O15212PFD6_HUMANPrefoldin subunit 6Protein Ke2PFDN6HKE2PFD6Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoTAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC.NUCLEOTIDE SEQUENCE [GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.FUNCTIONLysine acetylation targets protein complexes and co-regulates major cellular functions.ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-21 AND LYS-66IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Initial characterization of the human central proteome.IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-66IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-66IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome.IDENTIFICATION IN THE PAQOSOME COMPLEXBinds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.Heterohexamer of two PFD-alpha type and four PFD-beta type subunits (By similarity). Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92 (PubMed:31738558).O15212Q13155false3O15212Q8TD31-3false3O15212P53567false3O15212Q9UK22false3O15212P22607false3O15212Q63ZY3false3O15212Q9BVG8-5false3O15212O15481false3O15212O95983-2false3O15212Q9NQG5false3Belongs to the prefoldin subunit beta family.3D-structureAcetylationChaperoneIsopeptide bondReference proteomeUbl conjugationMAELIQKKLQGEVEKYQQLQKDLSKSMSGRQKLEAQLTENNIVKEELALLDGSNVVFKLLGPVLVKQELGEARATVGKRLDYITAEIKRYESQLRDLERQSEQQRETLAQLQQEFQRAQAAKAGAPGKA
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