O15182 (CETN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Centrin-3

Gene names

Name:	CETN3
Synonyms:	CEN3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a fundamental role in microtubule-organizing center structure and function.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytoskeleton › centrosome. Note: Centrosome of interphase and mitotic cells.
Sequence similarities	Belongs to the centrin family. Contains 4 EF-hand domains.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Polymorphism
Domain	Repeat
Ligand	Calcium Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW centrosome cycle Traceable author statement Ref.1. Source: ProtInc mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	centriole Traceable author statement Ref.1. Source: ProtInc intermediate filament cytoskeleton Inferred from direct assay. Source: HPA microtubule basal body Inferred from electronic annotation. Source: Compara photoreceptor connecting cilium Inferred from electronic annotation. Source: Compara
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Centrin-3		PRO_0000073563
Regions
	Domain	25 – 60	36	EF-hand 1
	Domain	61 – 96	36	EF-hand 2
	Domain	98 – 133	36	EF-hand 3
	Domain	134 – 167	34	EF-hand 4
	Calcium binding	38 – 49	12	1 Potential
	Calcium binding	147 – 158	12	2 Probable
Natural variations
	Natural variant	10	1	V → L. Ref.1 Corresponds to variant rs4873 [ dbSNP | Ensembl ].		VAR_030846

Sequences

	Sequence		Length	Mass (Da)
	O15182 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: EF67724B2D6C2680	FASTA	167	19,550
	10 20 30 40 50 60 MSLALRSELV VDKTKRKKRR ELSEEQKQEI KDAFELFDTD KDEAIDYHEL KVAMRALGFD 70 80 90 100 110 120 VKKADVLKIL KDYDREATGK ITFEDFNEVV TDWILERDPH EEILKAFKLF DDDDSGKISL 130 140 150 160 RNLRRVAREL GENMSDEELR AMIEEFDKDG DGEINQEEFI AIMTGDI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene." Middendorp S., Paoletti A., Schiebel E., Bornens M. Proc. Natl. Acad. Sci. U.S.A. 94:9141-9146(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-10.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y12473 mRNA. Translation: CAA73077.1. BT006688 mRNA. Translation: AAP35334.1. AC093510 Genomic DNA. No translation available. BC005383 mRNA. Translation: AAH05383.1. BC093793 mRNA. Translation: AAH93793.1. BC112040 mRNA. Translation: AAI12041.1.
IPI	IPI00005210.
RefSeq	NP_004356.2. NM_004365.2.
UniGene	Hs.591767.
3D structure databases
ProteinModelPortal	O15182.
ModBase	Search...
Protein-protein interaction databases
IntAct	O15182. 9 interactions.
MINT	MINT-1368980.
STRING	9606.ENSP00000283122.
PTM databases
PhosphoSite	O15182.
Proteomic databases
PaxDb	O15182.
PRIDE	O15182.
Protocols and materials databases
DNASU	1070.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000283122; ENSP00000283122; ENSG00000153140.
GeneID	1070.
KEGG	hsa:1070.
UCSC	uc003kjo.3. human.
Organism-specific databases
CTD	1070.
GeneCards	GC05M089688.
HGNC	HGNC:1868. CETN3.
HPA	HPA035608.
MIM	602907. gene.
neXtProt	NX_O15182.
PharmGKB	PA26421.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5126.
HOGENOM	HOG000233018.
HOVERGEN	HBG012180.
InParanoid	O15182.
KO	K16466.
OrthoDB	EOG4W9J53.
PhylomeDB	O15182.
Gene expression databases
ArrayExpress	O15182.
Bgee	O15182.
CleanEx	HS_CETN3.
Genevestigator	O15182.
GermOnline	ENSG00000153140. Homo sapiens.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. [Graphical view]
Pfam	PF13499. EF_hand_5. 2 hits. [Graphical view]
SMART	SM00054. EFh. 4 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1070.
NextBio	4468.
SOURCE	Search...

Entry information

Entry name

CETN3_HUMAN

Accession

Primary (citable) accession number: O15182
Secondary accession number(s): Q53YD2, Q9BS23

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.