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O15195 (VILL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Villin-like protein
Gene names
Name:VILL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length856 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Possible tumor suppressor.

Tissue specificity

Ubiquitously expressed in 16 tissues examined.

Sequence similarities

Belongs to the villin/gelsolin family.

Contains 6 gelsolin-like repeats.

Contains 1 HP (headpiece) domain.

Sequence caution

The sequence AAH00243.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH04300.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   LigandActin-binding
Calcium
   Molecular functionActin capping
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin filament capping

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton organization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentactin cytoskeleton

Traceable author statement Ref.4. Source: ProtInc

   Molecular_functionstructural constituent of cytoskeleton

Traceable author statement Ref.4. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O15195-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O15195-2)

The sequence of this isoform differs from the canonical sequence as follows:
     262-275: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 856856Villin-like protein
PRO_0000218738

Regions

Repeat22 – 7453Gelsolin-like 1
Repeat146 – 18641Gelsolin-like 2
Repeat263 – 30745Gelsolin-like 3
Repeat401 – 45050Gelsolin-like 4
Repeat521 – 56141Gelsolin-like 5
Repeat624 – 66542Gelsolin-like 6
Domain790 – 85667HP

Natural variations

Alternative sequence262 – 27514Missing in isoform 2.
VSP_006729
Natural variant6101F → L.
Corresponds to variant rs1892814 [ dbSNP | Ensembl ].
VAR_052938
Natural variant7401L → F.
Corresponds to variant rs9816693 [ dbSNP | Ensembl ].
VAR_052939

Experimental info

Sequence conflict2291R → C in BAA21668. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 15, 2005. Version 3.
Checksum: A8B7EDEFDF11CEE1

FASTA85695,907
        10         20         30         40         50         60 
MDISKGLPGM QGGLHIWISE NRKMVPVPEG AYGNFFEEHC YVILHVPQSP KATQGASSDL 

        70         80         90        100        110        120 
HYWVGKQAGA EAQGAAEAFQ QRLQDELGGQ TVLHREAQGH ESDCFCSYFR PGIIYRKGGL 

       130        140        150        160        170        180 
ASDLKHVETN LFNIQRLLHI KGRKHVSATE VELSWNSFNK GDIFLLDLGK MMIQWNGPKT 

       190        200        210        220        230        240 
SISEKARGLA LTYSLRDRER GGGRAQIGVV DDEAKAPDLM QIMEAVLGRR VGSLRAATPS 

       250        260        270        280        290        300 
KDINQLQKAN VRLYHVYEKG KDLVVLELAT PPLTQDLLQE EDFYILDQGG FKIYVWQGRM 

       310        320        330        340        350        360 
SSLQERKAAF SRAVGFIQAK GYPTYTNVEV VNDGAESAAF KQLFRTWSEK RRRNQKLGGR 

       370        380        390        400        410        420 
DKSIHVKLDV GKLHTQPKLA AQLRMVDDGS GKVEVWCIQD LHRQPVDPKR HGQLCAGNCY 

       430        440        450        460        470        480 
LVLYTYQRLG RVQYILYLWQ GHQATADEIE ALNSNAEELD VMYGGVLVQE HVTMGSEPPH 

       490        500        510        520        530        540 
FLAIFQGQLV IFQERAGHHG KGQSASTTRL FQVQGTDSHN TRTMEVPARA SSLNSSDIFL 

       550        560        570        580        590        600 
LVTASVCYLW FGKGCNGDQR EMARVVVTVI SRKNEETVLE GQEPPHFWEA LGGRAPYPSN 

       610        620        630        640        650        660 
KRLPEEVPSF QPRLFECSSH MGCLVLAEVG FFSQEDLDKY DIMLLDTWQE IFLWLGEAAS 

       670        680        690        700        710        720 
EWKEAVAWGQ EYLKTHPAGR SPATPIVLVK QGHEPPTFIG WFFTWDPYKW TSHPSHKEVV 

       730        740        750        760        770        780 
DGSPAAASTI SEITAEVNNL RLSRWPGNGR AGAVALQALK GSQDSSENDL VRSPKSAGSR 

       790        800        810        820        830        840 
TSSSVSSTSA TINGGLRREQ LMHQAVEDLP EGVDPARREF YLSDSDFQDI FGKSKEEFYS 

       850 
MATWRQRQEK KQLGFF 

« Hide

Isoform 2 [UniParc].

Checksum: 2642A8BB552C2788
Show »

FASTA84294,417

References

« Hide 'large scale' references
[1]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-856 (ISOFORM 1).
Tissue: Eye and Pancreas.
[4]"Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line."
Ishikawa S., Kai M., Tamari M., Takei Y., Takeuchi K., Bandou H., Yamane Y., Ogawa M., Nakamura Y.
DNA Res. 4:35-43(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 171-856 (ISOFORM 1).
Tissue: Fetal brain, Lung and Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC105752 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64506.1.
BC000243 mRNA. Translation: AAH00243.1. Different initiation.
BC004300 mRNA. Translation: AAH04300.1. Different initiation.
D88154 mRNA. Translation: BAA21668.1.
CCDSCCDS2670.2. [O15195-1]
PIRJC5708.
RefSeqNP_056957.3. NM_015873.3. [O15195-1]
XP_005265248.1. XM_005265191.1. [O15195-1]
XP_005265249.1. XM_005265192.2. [O15195-1]
XP_006713246.1. XM_006713183.1. [O15195-1]
XP_006713247.1. XM_006713184.1. [O15195-1]
XP_006713248.1. XM_006713185.1.
UniGeneHs.103665.

3D structure databases

ProteinModelPortalO15195.
SMRO15195. Positions 9-714, 801-856.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000283713.

PTM databases

PhosphoSiteO15195.

Proteomic databases

MaxQBO15195.
PaxDbO15195.
PRIDEO15195.

Protocols and materials databases

DNASU50853.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000283713; ENSP00000283713; ENSG00000136059. [O15195-1]
ENST00000383759; ENSP00000373266; ENSG00000136059. [O15195-1]
GeneID50853.
KEGGhsa:50853.
UCSCuc003chj.3. human. [O15195-1]

Organism-specific databases

CTD50853.
GeneCardsGC03P038029.
H-InvDBHIX0200527.
HGNCHGNC:30906. VILL.
HPAHPA035675.
HPA035676.
neXtProtNX_O15195.
PharmGKBPA134911684.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG304849.
HOGENOMHOG000233630.
HOVERGENHBG004183.
InParanoidO15195.
OMAPERAYGN.
OrthoDBEOG7288RJ.
PhylomeDBO15195.
TreeFamTF313468.

Gene expression databases

ArrayExpressO15195.
BgeeO15195.
CleanExHS_VILL.
GenevestigatorO15195.

Family and domain databases

Gene3D1.10.950.10. 1 hit.
3.40.20.10. 6 hits.
InterProIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR015626. Villin-like.
IPR007122. Villin/Gelsolin.
IPR003128. Villin_headpiece.
[Graphical view]
PANTHERPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF30. PTHR11977:SF30. 1 hit.
PfamPF00626. Gelsolin. 6 hits.
PF02209. VHP. 1 hit.
[Graphical view]
PRINTSPR00597. GELSOLIN.
SMARTSM00262. GEL. 6 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMSSF47050. SSF47050. 1 hit.
PROSITEPS51089. HP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSVILL. human.
GenomeRNAi50853.
NextBio53327.
PROO15195.

Entry information

Entry nameVILL_HUMAN
AccessionPrimary (citable) accession number: O15195
Secondary accession number(s): A8MZP1, Q9BT80, Q9BWH7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 15, 2005
Last modified: July 9, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM