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Protein

G-protein coupled receptor 182

Gene

GPR182

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 182
Gene namesi
Name:GPR182
Synonyms:ADMR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:13708. GPR182.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757ExtracellularSequence AnalysisAdd
BLAST
Transmembranei58 – 7922Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini80 – 9011CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei91 – 11323Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini114 – 12714ExtracellularSequence AnalysisAdd
BLAST
Transmembranei128 – 14922Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini150 – 17021CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei171 – 19323Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini194 – 21724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei218 – 23922Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini240 – 25819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei259 – 28022Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini281 – 29919ExtracellularSequence AnalysisAdd
BLAST
Transmembranei300 – 32021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini321 – 40484CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162390165.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404G-protein coupled receptor 182PRO_0000069112Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi126 ↔ 202PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO15218.

PTM databases

PhosphoSiteiO15218.

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle, immune system, adrenal gland and liver.1 Publication

Gene expression databases

BgeeiO15218.
CleanExiHS_GPR182.
GenevestigatoriO15218.

Organism-specific databases

HPAiHPA027037.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000300098.

Structurei

3D structure databases

ProteinModelPortaliO15218.
SMRiO15218. Positions 53-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147624.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000220818.
HOVERGENiHBG097691.
InParanoidiO15218.
KOiK04242.
OMAiFANMYSS.
OrthoDBiEOG70PBXP.
PhylomeDBiO15218.
TreeFamiTF333489.

Family and domain databases

InterProiIPR001350. G10D_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00643. G10DORPHANR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKPSWGPG PSEGVTAVPT SDLGEIHNWT ELLDLFNHTL SECHVELSQS
60 70 80 90 100
TKRVVLFALY LAMFVVGLVE NLLVICVNWR GSGRAGLMNL YILNMAIADL
110 120 130 140 150
GIVLSLPVWM LEVTLDYTWL WGSFSCRFTH YFYFVNMYSS IFFLVCLSVD
160 170 180 190 200
RYVTLTSASP SWQRYQHRVR RAMCAGIWVL SAIIPLPEVV HIQLVEGPEP
210 220 230 240 250
MCLFMAPFET YSTWALAVAL STTILGFLLP FPLITVFNVL TACRLRQPGQ
260 270 280 290 300
PKSRRHCLLL CAYVAVFVMC WLPYHVTLLL LTLHGTHISL HCHLVHLLYF
310 320 330 340 350
FYDVIDCFSM LHCVINPILY NFLSPHFRGR LLNAVVHYLP KDQTKAGTCA
360 370 380 390 400
SSSSCSTQHS IIITKGDSQP AAAAPHPEPS LSFQAHHLLP NTSPISPTQP

LTPS
Length:404
Mass (Da):45,323
Last modified:January 1, 1998 - v1
Checksum:iEF187ECFDF2DC6C1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti349 – 3491C → R.
Corresponds to variant rs35493121 [ dbSNP | Ensembl ].
VAR_033464

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13583 mRNA. Translation: CAA73910.1.
AY268434 Genomic DNA. Translation: AAP23201.1.
BC034761 mRNA. Translation: AAH34761.1.
CCDSiCCDS8927.1.
PIRiJC5784.
RefSeqiNP_009195.1. NM_007264.3.
UniGeneiHs.483909.

Genome annotation databases

EnsembliENST00000300098; ENSP00000300098; ENSG00000166856.
GeneIDi11318.
KEGGihsa:11318.
UCSCiuc001smk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13583 mRNA. Translation: CAA73910.1.
AY268434 Genomic DNA. Translation: AAP23201.1.
BC034761 mRNA. Translation: AAH34761.1.
CCDSiCCDS8927.1.
PIRiJC5784.
RefSeqiNP_009195.1. NM_007264.3.
UniGeneiHs.483909.

3D structure databases

ProteinModelPortaliO15218.
SMRiO15218. Positions 53-329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000300098.

Chemistry

ChEMBLiCHEMBL4356.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO15218.

Proteomic databases

PRIDEiO15218.

Protocols and materials databases

DNASUi11318.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300098; ENSP00000300098; ENSG00000166856.
GeneIDi11318.
KEGGihsa:11318.
UCSCiuc001smk.3. human.

Organism-specific databases

CTDi11318.
GeneCardsiGC12P057388.
HGNCiHGNC:13708. GPR182.
HPAiHPA027037.
MIMi605307. gene.
neXtProtiNX_O15218.
PharmGKBiPA162390165.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG147624.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000220818.
HOVERGENiHBG097691.
InParanoidiO15218.
KOiK04242.
OMAiFANMYSS.
OrthoDBiEOG70PBXP.
PhylomeDBiO15218.
TreeFamiTF333489.

Miscellaneous databases

GeneWikiiGPR182.
GenomeRNAii11318.
NextBioi42999.
PROiO15218.
SOURCEiSearch...

Gene expression databases

BgeeiO15218.
CleanExiHS_GPR182.
GenevestigatoriO15218.

Family and domain databases

InterProiIPR001350. G10D_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00643. G10DORPHANR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system."
    Haenze J., Dittrich K., Dotsch J., Rascher W.
    Biochem. Biophys. Res. Commun. 240:183-188(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  4. "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response."
    Kennedy S.P., Sun D., Oleynek J.J., Hoth C.F., Kong J., Hill R.J.
    Biochem. Biophys. Res. Commun. 244:832-837(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOUBTS ON THE ORIGINAL FUNCTION.

Entry informationi

Entry nameiGP182_HUMAN
AccessioniPrimary (citable) accession number: O15218
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: January 7, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be a receptor for adrenomedullin.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.