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O15213

- WDR46_HUMAN

UniProt

O15213 - WDR46_HUMAN

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Protein

WD repeat-containing protein 46

Gene
WDR46, BING4, C6orf11, FP221
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiO15213.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 46
Alternative name(s):
WD repeat-containing protein BING4
Gene namesi
Name:WDR46
Synonyms:BING4, C6orf11
ORF Names:FP221
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:13923. WDR46.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25924.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610WD repeat-containing protein 46PRO_0000051395Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15213.
PaxDbiO15213.
PRIDEiO15213.

PTM databases

PhosphoSiteiO15213.

Expressioni

Gene expression databases

ArrayExpressiO15213.
BgeeiO15213.
CleanExiHS_WDR46.
GenevestigatoriO15213.

Organism-specific databases

HPAiHPA043004.

Interactioni

Protein-protein interaction databases

BioGridi114694. 4 interactions.
MINTiMINT-4994039.
STRINGi9606.ENSP00000363746.

Structurei

3D structure databases

ProteinModelPortaliO15213.
SMRiO15213. Positions 268-389.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati193 – 23442WD 1Add
BLAST
Repeati235 – 27238WD 2Add
BLAST
Repeati274 – 31239WD 3Add
BLAST
Repeati315 – 35440WD 4Add
BLAST
Repeati357 – 39640WD 5Add
BLAST
Repeati399 – 43638WD 6Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG301990.
HOVERGENiHBG050687.
InParanoidiO15213.
KOiK14768.
OMAiPRRYWEG.
PhylomeDBiO15213.
TreeFamiTF300861.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR012952. BING4_C_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08149. BING4CT. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM01033. BING4CT. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15213-1 [UniParc]FASTAAdd to Basket

« Hide

METAPKPGKD VPPKKDKLQT KRKKPRRYWE EETVPTTAGA SPGPPRNKKN    50
RELRPQRPKN AYILKKSRIS KKPQVPKKPR EWKNPESQRG LSGTQDPFPG 100
PAPVPVEVVQ KFCRIDKSRK LPHSKAKTRS RLEVAEAEEE ETSIKAARSE 150
LLLAEEPGFL EGEDGEDTAK ICQADIVEAV DIASAAKHFD LNLRQFGPYR 200
LNYSRTGRHL AFGGRRGHVA ALDWVTKKLM CEINVMEAVR DIRFLHSEAL 250
LAVAQNRWLH IYDNQGIELH CIRRCDRVTR LEFLPFHFLL ATASETGFLT 300
YLDVSVGKIV AALNARAGRL DVMSQNPYNA VIHLGHSNGT VSLWSPAMKE 350
PLAKILCHRG GVRAVAVDST GTYMATSGLD HQLKIFDLRG TYQPLSTRTL 400
PHGAGHLAFS QRGLLVAGMG DVVNIWAGQG KASPPSLEQP YLTHRLSGPV 450
HGLQFCPFED VLGVGHTGGI TSMLVPGAGE PNFDGLESNP YRSRKQRQEW 500
EVKALLEKVP AELICLDPRA LAEVDVISLE QGKKEQIERL GYDPQAKAPF 550
QPKPKQKGRS STASLVKRKR KVMDEEHRDK VRQSLQQQHH KEAKAKPTGA 600
RPSALDRFVR 610
Length:610
Mass (Da):68,071
Last modified:November 30, 2010 - v3
Checksum:i0C11DA8ED92CA39E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941T → A.3 Publications
Corresponds to variant rs3130257 [ dbSNP | Ensembl ].
VAR_053433
Natural varianti124 – 1241S → Y.
Corresponds to variant rs34704405 [ dbSNP | Ensembl ].
VAR_053434
Natural varianti341 – 3411V → A.1 Publication
Corresponds to variant rs14398 [ dbSNP | Ensembl ].
VAR_022025

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF447870 mRNA. Translation: AAQ04645.1.
AL662820 Genomic DNA. Translation: CAI18113.1.
AL662827 Genomic DNA. Translation: CAI17516.1.
AL844527, BX000343 Genomic DNA. Translation: CAI41833.1.
BX000343, AL844527 Genomic DNA. Translation: CAI41830.1.
Z97184, AL031228 Genomic DNA. Translation: CAB09994.2.
BC000388 mRNA. Translation: AAH00388.1.
CCDSiCCDS4772.1.
RefSeqiNP_001157739.1. NM_001164267.1.
NP_005443.3. NM_005452.5.
UniGeneiHs.520063.
Hs.671763.

Genome annotation databases

EnsembliENST00000374617; ENSP00000363746; ENSG00000227057.
ENST00000383208; ENSP00000372695; ENSG00000206284.
ENST00000432609; ENSP00000402869; ENSG00000236222.
ENST00000432933; ENSP00000399454; ENSG00000204221.
ENST00000457382; ENSP00000405614; ENSG00000226916.
GeneIDi9277.
KEGGihsa:9277.
UCSCiuc003ods.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF447870 mRNA. Translation: AAQ04645.1 .
AL662820 Genomic DNA. Translation: CAI18113.1 .
AL662827 Genomic DNA. Translation: CAI17516.1 .
AL844527 , BX000343 Genomic DNA. Translation: CAI41833.1 .
BX000343 , AL844527 Genomic DNA. Translation: CAI41830.1 .
Z97184 , AL031228 Genomic DNA. Translation: CAB09994.2 .
BC000388 mRNA. Translation: AAH00388.1 .
CCDSi CCDS4772.1.
RefSeqi NP_001157739.1. NM_001164267.1.
NP_005443.3. NM_005452.5.
UniGenei Hs.520063.
Hs.671763.

3D structure databases

ProteinModelPortali O15213.
SMRi O15213. Positions 268-389.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114694. 4 interactions.
MINTi MINT-4994039.
STRINGi 9606.ENSP00000363746.

PTM databases

PhosphoSitei O15213.

Proteomic databases

MaxQBi O15213.
PaxDbi O15213.
PRIDEi O15213.

Protocols and materials databases

DNASUi 9277.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374617 ; ENSP00000363746 ; ENSG00000227057 .
ENST00000383208 ; ENSP00000372695 ; ENSG00000206284 .
ENST00000432609 ; ENSP00000402869 ; ENSG00000236222 .
ENST00000432933 ; ENSP00000399454 ; ENSG00000204221 .
ENST00000457382 ; ENSP00000405614 ; ENSG00000226916 .
GeneIDi 9277.
KEGGi hsa:9277.
UCSCi uc003ods.3. human.

Organism-specific databases

CTDi 9277.
GeneCardsi GC06M033246.
GC06Mj33168.
GC06Mk33224.
GC06Mm33417.
GC06Mn33175.
H-InvDB HIX0058254.
HGNCi HGNC:13923. WDR46.
HPAi HPA043004.
MIMi 611440. gene.
neXtProti NX_O15213.
PharmGKBi PA25924.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG301990.
HOVERGENi HBG050687.
InParanoidi O15213.
KOi K14768.
OMAi PRRYWEG.
PhylomeDBi O15213.
TreeFami TF300861.

Enzyme and pathway databases

SignaLinki O15213.

Miscellaneous databases

GeneWikii WDR46.
GenomeRNAii 9277.
NextBioi 34769.
PROi O15213.
SOURCEi Search...

Gene expression databases

ArrayExpressi O15213.
Bgeei O15213.
CleanExi HS_WDR46.
Genevestigatori O15213.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR012952. BING4_C_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF08149. BING4CT. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM01033. BING4CT. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-94.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-341.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-94.
    Tissue: Lung.
  4. "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC."
    Herberg J.A., Beck S., Trowsdale J.
    J. Mol. Biol. 277:839-857(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-372, VARIANT ALA-94.
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiWDR46_HUMAN
AccessioniPrimary (citable) accession number: O15213
Secondary accession number(s): A6NDP5
, Q5HYZ0, Q5STK5, Q5STR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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