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Protein

Ephrin type-B receptor 6

Gene

EPHB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi676 – 684ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ephrin receptor activity Source: ProtInc
  • receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106123-MONOMER.
ReactomeiR-HSA-2682334. EPH-Ephrin signaling.
R-HSA-3928662. EPHB-mediated forward signaling.
R-HSA-3928664. Ephrin signaling.
R-HSA-3928665. EPH-ephrin mediated repulsion of cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-B receptor 6
Alternative name(s):
HEP
Tyrosine-protein kinase-defective receptor EPH-6
Gene namesi
Name:EPHB6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:3396. EPHB6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 594ExtracellularSequence analysisAdd BLAST563
Transmembranei595 – 615HelicalSequence analysisAdd BLAST21
Topological domaini616 – 1021CytoplasmicSequence analysisAdd BLAST406

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2051.
PharmGKBiPA27828.

Chemistry databases

ChEMBLiCHEMBL5836.
GuidetoPHARMACOLOGYi1834.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 311 PublicationAdd BLAST31
ChainiPRO_000001683732 – 1021Ephrin type-B receptor 6Add BLAST990

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi480N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO15197.
PeptideAtlasiO15197.
PRIDEiO15197.

PTM databases

iPTMnetiO15197.
PhosphoSitePlusiO15197.

Expressioni

Tissue specificityi

Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.3 Publications

Gene expression databases

BgeeiENSG00000106123.
CleanExiHS_EPHB6.

Organism-specific databases

HPAiHPA035784.

Interactioni

Subunit structurei

Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent manner.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
INCA1Q0VD865EBI-10182490,EBI-6509505
NIF3L1Q9GZT83EBI-10182490,EBI-740897
NOTCH2NLQ7Z3S93EBI-10182490,EBI-945833
RELQ048643EBI-10182490,EBI-307352
TCF4P158843EBI-10182490,EBI-533224
TRIM39Q9HCM93EBI-10182490,EBI-739510

Protein-protein interaction databases

BioGridi108365. 11 interactors.
IntActiO15197. 16 interactors.
MINTiMINT-1392963.
STRINGi9606.ENSP00000376684.

Chemistry databases

BindingDBiO15197.

Structurei

3D structure databases

ProteinModelPortaliO15197.
SMRiO15197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 237Eph LBDPROSITE-ProRule annotationAdd BLAST205
Domaini369 – 486Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST118
Domaini487 – 582Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini670 – 919Protein kinasePROSITE-ProRule annotationAdd BLAST250
Domaini948 – 1012SAMPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1019 – 1021PDZ-bindingSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi166 – 176Poly-SerAdd BLAST11
Compositional biasi219 – 366Cys-richAdd BLAST148
Compositional biasi881 – 884Poly-Pro4

Domaini

The protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable of promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic domain is essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation
Contains 1 Eph LBD (Eph ligand-binding) domain.PROSITE-ProRule annotation
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiO15197.
KOiK05114.
PhylomeDBiO15197.
TreeFamiTF314013.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15197-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATEGAAQLG NRVAGMVCSL WVLLLVSSVL ALEEVLLDTT GETSEIGWLT
60 70 80 90 100
YPPGGWDEVS VLDDQRRLTR TFEACHVAGA PPGTGQDNWL QTHFVERRGA
110 120 130 140 150
QRAHIRLHFS VRACSSLGVS GGTCRETFTL YYRQAEEPDS PDSVSSWHLK
160 170 180 190 200
RWTKVDTIAA DESFPSSSSS SSSSSSAAWA VGPHGAGQRA GLQLNVKERS
210 220 230 240 250
FGPLTQRGFY VAFQDTGACL ALVAVRLFSY TCPAVLRSFA SFPETQASGA
260 270 280 290 300
GGASLVAAVG TCVAHAEPEE DGVGGQAGGS PPRLHCNGEG KWMVAVGGCR
310 320 330 340 350
CQPGYQPARG DKACQACPRG LYKSSAGNAP CSPCPARSHA PNPAAPVCPC
360 370 380 390 400
LEGFYRASSD PPEAPCTGPP SAPQELWFEV QGSALMLHWR LPRELGGRGD
410 420 430 440 450
LLFNVVCKEC EGRQEPASGG GGTCHRCRDE VHFDPRQRGL TESRVLVGGL
460 470 480 490 500
RAHVPYILEV QAVNGVSELS PDPPQAAAIN VSTSHEVPSA VPVVHQVSRA
510 520 530 540 550
SNSITVSWPQ PDQTNGNILD YQLRYYDQAE DESHSFTLTS ETNTATVTQL
560 570 580 590 600
SPGHIYGFQV RARTAAGHGP YGGKVYFQTL PQGELSSQLP ERLSLVIGSI
610 620 630 640 650
LGALAFLLLA AITVLAVVFQ RKRRGTGYTE QLQQYSSPGL GVKYYIDPST
660 670 680 690 700
YEDPCQAIRE LAREVDPAYI KIEEVIGTGS FGEVRQGRLQ PRGRREQTVA
710 720 730 740 750
IQALWAGGAE SLQMTFLGRA AVLGQFQHPN ILRLEGVVTK SRPLMVLTEF
760 770 780 790 800
MELGPLDSFL RQREGQFSSL QLVAMQRGVA AAMQYLSSFA FVHRSLSAHS
810 820 830 840 850
VLVNSHLVCK VARLGHSPQG PSCLLRWAAP EVIAHGKHTT SSDVWSFGIL
860 870 880 890 900
MWEVMSYGER PYWDMSEQEV LNAIEQEFRL PPPPGCPPGL HLLMLDTWQK
910 920 930 940 950
DRARRPHFDQ LVAAFDKMIR KPDTLQAGGD PGERPSQALL TPVALDFPCL
960 970 980 990 1000
DSPQAWLSAI GLECYQDNFS KFGLCTFSDV AQLSLEDLPA LGITLAGHQK
1010 1020
KLLHHIQLLQ QHLRQQGSVE V
Length:1,021
Mass (Da):110,700
Last modified:April 20, 2010 - v4
Checksum:iBF1D4D9BE34358A5
GO
Isoform 2 (identifier: O15197-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-292: Missing.

Show »
Length:744
Mass (Da):81,211
Checksum:i8BCF105B3B7A5B92
GO
Isoform 3 (identifier: O15197-3) [UniParc]FASTAAdd to basket
Also known as: EphB6v

The sequence of this isoform differs from the canonical sequence as follows:
     487-540: VPSAVPVVHQ...DESHSFTLTS → GELFSLAFRI...YPHNNFPFAL
     541-1021: Missing.

Show »
Length:540
Mass (Da):57,498
Checksum:i3635871D1070FF27
GO

Sequence cautioni

The sequence AAD03058 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI10608 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAP20939 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA21560 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAL23775 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAW51902 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019139122G → S.2 PublicationsCorresponds to variant rs8177173dbSNPEnsembl.1
Natural variantiVAR_042190170S → T.1 Publication1
Natural variantiVAR_042191221A → V.1 Publication1
Natural variantiVAR_042192282P → H.1 Publication1
Natural variantiVAR_019140282P → R.1 PublicationCorresponds to variant rs8177143dbSNPEnsembl.1
Natural variantiVAR_042193309R → Q.1 PublicationCorresponds to variant rs55728646dbSNPEnsembl.1
Natural variantiVAR_019141324S → A.2 PublicationsCorresponds to variant rs8177146dbSNPEnsembl.1
Natural variantiVAR_042194332S → L.1 PublicationCorresponds to variant rs35189999dbSNPEnsembl.1
Natural variantiVAR_036091360D → N in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_019142499R → Q.1 PublicationCorresponds to variant rs8177175dbSNPEnsembl.1
Natural variantiVAR_036092603A → P in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_042195662A → V.1 PublicationCorresponds to variant rs35984674dbSNPEnsembl.1
Natural variantiVAR_036093719R → Q in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_042196743P → S in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_042197813R → H.1 Publication1
Natural variantiVAR_042198875E → K in a glioblastoma multiforme sample; somatic mutation. 1 Publication1
Natural variantiVAR_036094930D → G in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_042199993I → V.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03749616 – 292Missing in isoform 2. 1 PublicationAdd BLAST277
Alternative sequenceiVSP_037497487 – 540VPSAV…FTLTS → GELFSLAFRIPCLRSFEPPS LLLISSLVHPCRPPLKADPA PRDSYPHNNFPFAL in isoform 3. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_037498541 – 1021Missing in isoform 3. 1 PublicationAdd BLAST481

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83492 mRNA. Translation: BAA21560.1. Different initiation.
AY280502 Genomic DNA. Translation: AAP20939.1. Different initiation.
AF107256 Genomic DNA. Translation: AAD03058.1. Different initiation.
AC104597 Genomic DNA. No translation available.
CH236959 Genomic DNA. Translation: EAL23775.1. Sequence problems.
CH471198 Genomic DNA. Translation: EAW51900.1.
CH471198 Genomic DNA. Translation: EAW51901.1.
CH471198 Genomic DNA. Translation: EAW51902.1. Sequence problems.
CH471198 Genomic DNA. Translation: EAW51903.1.
BC051028 mRNA. No translation available.
BC110606 mRNA. Translation: AAI10607.1.
BC110607 mRNA. Translation: AAI10608.2. Different initiation.
EU054308 mRNA. Translation: ABV55388.1.
PIRiJC5526.
RefSeqiNP_001267724.2. NM_001280795.2.
NP_004436.4. NM_004445.5.
UniGeneiHs.380089.

Genome annotation databases

EnsembliENST00000392957; ENSP00000376684; ENSG00000106123.
ENST00000442129; ENSP00000410789; ENSG00000106123.
GeneIDi2051.
KEGGihsa:2051.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83492 mRNA. Translation: BAA21560.1. Different initiation.
AY280502 Genomic DNA. Translation: AAP20939.1. Different initiation.
AF107256 Genomic DNA. Translation: AAD03058.1. Different initiation.
AC104597 Genomic DNA. No translation available.
CH236959 Genomic DNA. Translation: EAL23775.1. Sequence problems.
CH471198 Genomic DNA. Translation: EAW51900.1.
CH471198 Genomic DNA. Translation: EAW51901.1.
CH471198 Genomic DNA. Translation: EAW51902.1. Sequence problems.
CH471198 Genomic DNA. Translation: EAW51903.1.
BC051028 mRNA. No translation available.
BC110606 mRNA. Translation: AAI10607.1.
BC110607 mRNA. Translation: AAI10608.2. Different initiation.
EU054308 mRNA. Translation: ABV55388.1.
PIRiJC5526.
RefSeqiNP_001267724.2. NM_001280795.2.
NP_004436.4. NM_004445.5.
UniGeneiHs.380089.

3D structure databases

ProteinModelPortaliO15197.
SMRiO15197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108365. 11 interactors.
IntActiO15197. 16 interactors.
MINTiMINT-1392963.
STRINGi9606.ENSP00000376684.

Chemistry databases

BindingDBiO15197.
ChEMBLiCHEMBL5836.
GuidetoPHARMACOLOGYi1834.

PTM databases

iPTMnetiO15197.
PhosphoSitePlusiO15197.

Proteomic databases

PaxDbiO15197.
PeptideAtlasiO15197.
PRIDEiO15197.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392957; ENSP00000376684; ENSG00000106123.
ENST00000442129; ENSP00000410789; ENSG00000106123.
GeneIDi2051.
KEGGihsa:2051.

Organism-specific databases

CTDi2051.
DisGeNETi2051.
GeneCardsiEPHB6.
HGNCiHGNC:3396. EPHB6.
HPAiHPA035784.
MIMi602757. gene.
neXtProtiNX_O15197.
PharmGKBiPA27828.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiO15197.
KOiK05114.
PhylomeDBiO15197.
TreeFamiTF314013.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106123-MONOMER.
ReactomeiR-HSA-2682334. EPH-Ephrin signaling.
R-HSA-3928662. EPHB-mediated forward signaling.
R-HSA-3928664. Ephrin signaling.
R-HSA-3928665. EPH-ephrin mediated repulsion of cells.

Miscellaneous databases

ChiTaRSiEPHB6. human.
GeneWikiiEPHB6.
GenomeRNAii2051.
PROiO15197.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106123.
CleanExiHS_EPHB6.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEPHB6_HUMAN
AccessioniPrimary (citable) accession number: O15197
Secondary accession number(s): A4D2I7
, A8CDT5, D3DXD3, Q2TB23, Q2TB24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 180 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.