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O15235

- RT12_HUMAN

UniProt

O15235 - RT12_HUMAN

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Protein

28S ribosomal protein S12, mitochondrial

Gene

MRPS12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: ProtInc

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S12, mitochondrial
Short name:
MRP-S12
Short name:
S12mt
Alternative name(s):
MT-RPS12
Gene namesi
Name:MRPS12
Synonyms:RPMS12, RPSM12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:10380. MRPS12.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial ribosome Source: ProtInc
  2. small ribosomal subunit Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929MitochondrionSequence AnalysisAdd
BLAST
Chaini30 – 13810928S ribosomal protein S12, mitochondrialPRO_0000030606Add
BLAST

Proteomic databases

MaxQBiO15235.
PaxDbiO15235.
PeptideAtlasiO15235.
PRIDEiO15235.

PTM databases

PhosphoSiteiO15235.

Expressioni

Gene expression databases

BgeeiO15235.
CleanExiHS_MRPS12.
GenevestigatoriO15235.

Organism-specific databases

HPAiHPA046775.
HPA050633.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Binary interactionsi

WithEntry#Exp.IntActNotes
SPINK7P580623EBI-712205,EBI-1182445

Protein-protein interaction databases

BioGridi112098. 7 interactions.
IntActiO15235. 5 interactions.
MINTiMINT-1373561.
STRINGi9606.ENSP00000308845.

Structurei

3D structure databases

ProteinModelPortaliO15235.
SMRiO15235. Positions 31-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S12P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0048.
GeneTreeiENSGT00550000075103.
HOGENOMiHOG000040063.
HOVERGENiHBG001525.
InParanoidiO15235.
KOiK02950.
OrthoDBiEOG7Z69F2.
PhylomeDBiO15235.
TreeFamiTF315095.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSiPR01034. RIBOSOMALS12.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15235-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWSGLLHGL NTSLTCGPAL VPRLWATCSM ATLNQMHRLG PPKRPPRKLG
60 70 80 90 100
PTEGRPQLKG VVLCTFTRKP KKPNSANRKC CRVRLSTGRE AVCFIPGEGH
110 120 130
TLQEHQIVLV EGGRTQDLPG VKLTVVRGKY DCGHVQKK
Length:138
Mass (Da):15,173
Last modified:January 1, 1998 - v1
Checksum:i893FD2CA1C7187A7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81H → R.
Corresponds to variant rs33988199 [ dbSNP | Ensembl ].
VAR_051820

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11681 mRNA. Translation: CAA72377.1.
AF058761 Genomic DNA. Translation: AAC64704.1.
CR407609 mRNA. Translation: CAG28537.1.
CH471126 Genomic DNA. Translation: EAW56849.1.
BC001617 mRNA. Translation: AAH01617.1.
BC006424 mRNA. Translation: AAH06424.1.
BC007499 mRNA. Translation: AAH07499.1.
CCDSiCCDS12525.1.
RefSeqiNP_066930.1. NM_021107.1.
NP_203526.1. NM_033362.3.
NP_203527.1. NM_033363.1.
UniGeneiHs.411125.

Genome annotation databases

EnsembliENST00000308018; ENSP00000308845; ENSG00000128626.
ENST00000402029; ENSP00000384579; ENSG00000128626.
ENST00000407800; ENSP00000384952; ENSG00000128626.
GeneIDi6183.
KEGGihsa:6183.
UCSCiuc002okc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11681 mRNA. Translation: CAA72377.1 .
AF058761 Genomic DNA. Translation: AAC64704.1 .
CR407609 mRNA. Translation: CAG28537.1 .
CH471126 Genomic DNA. Translation: EAW56849.1 .
BC001617 mRNA. Translation: AAH01617.1 .
BC006424 mRNA. Translation: AAH06424.1 .
BC007499 mRNA. Translation: AAH07499.1 .
CCDSi CCDS12525.1.
RefSeqi NP_066930.1. NM_021107.1.
NP_203526.1. NM_033362.3.
NP_203527.1. NM_033363.1.
UniGenei Hs.411125.

3D structure databases

ProteinModelPortali O15235.
SMRi O15235. Positions 31-138.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112098. 7 interactions.
IntActi O15235. 5 interactions.
MINTi MINT-1373561.
STRINGi 9606.ENSP00000308845.

PTM databases

PhosphoSitei O15235.

Proteomic databases

MaxQBi O15235.
PaxDbi O15235.
PeptideAtlasi O15235.
PRIDEi O15235.

Protocols and materials databases

DNASUi 6183.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308018 ; ENSP00000308845 ; ENSG00000128626 .
ENST00000402029 ; ENSP00000384579 ; ENSG00000128626 .
ENST00000407800 ; ENSP00000384952 ; ENSG00000128626 .
GeneIDi 6183.
KEGGi hsa:6183.
UCSCi uc002okc.3. human.

Organism-specific databases

CTDi 6183.
GeneCardsi GC19P039422.
HGNCi HGNC:10380. MRPS12.
HPAi HPA046775.
HPA050633.
MIMi 603021. gene.
neXtProti NX_O15235.
PharmGKBi PA30996.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0048.
GeneTreei ENSGT00550000075103.
HOGENOMi HOG000040063.
HOVERGENi HBG001525.
InParanoidi O15235.
KOi K02950.
OrthoDBi EOG7Z69F2.
PhylomeDBi O15235.
TreeFami TF315095.

Miscellaneous databases

GeneWikii MRPS12.
GenomeRNAii 6183.
NextBioi 24009.
PROi O15235.
SOURCEi Search...

Gene expression databases

Bgeei O15235.
CleanExi HS_MRPS12.
Genevestigatori O15235.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
InterProi IPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view ]
PANTHERi PTHR11652. PTHR11652. 1 hit.
Pfami PF00164. Ribosom_S12_S23. 1 hit.
[Graphical view ]
PIRSFi PIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSi PR01034. RIBOSOMALS12.
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00981. rpsL_bact. 1 hit.
PROSITEi PS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Metazoan nuclear genes for mitoribosomal protein S12."
    Shah Z.H., O'Dell K.M., Miller S.C.M., An X., Jacobs H.T.
    Gene 204:55-62(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Characterization of the human mitochondrial ribosomal S12 gene."
    Johnson D.F., Hamon M., Fischel-Ghodsian N.
    Genomics 52:363-368(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Colon and Skin.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT12_HUMAN
AccessioniPrimary (citable) accession number: O15235
Secondary accession number(s): Q53X98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3