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O15244

- S22A2_HUMAN

UniProt

O15244 - S22A2_HUMAN

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Protein

Solute carrier family 22 member 2

Gene

SLC22A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.14 Publications

Kineticsi

  1. KM=1 mM for agmatine8 Publications
  2. KM=95 µM for amiloride8 Publications
  3. KM=24 µM for ASP8 Publications
  4. KM=34 µM for memantine8 Publications
  5. KM=27 µM for amantadine8 Publications
  6. KM=1.38 mM for metformin8 Publications
  7. KM=1.9 mM for noradrenaline8 Publications
  8. KM=1.9 mM for norepinephrine8 Publications
  9. KM=1.3 mM for histamine8 Publications
  10. KM=0.39 mM for dopamine8 Publications
  11. KM=0.08 mM for serotonine8 Publications
  12. KM=72.6 µM for cimetidine (at pH 7.4 and 37 degrees Celsius)8 Publications
  13. KM=56.1 µM for famotidine8 Publications
  14. KM=65.2 µM for ranitidine8 Publications
  15. KM=431 µM for TEA (isoform 1)8 Publications
  16. KM=63 µM for TEA (isoform 2)8 Publications

Vmax=3770 pmol/min/mg enzyme for TEA uptake (isoform 1)8 Publications

Vmax=314 pmol/min/mg enzyme for TEA uptake (isoform 2)8 Publications

Vmax=11.9 nmol/min/mg enzyme for metformin uptake8 Publications

Vmax=2170 pmol/min/mg enzyme for cimetidine uptake8 Publications

Vmax=204 pmol/min/mg enzyme for famotidine uptake8 Publications

Vmax=265 pmol/min/mg enzyme for ranitidine uptake8 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei451 – 4511Involved in recognition of organic cations and participates in structural changes that occur during translocation of organic cationsBy similarity

GO - Molecular functioni

  1. choline transmembrane transporter activity Source: Ensembl
  2. organic cation transmembrane transporter activity Source: MGI
  3. quaternary ammonium group transmembrane transporter activity Source: Ensembl
  4. steroid binding Source: Ensembl

GO - Biological processi

  1. body fluid secretion Source: ProtInc
  2. drug transmembrane transport Source: Reactome
  3. histamine transport Source: Ensembl
  4. neurotransmitter biosynthetic process Source: Reactome
  5. neurotransmitter secretion Source: Reactome
  6. organic cation transport Source: MGI
  7. small molecule metabolic process Source: Reactome
  8. synaptic transmission Source: Reactome
  9. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_120801. Abacavir transmembrane transport.
REACT_13583. Neurotransmitter Clearance In The Synaptic Cleft.
REACT_15418. Norepinephrine Neurotransmitter Release Cycle.
REACT_20506. Na+/Cl- dependent neurotransmitter transporters.
REACT_22357. Organic cation transport.

Protein family/group databases

TCDBi2.A.1.19.30. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 2
Alternative name(s):
Organic cation transporter 2
Short name:
hOCT2
Gene namesi
Name:SLC22A2
Synonyms:OCT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:10966. SLC22A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei23 – 4321HelicalSequence AnalysisAdd
BLAST
Topological domaini44 – 150107ExtracellularSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Topological domaini172 – 1776CytoplasmicSequence Analysis
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST
Topological domaini199 – 20810ExtracellularSequence Analysis
Transmembranei209 – 22921HelicalSequence AnalysisAdd
BLAST
Topological domaini230 – 2389CytoplasmicSequence Analysis
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST
Topological domaini260 – 2634ExtracellularSequence Analysis
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Topological domaini285 – 34864CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei349 – 36921HelicalSequence AnalysisAdd
BLAST
Topological domaini370 – 3756ExtracellularSequence Analysis
Transmembranei376 – 39621HelicalSequence AnalysisAdd
BLAST
Topological domaini397 – 41418CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei415 – 43521HelicalSequence AnalysisAdd
BLAST
Topological domaini436 – 4416ExtracellularSequence Analysis
Transmembranei442 – 46221HelicalSequence AnalysisAdd
BLAST
Topological domaini463 – 4642CytoplasmicSequence Analysis
Transmembranei465 – 48521HelicalSequence AnalysisAdd
BLAST
Topological domaini486 – 4949ExtracellularSequence Analysis
Transmembranei495 – 51521HelicalSequence AnalysisAdd
BLAST
Topological domaini516 – 55540CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of plasma membrane Source: ProtInc
  4. membrane Source: ProtInc
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA331.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Solute carrier family 22 member 2PRO_0000320957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO15244.
PRIDEiO15244.

PTM databases

PhosphoSiteiO15244.

Expressioni

Tissue specificityi

Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma.4 Publications

Inductioni

May be down-regulated in diabetic patients.1 Publication

Gene expression databases

BgeeiO15244.
CleanExiHS_SLC22A2.
ExpressionAtlasiO15244. baseline and differential.
GenevestigatoriO15244.

Organism-specific databases

HPAiHPA008567.

Interactioni

Protein-protein interaction databases

BioGridi112469. 8 interactions.
IntActiO15244. 8 interactions.
STRINGi9606.ENSP00000355920.

Structurei

3D structure databases

ProteinModelPortaliO15244.
SMRiO15244. Positions 144-524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234568.
HOVERGENiHBG061545.
InParanoidiO15244.
KOiK08199.
OMAiEDAENMH.
OrthoDBiEOG78PV8N.
PhylomeDBiO15244.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O15244-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPTTVDDVLE HGGEFHFFQK QMFFLLALLS ATFAPIYVGI VFLGFTPDHR
60 70 80 90 100
CRSPGVAELS LRCGWSPAEE LNYTVPGPGP AGEASPRQCR RYEVDWNQST
110 120 130 140 150
FDCVDPLASL DTNRSRLPLG PCRDGWVYET PGSSIVTEFN LVCANSWMLD
160 170 180 190 200
LFQSSVNVGF FIGSMSIGYI ADRFGRKLCL LTTVLINAAA GVLMAISPTY
210 220 230 240 250
TWMLIFRLIQ GLVSKAGWLI GYILITEFVG RRYRRTVGIF YQVAYTVGLL
260 270 280 290 300
VLAGVAYALP HWRWLQFTVS LPNFFFLLYY WCIPESPRWL ISQNKNAEAM
310 320 330 340 350
RIIKHIAKKN GKSLPASLQR LRLEEETGKK LNPSFLDLVR TPQIRKHTMI
360 370 380 390 400
LMYNWFTSSV LYQGLIMHMG LAGDNIYLDF FYSALVEFPA AFMIILTIDR
410 420 430 440 450
IGRRYPWAAS NMVAGAACLA SVFIPGDLQW LKIIISCLGR MGITMAYEIV
460 470 480 490 500
CLVNAELYPT FIRNLGVHIC SSMCDIGGII TPFLVYRLTN IWLELPLMVF
510 520 530 540 550
GVLGLVAGGL VLLLPETKGK ALPETIEEAE NMQRPRKNKE KMIYLQVQKL

DIPLN
Length:555
Mass (Da):62,581
Last modified:November 30, 2010 - v2
Checksum:i06528F9519CE211E
GO
Isoform 2 (identifier: O15244-2) [UniParc]FASTAAdd to Basket

Also known as: OCT2-A

The sequence of this isoform differs from the canonical sequence as follows:
     427-483: DLQWLKIIIS...CDIGGIITPF → GKFQVKLESY...SEQIHMASLL
     484-555: Missing.

Show »
Length:483
Mass (Da):54,475
Checksum:i0AD53D9697B4E7B2
GO
Isoform 3 (identifier: O15244-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-242: ITEFVGRRYRRTVGIFYQ → SKNVCACNCENKATSLPK
     243-555: Missing.

Note: No experimental confirmation available.

Show »
Length:242
Mass (Da):26,685
Checksum:i510EAB0C05C06B43
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541P → S.1 Publication
Corresponds to variant rs8177504 [ dbSNP | Ensembl ].
VAR_039322
Natural varianti165 – 1651M → I Lower Vmax.
Corresponds to variant rs8177507 [ dbSNP | Ensembl ].
VAR_039323
Natural varianti201 – 2011T → M.1 Publication
Corresponds to variant rs145450955 [ dbSNP | Ensembl ].
VAR_039324
Natural varianti270 – 2701S → A Increased Ki value for TBA inhibition of MPP. 5 Publications
Corresponds to variant rs316019 [ dbSNP | Ensembl ].
VAR_039325
Natural varianti297 – 2971A → G.
Corresponds to variant rs8177513 [ dbSNP | Ensembl ].
VAR_039326
Natural varianti400 – 4001R → C Lower Vmax and reduced Ki value for TBA inhibition of MPP.
Corresponds to variant rs8177516 [ dbSNP | Ensembl ].
VAR_039327
Natural varianti432 – 4321K → Q Lower Km value for MPP and reduced Ki value for TBA inhibition of MPP.
Corresponds to variant rs8177517 [ dbSNP | Ensembl ].
VAR_039328
Natural varianti463 – 4631R → K.
Corresponds to variant rs3907239 [ dbSNP | Ensembl ].
VAR_039329

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei225 – 24218ITEFV…GIFYQ → SKNVCACNCENKATSLPK in isoform 3. 1 PublicationVSP_031771Add
BLAST
Alternative sequencei243 – 555313Missing in isoform 3. 1 PublicationVSP_031772Add
BLAST
Alternative sequencei427 – 48357DLQWL…IITPF → GKFQVKLESYLQDPGERECH GPLIGKPCNLSSKSIWKDKL EGSIWDPSEQIHMASLL in isoform 2. 1 PublicationVSP_031773Add
BLAST
Alternative sequencei484 – 55572Missing in isoform 2. 1 PublicationVSP_031774Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98333 mRNA. Translation: CAA66978.1.
AB075951 mRNA. Translation: BAC02720.1.
AK290787 mRNA. Translation: BAF83476.1.
AL162582 Genomic DNA. Translation: CAI20003.1.
CH471051 Genomic DNA. Translation: EAW47602.1.
BC030978 mRNA. Translation: AAH30978.1.
BC039899 mRNA. Translation: AAH39899.1.
AJ251885 Genomic DNA. Translation: CAB96133.1.
CCDSiCCDS5276.1. [O15244-1]
RefSeqiNP_003049.2. NM_003058.3. [O15244-1]
UniGeneiHs.436385.

Genome annotation databases

EnsembliENST00000366953; ENSP00000355920; ENSG00000112499. [O15244-1]
GeneIDi6582.
KEGGihsa:6582.
UCSCiuc003qtf.3. human. [O15244-1]
uc003qth.2. human. [O15244-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98333 mRNA. Translation: CAA66978.1 .
AB075951 mRNA. Translation: BAC02720.1 .
AK290787 mRNA. Translation: BAF83476.1 .
AL162582 Genomic DNA. Translation: CAI20003.1 .
CH471051 Genomic DNA. Translation: EAW47602.1 .
BC030978 mRNA. Translation: AAH30978.1 .
BC039899 mRNA. Translation: AAH39899.1 .
AJ251885 Genomic DNA. Translation: CAB96133.1 .
CCDSi CCDS5276.1. [O15244-1 ]
RefSeqi NP_003049.2. NM_003058.3. [O15244-1 ]
UniGenei Hs.436385.

3D structure databases

ProteinModelPortali O15244.
SMRi O15244. Positions 144-524.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112469. 8 interactions.
IntActi O15244. 8 interactions.
STRINGi 9606.ENSP00000355920.

Chemistry

BindingDBi O15244.
ChEMBLi CHEMBL1743122.
DrugBanki DB00915. Amantadine.
DB00594. Amiloride.
DB00345. Aminohippurate.
DB01114. Chlorphenamine.
DB00122. Choline.
DB00501. Cimetidine.
DB00515. Cisplatin.
DB00242. Cladribine.
DB00907. Cocaine.
DB00987. Cytarabine.
DB00694. Daunorubicin.
DB01151. Desipramine.
DB01160. Dinoprost Tromethamine.
DB00917. Dinoprostone.
DB01075. Diphenhydramine.
DB00280. Disopyramide.
DB00988. Dopamine.
DB00668. Epinephrine.
DB00783. Estradiol.
DB00927. Famotidine.
DB00690. Flurazepam.
DB00536. Guanidine.
DB00667. Histamine Phosphate.
DB00619. Imatinib.
DB00458. Imipramine.
DB00709. Lamivudine.
DB01137. Levofloxacin.
DB01043. Memantine.
DB00331. Metformin.
DB00264. Metoprolol.
DB00184. Nicotine.
DB00368. Norepinephrine.
DB00526. Oxaliplatin.
DB01580. Oxprenolol.
DB01337. Pancuronium.
DB00914. Phenformin.
DB00925. Phenoxybenzamine.
DB00413. Pramipexole.
DB00457. Prazosin.
DB01032. Probenecid.
DB01035. Procainamide.
DB00396. Progesterone.
DB00571. Propranolol.
DB01103. Quinacrine.
DB00908. Quinidine.
DB00468. Quinine.
DB00206. Reserpine.
DB00152. Thiamine.
DB01199. Tubocurarine.
DB00570. Vinblastine.
DB00495. Zidovudine.

Protein family/group databases

TCDBi 2.A.1.19.30. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei O15244.

Proteomic databases

PaxDbi O15244.
PRIDEi O15244.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366953 ; ENSP00000355920 ; ENSG00000112499 . [O15244-1 ]
GeneIDi 6582.
KEGGi hsa:6582.
UCSCi uc003qtf.3. human. [O15244-1 ]
uc003qth.2. human. [O15244-3 ]

Organism-specific databases

CTDi 6582.
GeneCardsi GC06M160592.
H-InvDB HIX0025014.
HGNCi HGNC:10966. SLC22A2.
HPAi HPA008567.
MIMi 602608. gene.
neXtProti NX_O15244.
PharmGKBi PA331.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00760000118852.
HOGENOMi HOG000234568.
HOVERGENi HBG061545.
InParanoidi O15244.
KOi K08199.
OMAi EDAENMH.
OrthoDBi EOG78PV8N.
PhylomeDBi O15244.
TreeFami TF315847.

Enzyme and pathway databases

Reactomei REACT_120801. Abacavir transmembrane transport.
REACT_13583. Neurotransmitter Clearance In The Synaptic Cleft.
REACT_15418. Norepinephrine Neurotransmitter Release Cycle.
REACT_20506. Na+/Cl- dependent neurotransmitter transporters.
REACT_22357. Organic cation transport.

Miscellaneous databases

GeneWikii SLC22A2.
GenomeRNAii 6582.
NextBioi 25613.
PROi O15244.
SOURCEi Search...

Gene expression databases

Bgeei O15244.
CleanExi HS_SLC22A2.
ExpressionAtlasi O15244. baseline and differential.
Genevestigatori O15244.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00898. 2A0119. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, VARIANT ALA-270.
    Tissue: Kidney cortex.
  2. "cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney."
    Urakami Y., Akazawa M., Saito H., Okuda M., Inui K.
    J. Am. Soc. Nephrol. 13:1703-1710(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, VARIANT ALA-270.
    Tissue: Kidney.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-270.
    Tissue: Kidney.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ALA-270.
    Tissue: Colon and Kidney.
  7. "Gene structures of the human non-neuronal monoamine transporters EMT and OCT2."
    Gruendemann D., Schoemig E.
    Hum. Genet. 106:627-635(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-138.
  8. "Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine."
    Busch A.E., Karbach U., Miska D., Gorboulev V., Akhoundova A., Volk C., Arndt P., Ulzheimer J.C., Sonders M.S., Baumann C., Waldegger S., Lang F., Koepsell H.
    Mol. Pharmacol. 54:342-352(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
  9. "Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules."
    Urakami Y., Okuda M., Masuda S., Akazawa M., Saito H., Inui K.
    Pharm. Res. 18:1528-1534(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: BIOPHYSICOCHEMICAL PROPERTIES.
  10. "Gene expression levels and immunolocalization of organic ion transporters in the human kidney."
    Motohashi H., Sakurai Y., Saito H., Masuda S., Urakami Y., Goto M., Fukatsu A., Ogawa O., Inui K.
    J. Am. Soc. Nephrol. 13:866-874(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. "Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2)."
    Grundemann D., Hahne C., Berkels R., Schomig E.
    J. Pharmacol. Exp. Ther. 304:810-817(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
  12. "Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A)."
    Motohashi H., Uwai Y., Hiramoto K., Okuda M., Inui K.
    Eur. J. Pharmacol. 503:25-30(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2."
    Ciarimboli G., Ludwig T., Lang D., Pavenstaedt H., Koepsell H., Piechota H.J., Haier J., Jaehde U., Zisowsky J., Schlatter E.
    Am. J. Pathol. 167:1477-1484(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  14. "Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1."
    Kimura N., Masuda S., Tanihara Y., Ueo H., Okuda M., Katsura T., Inui K.
    Drug Metab. Pharmacokinet. 20:379-386(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
  15. "A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters."
    Tahara H., Kusuhara H., Endou H., Koepsell H., Imaoka T., Fuse E., Sugiyama Y.
    J. Pharmacol. Exp. Ther. 315:337-345(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
  16. "Metformin transport by renal basolateral organic cation transporter hOCT2."
    Kimura N., Okuda M., Inui K.
    Pharm. Res. 22:255-259(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
  17. "Characterization of regulatory mechanisms and states of human organic cation transporter 2."
    Biermann J., Lang D., Gorboulev V., Koepsell H., Sindic A., Schroter R., Zvirbliene A., Pavenstadt H., Schlatter E., Ciarimboli G.
    Am. J. Physiol. 290:C1521-C1531(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
  18. Cited for: FUNCTION.
  19. "Interactions of fluoroquinolone antibacterials, DX-619 and levofloxacin, with creatinine transport by renal organic cation transporter hOCT2."
    Okuda M., Kimura N., Inui K.
    Drug Metab. Pharmacokinet. 21:432-436(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  20. "Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family)."
    Yonezawa A., Masuda S., Yokoo S., Katsura T., Inui K.
    J. Pharmacol. Exp. Ther. 319:879-886(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  21. "Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity."
    Yokoo S., Yonezawa A., Masuda S., Fukatsu A., Katsura T., Inui K.
    Biochem. Pharmacol. 74:477-487(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  22. "The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua."
    Bottalico B., Noskova V., Pilka R., Larsson I., Domanski H., Casslen B., Hansson S.R.
    Mol. Reprod. Dev. 74:1303-1311(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  23. "Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function."
    Leabman M.K., Huang C.C., Kawamoto M., Johns S.J., Stryke D., Ferrin T.E., DeYoung J., Taylor T., Clark A.G., Herskowitz I., Giacomini K.M.
    Pharmacogenetics 12:395-405(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SER-54, CHARACTERIZATION OF VARIANTS ILE-165; ALA-270; CYS-400 AND GLN-432.
  24. "Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin."
    Shikata E., Yamamoto R., Takane H., Shigemasa C., Ikeda T., Otsubo K., Ieiri I.
    J. Hum. Genet. 52:117-122(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS MET-201 AND ALA-270.

Entry informationi

Entry nameiS22A2_HUMAN
AccessioniPrimary (citable) accession number: O15244
Secondary accession number(s): Q5T7Q6
, Q6PIQ8, Q8NG62, Q9NQB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 30, 2010
Last modified: November 26, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3