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Protein

Centrin-3

Gene

CETN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a fundamental role in microtubule-organizing center structure and function.
Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:22307388).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi38 – 49121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi147 – 158122CuratedAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. centrosome cycle Source: ProtInc
  3. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Centrin-3
Gene namesi
Name:CETN3
Synonyms:CEN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:1868. CETN3.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Nucleusnucleolus 1 Publication
Note: Centrosome of interphase and mitotic cells.

GO - Cellular componenti

  1. centriole Source: ProtInc
  2. centrosome Source: UniProtKB
  3. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26421.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Centrin-3PRO_0000073563Add
BLAST

Proteomic databases

MaxQBiO15182.
PaxDbiO15182.
PRIDEiO15182.

PTM databases

PhosphoSiteiO15182.

Expressioni

Gene expression databases

BgeeiO15182.
CleanExiHS_CETN3.
ExpressionAtlasiO15182. baseline and differential.
GenevestigatoriO15182.

Organism-specific databases

HPAiHPA035608.

Interactioni

Subunit structurei

Monomer (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388).By similarity1 Publication

Protein-protein interaction databases

BioGridi107497. 18 interactions.
IntActiO15182. 10 interactions.
MINTiMINT-1368980.
STRINGi9606.ENSP00000283122.

Structurei

3D structure databases

ProteinModelPortaliO15182.
SMRiO15182. Positions 21-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 6036EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini61 – 9636EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini98 – 13336EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 16734EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the centrin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00670000097718.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiO15182.
KOiK16466.
OrthoDBiEOG7H1JN9.
PhylomeDBiO15182.
TreeFamiTF101141.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O15182-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLALRSELV VDKTKRKKRR ELSEEQKQEI KDAFELFDTD KDEAIDYHEL
60 70 80 90 100
KVAMRALGFD VKKADVLKIL KDYDREATGK ITFEDFNEVV TDWILERDPH
110 120 130 140 150
EEILKAFKLF DDDDSGKISL RNLRRVAREL GENMSDEELR AMIEEFDKDG
160
DGEINQEEFI AIMTGDI
Length:167
Mass (Da):19,550
Last modified:February 20, 2007 - v2
Checksum:iEF67724B2D6C2680
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101V → L.1 Publication
Corresponds to variant rs4873 [ dbSNP | Ensembl ].
VAR_030846

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12473 mRNA. Translation: CAA73077.1.
BT006688 mRNA. Translation: AAP35334.1.
AC093510 Genomic DNA. No translation available.
BC005383 mRNA. Translation: AAH05383.1.
BC093793 mRNA. Translation: AAH93793.1.
BC112040 mRNA. Translation: AAI12041.1.
CCDSiCCDS4066.1.
RefSeqiNP_001284697.1. NM_001297768.1.
NP_004356.2. NM_004365.3.
UniGeneiHs.591767.

Genome annotation databases

EnsembliENST00000283122; ENSP00000283122; ENSG00000153140.
GeneIDi1070.
KEGGihsa:1070.
UCSCiuc003kjo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12473 mRNA. Translation: CAA73077.1.
BT006688 mRNA. Translation: AAP35334.1.
AC093510 Genomic DNA. No translation available.
BC005383 mRNA. Translation: AAH05383.1.
BC093793 mRNA. Translation: AAH93793.1.
BC112040 mRNA. Translation: AAI12041.1.
CCDSiCCDS4066.1.
RefSeqiNP_001284697.1. NM_001297768.1.
NP_004356.2. NM_004365.3.
UniGeneiHs.591767.

3D structure databases

ProteinModelPortaliO15182.
SMRiO15182. Positions 21-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107497. 18 interactions.
IntActiO15182. 10 interactions.
MINTiMINT-1368980.
STRINGi9606.ENSP00000283122.

PTM databases

PhosphoSiteiO15182.

Proteomic databases

MaxQBiO15182.
PaxDbiO15182.
PRIDEiO15182.

Protocols and materials databases

DNASUi1070.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283122; ENSP00000283122; ENSG00000153140.
GeneIDi1070.
KEGGihsa:1070.
UCSCiuc003kjo.3. human.

Organism-specific databases

CTDi1070.
GeneCardsiGC05M089688.
HGNCiHGNC:1868. CETN3.
HPAiHPA035608.
MIMi602907. gene.
neXtProtiNX_O15182.
PharmGKBiPA26421.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00670000097718.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiO15182.
KOiK16466.
OrthoDBiEOG7H1JN9.
PhylomeDBiO15182.
TreeFamiTF101141.

Miscellaneous databases

GeneWikiiCETN3.
GenomeRNAii1070.
NextBioi4468.
PROiO15182.
SOURCEiSearch...

Gene expression databases

BgeeiO15182.
CleanExiHS_CETN3.
ExpressionAtlasiO15182. baseline and differential.
GenevestigatoriO15182.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene."
    Middendorp S., Paoletti A., Schiebel E., Bornens M.
    Proc. Natl. Acad. Sci. U.S.A. 94:9141-9146(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-10.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Testis.
  5. "Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export."
    Jani D., Lutz S., Hurt E., Laskey R.A., Stewart M., Wickramasinghe V.O.
    Nucleic Acids Res. 40:4562-4573(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TREX-2 COMPLEX, FUNCTION.

Entry informationi

Entry nameiCETN3_HUMAN
AccessioniPrimary (citable) accession number: O15182
Secondary accession number(s): Q53YD2, Q9BS23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 20, 2007
Last modified: February 4, 2015
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.