Reviewed,
UniProtKB/Swiss-Prot O15194 (CTDSL_HUMAN)
Last modified
June 16, 2009.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: CTD small phosphatase-like protein Short name=CTDSP-like EC=3.1.3.- Alternative name(s): Small C-terminal domain phosphatase 3 Short name=Small CTD phosphatase 3 Short name=SCP3 Nuclear LIM interactor-interacting factor 1 Short name=NLI-interacting factor 1 NIF-like protein RBSP3 Protein YA22 Short name=hYA22 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 276 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May function as a phosphatase involved in the regulation of cell growth and differentiation. |
| Subunit structure | Interacts with LDB1 By similarity. |
| Subcellular location | Nucleus Potential. |
| Tissue specificity | Ubiquitously expressed. |
| Sequence similarities | Contains 1 FCP1 homology domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Nucleus |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Molecular function | Hydrolase Protein phosphatase |
| Technical term | 3D-structure |
| Gene Ontology (GO) | |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: O15194-1) Also known as: HYA22B; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: O15194-2) Also known as: HYA22A; The sequence of this isoform differs from the canonical sequence as follows: 79-89: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 276 | 276 | CTD small phosphatase-like protein | PRO_0000212569 | ||||||||||||||||||||||||||||||||||||||||||||
Regions | ||||||||||||||||||||||||||||||||||||||||||||||||
| Domain | 102 – 260 | 159 | FCP1 homology | |||||||||||||||||||||||||||||||||||||||||||||
Natural variations | ||||||||||||||||||||||||||||||||||||||||||||||||
| Alternative sequence | 79 – 89 | 11 | Missing in isoform 2. | VSP_011541 | ||||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 121 | 1 | S → P Ref.3 | VAR_019683 | ||||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 127 | 1 | N → S Ref.3 | VAR_019684 | ||||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 132 | 1 | V → G Ref.3 | VAR_019685 | ||||||||||||||||||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 93 – 96 | 4 | ||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 101 – 103 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 108 – 111 | 4 | ||||||||||||||||||||||||||||||||||||||||||||||
| Turn | 115 – 117 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 118 – 123 | 6 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 129 – 136 | 8 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 139 – 147 | 9 | ||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 151 – 161 | 11 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 162 – 167 | 6 | ||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 172 – 182 | 11 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 188 – 192 | 5 | ||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 194 – 196 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 198 – 200 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 203 – 205 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 208 – 210 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 211 – 213 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 215 – 217 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 218 – 223 | 6 | ||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 225 – 228 | 4 | ||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 232 – 234 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 235 – 237 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 249 – 261 | 13 | ||||||||||||||||||||||||||||||||||||||||||||||
Sequences
| ||||||||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line." Ishikawa S., Kai M., Tamari M., Takei Y., Takeuchi K., Bandou H., Yamane Y., Ogawa M., Nakamura Y. DNA Res. 4:35-43(1997) [PubMed: 9179494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Fetal brain, Lung and Pancreas. |
| [2] | "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5." Yeo M., Lin P.S., Dahmus M.E., Gill G.N. J. Biol. Chem. 278:26078-26085(2003) [PubMed: 12721286] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). |
| [3] | "RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies." Kashuba V.I., Li J., Wang F., Senchenko V.N., Protopopov A., Malyukova A., Kutsenko A.S., Kadyrova E., Zabarovska V.I., Muravenko O.V., Zelenin A.V., Kisselev L.L., Kuzmin I., Minna J.D., Winberg G., Ernberg I., Braga E., Lerman M.I., Klein G., Zabarovsky E.R. Proc. Natl. Acad. Sci. U.S.A. 101:4906-4911(2004) [PubMed: 15051889] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS PRO-121; SER-127 AND GLY-132. Tissue: Lung. |
| [4] | "NovelFam3000 -- uncharacterized human protein domains conserved across model organisms." Kemmer D., Podowski R.M., Arenillas D., Lim J., Hodges E., Roth P., Sonnhammer E.L.L., Hoeoeg C., Wasserman W.W. BMC Genomics 7:48-48(2006) [PubMed: 16533400] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D88153 mRNA. Translation: BAA21667.1. Different initiation. AY279532 mRNA. Translation: AAP34400.1. AJ575644 mRNA. Translation: CAE11804.1. AJ575645 mRNA. Translation: CAE11805.1. AY364238 mRNA. Translation: AAQ76797.1. | |||||||||||||
| IPI | IPI00024826. IPI00454757. | ||||||||||||
| PIR | JC5707. | ||||||||||||
| RefSeq | NP_001008393.1. NP_005799.2. | ||||||||||||
| UniGene | Hs.475963 | ||||||||||||
3D structure databases | |||||||||||||
| |||||||||||||
| ModBase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000144677. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 10217. | ||||||||||||
| KEGG | hsa:10217. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneCards | GC03P037878. | ||||||||||||
| H-InvDB | HIX0012197. HIX0030756. | ||||||||||||
| HGNC | HGNC:16890. CTDSPL. | ||||||||||||
| MIM | 608592. gene. | ||||||||||||
| PharmGKB | PA128394571. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | O15194. | ||||||||||||
| HOVERGEN | O15194. | ||||||||||||
| OMA | O15194. QRSRSIF. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| Pathway_Interaction_DB | bmppathway. BMP receptor signaling. smad2_3pathway. Regulation of cytoplasmic and nuclear SMAD2/3 signaling. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | O15194. | ||||||||||||
| Bgee | O15194. | ||||||||||||
| CleanEx | HS_CTDSPL. | ||||||||||||
| GermOnline | ENSG00000144677. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR011948. Dullard. IPR004274. NIF. [Graphical view] | ||||||||||||
| Pfam | PF03031. NIF. 1 hit. [Graphical view] | ||||||||||||
| SMART | SM00577. CPDc. 1 hit. [Graphical view] | ||||||||||||
| TIGRFAMs | TIGR02251. HIF-SF_euk. 1 hit. | ||||||||||||
| PROSITE | PS50969. FCP1. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 38686. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | CTDSL_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O15194 Secondary accession number(s): Q3ZTU0, Q70KI4, Q7Z5Q2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


