O15212 (PFD6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prefoldin subunit 6

Alternative name(s):
Protein Ke2

Gene names

Name:	PFDN6
Synonyms:	HKE2, PFD6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	129 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Ref.3
Subunit structure	Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
Sequence similarities	Belongs to the prefoldin subunit beta family.

Ontologies

Keywords
Molecular function	Chaperone
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	'de novo' posttranslational protein folding Traceable author statement. Source: Reactome chaperone-mediated protein complex assembly Inferred from direct assay Ref.3. Source: UniProtKB
Cellular_component	prefoldin complex Inferred from direct assay Ref.3. Source: UniProtKB
Molecular_function	chaperone binding Inferred from direct assay Ref.3. Source: UniProtKB unfolded protein binding Non-traceable author statement Ref.3. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 129	129	Prefoldin subunit 6		PRO_0000124850
Amino acid modifications
	Modified residue	21	1	N6-acetyllysine Ref.4
	Modified residue	66	1	N6-acetyllysine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	O15212 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 8F138EAAE512A312	FASTA	129	14,583
	10 20 30 40 50 60 MAELIQKKLQ GEVEKYQQLQ KDLSKSMSGR QKLEAQLTEN NIVKEELALL DGSNVVFKLL 70 80 90 100 110 120 GPVLVKQELG EARATVGKRL DYITAEIKRY ESQLRDLERQ SEQQRETLAQ LQQEFQRAQA AKAGAPGKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC." Herberg J.A., Beck S., Trowsdale J. J. Mol. Biol. 277:839-857(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland and Pancreas.
[3]	"Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin." Vainberg I.E., Lewis S.A., Rommelaere H., Ampe C., Vandekerckhove J., Klein H.L., Cowan N.J. Cell 93:863-873(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[4]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-21 AND LYS-66, MASS SPECTROMETRY.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z97184 Genomic DNA. Translation: CAB09993.1. BC039033 mRNA. Translation: AAH39033.1. BC059783 mRNA. Translation: AAH59783.1.
IPI	IPI00005657.
RefSeq	NP_001172110.1. NM_001185181.2. NP_001252524.1. NM_001265595.1. NP_001252525.1. NM_001265596.1. NP_055075.1. NM_014260.3.
UniGene	Hs.446374.
3D structure databases
ProteinModelPortal	O15212.
SMR	O15212. Positions 1-113.
ModBase	Search...
Protein-protein interaction databases
IntAct	O15212. 7 interactions.
MINT	MINT-1142550.
STRING	9606.ENSP00000363734.
PTM databases
PhosphoSite	O15212.
Proteomic databases
PaxDb	O15212.
PeptideAtlas	O15212.
PRIDE	O15212.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374606; ENSP00000363734; ENSG00000204220. ENST00000374607; ENSP00000363735; ENSG00000204220. ENST00000374610; ENSP00000363738; ENSG00000204220. ENST00000383207; ENSP00000372694; ENSG00000206283. ENST00000395131; ENSP00000378563; ENSG00000204220. ENST00000399383; ENSP00000382314; ENSG00000206283. ENST00000399385; ENSP00000382316; ENSG00000206283. ENST00000412289; ENSP00000402212; ENSG00000224782. ENST00000425878; ENSP00000395462; ENSG00000224782. ENST00000431830; ENSP00000402553; ENSG00000235692. ENST00000432391; ENSP00000400152; ENSG00000235692. ENST00000442285; ENSP00000404773; ENSG00000224782. ENST00000445559; ENSP00000398171; ENSG00000237335. ENST00000448594; ENSP00000403771; ENSG00000237335. ENST00000451970; ENSP00000415678; ENSG00000235692. ENST00000452658; ENSP00000412319; ENSG00000237335. ENST00000547641; ENSP00000449925; ENSG00000235692. ENST00000547952; ENSP00000448784; ENSG00000237335. ENST00000548040; ENSP00000447540; ENSG00000206283. ENST00000552711; ENSP00000448607; ENSG00000224782.
GeneID	10471.
KEGG	hsa:10471.
UCSC	uc003odt.1. human.
Organism-specific databases
CTD	10471.
GeneCards	GC06P033257.
HGNC	HGNC:4926. PFDN6.
HPA	HPA043032. HPA048123.
MIM	605660. gene.
neXtProt	NX_O15212.
PharmGKB	PA29304.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1382.
HOGENOM	HOG000196242.
HOVERGEN	HBG000199.
InParanoid	O15212.
KO	K04798.
OMA	GKRIEYI.
OrthoDB	EOG4SBF0B.
PhylomeDB	O15212.
Enzyme and pathway databases
Reactome	REACT_17015. Metabolism of proteins.
Gene expression databases
ArrayExpress	O15212.
Bgee	O15212.
CleanEx	HS_PFDN6.
Genevestigator	O15212.
GermOnline	ENSG00000204220. Homo sapiens.
Family and domain databases
InterPro	IPR002777. PFD_beta-like. IPR009053. Prefoldin. [Graphical view]
Pfam	PF01920. Prefoldin_2. 1 hit. [Graphical view]
SUPFAM	SSF46579. Prefoldin. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	PFDN6. human.
GenomeRNAi	10471.
NextBio	39710.
SOURCE	Search...

Entry information

Entry name

PFD6_HUMAN

Accession

Primary (citable) accession number: O15212

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.