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O15218

- GP182_HUMAN

UniProt

O15218 - GP182_HUMAN

Protein

G-protein coupled receptor 182

Gene

GPR182

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 182
    Gene namesi
    Name:GPR182
    Synonyms:ADMR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:13708. GPR182.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162390165.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404G-protein coupled receptor 182PRO_0000069112Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi126 ↔ 202PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO15218.

    PTM databases

    PhosphoSiteiO15218.

    Expressioni

    Tissue specificityi

    Highly expressed in heart, skeletal muscle, immune system, adrenal gland and liver.1 Publication

    Gene expression databases

    BgeeiO15218.
    CleanExiHS_GPR182.
    GenevestigatoriO15218.

    Organism-specific databases

    HPAiHPA027037.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000300098.

    Structurei

    3D structure databases

    ProteinModelPortaliO15218.
    SMRiO15218. Positions 53-329.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5757ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini80 – 9011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini114 – 12714ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini150 – 17021CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini194 – 21724ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini240 – 25819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini281 – 29919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini321 – 40484CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei58 – 7922Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei91 – 11323Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei128 – 14922Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei171 – 19323Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei218 – 23922Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei259 – 28022Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei300 – 32021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG147624.
    HOGENOMiHOG000220818.
    HOVERGENiHBG097691.
    InParanoidiO15218.
    KOiK04242.
    OMAiFANMYSS.
    OrthoDBiEOG70PBXP.
    PhylomeDBiO15218.
    TreeFamiTF333489.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001350. G10D_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00643. G10DORPHANR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O15218-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVKPSWGPG PSEGVTAVPT SDLGEIHNWT ELLDLFNHTL SECHVELSQS    50
    TKRVVLFALY LAMFVVGLVE NLLVICVNWR GSGRAGLMNL YILNMAIADL 100
    GIVLSLPVWM LEVTLDYTWL WGSFSCRFTH YFYFVNMYSS IFFLVCLSVD 150
    RYVTLTSASP SWQRYQHRVR RAMCAGIWVL SAIIPLPEVV HIQLVEGPEP 200
    MCLFMAPFET YSTWALAVAL STTILGFLLP FPLITVFNVL TACRLRQPGQ 250
    PKSRRHCLLL CAYVAVFVMC WLPYHVTLLL LTLHGTHISL HCHLVHLLYF 300
    FYDVIDCFSM LHCVINPILY NFLSPHFRGR LLNAVVHYLP KDQTKAGTCA 350
    SSSSCSTQHS IIITKGDSQP AAAAPHPEPS LSFQAHHLLP NTSPISPTQP 400
    LTPS 404
    Length:404
    Mass (Da):45,323
    Last modified:January 1, 1998 - v1
    Checksum:iEF187ECFDF2DC6C1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti349 – 3491C → R.
    Corresponds to variant rs35493121 [ dbSNP | Ensembl ].
    VAR_033464

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13583 mRNA. Translation: CAA73910.1.
    AY268434 Genomic DNA. Translation: AAP23201.1.
    BC034761 mRNA. Translation: AAH34761.1.
    CCDSiCCDS8927.1.
    PIRiJC5784.
    RefSeqiNP_009195.1. NM_007264.3.
    UniGeneiHs.483909.

    Genome annotation databases

    EnsembliENST00000300098; ENSP00000300098; ENSG00000166856.
    GeneIDi11318.
    KEGGihsa:11318.
    UCSCiuc001smk.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13583 mRNA. Translation: CAA73910.1 .
    AY268434 Genomic DNA. Translation: AAP23201.1 .
    BC034761 mRNA. Translation: AAH34761.1 .
    CCDSi CCDS8927.1.
    PIRi JC5784.
    RefSeqi NP_009195.1. NM_007264.3.
    UniGenei Hs.483909.

    3D structure databases

    ProteinModelPortali O15218.
    SMRi O15218. Positions 53-329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000300098.

    Chemistry

    ChEMBLi CHEMBL4356.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O15218.

    Proteomic databases

    PRIDEi O15218.

    Protocols and materials databases

    DNASUi 11318.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300098 ; ENSP00000300098 ; ENSG00000166856 .
    GeneIDi 11318.
    KEGGi hsa:11318.
    UCSCi uc001smk.3. human.

    Organism-specific databases

    CTDi 11318.
    GeneCardsi GC12P057388.
    HGNCi HGNC:13708. GPR182.
    HPAi HPA027037.
    MIMi 605307. gene.
    neXtProti NX_O15218.
    PharmGKBi PA162390165.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147624.
    HOGENOMi HOG000220818.
    HOVERGENi HBG097691.
    InParanoidi O15218.
    KOi K04242.
    OMAi FANMYSS.
    OrthoDBi EOG70PBXP.
    PhylomeDBi O15218.
    TreeFami TF333489.

    Miscellaneous databases

    GeneWikii GPR182.
    GenomeRNAii 11318.
    NextBioi 42999.
    PROi O15218.
    SOURCEi Search...

    Gene expression databases

    Bgeei O15218.
    CleanExi HS_GPR182.
    Genevestigatori O15218.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001350. G10D_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00643. G10DORPHANR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system."
      Haenze J., Dittrich K., Dotsch J., Rascher W.
      Biochem. Biophys. Res. Commun. 240:183-188(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    4. "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response."
      Kennedy S.P., Sun D., Oleynek J.J., Hoth C.F., Kong J., Hill R.J.
      Biochem. Biophys. Res. Commun. 244:832-837(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOUBTS ON THE ORIGINAL FUNCTION.

    Entry informationi

    Entry nameiGP182_HUMAN
    AccessioniPrimary (citable) accession number: O15218
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was originally thought to be a receptor for adrenomedullin.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3