Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O15204

- ADEC1_HUMAN

UniProt

O15204 - ADEC1_HUMAN

Protein

ADAM DEC1

Gene

ADAMDEC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May play an important role in the control of the immune response and during pregnancy.By similarity

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi352 – 3521Zinc; catalyticBy similarity
    Active sitei353 – 3531PROSITE-ProRule annotation
    Metal bindingi356 – 3561Zinc; catalyticBy similarity
    Metal bindingi362 – 3621Zinc; catalyticSequence Analysis

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: UniProtKB
    2. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. immune response Source: UniProtKB
    2. negative regulation of cell adhesion Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM12.219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADAM DEC1 (EC:3.4.24.-)
    Alternative name(s):
    A disintegrin and metalloproteinase domain-like protein decysin-1
    Short name:
    ADAM-like protein decysin-1
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:16299. ADAMDEC1.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24535.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Propeptidei31 – 205175Sequence AnalysisPRO_0000029146Add
    BLAST
    Chaini206 – 470265ADAM DEC1PRO_0000029147Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...) (complex)1 Publication
    Glycosylationi237 – 2371N-linked (GlcNAc...)1 Publication
    Disulfide bondi328 ↔ 407By similarity
    Disulfide bondi369 ↔ 374By similarity
    Glycosylationi466 – 4661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiO15204.
    PeptideAtlasiO15204.
    PRIDEiO15204.

    PTM databases

    PhosphoSiteiO15204.

    Expressioni

    Tissue specificityi

    Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC.2 Publications

    Inductioni

    Induced during DC maturation and up-regulated in response to T-cell signals. In macrophage up-regulated by bacterial lipopolysaccharides (LPS). Up-regulated by 1-alpha,25-dihydroxyvitamin D3 during differentiation of primary monocyte into macrophage.2 Publications

    Gene expression databases

    ArrayExpressiO15204.
    BgeeiO15204.
    CleanExiHS_ADAMDEC1.
    GenevestigatoriO15204.

    Organism-specific databases

    HPAiHPA028317.

    Interactioni

    Protein-protein interaction databases

    IntActiO15204. 1 interaction.
    STRINGi9606.ENSP00000256412.

    Structurei

    3D structure databases

    ProteinModelPortaliO15204.
    SMRiO15204. Positions 218-461.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini218 – 412195Peptidase M12BPROSITE-ProRule annotationAdd
    BLAST
    Domaini420 – 47051DisintegrinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 disintegrin domain.PROSITE-ProRule annotation
    Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG280097.
    HOGENOMiHOG000230883.
    HOVERGENiHBG106501.
    InParanoidiO15204.
    KOiK08634.
    OMAiLRGYFTH.
    OrthoDBiEOG7CNZFH.
    PhylomeDBiO15204.
    TreeFamiTF314733.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    InterProiIPR001762. Blood-coag_inhib_Disintegrin.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view]
    PfamiPF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view]
    SMARTiSM00050. DISIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF57552. SSF57552. 1 hit.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O15204-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLRGISQLPA VATMSWVLLP VLWLIVQTQA IAIKQTPELT LHEIVCPKKL    50
    HILHKREIKN NQTEKHGKEE RYEPEVQYQM ILNGEEIILS LQKTKHLLGP 100
    DYTETLYSPR GEEITTKPEN MEHCYYKGNI LNEKNSVASI STCDGLRGYF 150
    THHHQRYQIK PLKSTDEKEH AVFTSNQEEQ DPANHTCGVK STDGKQGPIR 200
    ISRSLKSPEK EDFLRAQKYI DLYLVLDNAF YKNYNENLTL IRSFVFDVMN 250
    LLNVIYNTID VQVALVGMEI WSDGDKIKVV PSASTTFDNF LRWHSSNLGK 300
    KIHDHAQLLS GISFNNRRVG LAASNSLCSP SSVAVIEAKK KNNVALVGVM 350
    SHELGHVLGM PDVPFNTKCP SGSCVMNQYL SSKFPKDFST SCRAHFERYL 400
    LSQKPKCLLQ APIPTNIMTT PVCGNHLLEV GEDCDCGSPK ECTNLCCEAL 450
    TCKLKPGTDC GGDAPNHTTE 470
    Length:470
    Mass (Da):52,775
    Last modified:November 1, 1999 - v2
    Checksum:i35A454DD8A6A7E53
    GO
    Isoform 2 (identifier: O15204-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:391
    Mass (Da):43,557
    Checksum:i68CF640D7B6A71D8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti121 – 1211M → T.
    Corresponds to variant rs7007084 [ dbSNP | Ensembl ].
    VAR_024598
    Natural varianti444 – 4441N → S.
    Corresponds to variant rs3765124 [ dbSNP | Ensembl ].
    VAR_021848

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7979Missing in isoform 2. 1 PublicationVSP_043124Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13323 mRNA. Translation: CAA73764.2.
    AK316320 mRNA. Translation: BAH14691.1.
    AK316322 mRNA. Translation: BAH14693.1.
    AC120193 Genomic DNA. No translation available.
    BC069582 mRNA. Translation: AAH69582.1.
    BC074877 mRNA. Translation: AAH74877.1.
    BC074878 mRNA. Translation: AAH74878.1.
    CCDSiCCDS55212.1. [O15204-2]
    CCDS6044.1. [O15204-1]
    RefSeqiNP_001138743.1. NM_001145271.1. [O15204-2]
    NP_001138744.1. NM_001145272.1. [O15204-2]
    NP_055294.1. NM_014479.3. [O15204-1]
    UniGeneiHs.521459.

    Genome annotation databases

    EnsembliENST00000256412; ENSP00000256412; ENSG00000134028. [O15204-1]
    ENST00000522298; ENSP00000428993; ENSG00000134028. [O15204-2]
    GeneIDi27299.
    KEGGihsa:27299.
    UCSCiuc003xdz.2. human. [O15204-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13323 mRNA. Translation: CAA73764.2 .
    AK316320 mRNA. Translation: BAH14691.1 .
    AK316322 mRNA. Translation: BAH14693.1 .
    AC120193 Genomic DNA. No translation available.
    BC069582 mRNA. Translation: AAH69582.1 .
    BC074877 mRNA. Translation: AAH74877.1 .
    BC074878 mRNA. Translation: AAH74878.1 .
    CCDSi CCDS55212.1. [O15204-2 ]
    CCDS6044.1. [O15204-1 ]
    RefSeqi NP_001138743.1. NM_001145271.1. [O15204-2 ]
    NP_001138744.1. NM_001145272.1. [O15204-2 ]
    NP_055294.1. NM_014479.3. [O15204-1 ]
    UniGenei Hs.521459.

    3D structure databases

    ProteinModelPortali O15204.
    SMRi O15204. Positions 218-461.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O15204. 1 interaction.
    STRINGi 9606.ENSP00000256412.

    Protein family/group databases

    MEROPSi M12.219.

    PTM databases

    PhosphoSitei O15204.

    Proteomic databases

    PaxDbi O15204.
    PeptideAtlasi O15204.
    PRIDEi O15204.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256412 ; ENSP00000256412 ; ENSG00000134028 . [O15204-1 ]
    ENST00000522298 ; ENSP00000428993 ; ENSG00000134028 . [O15204-2 ]
    GeneIDi 27299.
    KEGGi hsa:27299.
    UCSCi uc003xdz.2. human. [O15204-1 ]

    Organism-specific databases

    CTDi 27299.
    GeneCardsi GC08P024297.
    HGNCi HGNC:16299. ADAMDEC1.
    HPAi HPA028317.
    MIMi 606393. gene.
    neXtProti NX_O15204.
    PharmGKBi PA24535.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG280097.
    HOGENOMi HOG000230883.
    HOVERGENi HBG106501.
    InParanoidi O15204.
    KOi K08634.
    OMAi LRGYFTH.
    OrthoDBi EOG7CNZFH.
    PhylomeDBi O15204.
    TreeFami TF314733.

    Miscellaneous databases

    ChiTaRSi ADAMDEC1. human.
    GenomeRNAii 27299.
    NextBioi 50277.
    PROi O15204.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15204.
    Bgeei O15204.
    CleanExi HS_ADAMDEC1.
    Genevestigatori O15204.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    InterProi IPR001762. Blood-coag_inhib_Disintegrin.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view ]
    Pfami PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view ]
    SMARTi SM00050. DISIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57552. SSF57552. 1 hit.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells."
      Mueller C.G.F., Rissoan M.C., Salinas B., Ait-Yahia S., Ravel O., Bridon J.-M., Briere F., Lebecque S., Liu Y.J.
      J. Exp. Med. 186:655-663(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Small intestine.
    3. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    5. "Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation."
      Fritsche J., Muller A., Hausmann M., Rogler G., Andreesen R., Kreutz M.
      Immunology 110:450-457(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-237.
      Tissue: Plasma.
    7. Cited for: GLYCOSYLATION AT ASN-184.

    Entry informationi

    Entry nameiADEC1_HUMAN
    AccessioniPrimary (citable) accession number: O15204
    Secondary accession number(s): B7ZAK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3