Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 185

Gene

ZNF185

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of cellular proliferation and/or differentiation.

GO - Molecular functioni

  • zinc ion binding Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147394-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 185
Alternative name(s):
LIM domain protein ZNF185
P1-A
Gene namesi
Name:ZNF185
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:12976. ZNF185.

Subcellular locationi

  • Cytoplasmcytoskeleton 1 Publication
  • Cell junctionfocal adhesion 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi7739.
OpenTargetsiENSG00000147394.
PharmGKBiPA37558.

Polymorphism and mutation databases

BioMutaiZNF185.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759111 – 689Zinc finger protein 185Add BLAST689

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei153PhosphoserineBy similarity1
Modified residuei447PhosphothreonineCombined sources1
Modified residuei453PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Isoform 2 (identifier: O15231-2)
Modified residuei66PhosphoserineCombined sources1
Isoform 3 (identifier: O15231-3)
Modified residuei206PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15231.
MaxQBiO15231.
PeptideAtlasiO15231.
PRIDEiO15231.

PTM databases

iPTMnetiO15231.
PhosphoSitePlusiO15231.

Expressioni

Tissue specificityi

Expressed in placenta, pancreas and kidney. Also expressed in prostate, testis, ovary and blood.

Gene expression databases

BgeeiENSG00000147394.
CleanExiHS_ZNF185.
ExpressionAtlasiO15231. baseline and differential.
GenevisibleiO15231. HS.

Organism-specific databases

HPAiHPA000400.
HPA016438.

Interactioni

Protein-protein interaction databases

BioGridi113525. 2 interactors.
IntActiO15231. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliO15231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini627 – 689LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi159 – 165Poly-Glu7

Sequence similaritiesi

Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain

Phylogenomic databases

GeneTreeiENSGT00530000063872.
HOGENOMiHOG000232182.
HOVERGENiHBG071794.
InParanoidiO15231.
OMAiEQPHVYI.
OrthoDBiEOG091G09RH.
PhylomeDBiO15231.
TreeFamiTF335114.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR001781. Znf_LIM.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15231-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSISALGGRT KGKPLPPGEE ERNNVLKQMK VRTTLKGDKS WITKQDESEG
60 70 80 90 100
RTIELPSGRS RATSFSSAGE VPKPRPPSTR APTGYIIRGV FTKPIDSSSQ
110 120 130 140 150
PQQQFPKANG TPKSAASLVR TANAGPPRPS SSGYKMTTED YKKLAPYNIR
160 170 180 190 200
RSSTSGDTEE EEEEEVVPFS SDEQKRRSEA ASGVLRRTAP REHSYVLSAA
210 220 230 240 250
KKSTGPTQET QAPFIAKRVE VVEEDGPSEK SQDPPALARS TPGSNSADGG
260 270 280 290 300
RTKASRAIWI ECLPSMPSPA GSQELSSRGE EIVRLQILTP RAGLRLVAPD
310 320 330 340 350
VEGMRSSPGN KDKEAPCSRE LQRDLAGEEA FRAPNTDAAR SSAQLSDGNV
360 370 380 390 400
GSGATGSRPE GLAAVDIGSE RGSSSATSVS AVPADRKSNS TAAQEDAKAD
410 420 430 440 450
PKGALADYEG KDVATRVGEA WQERPGAPRG GQGDPAVPAQ QPADPSTPER
460 470 480 490 500
QSSPSGSEQL VRRESCGSSV LTDFEGKDVA TKVGEAWQDR PGAPRGGQGD
510 520 530 540 550
PAVPTQQPAD PSTPEQQNSP SGSEQFVRRE SCTSRVRSPS SCMVTVTVTA
560 570 580 590 600
TSEQPHIYIP APASELDSSS TTKGILFVKE YVNASEVSSG KPVSARYSNV
610 620 630 640 650
SSIEDSFAME KKPPCGSTPY SERTTGGICT YCNREIRDCP KITLEHLGIC
660 670 680
CHEYCFKCGI CSKPMGDLLD QIFIHRDTIH CGKCYEKLF
Length:689
Mass (Da):73,525
Last modified:October 5, 2010 - v3
Checksum:i0CCA739701FE1423
GO
Isoform 2 (identifier: O15231-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-140: Missing.
     141-144: YKKL → MQRQ
     205-205: G → GS
     246-275: Missing.
     305-372: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:452
Mass (Da):48,621
Checksum:i9B4871D31EEEE57C
GO
Isoform 3 (identifier: O15231-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-205: G → GS

Show »
Length:690
Mass (Da):73,613
Checksum:i7E7AFDCFF902FE68
GO
Isoform 4 (identifier: O15231-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     246-304: Missing.

Show »
Length:630
Mass (Da):67,281
Checksum:i63CC539EF52C25A5
GO
Isoform 5 (identifier: O15231-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.
     177-205: RSEAASGVLRRTAPREHSYVLSAAKKSTG → SS
     246-304: Missing.

Note: No experimental confirmation available.
Show »
Length:468
Mass (Da):49,972
Checksum:i530D1C7F62C34557
GO
Isoform 6 (identifier: O15231-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     372-372: G → GRLCAAASFASFLEDQDGHSANSQSCKPRPAAI

Show »
Length:721
Mass (Da):76,857
Checksum:i177A88C27289F3A6
GO
Isoform 7 (identifier: O15231-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-304: Missing.

Show »
Length:660
Mass (Da):70,380
Checksum:i373470CD29FE5785
GO
Isoform 8 (identifier: O15231-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-304: Missing.
     372-372: G → GRLCAAASFASFLEDQDGHSANSQSCKPRPAAI

Show »
Length:692
Mass (Da):73,711
Checksum:i38B94FB3CEF11C3E
GO
Isoform 9 (identifier: O15231-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-403: MSISALGGRT...QEDAKADPKG → MAARDELGLG...PEELAAPSPA

Note: No experimental confirmation available.
Show »
Length:327
Mass (Da):34,954
Checksum:iCCAF1D825E0F9C1B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13K → E in ABF57661 (PubMed:16799630).Curated1
Sequence conflicti132S → F in ABF57661 (PubMed:16799630).Curated1
Sequence conflicti150R → G in ABF57661 (PubMed:16799630).Curated1
Sequence conflicti236A → V in BAH13507 (PubMed:14702039).Curated1
Sequence conflicti257A → T in ABF57661 (PubMed:16799630).Curated1
Sequence conflicti326A → S in BAH13507 (PubMed:14702039).Curated1
Sequence conflicti406A → D in ABF57661 (PubMed:16799630).Curated1
Sequence conflicti408Y → C in CAA70733 (PubMed:9268636).Curated1
Sequence conflicti414A → P in ABF57657 (PubMed:16799630).Curated1
Sequence conflicti414A → P in AAY54245 (PubMed:16799630).Curated1
Sequence conflicti414A → P in CAA70733 (PubMed:9268636).Curated1
Sequence conflicti488Q → H in ABF57660 (PubMed:16799630).Curated1
Sequence conflicti492G → R in CAA70733 (PubMed:9268636).Curated1
Sequence conflicti517Q → R in BAC04511 (PubMed:14702039).Curated1
Sequence conflicti621S → F in ABF57657 (PubMed:16799630).Curated1
Sequence conflicti621S → F in AAY54245 (PubMed:16799630).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0547731 – 403MSISA…ADPKG → MAARDELGLGGDSLEAMPVP AARGRPRITNGPEELAAPSP A in isoform 9. 1 PublicationAdd BLAST403
Alternative sequenceiVSP_0398981 – 140Missing in isoform 2. 1 PublicationAdd BLAST140
Alternative sequenceiVSP_0450801 – 135Missing in isoform 5. 1 PublicationAdd BLAST135
Alternative sequenceiVSP_039899141 – 144YKKL → MQRQ in isoform 2. 1 Publication4
Alternative sequenceiVSP_045081177 – 205RSEAA…KKSTG → SS in isoform 5. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_039900205G → GS in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_043405246 – 304Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST59
Alternative sequenceiVSP_039901246 – 275Missing in isoform 2. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_047205276 – 304Missing in isoform 7 and isoform 8. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_039902305 – 372Missing in isoform 2. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_047206372G → GRLCAAASFASFLEDQDGHS ANSQSCKPRPAAI in isoform 6 and isoform 8. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095258 mRNA. Translation: BAC04511.1.
AY997296 mRNA. Translation: AAY54245.1.
DQ508022 mRNA. Translation: ABF57657.1.
DQ508023 mRNA. Translation: ABF57658.1.
DQ508024 mRNA. Translation: ABF57659.1.
DQ508025 mRNA. Translation: ABF57660.1.
DQ508026 mRNA. Translation: ABF57661.1.
Y09538 mRNA. Translation: CAA70733.1.
AK296967 mRNA. Translation: BAG59511.1.
AK301530 mRNA. Translation: BAH13507.1.
U82671 Genomic DNA. No translation available.
CH471172 Genomic DNA. Translation: EAW72895.1.
CCDSiCCDS48184.1. [O15231-1]
CCDS55528.1. [O15231-3]
CCDS55529.1. [O15231-6]
CCDS55530.1. [O15231-8]
CCDS55531.1. [O15231-4]
CCDS55532.1. [O15231-5]
CCDS69832.1. [O15231-9]
RefSeqiNP_001171577.1. NM_001178106.1. [O15231-6]
NP_001171578.1. NM_001178107.1. [O15231-8]
NP_001171579.1. NM_001178108.1. [O15231-3]
NP_001171580.1. NM_001178109.1. [O15231-7]
NP_001171581.1. NM_001178110.1. [O15231-4]
NP_001171584.1. NM_001178113.1. [O15231-5]
NP_001171586.1. NM_001178115.1. [O15231-9]
NP_009081.2. NM_007150.3. [O15231-1]
XP_005274788.1. XM_005274731.2. [O15231-6]
XP_005274792.1. XM_005274735.2. [O15231-8]
XP_005274794.1. XM_005274737.2. [O15231-3]
XP_005274795.1. XM_005274738.2. [O15231-1]
XP_005274798.1. XM_005274741.2. [O15231-7]
XP_005274802.1. XM_005274745.2. [O15231-4]
UniGeneiHs.16622.

Genome annotation databases

EnsembliENST00000318504; ENSP00000312782; ENSG00000147394. [O15231-4]
ENST00000318529; ENSP00000313919; ENSG00000147394. [O15231-5]
ENST00000324823; ENSP00000325307; ENSG00000147394. [O15231-2]
ENST00000370268; ENSP00000359291; ENSG00000147394. [O15231-1]
ENST00000370270; ENSP00000359293; ENSG00000147394. [O15231-6]
ENST00000449285; ENSP00000395228; ENSG00000147394. [O15231-3]
ENST00000454925; ENSP00000392984; ENSG00000147394. [O15231-9]
ENST00000535861; ENSP00000440847; ENSG00000147394. [O15231-6]
ENST00000539731; ENSP00000444367; ENSG00000147394. [O15231-8]
GeneIDi7739.
KEGGihsa:7739.
UCSCiuc004fgw.5. human. [O15231-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095258 mRNA. Translation: BAC04511.1.
AY997296 mRNA. Translation: AAY54245.1.
DQ508022 mRNA. Translation: ABF57657.1.
DQ508023 mRNA. Translation: ABF57658.1.
DQ508024 mRNA. Translation: ABF57659.1.
DQ508025 mRNA. Translation: ABF57660.1.
DQ508026 mRNA. Translation: ABF57661.1.
Y09538 mRNA. Translation: CAA70733.1.
AK296967 mRNA. Translation: BAG59511.1.
AK301530 mRNA. Translation: BAH13507.1.
U82671 Genomic DNA. No translation available.
CH471172 Genomic DNA. Translation: EAW72895.1.
CCDSiCCDS48184.1. [O15231-1]
CCDS55528.1. [O15231-3]
CCDS55529.1. [O15231-6]
CCDS55530.1. [O15231-8]
CCDS55531.1. [O15231-4]
CCDS55532.1. [O15231-5]
CCDS69832.1. [O15231-9]
RefSeqiNP_001171577.1. NM_001178106.1. [O15231-6]
NP_001171578.1. NM_001178107.1. [O15231-8]
NP_001171579.1. NM_001178108.1. [O15231-3]
NP_001171580.1. NM_001178109.1. [O15231-7]
NP_001171581.1. NM_001178110.1. [O15231-4]
NP_001171584.1. NM_001178113.1. [O15231-5]
NP_001171586.1. NM_001178115.1. [O15231-9]
NP_009081.2. NM_007150.3. [O15231-1]
XP_005274788.1. XM_005274731.2. [O15231-6]
XP_005274792.1. XM_005274735.2. [O15231-8]
XP_005274794.1. XM_005274737.2. [O15231-3]
XP_005274795.1. XM_005274738.2. [O15231-1]
XP_005274798.1. XM_005274741.2. [O15231-7]
XP_005274802.1. XM_005274745.2. [O15231-4]
UniGeneiHs.16622.

3D structure databases

ProteinModelPortaliO15231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113525. 2 interactors.
IntActiO15231. 2 interactors.

PTM databases

iPTMnetiO15231.
PhosphoSitePlusiO15231.

Polymorphism and mutation databases

BioMutaiZNF185.

Proteomic databases

EPDiO15231.
MaxQBiO15231.
PeptideAtlasiO15231.
PRIDEiO15231.

Protocols and materials databases

DNASUi7739.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318504; ENSP00000312782; ENSG00000147394. [O15231-4]
ENST00000318529; ENSP00000313919; ENSG00000147394. [O15231-5]
ENST00000324823; ENSP00000325307; ENSG00000147394. [O15231-2]
ENST00000370268; ENSP00000359291; ENSG00000147394. [O15231-1]
ENST00000370270; ENSP00000359293; ENSG00000147394. [O15231-6]
ENST00000449285; ENSP00000395228; ENSG00000147394. [O15231-3]
ENST00000454925; ENSP00000392984; ENSG00000147394. [O15231-9]
ENST00000535861; ENSP00000440847; ENSG00000147394. [O15231-6]
ENST00000539731; ENSP00000444367; ENSG00000147394. [O15231-8]
GeneIDi7739.
KEGGihsa:7739.
UCSCiuc004fgw.5. human. [O15231-1]

Organism-specific databases

CTDi7739.
DisGeNETi7739.
GeneCardsiZNF185.
HGNCiHGNC:12976. ZNF185.
HPAiHPA000400.
HPA016438.
MIMi300381. gene.
neXtProtiNX_O15231.
OpenTargetsiENSG00000147394.
PharmGKBiPA37558.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063872.
HOGENOMiHOG000232182.
HOVERGENiHBG071794.
InParanoidiO15231.
OMAiEQPHVYI.
OrthoDBiEOG091G09RH.
PhylomeDBiO15231.
TreeFamiTF335114.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147394-MONOMER.

Miscellaneous databases

ChiTaRSiZNF185. human.
GenomeRNAii7739.
PROiO15231.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147394.
CleanExiHS_ZNF185.
ExpressionAtlasiO15231. baseline and differential.
GenevisibleiO15231. HS.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR001781. Znf_LIM.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN185_HUMAN
AccessioniPrimary (citable) accession number: O15231
Secondary accession number(s): A4FTV3
, A6NME5, B4DLE9, B7Z771, B8K2L9, B8K2M0, B8K2M1, B8K2M2, E9PFR6, F5GXF7, F5GZL4, F8W8V7, H0Y4M8, O00345, Q8N1R8, Q9NSD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.