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O15182

- CETN3_HUMAN

UniProt

O15182 - CETN3_HUMAN

Protein

Centrin-3

Gene

CETN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Plays a fundamental role in microtubule-organizing center structure and function.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi38 – 49121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi147 – 158122CuratedAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. centrosome cycle Source: ProtInc
    2. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centrin-3
    Gene namesi
    Name:CETN3
    Synonyms:CEN3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:1868. CETN3.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome
    Note: Centrosome of interphase and mitotic cells.

    GO - Cellular componenti

    1. centriole Source: ProtInc
    2. centrosome Source: UniProtKB
    3. cytoplasm Source: HPA
    4. intermediate filament cytoskeleton Source: HPA
    5. photoreceptor connecting cilium Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26421.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 167167Centrin-3PRO_0000073563Add
    BLAST

    Proteomic databases

    MaxQBiO15182.
    PaxDbiO15182.
    PRIDEiO15182.

    PTM databases

    PhosphoSiteiO15182.

    Expressioni

    Gene expression databases

    ArrayExpressiO15182.
    BgeeiO15182.
    CleanExiHS_CETN3.
    GenevestigatoriO15182.

    Organism-specific databases

    HPAiHPA035608.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    BioGridi107497. 7 interactions.
    IntActiO15182. 9 interactions.
    MINTiMINT-1368980.
    STRINGi9606.ENSP00000283122.

    Structurei

    3D structure databases

    ProteinModelPortaliO15182.
    SMRiO15182. Positions 21-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 6036EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini61 – 9636EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini98 – 13336EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini134 – 16734EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the centrin family.Curated
    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    HOGENOMiHOG000233018.
    HOVERGENiHBG012180.
    InParanoidiO15182.
    KOiK16466.
    OrthoDBiEOG7H1JN9.
    PhylomeDBiO15182.
    TreeFamiTF101141.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13499. EF-hand_7. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 4 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O15182-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLALRSELV VDKTKRKKRR ELSEEQKQEI KDAFELFDTD KDEAIDYHEL    50
    KVAMRALGFD VKKADVLKIL KDYDREATGK ITFEDFNEVV TDWILERDPH 100
    EEILKAFKLF DDDDSGKISL RNLRRVAREL GENMSDEELR AMIEEFDKDG 150
    DGEINQEEFI AIMTGDI 167
    Length:167
    Mass (Da):19,550
    Last modified:February 20, 2007 - v2
    Checksum:iEF67724B2D6C2680
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101V → L.1 Publication
    Corresponds to variant rs4873 [ dbSNP | Ensembl ].
    VAR_030846

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12473 mRNA. Translation: CAA73077.1.
    BT006688 mRNA. Translation: AAP35334.1.
    AC093510 Genomic DNA. No translation available.
    BC005383 mRNA. Translation: AAH05383.1.
    BC093793 mRNA. Translation: AAH93793.1.
    BC112040 mRNA. Translation: AAI12041.1.
    CCDSiCCDS4066.1.
    RefSeqiNP_004356.2. NM_004365.2.
    UniGeneiHs.591767.

    Genome annotation databases

    EnsembliENST00000283122; ENSP00000283122; ENSG00000153140.
    GeneIDi1070.
    KEGGihsa:1070.
    UCSCiuc003kjo.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12473 mRNA. Translation: CAA73077.1 .
    BT006688 mRNA. Translation: AAP35334.1 .
    AC093510 Genomic DNA. No translation available.
    BC005383 mRNA. Translation: AAH05383.1 .
    BC093793 mRNA. Translation: AAH93793.1 .
    BC112040 mRNA. Translation: AAI12041.1 .
    CCDSi CCDS4066.1.
    RefSeqi NP_004356.2. NM_004365.2.
    UniGenei Hs.591767.

    3D structure databases

    ProteinModelPortali O15182.
    SMRi O15182. Positions 21-164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107497. 7 interactions.
    IntActi O15182. 9 interactions.
    MINTi MINT-1368980.
    STRINGi 9606.ENSP00000283122.

    PTM databases

    PhosphoSitei O15182.

    Proteomic databases

    MaxQBi O15182.
    PaxDbi O15182.
    PRIDEi O15182.

    Protocols and materials databases

    DNASUi 1070.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000283122 ; ENSP00000283122 ; ENSG00000153140 .
    GeneIDi 1070.
    KEGGi hsa:1070.
    UCSCi uc003kjo.3. human.

    Organism-specific databases

    CTDi 1070.
    GeneCardsi GC05M089688.
    HGNCi HGNC:1868. CETN3.
    HPAi HPA035608.
    MIMi 602907. gene.
    neXtProti NX_O15182.
    PharmGKBi PA26421.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5126.
    HOGENOMi HOG000233018.
    HOVERGENi HBG012180.
    InParanoidi O15182.
    KOi K16466.
    OrthoDBi EOG7H1JN9.
    PhylomeDBi O15182.
    TreeFami TF101141.

    Miscellaneous databases

    GeneWikii CETN3.
    GenomeRNAii 1070.
    NextBioi 4468.
    PROi O15182.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O15182.
    Bgeei O15182.
    CleanExi HS_CETN3.
    Genevestigatori O15182.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13499. EF-hand_7. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 4 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene."
      Middendorp S., Paoletti A., Schiebel E., Bornens M.
      Proc. Natl. Acad. Sci. U.S.A. 94:9141-9146(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-10.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Testis.

    Entry informationi

    Entry nameiCETN3_HUMAN
    AccessioniPrimary (citable) accession number: O15182
    Secondary accession number(s): Q53YD2, Q9BS23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3