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O15195

- VILL_HUMAN

UniProt

O15195 - VILL_HUMAN

Protein

Villin-like protein

Gene

VILL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 3 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Possible tumor suppressor.

    GO - Molecular functioni

    1. structural constituent of cytoskeleton Source: ProtInc

    GO - Biological processi

    1. actin filament capping Source: UniProtKB-KW
    2. cytoskeleton organization Source: InterPro

    Keywords - Molecular functioni

    Actin capping

    Keywords - Ligandi

    Actin-binding, Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Villin-like protein
    Gene namesi
    Name:VILL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30906. VILL.

    Subcellular locationi

    GO - Cellular componenti

    1. actin cytoskeleton Source: ProtInc

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134911684.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 856856Villin-like proteinPRO_0000218738Add
    BLAST

    Proteomic databases

    MaxQBiO15195.
    PaxDbiO15195.
    PRIDEiO15195.

    PTM databases

    PhosphoSiteiO15195.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed in 16 tissues examined.

    Gene expression databases

    ArrayExpressiO15195.
    BgeeiO15195.
    CleanExiHS_VILL.
    GenevestigatoriO15195.

    Organism-specific databases

    HPAiHPA035675.
    HPA035676.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000283713.

    Structurei

    3D structure databases

    ProteinModelPortaliO15195.
    SMRiO15195. Positions 9-714, 801-856.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati22 – 7453Gelsolin-like 1Add
    BLAST
    Repeati146 – 18641Gelsolin-like 2Add
    BLAST
    Repeati263 – 30745Gelsolin-like 3Add
    BLAST
    Repeati401 – 45050Gelsolin-like 4Add
    BLAST
    Repeati521 – 56141Gelsolin-like 5Add
    BLAST
    Repeati624 – 66542Gelsolin-like 6Add
    BLAST
    Domaini790 – 85667HPPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the villin/gelsolin family.Curated
    Contains 6 gelsolin-like repeats.Curated
    Contains 1 HP (headpiece) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG304849.
    HOGENOMiHOG000233630.
    HOVERGENiHBG004183.
    InParanoidiO15195.
    OMAiPERAYGN.
    OrthoDBiEOG7288RJ.
    PhylomeDBiO15195.
    TreeFamiTF313468.

    Family and domain databases

    Gene3Di1.10.950.10. 1 hit.
    3.40.20.10. 6 hits.
    InterProiIPR029006. ADF-H/Gelsolin-like_dom.
    IPR007123. Gelsolin-like_dom.
    IPR015626. Villin-like.
    IPR007122. Villin/Gelsolin.
    IPR003128. Villin_headpiece.
    [Graphical view]
    PANTHERiPTHR11977. PTHR11977. 1 hit.
    PTHR11977:SF30. PTHR11977:SF30. 1 hit.
    PfamiPF00626. Gelsolin. 6 hits.
    PF02209. VHP. 1 hit.
    [Graphical view]
    PRINTSiPR00597. GELSOLIN.
    SMARTiSM00262. GEL. 6 hits.
    SM00153. VHP. 1 hit.
    [Graphical view]
    SUPFAMiSSF47050. SSF47050. 1 hit.
    PROSITEiPS51089. HP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O15195-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDISKGLPGM QGGLHIWISE NRKMVPVPEG AYGNFFEEHC YVILHVPQSP    50
    KATQGASSDL HYWVGKQAGA EAQGAAEAFQ QRLQDELGGQ TVLHREAQGH 100
    ESDCFCSYFR PGIIYRKGGL ASDLKHVETN LFNIQRLLHI KGRKHVSATE 150
    VELSWNSFNK GDIFLLDLGK MMIQWNGPKT SISEKARGLA LTYSLRDRER 200
    GGGRAQIGVV DDEAKAPDLM QIMEAVLGRR VGSLRAATPS KDINQLQKAN 250
    VRLYHVYEKG KDLVVLELAT PPLTQDLLQE EDFYILDQGG FKIYVWQGRM 300
    SSLQERKAAF SRAVGFIQAK GYPTYTNVEV VNDGAESAAF KQLFRTWSEK 350
    RRRNQKLGGR DKSIHVKLDV GKLHTQPKLA AQLRMVDDGS GKVEVWCIQD 400
    LHRQPVDPKR HGQLCAGNCY LVLYTYQRLG RVQYILYLWQ GHQATADEIE 450
    ALNSNAEELD VMYGGVLVQE HVTMGSEPPH FLAIFQGQLV IFQERAGHHG 500
    KGQSASTTRL FQVQGTDSHN TRTMEVPARA SSLNSSDIFL LVTASVCYLW 550
    FGKGCNGDQR EMARVVVTVI SRKNEETVLE GQEPPHFWEA LGGRAPYPSN 600
    KRLPEEVPSF QPRLFECSSH MGCLVLAEVG FFSQEDLDKY DIMLLDTWQE 650
    IFLWLGEAAS EWKEAVAWGQ EYLKTHPAGR SPATPIVLVK QGHEPPTFIG 700
    WFFTWDPYKW TSHPSHKEVV DGSPAAASTI SEITAEVNNL RLSRWPGNGR 750
    AGAVALQALK GSQDSSENDL VRSPKSAGSR TSSSVSSTSA TINGGLRREQ 800
    LMHQAVEDLP EGVDPARREF YLSDSDFQDI FGKSKEEFYS MATWRQRQEK 850
    KQLGFF 856
    Length:856
    Mass (Da):95,907
    Last modified:March 15, 2005 - v3
    Checksum:iA8B7EDEFDF11CEE1
    GO
    Isoform 2 (identifier: O15195-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         262-275: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:842
    Mass (Da):94,417
    Checksum:i2642A8BB552C2788
    GO

    Sequence cautioni

    The sequence AAH00243.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH04300.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti229 – 2291R → C in BAA21668. (PubMed:9179494)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti610 – 6101F → L.
    Corresponds to variant rs1892814 [ dbSNP | Ensembl ].
    VAR_052938
    Natural varianti740 – 7401L → F.
    Corresponds to variant rs9816693 [ dbSNP | Ensembl ].
    VAR_052939

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei262 – 27514Missing in isoform 2. 1 PublicationVSP_006729Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC105752 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64506.1.
    BC000243 mRNA. Translation: AAH00243.1. Different initiation.
    BC004300 mRNA. Translation: AAH04300.1. Different initiation.
    D88154 mRNA. Translation: BAA21668.1.
    CCDSiCCDS2670.2. [O15195-1]
    PIRiJC5708.
    RefSeqiNP_056957.3. NM_015873.3. [O15195-1]
    XP_005265248.1. XM_005265191.1. [O15195-1]
    XP_005265249.1. XM_005265192.2. [O15195-1]
    XP_006713246.1. XM_006713183.1. [O15195-1]
    XP_006713247.1. XM_006713184.1. [O15195-1]
    XP_006713248.1. XM_006713185.1.
    UniGeneiHs.103665.

    Genome annotation databases

    EnsembliENST00000283713; ENSP00000283713; ENSG00000136059. [O15195-1]
    ENST00000383759; ENSP00000373266; ENSG00000136059. [O15195-1]
    GeneIDi50853.
    KEGGihsa:50853.
    UCSCiuc003chj.3. human. [O15195-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC105752 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64506.1 .
    BC000243 mRNA. Translation: AAH00243.1 . Different initiation.
    BC004300 mRNA. Translation: AAH04300.1 . Different initiation.
    D88154 mRNA. Translation: BAA21668.1 .
    CCDSi CCDS2670.2. [O15195-1 ]
    PIRi JC5708.
    RefSeqi NP_056957.3. NM_015873.3. [O15195-1 ]
    XP_005265248.1. XM_005265191.1. [O15195-1 ]
    XP_005265249.1. XM_005265192.2. [O15195-1 ]
    XP_006713246.1. XM_006713183.1. [O15195-1 ]
    XP_006713247.1. XM_006713184.1. [O15195-1 ]
    XP_006713248.1. XM_006713185.1.
    UniGenei Hs.103665.

    3D structure databases

    ProteinModelPortali O15195.
    SMRi O15195. Positions 9-714, 801-856.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000283713.

    PTM databases

    PhosphoSitei O15195.

    Proteomic databases

    MaxQBi O15195.
    PaxDbi O15195.
    PRIDEi O15195.

    Protocols and materials databases

    DNASUi 50853.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000283713 ; ENSP00000283713 ; ENSG00000136059 . [O15195-1 ]
    ENST00000383759 ; ENSP00000373266 ; ENSG00000136059 . [O15195-1 ]
    GeneIDi 50853.
    KEGGi hsa:50853.
    UCSCi uc003chj.3. human. [O15195-1 ]

    Organism-specific databases

    CTDi 50853.
    GeneCardsi GC03P038029.
    H-InvDB HIX0200527.
    HGNCi HGNC:30906. VILL.
    HPAi HPA035675.
    HPA035676.
    neXtProti NX_O15195.
    PharmGKBi PA134911684.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304849.
    HOGENOMi HOG000233630.
    HOVERGENi HBG004183.
    InParanoidi O15195.
    OMAi PERAYGN.
    OrthoDBi EOG7288RJ.
    PhylomeDBi O15195.
    TreeFami TF313468.

    Miscellaneous databases

    ChiTaRSi VILL. human.
    GenomeRNAii 50853.
    NextBioi 53327.
    PROi O15195.

    Gene expression databases

    ArrayExpressi O15195.
    Bgeei O15195.
    CleanExi HS_VILL.
    Genevestigatori O15195.

    Family and domain databases

    Gene3Di 1.10.950.10. 1 hit.
    3.40.20.10. 6 hits.
    InterProi IPR029006. ADF-H/Gelsolin-like_dom.
    IPR007123. Gelsolin-like_dom.
    IPR015626. Villin-like.
    IPR007122. Villin/Gelsolin.
    IPR003128. Villin_headpiece.
    [Graphical view ]
    PANTHERi PTHR11977. PTHR11977. 1 hit.
    PTHR11977:SF30. PTHR11977:SF30. 1 hit.
    Pfami PF00626. Gelsolin. 6 hits.
    PF02209. VHP. 1 hit.
    [Graphical view ]
    PRINTSi PR00597. GELSOLIN.
    SMARTi SM00262. GEL. 6 hits.
    SM00153. VHP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47050. SSF47050. 1 hit.
    PROSITEi PS51089. HP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-856 (ISOFORM 1).
      Tissue: Eye and Pancreas.
    4. "Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line."
      Ishikawa S., Kai M., Tamari M., Takei Y., Takeuchi K., Bandou H., Yamane Y., Ogawa M., Nakamura Y.
      DNA Res. 4:35-43(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 171-856 (ISOFORM 1).
      Tissue: Fetal brain, Lung and Pancreas.

    Entry informationi

    Entry nameiVILL_HUMAN
    AccessioniPrimary (citable) accession number: O15195
    Secondary accession number(s): A8MZP1, Q9BT80, Q9BWH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 123 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3