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Protein

Leptin receptor gene-related protein

Gene

LEPROT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.2 Publications

GO - Molecular functioni

  • receptor binding Source: UniProtKB

GO - Biological processi

  • negative regulation of growth hormone receptor signaling pathway Source: UniProtKB
  • negative regulation of JAK-STAT cascade Source: UniProtKB
  • negative regulation of protein localization to cell surface Source: UniProtKB
  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leptin receptor gene-related protein
Alternative name(s):
Endospanin-1
Leptin receptor overlapping transcript protein
OB-R gene-related protein
Short name:
OB-RGRP
Gene namesi
Name:LEPROT
Synonyms:LEPR, OBR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29477. LEPROT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence analysisAdd
BLAST
Transmembranei32 – 5221HelicalSequence analysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endosome Source: UniProtKB
  • endosome membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134913422.

Polymorphism and mutation databases

BioMutaiLEPROT.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Leptin receptor gene-related proteinPRO_0000215194Add
BLAST

Proteomic databases

MaxQBiO15243.
PaxDbiO15243.
PeptideAtlasiO15243.
PRIDEiO15243.

PTM databases

SwissPalmiO15243.

Expressioni

Tissue specificityi

Expressed at the highest levels in heart and placenta and at a lesser extent in lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiO15243.
CleanExiHS_LEPR.
ExpressionAtlasiO15243. baseline and differential.
GenevisibleiO15243. HS.

Interactioni

Subunit structurei

Interacts with LEPR. Interacts with RAB13 (By similarity).By similarity

GO - Molecular functioni

  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120123. 1 interaction.
DIPiDIP-29969N.
STRINGi9606.ENSP00000360104.

Structurei

3D structure databases

ProteinModelPortaliO15243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OB-RGRP/VPS55 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2174. Eukaryota.
ENOG4111UCZ. LUCA.
GeneTreeiENSGT00390000006503.
HOGENOMiHOG000038515.
HOVERGENiHBG001034.
InParanoidiO15243.
OrthoDBiEOG76QFK9.
PhylomeDBiO15243.
TreeFamiTF313689.

Family and domain databases

InterProiIPR007262. VPS55.
[Graphical view]
PANTHERiPTHR12050. PTHR12050. 1 hit.
PfamiPF04133. Vps55. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15243-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVKALVAL SFSGAIGLTF LMLGCALEDY GVYWPLFVLI FHAISPIPHF
60 70 80 90 100
IAKRVTYDSD ATSSACRELA YFFTTGIVVS AFGFPVILAR VAVIKWGACG
110 120 130
LVLAGNAVIF LTIQGFFLIF GRGDDFSWEQ W
Length:131
Mass (Da):14,254
Last modified:January 1, 1998 - v1
Checksum:i0F9CE741C2C5ED9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12670 mRNA. Translation: CAA73211.1.
CR541647 mRNA. Translation: CAG46448.1.
CR541737 mRNA. Translation: CAG46537.1.
AK074841 mRNA. Translation: BAG52014.1.
AC119800 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06527.1.
CH471059 Genomic DNA. Translation: EAX06531.1.
BC011027 mRNA. Translation: AAH11027.2.
BC056250 mRNA. Translation: AAH56250.1.
CCDSiCCDS630.1.
RefSeqiNP_001185612.1. NM_001198683.1.
NP_059996.1. NM_017526.4.
UniGeneiHs.23581.
Hs.258228.

Genome annotation databases

EnsembliENST00000371065; ENSP00000360104; ENSG00000213625.
GeneIDi54741.
KEGGihsa:54741.
UCSCiuc001dcf.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12670 mRNA. Translation: CAA73211.1.
CR541647 mRNA. Translation: CAG46448.1.
CR541737 mRNA. Translation: CAG46537.1.
AK074841 mRNA. Translation: BAG52014.1.
AC119800 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06527.1.
CH471059 Genomic DNA. Translation: EAX06531.1.
BC011027 mRNA. Translation: AAH11027.2.
BC056250 mRNA. Translation: AAH56250.1.
CCDSiCCDS630.1.
RefSeqiNP_001185612.1. NM_001198683.1.
NP_059996.1. NM_017526.4.
UniGeneiHs.23581.
Hs.258228.

3D structure databases

ProteinModelPortaliO15243.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120123. 1 interaction.
DIPiDIP-29969N.
STRINGi9606.ENSP00000360104.

PTM databases

SwissPalmiO15243.

Polymorphism and mutation databases

BioMutaiLEPROT.

Proteomic databases

MaxQBiO15243.
PaxDbiO15243.
PeptideAtlasiO15243.
PRIDEiO15243.

Protocols and materials databases

DNASUi54741.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371065; ENSP00000360104; ENSG00000213625.
GeneIDi54741.
KEGGihsa:54741.
UCSCiuc001dcf.4. human.

Organism-specific databases

CTDi54741.
GeneCardsiLEPROT.
HGNCiHGNC:29477. LEPROT.
MIMi613461. gene.
neXtProtiNX_O15243.
PharmGKBiPA134913422.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2174. Eukaryota.
ENOG4111UCZ. LUCA.
GeneTreeiENSGT00390000006503.
HOGENOMiHOG000038515.
HOVERGENiHBG001034.
InParanoidiO15243.
OrthoDBiEOG76QFK9.
PhylomeDBiO15243.
TreeFamiTF313689.

Miscellaneous databases

ChiTaRSiLEPROT. human.
GenomeRNAii54741.
PROiO15243.
SOURCEiSearch...

Gene expression databases

BgeeiO15243.
CleanExiHS_LEPR.
ExpressionAtlasiO15243. baseline and differential.
GenevisibleiO15243. HS.

Family and domain databases

InterProiIPR007262. VPS55.
[Graphical view]
PANTHERiPTHR12050. PTHR12050. 1 hit.
PfamiPF04133. Vps55. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The leptin receptor promoter controls expression of a second distinct protein."
    Bailleul B., Akerblom I., Strosberg A.D.
    Nucleic Acids Res. 25:2752-2758(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate and Skeletal muscle.
  7. "Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity."
    Couturier C., Sarkis C., Seron K., Belouzard S., Chen P., Lenain A., Corset L., Dam J., Vauthier V., Dubart A., Mallet J., Froguel P., Rouille Y., Jockers R.
    Proc. Natl. Acad. Sci. U.S.A. 104:19476-19481(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. Cited for: FUNCTION.

Entry informationi

Entry nameiOBRG_HUMAN
AccessioniPrimary (citable) accession number: O15243
Secondary accession number(s): Q6FHL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

This protein is encoded by LEPR gene, but shares with LEPR only the first two 5'-UTR exons. It therefore does not share any sequence similarity with LEPR.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.