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Protein

28S ribosomal protein S12, mitochondrial

Gene

MRPS12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128626-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S12, mitochondrial
Short name:
MRP-S12
Short name:
S12mt
Alternative name(s):
MT-RPS12
Gene namesi
Name:MRPS12
Synonyms:RPMS12, RPSM12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:10380. MRPS12.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial ribosome Source: ProtInc
  • mitochondrial small ribosomal subunit Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi6183.
OpenTargetsiENSG00000128626.
ENSG00000283018.
PharmGKBiPA30996.

Polymorphism and mutation databases

BioMutaiMRPS12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000003060630 – 13828S ribosomal protein S12, mitochondrialAdd BLAST109

Proteomic databases

EPDiO15235.
MaxQBiO15235.
PaxDbiO15235.
PeptideAtlasiO15235.
PRIDEiO15235.
TopDownProteomicsiO15235.

PTM databases

iPTMnetiO15235.
PhosphoSitePlusiO15235.

Expressioni

Gene expression databases

BgeeiENSG00000128626.
CleanExiHS_MRPS12.
ExpressionAtlasiO15235. baseline and differential.
GenevisibleiO15235. HS.

Organism-specific databases

HPAiHPA046775.
HPA050633.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Binary interactionsi

WithEntry#Exp.IntActNotes
SPINK7P580623EBI-712205,EBI-1182445

Protein-protein interaction databases

BioGridi112098. 16 interactors.
IntActiO15235. 16 interactors.
MINTiMINT-1373561.
STRINGi9606.ENSP00000308845.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AJ1-138[»]
ProteinModelPortaliO15235.
SMRiO15235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S12P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1750. Eukaryota.
COG0048. LUCA.
GeneTreeiENSGT00550000075103.
HOGENOMiHOG000040063.
HOVERGENiHBG001525.
InParanoidiO15235.
KOiK02950.
OMAiMHRQGKP.
OrthoDBiEOG091G0U3U.
PhylomeDBiO15235.
TreeFamiTF315095.

Family and domain databases

CDDicd03368. Ribosomal_S12. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PRINTSiPR01034. RIBOSOMALS12.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15235-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSGLLHGL NTSLTCGPAL VPRLWATCSM ATLNQMHRLG PPKRPPRKLG
60 70 80 90 100
PTEGRPQLKG VVLCTFTRKP KKPNSANRKC CRVRLSTGRE AVCFIPGEGH
110 120 130
TLQEHQIVLV EGGRTQDLPG VKLTVVRGKY DCGHVQKK
Length:138
Mass (Da):15,173
Last modified:January 1, 1998 - v1
Checksum:i893FD2CA1C7187A7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0518208H → R.Corresponds to variant rs33988199dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11681 mRNA. Translation: CAA72377.1.
AF058761 Genomic DNA. Translation: AAC64704.1.
CR407609 mRNA. Translation: CAG28537.1.
CH471126 Genomic DNA. Translation: EAW56849.1.
BC001617 mRNA. Translation: AAH01617.1.
BC006424 mRNA. Translation: AAH06424.1.
BC007499 mRNA. Translation: AAH07499.1.
CCDSiCCDS12525.1.
RefSeqiNP_066930.1. NM_021107.1.
NP_203526.1. NM_033362.3.
NP_203527.1. NM_033363.1.
UniGeneiHs.411125.

Genome annotation databases

EnsembliENST00000308018; ENSP00000308845; ENSG00000128626.
ENST00000402029; ENSP00000384579; ENSG00000128626.
ENST00000407800; ENSP00000384952; ENSG00000128626.
ENST00000634246; ENSP00000488926; ENSG00000283018.
ENST00000634400; ENSP00000489467; ENSG00000283018.
ENST00000634704; ENSP00000489374; ENSG00000283018.
GeneIDi6183.
KEGGihsa:6183.
UCSCiuc002okc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11681 mRNA. Translation: CAA72377.1.
AF058761 Genomic DNA. Translation: AAC64704.1.
CR407609 mRNA. Translation: CAG28537.1.
CH471126 Genomic DNA. Translation: EAW56849.1.
BC001617 mRNA. Translation: AAH01617.1.
BC006424 mRNA. Translation: AAH06424.1.
BC007499 mRNA. Translation: AAH07499.1.
CCDSiCCDS12525.1.
RefSeqiNP_066930.1. NM_021107.1.
NP_203526.1. NM_033362.3.
NP_203527.1. NM_033363.1.
UniGeneiHs.411125.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AJ1-138[»]
ProteinModelPortaliO15235.
SMRiO15235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112098. 16 interactors.
IntActiO15235. 16 interactors.
MINTiMINT-1373561.
STRINGi9606.ENSP00000308845.

PTM databases

iPTMnetiO15235.
PhosphoSitePlusiO15235.

Polymorphism and mutation databases

BioMutaiMRPS12.

Proteomic databases

EPDiO15235.
MaxQBiO15235.
PaxDbiO15235.
PeptideAtlasiO15235.
PRIDEiO15235.
TopDownProteomicsiO15235.

Protocols and materials databases

DNASUi6183.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308018; ENSP00000308845; ENSG00000128626.
ENST00000402029; ENSP00000384579; ENSG00000128626.
ENST00000407800; ENSP00000384952; ENSG00000128626.
ENST00000634246; ENSP00000488926; ENSG00000283018.
ENST00000634400; ENSP00000489467; ENSG00000283018.
ENST00000634704; ENSP00000489374; ENSG00000283018.
GeneIDi6183.
KEGGihsa:6183.
UCSCiuc002okc.4. human.

Organism-specific databases

CTDi6183.
DisGeNETi6183.
GeneCardsiMRPS12.
HGNCiHGNC:10380. MRPS12.
HPAiHPA046775.
HPA050633.
MIMi603021. gene.
neXtProtiNX_O15235.
OpenTargetsiENSG00000128626.
ENSG00000283018.
PharmGKBiPA30996.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1750. Eukaryota.
COG0048. LUCA.
GeneTreeiENSGT00550000075103.
HOGENOMiHOG000040063.
HOVERGENiHBG001525.
InParanoidiO15235.
KOiK02950.
OMAiMHRQGKP.
OrthoDBiEOG091G0U3U.
PhylomeDBiO15235.
TreeFamiTF315095.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128626-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

GeneWikiiMRPS12.
GenomeRNAii6183.
PROiO15235.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128626.
CleanExiHS_MRPS12.
ExpressionAtlasiO15235. baseline and differential.
GenevisibleiO15235. HS.

Family and domain databases

CDDicd03368. Ribosomal_S12. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PRINTSiPR01034. RIBOSOMALS12.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRT12_HUMAN
AccessioniPrimary (citable) accession number: O15235
Secondary accession number(s): Q53X98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.