1.
Genevestigatori O15245.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00898. 2A0119. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT PHE-160.
    Tissue: Liver.
  2. "Cloning and functional expression of a human liver organic cation transporter."
    Zhang L., Dresser M.J., Gray A.T., Yost S.C., Terashita S., Giacomini K.M.
    Mol. Pharmacol. 51:913-921(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
  3. "Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1)."
    Hayer M., Boenisch H., Bruess M.
    Ann. Hum. Genet. 63:473-482(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3 AND 4).
  4. Erratum
    Hayer M., Bonisch H., Bruss M.
    Ann. Hum. Genet. 64:267-267(2000)
    Cited for: SEQUENCE REVISION.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS PHE-160; VAL-408; MET-420 DEL AND ARG-465.
    Tissue: Caudate nucleus.
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PHE-160.
  8. "Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa)."
    Zhang L., Schaner M.E., Giacomini K.M.
    J. Pharmacol. Exp. Ther. 286:354-361(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
  9. "Comparison of 'type I' and 'type II' organic cation transport by organic cation transporters and organic anion-transporting polypeptides."
    van Montfoort J.E., Mueller M., Groothuis G.M.M., Meijer D.K.F., Koepsell H., Meier P.J.
    J. Pharmacol. Exp. Ther. 298:110-115(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. Cited for: FUNCTION.
  11. "Drug specificity and intestinal membrane localization of human organic cation transporters (OCT)."
    Mueller J., Lips K.S., Metzner L., Neubert R.H.H., Koepsell H., Brandsch M.
    Biochem. Pharmacol. 70:1851-1860(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  12. "Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1."
    Kimura N., Masuda S., Tanihara Y., Ueo H., Okuda M., Katsura T., Inui K.
    Drug Metab. Pharmacokinet. 20:379-386(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
  13. "The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha."
    Saborowski M., Kullak-Ublick G.A., Eloranta J.J.
    J. Pharmacol. Exp. Ther. 317:778-785(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  14. "Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain."
    Amphoux A., Vialou V., Drescher E., Bruess M., Mannoury La Cour C., Rochat C., Millan M.J., Giros B., Boenisch H., Gautron S.
    Neuropharmacology 50:941-952(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells."
    Dias V., Ribeiro V.
    Fundam. Clin. Pharmacol. 21:445-450(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  16. "Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences."
    Kerb R., Brinkmann U., Chatskaia N., Gorbunov D., Gorboulev V., Mornhinweg E., Keil A., Eichelbaum M., Koepsell H.
    Pharmacogenetics 12:591-595(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CYS-61; ARG-88; PHE-160; SER-401 AND MET-420 DEL, CHARACTERIZATION OF VARIANTS CYS-61; ARG-88; PHE-160; SER-401 AND MET-420 DEL.
  17. Cited for: VARIANTS PHE-14; CYS-61; PHE-85; PHE-160; LEU-189; VAL-220; LEU-341; HIS-342; SER-401; VAL-408; MET-420 DEL; ILE-440; ILE-461; ARG-465 AND MET-488, CHARACTERIZATION OF VARIANTS PHE-14; CYS-61; PHE-85; PHE-160; LEU-189; VAL-220; LEU-341; HIS-342; SER-401; VAL-408; MET-420 DEL; ILE-440; ILE-461; ARG-465 AND MET-488, MUTAGENESIS OF GLY-465.
  18. "Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions."
    Sakata T., Anzai N., Shin H.J., Noshiro R., Hirata T., Yokoyama H., Kanai Y., Endou H.
    Biochem. Biophys. Res. Commun. 313:789-793(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PHE-160; LEU-283; GLY-287 AND LEU-341.
  19. "Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic cation transporter 1 (OCT1)."
    Itoda M., Saito Y., Maekawa K., Hichiya H., Komamura K., Kamakura S., Kitakaze M., Tomoike H., Ueno K., Ozawa S., Sawada J.
    Drug Metab. Pharmacokinet. 19:308-312(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LEU-41; PHE-160; LEU-341 AND VAL-408.

Entry informationi

Entry nameiS22A1_HUMAN
AccessioniPrimary (citable) accession number: O15245
Secondary accession number(s): A6NFF3
, A8K1H2, C9JSU6, O15395, Q9NQD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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