O15218 (GP182_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G-protein coupled receptor 182

Gene names

Name:	GPR182
Synonyms:	ADMR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor. Ref.4
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in heart, skeletal muscle, immune system, adrenal gland and liver. Ref.1
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	Was originally (Ref.1) thought to be a receptor for adrenomedullin.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell surface receptor signaling pathway Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to membrane Traceable author statement Ref.1. Source: ProtInc plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW transmembrane signaling receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	G-protein coupled receptor 182		PRO_0000069112
Regions
	Topological domain	1 – 57	57	Extracellular Potential
	Transmembrane	58 – 79	22	Helical; Name=1; Potential
	Topological domain	80 – 90	11	Cytoplasmic Potential
	Transmembrane	91 – 113	23	Helical; Name=2; Potential
	Topological domain	114 – 127	14	Extracellular Potential
	Transmembrane	128 – 149	22	Helical; Name=3; Potential
	Topological domain	150 – 170	21	Cytoplasmic Potential
	Transmembrane	171 – 193	23	Helical; Name=4; Potential
	Topological domain	194 – 217	24	Extracellular Potential
	Transmembrane	218 – 239	22	Helical; Name=5; Potential
	Topological domain	240 – 258	19	Cytoplasmic Potential
	Transmembrane	259 – 280	22	Helical; Name=6; Potential
	Topological domain	281 – 299	19	Extracellular Potential
	Transmembrane	300 – 320	21	Helical; Name=7; Potential
	Topological domain	321 – 404	84	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	28	1	N-linked (GlcNAc...) Potential
	Glycosylation	37	1	N-linked (GlcNAc...) Potential
	Disulfide bond	126 ↔ 202		By similarity
Natural variations
	Natural variant	349	1	C → R. Corresponds to variant rs35493121 [ dbSNP | Ensembl ].		VAR_033464

Sequences

	Sequence		Length	Mass (Da)
	O15218 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: EF187ECFDF2DC6C1	FASTA	404	45,323
	10 20 30 40 50 60 MSVKPSWGPG PSEGVTAVPT SDLGEIHNWT ELLDLFNHTL SECHVELSQS TKRVVLFALY 70 80 90 100 110 120 LAMFVVGLVE NLLVICVNWR GSGRAGLMNL YILNMAIADL GIVLSLPVWM LEVTLDYTWL 130 140 150 160 170 180 WGSFSCRFTH YFYFVNMYSS IFFLVCLSVD RYVTLTSASP SWQRYQHRVR RAMCAGIWVL 190 200 210 220 230 240 SAIIPLPEVV HIQLVEGPEP MCLFMAPFET YSTWALAVAL STTILGFLLP FPLITVFNVL 250 260 270 280 290 300 TACRLRQPGQ PKSRRHCLLL CAYVAVFVMC WLPYHVTLLL LTLHGTHISL HCHLVHLLYF 310 320 330 340 350 360 FYDVIDCFSM LHCVINPILY NFLSPHFRGR LLNAVVHYLP KDQTKAGTCA SSSSCSTQHS 370 380 390 400 IIITKGDSQP AAAAPHPEPS LSFQAHHLLP NTSPISPTQP LTPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system." Haenze J., Dittrich K., Dotsch J., Rascher W. Biochem. Biophys. Res. Commun. 240:183-188(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[4]	"Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response." Kennedy S.P., Sun D., Oleynek J.J., Hoth C.F., Kong J., Hill R.J. Biochem. Biophys. Res. Commun. 244:832-837(1998) [PubMed] [Europe PMC] [Abstract] Cited for: DOUBTS ON THE ORIGINAL FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y13583 mRNA. Translation: CAA73910.1. AY268434 Genomic DNA. Translation: AAP23201.1. BC034761 mRNA. Translation: AAH34761.1.
IPI	IPI00005660.
PIR	JC5784.
RefSeq	NP_009195.1. NM_007264.3.
UniGene	Hs.483909.
3D structure databases
ProteinModelPortal	O15218.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000300098.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O15218.
Proteomic databases
PRIDE	O15218.
Protocols and materials databases
DNASU	11318.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300098; ENSP00000300098; ENSG00000166856.
GeneID	11318.
KEGG	hsa:11318.
UCSC	uc001smk.3. human.
Organism-specific databases
CTD	11318.
GeneCards	GC12P057388.
HGNC	HGNC:13708. GPR182.
HPA	HPA027037.
MIM	605307. gene.
neXtProt	NX_O15218.
PharmGKB	PA162390165.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG147624.
HOGENOM	HOG000220818.
HOVERGEN	HBG097691.
InParanoid	O15218.
KO	K04242.
OMA	FANMYSS.
OrthoDB	EOG451DRM.
PhylomeDB	O15218.
Gene expression databases
Bgee	O15218.
CleanEx	HS_GPR182.
Genevestigator	O15218.
GermOnline	ENSG00000166856. Homo sapiens.
Family and domain databases
InterPro	IPR001350. G10D_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00643. G10DORPHANR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL4356.
GenomeRNAi	11318.
NextBio	42999.
SOURCE	Search...

Entry information

Entry name

GP182_HUMAN

Accession

Primary (citable) accession number: O15218

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.