O15235 (RT12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S12, mitochondrial
Short name=MRP-S12
Short name=S12mt

Alternative name(s):
MT-RPS12

Gene names

Name:	MRPS12
Synonyms:	RPMS12, RPSM12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the ribosomal protein S12P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial ribosome Traceable author statement PubMed 9545647. Source: ProtInc small ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular_function	structural constituent of ribosome Traceable author statement PubMed 9545647. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SPINK7	P58062	3	EBI-712205,EBI-1182445

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 29	29	Mitochondrion Potential
	Chain	30 – 138	109	28S ribosomal protein S12, mitochondrial		PRO_0000030606
Natural variations
	Natural variant	8	1	H → R. Corresponds to variant rs33988199 [ dbSNP | Ensembl ].		VAR_051820

Sequences

	Sequence		Length	Mass (Da)
	O15235 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 893FD2CA1C7187A7	FASTA	138	15,173
	10 20 30 40 50 60 MSWSGLLHGL NTSLTCGPAL VPRLWATCSM ATLNQMHRLG PPKRPPRKLG PTEGRPQLKG 70 80 90 100 110 120 VVLCTFTRKP KKPNSANRKC CRVRLSTGRE AVCFIPGEGH TLQEHQIVLV EGGRTQDLPG 130 VKLTVVRGKY DCGHVQKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Metazoan nuclear genes for mitoribosomal protein S12." Shah Z.H., O'Dell K.M., Miller S.C.M., An X., Jacobs H.T. Gene 204:55-62(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Characterization of the human mitochondrial ribosomal S12 gene." Johnson D.F., Hamon M., Fischel-Ghodsian N. Genomics 52:363-368(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Colon and Skin.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y11681 mRNA. Translation: CAA72377.1. AF058761 Genomic DNA. Translation: AAC64704.1. CR407609 mRNA. Translation: CAG28537.1. CH471126 Genomic DNA. Translation: EAW56849.1. BC001617 mRNA. Translation: AAH01617.1. BC006424 mRNA. Translation: AAH06424.1. BC007499 mRNA. Translation: AAH07499.1.
IPI	IPI00005692.
RefSeq	NP_066930.1. NM_021107.1. NP_203526.1. NM_033362.3. NP_203527.1. NM_033363.1.
UniGene	Hs.411125.
3D structure databases
ProteinModelPortal	O15235.
ModBase	Search...
Protein-protein interaction databases
IntAct	O15235. 5 interactions.
MINT	MINT-1373561.
STRING	9606.ENSP00000308845.
PTM databases
PhosphoSite	O15235.
Proteomic databases
PaxDb	O15235.
PeptideAtlas	O15235.
PRIDE	O15235.
Protocols and materials databases
DNASU	6183.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308018; ENSP00000308845; ENSG00000128626. ENST00000402029; ENSP00000384579; ENSG00000128626. ENST00000407800; ENSP00000384952; ENSG00000128626.
GeneID	6183.
KEGG	hsa:6183.
UCSC	uc002okc.3. human.
Organism-specific databases
CTD	6183.
GeneCards	GC19P039422.
HGNC	HGNC:10380. MRPS12.
HPA	HPA046775. HPA050633.
MIM	603021. gene.
neXtProt	NX_O15235.
PharmGKB	PA30996.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0048.
HOGENOM	HOG000040063.
HOVERGEN	HBG001525.
InParanoid	O15235.
KO	K02950.
OMA	LNQMHRQ.
OrthoDB	EOG4MGS8W.
PhylomeDB	O15235.
Gene expression databases
Bgee	O15235.
CleanEx	HS_MRPS12.
Genevestigator	O15235.
GermOnline	ENSG00000128626. Homo sapiens.
Family and domain databases
Gene3D	2.40.50.140. 1 hit.
InterPro	IPR012340. NA-bd_OB-fold. IPR006032. Ribosomal_S12/S23. IPR005679. Ribosomal_S12_bac. [Graphical view]
PANTHER	PTHR11652. PTHR11652. 1 hit.
Pfam	PF00164. Ribosomal_S12. 1 hit. [Graphical view]
PIRSF	PIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTS	PR01034. RIBOSOMALS12.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMs	TIGR00981. rpsL_bact. 1 hit.
PROSITE	PS00055. RIBOSOMAL_S12. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6183.
NextBio	24009.
SOURCE	Search...

Entry information

Entry name

RT12_HUMAN

Accession

Primary (citable) accession number: O15235
Secondary accession number(s): Q53X98

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.