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O15212

- PFD6_HUMAN

UniProt

O15212 - PFD6_HUMAN

Protein

Prefoldin subunit 6

Gene

PFDN6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.1 Publication

    GO - Molecular functioni

    1. chaperone binding Source: UniProtKB
    2. unfolded protein binding Source: UniProtKB

    GO - Biological processi

    1. 'de novo' posttranslational protein folding Source: Reactome
    2. cellular protein metabolic process Source: Reactome
    3. chaperone-mediated protein complex assembly Source: UniProtKB
    4. protein folding Source: UniProtKB

    Keywords - Molecular functioni

    Chaperone

    Enzyme and pathway databases

    ReactomeiREACT_16936. Prefoldin mediated transfer of substrate to CCT/TriC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prefoldin subunit 6
    Alternative name(s):
    Protein Ke2
    Gene namesi
    Name:PFDN6
    Synonyms:HKE2, PFD6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4926. PFDN6.

    Subcellular locationi

    GO - Cellular componenti

    1. prefoldin complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29304.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 129128Prefoldin subunit 6PRO_0000124850Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei21 – 211N6-acetyllysine1 Publication
    Modified residuei66 – 661N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO15212.
    PaxDbiO15212.
    PeptideAtlasiO15212.
    PRIDEiO15212.

    PTM databases

    PhosphoSiteiO15212.

    Expressioni

    Gene expression databases

    ArrayExpressiO15212.
    BgeeiO15212.
    CleanExiHS_PFDN6.
    GenevestigatoriO15212.

    Organism-specific databases

    HPAiHPA043032.
    HPA048123.

    Interactioni

    Subunit structurei

    Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

    Protein-protein interaction databases

    BioGridi115734. 24 interactions.
    IntActiO15212. 12 interactions.
    MINTiMINT-1142550.
    STRINGi9606.ENSP00000363734.

    Structurei

    3D structure databases

    ProteinModelPortaliO15212.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the prefoldin subunit beta family.Curated

    Phylogenomic databases

    eggNOGiCOG1382.
    HOGENOMiHOG000196242.
    HOVERGENiHBG000199.
    InParanoidiO15212.
    KOiK04798.
    OMAiYINGEIQ.
    PhylomeDBiO15212.
    TreeFamiTF315166.

    Family and domain databases

    Gene3Di1.10.287.370. 1 hit.
    InterProiIPR002777. PFD_beta-like.
    IPR009053. Prefoldin.
    [Graphical view]
    PfamiPF01920. Prefoldin_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF46579. SSF46579. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O15212-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAELIQKKLQ GEVEKYQQLQ KDLSKSMSGR QKLEAQLTEN NIVKEELALL    50
    DGSNVVFKLL GPVLVKQELG EARATVGKRL DYITAEIKRY ESQLRDLERQ 100
    SEQQRETLAQ LQQEFQRAQA AKAGAPGKA 129
    Length:129
    Mass (Da):14,583
    Last modified:January 1, 1998 - v1
    Checksum:i8F138EAAE512A312
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z97184 Genomic DNA. Translation: CAB09993.1.
    BC039033 mRNA. Translation: AAH39033.1.
    BC059783 mRNA. Translation: AAH59783.1.
    CCDSiCCDS4773.1.
    RefSeqiNP_001172110.1. NM_001185181.2.
    NP_001252524.1. NM_001265595.1.
    NP_001252525.1. NM_001265596.1.
    NP_055075.1. NM_014260.3.
    UniGeneiHs.446374.

    Genome annotation databases

    EnsembliENST00000374606; ENSP00000363734; ENSG00000204220.
    ENST00000374607; ENSP00000363735; ENSG00000204220.
    ENST00000374610; ENSP00000363738; ENSG00000204220.
    ENST00000383207; ENSP00000372694; ENSG00000206283.
    ENST00000395131; ENSP00000378563; ENSG00000204220.
    ENST00000399383; ENSP00000382314; ENSG00000206283.
    ENST00000399385; ENSP00000382316; ENSG00000206283.
    ENST00000412289; ENSP00000402212; ENSG00000224782.
    ENST00000425878; ENSP00000395462; ENSG00000224782.
    ENST00000431830; ENSP00000402553; ENSG00000235692.
    ENST00000432391; ENSP00000400152; ENSG00000235692.
    ENST00000442285; ENSP00000404773; ENSG00000224782.
    ENST00000445559; ENSP00000398171; ENSG00000237335.
    ENST00000448594; ENSP00000403771; ENSG00000237335.
    ENST00000451970; ENSP00000415678; ENSG00000235692.
    ENST00000452658; ENSP00000412319; ENSG00000237335.
    ENST00000547641; ENSP00000449925; ENSG00000235692.
    ENST00000547952; ENSP00000448784; ENSG00000237335.
    ENST00000548040; ENSP00000447540; ENSG00000206283.
    ENST00000552711; ENSP00000448607; ENSG00000224782.
    GeneIDi10471.
    KEGGihsa:10471.
    UCSCiuc003odt.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z97184 Genomic DNA. Translation: CAB09993.1 .
    BC039033 mRNA. Translation: AAH39033.1 .
    BC059783 mRNA. Translation: AAH59783.1 .
    CCDSi CCDS4773.1.
    RefSeqi NP_001172110.1. NM_001185181.2.
    NP_001252524.1. NM_001265595.1.
    NP_001252525.1. NM_001265596.1.
    NP_055075.1. NM_014260.3.
    UniGenei Hs.446374.

    3D structure databases

    ProteinModelPortali O15212.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115734. 24 interactions.
    IntActi O15212. 12 interactions.
    MINTi MINT-1142550.
    STRINGi 9606.ENSP00000363734.

    PTM databases

    PhosphoSitei O15212.

    Proteomic databases

    MaxQBi O15212.
    PaxDbi O15212.
    PeptideAtlasi O15212.
    PRIDEi O15212.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374606 ; ENSP00000363734 ; ENSG00000204220 .
    ENST00000374607 ; ENSP00000363735 ; ENSG00000204220 .
    ENST00000374610 ; ENSP00000363738 ; ENSG00000204220 .
    ENST00000383207 ; ENSP00000372694 ; ENSG00000206283 .
    ENST00000395131 ; ENSP00000378563 ; ENSG00000204220 .
    ENST00000399383 ; ENSP00000382314 ; ENSG00000206283 .
    ENST00000399385 ; ENSP00000382316 ; ENSG00000206283 .
    ENST00000412289 ; ENSP00000402212 ; ENSG00000224782 .
    ENST00000425878 ; ENSP00000395462 ; ENSG00000224782 .
    ENST00000431830 ; ENSP00000402553 ; ENSG00000235692 .
    ENST00000432391 ; ENSP00000400152 ; ENSG00000235692 .
    ENST00000442285 ; ENSP00000404773 ; ENSG00000224782 .
    ENST00000445559 ; ENSP00000398171 ; ENSG00000237335 .
    ENST00000448594 ; ENSP00000403771 ; ENSG00000237335 .
    ENST00000451970 ; ENSP00000415678 ; ENSG00000235692 .
    ENST00000452658 ; ENSP00000412319 ; ENSG00000237335 .
    ENST00000547641 ; ENSP00000449925 ; ENSG00000235692 .
    ENST00000547952 ; ENSP00000448784 ; ENSG00000237335 .
    ENST00000548040 ; ENSP00000447540 ; ENSG00000206283 .
    ENST00000552711 ; ENSP00000448607 ; ENSG00000224782 .
    GeneIDi 10471.
    KEGGi hsa:10471.
    UCSCi uc003odt.2. human.

    Organism-specific databases

    CTDi 10471.
    GeneCardsi GC06P033257.
    GC06Pj33178.
    GC06Pk33235.
    GC06Pm33427.
    GC06Pn33185.
    HGNCi HGNC:4926. PFDN6.
    HPAi HPA043032.
    HPA048123.
    MIMi 605660. gene.
    neXtProti NX_O15212.
    PharmGKBi PA29304.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1382.
    HOGENOMi HOG000196242.
    HOVERGENi HBG000199.
    InParanoidi O15212.
    KOi K04798.
    OMAi YINGEIQ.
    PhylomeDBi O15212.
    TreeFami TF315166.

    Enzyme and pathway databases

    Reactomei REACT_16936. Prefoldin mediated transfer of substrate to CCT/TriC.

    Miscellaneous databases

    ChiTaRSi PFDN6. human.
    GeneWikii Prefoldin_subunit_6.
    GenomeRNAii 10471.
    NextBioi 39710.
    PROi O15212.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15212.
    Bgeei O15212.
    CleanExi HS_PFDN6.
    Genevestigatori O15212.

    Family and domain databases

    Gene3Di 1.10.287.370. 1 hit.
    InterProi IPR002777. PFD_beta-like.
    IPR009053. Prefoldin.
    [Graphical view ]
    Pfami PF01920. Prefoldin_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46579. SSF46579. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC."
      Herberg J.A., Beck S., Trowsdale J.
      J. Mol. Biol. 277:839-857(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland and Pancreas.
    3. "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin."
      Vainberg I.E., Lewis S.A., Rommelaere H., Ampe C., Vandekerckhove J., Klein H.L., Cowan N.J.
      Cell 93:863-873(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-21 AND LYS-66, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPFD6_HUMAN
    AccessioniPrimary (citable) accession number: O15212
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3