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O15235 (RT12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
28S ribosomal protein S12, mitochondrial

Short name=MRP-S12
Short name=S12mt
Alternative name(s):
MT-RPS12
Gene names
Name:MRPS12
Synonyms:RPMS12, RPSM12
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the ribosomal protein S12P family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SPINK7P580623EBI-712205,EBI-1182445

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2929Mitochondrion Potential
Chain30 – 13810928S ribosomal protein S12, mitochondrial
PRO_0000030606

Natural variations

Natural variant81H → R.
Corresponds to variant rs33988199 [ dbSNP | Ensembl ].
VAR_051820

Sequences

Sequence LengthMass (Da)Tools
O15235 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 893FD2CA1C7187A7

FASTA13815,173
        10         20         30         40         50         60 
MSWSGLLHGL NTSLTCGPAL VPRLWATCSM ATLNQMHRLG PPKRPPRKLG PTEGRPQLKG 

        70         80         90        100        110        120 
VVLCTFTRKP KKPNSANRKC CRVRLSTGRE AVCFIPGEGH TLQEHQIVLV EGGRTQDLPG 

       130 
VKLTVVRGKY DCGHVQKK 

« Hide

References

« Hide 'large scale' references
[1]"Metazoan nuclear genes for mitoribosomal protein S12."
Shah Z.H., O'Dell K.M., Miller S.C.M., An X., Jacobs H.T.
Gene 204:55-62(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Characterization of the human mitochondrial ribosomal S12 gene."
Johnson D.F., Hamon M., Fischel-Ghodsian N.
Genomics 52:363-368(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Colon and Skin.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y11681 mRNA. Translation: CAA72377.1.
AF058761 Genomic DNA. Translation: AAC64704.1.
CR407609 mRNA. Translation: CAG28537.1.
CH471126 Genomic DNA. Translation: EAW56849.1.
BC001617 mRNA. Translation: AAH01617.1.
BC006424 mRNA. Translation: AAH06424.1.
BC007499 mRNA. Translation: AAH07499.1.
CCDSCCDS12525.1.
RefSeqNP_066930.1. NM_021107.1.
NP_203526.1. NM_033362.3.
NP_203527.1. NM_033363.1.
UniGeneHs.411125.

3D structure databases

ProteinModelPortalO15235.
SMRO15235. Positions 53-138.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112098. 8 interactions.
IntActO15235. 5 interactions.
MINTMINT-1373561.
STRING9606.ENSP00000308845.

PTM databases

PhosphoSiteO15235.

Proteomic databases

MaxQBO15235.
PaxDbO15235.
PeptideAtlasO15235.
PRIDEO15235.

Protocols and materials databases

DNASU6183.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308018; ENSP00000308845; ENSG00000128626.
ENST00000402029; ENSP00000384579; ENSG00000128626.
ENST00000407800; ENSP00000384952; ENSG00000128626.
GeneID6183.
KEGGhsa:6183.
UCSCuc002okc.3. human.

Organism-specific databases

CTD6183.
GeneCardsGC19P039422.
HGNCHGNC:10380. MRPS12.
HPAHPA046775.
HPA050633.
MIM603021. gene.
neXtProtNX_O15235.
PharmGKBPA30996.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0048.
HOGENOMHOG000040063.
HOVERGENHBG001525.
InParanoidO15235.
KOK02950.
OrthoDBEOG7Z69F2.
PhylomeDBO15235.
TreeFamTF315095.

Gene expression databases

BgeeO15235.
CleanExHS_MRPS12.
GenevestigatorO15235.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
InterProIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]
PANTHERPTHR11652. PTHR11652. 1 hit.
PfamPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFPIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSPR01034. RIBOSOMALS12.
SUPFAMSSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00981. rpsL_bact. 1 hit.
PROSITEPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMRPS12.
GenomeRNAi6183.
NextBio24009.
PROO15235.
SOURCESearch...

Entry information

Entry nameRT12_HUMAN
AccessionPrimary (citable) accession number: O15235
Secondary accession number(s): Q53X98
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM