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O15235

- RT12_HUMAN

UniProt

O15235 - RT12_HUMAN

Protein

28S ribosomal protein S12, mitochondrial

Gene

MRPS12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. structural constituent of ribosome Source: ProtInc

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    28S ribosomal protein S12, mitochondrial
    Short name:
    MRP-S12
    Short name:
    S12mt
    Alternative name(s):
    MT-RPS12
    Gene namesi
    Name:MRPS12
    Synonyms:RPMS12, RPSM12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:10380. MRPS12.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial ribosome Source: ProtInc
    2. small ribosomal subunit Source: InterPro

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30996.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2929MitochondrionSequence AnalysisAdd
    BLAST
    Chaini30 – 13810928S ribosomal protein S12, mitochondrialPRO_0000030606Add
    BLAST

    Proteomic databases

    MaxQBiO15235.
    PaxDbiO15235.
    PeptideAtlasiO15235.
    PRIDEiO15235.

    PTM databases

    PhosphoSiteiO15235.

    Expressioni

    Gene expression databases

    BgeeiO15235.
    CleanExiHS_MRPS12.
    GenevestigatoriO15235.

    Organism-specific databases

    HPAiHPA046775.
    HPA050633.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SPINK7P580623EBI-712205,EBI-1182445

    Protein-protein interaction databases

    BioGridi112098. 7 interactions.
    IntActiO15235. 5 interactions.
    MINTiMINT-1373561.
    STRINGi9606.ENSP00000308845.

    Structurei

    3D structure databases

    ProteinModelPortaliO15235.
    SMRiO15235. Positions 53-138.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S12P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0048.
    HOGENOMiHOG000040063.
    HOVERGENiHBG001525.
    InParanoidiO15235.
    KOiK02950.
    OrthoDBiEOG7Z69F2.
    PhylomeDBiO15235.
    TreeFamiTF315095.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR006032. Ribosomal_S12/S23.
    IPR005679. Ribosomal_S12_bac.
    [Graphical view]
    PANTHERiPTHR11652. PTHR11652. 1 hit.
    PfamiPF00164. Ribosom_S12_S23. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
    PRINTSiPR01034. RIBOSOMALS12.
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
    PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O15235-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWSGLLHGL NTSLTCGPAL VPRLWATCSM ATLNQMHRLG PPKRPPRKLG    50
    PTEGRPQLKG VVLCTFTRKP KKPNSANRKC CRVRLSTGRE AVCFIPGEGH 100
    TLQEHQIVLV EGGRTQDLPG VKLTVVRGKY DCGHVQKK 138
    Length:138
    Mass (Da):15,173
    Last modified:January 1, 1998 - v1
    Checksum:i893FD2CA1C7187A7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti8 – 81H → R.
    Corresponds to variant rs33988199 [ dbSNP | Ensembl ].
    VAR_051820

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11681 mRNA. Translation: CAA72377.1.
    AF058761 Genomic DNA. Translation: AAC64704.1.
    CR407609 mRNA. Translation: CAG28537.1.
    CH471126 Genomic DNA. Translation: EAW56849.1.
    BC001617 mRNA. Translation: AAH01617.1.
    BC006424 mRNA. Translation: AAH06424.1.
    BC007499 mRNA. Translation: AAH07499.1.
    CCDSiCCDS12525.1.
    RefSeqiNP_066930.1. NM_021107.1.
    NP_203526.1. NM_033362.3.
    NP_203527.1. NM_033363.1.
    UniGeneiHs.411125.

    Genome annotation databases

    EnsembliENST00000308018; ENSP00000308845; ENSG00000128626.
    ENST00000402029; ENSP00000384579; ENSG00000128626.
    ENST00000407800; ENSP00000384952; ENSG00000128626.
    GeneIDi6183.
    KEGGihsa:6183.
    UCSCiuc002okc.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11681 mRNA. Translation: CAA72377.1 .
    AF058761 Genomic DNA. Translation: AAC64704.1 .
    CR407609 mRNA. Translation: CAG28537.1 .
    CH471126 Genomic DNA. Translation: EAW56849.1 .
    BC001617 mRNA. Translation: AAH01617.1 .
    BC006424 mRNA. Translation: AAH06424.1 .
    BC007499 mRNA. Translation: AAH07499.1 .
    CCDSi CCDS12525.1.
    RefSeqi NP_066930.1. NM_021107.1.
    NP_203526.1. NM_033362.3.
    NP_203527.1. NM_033363.1.
    UniGenei Hs.411125.

    3D structure databases

    ProteinModelPortali O15235.
    SMRi O15235. Positions 53-138.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112098. 7 interactions.
    IntActi O15235. 5 interactions.
    MINTi MINT-1373561.
    STRINGi 9606.ENSP00000308845.

    PTM databases

    PhosphoSitei O15235.

    Proteomic databases

    MaxQBi O15235.
    PaxDbi O15235.
    PeptideAtlasi O15235.
    PRIDEi O15235.

    Protocols and materials databases

    DNASUi 6183.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308018 ; ENSP00000308845 ; ENSG00000128626 .
    ENST00000402029 ; ENSP00000384579 ; ENSG00000128626 .
    ENST00000407800 ; ENSP00000384952 ; ENSG00000128626 .
    GeneIDi 6183.
    KEGGi hsa:6183.
    UCSCi uc002okc.3. human.

    Organism-specific databases

    CTDi 6183.
    GeneCardsi GC19P039422.
    HGNCi HGNC:10380. MRPS12.
    HPAi HPA046775.
    HPA050633.
    MIMi 603021. gene.
    neXtProti NX_O15235.
    PharmGKBi PA30996.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0048.
    HOGENOMi HOG000040063.
    HOVERGENi HBG001525.
    InParanoidi O15235.
    KOi K02950.
    OrthoDBi EOG7Z69F2.
    PhylomeDBi O15235.
    TreeFami TF315095.

    Miscellaneous databases

    GeneWikii MRPS12.
    GenomeRNAii 6183.
    NextBioi 24009.
    PROi O15235.
    SOURCEi Search...

    Gene expression databases

    Bgeei O15235.
    CleanExi HS_MRPS12.
    Genevestigatori O15235.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR006032. Ribosomal_S12/S23.
    IPR005679. Ribosomal_S12_bac.
    [Graphical view ]
    PANTHERi PTHR11652. PTHR11652. 1 hit.
    Pfami PF00164. Ribosom_S12_S23. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002133. Ribosomal_S12/S23. 1 hit.
    PRINTSi PR01034. RIBOSOMALS12.
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00981. rpsL_bact. 1 hit.
    PROSITEi PS00055. RIBOSOMAL_S12. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Metazoan nuclear genes for mitoribosomal protein S12."
      Shah Z.H., O'Dell K.M., Miller S.C.M., An X., Jacobs H.T.
      Gene 204:55-62(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Characterization of the human mitochondrial ribosomal S12 gene."
      Johnson D.F., Hamon M., Fischel-Ghodsian N.
      Genomics 52:363-368(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Colon and Skin.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRT12_HUMAN
    AccessioniPrimary (citable) accession number: O15235
    Secondary accession number(s): Q53X98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3