Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O15244

- S22A2_HUMAN

UniProt

O15244 - S22A2_HUMAN

Protein

Solute carrier family 22 member 2

Gene

SLC22A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.14 Publications

    Kineticsi

    1. KM=1 mM for agmatine8 Publications
    2. KM=95 µM for amiloride8 Publications
    3. KM=24 µM for ASP8 Publications
    4. KM=34 µM for memantine8 Publications
    5. KM=27 µM for amantadine8 Publications
    6. KM=1.38 mM for metformin8 Publications
    7. KM=1.9 mM for noradrenaline8 Publications
    8. KM=1.9 mM for norepinephrine8 Publications
    9. KM=1.3 mM for histamine8 Publications
    10. KM=0.39 mM for dopamine8 Publications
    11. KM=0.08 mM for serotonine8 Publications
    12. KM=72.6 µM for cimetidine (at pH 7.4 and 37 degrees Celsius)8 Publications
    13. KM=56.1 µM for famotidine8 Publications
    14. KM=65.2 µM for ranitidine8 Publications
    15. KM=431 µM for TEA (isoform 1)8 Publications
    16. KM=63 µM for TEA (isoform 2)8 Publications

    Vmax=3770 pmol/min/mg enzyme for TEA uptake (isoform 1)8 Publications

    Vmax=314 pmol/min/mg enzyme for TEA uptake (isoform 2)8 Publications

    Vmax=11.9 nmol/min/mg enzyme for metformin uptake8 Publications

    Vmax=2170 pmol/min/mg enzyme for cimetidine uptake8 Publications

    Vmax=204 pmol/min/mg enzyme for famotidine uptake8 Publications

    Vmax=265 pmol/min/mg enzyme for ranitidine uptake8 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei451 – 4511Involved in recognition of organic cations and participates in structural changes that occur during translocation of organic cationsBy similarity

    GO - Molecular functioni

    1. choline transmembrane transporter activity Source: Ensembl
    2. organic cation transmembrane transporter activity Source: MGI
    3. quaternary ammonium group transmembrane transporter activity Source: Ensembl
    4. steroid binding Source: Ensembl

    GO - Biological processi

    1. body fluid secretion Source: ProtInc
    2. drug transmembrane transport Source: Reactome
    3. histamine transport Source: Ensembl
    4. neurotransmitter biosynthetic process Source: Reactome
    5. neurotransmitter secretion Source: Reactome
    6. organic cation transport Source: MGI
    7. small molecule metabolic process Source: Reactome
    8. synaptic transmission Source: Reactome
    9. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_120801. Abacavir transmembrane transport.
    REACT_13583. Neurotransmitter Clearance In The Synaptic Cleft.
    REACT_15418. Norepinephrine Neurotransmitter Release Cycle.
    REACT_20506. Na+/Cl- dependent neurotransmitter transporters.
    REACT_22357. Organic cation transport.

    Protein family/group databases

    TCDBi2.A.1.19.30. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 2
    Alternative name(s):
    Organic cation transporter 2
    Short name:
    hOCT2
    Gene namesi
    Name:SLC22A2
    Synonyms:OCT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:10966. SLC22A2.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of plasma membrane Source: ProtInc
    4. membrane Source: ProtInc
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA331.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Solute carrier family 22 member 2PRO_0000320957Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO15244.
    PRIDEiO15244.

    PTM databases

    PhosphoSiteiO15244.

    Expressioni

    Tissue specificityi

    Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma.4 Publications

    Inductioni

    May be down-regulated in diabetic patients.1 Publication

    Gene expression databases

    ArrayExpressiO15244.
    BgeeiO15244.
    CleanExiHS_SLC22A2.
    GenevestigatoriO15244.

    Organism-specific databases

    HPAiHPA008567.

    Interactioni

    Protein-protein interaction databases

    BioGridi112469. 8 interactions.
    IntActiO15244. 8 interactions.
    STRINGi9606.ENSP00000355920.

    Structurei

    3D structure databases

    ProteinModelPortaliO15244.
    SMRiO15244. Positions 144-524.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini44 – 150107ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini172 – 1776CytoplasmicSequence Analysis
    Topological domaini199 – 20810ExtracellularSequence Analysis
    Topological domaini230 – 2389CytoplasmicSequence Analysis
    Topological domaini260 – 2634ExtracellularSequence Analysis
    Topological domaini285 – 34864CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini370 – 3756ExtracellularSequence Analysis
    Topological domaini397 – 41418CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini436 – 4416ExtracellularSequence Analysis
    Topological domaini463 – 4642CytoplasmicSequence Analysis
    Topological domaini486 – 4949ExtracellularSequence Analysis
    Topological domaini516 – 55540CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei349 – 36921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei376 – 39621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei415 – 43521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei442 – 46221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei465 – 48521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei495 – 51521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000234568.
    HOVERGENiHBG061545.
    InParanoidiO15244.
    KOiK08199.
    OMAiEDAENMH.
    OrthoDBiEOG78PV8N.
    PhylomeDBiO15244.
    TreeFamiTF315847.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004749. Orgcat_transp.
    IPR005828. Sub_transporter.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00898. 2A0119. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O15244-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPTTVDDVLE HGGEFHFFQK QMFFLLALLS ATFAPIYVGI VFLGFTPDHR    50
    CRSPGVAELS LRCGWSPAEE LNYTVPGPGP AGEASPRQCR RYEVDWNQST 100
    FDCVDPLASL DTNRSRLPLG PCRDGWVYET PGSSIVTEFN LVCANSWMLD 150
    LFQSSVNVGF FIGSMSIGYI ADRFGRKLCL LTTVLINAAA GVLMAISPTY 200
    TWMLIFRLIQ GLVSKAGWLI GYILITEFVG RRYRRTVGIF YQVAYTVGLL 250
    VLAGVAYALP HWRWLQFTVS LPNFFFLLYY WCIPESPRWL ISQNKNAEAM 300
    RIIKHIAKKN GKSLPASLQR LRLEEETGKK LNPSFLDLVR TPQIRKHTMI 350
    LMYNWFTSSV LYQGLIMHMG LAGDNIYLDF FYSALVEFPA AFMIILTIDR 400
    IGRRYPWAAS NMVAGAACLA SVFIPGDLQW LKIIISCLGR MGITMAYEIV 450
    CLVNAELYPT FIRNLGVHIC SSMCDIGGII TPFLVYRLTN IWLELPLMVF 500
    GVLGLVAGGL VLLLPETKGK ALPETIEEAE NMQRPRKNKE KMIYLQVQKL 550
    DIPLN 555
    Length:555
    Mass (Da):62,581
    Last modified:November 30, 2010 - v2
    Checksum:i06528F9519CE211E
    GO
    Isoform 2 (identifier: O15244-2) [UniParc]FASTAAdd to Basket

    Also known as: OCT2-A

    The sequence of this isoform differs from the canonical sequence as follows:
         427-483: DLQWLKIIIS...CDIGGIITPF → GKFQVKLESY...SEQIHMASLL
         484-555: Missing.

    Show »
    Length:483
    Mass (Da):54,475
    Checksum:i0AD53D9697B4E7B2
    GO
    Isoform 3 (identifier: O15244-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         225-242: ITEFVGRRYRRTVGIFYQ → SKNVCACNCENKATSLPK
         243-555: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:242
    Mass (Da):26,685
    Checksum:i510EAB0C05C06B43
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti54 – 541P → S.1 Publication
    Corresponds to variant rs8177504 [ dbSNP | Ensembl ].
    VAR_039322
    Natural varianti165 – 1651M → I Lower Vmax.
    Corresponds to variant rs8177507 [ dbSNP | Ensembl ].
    VAR_039323
    Natural varianti201 – 2011T → M.1 Publication
    Corresponds to variant rs145450955 [ dbSNP | Ensembl ].
    VAR_039324
    Natural varianti270 – 2701S → A Increased Ki value for TBA inhibition of MPP. 5 Publications
    Corresponds to variant rs316019 [ dbSNP | Ensembl ].
    VAR_039325
    Natural varianti297 – 2971A → G.
    Corresponds to variant rs8177513 [ dbSNP | Ensembl ].
    VAR_039326
    Natural varianti400 – 4001R → C Lower Vmax and reduced Ki value for TBA inhibition of MPP.
    Corresponds to variant rs8177516 [ dbSNP | Ensembl ].
    VAR_039327
    Natural varianti432 – 4321K → Q Lower Km value for MPP and reduced Ki value for TBA inhibition of MPP.
    Corresponds to variant rs8177517 [ dbSNP | Ensembl ].
    VAR_039328
    Natural varianti463 – 4631R → K.
    Corresponds to variant rs3907239 [ dbSNP | Ensembl ].
    VAR_039329

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei225 – 24218ITEFV…GIFYQ → SKNVCACNCENKATSLPK in isoform 3. 1 PublicationVSP_031771Add
    BLAST
    Alternative sequencei243 – 555313Missing in isoform 3. 1 PublicationVSP_031772Add
    BLAST
    Alternative sequencei427 – 48357DLQWL…IITPF → GKFQVKLESYLQDPGERECH GPLIGKPCNLSSKSIWKDKL EGSIWDPSEQIHMASLL in isoform 2. 1 PublicationVSP_031773Add
    BLAST
    Alternative sequencei484 – 55572Missing in isoform 2. 1 PublicationVSP_031774Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X98333 mRNA. Translation: CAA66978.1.
    AB075951 mRNA. Translation: BAC02720.1.
    AK290787 mRNA. Translation: BAF83476.1.
    AL162582 Genomic DNA. Translation: CAI20003.1.
    CH471051 Genomic DNA. Translation: EAW47602.1.
    BC030978 mRNA. Translation: AAH30978.1.
    BC039899 mRNA. Translation: AAH39899.1.
    AJ251885 Genomic DNA. Translation: CAB96133.1.
    CCDSiCCDS5276.1. [O15244-1]
    RefSeqiNP_003049.2. NM_003058.3. [O15244-1]
    UniGeneiHs.436385.

    Genome annotation databases

    EnsembliENST00000366953; ENSP00000355920; ENSG00000112499. [O15244-1]
    GeneIDi6582.
    KEGGihsa:6582.
    UCSCiuc003qtf.3. human. [O15244-1]
    uc003qth.2. human. [O15244-3]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X98333 mRNA. Translation: CAA66978.1 .
    AB075951 mRNA. Translation: BAC02720.1 .
    AK290787 mRNA. Translation: BAF83476.1 .
    AL162582 Genomic DNA. Translation: CAI20003.1 .
    CH471051 Genomic DNA. Translation: EAW47602.1 .
    BC030978 mRNA. Translation: AAH30978.1 .
    BC039899 mRNA. Translation: AAH39899.1 .
    AJ251885 Genomic DNA. Translation: CAB96133.1 .
    CCDSi CCDS5276.1. [O15244-1 ]
    RefSeqi NP_003049.2. NM_003058.3. [O15244-1 ]
    UniGenei Hs.436385.

    3D structure databases

    ProteinModelPortali O15244.
    SMRi O15244. Positions 144-524.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112469. 8 interactions.
    IntActi O15244. 8 interactions.
    STRINGi 9606.ENSP00000355920.

    Chemistry

    ChEMBLi CHEMBL1743122.

    Protein family/group databases

    TCDBi 2.A.1.19.30. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei O15244.

    Proteomic databases

    PaxDbi O15244.
    PRIDEi O15244.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366953 ; ENSP00000355920 ; ENSG00000112499 . [O15244-1 ]
    GeneIDi 6582.
    KEGGi hsa:6582.
    UCSCi uc003qtf.3. human. [O15244-1 ]
    uc003qth.2. human. [O15244-3 ]

    Organism-specific databases

    CTDi 6582.
    GeneCardsi GC06M160592.
    H-InvDB HIX0025014.
    HGNCi HGNC:10966. SLC22A2.
    HPAi HPA008567.
    MIMi 602608. gene.
    neXtProti NX_O15244.
    PharmGKBi PA331.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000234568.
    HOVERGENi HBG061545.
    InParanoidi O15244.
    KOi K08199.
    OMAi EDAENMH.
    OrthoDBi EOG78PV8N.
    PhylomeDBi O15244.
    TreeFami TF315847.

    Enzyme and pathway databases

    Reactomei REACT_120801. Abacavir transmembrane transport.
    REACT_13583. Neurotransmitter Clearance In The Synaptic Cleft.
    REACT_15418. Norepinephrine Neurotransmitter Release Cycle.
    REACT_20506. Na+/Cl- dependent neurotransmitter transporters.
    REACT_22357. Organic cation transport.

    Miscellaneous databases

    GeneWikii SLC22A2.
    GenomeRNAii 6582.
    NextBioi 25613.
    PROi O15244.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15244.
    Bgeei O15244.
    CleanExi HS_SLC22A2.
    Genevestigatori O15244.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004749. Orgcat_transp.
    IPR005828. Sub_transporter.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    TIGRFAMsi TIGR00898. 2A0119. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, VARIANT ALA-270.
      Tissue: Kidney cortex.
    2. "cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney."
      Urakami Y., Akazawa M., Saito H., Okuda M., Inui K.
      J. Am. Soc. Nephrol. 13:1703-1710(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, VARIANT ALA-270.
      Tissue: Kidney.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-270.
      Tissue: Kidney.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ALA-270.
      Tissue: Colon and Kidney.
    7. "Gene structures of the human non-neuronal monoamine transporters EMT and OCT2."
      Gruendemann D., Schoemig E.
      Hum. Genet. 106:627-635(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-138.
    8. "Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine."
      Busch A.E., Karbach U., Miska D., Gorboulev V., Akhoundova A., Volk C., Arndt P., Ulzheimer J.C., Sonders M.S., Baumann C., Waldegger S., Lang F., Koepsell H.
      Mol. Pharmacol. 54:342-352(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
    9. "Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules."
      Urakami Y., Okuda M., Masuda S., Akazawa M., Saito H., Inui K.
      Pharm. Res. 18:1528-1534(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: BIOPHYSICOCHEMICAL PROPERTIES.
    10. "Gene expression levels and immunolocalization of organic ion transporters in the human kidney."
      Motohashi H., Sakurai Y., Saito H., Masuda S., Urakami Y., Goto M., Fukatsu A., Ogawa O., Inui K.
      J. Am. Soc. Nephrol. 13:866-874(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2)."
      Grundemann D., Hahne C., Berkels R., Schomig E.
      J. Pharmacol. Exp. Ther. 304:810-817(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
    12. "Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A)."
      Motohashi H., Uwai Y., Hiramoto K., Okuda M., Inui K.
      Eur. J. Pharmacol. 503:25-30(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2."
      Ciarimboli G., Ludwig T., Lang D., Pavenstaedt H., Koepsell H., Piechota H.J., Haier J., Jaehde U., Zisowsky J., Schlatter E.
      Am. J. Pathol. 167:1477-1484(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    14. "Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1."
      Kimura N., Masuda S., Tanihara Y., Ueo H., Okuda M., Katsura T., Inui K.
      Drug Metab. Pharmacokinet. 20:379-386(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
    15. "A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters."
      Tahara H., Kusuhara H., Endou H., Koepsell H., Imaoka T., Fuse E., Sugiyama Y.
      J. Pharmacol. Exp. Ther. 315:337-345(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
    16. "Metformin transport by renal basolateral organic cation transporter hOCT2."
      Kimura N., Okuda M., Inui K.
      Pharm. Res. 22:255-259(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
    17. "Characterization of regulatory mechanisms and states of human organic cation transporter 2."
      Biermann J., Lang D., Gorboulev V., Koepsell H., Sindic A., Schroter R., Zvirbliene A., Pavenstadt H., Schlatter E., Ciarimboli G.
      Am. J. Physiol. 290:C1521-C1531(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
    18. Cited for: FUNCTION.
    19. "Interactions of fluoroquinolone antibacterials, DX-619 and levofloxacin, with creatinine transport by renal organic cation transporter hOCT2."
      Okuda M., Kimura N., Inui K.
      Drug Metab. Pharmacokinet. 21:432-436(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    20. "Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family)."
      Yonezawa A., Masuda S., Yokoo S., Katsura T., Inui K.
      J. Pharmacol. Exp. Ther. 319:879-886(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    21. "Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity."
      Yokoo S., Yonezawa A., Masuda S., Fukatsu A., Katsura T., Inui K.
      Biochem. Pharmacol. 74:477-487(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    22. "The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua."
      Bottalico B., Noskova V., Pilka R., Larsson I., Domanski H., Casslen B., Hansson S.R.
      Mol. Reprod. Dev. 74:1303-1311(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    23. "Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function."
      Leabman M.K., Huang C.C., Kawamoto M., Johns S.J., Stryke D., Ferrin T.E., DeYoung J., Taylor T., Clark A.G., Herskowitz I., Giacomini K.M.
      Pharmacogenetics 12:395-405(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SER-54, CHARACTERIZATION OF VARIANTS ILE-165; ALA-270; CYS-400 AND GLN-432.
    24. "Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin."
      Shikata E., Yamamoto R., Takane H., Shigemasa C., Ikeda T., Otsubo K., Ieiri I.
      J. Hum. Genet. 52:117-122(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS MET-201 AND ALA-270.

    Entry informationi

    Entry nameiS22A2_HUMAN
    AccessioniPrimary (citable) accession number: O15244
    Secondary accession number(s): Q5T7Q6
    , Q6PIQ8, Q8NG62, Q9NQB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3