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O15244 (S22A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 22 member 2
Alternative name(s):
Organic cation transporter 2
Short name=hOCT2
Gene names
Name:SLC22A2
Synonyms:OCT2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. Ref.1 Ref.2 Ref.8 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma. Ref.1 Ref.8 Ref.10 Ref.22

Induction

May be down-regulated in diabetic patients. Ref.13

Sequence similarities

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]

Biophysicochemical properties

Kinetic parameters:

KM=1 mM for agmatine Ref.2 Ref.8 Ref.9 Ref.11 Ref.14 Ref.15 Ref.16 Ref.17

KM=95 µM for amiloride

KM=24 µM for ASP

KM=34 µM for memantine

KM=27 µM for amantadine

KM=1.38 mM for metformin

KM=1.9 mM for noradrenaline

KM=1.9 mM for norepinephrine

KM=1.3 mM for histamine

KM=0.39 mM for dopamine

KM=0.08 mM for serotonine

KM=72.6 µM for cimetidine (at pH 7.4 and 37 degrees Celsius)

KM=56.1 µM for famotidine

KM=65.2 µM for ranitidine

KM=431 µM for TEA (isoform 1)

KM=63 µM for TEA (isoform 2)

Vmax=3770 pmol/min/mg enzyme for TEA uptake (isoform 1)

Vmax=314 pmol/min/mg enzyme for TEA uptake (isoform 2)

Vmax=11.9 nmol/min/mg enzyme for metformin uptake

Vmax=2170 pmol/min/mg enzyme for cimetidine uptake

Vmax=204 pmol/min/mg enzyme for famotidine uptake

Vmax=265 pmol/min/mg enzyme for ranitidine uptake

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbody fluid secretion

Traceable author statement Ref.1. Source: ProtInc

drug transmembrane transport

Traceable author statement. Source: Reactome

histamine transport

Inferred from electronic annotation. Source: Ensembl

neurotransmitter biosynthetic process

Traceable author statement. Source: Reactome

neurotransmitter secretion

Traceable author statement. Source: Reactome

organic cation transport

Inferred from direct assay PubMed 16024787. Source: MGI

small molecule metabolic process

Traceable author statement. Source: Reactome

synaptic transmission

Traceable author statement. Source: Reactome

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentbasolateral plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867. Source: UniProt

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

membrane

Traceable author statement Ref.1. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functioncholine transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

organic cation transmembrane transporter activity

Inferred from direct assay PubMed 16024787. Source: MGI

quaternary ammonium group transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

steroid binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O15244-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O15244-2)

Also known as: OCT2-A;

The sequence of this isoform differs from the canonical sequence as follows:
     427-483: DLQWLKIIIS...CDIGGIITPF → GKFQVKLESY...SEQIHMASLL
     484-555: Missing.
Isoform 3 (identifier: O15244-3)

The sequence of this isoform differs from the canonical sequence as follows:
     225-242: ITEFVGRRYRRTVGIFYQ → SKNVCACNCENKATSLPK
     243-555: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Solute carrier family 22 member 2
PRO_0000320957

Regions

Topological domain1 – 2222Cytoplasmic Potential
Transmembrane23 – 4321Helical; Potential
Topological domain44 – 150107Extracellular Potential
Transmembrane151 – 17121Helical; Potential
Topological domain172 – 1776Cytoplasmic Potential
Transmembrane178 – 19821Helical; Potential
Topological domain199 – 20810Extracellular Potential
Transmembrane209 – 22921Helical; Potential
Topological domain230 – 2389Cytoplasmic Potential
Transmembrane239 – 25921Helical; Potential
Topological domain260 – 2634Extracellular Potential
Transmembrane264 – 28421Helical; Potential
Topological domain285 – 34864Cytoplasmic Potential
Transmembrane349 – 36921Helical; Potential
Topological domain370 – 3756Extracellular Potential
Transmembrane376 – 39621Helical; Potential
Topological domain397 – 41418Cytoplasmic Potential
Transmembrane415 – 43521Helical; Potential
Topological domain436 – 4416Extracellular Potential
Transmembrane442 – 46221Helical; Potential
Topological domain463 – 4642Cytoplasmic Potential
Transmembrane465 – 48521Helical; Potential
Topological domain486 – 4949Extracellular Potential
Transmembrane495 – 51521Helical; Potential
Topological domain516 – 55540Cytoplasmic Potential

Sites

Site4511Involved in recognition of organic cations and participates in structural changes that occur during translocation of organic cations By similarity

Amino acid modifications

Glycosylation721N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence225 – 24218ITEFV…GIFYQ → SKNVCACNCENKATSLPK in isoform 3.
VSP_031771
Alternative sequence243 – 555313Missing in isoform 3.
VSP_031772
Alternative sequence427 – 48357DLQWL…IITPF → GKFQVKLESYLQDPGERECH GPLIGKPCNLSSKSIWKDKL EGSIWDPSEQIHMASLL in isoform 2.
VSP_031773
Alternative sequence484 – 55572Missing in isoform 2.
VSP_031774
Natural variant541P → S. Ref.23
Corresponds to variant rs8177504 [ dbSNP | Ensembl ].
VAR_039322
Natural variant1651M → I Lower Vmax. Ref.23
Corresponds to variant rs8177507 [ dbSNP | Ensembl ].
VAR_039323
Natural variant2011T → M. Ref.24
Corresponds to variant rs145450955 [ dbSNP | Ensembl ].
VAR_039324
Natural variant2701S → A Increased Ki value for TBA inhibition of MPP. Ref.1 Ref.2 Ref.3 Ref.6 Ref.23 Ref.24
Corresponds to variant rs316019 [ dbSNP | Ensembl ].
VAR_039325
Natural variant2971A → G.
Corresponds to variant rs8177513 [ dbSNP | Ensembl ].
VAR_039326
Natural variant4001R → C Lower Vmax and reduced Ki value for TBA inhibition of MPP. Ref.23
Corresponds to variant rs8177516 [ dbSNP | Ensembl ].
VAR_039327
Natural variant4321K → Q Lower Km value for MPP and reduced Ki value for TBA inhibition of MPP. Ref.23
Corresponds to variant rs8177517 [ dbSNP | Ensembl ].
VAR_039328
Natural variant4631R → K.
Corresponds to variant rs3907239 [ dbSNP | Ensembl ].
VAR_039329

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: 06528F9519CE211E

FASTA55562,581
        10         20         30         40         50         60 
MPTTVDDVLE HGGEFHFFQK QMFFLLALLS ATFAPIYVGI VFLGFTPDHR CRSPGVAELS 

        70         80         90        100        110        120 
LRCGWSPAEE LNYTVPGPGP AGEASPRQCR RYEVDWNQST FDCVDPLASL DTNRSRLPLG 

       130        140        150        160        170        180 
PCRDGWVYET PGSSIVTEFN LVCANSWMLD LFQSSVNVGF FIGSMSIGYI ADRFGRKLCL 

       190        200        210        220        230        240 
LTTVLINAAA GVLMAISPTY TWMLIFRLIQ GLVSKAGWLI GYILITEFVG RRYRRTVGIF 

       250        260        270        280        290        300 
YQVAYTVGLL VLAGVAYALP HWRWLQFTVS LPNFFFLLYY WCIPESPRWL ISQNKNAEAM 

       310        320        330        340        350        360 
RIIKHIAKKN GKSLPASLQR LRLEEETGKK LNPSFLDLVR TPQIRKHTMI LMYNWFTSSV 

       370        380        390        400        410        420 
LYQGLIMHMG LAGDNIYLDF FYSALVEFPA AFMIILTIDR IGRRYPWAAS NMVAGAACLA 

       430        440        450        460        470        480 
SVFIPGDLQW LKIIISCLGR MGITMAYEIV CLVNAELYPT FIRNLGVHIC SSMCDIGGII 

       490        500        510        520        530        540 
TPFLVYRLTN IWLELPLMVF GVLGLVAGGL VLLLPETKGK ALPETIEEAE NMQRPRKNKE 

       550 
KMIYLQVQKL DIPLN 

« Hide

Isoform 2 (OCT2-A) [UniParc].

Checksum: 0AD53D9697B4E7B2
Show »

FASTA48354,475
Isoform 3 [UniParc].

Checksum: 510EAB0C05C06B43
Show »

FASTA24226,685

References

« Hide 'large scale' references
[1]"Cloning and characterization of two human polyspecific organic cation transporters."
Gorboulev V., Ulzheimer J.C., Akhoundova A., Ulzheimer-Teuber I., Karbach U., Quester S., Baumann C., Lang F., Busch A.E., Koepsell H.
DNA Cell Biol. 16:871-881(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, VARIANT ALA-270.
Tissue: Kidney cortex.
[2]"cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney."
Urakami Y., Akazawa M., Saito H., Okuda M., Inui K.
J. Am. Soc. Nephrol. 13:1703-1710(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, VARIANT ALA-270.
Tissue: Kidney.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-270.
Tissue: Kidney.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ALA-270.
Tissue: Colon and Kidney.
[7]"Gene structures of the human non-neuronal monoamine transporters EMT and OCT2."
Gruendemann D., Schoemig E.
Hum. Genet. 106:627-635(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-138.
[8]"Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine."
Busch A.E., Karbach U., Miska D., Gorboulev V., Akhoundova A., Volk C., Arndt P., Ulzheimer J.C., Sonders M.S., Baumann C., Waldegger S., Lang F., Koepsell H.
Mol. Pharmacol. 54:342-352(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
[9]"Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules."
Urakami Y., Okuda M., Masuda S., Akazawa M., Saito H., Inui K.
Pharm. Res. 18:1528-1534(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: BIOPHYSICOCHEMICAL PROPERTIES.
[10]"Gene expression levels and immunolocalization of organic ion transporters in the human kidney."
Motohashi H., Sakurai Y., Saito H., Masuda S., Urakami Y., Goto M., Fukatsu A., Ogawa O., Inui K.
J. Am. Soc. Nephrol. 13:866-874(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[11]"Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2)."
Grundemann D., Hahne C., Berkels R., Schomig E.
J. Pharmacol. Exp. Ther. 304:810-817(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
[12]"Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A)."
Motohashi H., Uwai Y., Hiramoto K., Okuda M., Inui K.
Eur. J. Pharmacol. 503:25-30(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[13]"Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2."
Ciarimboli G., Ludwig T., Lang D., Pavenstaedt H., Koepsell H., Piechota H.J., Haier J., Jaehde U., Zisowsky J., Schlatter E.
Am. J. Pathol. 167:1477-1484(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[14]"Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1."
Kimura N., Masuda S., Tanihara Y., Ueo H., Okuda M., Katsura T., Inui K.
Drug Metab. Pharmacokinet. 20:379-386(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
[15]"A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters."
Tahara H., Kusuhara H., Endou H., Koepsell H., Imaoka T., Fuse E., Sugiyama Y.
J. Pharmacol. Exp. Ther. 315:337-345(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
[16]"Metformin transport by renal basolateral organic cation transporter hOCT2."
Kimura N., Okuda M., Inui K.
Pharm. Res. 22:255-259(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
[17]"Characterization of regulatory mechanisms and states of human organic cation transporter 2."
Biermann J., Lang D., Gorboulev V., Koepsell H., Sindic A., Schroter R., Zvirbliene A., Pavenstadt H., Schlatter E., Ciarimboli G.
Am. J. Physiol. 290:C1521-C1531(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
[18]"Organic cation transporters are determinants of oxaliplatin cytotoxicity."
Zhang S., Lovejoy K.S., Shima J.E., Lagpacan L.L., Shu Y., Lapuk A., Chen Y., Komori T., Gray J.W., Chen X., Lippard S.J., Giacomini K.M.
Cancer Res. 66:8847-8857(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[19]"Interactions of fluoroquinolone antibacterials, DX-619 and levofloxacin, with creatinine transport by renal organic cation transporter hOCT2."
Okuda M., Kimura N., Inui K.
Drug Metab. Pharmacokinet. 21:432-436(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[20]"Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family)."
Yonezawa A., Masuda S., Yokoo S., Katsura T., Inui K.
J. Pharmacol. Exp. Ther. 319:879-886(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[21]"Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity."
Yokoo S., Yonezawa A., Masuda S., Fukatsu A., Katsura T., Inui K.
Biochem. Pharmacol. 74:477-487(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[22]"The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua."
Bottalico B., Noskova V., Pilka R., Larsson I., Domanski H., Casslen B., Hansson S.R.
Mol. Reprod. Dev. 74:1303-1311(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[23]"Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function."
Leabman M.K., Huang C.C., Kawamoto M., Johns S.J., Stryke D., Ferrin T.E., DeYoung J., Taylor T., Clark A.G., Herskowitz I., Giacomini K.M.
Pharmacogenetics 12:395-405(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT SER-54, CHARACTERIZATION OF VARIANTS ILE-165; ALA-270; CYS-400 AND GLN-432.
[24]"Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin."
Shikata E., Yamamoto R., Takane H., Shigemasa C., Ikeda T., Otsubo K., Ieiri I.
J. Hum. Genet. 52:117-122(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS MET-201 AND ALA-270.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X98333 mRNA. Translation: CAA66978.1.
AB075951 mRNA. Translation: BAC02720.1.
AK290787 mRNA. Translation: BAF83476.1.
AL162582 Genomic DNA. Translation: CAI20003.1.
CH471051 Genomic DNA. Translation: EAW47602.1.
BC030978 mRNA. Translation: AAH30978.1.
BC039899 mRNA. Translation: AAH39899.1.
AJ251885 Genomic DNA. Translation: CAB96133.1.
RefSeqNP_003049.2. NM_003058.3.
UniGeneHs.436385.

3D structure databases

ProteinModelPortalO15244.
SMRO15244. Positions 144-524.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112469. 8 interactions.
IntActO15244. 8 interactions.
STRING9606.ENSP00000355920.

Chemistry

ChEMBLCHEMBL1743122.

Protein family/group databases

TCDB2.A.1.19.30. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteO15244.

Proteomic databases

PaxDbO15244.
PRIDEO15244.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000366953; ENSP00000355920; ENSG00000112499. [O15244-1]
GeneID6582.
KEGGhsa:6582.
UCSCuc003qtf.3. human. [O15244-1]
uc003qth.2. human. [O15244-3]

Organism-specific databases

CTD6582.
GeneCardsGC06M160592.
H-InvDBHIX0025014.
HGNCHGNC:10966. SLC22A2.
HPAHPA008567.
MIM602608. gene.
neXtProtNX_O15244.
PharmGKBPA331.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000234568.
HOVERGENHBG061545.
InParanoidO15244.
KOK08199.
OMAKAGWLIS.
OrthoDBEOG78PV8N.
PhylomeDBO15244.
TreeFamTF315847.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_13685. Neuronal System.
REACT_15518. Transmembrane transport of small molecules.
REACT_20679. Amine compound SLC transporters.

Gene expression databases

ArrayExpressO15244.
BgeeO15244.
CleanExHS_SLC22A2.
GenevestigatorO15244.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
TIGRFAMsTIGR00898. 2A0119. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC22A2.
GenomeRNAi6582.
NextBio25613.
PROO15244.
SOURCESearch...

Entry information

Entry nameS22A2_HUMAN
AccessionPrimary (citable) accession number: O15244
Secondary accession number(s): Q5T7Q6 expand/collapse secondary AC list , Q6PIQ8, Q8NG62, Q9NQB9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM