Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger and BTB domain-containing protein 22

Gene

ZBTB22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri486 – 507C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri513 – 535C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 562C2H2-type 3PROSITE-ProRule annotationAdd BLAST22

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168351-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 22
Alternative name(s):
Protein BING1
Zinc finger and BTB domain-containing protein 22A
Zinc finger protein 297
Gene namesi
Name:ZBTB22
Synonyms:BING1, ZBTB22A, ZNF297
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13085. ZBTB22.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9278.
OpenTargetsiENSG00000236104.
ENSG00000237056.
PharmGKBiPA37661.

Polymorphism and mutation databases

BioMutaiZBTB22.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475171 – 634Zinc finger and BTB domain-containing protein 22Add BLAST634

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei202PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO15209.
PaxDbiO15209.
PeptideAtlasiO15209.
PRIDEiO15209.

PTM databases

iPTMnetiO15209.
PhosphoSitePlusiO15209.

Expressioni

Gene expression databases

BgeeiENSG00000206280.
CleanExiHS_ZBTB22.
ExpressionAtlasiO15209. baseline and differential.
GenevisibleiO15209. HS.

Organism-specific databases

HPAiHPA043848.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
A8KA833EBI-723574,EBI-10174961
FXR2P511163EBI-723574,EBI-740459
MCRS1Q96EZ85EBI-723574,EBI-348259
MLLT6Q6P2C63EBI-723574,EBI-5773143
PIN1Q135263EBI-723574,EBI-714158
RBM39Q14498-33EBI-723574,EBI-6654703

Protein-protein interaction databases

BioGridi114695. 10 interactors.
DIPiDIP-62047N.
IntActiO15209. 15 interactors.
MINTiMINT-1402804.
STRINGi9606.ENSP00000404403.

Structurei

3D structure databases

ProteinModelPortaliO15209.
SMRiO15209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 121BTBPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri486 – 507C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri513 – 535C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 562C2H2-type 3PROSITE-ProRule annotationAdd BLAST22

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231975.
HOVERGENiHBG056510.
InParanoidiO15209.
KOiK10502.
OMAiEDFPSAY.
OrthoDBiEOG091G06Z9.
PhylomeDBiO15209.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR029833. ZBT22/43.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24414:SF4. PTHR24414:SF4. 3 hits.
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPSPLSPSG AALPLPLSLA PPPLPLPAAA VVHVSFPEVT SALLESLNQQ
60 70 80 90 100
RLQGQLCDVS IRVQGREFRA HRAVLAASSP YFHDQVLLKG MTSISLPSVM
110 120 130 140 150
DPGAFETVLA SAYTGRLSMA AADIVNFLTV GSVLQMWHIV DKCTELLREG
160 170 180 190 200
RASATTTITT AAATSVTVPG AGVPSGSGGT VAPATMGSAR SHASSRASEN
210 220 230 240 250
QSPSSSNYFS PRESTDFSSS SQEAFAASAV GSGERRGGGP VFPAPVVGSG
260 270 280 290 300
GATSGKLLLE ADELCDDGGD GRGAVVPGAG LRRPTYTPPS IMPQKHWVYV
310 320 330 340 350
KRGGNCPAPT PLVPQDPDLE EEEEEEDLVL TCEDDEDEEL GGSSRVPVGG
360 370 380 390 400
GPEATLSISD VRTLSEPPDK GEEQVNFCES SNDFGPYEGG GPVAGLDDSG
410 420 430 440 450
GPTPSSYAPS HPPRPLLPLD MQGNQILVFP SSSSSSSSQA PGQPPGNQAE
460 470 480 490 500
HGAVTVGGTS VGSLGVPGSV GGVPGGTGSG DGNKIFLCHC GKAFSHKSMR
510 520 530 540 550
DRHVNMHLNL RPFDCPVCNK KFKMKHHLTE HMKTHTGLKP YECGVCAKKF
560 570 580 590 600
MWRDSFMRHR GHCERRHRLG GVGAVPGPGT PTGPSLPSKR ESPGVGGGSG
610 620 630
DEASAATPPS SRRVWSPPRV HKVEMGFGGG GGAN
Length:634
Mass (Da):65,602
Last modified:January 1, 1998 - v1
Checksum:i9CC1867213D6DEF7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057457250G → A.Corresponds to variant rs35663442dbSNPEnsembl.1
Natural variantiVAR_022702310T → A.3 PublicationsCorresponds to variant rs3130100dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97183 Genomic DNA. No translation available.
Z97184 Genomic DNA. Translation: CAB09990.1.
AK315747 mRNA. Translation: BAG38101.1.
AL662820 Genomic DNA. Translation: CAI18123.1.
AL662827 Genomic DNA. Translation: CAI17526.1.
BX248088 Genomic DNA. Translation: CAI41787.2.
CR759786 Genomic DNA. Translation: CAQ08263.1.
CR759817 Genomic DNA. Translation: CAQ08033.1.
CH471081 Genomic DNA. Translation: EAX03721.1.
BC018541 mRNA. Translation: AAH18541.1.
CCDSiCCDS4775.1.
RefSeqiNP_001138810.1. NM_001145338.1.
NP_005444.4. NM_005453.4.
UniGeneiHs.206770.

Genome annotation databases

EnsembliENST00000383196; ENSP00000372683; ENSG00000206280.
ENST00000416097; ENSP00000393514; ENSG00000229253.
ENST00000418540; ENSP00000388191; ENSG00000227780.
ENST00000418724; ENSP00000404403; ENSG00000236104.
ENST00000431845; ENSP00000407545; ENSG00000236104.
ENST00000445320; ENSP00000396292; ENSG00000237056.
GeneIDi9278.
KEGGihsa:9278.
UCSCiuc003oeb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97183 Genomic DNA. No translation available.
Z97184 Genomic DNA. Translation: CAB09990.1.
AK315747 mRNA. Translation: BAG38101.1.
AL662820 Genomic DNA. Translation: CAI18123.1.
AL662827 Genomic DNA. Translation: CAI17526.1.
BX248088 Genomic DNA. Translation: CAI41787.2.
CR759786 Genomic DNA. Translation: CAQ08263.1.
CR759817 Genomic DNA. Translation: CAQ08033.1.
CH471081 Genomic DNA. Translation: EAX03721.1.
BC018541 mRNA. Translation: AAH18541.1.
CCDSiCCDS4775.1.
RefSeqiNP_001138810.1. NM_001145338.1.
NP_005444.4. NM_005453.4.
UniGeneiHs.206770.

3D structure databases

ProteinModelPortaliO15209.
SMRiO15209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114695. 10 interactors.
DIPiDIP-62047N.
IntActiO15209. 15 interactors.
MINTiMINT-1402804.
STRINGi9606.ENSP00000404403.

PTM databases

iPTMnetiO15209.
PhosphoSitePlusiO15209.

Polymorphism and mutation databases

BioMutaiZBTB22.

Proteomic databases

MaxQBiO15209.
PaxDbiO15209.
PeptideAtlasiO15209.
PRIDEiO15209.

Protocols and materials databases

DNASUi9278.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383196; ENSP00000372683; ENSG00000206280.
ENST00000416097; ENSP00000393514; ENSG00000229253.
ENST00000418540; ENSP00000388191; ENSG00000227780.
ENST00000418724; ENSP00000404403; ENSG00000236104.
ENST00000431845; ENSP00000407545; ENSG00000236104.
ENST00000445320; ENSP00000396292; ENSG00000237056.
GeneIDi9278.
KEGGihsa:9278.
UCSCiuc003oeb.4. human.

Organism-specific databases

CTDi9278.
DisGeNETi9278.
GeneCardsiZBTB22.
HGNCiHGNC:13085. ZBTB22.
HPAiHPA043848.
MIMi611439. gene.
neXtProtiNX_O15209.
OpenTargetsiENSG00000236104.
ENSG00000237056.
PharmGKBiPA37661.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231975.
HOVERGENiHBG056510.
InParanoidiO15209.
KOiK10502.
OMAiEDFPSAY.
OrthoDBiEOG091G06Z9.
PhylomeDBiO15209.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168351-MONOMER.

Miscellaneous databases

ChiTaRSiZBTB22. human.
GenomeRNAii9278.
PROiO15209.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000206280.
CleanExiHS_ZBTB22.
ExpressionAtlasiO15209. baseline and differential.
GenevisibleiO15209. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR029833. ZBT22/43.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24414:SF4. PTHR24414:SF4. 3 hits.
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT22_HUMAN
AccessioniPrimary (citable) accession number: O15209
Secondary accession number(s): B0V007
, Q5HYV4, Q5STL0, Q5STR7, Q8WV82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.