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O15195

- VILL_HUMAN

UniProt

O15195 - VILL_HUMAN

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Protein

Villin-like protein

Gene

VILL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Possible tumor suppressor.

GO - Molecular functioni

  1. structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

  1. actin filament capping Source: UniProtKB-KW
  2. cytoskeleton organization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Ligandi

Actin-binding, Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Villin-like protein
Gene namesi
Name:VILL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30906. VILL.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134911684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 856856Villin-like proteinPRO_0000218738Add
BLAST

Proteomic databases

MaxQBiO15195.
PaxDbiO15195.
PRIDEiO15195.

PTM databases

PhosphoSiteiO15195.

Expressioni

Tissue specificityi

Ubiquitously expressed in 16 tissues examined.

Gene expression databases

BgeeiO15195.
CleanExiHS_VILL.
ExpressionAtlasiO15195. baseline and differential.
GenevestigatoriO15195.

Organism-specific databases

HPAiHPA035675.
HPA035676.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000283713.

Structurei

3D structure databases

ProteinModelPortaliO15195.
SMRiO15195. Positions 9-714, 801-856.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati22 – 7453Gelsolin-like 1Add
BLAST
Repeati146 – 18641Gelsolin-like 2Add
BLAST
Repeati263 – 30745Gelsolin-like 3Add
BLAST
Repeati401 – 45050Gelsolin-like 4Add
BLAST
Repeati521 – 56141Gelsolin-like 5Add
BLAST
Repeati624 – 66542Gelsolin-like 6Add
BLAST
Domaini790 – 85667HPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated
Contains 6 gelsolin-like repeats.Curated
Contains 1 HP (headpiece) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG304849.
GeneTreeiENSGT00760000119111.
HOGENOMiHOG000233630.
HOVERGENiHBG004183.
InParanoidiO15195.
OMAiPERAYGN.
OrthoDBiEOG7288RJ.
PhylomeDBiO15195.
TreeFamiTF313468.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
3.40.20.10. 6 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR015626. Villin-like.
IPR007122. Villin/Gelsolin.
IPR003128. Villin_headpiece.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF30. PTHR11977:SF30. 1 hit.
PfamiPF00626. Gelsolin. 6 hits.
PF02209. VHP. 1 hit.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
PROSITEiPS51089. HP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O15195-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDISKGLPGM QGGLHIWISE NRKMVPVPEG AYGNFFEEHC YVILHVPQSP
60 70 80 90 100
KATQGASSDL HYWVGKQAGA EAQGAAEAFQ QRLQDELGGQ TVLHREAQGH
110 120 130 140 150
ESDCFCSYFR PGIIYRKGGL ASDLKHVETN LFNIQRLLHI KGRKHVSATE
160 170 180 190 200
VELSWNSFNK GDIFLLDLGK MMIQWNGPKT SISEKARGLA LTYSLRDRER
210 220 230 240 250
GGGRAQIGVV DDEAKAPDLM QIMEAVLGRR VGSLRAATPS KDINQLQKAN
260 270 280 290 300
VRLYHVYEKG KDLVVLELAT PPLTQDLLQE EDFYILDQGG FKIYVWQGRM
310 320 330 340 350
SSLQERKAAF SRAVGFIQAK GYPTYTNVEV VNDGAESAAF KQLFRTWSEK
360 370 380 390 400
RRRNQKLGGR DKSIHVKLDV GKLHTQPKLA AQLRMVDDGS GKVEVWCIQD
410 420 430 440 450
LHRQPVDPKR HGQLCAGNCY LVLYTYQRLG RVQYILYLWQ GHQATADEIE
460 470 480 490 500
ALNSNAEELD VMYGGVLVQE HVTMGSEPPH FLAIFQGQLV IFQERAGHHG
510 520 530 540 550
KGQSASTTRL FQVQGTDSHN TRTMEVPARA SSLNSSDIFL LVTASVCYLW
560 570 580 590 600
FGKGCNGDQR EMARVVVTVI SRKNEETVLE GQEPPHFWEA LGGRAPYPSN
610 620 630 640 650
KRLPEEVPSF QPRLFECSSH MGCLVLAEVG FFSQEDLDKY DIMLLDTWQE
660 670 680 690 700
IFLWLGEAAS EWKEAVAWGQ EYLKTHPAGR SPATPIVLVK QGHEPPTFIG
710 720 730 740 750
WFFTWDPYKW TSHPSHKEVV DGSPAAASTI SEITAEVNNL RLSRWPGNGR
760 770 780 790 800
AGAVALQALK GSQDSSENDL VRSPKSAGSR TSSSVSSTSA TINGGLRREQ
810 820 830 840 850
LMHQAVEDLP EGVDPARREF YLSDSDFQDI FGKSKEEFYS MATWRQRQEK

KQLGFF
Length:856
Mass (Da):95,907
Last modified:March 15, 2005 - v3
Checksum:iA8B7EDEFDF11CEE1
GO
Isoform 2 (identifier: O15195-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-275: Missing.

Note: No experimental confirmation available.

Show »
Length:842
Mass (Da):94,417
Checksum:i2642A8BB552C2788
GO

Sequence cautioni

The sequence AAH00243.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH04300.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti229 – 2291R → C in BAA21668. (PubMed:9179494)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti610 – 6101F → L.
Corresponds to variant rs1892814 [ dbSNP | Ensembl ].
VAR_052938
Natural varianti740 – 7401L → F.
Corresponds to variant rs9816693 [ dbSNP | Ensembl ].
VAR_052939

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei262 – 27514Missing in isoform 2. 1 PublicationVSP_006729Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC105752 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64506.1.
BC000243 mRNA. Translation: AAH00243.1. Different initiation.
BC004300 mRNA. Translation: AAH04300.1. Different initiation.
D88154 mRNA. Translation: BAA21668.1.
CCDSiCCDS2670.2. [O15195-1]
PIRiJC5708.
RefSeqiNP_056957.3. NM_015873.3. [O15195-1]
XP_005265248.1. XM_005265191.1. [O15195-1]
XP_005265249.1. XM_005265192.2. [O15195-1]
XP_006713246.1. XM_006713183.1. [O15195-1]
XP_006713247.1. XM_006713184.1. [O15195-1]
XP_006713248.1. XM_006713185.1.
UniGeneiHs.103665.

Genome annotation databases

EnsembliENST00000283713; ENSP00000283713; ENSG00000136059. [O15195-1]
ENST00000383759; ENSP00000373266; ENSG00000136059. [O15195-1]
GeneIDi50853.
KEGGihsa:50853.
UCSCiuc003chj.3. human. [O15195-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC105752 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64506.1 .
BC000243 mRNA. Translation: AAH00243.1 . Different initiation.
BC004300 mRNA. Translation: AAH04300.1 . Different initiation.
D88154 mRNA. Translation: BAA21668.1 .
CCDSi CCDS2670.2. [O15195-1 ]
PIRi JC5708.
RefSeqi NP_056957.3. NM_015873.3. [O15195-1 ]
XP_005265248.1. XM_005265191.1. [O15195-1 ]
XP_005265249.1. XM_005265192.2. [O15195-1 ]
XP_006713246.1. XM_006713183.1. [O15195-1 ]
XP_006713247.1. XM_006713184.1. [O15195-1 ]
XP_006713248.1. XM_006713185.1.
UniGenei Hs.103665.

3D structure databases

ProteinModelPortali O15195.
SMRi O15195. Positions 9-714, 801-856.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000283713.

PTM databases

PhosphoSitei O15195.

Proteomic databases

MaxQBi O15195.
PaxDbi O15195.
PRIDEi O15195.

Protocols and materials databases

DNASUi 50853.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000283713 ; ENSP00000283713 ; ENSG00000136059 . [O15195-1 ]
ENST00000383759 ; ENSP00000373266 ; ENSG00000136059 . [O15195-1 ]
GeneIDi 50853.
KEGGi hsa:50853.
UCSCi uc003chj.3. human. [O15195-1 ]

Organism-specific databases

CTDi 50853.
GeneCardsi GC03P038029.
H-InvDB HIX0200527.
HGNCi HGNC:30906. VILL.
HPAi HPA035675.
HPA035676.
neXtProti NX_O15195.
PharmGKBi PA134911684.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG304849.
GeneTreei ENSGT00760000119111.
HOGENOMi HOG000233630.
HOVERGENi HBG004183.
InParanoidi O15195.
OMAi PERAYGN.
OrthoDBi EOG7288RJ.
PhylomeDBi O15195.
TreeFami TF313468.

Miscellaneous databases

ChiTaRSi VILL. human.
GenomeRNAii 50853.
NextBioi 53327.
PROi O15195.

Gene expression databases

Bgeei O15195.
CleanExi HS_VILL.
ExpressionAtlasi O15195. baseline and differential.
Genevestigatori O15195.

Family and domain databases

Gene3Di 1.10.950.10. 1 hit.
3.40.20.10. 6 hits.
InterProi IPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR015626. Villin-like.
IPR007122. Villin/Gelsolin.
IPR003128. Villin_headpiece.
[Graphical view ]
PANTHERi PTHR11977. PTHR11977. 1 hit.
PTHR11977:SF30. PTHR11977:SF30. 1 hit.
Pfami PF00626. Gelsolin. 6 hits.
PF02209. VHP. 1 hit.
[Graphical view ]
PRINTSi PR00597. GELSOLIN.
SMARTi SM00262. GEL. 6 hits.
SM00153. VHP. 1 hit.
[Graphical view ]
SUPFAMi SSF47050. SSF47050. 1 hit.
PROSITEi PS51089. HP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-856 (ISOFORM 1).
    Tissue: Eye and Pancreas.
  4. "Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line."
    Ishikawa S., Kai M., Tamari M., Takei Y., Takeuchi K., Bandou H., Yamane Y., Ogawa M., Nakamura Y.
    DNA Res. 4:35-43(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 171-856 (ISOFORM 1).
    Tissue: Fetal brain, Lung and Pancreas.

Entry informationi

Entry nameiVILL_HUMAN
AccessioniPrimary (citable) accession number: O15195
Secondary accession number(s): A8MZP1, Q9BT80, Q9BWH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 15, 2005
Last modified: October 29, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3