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Reviewed, UniProtKB/Swiss-Prot O15194 (CTDSL_HUMAN)

Last modified June 16, 2009. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    CTD small phosphatase-like protein
      Short name=CTDSP-like
    EC=3.1.3.-
Alternative name(s):
    Small C-terminal domain phosphatase 3
      Short name=Small CTD phosphatase 3
      Short name=SCP3
    Nuclear LIM interactor-interacting factor 1
      Short name=NLI-interacting factor 1
    NIF-like protein
    RBSP3
    Protein YA22
      Short name=hYA22
Gene names
Name: CTDSPL
Synonyms: C3orf8, NIF1, NIFL, SCP3, YA22
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May function as a phosphatase involved in the regulation of cell growth and differentiation.

Subunit structure

Interacts with LDB1 By similarity.

Subcellular location

Nucleus Potential.

Tissue specificity

Ubiquitously expressed.

Sequence similarities

Contains 1 FCP1 homology domain.

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Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionHydrolase
Protein phosphatase
   Technical term3D-structure
Gene Ontology (GO)
   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionphosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O15194-1)

Also known as: HYA22B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O15194-2)

Also known as: HYA22A;

The sequence of this isoform differs from the canonical sequence as follows:
     79-89: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276CTD small phosphatase-like protein
PRO_0000212569

Regions

Domain102 – 260159FCP1 homology

Natural variations

Alternative sequence79 – 8911Missing in isoform 2.
VSP_011541
Natural variant1211S → P Ref.3
VAR_019683
Natural variant1271N → S Ref.3
VAR_019684
Natural variant1321V → G Ref.3
VAR_019685

Secondary structure

1 ........................................ 276
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (HYA22B) [UniParc].

Last modified August 31, 2004. Version 2.
Checksum: 5C7B32A1127B0F59

FASTA27631,129
        10         20         30         40         50         60 
MDGPAIITQV TNPKEDEGRL PGAGEKASQC NVSLKKQRSR SILSSFFCCF RDYNVEAPPP 

        70         80         90        100        110        120 
SSPSVLPPLV EENGGLQKGD QRQVIPIPSP PAKYLLPEVT VLDYGKKCVV IDLDETLVHS 

       130        140        150        160        170        180 
SFKPISNADF IVPVEIDGTI HQVYVLKRPH VDEFLQRMGQ LFECVLFTAS LAKYADPVAD 

       190        200        210        220        230        240 
LLDRWGVFRA RLFRESCVFH RGNYVKDLSR LGRELSKVII VDNSPASYIF HPENAVPVQS 

       250        260        270 
WFDDMTDTEL LDLIPFFEGL SREDDVYSML HRLCNR

« Hide

Isoform 2 (HYA22A).

Checksum: D19C4461386C1C2F
Show »

FASTA26529,937

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References

« Hide 'large scale' references
[1]"Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line."
Ishikawa S., Kai M., Tamari M., Takei Y., Takeuchi K., Bandou H., Yamane Y., Ogawa M., Nakamura Y.
DNA Res. 4:35-43(1997) [PubMed: 9179494] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Fetal brain, Lung and Pancreas.
[2]"A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5."
Yeo M., Lin P.S., Dahmus M.E., Gill G.N.
J. Biol. Chem. 278:26078-26085(2003) [PubMed: 12721286] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies."
Kashuba V.I., Li J., Wang F., Senchenko V.N., Protopopov A., Malyukova A., Kutsenko A.S., Kadyrova E., Zabarovska V.I., Muravenko O.V., Zelenin A.V., Kisselev L.L., Kuzmin I., Minna J.D., Winberg G., Ernberg I., Braga E., Lerman M.I., Klein G., Zabarovsky E.R.
Proc. Natl. Acad. Sci. U.S.A. 101:4906-4911(2004) [PubMed: 15051889] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS PRO-121; SER-127 AND GLY-132.
Tissue: Lung.
[4]"NovelFam3000 -- uncharacterized human protein domains conserved across model organisms."
Kemmer D., Podowski R.M., Arenillas D., Lim J., Hodges E., Roth P., Sonnhammer E.L.L., Hoeoeg C., Wasserman W.W.
BMC Genomics 7:48-48(2006) [PubMed: 16533400] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+Additional computationally mapped references.

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Cross-references

Sequence databases

D88153 mRNA. Translation: BAA21667.1. Different initiation.
AY279532 mRNA. Translation: AAP34400.1.
AJ575644 mRNA. Translation: CAE11804.1.
AJ575645 mRNA. Translation: CAE11805.1.
AY364238 mRNA. Translation: AAQ76797.1.
IPIIPI00024826.
IPI00454757.
PIRJC5707.
RefSeqNP_001008393.1.
NP_005799.2.
UniGeneHs.475963

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2HHLX-ray2.10A/B/C/D82-265[»]
ModBaseSearch...

Genome annotation databases

EnsemblENSG00000144677. Homo sapiens. [Contig view]
GeneID10217.
KEGGhsa:10217.

Organism-specific databases

GeneCardsGC03P037878.
H-InvDBHIX0012197.
HIX0030756.
HGNCHGNC:16890. CTDSPL.
MIM608592. gene.
PharmGKBPA128394571.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO15194.
HOVERGENO15194.
OMAO15194. QRSRSIF.

Enzyme and pathway databases

Pathway_Interaction_DBbmppathway. BMP receptor signaling.
smad2_3pathway. Regulation of cytoplasmic and nuclear SMAD2/3 signaling.

Gene expression databases

ArrayExpressO15194.
BgeeO15194.
CleanExHS_CTDSPL.
GermOnlineENSG00000144677. Homo sapiens.

Family and domain databases

InterProIPR011948. Dullard.
IPR004274. NIF.
[Graphical view]
PfamPF03031. NIF. 1 hit.
[Graphical view]
SMARTSM00577. CPDc. 1 hit.
[Graphical view]
TIGRFAMsTIGR02251. HIF-SF_euk. 1 hit.
PROSITEPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio38686.
SOURCESearch...

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Entry information

Entry nameCTDSL_HUMAN
AccessionPrimary (citable) accession number: O15194
Secondary accession number(s): Q3ZTU0, Q70KI4, Q7Z5Q2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: August 31, 2004
Last modified: June 16, 2009
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents