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O15218 (GP182_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G-protein coupled receptor 182
Gene names
Name:GPR182
Synonyms:ADMR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in heart, skeletal muscle, immune system, adrenal gland and liver. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

Was originally (Ref.1) thought to be a receptor for adrenomedullin.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404G-protein coupled receptor 182
PRO_0000069112

Regions

Topological domain1 – 5757Extracellular Potential
Transmembrane58 – 7922Helical; Name=1; Potential
Topological domain80 – 9011Cytoplasmic Potential
Transmembrane91 – 11323Helical; Name=2; Potential
Topological domain114 – 12714Extracellular Potential
Transmembrane128 – 14922Helical; Name=3; Potential
Topological domain150 – 17021Cytoplasmic Potential
Transmembrane171 – 19323Helical; Name=4; Potential
Topological domain194 – 21724Extracellular Potential
Transmembrane218 – 23922Helical; Name=5; Potential
Topological domain240 – 25819Cytoplasmic Potential
Transmembrane259 – 28022Helical; Name=6; Potential
Topological domain281 – 29919Extracellular Potential
Transmembrane300 – 32021Helical; Name=7; Potential
Topological domain321 – 40484Cytoplasmic Potential

Amino acid modifications

Glycosylation281N-linked (GlcNAc...) Potential
Glycosylation371N-linked (GlcNAc...) Potential
Disulfide bond126 ↔ 202 By similarity

Natural variations

Natural variant3491C → R.
Corresponds to variant rs35493121 [ dbSNP | Ensembl ].
VAR_033464

Sequences

Sequence LengthMass (Da)Tools
O15218 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: EF187ECFDF2DC6C1

FASTA40445,323
        10         20         30         40         50         60 
MSVKPSWGPG PSEGVTAVPT SDLGEIHNWT ELLDLFNHTL SECHVELSQS TKRVVLFALY 

        70         80         90        100        110        120 
LAMFVVGLVE NLLVICVNWR GSGRAGLMNL YILNMAIADL GIVLSLPVWM LEVTLDYTWL 

       130        140        150        160        170        180 
WGSFSCRFTH YFYFVNMYSS IFFLVCLSVD RYVTLTSASP SWQRYQHRVR RAMCAGIWVL 

       190        200        210        220        230        240 
SAIIPLPEVV HIQLVEGPEP MCLFMAPFET YSTWALAVAL STTILGFLLP FPLITVFNVL 

       250        260        270        280        290        300 
TACRLRQPGQ PKSRRHCLLL CAYVAVFVMC WLPYHVTLLL LTLHGTHISL HCHLVHLLYF 

       310        320        330        340        350        360 
FYDVIDCFSM LHCVINPILY NFLSPHFRGR LLNAVVHYLP KDQTKAGTCA SSSSCSTQHS 

       370        380        390        400 
IIITKGDSQP AAAAPHPEPS LSFQAHHLLP NTSPISPTQP LTPS 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system."
Haenze J., Dittrich K., Dotsch J., Rascher W.
Biochem. Biophys. Res. Commun. 240:183-188(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[4]"Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response."
Kennedy S.P., Sun D., Oleynek J.J., Hoth C.F., Kong J., Hill R.J.
Biochem. Biophys. Res. Commun. 244:832-837(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: DOUBTS ON THE ORIGINAL FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y13583 mRNA. Translation: CAA73910.1.
AY268434 Genomic DNA. Translation: AAP23201.1.
BC034761 mRNA. Translation: AAH34761.1.
CCDSCCDS8927.1.
PIRJC5784.
RefSeqNP_009195.1. NM_007264.3.
UniGeneHs.483909.

3D structure databases

ProteinModelPortalO15218.
SMRO15218. Positions 53-329.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000300098.

Chemistry

ChEMBLCHEMBL4356.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO15218.

Proteomic databases

PRIDEO15218.

Protocols and materials databases

DNASU11318.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300098; ENSP00000300098; ENSG00000166856.
GeneID11318.
KEGGhsa:11318.
UCSCuc001smk.3. human.

Organism-specific databases

CTD11318.
GeneCardsGC12P057388.
HGNCHGNC:13708. GPR182.
HPAHPA027037.
MIM605307. gene.
neXtProtNX_O15218.
PharmGKBPA162390165.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG147624.
HOGENOMHOG000220818.
HOVERGENHBG097691.
InParanoidO15218.
KOK04242.
OMAFANMYSS.
OrthoDBEOG70PBXP.
PhylomeDBO15218.
TreeFamTF333489.

Gene expression databases

BgeeO15218.
CleanExHS_GPR182.
GenevestigatorO15218.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001350. G10D_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00643. G10DORPHANR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR182.
GenomeRNAi11318.
NextBio42999.
PROO15218.
SOURCESearch...

Entry information

Entry nameGP182_HUMAN
AccessionPrimary (citable) accession number: O15218
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries