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Protein

Solute carrier family 22 member 1

Gene

SLC22A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.8 Publications

Kineticsi

  1. KM=1.47 mM for metformin3 Publications
  2. KM=229 µM for TEA3 Publications
  3. KM=14.6 µM for MPP3 Publications
  1. Vmax=396 pmol/min/mg enzyme for metformin uptake3 Publications
  2. Vmax=2.89 nmol/min/mg enzyme for TEA uptake3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei450Involved in affinity and selectivity of cations as well as in translocationBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-112311. Neurotransmitter Clearance In The Synaptic Cleft.
R-HSA-181430. Norepinephrine Neurotransmitter Release Cycle.
R-HSA-2161517. Abacavir transmembrane transport.
R-HSA-442660. Na+/Cl- dependent neurotransmitter transporters.
R-HSA-549127. Organic cation transport.

Protein family/group databases

TCDBi2.A.1.19.29. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 1
Alternative name(s):
Organic cation transporter 1
Short name:
hOCT1
Gene namesi
Name:SLC22A1
Synonyms:OCT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:10963. SLC22A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 149ExtracellularSequence analysisAdd BLAST107
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 176CytoplasmicSequence analysis6
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 206ExtracellularSequence analysis9
Transmembranei207 – 229HelicalSequence analysisAdd BLAST23
Topological domaini230 – 235CytoplasmicSequence analysis6
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 262ExtracellularSequence analysis6
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 347CytoplasmicSequence analysisAdd BLAST64
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 376ExtracellularSequence analysis8
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 402CytoplasmicSequence analysis5
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 431ExtracellularSequence analysis8
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Topological domaini453 – 464CytoplasmicSequence analysisAdd BLAST12
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Topological domaini486 – 492ExtracellularSequence analysis7
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 554CytoplasmicSequence analysisAdd BLAST41

GO - Cellular componenti

  • basolateral plasma membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi465G → A: No changes in the MPP uptake. 1 Publication1

Organism-specific databases

DisGeNETi6580.
OpenTargetsiENSG00000175003.
PharmGKBiPA329.

Chemistry databases

ChEMBLiCHEMBL5685.
DrugBankiDB01193. Acebutolol.
DB01614. Acepromazine.
DB03128. Acetylcholine.
DB00787. Aciclovir.
DB00915. Amantadine.
DB00594. Amiloride.
DB00345. Aminohippurate.
DB00520. Caspofungin.
DB01114. Chlorphenamine.
DB00477. Chlorpromazine.
DB00122. Choline.
DB00501. Cimetidine.
DB00242. Cladribine.
DB00575. Clonidine.
DB00318. Codeine.
DB00987. Cytarabine.
DB01151. Desipramine.
DB00917. Dinoprostone.
DB01075. Diphenhydramine.
DB00280. Disopyramide.
DB00988. Dopamine.
DB00668. Epinephrine.
DB00783. Estradiol.
DB04574. Estropipate.
DB01004. Ganciclovir.
DB00406. Gentian Violet.
DB00536. Guanidine.
DB00667. Histamine Phosphate.
DB00619. Imatinib.
DB00458. Imipramine.
DB00224. Indinavir.
DB00709. Lamivudine.
DB00654. Latanoprost.
DB00331. Metformin.
DB00683. Midazolam.
DB00220. Nelfinavir.
DB00184. Nicotine.
DB00368. Norepinephrine.
DB00526. Oxaliplatin.
DB01337. Pancuronium.
DB00914. Phenformin.
DB00925. Phenoxybenzamine.
DB01621. Pipotiazine.
DB00413. Pramipexole.
DB00457. Prazosin.
DB01032. Probenecid.
DB01035. Procainamide.
DB00396. Progesterone.
DB00908. Quinidine.
DB00468. Quinine.
DB00863. Ranitidine.
DB00206. Reserpine.
DB00728. Rocuronium.
DB01232. Saquinavir.
DB00127. Spermine.
DB00624. Testosterone.
DB00152. Thiamine.
DB01622. Thioproperazine.
DB01623. Thiothixene.
DB01199. Tubocurarine.
DB01339. Vecuronium.
DB00661. Verapamil.
GuidetoPHARMACOLOGYi1019.

Polymorphism and mutation databases

BioMutaiSLC22A1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003338751 – 554Solute carrier family 22 member 1Add BLAST554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Modified residuei333PhosphoserineBy similarity1
Modified residuei541PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO15245.
PeptideAtlasiO15245.
PRIDEiO15245.

PTM databases

iPTMnetiO15245.
PhosphoSitePlusiO15245.

Expressioni

Tissue specificityi

Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines.3 Publications

Inductioni

In the liver activated by HNF4A and suppressed by bile acids via NR0B2. Increased by cholesterol treatment in hepatocyte cells.2 Publications

Gene expression databases

BgeeiENSG00000175003.
CleanExiHS_SLC22A1.
ExpressionAtlasiO15245. baseline and differential.
GenevisibleiO15245. HS.

Organism-specific databases

HPAiHPA029846.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CERS2Q96G233EBI-1172714,EBI-1057080

Protein-protein interaction databases

BioGridi112467. 1 interactor.
IntActiO15245. 1 interactor.
STRINGi9606.ENSP00000355930.

Chemistry databases

BindingDBiO15245.

Structurei

3D structure databases

ProteinModelPortaliO15245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234568.
HOVERGENiHBG061545.
InParanoidiO15245.
KOiK08198.
OMAiDLFQSCL.
OrthoDBiEOG091G05AC.
PhylomeDBiO15245.
TreeFamiTF315847.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR004749. Orgcat_transp/SVOP.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15245-1) [UniParc]FASTAAdd to basket
Also known as: hOCT1G/L554

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPTVDDILEQ VGESGWFQKQ AFLILCLLSA AFAPICVGIV FLGFTPDHHC
60 70 80 90 100
QSPGVAELSQ RCGWSPAEEL NYTVPGLGPA GEAFLGQCRR YEVDWNQSAL
110 120 130 140 150
SCVDPLASLA TNRSHLPLGP CQDGWVYDTP GSSIVTEFNL VCADSWKLDL
160 170 180 190 200
FQSCLNAGFL FGSLGVGYFA DRFGRKLCLL GTVLVNAVSG VLMAFSPNYM
210 220 230 240 250
SMLLFRLLQG LVSKGNWMAG YTLITEFVGS GSRRTVAIMY QMAFTVGLVA
260 270 280 290 300
LTGLAYALPH WRWLQLAVSL PTFLFLLYYW CVPESPRWLL SQKRNTEAIK
310 320 330 340 350
IMDHIAQKNG KLPPADLKML SLEEDVTEKL SPSFADLFRT PRLRKRTFIL
360 370 380 390 400
MYLWFTDSVL YQGLILHMGA TSGNLYLDFL YSALVEIPGA FIALITIDRV
410 420 430 440 450
GRIYPMAMSN LLAGAACLVM IFISPDLHWL NIIIMCVGRM GITIAIQMIC
460 470 480 490 500
LVNAELYPTF VRNLGVMVCS SLCDIGGIIT PFIVFRLREV WQALPLILFA
510 520 530 540 550
VLGLLAAGVT LLLPETKGVA LPETMKDAEN LGRKAKPKEN TIYLKVQTSE

PSGT
Length:554
Mass (Da):61,154
Last modified:November 30, 2010 - v2
Checksum:i55206B897DE32202
GO
Isoform 2 (identifier: O15245-2) [UniParc]FASTAAdd to basket
Also known as: hOCT1G/L506

The sequence of this isoform differs from the canonical sequence as follows:
     462-506: RNLGVMVCSS...ILFAVLGLLA → SGVGPACRGS...SKAQRKHDLP
     507-554: Missing.

Show »
Length:506
Mass (Da):56,094
Checksum:iFDD376F7F8547B5D
GO
Isoform 3 (identifier: O15245-3) [UniParc]FASTAAdd to basket
Also known as: hOCT1G483

The sequence of this isoform differs from the canonical sequence as follows:
     462-532: Missing.

Show »
Length:483
Mass (Da):53,593
Checksum:i843CF89CFB1D9827
GO
Isoform 4 (identifier: O15245-4) [UniParc]FASTAAdd to basket
Also known as: hOCT1G353

The sequence of this isoform differs from the canonical sequence as follows:
     354-554: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:353
Mass (Da):39,224
Checksum:i88073B911A5E5633
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04331914S → F Exclusively found in the African American population; increase of the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant rs34447885dbSNPEnsembl.1
Natural variantiVAR_04332041F → L.1 PublicationCorresponds to variant rs2297373dbSNPEnsembl.1
Natural variantiVAR_04332161R → C Affects transporter activity; reduction of the MPP uptake when associated with V-408. 2 PublicationsCorresponds to variant rs12208357dbSNPEnsembl.1
Natural variantiVAR_04332285L → F No changes in the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant rs35546288dbSNPEnsembl.1
Natural variantiVAR_04332388C → R.1 PublicationCorresponds to variant rs55918055dbSNPEnsembl.1
Natural variantiVAR_043324160L → F No changes in both TEA and MPP uptake; abolishes MPP uptake when associated with S-401; largely localized to the plasma membrane. 7 PublicationsCorresponds to variant rs683369dbSNPEnsembl.1
Natural variantiVAR_043325189S → L No changes in the MPP uptake. 1 PublicationCorresponds to variant rs34104736dbSNPEnsembl.1
Natural variantiVAR_043326220G → V Affects MPP uptake; reduction of the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant rs36103319dbSNPEnsembl.1
Natural variantiVAR_043327283P → L.1 PublicationCorresponds to variant rs4646277dbSNPEnsembl.1
Natural variantiVAR_043328287R → G.1 PublicationCorresponds to variant rs4646278dbSNPEnsembl.1
Natural variantiVAR_043329341P → L Affects transporter activity; reduction of the TEA uptake; reduction of the MPP uptake when associated with V-408; largely localized to the plasma membrane. 3 PublicationsCorresponds to variant rs2282143dbSNPEnsembl.1
Natural variantiVAR_043330342R → H No changes in the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant rs34205214dbSNPEnsembl.1
Natural variantiVAR_043331401G → S Affects transporter activity; reduction of the serotonin uptake; no MPP uptake when associated with L-160. 2 PublicationsCorresponds to variant rs34130495dbSNPEnsembl.1
Natural variantiVAR_043332408M → V Does not affect transporter activity; no changes in the MPP uptake when associated with F-14; no changes in the MPP uptake when associated with F-85; no changes in the MPP uptake when associated with L-189; no changes in the MPP uptake when associated with His-342; no changes in the MPP uptake when associated with M-420 del; no changes in the MPP uptake when associated with I-440; no changes in the MPP uptake when associated with I-461; no changes in the MPP uptake when associated with M-488; reduction of the MPP uptake when associated with C-61; no MPP uptake when associated with V-220; reduction of the MPP uptake when associated with L-341; no MPP uptake when associated with S-401; no MPP uptake when associated with R-465. 3 PublicationsCorresponds to variant rs628031dbSNPEnsembl.1
Natural variantiVAR_043333420Missing No changes in the MPP uptake when associated with V-408. 3 Publications1
Natural variantiVAR_043334440M → I.1 PublicationCorresponds to variant rs35956182dbSNPEnsembl.1
Natural variantiVAR_043335461V → I No changes in the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant rs34295611dbSNPEnsembl.1
Natural variantiVAR_043336465G → R Reduction of the localization to the basolateral membrane; no MPP uptake when associated with V-408. 2 PublicationsCorresponds to variant rs34059508dbSNPEnsembl.1
Natural variantiVAR_043337488R → M No changes in the MPP uptake when associated with V-408. 1 PublicationCorresponds to variant rs35270274dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033587354 – 554Missing in isoform 4. CuratedAdd BLAST201
Alternative sequenceiVSP_033588462 – 532Missing in isoform 3. CuratedAdd BLAST71
Alternative sequenceiVSP_033589462 – 506RNLGV…LGLLA → SGVGPACRGSDATSSRDQGG RFARDHEGRREPWEKSKAQR KHDLP in isoform 2. CuratedAdd BLAST45
Alternative sequenceiVSP_033590507 – 554Missing in isoform 2. CuratedAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98332 mRNA. Translation: CAA66977.1.
U77086 mRNA. Translation: AAB67703.1.
AJ243995
, AJ243996, AJ243998, AJ243999, AJ244000, AJ245460, AJ276051, AJ276052, AJ276053 Genomic DNA. Translation: CAB95971.1.
AK289887 mRNA. Translation: BAF82576.1.
AL353625 Genomic DNA. Translation: CAH72016.1.
BC126364 mRNA. Translation: AAI26365.1.
CCDSiCCDS5274.1. [O15245-1]
CCDS5275.1. [O15245-2]
RefSeqiNP_003048.1. NM_003057.2. [O15245-1]
NP_694857.1. NM_153187.1. [O15245-2]
XP_006715615.1. XM_006715552.1. [O15245-3]
UniGeneiHs.117367.

Genome annotation databases

EnsembliENST00000324965; ENSP00000318103; ENSG00000175003. [O15245-2]
ENST00000366963; ENSP00000355930; ENSG00000175003. [O15245-1]
ENST00000457470; ENSP00000409557; ENSG00000175003. [O15245-3]
ENST00000460902; ENSP00000439274; ENSG00000175003. [O15245-4]
GeneIDi6580.
KEGGihsa:6580.
UCSCiuc003qtc.4. human. [O15245-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98332 mRNA. Translation: CAA66977.1.
U77086 mRNA. Translation: AAB67703.1.
AJ243995
, AJ243996, AJ243998, AJ243999, AJ244000, AJ245460, AJ276051, AJ276052, AJ276053 Genomic DNA. Translation: CAB95971.1.
AK289887 mRNA. Translation: BAF82576.1.
AL353625 Genomic DNA. Translation: CAH72016.1.
BC126364 mRNA. Translation: AAI26365.1.
CCDSiCCDS5274.1. [O15245-1]
CCDS5275.1. [O15245-2]
RefSeqiNP_003048.1. NM_003057.2. [O15245-1]
NP_694857.1. NM_153187.1. [O15245-2]
XP_006715615.1. XM_006715552.1. [O15245-3]
UniGeneiHs.117367.

3D structure databases

ProteinModelPortaliO15245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112467. 1 interactor.
IntActiO15245. 1 interactor.
STRINGi9606.ENSP00000355930.

Chemistry databases

BindingDBiO15245.
ChEMBLiCHEMBL5685.
DrugBankiDB01193. Acebutolol.
DB01614. Acepromazine.
DB03128. Acetylcholine.
DB00787. Aciclovir.
DB00915. Amantadine.
DB00594. Amiloride.
DB00345. Aminohippurate.
DB00520. Caspofungin.
DB01114. Chlorphenamine.
DB00477. Chlorpromazine.
DB00122. Choline.
DB00501. Cimetidine.
DB00242. Cladribine.
DB00575. Clonidine.
DB00318. Codeine.
DB00987. Cytarabine.
DB01151. Desipramine.
DB00917. Dinoprostone.
DB01075. Diphenhydramine.
DB00280. Disopyramide.
DB00988. Dopamine.
DB00668. Epinephrine.
DB00783. Estradiol.
DB04574. Estropipate.
DB01004. Ganciclovir.
DB00406. Gentian Violet.
DB00536. Guanidine.
DB00667. Histamine Phosphate.
DB00619. Imatinib.
DB00458. Imipramine.
DB00224. Indinavir.
DB00709. Lamivudine.
DB00654. Latanoprost.
DB00331. Metformin.
DB00683. Midazolam.
DB00220. Nelfinavir.
DB00184. Nicotine.
DB00368. Norepinephrine.
DB00526. Oxaliplatin.
DB01337. Pancuronium.
DB00914. Phenformin.
DB00925. Phenoxybenzamine.
DB01621. Pipotiazine.
DB00413. Pramipexole.
DB00457. Prazosin.
DB01032. Probenecid.
DB01035. Procainamide.
DB00396. Progesterone.
DB00908. Quinidine.
DB00468. Quinine.
DB00863. Ranitidine.
DB00206. Reserpine.
DB00728. Rocuronium.
DB01232. Saquinavir.
DB00127. Spermine.
DB00624. Testosterone.
DB00152. Thiamine.
DB01622. Thioproperazine.
DB01623. Thiothixene.
DB01199. Tubocurarine.
DB01339. Vecuronium.
DB00661. Verapamil.
GuidetoPHARMACOLOGYi1019.

Protein family/group databases

TCDBi2.A.1.19.29. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiO15245.
PhosphoSitePlusiO15245.

Polymorphism and mutation databases

BioMutaiSLC22A1.

Proteomic databases

PaxDbiO15245.
PeptideAtlasiO15245.
PRIDEiO15245.

Protocols and materials databases

DNASUi6580.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324965; ENSP00000318103; ENSG00000175003. [O15245-2]
ENST00000366963; ENSP00000355930; ENSG00000175003. [O15245-1]
ENST00000457470; ENSP00000409557; ENSG00000175003. [O15245-3]
ENST00000460902; ENSP00000439274; ENSG00000175003. [O15245-4]
GeneIDi6580.
KEGGihsa:6580.
UCSCiuc003qtc.4. human. [O15245-1]

Organism-specific databases

CTDi6580.
DisGeNETi6580.
GeneCardsiSLC22A1.
HGNCiHGNC:10963. SLC22A1.
HPAiHPA029846.
MIMi602607. gene.
neXtProtiNX_O15245.
OpenTargetsiENSG00000175003.
PharmGKBiPA329.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234568.
HOVERGENiHBG061545.
InParanoidiO15245.
KOiK08198.
OMAiDLFQSCL.
OrthoDBiEOG091G05AC.
PhylomeDBiO15245.
TreeFamiTF315847.

Enzyme and pathway databases

ReactomeiR-HSA-112311. Neurotransmitter Clearance In The Synaptic Cleft.
R-HSA-181430. Norepinephrine Neurotransmitter Release Cycle.
R-HSA-2161517. Abacavir transmembrane transport.
R-HSA-442660. Na+/Cl- dependent neurotransmitter transporters.
R-HSA-549127. Organic cation transport.

Miscellaneous databases

GeneWikiiSLC22A1.
GenomeRNAii6580.
PROiO15245.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175003.
CleanExiHS_SLC22A1.
ExpressionAtlasiO15245. baseline and differential.
GenevisibleiO15245. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR004749. Orgcat_transp/SVOP.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22A1_HUMAN
AccessioniPrimary (citable) accession number: O15245
Secondary accession number(s): A6NFF3
, A8K1H2, C9JSU6, O15395, Q9NQD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.