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O15182 (CETN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Centrin-3
Gene names
Name:CETN3
Synonyms:CEN3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a fundamental role in microtubule-organizing center structure and function.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Note: Centrosome of interphase and mitotic cells.

Sequence similarities

Belongs to the centrin family.

Contains 4 EF-hand domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 167167Centrin-3
PRO_0000073563

Regions

Domain25 – 6036EF-hand 1
Domain61 – 9636EF-hand 2
Domain98 – 13336EF-hand 3
Domain134 – 16734EF-hand 4
Calcium binding38 – 49121 Potential
Calcium binding147 – 158122 Probable

Natural variations

Natural variant101V → L. Ref.1
Corresponds to variant rs4873 [ dbSNP | Ensembl ].
VAR_030846

Sequences

Sequence LengthMass (Da)Tools
O15182 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: EF67724B2D6C2680

FASTA16719,550
        10         20         30         40         50         60 
MSLALRSELV VDKTKRKKRR ELSEEQKQEI KDAFELFDTD KDEAIDYHEL KVAMRALGFD 

        70         80         90        100        110        120 
VKKADVLKIL KDYDREATGK ITFEDFNEVV TDWILERDPH EEILKAFKLF DDDDSGKISL 

       130        140        150        160 
RNLRRVAREL GENMSDEELR AMIEEFDKDG DGEINQEEFI AIMTGDI 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene."
Middendorp S., Paoletti A., Schiebel E., Bornens M.
Proc. Natl. Acad. Sci. U.S.A. 94:9141-9146(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-10.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y12473 mRNA. Translation: CAA73077.1.
BT006688 mRNA. Translation: AAP35334.1.
AC093510 Genomic DNA. No translation available.
BC005383 mRNA. Translation: AAH05383.1.
BC093793 mRNA. Translation: AAH93793.1.
BC112040 mRNA. Translation: AAI12041.1.
RefSeqNP_004356.2. NM_004365.2.
UniGeneHs.591767.

3D structure databases

ProteinModelPortalO15182.
SMRO15182. Positions 21-164.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107497. 7 interactions.
IntActO15182. 9 interactions.
MINTMINT-1368980.
STRING9606.ENSP00000283122.

PTM databases

PhosphoSiteO15182.

Proteomic databases

PaxDbO15182.
PRIDEO15182.

Protocols and materials databases

DNASU1070.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000283122; ENSP00000283122; ENSG00000153140.
GeneID1070.
KEGGhsa:1070.
UCSCuc003kjo.3. human.

Organism-specific databases

CTD1070.
GeneCardsGC05M089688.
HGNCHGNC:1868. CETN3.
HPAHPA035608.
MIM602907. gene.
neXtProtNX_O15182.
PharmGKBPA26421.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5126.
HOGENOMHOG000233018.
HOVERGENHBG012180.
InParanoidO15182.
KOK16466.
OrthoDBEOG7H1JN9.
PhylomeDBO15182.
TreeFamTF101141.

Gene expression databases

ArrayExpressO15182.
BgeeO15182.
CleanExHS_CETN3.
GenevestigatorO15182.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTSM00054. EFh. 4 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCETN3.
GenomeRNAi1070.
NextBio4468.
PROO15182.
SOURCESearch...

Entry information

Entry nameCETN3_HUMAN
AccessionPrimary (citable) accession number: O15182
Secondary accession number(s): Q53YD2, Q9BS23
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM