O15204 (ADEC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ADAM DEC1
EC=3.4.24.-

Alternative name(s):
A disintegrin and metalloproteinase domain-like protein decysin-1
Short name=ADAM-like protein decysin-1

Gene names

Name:

ADAMDEC1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play an important role in the control of the immune response and during pregnancy By similarity.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC. Ref.1 Ref.5
Induction	Induced during DC maturation and up-regulated in response to T-cell signals. In macrophage up-regulated by bacterial lipopolysaccharides (LPS). Up-regulated by 1-alpha,25-dihydroxyvitamin D3 during differentiation of primary monocyte into macrophage. Ref.1 Ref.5
Sequence similarities	Contains 1 disintegrin domain. Contains 1 peptidase M12B domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	immune response Non-traceable author statement PubMed 12037602. Source: UniProtKB negative regulation of cell adhesion Non-traceable author statement Ref.1. Source: UniProtKB proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metalloendopeptidase activity Non-traceable author statement PubMed 12037602Ref.1. Source: UniProtKB zinc ion binding Non-traceable author statement PubMed 12037602. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O15204-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O15204-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Propeptide	31 – 205	175	Potential		PRO_0000029146
	Chain	206 – 470	265	ADAM DEC1		PRO_0000029147
Regions
	Domain	218 – 412	195	Peptidase M12B
	Domain	420 – 470	51	Disintegrin
Sites
	Active site	353	1	By similarity
	Metal binding	352	1	Zinc; catalytic By similarity
	Metal binding	356	1	Zinc; catalytic By similarity
	Metal binding	362	1	Zinc; catalytic Potential
Amino acid modifications
	Glycosylation	61	1	N-linked (GlcNAc...) Potential
	Glycosylation	184	1	N-linked (GlcNAc...) Potential
	Glycosylation	237	1	N-linked (GlcNAc...) Ref.6
	Glycosylation	466	1	N-linked (GlcNAc...) Potential
	Disulfide bond	328 ↔ 407		By similarity
	Disulfide bond	369 ↔ 374		By similarity
Natural variations
	Alternative sequence	1 – 79	79	Missing in isoform 2.		VSP_043124
	Natural variant	121	1	M → T. Corresponds to variant rs7007084 [ dbSNP | Ensembl ].		VAR_024598
	Natural variant	444	1	N → S. Corresponds to variant rs3765124 [ dbSNP | Ensembl ].		VAR_021848

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 2. Checksum: 35A454DD8A6A7E53	FASTA	470	52,775
	10 20 30 40 50 60 MLRGISQLPA VATMSWVLLP VLWLIVQTQA IAIKQTPELT LHEIVCPKKL HILHKREIKN 70 80 90 100 110 120 NQTEKHGKEE RYEPEVQYQM ILNGEEIILS LQKTKHLLGP DYTETLYSPR GEEITTKPEN 130 140 150 160 170 180 MEHCYYKGNI LNEKNSVASI STCDGLRGYF THHHQRYQIK PLKSTDEKEH AVFTSNQEEQ 190 200 210 220 230 240 DPANHTCGVK STDGKQGPIR ISRSLKSPEK EDFLRAQKYI DLYLVLDNAF YKNYNENLTL 250 260 270 280 290 300 IRSFVFDVMN LLNVIYNTID VQVALVGMEI WSDGDKIKVV PSASTTFDNF LRWHSSNLGK 310 320 330 340 350 360 KIHDHAQLLS GISFNNRRVG LAASNSLCSP SSVAVIEAKK KNNVALVGVM SHELGHVLGM 370 380 390 400 410 420 PDVPFNTKCP SGSCVMNQYL SSKFPKDFST SCRAHFERYL LSQKPKCLLQ APIPTNIMTT 430 440 450 460 470 PVCGNHLLEV GEDCDCGSPK ECTNLCCEAL TCKLKPGTDC GGDAPNHTTE
	Isoform 2 [UniParc]. Checksum: 68CF640D7B6A71D8	FASTA	391	43,557
	10 20 30 40 50 60 MILNGEEIIL SLQKTKHLLG PDYTETLYSP RGEEITTKPE NMEHCYYKGN ILNEKNSVAS 70 80 90 100 110 120 ISTCDGLRGY FTHHHQRYQI KPLKSTDEKE HAVFTSNQEE QDPANHTCGV KSTDGKQGPI 130 140 150 160 170 180 RISRSLKSPE KEDFLRAQKY IDLYLVLDNA FYKNYNENLT LIRSFVFDVM NLLNVIYNTI 190 200 210 220 230 240 DVQVALVGME IWSDGDKIKV VPSASTTFDN FLRWHSSNLG KKIHDHAQLL SGISFNNRRV 250 260 270 280 290 300 GLAASNSLCS PSSVAVIEAK KKNNVALVGV MSHELGHVLG MPDVPFNTKC PSGSCVMNQY 310 320 330 340 350 360 LSSKFPKDFS TSCRAHFERY LLSQKPKCLL QAPIPTNIMT TPVCGNHLLE VGEDCDCGSP 370 380 390 KECTNLCCEA LTCKLKPGTD CGGDAPNHTT E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells." Mueller C.G.F., Rissoan M.C., Salinas B., Ait-Yahia S., Ravel O., Bridon J.-M., Briere F., Lebecque S., Liu Y.J. J. Exp. Med. 186:655-663(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Small intestine.
[3]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[5]	"Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation." Fritsche J., Muller A., Hausmann M., Rogler G., Andreesen R., Kreutz M. Immunology 110:450-457(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INDUCTION.
[6]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-237, MASS SPECTROMETRY. Tissue: Plasma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y13323 mRNA. Translation: CAA73764.2. AK316320 mRNA. Translation: BAH14691.1. AK316322 mRNA. Translation: BAH14693.1. AC120193 Genomic DNA. No translation available. BC069582 mRNA. Translation: AAH69582.1. BC074877 mRNA. Translation: AAH74877.1. BC074878 mRNA. Translation: AAH74878.1.
IPI	IPI00004480. IPI00922737.
RefSeq	NP_001138743.1. NM_001145271.1. NP_001138744.1. NM_001145272.1. NP_055294.1. NM_014479.3.
UniGene	Hs.521459.
3D structure databases
ProteinModelPortal	O15204.
ModBase	Search...
Protein-protein interaction databases
IntAct	O15204. 1 interaction.
STRING	9606.ENSP00000256412.
Protein family/group databases
MEROPS	M12.219.
PTM databases
PhosphoSite	O15204.
Proteomic databases
PaxDb	O15204.
PeptideAtlas	O15204.
PRIDE	O15204.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000256412; ENSP00000256412; ENSG00000134028. ENST00000522298; ENSP00000428993; ENSG00000134028. ENST00000538205; ENSP00000442592; ENSG00000134028.
GeneID	27299.
KEGG	hsa:27299.
UCSC	uc003xdz.2. human.
Organism-specific databases
CTD	27299.
GeneCards	GC08P024297.
HGNC	HGNC:16299. ADAMDEC1.
HPA	HPA028317.
MIM	606393. gene.
neXtProt	NX_O15204.
PharmGKB	PA24535.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG280097.
HOGENOM	HOG000230883.
HOVERGEN	HBG106501.
InParanoid	O15204.
KO	K08634.
OMA	LRGYFTH.
OrthoDB	EOG4F1X36.
PhylomeDB	O15204.
Gene expression databases
ArrayExpress	O15204.
Bgee	O15204.
CleanEx	HS_ADAMDEC1.
Genevestigator	O15204.
GermOnline	ENSG00000134028. Homo sapiens.
Family and domain databases
Gene3D	3.40.390.10. 1 hit.
InterPro	IPR001762. Blood-coag_inhib_Disintegrin. IPR024079. MetalloPept_cat_dom. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. [Graphical view]
Pfam	PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. [Graphical view]
SMART	SM00050. DISIN. 1 hit. [Graphical view]
PROSITE	PS50215. ADAM_MEPRO. 1 hit. PS00546. CYSTEINE_SWITCH. False negative. PS00427. DISINTEGRIN_1. False negative. PS50214. DISINTEGRIN_2. 1 hit. PS00142. ZINC_PROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ADAMDEC1. human.
GenomeRNAi	27299.
NextBio	50277.
SOURCE	Search...

Entry information

Entry name

ADEC1_HUMAN

Accession

Primary (citable) accession number: O15204
Secondary accession number(s): B7ZAK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.