SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O15240

- VGF_HUMAN

UniProt

O15240 - VGF_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Neurosecretory protein VGF
Gene
VGF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system By similarity.2 Publications
NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release.2 Publications
Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.2 Publications

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
  2. generation of precursor metabolites and energy Source: Ensembl
  3. glucose homeostasis Source: Ensembl
  4. insulin secretion Source: Ensembl
  5. ovarian follicle development Source: Ensembl
  6. response to cAMP Source: UniProtKB
  7. response to cold Source: Ensembl
  8. response to dietary excess Source: Ensembl
  9. response to insulin Source: Ensembl
  10. sexual reproduction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Neurosecretory protein VGF
Cleaved into the following 3 chains:
Gene namesi
Name:VGF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:12684. VGF.

Subcellular locationi

Secreted. Cytoplasmic vesiclesecretory vesicle
Note: Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.1 Publication

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB
  2. extracellular space Source: UniProtKB
  3. transport vesicle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 615593Neurosecretory protein VGF
PRO_0000022655Add
BLAST
Peptidei281 – 30626Neuroendocrine regulatory peptide-1
PRO_0000403364Add
BLAST
Peptidei310 – 34738Neuroendocrine regulatory peptide-2
PRO_0000403365Add
BLAST
Peptidei554 – 57724Antimicrobial peptide VGF[554-577]1 Publication
PRO_0000422072Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei310 – 3101Pyrrolidone carboxylic acid
Modified residuei577 – 5771Proline amide1 Publication

Post-translational modificationi

Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure By similarity.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiO15240.
PaxDbiO15240.
PeptideAtlasiO15240.
PRIDEiO15240.

PTM databases

PhosphoSiteiO15240.

Expressioni

Tissue specificityi

Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.1 Publication

Gene expression databases

BgeeiO15240.
CleanExiHS_VGF.
GenevestigatoriO15240.

Organism-specific databases

HPAiHPA055177.

Interactioni

Protein-protein interaction databases

BioGridi113268. 4 interactions.
STRINGi9606.ENSP00000249330.

Structurei

3D structure databases

ProteinModelPortaliO15240.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi353 – 44795Asp/Glu-rich (acidic)
Add
BLAST

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG75774.
HOGENOMiHOG000120127.
HOVERGENiHBG006806.
InParanoidiO15240.
OMAiLPEAHQF.
OrthoDBiEOG7W9RV0.
PhylomeDBiO15240.
TreeFamiTF338498.

Family and domain databases

InterProiIPR026128. VGF.
[Graphical view]
PANTHERiPTHR15159. PTHR15159. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15240-1 [UniParc]FASTAAdd to Basket

« Hide

MKALRLSASA LFCLLLINGL GAAPPGRPEA QPPPLSSEHK EPVAGDAVPG    50
PKDGSAPEVR GARNSEPQDE GELFQGVDPR ALAAVLLQAL DRPASPPAPS 100
GSQQGPEEEA AEALLTETVR SQTHSLPAPE SPEPAAPPRP QTPENGPEAS 150
DPSEELEALA SLLQELRDFS PSSAKRQQET AAAETETRTH TLTRVNLESP 200
GPERVWRASW GEFQARVPER APLPPPAPSQ FQARMPDSGP LPETHKFGEG 250
VSSPKTHLGE ALAPLSKAYQ GVAAPFPKAR RPESALLGGS EAGERLLQQG 300
LAQVEAGRRQ AEATRQAAAQ EERLADLASD LLLQYLLQGG ARQRGLGGRG 350
LQEAAEERES AREEEEAEQE RRGGEERVGE EDEEAAEAEA EAEEAERARQ 400
NALLFAEEED GEAGAEDKRS QEETPGHRRK EAEGTEEGGE EEDDEEMDPQ 450
TIDSLIELST KLHLPADDVV SIIEEVEEKR KRKKNAPPEP VPPPRAAPAP 500
THVRSPQPPP PAPAPARDEL PDWNEVLPPW DREEDEVYPP GPYHPFPNYI 550
RPRTLQPPSA LRRRHYHHAL PPSRHYPGRE AQARRAQEEA EAEERRLQEQ 600
EELENYIEHV LLRRP 615
Length:615
Mass (Da):67,258
Last modified:September 23, 2008 - v2
Checksum:i198097C5622AC087
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti129 – 1313PES → AGE in CAA73210. 1 Publication
Sequence conflicti282 – 2821P → A in CAA73210. 1 Publication
Sequence conflicti387 – 3871E → EA in CAA73210. 1 Publication
Sequence conflicti393 – 3931E → D in CAA73210. 1 Publication
Sequence conflicti481 – 4811K → N in CAA73210. 1 Publication
Sequence conflicti485 – 4851N → K in CAA73210. 1 Publication
Sequence conflicti512 – 5154APAP → PPS in CAA73210. 1 Publication
Sequence conflicti585 – 5862RA → HAQ in CAA73210. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12661 Genomic DNA. Translation: CAA73210.1.
AC004876 Genomic DNA. Translation: AAD45830.1.
CH471197 Genomic DNA. Translation: EAW50201.1.
BC063835 mRNA. Translation: AAH63835.1.
CCDSiCCDS5712.1.
RefSeqiNP_003369.2. NM_003378.3.
XP_005250617.1. XM_005250560.2.
XP_005250618.1. XM_005250561.2.
UniGeneiHs.587325.

Genome annotation databases

EnsembliENST00000249330; ENSP00000249330; ENSG00000128564.
ENST00000445482; ENSP00000400884; ENSG00000128564.
GeneIDi7425.
KEGGihsa:7425.
UCSCiuc003uxx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12661 Genomic DNA. Translation: CAA73210.1 .
AC004876 Genomic DNA. Translation: AAD45830.1 .
CH471197 Genomic DNA. Translation: EAW50201.1 .
BC063835 mRNA. Translation: AAH63835.1 .
CCDSi CCDS5712.1.
RefSeqi NP_003369.2. NM_003378.3.
XP_005250617.1. XM_005250560.2.
XP_005250618.1. XM_005250561.2.
UniGenei Hs.587325.

3D structure databases

ProteinModelPortali O15240.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113268. 4 interactions.
STRINGi 9606.ENSP00000249330.

PTM databases

PhosphoSitei O15240.

Proteomic databases

MaxQBi O15240.
PaxDbi O15240.
PeptideAtlasi O15240.
PRIDEi O15240.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000249330 ; ENSP00000249330 ; ENSG00000128564 .
ENST00000445482 ; ENSP00000400884 ; ENSG00000128564 .
GeneIDi 7425.
KEGGi hsa:7425.
UCSCi uc003uxx.4. human.

Organism-specific databases

CTDi 7425.
GeneCardsi GC07M100805.
HGNCi HGNC:12684. VGF.
HPAi HPA055177.
MIMi 602186. gene.
neXtProti NX_O15240.
PharmGKBi PA37305.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG75774.
HOGENOMi HOG000120127.
HOVERGENi HBG006806.
InParanoidi O15240.
OMAi LPEAHQF.
OrthoDBi EOG7W9RV0.
PhylomeDBi O15240.
TreeFami TF338498.

Miscellaneous databases

GenomeRNAii 7425.
NextBioi 29086.
PROi O15240.
SOURCEi Search...

Gene expression databases

Bgeei O15240.
CleanExi HS_VGF.
Genevestigatori O15240.

Family and domain databases

InterProi IPR026128. VGF.
[Graphical view ]
PANTHERi PTHR15159. PTHR15159. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, structural organization analysis and chromosomal assignment of the human gene for neurosecretory protein VGF."
    Canu N., Possenti R., Ricco A.S., Rocchi M., Levi A.
    Genomics 45:443-446(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.
  5. "Large-scale identification of endogenous secretory peptides using electron transfer dissociation mass spectrometry."
    Sasaki K., Osaki T., Minamino N.
    Mol. Cell. Proteomics 12:700-709(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 554-577, FUNCTION, AMIDATION AT PRO-577.
  6. "Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGF."
    Toshinai K., Nakazato M.
    Cell. Mol. Life Sci. 66:1939-1945(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF PEPTIDES NERP-1 AND NERP-2, PYROGLUTAMATE FORMATION AT GLN-310, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiVGF_HUMAN
AccessioniPrimary (citable) accession number: O15240
Secondary accession number(s): Q9UDW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi