O15195 (VILL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Villin-like protein

Gene names

Name:

VILL

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	856 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Possible tumor suppressor.
Tissue specificity	Ubiquitously expressed in 16 tissues examined.
Sequence similarities	Belongs to the villin/gelsolin family. Contains 6 gelsolin-like repeats. Contains 1 HP (headpiece) domain.
Sequence caution	The sequence AAH00243.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH04300.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	Actin-binding Calcium
Molecular function	Actin capping
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	actin filament capping Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular component	actin cytoskeleton Traceable author statement. Source: ProtInc
Molecular function	actin binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of cytoskeleton Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O15195-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O15195-2)

The sequence of this isoform differs from the canonical sequence as follows:
     262-275: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 856	856	Villin-like protein		PRO_0000218738
Regions
	Repeat	22 – 74	53	Gelsolin-like 1
	Repeat	146 – 186	41	Gelsolin-like 2
	Repeat	263 – 307	45	Gelsolin-like 3
	Repeat	401 – 450	50	Gelsolin-like 4
	Repeat	521 – 561	41	Gelsolin-like 5
	Repeat	624 – 665	42	Gelsolin-like 6
	Domain	790 – 856	67	HP
Natural variations
	Alternative sequence	262 – 275	14	Missing in isoform 2.		VSP_006729
	Natural variant	610	1	F → L. Corresponds to variant rs1892814 [ dbSNP | Ensembl ].		VAR_052938
	Natural variant	740	1	L → F. Corresponds to variant rs9816693 [ dbSNP | Ensembl ].		VAR_052939
Experimental info
	Sequence conflict	229	1	R → C in BAA21668. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 15, 2005. Version 3. Checksum: A8B7EDEFDF11CEE1	FASTA	856	95,907
	10 20 30 40 50 60 MDISKGLPGM QGGLHIWISE NRKMVPVPEG AYGNFFEEHC YVILHVPQSP KATQGASSDL 70 80 90 100 110 120 HYWVGKQAGA EAQGAAEAFQ QRLQDELGGQ TVLHREAQGH ESDCFCSYFR PGIIYRKGGL 130 140 150 160 170 180 ASDLKHVETN LFNIQRLLHI KGRKHVSATE VELSWNSFNK GDIFLLDLGK MMIQWNGPKT 190 200 210 220 230 240 SISEKARGLA LTYSLRDRER GGGRAQIGVV DDEAKAPDLM QIMEAVLGRR VGSLRAATPS 250 260 270 280 290 300 KDINQLQKAN VRLYHVYEKG KDLVVLELAT PPLTQDLLQE EDFYILDQGG FKIYVWQGRM 310 320 330 340 350 360 SSLQERKAAF SRAVGFIQAK GYPTYTNVEV VNDGAESAAF KQLFRTWSEK RRRNQKLGGR 370 380 390 400 410 420 DKSIHVKLDV GKLHTQPKLA AQLRMVDDGS GKVEVWCIQD LHRQPVDPKR HGQLCAGNCY 430 440 450 460 470 480 LVLYTYQRLG RVQYILYLWQ GHQATADEIE ALNSNAEELD VMYGGVLVQE HVTMGSEPPH 490 500 510 520 530 540 FLAIFQGQLV IFQERAGHHG KGQSASTTRL FQVQGTDSHN TRTMEVPARA SSLNSSDIFL 550 560 570 580 590 600 LVTASVCYLW FGKGCNGDQR EMARVVVTVI SRKNEETVLE GQEPPHFWEA LGGRAPYPSN 610 620 630 640 650 660 KRLPEEVPSF QPRLFECSSH MGCLVLAEVG FFSQEDLDKY DIMLLDTWQE IFLWLGEAAS 670 680 690 700 710 720 EWKEAVAWGQ EYLKTHPAGR SPATPIVLVK QGHEPPTFIG WFFTWDPYKW TSHPSHKEVV 730 740 750 760 770 780 DGSPAAASTI SEITAEVNNL RLSRWPGNGR AGAVALQALK GSQDSSENDL VRSPKSAGSR 790 800 810 820 830 840 TSSSVSSTSA TINGGLRREQ LMHQAVEDLP EGVDPARREF YLSDSDFQDI FGKSKEEFYS 850 MATWRQRQEK KQLGFF
	Isoform 2 [UniParc]. Checksum: 2642A8BB552C2788	FASTA	842	94,417
	10 20 30 40 50 60 MDISKGLPGM QGGLHIWISE NRKMVPVPEG AYGNFFEEHC YVILHVPQSP KATQGASSDL 70 80 90 100 110 120 HYWVGKQAGA EAQGAAEAFQ QRLQDELGGQ TVLHREAQGH ESDCFCSYFR PGIIYRKGGL 130 140 150 160 170 180 ASDLKHVETN LFNIQRLLHI KGRKHVSATE VELSWNSFNK GDIFLLDLGK MMIQWNGPKT 190 200 210 220 230 240 SISEKARGLA LTYSLRDRER GGGRAQIGVV DDEAKAPDLM QIMEAVLGRR VGSLRAATPS 250 260 270 280 290 300 KDINQLQKAN VRLYHVYEKG KDLLQEEDFY ILDQGGFKIY VWQGRMSSLQ ERKAAFSRAV 310 320 330 340 350 360 GFIQAKGYPT YTNVEVVNDG AESAAFKQLF RTWSEKRRRN QKLGGRDKSI HVKLDVGKLH 370 380 390 400 410 420 TQPKLAAQLR MVDDGSGKVE VWCIQDLHRQ PVDPKRHGQL CAGNCYLVLY TYQRLGRVQY 430 440 450 460 470 480 ILYLWQGHQA TADEIEALNS NAEELDVMYG GVLVQEHVTM GSEPPHFLAI FQGQLVIFQE 490 500 510 520 530 540 RAGHHGKGQS ASTTRLFQVQ GTDSHNTRTM EVPARASSLN SSDIFLLVTA SVCYLWFGKG 550 560 570 580 590 600 CNGDQREMAR VVVTVISRKN EETVLEGQEP PHFWEALGGR APYPSNKRLP EEVPSFQPRL 610 620 630 640 650 660 FECSSHMGCL VLAEVGFFSQ EDLDKYDIML LDTWQEIFLW LGEAASEWKE AVAWGQEYLK 670 680 690 700 710 720 THPAGRSPAT PIVLVKQGHE PPTFIGWFFT WDPYKWTSHP SHKEVVDGSP AAASTISEIT 730 740 750 760 770 780 AEVNNLRLSR WPGNGRAGAV ALQALKGSQD SSENDLVRSP KSAGSRTSSS VSSTSATING 790 800 810 820 830 840 GLRREQLMHQ AVEDLPEGVD PARREFYLSD SDFQDIFGKS KEEFYSMATW RQRQEKKQLG FF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-856 (ISOFORM 1). Tissue: Eye and Pancreas.
[4]	"Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line." Ishikawa S., Kai M., Tamari M., Takei Y., Takeuchi K., Bandou H., Yamane Y., Ogawa M., Nakamura Y. DNA Res. 4:35-43(1997) [PubMed: 9179494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 171-856 (ISOFORM 1). Tissue: Fetal brain, Lung and Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC105752 Genomic DNA. No translation available. CH471055 Genomic DNA. Translation: EAW64506.1. BC000243 mRNA. Translation: AAH00243.1. Different initiation. BC004300 mRNA. Translation: AAH04300.1. Different initiation. D88154 mRNA. Translation: BAA21668.1.
IPI	IPI00215851. IPI00289639.
PIR	JC5708.
RefSeq	NP_056957.3. NM_015873.3.
UniGene	Hs.103665.
3D structure databases
ProteinModelPortal	O15195.
SMR	O15195. Positions 1-724, 794-856.
ModBase	Search...
Protein-protein interaction databases
STRING	O15195.
Proteomic databases
PRIDE	O15195.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000283713; ENSP00000283713; ENSG00000136059. ENST00000383759; ENSP00000373266; ENSG00000136059.
GeneID	50853.
KEGG	hsa:50853.
UCSC	uc003chj.1. human.
Organism-specific databases
CTD	50853.
GeneCards	GC03P038029.
H-InvDB	HIX0200527.
HGNC	HGNC:30906. VILL.
HPA	HPA035675.
neXtProt	NX_O15195.
PharmGKB	PA134911684.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10378.
GeneTree	ENSGT00550000074169.
HOGENOM	HBG357198.
HOVERGEN	HBG004183.
InParanoid	O15195.
OMA	PERAYGN.
OrthoDB	EOG4NCMC5.
PhylomeDB	O15195.
Gene expression databases
ArrayExpress	O15195.
Bgee	O15195.
CleanEx	HS_VILL.
Genevestigator	O15195.
GermOnline	ENSG00000136059. Homo sapiens.
Family and domain databases
InterPro	IPR007122. Gelsolin. IPR007123. Gelsolin_dom. IPR015626. Villin-related. IPR003128. Villin_headpiece. [Graphical view]
Gene3D	G3DSA:1.10.950.10. VHP. 1 hit.
PANTHER	PTHR11977. Gelsolin. 1 hit. PTHR11977:SF12. Villin_related. 1 hit.
Pfam	PF00626. Gelsolin. 6 hits. PF02209. VHP. 1 hit. [Graphical view]
PRINTS	PR00597. GELSOLIN.
SMART	SM00262. GEL. 6 hits. SM00153. VHP. 1 hit. [Graphical view]
SUPFAM	SSF47050. VHP. 1 hit.
PROSITE	PS51089. HP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	53327.

Entry information

Entry name

VILL_HUMAN

Accession

Primary (citable) accession number: O15195
Secondary accession number(s): A8MZP1, Q9BT80, Q9BWH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 99 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.