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O15204

- ADEC1_HUMAN

UniProt

O15204 - ADEC1_HUMAN

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Protein

ADAM DEC1

Gene

ADAMDEC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play an important role in the control of the immune response and during pregnancy.By similarity

Cofactori

Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi352 – 3521Zinc; catalyticBy similarity
Active sitei353 – 3531PROSITE-ProRule annotation
Metal bindingi356 – 3561Zinc; catalyticBy similarity
Metal bindingi362 – 3621Zinc; catalyticSequence Analysis

GO - Molecular functioni

  1. metalloendopeptidase activity Source: UniProtKB
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. immune response Source: UniProtKB
  2. negative regulation of cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.219.

Names & Taxonomyi

Protein namesi
Recommended name:
ADAM DEC1 (EC:3.4.24.-)
Alternative name(s):
A disintegrin and metalloproteinase domain-like protein decysin-1
Short name:
ADAM-like protein decysin-1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:16299. ADAMDEC1.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Propeptidei31 – 205175Sequence AnalysisPRO_0000029146Add
BLAST
Chaini206 – 470265ADAM DEC1PRO_0000029147Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi184 – 1841N-linked (GlcNAc...) (complex)1 Publication
Glycosylationi237 – 2371N-linked (GlcNAc...)1 Publication
Disulfide bondi328 ↔ 407By similarity
Disulfide bondi369 ↔ 374By similarity
Glycosylationi466 – 4661N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiO15204.
PeptideAtlasiO15204.
PRIDEiO15204.

PTM databases

PhosphoSiteiO15204.

Expressioni

Tissue specificityi

Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC.2 Publications

Inductioni

Induced during DC maturation and up-regulated in response to T-cell signals. In macrophage up-regulated by bacterial lipopolysaccharides (LPS). Up-regulated by 1-alpha,25-dihydroxyvitamin D3 during differentiation of primary monocyte into macrophage.2 Publications

Gene expression databases

BgeeiO15204.
CleanExiHS_ADAMDEC1.
ExpressionAtlasiO15204. baseline and differential.
GenevestigatoriO15204.

Organism-specific databases

HPAiHPA028317.

Interactioni

Protein-protein interaction databases

IntActiO15204. 1 interaction.
STRINGi9606.ENSP00000256412.

Structurei

3D structure databases

ProteinModelPortaliO15204.
SMRiO15204. Positions 218-461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini218 – 412195Peptidase M12BPROSITE-ProRule annotationAdd
BLAST
Domaini420 – 47051DisintegrinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG280097.
GeneTreeiENSGT00760000119181.
HOGENOMiHOG000230883.
HOVERGENiHBG106501.
InParanoidiO15204.
KOiK08634.
OMAiLRGYFTH.
OrthoDBiEOG7CNZFH.
PhylomeDBiO15204.
TreeFamiTF314733.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR001762. Blood-coag_inhib_Disintegrin.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
SMARTiSM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O15204) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRGISQLPA VATMSWVLLP VLWLIVQTQA IAIKQTPELT LHEIVCPKKL
60 70 80 90 100
HILHKREIKN NQTEKHGKEE RYEPEVQYQM ILNGEEIILS LQKTKHLLGP
110 120 130 140 150
DYTETLYSPR GEEITTKPEN MEHCYYKGNI LNEKNSVASI STCDGLRGYF
160 170 180 190 200
THHHQRYQIK PLKSTDEKEH AVFTSNQEEQ DPANHTCGVK STDGKQGPIR
210 220 230 240 250
ISRSLKSPEK EDFLRAQKYI DLYLVLDNAF YKNYNENLTL IRSFVFDVMN
260 270 280 290 300
LLNVIYNTID VQVALVGMEI WSDGDKIKVV PSASTTFDNF LRWHSSNLGK
310 320 330 340 350
KIHDHAQLLS GISFNNRRVG LAASNSLCSP SSVAVIEAKK KNNVALVGVM
360 370 380 390 400
SHELGHVLGM PDVPFNTKCP SGSCVMNQYL SSKFPKDFST SCRAHFERYL
410 420 430 440 450
LSQKPKCLLQ APIPTNIMTT PVCGNHLLEV GEDCDCGSPK ECTNLCCEAL
460 470
TCKLKPGTDC GGDAPNHTTE
Length:470
Mass (Da):52,775
Last modified:November 1, 1999 - v2
Checksum:i35A454DD8A6A7E53
GO
Isoform 2 (identifier: O15204-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Note: No experimental confirmation available.

Show »
Length:391
Mass (Da):43,557
Checksum:i68CF640D7B6A71D8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211M → T.
Corresponds to variant rs7007084 [ dbSNP | Ensembl ].
VAR_024598
Natural varianti444 – 4441N → S.
Corresponds to variant rs3765124 [ dbSNP | Ensembl ].
VAR_021848

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7979Missing in isoform 2. 1 PublicationVSP_043124Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13323 mRNA. Translation: CAA73764.2.
AK316320 mRNA. Translation: BAH14691.1.
AK316322 mRNA. Translation: BAH14693.1.
AC120193 Genomic DNA. No translation available.
BC069582 mRNA. Translation: AAH69582.1.
BC074877 mRNA. Translation: AAH74877.1.
BC074878 mRNA. Translation: AAH74878.1.
CCDSiCCDS55212.1. [O15204-2]
CCDS6044.1. [O15204-1]
RefSeqiNP_001138743.1. NM_001145271.1. [O15204-2]
NP_001138744.1. NM_001145272.1. [O15204-2]
NP_055294.1. NM_014479.3. [O15204-1]
UniGeneiHs.521459.

Genome annotation databases

EnsembliENST00000256412; ENSP00000256412; ENSG00000134028. [O15204-1]
ENST00000522298; ENSP00000428993; ENSG00000134028. [O15204-2]
GeneIDi27299.
KEGGihsa:27299.
UCSCiuc003xdz.2. human. [O15204-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13323 mRNA. Translation: CAA73764.2 .
AK316320 mRNA. Translation: BAH14691.1 .
AK316322 mRNA. Translation: BAH14693.1 .
AC120193 Genomic DNA. No translation available.
BC069582 mRNA. Translation: AAH69582.1 .
BC074877 mRNA. Translation: AAH74877.1 .
BC074878 mRNA. Translation: AAH74878.1 .
CCDSi CCDS55212.1. [O15204-2 ]
CCDS6044.1. [O15204-1 ]
RefSeqi NP_001138743.1. NM_001145271.1. [O15204-2 ]
NP_001138744.1. NM_001145272.1. [O15204-2 ]
NP_055294.1. NM_014479.3. [O15204-1 ]
UniGenei Hs.521459.

3D structure databases

ProteinModelPortali O15204.
SMRi O15204. Positions 218-461.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O15204. 1 interaction.
STRINGi 9606.ENSP00000256412.

Protein family/group databases

MEROPSi M12.219.

PTM databases

PhosphoSitei O15204.

Proteomic databases

PaxDbi O15204.
PeptideAtlasi O15204.
PRIDEi O15204.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256412 ; ENSP00000256412 ; ENSG00000134028 . [O15204-1 ]
ENST00000522298 ; ENSP00000428993 ; ENSG00000134028 . [O15204-2 ]
GeneIDi 27299.
KEGGi hsa:27299.
UCSCi uc003xdz.2. human. [O15204-1 ]

Organism-specific databases

CTDi 27299.
GeneCardsi GC08P024241.
HGNCi HGNC:16299. ADAMDEC1.
HPAi HPA028317.
MIMi 606393. gene.
neXtProti NX_O15204.
PharmGKBi PA24535.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG280097.
GeneTreei ENSGT00760000119181.
HOGENOMi HOG000230883.
HOVERGENi HBG106501.
InParanoidi O15204.
KOi K08634.
OMAi LRGYFTH.
OrthoDBi EOG7CNZFH.
PhylomeDBi O15204.
TreeFami TF314733.

Miscellaneous databases

ChiTaRSi ADAMDEC1. human.
GenomeRNAii 27299.
NextBioi 50277.
PROi O15204.
SOURCEi Search...

Gene expression databases

Bgeei O15204.
CleanExi HS_ADAMDEC1.
ExpressionAtlasi O15204. baseline and differential.
Genevestigatori O15204.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
InterProi IPR001762. Blood-coag_inhib_Disintegrin.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view ]
Pfami PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view ]
SMARTi SM00050. DISIN. 1 hit.
[Graphical view ]
SUPFAMi SSF57552. SSF57552. 1 hit.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells."
    Mueller C.G.F., Rissoan M.C., Salinas B., Ait-Yahia S., Ravel O., Bridon J.-M., Briere F., Lebecque S., Liu Y.J.
    J. Exp. Med. 186:655-663(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Small intestine.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  5. "Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation."
    Fritsche J., Muller A., Hausmann M., Rogler G., Andreesen R., Kreutz M.
    Immunology 110:450-457(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-237.
    Tissue: Plasma.
  7. Cited for: GLYCOSYLATION AT ASN-184.

Entry informationi

Entry nameiADEC1_HUMAN
AccessioniPrimary (citable) accession number: O15204
Secondary accession number(s): B7ZAK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3