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Protein

Prefoldin subunit 6

Gene

PFDN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.1 Publication

GO - Molecular functioni

  • chaperone binding Source: UniProtKB
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

  • chaperone-mediated protein complex assembly Source: UniProtKB
  • protein folding Source: GO_Central

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 6
Alternative name(s):
Protein Ke2
Gene namesi
Name:PFDN6
Synonyms:HKE2, PFD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204220.9
HGNCiHGNC:4926 PFDN6
MIMi605660 gene
neXtProtiNX_O15212

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi10471
OpenTargetsiENSG00000204220
PharmGKBiPA29304

Polymorphism and mutation databases

BioMutaiPFDN6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001248502 – 129Prefoldin subunit 6Add BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei21N6-acetyllysineCombined sources1
Modified residuei66N6-acetyllysine; alternateCombined sources1
Cross-linki66Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki66Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiO15212
PaxDbiO15212
PeptideAtlasiO15212
PRIDEiO15212
ProteomicsDBi48512
TopDownProteomicsiO15212

PTM databases

iPTMnetiO15212
PhosphoSitePlusiO15212

Expressioni

Gene expression databases

BgeeiENSG00000204220
CleanExiHS_PFDN6
ExpressionAtlasiO15212 baseline and differential
GenevisibleiO15212 HS

Organism-specific databases

HPAiHPA043032
HPA048123

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

GO - Molecular functioni

  • chaperone binding Source: UniProtKB
  • unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115734, 54 interactors
CORUMiO15212
DIPiDIP-50304N
IntActiO15212, 31 interactors
STRINGi9606.ENSP00000363734

Structurei

3D structure databases

ProteinModelPortaliO15212
SMRiO15212
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiKOG3478 Eukaryota
COG1382 LUCA
GeneTreeiENSGT00390000010512
HOGENOMiHOG000196242
HOVERGENiHBG000199
InParanoidiO15212
KOiK04798
OMAiIYKLTGP
OrthoDBiEOG091G105E
PhylomeDBiO15212
TreeFamiTF315166

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR002777 PFD_beta-like
IPR009053 Prefoldin
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O15212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELIQKKLQ GEVEKYQQLQ KDLSKSMSGR QKLEAQLTEN NIVKEELALL
60 70 80 90 100
DGSNVVFKLL GPVLVKQELG EARATVGKRL DYITAEIKRY ESQLRDLERQ
110 120
SEQQRETLAQ LQQEFQRAQA AKAGAPGKA
Length:129
Mass (Da):14,583
Last modified:January 1, 1998 - v1
Checksum:i8F138EAAE512A312
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97184 Genomic DNA Translation: CAB09993.1
BC039033 mRNA Translation: AAH39033.1
BC059783 mRNA Translation: AAH59783.1
CCDSiCCDS4773.1
RefSeqiNP_001172110.1, NM_001185181.2
NP_001252524.1, NM_001265595.1
NP_001252525.1, NM_001265596.1
NP_055075.1, NM_014260.3
UniGeneiHs.446374

Genome annotation databases

EnsembliENST00000374606; ENSP00000363734; ENSG00000204220
ENST00000374607; ENSP00000363735; ENSG00000204220
ENST00000374610; ENSP00000363738; ENSG00000204220
ENST00000383207; ENSP00000372694; ENSG00000206283
ENST00000395131; ENSP00000378563; ENSG00000204220
ENST00000399383; ENSP00000382314; ENSG00000206283
ENST00000399385; ENSP00000382316; ENSG00000206283
ENST00000412289; ENSP00000402212; ENSG00000224782
ENST00000425878; ENSP00000395462; ENSG00000224782
ENST00000431830; ENSP00000402553; ENSG00000235692
ENST00000432391; ENSP00000400152; ENSG00000235692
ENST00000442285; ENSP00000404773; ENSG00000224782
ENST00000445559; ENSP00000398171; ENSG00000237335
ENST00000448594; ENSP00000403771; ENSG00000237335
ENST00000451970; ENSP00000415678; ENSG00000235692
ENST00000452658; ENSP00000412319; ENSG00000237335
ENST00000547641; ENSP00000449925; ENSG00000235692
ENST00000547952; ENSP00000448784; ENSG00000237335
ENST00000548040; ENSP00000447540; ENSG00000206283
ENST00000552711; ENSP00000448607; ENSG00000224782
GeneIDi10471
KEGGihsa:10471

Similar proteinsi

Entry informationi

Entry nameiPFD6_HUMAN
AccessioniPrimary (citable) accession number: O15212
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: June 20, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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