ID   GP182_HUMAN             Reviewed;         404 AA.
AC   O15218;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   24-JAN-2024, entry version 174.
DE   RecName: Full=G-protein coupled receptor 182;
GN   Name=GPR182; Synonyms=ADMR;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=9367907; DOI=10.1006/bbrc.1997.7631;
RA   Haenze J., Dittrich K., Dotsch J., Rascher W.;
RT   "Molecular cloning of a novel human receptor gene with homology to the rat
RT   adrenomedullin receptor and high expression in heart and immune system.";
RL   Biochem. Biophys. Res. Commun. 240:183-188(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT   "cDNA clones of human proteins involved in signal transduction sequenced by
RT   the Guthrie cDNA resource center (www.cdna.org).";
RL   Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   DOUBTS ON THE ORIGINAL FUNCTION.
RX   PubMed=9535752; DOI=10.1006/bbrc.1998.8349;
RA   Kennedy S.P., Sun D., Oleynek J.J., Hoth C.F., Kong J., Hill R.J.;
RT   "Expression of the rat adrenomedullin receptor or a putative human
RT   adrenomedullin receptor does not correlate with adrenomedullin binding or
RT   functional response.";
RL   Biochem. Biophys. Res. Commun. 244:832-837(1998).
CC   -!- FUNCTION: Orphan receptor.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, immune
CC       system, adrenal gland and liver. {ECO:0000269|PubMed:9367907}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- CAUTION: Was originally thought to be a receptor for adrenomedullin.
CC       {ECO:0000305|PubMed:9367907}.
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DR   EMBL; Y13583; CAA73910.1; -; mRNA.
DR   EMBL; AY268434; AAP23201.1; -; Genomic_DNA.
DR   EMBL; BC034761; AAH34761.1; -; mRNA.
DR   CCDS; CCDS8927.1; -.
DR   PIR; JC5784; JC5784.
DR   RefSeq; NP_009195.1; NM_007264.3.
DR   RefSeq; XP_011536126.1; XM_011537824.2.
DR   RefSeq; XP_011536127.1; XM_011537825.2.
DR   RefSeq; XP_011536129.1; XM_011537827.2.
DR   AlphaFoldDB; O15218; -.
DR   SMR; O15218; -.
DR   BioGRID; 116449; 502.
DR   IntAct; O15218; 10.
DR   MINT; O15218; -.
DR   STRING; 9606.ENSP00000300098; -.
DR   ChEMBL; CHEMBL4356; -.
DR   GlyCosmos; O15218; 2 sites, No reported glycans.
DR   GlyGen; O15218; 2 sites.
DR   PhosphoSitePlus; O15218; -.
DR   BioMuta; GPR182; -.
DR   MassIVE; O15218; -.
DR   PaxDb; 9606-ENSP00000300098; -.
DR   PeptideAtlas; O15218; -.
DR   ProteomicsDB; 48515; -.
DR   Antibodypedia; 16024; 319 antibodies from 32 providers.
DR   DNASU; 11318; -.
DR   Ensembl; ENST00000300098.3; ENSP00000300098.1; ENSG00000166856.3.
DR   GeneID; 11318; -.
DR   KEGG; hsa:11318; -.
DR   MANE-Select; ENST00000300098.3; ENSP00000300098.1; NM_007264.4; NP_009195.1.
DR   UCSC; uc001smk.4; human.
DR   AGR; HGNC:13708; -.
DR   CTD; 11318; -.
DR   DisGeNET; 11318; -.
DR   GeneCards; GPR182; -.
DR   HGNC; HGNC:13708; GPR182.
DR   HPA; ENSG00000166856; Tissue enhanced (lymphoid tissue, testis).
DR   MIM; 605307; gene.
DR   neXtProt; NX_O15218; -.
DR   OpenTargets; ENSG00000166856; -.
DR   PharmGKB; PA162390165; -.
DR   VEuPathDB; HostDB:ENSG00000166856; -.
DR   eggNOG; ENOG502QSNU; Eukaryota.
DR   GeneTree; ENSGT00940000154307; -.
DR   HOGENOM; CLU_009579_8_3_1; -.
DR   InParanoid; O15218; -.
DR   OMA; LYFFNHT; -.
DR   OrthoDB; 3977704at2759; -.
DR   PhylomeDB; O15218; -.
DR   TreeFam; TF333489; -.
DR   PathwayCommons; O15218; -.
DR   SignaLink; O15218; -.
DR   BioGRID-ORCS; 11318; 25 hits in 1147 CRISPR screens.
DR   GeneWiki; GPR182; -.
DR   GenomeRNAi; 11318; -.
DR   Pharos; O15218; Tbio.
DR   PRO; PR:O15218; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; O15218; Protein.
DR   Bgee; ENSG00000166856; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 98 other cell types or tissues.
DR   ExpressionAtlas; O15218; baseline and differential.
DR   GO; GO:0016020; C:membrane; TAS:ProtInc.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
DR   CDD; cd14988; 7tmA_GPR182; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR001350; G10D_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR047143; GPER1-like.
DR   PANTHER; PTHR24226:SF0; G-PROTEIN COUPLED RECEPTOR 182; 1.
DR   PANTHER; PTHR24226; G-PROTEIN COUPLED RECEPTOR 182 AND ESTROGEN RECEPTOR 1; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00643; G10DORPHANR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; O15218; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..404
FT                   /note="G-protein coupled receptor 182"
FT                   /id="PRO_0000069112"
FT   TOPO_DOM        1..57
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..90
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..113
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        114..127
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..149
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        150..170
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..193
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        194..217
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..239
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        240..258
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..280
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        281..299
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        321..404
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        28
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        37
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        126..202
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         349
FT                   /note="C -> R (in dbSNP:rs35493121)"
FT                   /id="VAR_033464"
SQ   SEQUENCE   404 AA;  45323 MW;  EF187ECFDF2DC6C1 CRC64;
     MSVKPSWGPG PSEGVTAVPT SDLGEIHNWT ELLDLFNHTL SECHVELSQS TKRVVLFALY
     LAMFVVGLVE NLLVICVNWR GSGRAGLMNL YILNMAIADL GIVLSLPVWM LEVTLDYTWL
     WGSFSCRFTH YFYFVNMYSS IFFLVCLSVD RYVTLTSASP SWQRYQHRVR RAMCAGIWVL
     SAIIPLPEVV HIQLVEGPEP MCLFMAPFET YSTWALAVAL STTILGFLLP FPLITVFNVL
     TACRLRQPGQ PKSRRHCLLL CAYVAVFVMC WLPYHVTLLL LTLHGTHISL HCHLVHLLYF
     FYDVIDCFSM LHCVINPILY NFLSPHFRGR LLNAVVHYLP KDQTKAGTCA SSSSCSTQHS
     IIITKGDSQP AAAAPHPEPS LSFQAHHLLP NTSPISPTQP LTPS
//