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O15213 (WDR46_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WD repeat-containing protein 46
Alternative name(s):
WD repeat-containing protein BING4
Gene names
Name:WDR46
Synonyms:BING4, C6orf11
ORF Names:FP221
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length610 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 6 WD repeats.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainRepeat
WD repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 610610WD repeat-containing protein 46
PRO_0000051395

Regions

Repeat193 – 23442WD 1
Repeat235 – 27238WD 2
Repeat274 – 31239WD 3
Repeat315 – 35440WD 4
Repeat357 – 39640WD 5
Repeat399 – 43638WD 6

Amino acid modifications

Modified residue411Phosphoserine Ref.5 Ref.6

Natural variations

Natural variant941T → A. Ref.1 Ref.3 Ref.4
Corresponds to variant rs3130257 [ dbSNP | Ensembl ].
VAR_053433
Natural variant1241S → Y.
Corresponds to variant rs34704405 [ dbSNP | Ensembl ].
VAR_053434
Natural variant3411V → A. Ref.2
Corresponds to variant rs14398 [ dbSNP | Ensembl ].
VAR_022025

Sequences

Sequence LengthMass (Da)Tools
O15213 [UniParc].

Last modified November 30, 2010. Version 3.
Checksum: 0C11DA8ED92CA39E

FASTA61068,071
        10         20         30         40         50         60 
METAPKPGKD VPPKKDKLQT KRKKPRRYWE EETVPTTAGA SPGPPRNKKN RELRPQRPKN 

        70         80         90        100        110        120 
AYILKKSRIS KKPQVPKKPR EWKNPESQRG LSGTQDPFPG PAPVPVEVVQ KFCRIDKSRK 

       130        140        150        160        170        180 
LPHSKAKTRS RLEVAEAEEE ETSIKAARSE LLLAEEPGFL EGEDGEDTAK ICQADIVEAV 

       190        200        210        220        230        240 
DIASAAKHFD LNLRQFGPYR LNYSRTGRHL AFGGRRGHVA ALDWVTKKLM CEINVMEAVR 

       250        260        270        280        290        300 
DIRFLHSEAL LAVAQNRWLH IYDNQGIELH CIRRCDRVTR LEFLPFHFLL ATASETGFLT 

       310        320        330        340        350        360 
YLDVSVGKIV AALNARAGRL DVMSQNPYNA VIHLGHSNGT VSLWSPAMKE PLAKILCHRG 

       370        380        390        400        410        420 
GVRAVAVDST GTYMATSGLD HQLKIFDLRG TYQPLSTRTL PHGAGHLAFS QRGLLVAGMG 

       430        440        450        460        470        480 
DVVNIWAGQG KASPPSLEQP YLTHRLSGPV HGLQFCPFED VLGVGHTGGI TSMLVPGAGE 

       490        500        510        520        530        540 
PNFDGLESNP YRSRKQRQEW EVKALLEKVP AELICLDPRA LAEVDVISLE QGKKEQIERL 

       550        560        570        580        590        600 
GYDPQAKAPF QPKPKQKGRS STASLVKRKR KVMDEEHRDK VRQSLQQQHH KEAKAKPTGA 

       610 
RPSALDRFVR 

« Hide

References

« Hide 'large scale' references
[1]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-94.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-341.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-94.
Tissue: Lung.
[4]"TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC."
Herberg J.A., Beck S., Trowsdale J.
J. Mol. Biol. 277:839-857(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-372, VARIANT ALA-94.
[5]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF447870 mRNA. Translation: AAQ04645.1.
AL662820 Genomic DNA. Translation: CAI18113.1.
AL662827 Genomic DNA. Translation: CAI17516.1.
AL844527, BX000343 Genomic DNA. Translation: CAI41833.1.
BX000343, AL844527 Genomic DNA. Translation: CAI41830.1.
Z97184, AL031228 Genomic DNA. Translation: CAB09994.2.
BC000388 mRNA. Translation: AAH00388.1.
CCDSCCDS4772.1.
RefSeqNP_001157739.1. NM_001164267.1.
NP_005443.3. NM_005452.5.
UniGeneHs.520063.
Hs.671763.

3D structure databases

ProteinModelPortalO15213.
SMRO15213. Positions 268-389.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114694. 4 interactions.
MINTMINT-4994039.
STRING9606.ENSP00000363746.

PTM databases

PhosphoSiteO15213.

Proteomic databases

MaxQBO15213.
PaxDbO15213.
PRIDEO15213.

Protocols and materials databases

DNASU9277.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374617; ENSP00000363746; ENSG00000227057.
ENST00000383208; ENSP00000372695; ENSG00000206284.
ENST00000432609; ENSP00000402869; ENSG00000236222.
ENST00000432933; ENSP00000399454; ENSG00000204221.
ENST00000457382; ENSP00000405614; ENSG00000226916.
GeneID9277.
KEGGhsa:9277.
UCSCuc003ods.3. human.

Organism-specific databases

CTD9277.
GeneCardsGC06M033246.
GC06Mj33168.
GC06Mk33224.
GC06Mm33417.
GC06Mn33175.
H-InvDBHIX0058254.
HGNCHGNC:13923. WDR46.
HPAHPA043004.
MIM611440. gene.
neXtProtNX_O15213.
PharmGKBPA25924.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG301990.
HOVERGENHBG050687.
InParanoidO15213.
KOK14768.
OMAPRRYWEG.
PhylomeDBO15213.
TreeFamTF300861.

Enzyme and pathway databases

SignaLinkO15213.

Gene expression databases

ArrayExpressO15213.
BgeeO15213.
CleanExHS_WDR46.
GenevestigatorO15213.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR012952. BING4_C_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF08149. BING4CT. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTSM01033. BING4CT. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiWDR46.
GenomeRNAi9277.
NextBio34769.
PROO15213.
SOURCESearch...

Entry information

Entry nameWDR46_HUMAN
AccessionPrimary (citable) accession number: O15213
Secondary accession number(s): A6NDP5 expand/collapse secondary AC list , Q5HYZ0, Q5STK5, Q5STR3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM