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O15212

- PFD6_HUMAN

UniProt

O15212 - PFD6_HUMAN

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Protein

Prefoldin subunit 6

Gene

PFDN6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.1 Publication

GO - Molecular functioni

  1. chaperone binding Source: UniProtKB
  2. unfolded protein binding Source: UniProtKB

GO - Biological processi

  1. 'de novo' posttranslational protein folding Source: Reactome
  2. cellular protein metabolic process Source: Reactome
  3. chaperone-mediated protein complex assembly Source: UniProtKB
  4. protein folding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiREACT_16936. Prefoldin mediated transfer of substrate to CCT/TriC.

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 6
Alternative name(s):
Protein Ke2
Gene namesi
Name:PFDN6
Synonyms:HKE2, PFD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:4926. PFDN6.

Subcellular locationi

GO - Cellular componenti

  1. prefoldin complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29304.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 129128Prefoldin subunit 6PRO_0000124850Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei21 – 211N6-acetyllysine1 Publication
Modified residuei66 – 661N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO15212.
PaxDbiO15212.
PeptideAtlasiO15212.
PRIDEiO15212.

PTM databases

PhosphoSiteiO15212.

Expressioni

Gene expression databases

BgeeiO15212.
CleanExiHS_PFDN6.
ExpressionAtlasiO15212. baseline.
GenevestigatoriO15212.

Organism-specific databases

HPAiHPA043032.
HPA048123.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

Protein-protein interaction databases

BioGridi115734. 25 interactions.
IntActiO15212. 12 interactions.
MINTiMINT-1142550.
STRINGi9606.ENSP00000363734.

Structurei

3D structure databases

ProteinModelPortaliO15212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiCOG1382.
HOGENOMiHOG000196242.
HOVERGENiHBG000199.
InParanoidiO15212.
KOiK04798.
OMAiYINGEIQ.
PhylomeDBiO15212.
TreeFamiTF315166.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15212-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAELIQKKLQ GEVEKYQQLQ KDLSKSMSGR QKLEAQLTEN NIVKEELALL
60 70 80 90 100
DGSNVVFKLL GPVLVKQELG EARATVGKRL DYITAEIKRY ESQLRDLERQ
110 120
SEQQRETLAQ LQQEFQRAQA AKAGAPGKA
Length:129
Mass (Da):14,583
Last modified:January 1, 1998 - v1
Checksum:i8F138EAAE512A312
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z97184 Genomic DNA. Translation: CAB09993.1.
BC039033 mRNA. Translation: AAH39033.1.
BC059783 mRNA. Translation: AAH59783.1.
CCDSiCCDS4773.1.
RefSeqiNP_001172110.1. NM_001185181.2.
NP_001252524.1. NM_001265595.1.
NP_001252525.1. NM_001265596.1.
NP_055075.1. NM_014260.3.
UniGeneiHs.446374.

Genome annotation databases

EnsembliENST00000374606; ENSP00000363734; ENSG00000204220.
ENST00000374607; ENSP00000363735; ENSG00000204220.
ENST00000374610; ENSP00000363738; ENSG00000204220.
ENST00000383207; ENSP00000372694; ENSG00000206283.
ENST00000395131; ENSP00000378563; ENSG00000204220.
ENST00000399383; ENSP00000382314; ENSG00000206283.
ENST00000399385; ENSP00000382316; ENSG00000206283.
ENST00000412289; ENSP00000402212; ENSG00000224782.
ENST00000425878; ENSP00000395462; ENSG00000224782.
ENST00000431830; ENSP00000402553; ENSG00000235692.
ENST00000432391; ENSP00000400152; ENSG00000235692.
ENST00000442285; ENSP00000404773; ENSG00000224782.
ENST00000445559; ENSP00000398171; ENSG00000237335.
ENST00000448594; ENSP00000403771; ENSG00000237335.
ENST00000451970; ENSP00000415678; ENSG00000235692.
ENST00000452658; ENSP00000412319; ENSG00000237335.
ENST00000547641; ENSP00000449925; ENSG00000235692.
ENST00000547952; ENSP00000448784; ENSG00000237335.
ENST00000548040; ENSP00000447540; ENSG00000206283.
ENST00000552711; ENSP00000448607; ENSG00000224782.
GeneIDi10471.
KEGGihsa:10471.
UCSCiuc003odt.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z97184 Genomic DNA. Translation: CAB09993.1 .
BC039033 mRNA. Translation: AAH39033.1 .
BC059783 mRNA. Translation: AAH59783.1 .
CCDSi CCDS4773.1.
RefSeqi NP_001172110.1. NM_001185181.2.
NP_001252524.1. NM_001265595.1.
NP_001252525.1. NM_001265596.1.
NP_055075.1. NM_014260.3.
UniGenei Hs.446374.

3D structure databases

ProteinModelPortali O15212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115734. 25 interactions.
IntActi O15212. 12 interactions.
MINTi MINT-1142550.
STRINGi 9606.ENSP00000363734.

PTM databases

PhosphoSitei O15212.

Proteomic databases

MaxQBi O15212.
PaxDbi O15212.
PeptideAtlasi O15212.
PRIDEi O15212.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374606 ; ENSP00000363734 ; ENSG00000204220 .
ENST00000374607 ; ENSP00000363735 ; ENSG00000204220 .
ENST00000374610 ; ENSP00000363738 ; ENSG00000204220 .
ENST00000383207 ; ENSP00000372694 ; ENSG00000206283 .
ENST00000395131 ; ENSP00000378563 ; ENSG00000204220 .
ENST00000399383 ; ENSP00000382314 ; ENSG00000206283 .
ENST00000399385 ; ENSP00000382316 ; ENSG00000206283 .
ENST00000412289 ; ENSP00000402212 ; ENSG00000224782 .
ENST00000425878 ; ENSP00000395462 ; ENSG00000224782 .
ENST00000431830 ; ENSP00000402553 ; ENSG00000235692 .
ENST00000432391 ; ENSP00000400152 ; ENSG00000235692 .
ENST00000442285 ; ENSP00000404773 ; ENSG00000224782 .
ENST00000445559 ; ENSP00000398171 ; ENSG00000237335 .
ENST00000448594 ; ENSP00000403771 ; ENSG00000237335 .
ENST00000451970 ; ENSP00000415678 ; ENSG00000235692 .
ENST00000452658 ; ENSP00000412319 ; ENSG00000237335 .
ENST00000547641 ; ENSP00000449925 ; ENSG00000235692 .
ENST00000547952 ; ENSP00000448784 ; ENSG00000237335 .
ENST00000548040 ; ENSP00000447540 ; ENSG00000206283 .
ENST00000552711 ; ENSP00000448607 ; ENSG00000224782 .
GeneIDi 10471.
KEGGi hsa:10471.
UCSCi uc003odt.2. human.

Organism-specific databases

CTDi 10471.
GeneCardsi GC06P033257.
GC06Pj33178.
GC06Pk33235.
GC06Pm33427.
GC06Pn33185.
HGNCi HGNC:4926. PFDN6.
HPAi HPA043032.
HPA048123.
MIMi 605660. gene.
neXtProti NX_O15212.
PharmGKBi PA29304.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1382.
HOGENOMi HOG000196242.
HOVERGENi HBG000199.
InParanoidi O15212.
KOi K04798.
OMAi YINGEIQ.
PhylomeDBi O15212.
TreeFami TF315166.

Enzyme and pathway databases

Reactomei REACT_16936. Prefoldin mediated transfer of substrate to CCT/TriC.

Miscellaneous databases

ChiTaRSi PFDN6. human.
GeneWikii Prefoldin_subunit_6.
GenomeRNAii 10471.
NextBioi 39710.
PROi O15212.
SOURCEi Search...

Gene expression databases

Bgeei O15212.
CleanExi HS_PFDN6.
ExpressionAtlasi O15212. baseline.
Genevestigatori O15212.

Family and domain databases

Gene3Di 1.10.287.370. 1 hit.
InterProi IPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view ]
Pfami PF01920. Prefoldin_2. 1 hit.
[Graphical view ]
SUPFAMi SSF46579. SSF46579. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC."
    Herberg J.A., Beck S., Trowsdale J.
    J. Mol. Biol. 277:839-857(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland and Pancreas.
  3. "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin."
    Vainberg I.E., Lewis S.A., Rommelaere H., Ampe C., Vandekerckhove J., Klein H.L., Cowan N.J.
    Cell 93:863-873(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-21 AND LYS-66, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPFD6_HUMAN
AccessioniPrimary (citable) accession number: O15212
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3